locus-tag	class	description
MAIC_00050	COG1309	transcriptional regulator
MAIC_00220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MAIC_00230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAIC_00250	COG1414	Transcriptional regulator
MAIC_00260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAIC_00270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAIC_00280	COG0187	DNA topoisomerase II activity
MAIC_00290	COG1846	Transcriptional regulator
MAIC_00360	COG0475	glutathione-regulated potassium exporter activity
MAIC_00390	COG2076	Multidrug Resistance protein
MAIC_00510	COG5002	protein histidine kinase activity
MAIC_00510	COG5001	Diguanylate cyclase
MAIC_00510	COG3447	MASE1 domain protein
MAIC_00530	COG0531	amino acid
MAIC_00540	COG3300	MHYT domain
MAIC_00540	COG5001	Diguanylate cyclase
MAIC_00550	COG5002	protein histidine kinase activity
MAIC_00550	COG0784	Response regulator, receiver
MAIC_00560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MAIC_00570	COG2201	protein-glutamate methylesterase activity
MAIC_00580	COG2030	dehydratase
MAIC_00610	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_00620	COG0583	DNA-binding transcription factor activity
MAIC_00640	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_00650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MAIC_00690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MAIC_00770	COG3757	hydrolase, family 25
MAIC_00860	COG1960	acyl-CoA dehydrogenase activity
MAIC_00880	COG1309	transcriptional regulator
MAIC_00980	COG1595	DNA-templated transcription, initiation
MAIC_01020	COG0346	lactoylglutathione lyase activity
MAIC_01060	COG0494	nUDIX hydrolase
MAIC_01090	COG3237	CsbD-like
MAIC_01160	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MAIC_01180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MAIC_01190	COG0363	glucosamine-6-phosphate deaminase activity
MAIC_01200	COG2190	(PTS) system
MAIC_01210	COG2190	(PTS) system
MAIC_01210	COG1263	PTS System
MAIC_01210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAIC_01250	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_01270	COG2755	lipolytic protein G-D-S-L family
MAIC_01310	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
MAIC_01320	COG1643	Atp-dependent helicase
MAIC_01350	COG1752	Esterase of the alpha-beta hydrolase superfamily
MAIC_01360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_01380	COG1960	acyl-CoA dehydrogenase activity
MAIC_01390	COG1960	acyl-CoA dehydrogenase activity
MAIC_01510	COG2894	cell division
MAIC_01530	COG1404	Belongs to the peptidase S8 family
MAIC_01550	COG0464	growth
MAIC_01570	COG2894	cell division
MAIC_01580	COG0069	glutamate synthase activity
MAIC_01580	COG0070	glutamate synthase
MAIC_01580	COG0067	glutamate synthase
MAIC_01620	COG0659	secondary active sulfate transmembrane transporter activity
MAIC_01640	COG1796	DNA polymerase
MAIC_01640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MAIC_01650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAIC_01660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAIC_01680	COG2072	flavoprotein involved in K transport
MAIC_01690	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MAIC_01790	COG2119	membrane
MAIC_01840	COG1316	TRANSCRIPTIONal
MAIC_01990	COG0204	Acyl-transferase
MAIC_02010	COG0561	phosphatase activity
MAIC_02050	COG1216	Glycosyl transferase, family 2
MAIC_02060	COG0671	phosphoesterase, PA-phosphatase related
MAIC_02070	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MAIC_02080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_02100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MAIC_02160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAIC_02170	COG0243	molybdopterin cofactor binding
MAIC_02180	COG3345	alpha-galactosidase
MAIC_02300	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_02310	COG0277	FAD linked oxidase domain protein
MAIC_02360	COG1216	Glycosyl transferase, family 2
MAIC_02410	COG1063	alcohol dehydrogenase
MAIC_02500	COG2755	lipolytic protein G-D-S-L family
MAIC_02500	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MAIC_02520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_02570	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_02580	COG1960	acyl-CoA dehydrogenase activity
MAIC_02630	COG0745	RESPONSE REGULATOR receiver
MAIC_02640	COG2205	protein histidine kinase activity
MAIC_02650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_02670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_02670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_02700	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MAIC_02710	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_02710	COG3321	synthase
MAIC_02710	COG0604	alcohol dehydrogenase
MAIC_02740	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_02790	COG5416	Lipopolysaccharide assembly protein A domain
MAIC_02810	COG0517	IMP dehydrogenase activity
MAIC_02810	COG1125	glycine betaine transport
MAIC_02820	COG1174	glycine betaine transport
MAIC_02830	COG1174	glycine betaine transport
MAIC_02850	COG0287	Prephenate dehydrogenase
MAIC_02870	COG0590	tRNA wobble adenosine to inosine editing
MAIC_02950	COG0596	Alpha beta hydrolase
MAIC_02960	COG0343	queuine tRNA-ribosyltransferase activity
MAIC_02970	COG2124	cytochrome p450
MAIC_02990	COG1231	oxidoreductase activity
MAIC_03000	COG1126	abc transporter atp-binding protein
MAIC_03010	COG0765	amino acid transport
MAIC_03020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAIC_03050	COG2193	ferroxidase activity
MAIC_03060	COG1937	Protein conserved in bacteria
MAIC_03080	COG1793	dna ligase
MAIC_03100	COG0515	serine threonine protein kinase
MAIC_03100	COG2815	serine threonine protein kinase
MAIC_03200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAIC_03230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_03260	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAIC_03270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MAIC_03290	COG3287	FIST C domain
MAIC_03290	COG2200	EAL domain
MAIC_03290	COG2199	diguanylate cyclase activity
MAIC_03320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MAIC_03330	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MAIC_03370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAIC_03400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAIC_03410	COG0069	glutamate synthase activity
MAIC_03420	COG2218	PFAM glutamate synthase alpha subunit domain protein
MAIC_03430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MAIC_03550	COG1764	response to oxidative stress
MAIC_03570	COG3572	ergothioneine biosynthetic process
MAIC_03580	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MAIC_03590	COG0121	glutamine amidotransferase
MAIC_03600	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MAIC_03610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MAIC_03680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAIC_03720	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
MAIC_03730	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_03760	COG0589	response to stress
MAIC_03760	COG0475	glutathione-regulated potassium exporter activity
MAIC_03830	COG0714	Associated with various cellular activities
MAIC_03890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_03920	COG2890	protein-(glutamine-N5) methyltransferase activity
MAIC_03980	COG0657	acetylesterase activity
MAIC_03990	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_04000	COG0583	DNA-binding transcription factor activity
MAIC_04010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MAIC_04020	COG1408	metallophosphoesterase
MAIC_04030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MAIC_04090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAIC_04120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MAIC_04130	COG3118	belongs to the thioredoxin family
MAIC_04160	COG2226	methyltransferase
MAIC_04160	COG1073	alpha beta
MAIC_04190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAIC_04300	COG1205	dead DEAH box helicase
MAIC_04300	COG1111	helicase
MAIC_04310	COG1278	Cold shock
MAIC_04330	COG1754	DNA topoisomerase type I activity
MAIC_04330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MAIC_04350	COG0470	DNA polymerase III
MAIC_04360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAIC_04400	COG1215	transferase activity, transferring glycosyl groups
MAIC_04520	COG4266	Belongs to the allantoicase family
MAIC_04540	COG1309	transcriptional regulator
MAIC_04590	COG2027	D-alanyl-D-alanine carboxypeptidase
MAIC_04630	COG2197	response regulator
MAIC_04680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MAIC_04700	COG2267	carboxylic ester hydrolase activity
MAIC_04720	COG0302	gtp cyclohydrolase
MAIC_04730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MAIC_04790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MAIC_04800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MAIC_04810	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MAIC_04830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MAIC_04850	COG0542	response to heat
MAIC_04860	COG0393	Putative heavy-metal-binding
MAIC_04950	COG1194	a g-specific adenine glycosylase
MAIC_04980	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MAIC_04990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MAIC_05010	COG1329	Transcriptional regulator
MAIC_05020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MAIC_05030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MAIC_05040	COG0215	cysteine-tRNA ligase activity
MAIC_05050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAIC_05090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MAIC_05100	COG1121	(ABC) transporter
MAIC_05120	COG1609	Transcriptional regulator
MAIC_05140	COG1309	transcriptional regulator
MAIC_05150	COG1960	acyl-CoA dehydrogenase activity
MAIC_05180	COG0346	lactoylglutathione lyase activity
MAIC_05230	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_05240	COG0436	Aminotransferase
MAIC_05260	COG1960	acyl-CoA dehydrogenase activity
MAIC_05270	COG1960	acyl-CoA dehydrogenase activity
MAIC_05280	COG1960	acyl-CoA dehydrogenase activity
MAIC_05290	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_05300	COG1960	acyl-CoA dehydrogenase activity
MAIC_05320	COG1309	transcriptional regulator
MAIC_05330	COG0183	Belongs to the thiolase family
MAIC_05410	COG1024	Enoyl-CoA hydratase
MAIC_05430	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_05460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MAIC_05490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MAIC_05500	COG0531	amino acid
MAIC_05510	COG2364	Membrane
MAIC_05520	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_05540	COG2072	flavoprotein involved in K transport
MAIC_05550	COG0251	oxidation-reduction process
MAIC_05570	COG1473	amidohydrolase
MAIC_05570	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MAIC_05620	COG0183	Belongs to the thiolase family
MAIC_05630	COG2124	cytochrome p450
MAIC_05640	COG1960	acyl-CoA dehydrogenase activity
MAIC_05650	COG1960	acyl-CoA dehydrogenase activity
MAIC_05660	COG2030	dehydratase
MAIC_05710	COG2030	dehydratase
MAIC_05720	COG1053	succinate dehydrogenase
MAIC_05750	COG4569	acetaldehyde dehydrogenase (acetylating) activity
MAIC_05760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAIC_05770	COG0514	ATP-dependent DNA helicase (RecQ)
MAIC_05860	COG4638	Rieske (2fe-2S)
MAIC_05930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_05950	COG2124	cytochrome p450
MAIC_05990	COG2070	2-Nitropropane dioxygenase
MAIC_06010	COG0028	Belongs to the TPP enzyme family
MAIC_06030	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_06040	COG1960	acyl-CoA dehydrogenase activity
MAIC_06050	COG1960	acyl-CoA dehydrogenase activity
MAIC_06070	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_06080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MAIC_06140	COG2084	Dehydrogenase
MAIC_06150	COG1316	TRANSCRIPTIONal
MAIC_06300	COG1960	acyl-CoA dehydrogenase activity
MAIC_06330	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_06350	COG3706	GGDEF domain
MAIC_06370	COG0745	RESPONSE REGULATOR receiver
MAIC_06380	COG5000	phosphorelay sensor kinase activity
MAIC_06380	COG5002	protein histidine kinase activity
MAIC_06410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_06420	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_06480	COG2124	cytochrome p450
MAIC_06490	COG4221	oxidoreductase activity
MAIC_06520	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_06590	COG1403	HNH endonuclease
MAIC_06600	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MAIC_06630	COG4941	Belongs to the sigma-70 factor family
MAIC_06670	COG2124	cytochrome p450
MAIC_06730	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_06750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MAIC_06810	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MAIC_06880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MAIC_06900	COG0386	Belongs to the glutathione peroxidase family
MAIC_06950	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAIC_06960	COG0047	phosphoribosylformylglycinamidine synthase activity
MAIC_06980	COG2837	iron assimilation
MAIC_06990	COG1362	aminopeptidase activity
MAIC_07010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAIC_07070	COG0702	epimerase
MAIC_07100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MAIC_07120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MAIC_07180	COG2897	thiosulfate sulfurtransferase activity
MAIC_07220	COG0745	RESPONSE REGULATOR receiver
MAIC_07230	COG0454	-acetyltransferase
MAIC_07230	COG0456	acetyltransferase
MAIC_07270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MAIC_07360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MAIC_07380	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_07400	COG2072	flavoprotein involved in K transport
MAIC_07420	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_07430	COG1960	acyl-CoA dehydrogenase activity
MAIC_07450	COG0183	Belongs to the thiolase family
MAIC_07460	COG1960	acyl-CoA dehydrogenase activity
MAIC_07490	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_07510	COG1024	Enoyl-CoA hydratase
MAIC_07520	COG1024	Enoyl-CoA hydratase
MAIC_07540	COG2186	Transcriptional regulator
MAIC_07550	COG1024	Enoyl-CoA hydratase
MAIC_07560	COG0183	Belongs to the thiolase family
MAIC_07580	COG0300	oxidoreductase activity
MAIC_07640	COG1960	acyl-CoA dehydrogenase activity
MAIC_07660	COG1960	acyl-CoA dehydrogenase activity
MAIC_07690	COG0183	Belongs to the thiolase family
MAIC_07710	COG2197	response regulator
MAIC_07740	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_07750	COG1063	alcohol dehydrogenase
MAIC_07770	COG0243	molybdopterin cofactor binding
MAIC_07780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_07790	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_07800	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_07810	COG2124	cytochrome p450
MAIC_07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_07850	COG2072	flavoprotein involved in K transport
MAIC_07870	COG1309	transcriptional regulator
MAIC_07930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAIC_07960	COG1902	pentaerythritol trinitrate reductase activity
MAIC_08050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_08090	COG0183	Belongs to the thiolase family
MAIC_08100	COG1250	3-hydroxyacyl-CoA dehydrogenase
MAIC_08100	COG1024	Enoyl-CoA hydratase
MAIC_08120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_08140	COG0183	Belongs to the thiolase family
MAIC_08160	COG1061	Type III restriction enzyme res subunit
MAIC_08200	COG0521	Mo-molybdopterin cofactor biosynthetic process
MAIC_08250	COG3304	Inner membrane component domain
MAIC_08260	COG1278	Cold shock
MAIC_08270	COG0435	Glutathione S-transferase
MAIC_08280	COG1733	regulation of RNA biosynthetic process
MAIC_08310	COG2814	Major facilitator Superfamily
MAIC_08440	COG0477	Major facilitator Superfamily
MAIC_08480	COG1309	transcriptional regulator
MAIC_08490	COG1309	transcriptional regulator
MAIC_08510	COG0477	Major facilitator Superfamily
MAIC_08520	COG1846	Transcriptional regulator
MAIC_08560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MAIC_08570	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_08580	COG2188	Transcriptional regulator
MAIC_08590	COG0545	Peptidyl-prolyl cis-trans isomerase
MAIC_08610	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_08640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MAIC_08680	COG1309	transcriptional regulator
MAIC_08730	COG1132	(ABC) transporter
MAIC_08740	COG1132	(ABC) transporter
MAIC_08750	COG2267	carboxylic ester hydrolase activity
MAIC_08820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MAIC_08930	COG0488	(ABC) transporter
MAIC_08960	COG3287	FIST C domain
MAIC_08960	COG2200	EAL domain
MAIC_08960	COG2199	diguanylate cyclase activity
MAIC_09050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_09060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MAIC_09080	COG1595	DNA-templated transcription, initiation
MAIC_09160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MAIC_09180	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MAIC_09200	COG1793	dna ligase
MAIC_09200	COG3285	dna ligase
MAIC_09210	COG0328	RNA-DNA hybrid ribonuclease activity
MAIC_09290	COG0477	Major facilitator Superfamily
MAIC_09310	COG1950	PFAM Membrane protein of
MAIC_09320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MAIC_09380	COG2755	lipolytic protein G-D-S-L family
MAIC_09380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MAIC_09430	COG0045	succinate-CoA ligase (ADP-forming) activity
MAIC_09560	COG1024	Enoyl-CoA hydratase
MAIC_09590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAIC_09650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAIC_09660	COG0521	Mo-molybdopterin cofactor biosynthetic process
MAIC_09660	COG0315	cyclic pyranopterin monophosphate synthase activity
MAIC_09720	COG5001	Diguanylate cyclase
MAIC_09740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MAIC_09750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MAIC_09790	COG5001	Diguanylate cyclase
MAIC_09830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAIC_09830	COG0456	acetyltransferase
MAIC_09900	COG0406	alpha-ribazole phosphatase activity
MAIC_09930	COG2409	Drug exporters of the RND superfamily
MAIC_09960	COG0644	oxidoreductase
MAIC_09970	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_09990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAIC_09990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MAIC_10000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MAIC_10040	COG5651	PPE family
MAIC_10040	COG3391	amine dehydrogenase activity
MAIC_10050	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MAIC_10110	COG2235	arginine
MAIC_10130	COG2072	flavoprotein involved in K transport
MAIC_10140	COG2072	flavoprotein involved in K transport
MAIC_10150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_10170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_10220	COG1595	DNA-templated transcription, initiation
MAIC_10250	COG0084	hydrolase, TatD family'
MAIC_10260	COG3583	domain protein
MAIC_10280	COG0515	serine threonine protein kinase
MAIC_10290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MAIC_10300	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_10350	COG0193	aminoacyl-tRNA hydrolase activity
MAIC_10360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MAIC_10390	COG1393	Belongs to the ArsC family
MAIC_10440	COG3956	TIGRFAM MazG family protein
MAIC_10450	COG2837	iron assimilation
MAIC_10460	COG2822	iron ion transport
MAIC_10470	COG0672	)-iron permease
MAIC_10560	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MAIC_10570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MAIC_10580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MAIC_10600	COG1088	dTDP-glucose 4,6-dehydratase activity
MAIC_10640	COG3852	Histidine kinase
MAIC_10650	COG3634	alkyl hydroperoxide reductase activity
MAIC_10660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MAIC_10670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MAIC_10680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MAIC_10690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MAIC_10700	COG0202	RNA polymerase activity
MAIC_10800	COG1404	Belongs to the peptidase S8 family
MAIC_10830	COG1674	ftsk spoiiie
MAIC_10850	COG4842	Belongs to the WXG100 family
MAIC_10860	COG4842	Belongs to the WXG100 family
MAIC_10920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MAIC_10930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MAIC_10950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAIC_10980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_11000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MAIC_11050	COG0076	glutamate decarboxylase activity
MAIC_11060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MAIC_11110	COG2188	Transcriptional regulator
MAIC_11160	COG0456	acetyltransferase
MAIC_11170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MAIC_11190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MAIC_11400	COG0516	GMP reductase activity
MAIC_11450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MAIC_11450	COG0519	Catalyzes the synthesis of GMP from XMP
MAIC_11470	COG3588	fructose-bisphosphate aldolase
MAIC_11550	COG0406	alpha-ribazole phosphatase activity
MAIC_11560	COG2030	dehydratase
MAIC_11610	COG3973	AAA domain
MAIC_11620	COG0587	DNA-directed DNA polymerase activity
MAIC_11660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MAIC_11690	COG2205	protein histidine kinase activity
MAIC_11700	COG2018	Roadblock/LC7 domain
MAIC_11730	COG1357	PFAM Pentapeptide repeats (8 copies)
MAIC_11800	COG1716	ATPase activity
MAIC_11800	COG1131	(ABC) transporter
MAIC_11800	COG0842	Transport permease protein
MAIC_11810	COG1902	pentaerythritol trinitrate reductase activity
MAIC_11810	COG0446	pyridine nucleotide-disulphide oxidoreductase
MAIC_11840	COG1309	transcriptional regulator
MAIC_11860	COG3706	GGDEF domain
MAIC_11870	COG5001	Diguanylate cyclase
MAIC_11900	COG2873	o-acetylhomoserine
MAIC_12010	COG1295	ribonuclease BN
MAIC_12080	COG1686	Belongs to the peptidase S11 family
MAIC_12100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MAIC_12130	COG1309	transcriptional regulator
MAIC_12150	COG0765	amino acid transport
MAIC_12180	COG3619	membrane
MAIC_12200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAIC_12210	COG1960	acyl-CoA dehydrogenase activity
MAIC_12230	COG2030	dehydratase
MAIC_12270	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_12280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MAIC_12290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MAIC_12320	COG2009	succinate dehydrogenase
MAIC_12400	COG5651	PPE family
MAIC_12440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAIC_12460	COG3180	Ammonia monooxygenase
MAIC_12490	COG1473	amidohydrolase
MAIC_12490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MAIC_12540	COG0564	pseudouridine synthase activity
MAIC_12580	COG1201	RNA secondary structure unwinding
MAIC_12600	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MAIC_12600	COG1672	PFAM Archaeal ATPase
MAIC_12640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAIC_12660	COG0596	Alpha beta hydrolase
MAIC_12670	COG1309	transcriptional regulator
MAIC_12690	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_12710	COG1522	sequence-specific DNA binding
MAIC_12760	COG0723	plastoquinol--plastocyanin reductase activity
MAIC_12760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAIC_12770	COG0297	glycogen (starch) synthase activity
MAIC_12840	COG4770	biotin carboxylase activity
MAIC_12890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAIC_12920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MAIC_12930	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MAIC_12950	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MAIC_12950	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MAIC_12980	COG1316	TRANSCRIPTIONal
MAIC_13010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MAIC_13080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAIC_13100	COG1482	cell wall glycoprotein biosynthetic process
MAIC_13120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_13130	COG0531	amino acid
MAIC_13140	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAIC_13180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MAIC_13220	COG0745	RESPONSE REGULATOR receiver
MAIC_13240	COG5401	PFAM Sporulation and spore germination
MAIC_13340	COG0596	Alpha beta hydrolase
MAIC_13360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MAIC_13370	COG0653	protein targeting
MAIC_13400	COG2326	polyphosphate kinase activity
MAIC_13440	COG0656	L-ascorbic acid biosynthetic process
MAIC_13450	COG1162	GTPase activity
MAIC_13460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MAIC_13470	COG2135	peptidase activity
MAIC_13500	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_13510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MAIC_13520	COG1595	DNA-templated transcription, initiation
MAIC_13530	COG5662	AntiSigma factor
MAIC_13540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MAIC_13570	COG1597	lipid kinase activity
MAIC_13590	COG1309	transcriptional regulator
MAIC_13640	COG0406	alpha-ribazole phosphatase activity
MAIC_13670	COG0513	Belongs to the DEAD box helicase family
MAIC_13760	COG0596	Alpha beta hydrolase
MAIC_13800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MAIC_13890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MAIC_13920	COG3480	Lon protease (S16) C-terminal proteolytic domain
MAIC_13940	COG1234	tRNA 3'-trailer cleavage
MAIC_13970	COG1396	sequence-specific DNA binding
MAIC_13980	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
MAIC_13990	COG0582	viral genome integration into host DNA
MAIC_14230	COG3707	response regulator
MAIC_14290	COG0583	DNA-binding transcription factor activity
MAIC_14300	COG2814	Major facilitator Superfamily
MAIC_14420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_14460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAIC_14480	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_14490	COG2409	Drug exporters of the RND superfamily
MAIC_14510	COG2226	methyltransferase
MAIC_14520	COG2124	cytochrome p450
MAIC_14530	COG0789	Transcriptional regulator
MAIC_14610	COG0778	Nitroreductase
MAIC_14680	COG0300	oxidoreductase activity
MAIC_14700	COG1024	Enoyl-CoA hydratase
MAIC_14740	COG0713	ATP synthesis coupled electron transport
MAIC_14760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAIC_14770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MAIC_14780	COG1034	ATP synthesis coupled electron transport
MAIC_14820	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAIC_14830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MAIC_14900	COG1960	acyl-CoA dehydrogenase activity
MAIC_14920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_14940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAIC_14950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_14980	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MAIC_14990	COG0604	alcohol dehydrogenase
MAIC_15020	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_15040	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_15080	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_15110	COG2124	cytochrome p450
MAIC_15120	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_15140	COG0243	molybdopterin cofactor binding
MAIC_15160	COG0667	Aldo Keto reductase
MAIC_15170	COG1960	acyl-CoA dehydrogenase activity
MAIC_15180	COG1960	acyl-CoA dehydrogenase activity
MAIC_15190	COG0483	inositol monophosphate 1-phosphatase activity
MAIC_15270	COG0668	transmembrane transport
MAIC_15290	COG2884	Cell division ATP-binding protein ftsE
MAIC_15300	COG2177	Part of the ABC transporter FtsEX involved in
MAIC_15310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MAIC_15700	COG1032	radical SAM domain protein
MAIC_15770	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAIC_15820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_15830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_15840	COG0784	Response regulator, receiver
MAIC_15850	COG4251	negative regulation of phosphorylation
MAIC_15970	COG2814	Major facilitator Superfamily
MAIC_16040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAIC_16090	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_16120	COG2267	carboxylic ester hydrolase activity
MAIC_16140	COG0277	FAD linked oxidase domain protein
MAIC_16170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MAIC_16190	COG0235	Class ii aldolase
MAIC_16200	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_16220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MAIC_16220	COG0574	Belongs to the PEP-utilizing enzyme family
MAIC_16320	COG2072	flavoprotein involved in K transport
MAIC_16330	COG0596	Alpha beta hydrolase
MAIC_16340	COG3119	arylsulfatase activity
MAIC_16360	COG2267	carboxylic ester hydrolase activity
MAIC_16410	COG0179	Fumarylacetoacetate (FAA) hydrolase
MAIC_16420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_16490	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_16500	COG1960	acyl-CoA dehydrogenase activity
MAIC_16510	COG1960	acyl-CoA dehydrogenase activity
MAIC_16540	COG1966	Carbon starvation protein
MAIC_16550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAIC_16560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_16600	COG1960	acyl-CoA dehydrogenase activity
MAIC_16680	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_16720	COG0431	NADPH-dependent FMN reductase
MAIC_16810	COG0583	DNA-binding transcription factor activity
MAIC_16830	COG3384	dioxygenase
MAIC_16860	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_16870	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_16900	COG1309	transcriptional regulator
MAIC_16940	COG1335	isochorismatase
MAIC_16950	COG0596	Alpha beta hydrolase
MAIC_16970	COG2267	carboxylic ester hydrolase activity
MAIC_16990	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_17030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_17060	COG1064	alcohol dehydrogenase
MAIC_17110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAIC_17130	COG2364	Membrane
MAIC_17140	COG1119	ATPase activity
MAIC_17200	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MAIC_17210	COG0110	maltose O-acetyltransferase activity
MAIC_17250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MAIC_17270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MAIC_17310	COG0482	sulfurtransferase activity
MAIC_17410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_17460	COG0714	Associated with various cellular activities
MAIC_17530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAIC_17540	COG0154	amidase activity
MAIC_17560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAIC_17620	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
MAIC_17720	COG0375	protein maturation
MAIC_17730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
MAIC_17740	COG0298	carbon dioxide binding
MAIC_17750	COG0409	Hydrogenase expression formation protein
MAIC_17780	COG3958	Transketolase
MAIC_17790	COG3959	Transketolase, thiamine diphosphate binding domain
MAIC_17820	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_17830	COG2376	Dihydroxyacetone kinase
MAIC_17840	COG0698	ribose 5-phosphate isomerase
MAIC_17850	COG1309	transcriptional regulator
MAIC_17910	COG0440	acetolactate synthase activity
MAIC_17950	COG0473	3-isopropylmalate dehydrogenase activity
MAIC_17960	COG2271	Major facilitator Superfamily
MAIC_17970	COG0179	Fumarylacetoacetate (FAA) hydrolase
MAIC_17980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAIC_18010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAIC_18050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MAIC_18060	COG1920	GTP binding
MAIC_18080	COG0626	cystathionine gamma-synthase activity
MAIC_18090	COG1181	Belongs to the D-alanine--D-alanine ligase family
MAIC_18150	COG1461	Dihydroxyacetone kinase
MAIC_18180	COG1959	2 iron, 2 sulfur cluster binding
MAIC_18190	COG1017	nitric oxide dioxygenase activity
MAIC_18190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MAIC_18200	COG0656	L-ascorbic acid biosynthetic process
MAIC_18250	COG0742	ribosomal rna small subunit methyltransferase
MAIC_18260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MAIC_18300	COG0571	ribonuclease III activity
MAIC_18310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MAIC_18330	COG1254	Belongs to the acylphosphatase family
MAIC_18360	COG2208	phosphoserine phosphatase activity
MAIC_18380	COG1304	FMN binding
MAIC_18420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MAIC_18430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MAIC_18460	COG1686	Belongs to the peptidase S11 family
MAIC_18480	COG1686	Belongs to the peptidase S11 family
MAIC_18530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MAIC_18540	COG0336	Belongs to the RNA methyltransferase TrmD family
MAIC_18570	COG0335	large ribosomal subunit rRNA binding
MAIC_18620	COG2814	Major facilitator Superfamily
MAIC_18730	COG1937	Protein conserved in bacteria
MAIC_18740	COG4974	Belongs to the 'phage' integrase family
MAIC_18750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MAIC_18770	COG0052	Belongs to the universal ribosomal protein uS2 family
MAIC_18790	COG0154	amidase activity
MAIC_18820	COG1136	(ABC) transporter
MAIC_18910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MAIC_18930	COG0415	Belongs to the DNA photolyase family
MAIC_18970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MAIC_18980	COG0750	zinc metalloprotease
MAIC_18990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MAIC_19110	COG0367	asparagine synthase
MAIC_19140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MAIC_19160	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_19170	COG2186	Transcriptional regulator
MAIC_19180	COG1063	alcohol dehydrogenase
MAIC_19230	COG2860	membrane
MAIC_19240	COG1473	amidohydrolase
MAIC_19330	COG0310	cobalt ion transport
MAIC_19360	COG1122	ATPase activity
MAIC_19390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAIC_19410	COG1349	DNA-binding transcription factor activity
MAIC_19490	COG1648	precorrin-2 dehydrogenase activity
MAIC_19490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MAIC_19590	COG0779	Required for maturation of 30S ribosomal subunits
MAIC_19640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MAIC_19660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MAIC_19670	COG3979	chitinase
MAIC_19680	COG1024	Enoyl-CoA hydratase
MAIC_19700	COG1309	transcriptional regulator
MAIC_19760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MAIC_19810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MAIC_19870	COG0686	Belongs to the AlaDH PNT family
MAIC_19880	COG1522	sequence-specific DNA binding
MAIC_19890	COG3391	amine dehydrogenase activity
MAIC_19890	COG5651	PPE family
MAIC_20000	COG0142	geranyltranstransferase activity
MAIC_20080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MAIC_20090	COG3214	Protein conserved in bacteria
MAIC_20100	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_20110	COG3706	GGDEF domain
MAIC_20130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MAIC_20170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MAIC_20230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MAIC_20250	COG1058	Belongs to the CinA family
MAIC_20250	COG1546	Belongs to the CinA family
MAIC_20260	COG1396	sequence-specific DNA binding
MAIC_20290	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
MAIC_20330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MAIC_20370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_20400	COG0765	amino acid transport
MAIC_20410	COG0765	amino acid transport
MAIC_20420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAIC_20430	COG1126	abc transporter atp-binding protein
MAIC_20440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MAIC_20460	COG1196	nuclear chromosome segregation
MAIC_20470	COG0697	spore germination
MAIC_20490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MAIC_20500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MAIC_20510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MAIC_20520	COG5651	PPE family
MAIC_20520	COG3391	amine dehydrogenase activity
MAIC_20540	COG1960	acyl-CoA dehydrogenase activity
MAIC_20560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MAIC_20570	COG1388	LysM domain
MAIC_20580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MAIC_20740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MAIC_20770	COG0483	inositol monophosphate 1-phosphatase activity
MAIC_20810	COG0756	dUTP diphosphatase activity
MAIC_20880	COG0569	domain protein
MAIC_20890	COG0531	amino acid
MAIC_20900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MAIC_20930	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MAIC_20950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MAIC_21010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAIC_21170	COG0745	RESPONSE REGULATOR receiver
MAIC_21220	COG0745	RESPONSE REGULATOR receiver
MAIC_21240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MAIC_21490	COG1022	Amp-dependent synthetase and ligase
MAIC_21510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MAIC_21560	COG0596	Alpha beta hydrolase
MAIC_21570	COG1864	DNA RNA non-specific endonuclease
MAIC_21570	COG3591	Belongs to the peptidase S1B family
MAIC_21680	COG1366	Belongs to the anti-sigma-factor antagonist family
MAIC_21720	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_21770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAIC_21840	COG4762	Protein conserved in bacteria
MAIC_21870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MAIC_21890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAIC_21900	COG1560	Kdo2-lipid A biosynthetic process
MAIC_21910	COG0438	transferase activity, transferring glycosyl groups
MAIC_21940	COG1946	Acyl-CoA thioesterase
MAIC_21950	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MAIC_22000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAIC_22030	COG2124	cytochrome p450
MAIC_22040	COG0129	dihydroxy-acid dehydratase activity
MAIC_22080	COG3226	Transcriptional regulator
MAIC_22130	COG1414	Transcriptional regulator
MAIC_22150	COG0243	molybdopterin cofactor binding
MAIC_22220	COG2255	four-way junction helicase activity
MAIC_22250	COG3320	Male sterility
MAIC_22250	COG1022	Amp-dependent synthetase and ligase
MAIC_22280	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_22290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAIC_22330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAIC_22340	COG0747	negative chemotaxis
MAIC_22350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAIC_22360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MAIC_22390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAIC_22420	COG0124	histidyl-tRNA synthetase
MAIC_22460	COG0753	catalase activity
MAIC_22510	COG0683	leucine binding
MAIC_22590	COG1960	acyl-CoA dehydrogenase activity
MAIC_22650	COG2272	Belongs to the type-B carboxylesterase lipase family
MAIC_22670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MAIC_22710	COG0183	Belongs to the thiolase family
MAIC_22720	COG1733	regulation of RNA biosynthetic process
MAIC_22830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MAIC_22890	COG1960	acyl-CoA dehydrogenase activity
MAIC_22900	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_22920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_23010	COG0432	Pfam Uncharacterised protein family UPF0047
MAIC_23020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MAIC_23030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MAIC_23050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MAIC_23070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MAIC_23130	COG0714	Associated with various cellular activities
MAIC_23170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MAIC_23190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MAIC_23210	COG0006	proline dipeptidase activity
MAIC_23220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MAIC_23250	COG1960	acyl-CoA dehydrogenase activity
MAIC_23260	COG0434	BtpA family
MAIC_23270	COG1349	DNA-binding transcription factor activity
MAIC_23320	COG0395	ABC-type sugar transport system, permease component
MAIC_23330	COG3842	ATPase activity
MAIC_23390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MAIC_23400	COG0540	Belongs to the ATCase OTCase family
MAIC_23430	COG0505	Belongs to the CarA family
MAIC_23450	COG0284	orotidine-5'-phosphate decarboxylase activity
MAIC_23490	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
MAIC_23530	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_23600	COG1704	LemA family
MAIC_23610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MAIC_23650	COG0693	protein deglycase activity
MAIC_23680	COG0601	transmembrane transport
MAIC_23690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MAIC_23700	COG0444	Belongs to the ABC transporter superfamily
MAIC_23710	COG4608	Belongs to the ABC transporter superfamily
MAIC_23720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAIC_23740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MAIC_23750	COG1070	Carbohydrate kinase
MAIC_23760	COG0363	glucosamine-6-phosphate deaminase activity
MAIC_23770	COG0019	diaminopimelate decarboxylase activity
MAIC_23780	COG0477	Major facilitator Superfamily
MAIC_23830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAIC_23830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAIC_23870	COG0322	excinuclease ABC activity
MAIC_23880	COG1660	Displays ATPase and GTPase activities
MAIC_23900	COG1481	regulation of sporulation
MAIC_23930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MAIC_23940	COG0126	phosphoglycerate kinase activity
MAIC_23950	COG0149	triose-phosphate isomerase activity
MAIC_24000	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MAIC_24070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MAIC_24090	COG0109	protoheme IX farnesyltransferase activity
MAIC_24190	COG0396	ATPase activity
MAIC_24220	COG2151	metal-sulfur cluster biosynthetic enzyme
MAIC_24260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAIC_24280	COG0488	(ABC) transporter
MAIC_24310	COG1309	transcriptional regulator
MAIC_24320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MAIC_24340	COG0791	NLP P60 protein
MAIC_24340	COG3883	PFAM NLP P60 protein
MAIC_24360	COG0714	Associated with various cellular activities
MAIC_24380	COG2304	oxidoreductase activity
MAIC_24390	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_24400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MAIC_24550	COG3321	synthase
MAIC_24550	COG0604	alcohol dehydrogenase
MAIC_24550	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_24640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MAIC_24660	COG0252	asparaginase activity
MAIC_24670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MAIC_24720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAIC_24760	COG1305	Transglutaminase-like
MAIC_24810	COG0477	Major facilitator Superfamily
MAIC_24830	COG0243	molybdopterin cofactor binding
MAIC_24840	COG2223	nitrite transmembrane transporter activity
MAIC_24850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAIC_24850	COG2146	nitrite reductase [NAD(P)H] activity
MAIC_24990	COG1309	transcriptional regulator
MAIC_25000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MAIC_25050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MAIC_25080	COG1280	lysine exporter protein (LysE YggA)
MAIC_25110	COG0131	Imidazoleglycerol-phosphate dehydratase
MAIC_25120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MAIC_25130	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MAIC_25140	COG0483	inositol monophosphate 1-phosphatase activity
MAIC_25150	COG0107	imidazoleglycerol-phosphate synthase activity
MAIC_25160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MAIC_25170	COG0277	FAD linked oxidase domain protein
MAIC_25180	COG1119	ATPase activity
MAIC_25220	COG0134	indole-3-glycerol-phosphate synthase activity
MAIC_25270	COG1309	transcriptional regulator
MAIC_25300	COG1309	transcriptional regulator
MAIC_25350	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_25370	COG1309	transcriptional regulator
MAIC_25400	COG0640	Transcriptional regulator
MAIC_25530	COG4122	O-methyltransferase activity
MAIC_25550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAIC_25560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAIC_25600	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MAIC_25620	COG2378	regulation of single-species biofilm formation
MAIC_25630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAIC_25710	COG0300	oxidoreductase activity
MAIC_25810	COG0714	Associated with various cellular activities
MAIC_25890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MAIC_25910	COG0463	Glycosyl transferase, family 2
MAIC_25950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MAIC_25980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_26000	COG0640	Transcriptional regulator
MAIC_26100	COG3265	gluconokinase activity
MAIC_26180	COG2226	methyltransferase
MAIC_26190	COG0438	transferase activity, transferring glycosyl groups
MAIC_26210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAIC_26220	COG1335	isochorismatase
MAIC_26250	COG2020	methyltransferase activity
MAIC_26260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MAIC_26290	COG1177	transmembrane transport
MAIC_26300	COG1176	ABC-type spermidine putrescine transport system, permease component I
MAIC_26330	COG1960	acyl-CoA dehydrogenase activity
MAIC_26360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_26370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_26420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAIC_26450	COG1053	succinate dehydrogenase
MAIC_26460	COG3842	ATPase activity
MAIC_26470	COG0395	ABC-type sugar transport system, permease component
MAIC_26480	COG1175	transmembrane transport
MAIC_26490	COG2182	Extracellular solute-binding protein
MAIC_26500	COG1486	melibiose metabolic process
MAIC_26530	COG2222	sugar isomerase
MAIC_26590	COG1053	succinate dehydrogenase
MAIC_26670	COG0300	oxidoreductase activity
MAIC_26690	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_26700	COG1960	acyl-CoA dehydrogenase activity
MAIC_26710	COG2072	flavoprotein involved in K transport
MAIC_26720	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_26790	COG0346	lactoylglutathione lyase activity
MAIC_26820	COG2072	flavoprotein involved in K transport
MAIC_26840	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_26860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_26880	COG1024	Enoyl-CoA hydratase
MAIC_26890	COG1403	HNH endonuclease
MAIC_26930	COG0346	lactoylglutathione lyase activity
MAIC_26950	COG2072	flavoprotein involved in K transport
MAIC_26970	COG5002	protein histidine kinase activity
MAIC_26980	COG0668	transmembrane transport
MAIC_26990	COG0579	oxidoreductase
MAIC_27040	COG2814	Major facilitator Superfamily
MAIC_27090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MAIC_27320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MAIC_27390	COG3757	hydrolase, family 25
MAIC_27430	COG3011	Protein conserved in bacteria
MAIC_27470	COG1252	NADH dehydrogenase
MAIC_27500	COG2409	Drug exporters of the RND superfamily
MAIC_27590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAIC_27610	COG0545	Peptidyl-prolyl cis-trans isomerase
MAIC_27720	COG1755	Isoprenylcysteine carboxyl methyltransferase
MAIC_27820	COG0791	NLP P60 protein
MAIC_27820	COG3883	PFAM NLP P60 protein
MAIC_27910	COG0058	SHG alpha-glucan phosphorylase activity
MAIC_27920	COG1063	alcohol dehydrogenase
MAIC_27970	COG4948	Mandelate Racemase Muconate Lactonizing
MAIC_28010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MAIC_28090	COG0667	Aldo Keto reductase
MAIC_28130	COG0646	methionine synthase
MAIC_28130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MAIC_28150	COG2134	cdp-diacylglycerol pyrophosphatase
MAIC_28160	COG3585	molybdate ion transport
MAIC_28200	COG3022	response to hydroperoxide
MAIC_28230	COG0010	Belongs to the arginase family
MAIC_28430	COG3250	beta-galactosidase activity
MAIC_28440	COG0697	spore germination
MAIC_28510	COG2070	2-Nitropropane dioxygenase
MAIC_28570	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_28590	COG2124	cytochrome p450
MAIC_28670	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_28720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_28740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAIC_28750	COG1605	Chorismate mutase
MAIC_28770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_28830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MAIC_28880	COG0438	transferase activity, transferring glycosyl groups
MAIC_28900	COG0412	Dienelactone hydrolase
MAIC_28920	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_28940	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
MAIC_28990	COG0174	glutamine synthetase
MAIC_29020	COG2193	ferroxidase activity
MAIC_29030	COG1024	Enoyl-CoA hydratase
MAIC_29200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_29250	COG0183	Belongs to the thiolase family
MAIC_29290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_29300	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MAIC_29350	COG2261	transglycosylase associated protein
MAIC_29400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_29430	COG2205	protein histidine kinase activity
MAIC_29440	COG0829	nickel cation binding
MAIC_29450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MAIC_29470	COG0804	urea catabolic process
MAIC_29540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MAIC_29560	COG1253	flavin adenine dinucleotide binding
MAIC_29570	COG1253	flavin adenine dinucleotide binding
MAIC_29580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MAIC_29630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MAIC_29630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MAIC_29680	COG0509	glycine decarboxylation via glycine cleavage system
MAIC_29760	COG3976	FMN-binding domain protein
MAIC_29760	COG1053	succinate dehydrogenase
MAIC_29810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAIC_29820	COG4651	solute:proton antiporter activity
MAIC_29820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MAIC_29850	COG2272	Belongs to the type-B carboxylesterase lipase family
MAIC_29870	COG2076	Multidrug Resistance protein
MAIC_29960	COG4266	Belongs to the allantoicase family
MAIC_29980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MAIC_30030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MAIC_30050	COG1309	transcriptional regulator
MAIC_30070	COG3046	protein related to deoxyribodipyrimidine photolyase
MAIC_30150	COG1846	Transcriptional regulator
MAIC_30160	COG2323	membrane
MAIC_30190	COG0028	Belongs to the TPP enzyme family
MAIC_30200	COG0277	FAD linked oxidase domain protein
MAIC_30200	COG0247	lactate metabolic process
MAIC_30210	COG4948	Mandelate Racemase Muconate Lactonizing
MAIC_30220	COG0297	glycogen (starch) synthase activity
MAIC_30240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_30260	COG0300	oxidoreductase activity
MAIC_30300	COG1233	COG1233 Phytoene dehydrogenase and related
MAIC_30320	COG0477	Major facilitator Superfamily
MAIC_30330	COG1490	D-aminoacyl-tRNA deacylase activity
MAIC_30360	COG1960	acyl-CoA dehydrogenase activity
MAIC_30370	COG1960	acyl-CoA dehydrogenase activity
MAIC_30380	COG1960	acyl-CoA dehydrogenase activity
MAIC_30390	COG1960	acyl-CoA dehydrogenase activity
MAIC_30400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_30410	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_30420	COG2072	flavoprotein involved in K transport
MAIC_30470	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_30490	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_30500	COG1024	Enoyl-CoA hydratase
MAIC_30520	COG0531	amino acid
MAIC_30620	COG2252	PERMEase
MAIC_30630	COG2188	Transcriptional regulator
MAIC_30820	COG2226	methyltransferase
MAIC_30870	COG0277	FAD linked oxidase domain protein
MAIC_30920	COG1309	transcriptional regulator
MAIC_30970	COG4689	acetoacetate decarboxylase
MAIC_31030	COG1160	GTP binding
MAIC_31040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MAIC_31060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MAIC_31070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MAIC_31110	COG0504	CTP synthase activity
MAIC_31190	COG0647	UMP catabolic process
MAIC_31260	COG2835	tetraacyldisaccharide 4'-kinase activity
MAIC_31290	COG0488	(ABC) transporter
MAIC_31340	COG0165	Argininosuccinate lyase
MAIC_31350	COG0137	argininosuccinate synthase activity
MAIC_31370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MAIC_31380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MAIC_31390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MAIC_31400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MAIC_31410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MAIC_31420	COG0072	phenylalanine-tRNA ligase activity
MAIC_31420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAIC_31430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MAIC_31440	COG0069	glutamate synthase activity
MAIC_31460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MAIC_31500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAIC_31580	COG1960	acyl-CoA dehydrogenase activity
MAIC_31600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MAIC_31610	COG2080	2 iron, 2 sulfur cluster binding
MAIC_31620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MAIC_31650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MAIC_31660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MAIC_31720	COG4221	oxidoreductase activity
MAIC_31740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAIC_31780	COG0598	Magnesium transport protein CorA
MAIC_31860	COG1285	pathogenesis
MAIC_31930	COG0539	negative regulation of cytoplasmic translation
MAIC_31950	COG2860	membrane
MAIC_32000	COG1872	DUF167
MAIC_32120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAIC_32170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAIC_32200	COG1271	oxidase subunit
MAIC_32210	COG1294	oxidase, subunit
MAIC_32220	COG4988	ABC transporter
MAIC_32230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MAIC_32260	COG1946	Acyl-CoA thioesterase
MAIC_32290	COG0070	glutamate synthase
MAIC_32290	COG0069	glutamate synthase activity
MAIC_32290	COG0067	glutamate synthase
MAIC_32330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MAIC_32350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MAIC_32380	COG0477	Major facilitator Superfamily
MAIC_32400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MAIC_32440	COG0646	methionine synthase
MAIC_32440	COG1410	methionine synthase
MAIC_32460	COG1403	HNH endonuclease
MAIC_32470	COG1960	acyl-CoA dehydrogenase activity
MAIC_32480	COG1960	acyl-CoA dehydrogenase activity
MAIC_32490	COG0215	cysteine-tRNA ligase activity
MAIC_32500	COG1218	3'(2'),5'-bisphosphate nucleotidase
MAIC_32540	COG1968	undecaprenyl-diphosphatase activity
MAIC_32580	COG0167	dihydroorotate dehydrogenase activity
MAIC_32620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAIC_32660	COG0596	Alpha beta hydrolase
MAIC_32690	COG0583	DNA-binding transcription factor activity
MAIC_32770	COG0589	response to stress
MAIC_32810	COG3290	protein histidine kinase activity
MAIC_32820	COG4565	transcriptional regulatory protein
MAIC_32870	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_32880	COG0519	Catalyzes the synthesis of GMP from XMP
MAIC_32880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MAIC_32960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MAIC_33030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MAIC_33070	COG0768	penicillin binding
MAIC_33090	COG0275	rRNA processing
MAIC_33180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MAIC_33210	COG5650	phosphatidylinositol metabolic process
MAIC_33360	COG1845	cytochrome c oxidase, subunit III
MAIC_33460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAIC_33520	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MAIC_33550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAIC_33560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MAIC_33620	COG0321	lipoyl(octanoyl) transferase activity
MAIC_33680	COG0174	glutamine synthetase
MAIC_33700	COG0288	reversible hydration of carbon dioxide
MAIC_33720	COG3002	Belongs to the UPF0753 family
MAIC_33730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MAIC_33770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MAIC_33780	COG0174	glutamine synthetase
MAIC_33810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAIC_33830	COG1024	Enoyl-CoA hydratase
MAIC_33970	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MAIC_34050	COG2070	2-Nitropropane dioxygenase
MAIC_34060	COG2807	transmembrane transport
MAIC_34070	COG2186	Transcriptional regulator
MAIC_34130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAIC_34170	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MAIC_34190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MAIC_34200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAIC_34210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MAIC_34240	COG2207	Transcriptional regulator
MAIC_34250	COG0667	Aldo Keto reductase
MAIC_34260	COG1113	amino acid transport
MAIC_34550	COG4172	Belongs to the ABC transporter superfamily
MAIC_34570	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_34750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_34770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MAIC_34780	COG4521	taurine ABC transporter
MAIC_34790	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MAIC_34810	COG1033	growth of symbiont in host cell
MAIC_34810	COG2409	Drug exporters of the RND superfamily
MAIC_34820	COG2409	Drug exporters of the RND superfamily
MAIC_34820	COG1033	growth of symbiont in host cell
MAIC_35010	COG1175	transmembrane transport
MAIC_35020	COG0395	ABC-type sugar transport system, permease component
MAIC_35070	COG2814	Major facilitator Superfamily
MAIC_35080	COG3781	membrane
MAIC_35100	COG1960	acyl-CoA dehydrogenase activity
MAIC_35160	COG0358	DNA primase activity
MAIC_35190	COG0423	glycine-tRNA ligase activity
MAIC_35290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MAIC_35330	COG2197	response regulator
MAIC_35350	COG0484	heat shock protein binding
MAIC_35360	COG1420	regulation of RNA biosynthetic process
MAIC_35380	COG2205	protein histidine kinase activity
MAIC_35390	COG0745	RESPONSE REGULATOR receiver
MAIC_35400	COG0659	secondary active sulfate transmembrane transporter activity
MAIC_35470	COG4208	sulfate ABC transporter
MAIC_35480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MAIC_35490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MAIC_35510	COG3387	PFAM Glycoside hydrolase 15-related
MAIC_35530	COG2814	Major facilitator Superfamily
MAIC_35580	COG0516	GMP reductase activity
MAIC_35580	COG0517	IMP dehydrogenase activity
MAIC_35590	COG0667	Aldo Keto reductase
MAIC_35600	COG1309	transcriptional regulator
MAIC_35620	COG0174	glutamine synthetase
MAIC_35630	COG1234	tRNA 3'-trailer cleavage
MAIC_35650	COG1305	Transglutaminase-like
MAIC_35710	COG1555	photosystem II stabilization
MAIC_35710	COG1596	polysaccharide export
MAIC_35750	COG2755	lipolytic protein G-D-S-L family
MAIC_35770	COG0799	negative regulation of ribosome biogenesis
MAIC_35780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MAIC_35790	COG3391	amine dehydrogenase activity
MAIC_35790	COG5651	PPE family
MAIC_35810	COG0542	response to heat
MAIC_35820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MAIC_35830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAIC_35920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MAIC_35930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MAIC_35940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MAIC_35950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MAIC_35960	COG1530	ribonuclease E activity
MAIC_35970	COG0105	UTP biosynthetic process
MAIC_35990	COG0285	dihydrofolate synthase activity
MAIC_36000	COG0525	valine-tRNA ligase activity
MAIC_36020	COG3268	Saccharopine dehydrogenase
MAIC_36030	COG0823	Involved in the tonB-independent uptake of proteins
MAIC_36030	COG1506	peptidase
MAIC_36050	COG1388	LysM domain
MAIC_36060	COG1388	LysM domain
MAIC_36070	COG0746	molybdenum cofactor guanylyltransferase activity
MAIC_36080	COG1013	pyruvate-flavodoxin oxidoreductase activity
MAIC_36090	COG0674	pyruvate-flavodoxin oxidoreductase activity
MAIC_36090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MAIC_36100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAIC_36110	COG1609	Transcriptional regulator
MAIC_36130	COG0673	inositol 2-dehydrogenase activity
MAIC_36180	COG1172	Belongs to the binding-protein-dependent transport system permease family
MAIC_36230	COG2188	Transcriptional regulator
MAIC_36260	COG3718	enzyme involved in inositol metabolism
MAIC_36270	COG3962	Belongs to the TPP enzyme family
MAIC_36290	COG0673	inositol 2-dehydrogenase activity
MAIC_36320	COG0730	response to heat
MAIC_36330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAIC_36340	COG1252	NADH dehydrogenase
MAIC_36350	COG3453	Protein conserved in bacteria
MAIC_36350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAIC_36360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MAIC_36440	COG0740	serine-type endopeptidase activity
MAIC_36450	COG0740	serine-type endopeptidase activity
MAIC_36460	COG0544	peptidyl-prolyl cis-trans isomerase activity
MAIC_36520	COG1231	oxidoreductase activity
MAIC_36590	COG0698	ribose 5-phosphate isomerase
MAIC_36610	COG0667	Aldo Keto reductase
MAIC_36650	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MAIC_36680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MAIC_36720	COG0366	Alpha amylase catalytic
MAIC_36760	COG2902	Dehydrogenase
MAIC_36860	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_36930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_36980	COG1595	DNA-templated transcription, initiation
MAIC_37010	COG0549	Belongs to the carbamate kinase family
MAIC_37020	COG1304	FMN binding
MAIC_37030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MAIC_37040	COG1335	isochorismatase
MAIC_37060	COG3629	intracellular signal transduction
MAIC_37080	COG0640	Transcriptional regulator
MAIC_37090	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAIC_37140	COG1960	acyl-CoA dehydrogenase activity
MAIC_37160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAIC_37170	COG1309	transcriptional regulator
MAIC_37230	COG4221	oxidoreductase activity
MAIC_37240	COG0433	COG0433 Predicted ATPase
MAIC_37280	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_37330	COG2271	Major facilitator Superfamily
MAIC_37380	COG0640	Transcriptional regulator
MAIC_37390	COG0346	lactoylglutathione lyase activity
MAIC_37400	COG0736	holo-[acyl-carrier-protein] synthase activity
MAIC_37420	COG3757	hydrolase, family 25
MAIC_37430	COG3842	ATPase activity
MAIC_37440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MAIC_37450	COG1176	ABC-type spermidine putrescine transport system, permease component I
MAIC_37460	COG1177	transmembrane transport
MAIC_37490	COG1960	acyl-CoA dehydrogenase activity
MAIC_37560	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_37610	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_37640	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_37670	COG1309	transcriptional regulator
MAIC_37680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_37770	COG0583	DNA-binding transcription factor activity
MAIC_37790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAIC_37800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MAIC_37810	COG1070	Carbohydrate kinase
MAIC_37820	COG2124	cytochrome p450
MAIC_37830	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_37840	COG3383	formate dehydrogenase (NAD+) activity
MAIC_37850	COG2267	carboxylic ester hydrolase activity
MAIC_37910	COG3384	dioxygenase
MAIC_37920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_37930	COG0596	Alpha beta hydrolase
MAIC_37950	COG1053	succinate dehydrogenase
MAIC_37970	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_38060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MAIC_38080	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_38120	COG1024	Enoyl-CoA hydratase
MAIC_38130	COG0183	Belongs to the thiolase family
MAIC_38230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAIC_38280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_38290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_38300	COG0183	Belongs to the thiolase family
MAIC_38320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_38340	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_38380	COG1960	acyl-CoA dehydrogenase activity
MAIC_38390	COG1960	acyl-CoA dehydrogenase activity
MAIC_38500	COG2084	Dehydrogenase
MAIC_38510	COG2124	cytochrome p450
MAIC_38540	COG1309	transcriptional regulator
MAIC_38550	COG1960	acyl-CoA dehydrogenase activity
MAIC_38560	COG0183	Belongs to the thiolase family
MAIC_38610	COG4638	Rieske (2fe-2S)
MAIC_38630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MAIC_38650	COG1960	acyl-CoA dehydrogenase activity
MAIC_38660	COG1960	acyl-CoA dehydrogenase activity
MAIC_38710	COG1960	acyl-CoA dehydrogenase activity
MAIC_38720	COG1960	acyl-CoA dehydrogenase activity
MAIC_38730	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_38750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_38760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_38770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAIC_38780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAIC_38780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MAIC_38800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAIC_38830	COG4221	oxidoreductase activity
MAIC_39000	COG2814	Major facilitator Superfamily
MAIC_39020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MAIC_39030	COG2123	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MAIC_39050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MAIC_39090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MAIC_39100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MAIC_39150	COG0058	SHG alpha-glucan phosphorylase activity
MAIC_39160	COG0366	Alpha amylase catalytic
MAIC_39170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MAIC_39200	COG0183	Belongs to the thiolase family
MAIC_39230	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MAIC_39320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MAIC_39330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MAIC_39340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MAIC_39350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MAIC_39350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAIC_39360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MAIC_39370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAIC_39380	COG0356	it plays a direct role in the translocation of protons across the membrane
MAIC_39400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MAIC_39420	COG2890	protein-(glutamine-N5) methyltransferase activity
MAIC_39450	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_39460	COG1309	transcriptional regulator
MAIC_39500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MAIC_39510	COG0460	homoserine dehydrogenase
MAIC_39520	COG0019	diaminopimelate decarboxylase activity
MAIC_39530	COG0018	arginyl-trna synthetase
MAIC_39590	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_39600	COG3321	synthase
MAIC_39600	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_39600	COG0604	alcohol dehydrogenase
MAIC_39690	COG2755	lipolytic protein G-D-S-L family
MAIC_39690	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MAIC_39700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MAIC_39700	COG2755	lipolytic protein G-D-S-L family
MAIC_39710	COG2755	lipolytic protein G-D-S-L family
MAIC_39710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MAIC_39780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAIC_39780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MAIC_39900	COG0438	transferase activity, transferring glycosyl groups
MAIC_40050	COG3321	synthase
MAIC_40050	COG0604	alcohol dehydrogenase
MAIC_40060	COG2070	2-Nitropropane dioxygenase
MAIC_40060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MAIC_40100	COG0531	amino acid
MAIC_40540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_40570	COG0277	FAD linked oxidase domain protein
MAIC_40580	COG0596	Alpha beta hydrolase
MAIC_40590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MAIC_40750	COG4638	Rieske (2fe-2S)
MAIC_40800	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_40810	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_40860	COG3383	formate dehydrogenase (NAD+) activity
MAIC_41050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_41060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_41110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_41180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MAIC_41190	COG0277	FAD linked oxidase domain protein
MAIC_41240	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_41280	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_41300	COG2814	Major facilitator Superfamily
MAIC_41320	COG0567	Dehydrogenase, E1 component
MAIC_41320	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAIC_41330	COG0745	RESPONSE REGULATOR receiver
MAIC_41340	COG2205	protein histidine kinase activity
MAIC_41420	COG0598	Magnesium transport protein CorA
MAIC_41510	COG2301	Belongs to the HpcH HpaI aldolase family
MAIC_41520	COG2239	Acts as a magnesium transporter
MAIC_41570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAIC_41580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAIC_41590	COG5662	AntiSigma factor
MAIC_41630	COG1309	transcriptional regulator
MAIC_41640	COG1131	(ABC) transporter
MAIC_41650	COG3559	Exporter of polyketide antibiotics
MAIC_41680	COG1309	transcriptional regulator
MAIC_41720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAIC_41730	COG0297	glycogen (starch) synthase activity
MAIC_41750	COG0519	Catalyzes the synthesis of GMP from XMP
MAIC_41770	COG0463	Glycosyl transferase, family 2
MAIC_41800	COG1611	Belongs to the LOG family
MAIC_41830	COG1309	transcriptional regulator
MAIC_41850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAIC_41890	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_41940	COG0506	proline dehydrogenase activity
MAIC_41950	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_41990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MAIC_42030	COG0596	Alpha beta hydrolase
MAIC_42040	COG0596	Alpha beta hydrolase
MAIC_42050	COG3629	intracellular signal transduction
MAIC_42110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAIC_42210	COG2124	cytochrome p450
MAIC_42410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAIC_42410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAIC_42500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MAIC_42590	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAIC_42590	COG0596	Alpha beta hydrolase
MAIC_42890	COG3179	chitinase
MAIC_43140	COG3275	phosphorelay sensor kinase activity
MAIC_43150	COG3279	Response regulator of the LytR AlgR family
MAIC_43170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAIC_43190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAIC_43220	COG3467	pyridoxamine 5'-phosphate
MAIC_43250	COG2188	Transcriptional regulator
MAIC_43310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_43320	COG1024	Enoyl-CoA hydratase
MAIC_43360	COG0702	epimerase
MAIC_43380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MAIC_43390	COG1024	Enoyl-CoA hydratase
MAIC_43450	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_43510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAIC_43520	COG2197	response regulator
MAIC_43600	COG5001	Diguanylate cyclase
MAIC_43620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAIC_43630	COG0798	PFAM Bile acid sodium symporter
MAIC_43650	COG0640	Transcriptional regulator
MAIC_43660	COG0012	GTP binding
MAIC_43700	COG1570	exodeoxyribonuclease VII activity
MAIC_43760	COG3119	arylsulfatase activity
MAIC_43780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MAIC_43820	COG0667	Aldo Keto reductase
MAIC_43970	COG0726	polysaccharide deacetylase
MAIC_43980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MAIC_44000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MAIC_44020	COG0572	uridine kinase
MAIC_44070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAIC_44090	COG3631	Ketosteroid isomerase-related protein
MAIC_44100	COG1331	Highly conserved protein containing a thioredoxin domain
MAIC_44120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAIC_44180	COG1714	RDD family
MAIC_44200	COG0657	acetylesterase activity
MAIC_44210	COG2755	lipolytic protein G-D-S-L family
MAIC_44220	COG0183	Belongs to the thiolase family
MAIC_44380	COG4638	Rieske (2fe-2S)
MAIC_44390	COG1177	transmembrane transport
MAIC_44400	COG1176	ABC-type spermidine putrescine transport system, permease component I
MAIC_44420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MAIC_44430	COG3842	ATPase activity
MAIC_44440	COG1309	transcriptional regulator
MAIC_44480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAIC_44490	COG1960	acyl-CoA dehydrogenase activity
MAIC_44540	COG0183	Belongs to the thiolase family
MAIC_44550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MAIC_44560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MAIC_44570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MAIC_44600	COG0254	rRNA binding
MAIC_44740	COG0765	amino acid transport
MAIC_44750	COG1126	abc transporter atp-binding protein
MAIC_44760	COG5285	phytanoyl-CoA dioxygenase
MAIC_44770	COG1917	Cupin 2, conserved barrel domain protein
MAIC_44800	COG1764	response to oxidative stress
MAIC_44870	COG1017	nitric oxide dioxygenase activity
MAIC_44870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MAIC_44900	COG1335	isochorismatase
MAIC_44920	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_44950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAIC_44990	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_45060	COG4977	sequence-specific DNA binding
MAIC_45090	COG3012	SEC-C Motif Domain Protein
MAIC_45100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_45140	COG0668	transmembrane transport
MAIC_45230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MAIC_45310	COG1301	dicarboxylic acid transport
MAIC_45320	COG3290	protein histidine kinase activity
MAIC_45330	COG4565	transcriptional regulatory protein
MAIC_45350	COG1960	acyl-CoA dehydrogenase activity
MAIC_45410	COG0563	adenylate kinase activity
MAIC_45440	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MAIC_45450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MAIC_45470	COG0616	signal peptide processing
MAIC_45480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_45490	COG0200	Binds to the 23S rRNA
MAIC_45500	COG1841	ribosomal large subunit assembly
MAIC_45510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MAIC_45520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MAIC_45550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MAIC_45570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MAIC_45580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MAIC_45590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MAIC_45630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MAIC_45640	COG0255	Belongs to the universal ribosomal protein uL29 family
MAIC_45650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MAIC_45660	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MAIC_45680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MAIC_45690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MAIC_45710	COG0088	Forms part of the polypeptide exit tunnel
MAIC_45720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MAIC_45730	COG0051	transcription antitermination factor activity, RNA binding
MAIC_45820	COG0477	Major facilitator Superfamily
MAIC_45880	COG0535	radical SAM domain protein
MAIC_45930	COG1522	sequence-specific DNA binding
MAIC_45940	COG1834	amidinotransferase
MAIC_45950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MAIC_45960	COG0531	amino acid
MAIC_45980	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_45990	COG2235	arginine
MAIC_46020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MAIC_46030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MAIC_46110	COG1960	acyl-CoA dehydrogenase activity
MAIC_46140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MAIC_46160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAIC_46170	COG0085	RNA polymerase activity
MAIC_46220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MAIC_46230	COG1940	carbohydrate kinase activity
MAIC_46300	COG2318	DinB family
MAIC_46340	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_46350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_46390	COG0489	protein tyrosine kinase activity
MAIC_46470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MAIC_46480	COG2942	2-epimerase
MAIC_46500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MAIC_46500	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MAIC_46540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAIC_46550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MAIC_46590	COG0081	regulation of translation
MAIC_46620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MAIC_46640	COG2030	dehydratase
MAIC_46650	COG2030	dehydratase
MAIC_46660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MAIC_46690	COG0739	heme binding
MAIC_46710	COG1024	Enoyl-CoA hydratase
MAIC_46770	COG2186	Transcriptional regulator
MAIC_46820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MAIC_46870	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_46880	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_46900	COG2813	Specifically methylates the guanine in position
MAIC_46910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_46920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_46940	COG0513	Belongs to the DEAD box helicase family
MAIC_46950	COG1278	Cold shock
MAIC_46990	COG1305	Transglutaminase-like
MAIC_47050	COG0477	Major facilitator Superfamily
MAIC_47130	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_47190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_47280	COG1309	transcriptional regulator
MAIC_47380	COG1487	ribonuclease activity
MAIC_47500	COG1715	Restriction endonuclease
MAIC_47540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MAIC_47570	COG0210	DNA helicase
MAIC_47580	COG1061	Type III restriction enzyme res subunit
MAIC_47670	COG0477	Major facilitator Superfamily
MAIC_47750	COG0596	Alpha beta hydrolase
MAIC_47760	COG2208	phosphoserine phosphatase activity
MAIC_47760	COG2770	Histidine kinase
MAIC_47790	COG4585	Histidine kinase
MAIC_47810	COG1309	transcriptional regulator
MAIC_47820	COG1132	(ABC) transporter
MAIC_47840	COG1666	GTP binding
MAIC_47850	COG2072	flavoprotein involved in K transport
MAIC_47880	COG0501	Belongs to the peptidase M48B family
MAIC_47900	COG0644	oxidoreductase
MAIC_47930	COG2226	methyltransferase
MAIC_47940	COG0300	oxidoreductase activity
MAIC_47950	COG0438	transferase activity, transferring glycosyl groups
MAIC_47980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MAIC_48010	COG4977	sequence-specific DNA binding
MAIC_48060	COG1309	transcriptional regulator
MAIC_48070	COG4948	Mandelate Racemase Muconate Lactonizing
MAIC_48110	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_48130	COG1011	Hydrolase
MAIC_48160	COG4221	oxidoreductase activity
MAIC_48300	COG0745	RESPONSE REGULATOR receiver
MAIC_48310	COG2205	protein histidine kinase activity
MAIC_48330	COG2070	2-Nitropropane dioxygenase
MAIC_48340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAIC_48350	COG0450	alkyl hydroperoxide reductase
MAIC_48360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAIC_48370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MAIC_48390	COG3391	amine dehydrogenase activity
MAIC_48440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MAIC_48460	COG0785	Cytochrome C biogenesis protein
MAIC_48480	COG0406	alpha-ribazole phosphatase activity
MAIC_48550	COG0723	plastoquinol--plastocyanin reductase activity
MAIC_48730	COG2030	dehydratase
MAIC_48840	COG0745	RESPONSE REGULATOR receiver
MAIC_48850	COG5002	protein histidine kinase activity
MAIC_48880	COG0438	transferase activity, transferring glycosyl groups
MAIC_48930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MAIC_48990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MAIC_49040	COG2733	membrane
MAIC_49080	COG2326	polyphosphate kinase activity
MAIC_49090	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MAIC_49240	COG1063	alcohol dehydrogenase
MAIC_49250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_49270	COG1505	serine-type exopeptidase activity
MAIC_49320	COG2326	polyphosphate kinase activity
MAIC_49360	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MAIC_49420	COG1309	transcriptional regulator
MAIC_49460	COG2124	cytochrome p450
MAIC_49470	COG1819	glycosyl
MAIC_49530	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_49540	COG0574	Belongs to the PEP-utilizing enzyme family
MAIC_49540	COG3848	Pyruvate phosphate dikinase
MAIC_49570	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_49590	COG0688	phosphatidylethanolamine metabolic process
MAIC_49610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAIC_49670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MAIC_49670	COG2111	Na H antiporter
MAIC_49750	COG0583	DNA-binding transcription factor activity
MAIC_49760	COG2318	DinB family
MAIC_49830	COG0242	peptide deformylase activity
MAIC_49860	COG2130	NADP-dependent
MAIC_49890	COG2814	Major facilitator Superfamily
MAIC_49920	COG0351	phosphomethylpyrimidine kinase
MAIC_49940	COG2072	flavoprotein involved in K transport
MAIC_49970	COG2233	PERMEase
MAIC_49990	COG2234	aminopeptidase activity
MAIC_50000	COG0701	Predicted permease
MAIC_50030	COG2022	thiamine diphosphate biosynthetic process
MAIC_50050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAIC_50050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MAIC_50090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAIC_50100	COG0515	serine threonine protein kinase
MAIC_50130	COG0640	Transcriptional regulator
MAIC_50160	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MAIC_50230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAIC_50280	COG1216	Glycosyl transferase, family 2
MAIC_50280	COG0463	Glycosyl transferase, family 2
MAIC_50300	COG0438	transferase activity, transferring glycosyl groups
MAIC_50340	COG0673	inositol 2-dehydrogenase activity
MAIC_50370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_50380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAIC_50400	COG4221	oxidoreductase activity
MAIC_50450	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MAIC_50500	COG2409	Drug exporters of the RND superfamily
MAIC_50510	COG2124	cytochrome p450
MAIC_50540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MAIC_50560	COG1994	Peptidase M50
MAIC_50590	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_50600	COG2267	carboxylic ester hydrolase activity
MAIC_50610	COG1960	acyl-CoA dehydrogenase activity
MAIC_50620	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_50650	COG0183	Belongs to the thiolase family
MAIC_50680	COG5651	PPE family
MAIC_50680	COG3391	amine dehydrogenase activity
MAIC_50700	COG1289	transmembrane transporter activity
MAIC_50740	COG0586	Pfam SNARE associated Golgi protein
MAIC_50840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MAIC_50840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MAIC_50860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAIC_50930	COG0300	oxidoreductase activity
MAIC_50970	COG0542	response to heat
MAIC_51130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAIC_51140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAIC_51150	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAIC_51150	COG0022	dehydrogenase e1 component
MAIC_51160	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAIC_51170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAIC_51190	COG0789	Transcriptional regulator
MAIC_51200	COG0484	heat shock protein binding
MAIC_51210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MAIC_51220	COG0443	Heat shock 70 kDa protein
MAIC_51380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_51480	COG2181	nitrate reductase activity
MAIC_51480	COG0247	lactate metabolic process
MAIC_51520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAIC_51580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAIC_51670	COG4399	Belongs to the UPF0754 family
MAIC_51790	COG0747	negative chemotaxis
MAIC_51800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MAIC_51810	COG0601	transmembrane transport
MAIC_51820	COG0444	Belongs to the ABC transporter superfamily
MAIC_51830	COG4608	Belongs to the ABC transporter superfamily
MAIC_51850	COG0028	Belongs to the TPP enzyme family
MAIC_51880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MAIC_51930	COG0655	NAD(P)H dehydrogenase (quinone) activity
MAIC_52000	COG1597	lipid kinase activity
MAIC_52010	COG0671	phosphoesterase, PA-phosphatase related
MAIC_52030	COG4424	Sulfotransferase
MAIC_52050	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_52110	COG0346	lactoylglutathione lyase activity
MAIC_52130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAIC_52150	COG1960	acyl-CoA dehydrogenase activity
MAIC_52170	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_52220	COG1404	Belongs to the peptidase S8 family
MAIC_52350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAIC_52360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAIC_52370	COG1021	2,3-dihydroxybenzoate-AMP ligase
MAIC_52380	COG1169	isochorismate synthase
MAIC_52400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAIC_52440	COG1396	sequence-specific DNA binding
MAIC_52450	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_52460	COG1960	acyl-CoA dehydrogenase activity
MAIC_52470	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_52500	COG1063	alcohol dehydrogenase
MAIC_52510	COG2213	PTS system mannitol-specific
MAIC_52510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAIC_52520	COG1349	DNA-binding transcription factor activity
MAIC_52550	COG2197	response regulator
MAIC_52560	COG1309	transcriptional regulator
MAIC_52570	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_52580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAIC_52580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAIC_52590	COG0596	Alpha beta hydrolase
MAIC_52600	COG0543	2 iron, 2 sulfur cluster binding
MAIC_52600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MAIC_52620	COG1024	Enoyl-CoA hydratase
MAIC_52630	COG1960	acyl-CoA dehydrogenase activity
MAIC_52640	COG1960	acyl-CoA dehydrogenase activity
MAIC_52650	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_52660	COG3104	oligopeptide transport
MAIC_52680	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_52780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MAIC_52790	COG1984	allophanate hydrolase subunit 2
MAIC_52810	COG1846	Transcriptional regulator
MAIC_52840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MAIC_52870	COG1053	succinate dehydrogenase
MAIC_52900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MAIC_52930	COG5651	PPE family
MAIC_52970	COG1960	acyl-CoA dehydrogenase activity
MAIC_52990	COG0183	Belongs to the thiolase family
MAIC_53000	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_53010	COG2030	dehydratase
MAIC_53030	COG1472	Belongs to the glycosyl hydrolase 3 family
MAIC_53060	COG4981	capsule polysaccharide biosynthetic process
MAIC_53090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MAIC_53120	COG2208	phosphoserine phosphatase activity
MAIC_53120	COG2770	Histidine kinase
MAIC_53230	COG0297	glycogen (starch) synthase activity
MAIC_53240	COG0500	methyltransferase
MAIC_53270	COG1960	acyl-CoA dehydrogenase activity
MAIC_53320	COG1960	acyl-CoA dehydrogenase activity
MAIC_53330	COG1960	acyl-CoA dehydrogenase activity
MAIC_53340	COG1024	Enoyl-CoA hydratase
MAIC_53360	COG0318	PFAM AMP-dependent synthetase and ligase
MAIC_53430	COG1063	alcohol dehydrogenase
MAIC_53460	COG1960	acyl-CoA dehydrogenase activity
MAIC_53470	COG1960	acyl-CoA dehydrogenase activity
MAIC_53500	COG1802	Transcriptional regulator
MAIC_53510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MAIC_53520	COG0402	S-adenosylhomocysteine deaminase activity
MAIC_53530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAIC_53550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MAIC_53560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MAIC_53630	COG2188	Transcriptional regulator
MAIC_53640	COG1024	Enoyl-CoA hydratase
MAIC_53670	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MAIC_53700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MAIC_53720	COG2409	Drug exporters of the RND superfamily
MAIC_53770	COG2205	protein histidine kinase activity
MAIC_53810	COG2409	Drug exporters of the RND superfamily
MAIC_53830	COG1832	CoA-binding protein
MAIC_53860	COG3590	peptidase
MAIC_53870	COG0640	Transcriptional regulator
MAIC_53880	COG2814	Major facilitator Superfamily
MAIC_53900	COG1376	ErfK ybiS ycfS ynhG family protein
MAIC_53910	COG2814	Major facilitator Superfamily
MAIC_53920	COG1937	Protein conserved in bacteria
MAIC_53940	COG0129	dihydroxy-acid dehydratase activity
MAIC_53980	COG1414	Transcriptional regulator
MAIC_53990	COG0243	molybdopterin cofactor binding
MAIC_54100	COG2267	carboxylic ester hydrolase activity
MAIC_54120	COG0039	L-malate dehydrogenase activity
MAIC_54160	COG0640	Transcriptional regulator
MAIC_54210	COG0300	oxidoreductase activity
MAIC_54220	COG3619	membrane
MAIC_54280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MAIC_54330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_54340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MAIC_54380	COG1309	transcriptional regulator
MAIC_54520	COG4585	Histidine kinase
MAIC_54550	COG1960	acyl-CoA dehydrogenase activity
MAIC_54590	COG3665	Urea carboxylase-associated protein
MAIC_54600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MAIC_54610	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MAIC_54640	COG1028	Short-chain dehydrogenase reductase Sdr
MAIC_54650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MAIC_54670	COG1012	belongs to the aldehyde dehydrogenase family
MAIC_54710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MAIC_54720	COG1349	DNA-binding transcription factor activity
MAIC_54730	COG1105	Belongs to the carbohydrate kinase PfkB family
MAIC_54740	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MAIC_54740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MAIC_54740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MAIC_54760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAIC_54780	COG0038	chloride channel
MAIC_54800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MAIC_54810	COG0783	Belongs to the Dps family
MAIC_54900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAIC_54980	COG3467	pyridoxamine 5'-phosphate
MAIC_54990	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MAIC_55040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MAIC_55050	COG2132	Multicopper oxidase
MAIC_55060	COG5002	protein histidine kinase activity
MAIC_55090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAIC_55120	COG1309	transcriptional regulator
MAIC_55130	COG0546	phosphoglycolate phosphatase activity
MAIC_55210	COG1914	H( )-stimulated, divalent metal cation uptake system
MAIC_55230	COG1960	acyl-CoA dehydrogenase activity
MAIC_55280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MAIC_55330	COG1129	ABC transporter
MAIC_55330	COG0842	Transport permease protein
MAIC_55340	COG0842	Transport permease protein
MAIC_55370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MAIC_55380	COG1074	ATP-dependent DNA helicase activity
MAIC_55390	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MAIC_55400	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MAIC_55410	COG3119	arylsulfatase activity
MAIC_55430	COG2130	NADP-dependent
MAIC_55450	COG3842	ATPase activity
MAIC_55520	COG2304	oxidoreductase activity
MAIC_55630	COG3619	membrane
MAIC_55650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_55710	COG0243	molybdopterin cofactor binding
MAIC_55720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MAIC_55800	COG1063	alcohol dehydrogenase
MAIC_55820	COG1309	transcriptional regulator
MAIC_55840	COG3158	transport of potassium into the cell
MAIC_55850	COG0247	lactate metabolic process
MAIC_55860	COG1139	Iron-sulfur cluster binding protein
MAIC_55870	COG1556	Lactate utilization protein
MAIC_55910	COG2226	methyltransferase
MAIC_55940	COG4044	May play a role in the intracellular transport of hydrophobic ligands
MAIC_56060	COG1673	EVE domain
MAIC_56100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MAIC_56130	COG0531	amino acid
MAIC_56140	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MAIC_56150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAIC_56190	COG2203	Gaf domain
MAIC_56190	COG2199	diguanylate cyclase activity
MAIC_56200	COG3706	GGDEF domain
MAIC_56230	COG1716	ATPase activity
MAIC_56240	COG1716	ATPase activity
MAIC_56270	COG0768	penicillin binding
MAIC_56280	COG0515	serine threonine protein kinase
MAIC_56290	COG0515	serine threonine protein kinase
MAIC_56290	COG2815	serine threonine protein kinase
MAIC_56380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAIC_56390	COG0187	DNA topoisomerase II activity
MAIC_56400	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MAIC_56410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MAIC_56420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MAIC_56430	COG0592	DNA-directed DNA polymerase activity
MAIC_56460	COG0594	ribonuclease P activity
MAIC_56470	COG0706	membrane insertase activity
MAIC_56490	COG0357	Ribosomal RNA small subunit methyltransferase G
MAIC_56500	COG1192	Involved in chromosome partitioning
MAIC_56530	COG3409	Peptidoglycan-binding domain 1 protein
MAIC_56530	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAIC_56570	COG1595	DNA-templated transcription, initiation
MAIC_56670	COG1678	Uncharacterized ACR, COG1678
MAIC_56720	COG0300	oxidoreductase activity
MAIC_56750	COG1126	abc transporter atp-binding protein
MAIC_56760	COG0765	amino acid transport
MAIC_56790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAIC_56810	COG1260	myo-inositol-1-phosphate synthase
MAIC_56850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAIC_56880	COG0360	Binds together with S18 to 16S ribosomal RNA
MAIC_56910	COG0359	binds to the 23S rRNA
MAIC_56920	COG0305	Participates in initiation and elongation during chromosome replication
MAIC_57060	COG1309	transcriptional regulator
MAIC_57070	COG1234	tRNA 3'-trailer cleavage
MAIC_57100	COG0644	oxidoreductase
MAIC_57160	COG3848	Pyruvate phosphate dikinase
MAIC_57160	COG0574	Belongs to the PEP-utilizing enzyme family
MAIC_57200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAIC_57210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate