locus-tag	class	description
HU154_00010	COG0594	ribonuclease P activity
HU154_00015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HU154_00025	COG0592	DNA-directed DNA polymerase activity
HU154_00035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HU154_00060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HU154_00125	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HU154_00150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HU154_00155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HU154_00215	COG3655	Transcriptional regulator
HU154_00235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HU154_00240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HU154_00295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HU154_00315	COG1435	thymidine kinase activity
HU154_00530	COG0081	regulation of translation
HU154_00570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HU154_00575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HU154_00590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HU154_00595	COG0268	Binds directly to 16S ribosomal RNA
HU154_00650	COG0360	Binds together with S18 to 16S ribosomal RNA
HU154_00660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HU154_00735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HU154_00770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HU154_00835	COG1739	Uncharacterized protein family UPF0029
HU154_00840	COG0564	pseudouridine synthase activity
HU154_00860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HU154_00915	COG1187	pseudouridine synthase activity
HU154_00950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HU154_01000	COG0776	regulation of translation
HU154_01095	COG0124	histidyl-tRNA synthetase
HU154_01130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HU154_01155	COG1122	ATPase activity
HU154_01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HU154_01275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HU154_01285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HU154_01295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HU154_01390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HU154_01405	COG2001	Belongs to the MraZ family
HU154_01470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HU154_01485	COG0149	triose-phosphate isomerase activity
HU154_01545	COG0228	four-way junction DNA binding
HU154_01555	COG0335	large ribosomal subunit rRNA binding
HU154_01575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HU154_01580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HU154_01615	COG0222	ribosome binding
HU154_01635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HU154_01655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HU154_01660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HU154_01675	COG0563	adenylate kinase activity
HU154_01685	COG0200	Binds to the 23S rRNA
HU154_01695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HU154_01700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HU154_01725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HU154_01730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HU154_01735	COG0255	Belongs to the universal ribosomal protein uL29 family
HU154_01750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HU154_01765	COG0089	rRNA binding
HU154_01780	COG0051	transcription antitermination factor activity, RNA binding
HU154_01795	COG0254	rRNA binding
HU154_01980	COG0813	purine-nucleoside phosphorylase activity
HU154_02010	COG0492	ferredoxin-NADP+ reductase activity
HU154_02095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HU154_02170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HU154_02270	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HU154_02320	COG1214	PFAM Peptidase M22, glycoprotease
HU154_02355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HU154_02400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HU154_02435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HU154_02435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HU154_02475	COG0193	aminoacyl-tRNA hydrolase activity
HU154_02545	COG1131	(ABC) transporter
HU154_02575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HU154_02640	COG1323	Belongs to the UPF0348 family
HU154_02680	COG0233	cytoplasmic translational termination
HU154_02700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HU154_02745	COG0556	nucleotide-excision repair
HU154_02775	COG0194	GDP metabolic process
HU154_02790	COG1162	GTPase activity
HU154_02865	COG1481	regulation of sporulation
HU154_02990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA