locus-tag	class	description
FRW55_00020	COG0564	pseudouridine synthase activity
FRW55_00030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FRW55_00140	COG0254	rRNA binding
FRW55_00325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FRW55_00435	COG3331	DNA recombination
FRW55_00440	COG0776	regulation of translation
FRW55_00470	COG1187	pseudouridine synthase activity
FRW55_00540	COG0081	regulation of translation
FRW55_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FRW55_00720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FRW55_00770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FRW55_00775	COG0222	ribosome binding
FRW55_00925	COG1307	EDD domain protein, DegV family
FRW55_01005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRW55_01350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FRW55_01425	COG0571	ribonuclease III activity
FRW55_01490	COG0813	purine-nucleoside phosphorylase activity
FRW55_01585	COG0217	transcriptional regulatory protein
FRW55_01590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRW55_01600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FRW55_01625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FRW55_01630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FRW55_01640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRW55_01645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FRW55_01650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FRW55_01710	COG1739	Uncharacterized protein family UPF0029
FRW55_01730	COG0295	cytidine deaminase activity
FRW55_01735	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FRW55_01750	COG0698	ribose 5-phosphate isomerase
FRW55_01835	COG2001	Belongs to the MraZ family
FRW55_01860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRW55_01865	COG0237	dephospho-CoA kinase activity
FRW55_02025	COG2376	Dihydroxyacetone kinase
FRW55_02060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FRW55_02090	COG2190	(PTS) system
FRW55_02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FRW55_02090	COG1263	PTS System
FRW55_02095	COG0194	GDP metabolic process
FRW55_02215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FRW55_02235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRW55_02305	COG0358	DNA primase activity
FRW55_02345	COG1435	thymidine kinase activity
FRW55_02360	COG1122	ATPase activity
FRW55_02390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRW55_02610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FRW55_02640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRW55_02645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRW55_02735	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FRW55_02740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FRW55_02805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRW55_02810	COG0280	phosphate acetyltransferase
FRW55_02890	COG0556	nucleotide-excision repair
FRW55_03045	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FRW55_03050	COG1447	Phosphotransferase system cellobiose-specific component IIA
FRW55_03140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FRW55_03280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FRW55_03530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRW55_03535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRW55_03650	COG0233	cytoplasmic translational termination
FRW55_03665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FRW55_03675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FRW55_03695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FRW55_03750	COG0051	transcription antitermination factor activity, RNA binding
FRW55_03765	COG0089	rRNA binding
FRW55_03805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FRW55_03810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FRW55_03830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FRW55_03835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FRW55_03860	COG0563	adenylate kinase activity
FRW55_03870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FRW55_03875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FRW55_03880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FRW55_03890	COG0202	RNA polymerase activity
FRW55_03900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRW55_04030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRW55_04055	COG0227	Belongs to the bacterial ribosomal protein bL28 family