locus-tag	class	description
A6J44_00015	COG0629	single-stranded DNA binding
A6J44_00095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J44_00200	COG2948	multi-organism process
A6J44_00210	COG3504	Conjugal transfer protein
A6J44_00215	COG3701	Conjugal transfer protein
A6J44_00220	COG3451	type IV secretory pathway VirB4
A6J44_00230	COG3838	Conjugal transfer protein Trbc
A6J44_00325	COG2814	Major facilitator Superfamily
A6J44_00360	COG1137	ATPase activity
A6J44_00365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6J44_00375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6J44_00525	COG1802	Transcriptional regulator
A6J44_00525	COG4626	Terminase
A6J44_00530	COG1484	DNA-dependent DNA replication
A6J44_00655	COG0569	domain protein
A6J44_00680	COG3676	manually curated
A6J44_00695	COG0351	phosphomethylpyrimidine kinase
A6J44_00845	COG3676	manually curated
A6J44_00850	COG0347	Belongs to the P(II) protein family
A6J44_00865	COG0640	Transcriptional regulator
A6J44_00875	COG2239	Acts as a magnesium transporter
A6J44_00890	COG0791	NLP P60 protein
A6J44_00905	COG1380	Effector of murein hydrolase LrgA
A6J44_00910	COG1346	cytolysis
A6J44_00920	COG0038	chloride channel
A6J44_00925	COG1643	Atp-dependent helicase
A6J44_00940	COG1643	Atp-dependent helicase
A6J44_01010	COG3617	BRO family, N-terminal domain
A6J44_01040	COG2350	Protein conserved in bacteria
A6J44_01065	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6J44_01080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J44_01140	COG0142	geranyltranstransferase activity
A6J44_01195	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6J44_01205	COG0739	heme binding
A6J44_01255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J44_01325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J44_01350	COG2259	Doxx family
A6J44_01355	COG0583	DNA-binding transcription factor activity
A6J44_01360	COG0415	Belongs to the DNA photolyase family
A6J44_01365	COG1199	ATP-dependent helicase activity
A6J44_01375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J44_01395	COG0557	exoribonuclease II activity
A6J44_01405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J44_01420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J44_01440	COG0514	ATP-dependent DNA helicase (RecQ)
A6J44_01450	COG2226	methyltransferase
A6J44_01460	COG1040	competence protein
A6J44_01465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J44_01490	COG1132	(ABC) transporter
A6J44_01505	COG0142	geranyltranstransferase activity
A6J44_01565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A6J44_01570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A6J44_01590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J44_01610	COG3676	manually curated
A6J44_01740	COG1546	Belongs to the CinA family
A6J44_01765	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J44_01880	COG3842	ATPase activity
A6J44_01885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J44_01905	COG1793	dna ligase
A6J44_01910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J44_01920	COG2857	Cytochrome c1
A6J44_01925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J44_01930	COG0723	plastoquinol--plastocyanin reductase activity
A6J44_01940	COG0583	DNA-binding transcription factor activity
A6J44_01990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J44_02010	COG2056	Na+-H+ antiporter family
A6J44_02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J44_02025	COG1126	abc transporter atp-binding protein
A6J44_02035	COG0765	amino acid transport
A6J44_02040	COG0312	modulator of DNA gyrase
A6J44_02100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J44_02150	COG0708	Exodeoxyribonuclease III
A6J44_02180	COG3038	cytochrome b561
A6J44_02210	COG0024	Methionine aminopeptidase
A6J44_02340	COG0616	signal peptide processing
A6J44_02340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J44_02345	COG1546	Belongs to the CinA family
A6J44_02345	COG1058	Belongs to the CinA family
A6J44_02390	COG0729	surface antigen
A6J44_02400	COG3104	oligopeptide transport
A6J44_02425	COG2259	Doxx family
A6J44_02440	COG3219	Protein conserved in bacteria
A6J44_02445	COG1595	DNA-templated transcription, initiation
A6J44_02485	COG1739	Uncharacterized protein family UPF0029
A6J44_02500	COG0859	PFAM glycosyl transferase family 9
A6J44_02505	COG1335	isochorismatase
A6J44_02555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J44_02565	COG2884	Cell division ATP-binding protein ftsE
A6J44_02595	COG0861	Integral membrane protein TerC family
A6J44_02605	COG1519	Transferase
A6J44_02610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J44_02645	COG1289	transmembrane transporter activity
A6J44_02670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J44_02675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J44_02735	COG1297	OPT oligopeptide transporter protein
A6J44_02785	COG0786	glutamate:sodium symporter activity
A6J44_02815	COG0469	pyruvate kinase activity
A6J44_02905	COG1652	LysM domain
A6J44_02935	COG5000	phosphorelay sensor kinase activity
A6J44_02940	COG2204	response regulator
A6J44_02945	COG0758	DNA mediated transformation
A6J44_02980	COG0742	ribosomal rna small subunit methyltransferase
A6J44_02985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J44_03015	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J44_03215	COG0201	protein transport
A6J44_03225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J44_03325	COG1115	amino acid carrier protein
A6J44_03420	COG1192	Involved in chromosome partitioning
A6J44_03445	COG1115	amino acid carrier protein
A6J44_03455	COG1530	ribonuclease E activity
A6J44_03465	COG0564	pseudouridine synthase activity
A6J44_03505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J44_03515	COG2878	Part of a membrane complex involved in electron transport
A6J44_03555	COG1760	l-serine dehydratase
A6J44_03575	COG0339	signal peptide processing
A6J44_03580	COG1858	cytochrome C peroxidase
A6J44_03595	COG0753	catalase activity
A6J44_03625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J44_03660	COG0210	DNA helicase
A6J44_03695	COG1368	sulfuric ester hydrolase activity
A6J44_03705	COG0814	amino acid
A6J44_03725	COG3265	gluconokinase activity
A6J44_03745	COG0288	reversible hydration of carbon dioxide
A6J44_03755	COG0799	negative regulation of ribosome biogenesis
A6J44_03790	COG4604	ABC transporter, ATP-binding protein
A6J44_03805	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J44_03850	COG0733	neurotransmitter:sodium symporter activity
A6J44_03880	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
A6J44_03955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J44_03955	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J44_03965	COG1012	belongs to the aldehyde dehydrogenase family
A6J44_03980	COG1127	ABC transporter
A6J44_03985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J44_03990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J44_03995	COG2854	intermembrane phospholipid transfer
A6J44_04015	COG0824	Thioesterase
A6J44_04050	COG0625	glutathione transferase activity
A6J44_04055	COG2969	positive regulation of protein catabolic process
A6J44_04065	COG1610	YqeY-like protein
A6J44_04085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J44_04090	COG2011	ABC-type metal ion transport system permease component
A6J44_04095	COG1464	Belongs to the NlpA lipoprotein family
A6J44_04130	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J44_04180	COG1216	Glycosyl transferase, family 2
A6J44_04205	COG1216	Glycosyl transferase, family 2
A6J44_04230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J44_04235	COG0483	inositol monophosphate 1-phosphatase activity
A6J44_04250	COG1028	Short-chain dehydrogenase reductase Sdr
A6J44_04265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J44_04315	COG1399	metal-binding, possibly nucleic acid-binding protein
A6J44_04465	COG1956	GAF domain-containing protein
A6J44_04470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J44_04475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J44_04500	COG1505	serine-type exopeptidase activity
A6J44_04530	COG1214	PFAM Peptidase M22, glycoprotease
A6J44_04590	COG0439	Biotin carboxylase
A6J44_04595	COG0511	ligase activity, forming carbon-carbon bonds
A6J44_04635	COG2852	Protein conserved in bacteria
A6J44_04725	COG0489	protein tyrosine kinase activity
A6J44_04735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J44_04765	COG0012	GTP binding
A6J44_04820	COG0196	riboflavin kinase activity
A6J44_04940	COG0613	PHP domain protein
A6J44_04945	COG3977	Valine--pyruvate aminotransferase
A6J44_04955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J44_04960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J44_04980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J44_04980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J44_04990	COG0121	glutamine amidotransferase
A6J44_05070	COG1333	cytochrome c biogenesis protein
A6J44_05075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J44_05100	COG0431	NADPH-dependent FMN reductase
A6J44_05110	COG2851	Citrate transporter
A6J44_05115	COG0745	RESPONSE REGULATOR receiver
A6J44_05125	COG1530	ribonuclease E activity
A6J44_05140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J44_05220	COG0720	synthase
A6J44_05225	COG3759	membrane
A6J44_05245	COG1757	Na H antiporter
A6J44_05255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J44_05260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J44_05285	COG4535	Mg2 and Co2 transporter CorC
A6J44_05325	COG0513	Belongs to the DEAD box helicase family
A6J44_05335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J44_05350	COG1560	Kdo2-lipid A biosynthetic process
A6J44_05365	COG0308	aminopeptidase N
A6J44_05370	COG3676	manually curated
A6J44_05415	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J44_05420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J44_05460	COG2205	protein histidine kinase activity
A6J44_05465	COG0745	RESPONSE REGULATOR receiver
A6J44_05485	COG0805	protein transport
A6J44_05510	COG1063	alcohol dehydrogenase
A6J44_05605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J44_05615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J44_05640	COG0616	signal peptide processing
A6J44_05655	COG2084	Dehydrogenase
A6J44_05685	COG1999	signal sequence binding
A6J44_05695	COG0028	Belongs to the TPP enzyme family
A6J44_05720	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6J44_05750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J44_05760	COG1765	OsmC-like protein
A6J44_05770	COG1802	Transcriptional regulator
A6J44_05775	COG2431	L-lysine efflux transmembrane transporter activity
A6J44_05780	COG1349	DNA-binding transcription factor activity
A6J44_05810	COG0318	PFAM AMP-dependent synthetase and ligase
A6J44_05865	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J44_05885	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6J44_05890	COG1862	Preprotein translocase
A6J44_05895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J44_05900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J44_05910	COG3842	ATPase activity
A6J44_05920	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J44_05925	COG1177	transmembrane transport
A6J44_05930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J44_05935	COG0004	ammonium transporteR
A6J44_05960	COG3676	manually curated
A6J44_05975	COG2833	Protein of unknown function (DUF455)
A6J44_06005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J44_06040	COG1178	ABC-type Fe3 transport system permease component
A6J44_06085	COG0494	nUDIX hydrolase
A6J44_06155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J44_06170	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6J44_06175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J44_06185	COG0280	phosphate acetyltransferase
A6J44_06185	COG0281	malic enzyme
A6J44_06240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J44_06335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J44_06350	COG0285	dihydrofolate synthase activity
A6J44_06365	COG1126	abc transporter atp-binding protein
A6J44_06435	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6J44_06440	COG1466	dna polymerase III delta subunit
A6J44_06455	COG1561	YicC-like family, N-terminal region
A6J44_06585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J44_06585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J44_06595	COG3161	chorismate lyase activity
A6J44_06625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J44_06630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6J44_06635	COG0497	DNA recombination
A6J44_06655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J44_06655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J44_06675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J44_06700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J44_06780	COG0681	Belongs to the peptidase S26 family
A6J44_06790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J44_06810	COG0084	hydrolase, TatD family'
A6J44_06820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6J44_06930	COG1074	ATP-dependent DNA helicase activity
A6J44_06935	COG2837	iron assimilation
A6J44_06945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J44_06950	COG0765	amino acid transport
A6J44_06955	COG1126	abc transporter atp-binding protein
A6J44_06965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J44_06970	COG0471	metal ion transport
A6J44_06995	COG2867	negative regulation of translational initiation
A6J44_07000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J44_07020	COG0626	cystathionine gamma-synthase activity
A6J44_07035	COG1187	pseudouridine synthase activity
A6J44_07050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J44_07055	COG1309	transcriptional regulator
A6J44_07110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J44_07110	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6J44_07125	COG3645	SOS response
A6J44_07145	COG0542	response to heat
A6J44_07155	COG1278	Cold shock
A6J44_07160	COG0312	modulator of DNA gyrase
A6J44_07195	COG1702	phosphate starvation-inducible protein PhoH
A6J44_07200	COG0438	transferase activity, transferring glycosyl groups
A6J44_07355	COG1686	Belongs to the peptidase S11 family
A6J44_07360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J44_07375	COG4208	sulfate ABC transporter
A6J44_07390	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6J44_07400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J44_07410	COG0305	Participates in initiation and elongation during chromosome replication
A6J44_07455	COG0436	Aminotransferase
A6J44_07475	COG0582	viral genome integration into host DNA
A6J44_07595	COG0305	Participates in initiation and elongation during chromosome replication
A6J44_07710	COG3617	BRO family, N-terminal domain
A6J44_07750	COG4221	oxidoreductase activity
A6J44_07755	COG1607	acyl-coa hydrolase
A6J44_07795	COG3676	manually curated
A6J44_07880	COG3676	manually curated
A6J44_07890	COG1966	Carbon starvation protein
A6J44_07910	COG1012	belongs to the aldehyde dehydrogenase family
A6J44_07920	COG1253	flavin adenine dinucleotide binding
A6J44_07935	COG1607	acyl-coa hydrolase
A6J44_07975	COG1942	4-Oxalocrotonate Tautomerase
A6J44_07980	COG0436	Aminotransferase
A6J44_08010	COG0248	Ppx GppA phosphatase
A6J44_08065	COG2814	Major facilitator Superfamily
A6J44_08080	COG0697	spore germination
A6J44_08100	COG0348	domain, Protein
A6J44_08110	COG2070	2-Nitropropane dioxygenase
A6J44_08180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J44_08270	COG3945	hemerythrin HHE cation binding domain
A6J44_08305	COG0859	PFAM glycosyl transferase family 9
A6J44_08330	COG0277	FAD linked oxidase domain protein
A6J44_08350	COG1562	ergosterol biosynthetic process
A6J44_08390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J44_08420	COG0765	amino acid transport
A6J44_08450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6J44_08460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J44_08470	COG0589	response to stress
A6J44_08555	COG0590	tRNA wobble adenosine to inosine editing
A6J44_08595	COG2813	Specifically methylates the guanine in position
A6J44_08595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6J44_08635	COG0678	peroxiredoxin activity
A6J44_08635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J44_08665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J44_08680	COG0567	Dehydrogenase, E1 component
A6J44_08685	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J44_08690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J44_08720	COG2963	transposase activity
A6J44_08725	COG2801	Transposase and inactivated derivatives
A6J44_08740	COG1139	Iron-sulfur cluster binding protein
A6J44_08750	COG0247	lactate metabolic process
A6J44_08755	COG0477	Major facilitator Superfamily
A6J44_08760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J44_08765	COG0791	NLP P60 protein
A6J44_08820	COG0277	FAD linked oxidase domain protein
A6J44_08840	COG1773	rubredoxin
A6J44_08855	COG2963	transposase activity
A6J44_08860	COG2801	Transposase and inactivated derivatives
A6J44_08885	COG4150	thiosulfate binding
A6J44_08895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J44_08925	COG0586	Pfam SNARE associated Golgi protein
A6J44_08940	COG1476	TRANSCRIPTIONal
A6J44_08965	COG2841	Protein conserved in bacteria
A6J44_08985	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6J44_09055	COG3012	SEC-C Motif Domain Protein
A6J44_09055	COG3318	Belongs to the UPF0149 family
A6J44_09065	COG2866	Carboxypeptidase
A6J44_09090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J44_09120	COG0300	oxidoreductase activity
A6J44_09125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A6J44_09130	COG1562	ergosterol biosynthetic process
A6J44_09170	COG2975	iron-sulfur cluster assembly
A6J44_09175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J44_09190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J44_09210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J44_09285	COG0557	exoribonuclease II activity
A6J44_09340	COG0628	permease
A6J44_09370	COG1192	Involved in chromosome partitioning
A6J44_09410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J44_09455	COG4453	Protein conserved in bacteria
A6J44_09715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J44_09735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J44_09770	COG1393	Belongs to the ArsC family
A6J44_09775	COG0488	(ABC) transporter
A6J44_09820	COG3850	Histidine kinase
A6J44_09825	COG2197	response regulator
A6J44_09860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J44_09885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J44_09920	COG0210	DNA helicase
A6J44_09965	COG3676	manually curated
A6J44_10015	COG3093	addiction module antidote protein HigA
A6J44_10080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J44_10090	COG0800	Aldolase
A6J44_10105	COG1194	a g-specific adenine glycosylase
A6J44_10190	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6J44_10195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J44_10265	COG2217	Heavy metal translocating P-type atpase
A6J44_10270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J44_10280	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J44_10345	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6J44_10355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J44_10355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J44_10370	COG1012	belongs to the aldehyde dehydrogenase family
A6J44_10375	COG2095	MarC family integral membrane protein
A6J44_10390	COG2990	Protein conserved in bacteria
A6J44_10400	COG0543	2 iron, 2 sulfur cluster binding
A6J44_10400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J44_10435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J44_10465	COG0513	Belongs to the DEAD box helicase family
A6J44_10520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6J44_10525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6J44_10530	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A6J44_10535	COG3421	Type III restriction
A6J44_10540	COG1304	FMN binding
A6J44_10570	COG0822	iron-sulfur transferase activity
A6J44_10575	COG0316	Belongs to the HesB IscA family
A6J44_10580	COG3036	rescue of stalled ribosome
A6J44_10595	COG3676	manually curated
A6J44_10610	COG2951	lytic endotransglycosylase activity
A6J44_10625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J44_10660	COG0633	Ferredoxin
A6J44_10665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J44_10670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J44_10700	COG0741	lytic transglycosylase activity
A6J44_10700	COG1388	LysM domain
A6J44_10710	COG0733	neurotransmitter:sodium symporter activity
A6J44_10730	COG0789	Transcriptional regulator
A6J44_10740	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6J44_10745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6J44_10815	COG1183	phosphatidylcholine synthase activity
A6J44_10820	COG0730	response to heat
A6J44_10850	COG0492	ferredoxin-NADP+ reductase activity
A6J44_10855	COG2217	Heavy metal translocating P-type atpase
A6J44_10895	COG0793	Belongs to the peptidase S41A family
A6J44_10905	COG3045	CreA protein
A6J44_10920	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J44_10930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6J44_10935	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J44_10945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J44_10970	COG3676	manually curated
A6J44_10985	COG1027	Aspartate ammonia-lyase
A6J44_11005	COG0697	spore germination
A6J44_11020	COG0251	oxidation-reduction process
A6J44_11045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J44_11050	COG0523	cobalamin synthesis protein
A6J44_11060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J44_11105	COG2814	Major facilitator Superfamily
A6J44_11125	COG0318	PFAM AMP-dependent synthetase and ligase
A6J44_11130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J44_11305	COG5410	chromosome segregation
A6J44_11355	COG0305	Participates in initiation and elongation during chromosome replication
A6J44_11530	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J44_11545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A6J44_11560	COG0778	Nitroreductase
A6J44_11565	COG2194	sulfuric ester hydrolase activity
A6J44_11595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J44_11605	COG1272	protein, Hemolysin III
A6J44_11610	COG1115	amino acid carrier protein
A6J44_11680	COG3676	manually curated
A6J44_11740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J44_11745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J44_11765	COG0561	phosphatase activity
A6J44_11795	COG3676	manually curated
A6J44_11805	COG2995	paraquat-inducible protein a
A6J44_11810	COG3008	intermembrane lipid transfer
A6J44_11810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J44_11820	COG0519	Catalyzes the synthesis of GMP from XMP
A6J44_11865	COG3245	cytochrome
A6J44_11875	COG1448	Aminotransferase
A6J44_11895	COG0187	DNA topoisomerase II activity
A6J44_11910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J44_11925	COG0252	asparaginase activity
A6J44_11930	COG0586	Pfam SNARE associated Golgi protein
A6J44_11945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J44_12010	COG0733	neurotransmitter:sodium symporter activity
A6J44_12025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J44_12035	COG2186	Transcriptional regulator
A6J44_12040	COG1620	l-lactate permease
A6J44_12050	COG1538	Outer membrane efflux protein
A6J44_12080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J44_12085	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6J44_12100	COG2010	Cytochrome c
A6J44_12115	COG3278	Belongs to the heme-copper respiratory oxidase family
A6J44_12125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J44_12125	COG3453	Protein conserved in bacteria
A6J44_12145	COG1994	Peptidase M50
A6J44_12150	COG2999	glutathione oxidoreductase activity
A6J44_12160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J44_12275	COG0644	oxidoreductase
A6J44_12275	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A6J44_12285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A6J44_12310	COG3901	Regulator of nitric oxide reductase transcription
A6J44_12310	COG0348	domain, Protein
A6J44_12350	COG1522	sequence-specific DNA binding
A6J44_12360	COG2832	Protein of unknown function (DUF454)
A6J44_12375	COG3676	manually curated
A6J44_12410	COG1477	protein flavinylation
A6J44_12415	COG2991	Protein conserved in bacteria
A6J44_12425	COG1045	serine acetyltransferase
A6J44_12485	COG1116	anion transmembrane transporter activity
A6J44_12500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J44_12505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J44_12515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J44_12525	COG1196	nuclear chromosome segregation
A6J44_12550	COG1620	l-lactate permease
A6J44_12565	COG1448	Aminotransferase
A6J44_12645	COG0560	Phosphoserine phosphatase
A6J44_12655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6J44_12665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J44_12670	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J44_12680	COG0583	DNA-binding transcription factor activity
A6J44_12720	COG0500	methyltransferase
A6J44_12725	COG2830	Protein of unknown function (DUF452)
A6J44_12735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J44_12740	COG1376	ErfK ybiS ycfS ynhG family protein
A6J44_12745	COG0471	metal ion transport
A6J44_12875	COG0802	atpase or kinase
A6J44_12925	COG2814	Major facilitator Superfamily
A6J44_12935	COG0697	spore germination
A6J44_12950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J44_12955	COG0287	Prephenate dehydrogenase
A6J44_12975	COG1959	2 iron, 2 sulfur cluster binding
A6J44_12980	COG0009	L-threonylcarbamoyladenylate synthase
A6J44_13025	COG0372	Belongs to the citrate synthase family
A6J44_13035	COG2252	PERMEase
A6J44_13110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J44_13115	COG2194	sulfuric ester hydrolase activity
A6J44_13180	COG2960	long-chain fatty acid transporting porin activity
A6J44_13235	COG0708	Exodeoxyribonuclease III
A6J44_13285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J44_13320	COG0488	(ABC) transporter
A6J44_13325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J44_13330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J44_13355	COG0583	DNA-binding transcription factor activity
A6J44_13360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J44_13365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J44_13440	COG0564	pseudouridine synthase activity
A6J44_13445	COG0561	phosphatase activity
A6J44_13675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6J44_13940	COG2801	Transposase and inactivated derivatives
A6J44_13945	COG2801	Transposase and inactivated derivatives