locus-tag	class	description
EGH14_00055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EGH14_00115	COG1956	GAF domain-containing protein
EGH14_00120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EGH14_00125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGH14_00160	COG1505	serine-type exopeptidase activity
EGH14_00190	COG1214	PFAM Peptidase M22, glycoprotease
EGH14_00255	COG0439	Biotin carboxylase
EGH14_00260	COG0511	ligase activity, forming carbon-carbon bonds
EGH14_00290	COG2852	Protein conserved in bacteria
EGH14_00345	COG0489	protein tyrosine kinase activity
EGH14_00355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGH14_00390	COG0012	GTP binding
EGH14_00440	COG0196	riboflavin kinase activity
EGH14_00560	COG0613	PHP domain protein
EGH14_00565	COG3977	Valine--pyruvate aminotransferase
EGH14_00575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EGH14_00580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGH14_00600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGH14_00600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGH14_00610	COG0121	glutamine amidotransferase
EGH14_00700	COG1333	cytochrome c biogenesis protein
EGH14_00705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGH14_00735	COG0431	NADPH-dependent FMN reductase
EGH14_00750	COG2851	Citrate transporter
EGH14_00755	COG0745	RESPONSE REGULATOR receiver
EGH14_00765	COG1530	ribonuclease E activity
EGH14_00780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EGH14_00865	COG0720	synthase
EGH14_00875	COG3759	membrane
EGH14_00895	COG1757	Na H antiporter
EGH14_00905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGH14_00910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGH14_00935	COG4535	Mg2 and Co2 transporter CorC
EGH14_00985	COG0513	Belongs to the DEAD box helicase family
EGH14_00995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGH14_01010	COG1560	Kdo2-lipid A biosynthetic process
EGH14_01025	COG0308	aminopeptidase N
EGH14_01030	COG3676	manually curated
EGH14_01080	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGH14_01085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGH14_01120	COG2205	protein histidine kinase activity
EGH14_01125	COG0745	RESPONSE REGULATOR receiver
EGH14_01145	COG0805	protein transport
EGH14_01170	COG1063	alcohol dehydrogenase
EGH14_01180	COG0123	including yeast histone deacetylase and acetoin utilization protein
EGH14_01185	COG1862	Preprotein translocase
EGH14_01190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGH14_01195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGH14_01205	COG3842	ATPase activity
EGH14_01220	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGH14_01225	COG1177	transmembrane transport
EGH14_01235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGH14_01240	COG0004	ammonium transporteR
EGH14_01265	COG3676	manually curated
EGH14_01280	COG2833	Protein of unknown function (DUF455)
EGH14_01305	COG1216	Glycosyl transferase, family 2
EGH14_01310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGH14_01355	COG1178	ABC-type Fe3 transport system permease component
EGH14_01400	COG0494	nUDIX hydrolase
EGH14_01475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGH14_01490	COG3023	N-Acetylmuramoyl-L-alanine amidase
EGH14_01495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGH14_01505	COG0280	phosphate acetyltransferase
EGH14_01505	COG0281	malic enzyme
EGH14_01560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGH14_01645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EGH14_01660	COG0285	dihydrofolate synthase activity
EGH14_01675	COG1126	abc transporter atp-binding protein
EGH14_01745	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EGH14_01750	COG1466	dna polymerase III delta subunit
EGH14_01765	COG1561	YicC-like family, N-terminal region
EGH14_01895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGH14_01895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGH14_01905	COG3161	chorismate lyase activity
EGH14_01940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EGH14_01945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGH14_01950	COG0497	DNA recombination
EGH14_01975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGH14_01975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EGH14_01995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EGH14_02025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGH14_02105	COG0681	Belongs to the peptidase S26 family
EGH14_02115	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGH14_02135	COG0084	hydrolase, TatD family'
EGH14_02145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EGH14_02255	COG1074	ATP-dependent DNA helicase activity
EGH14_02260	COG2837	iron assimilation
EGH14_02270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGH14_02275	COG0765	amino acid transport
EGH14_02280	COG1126	abc transporter atp-binding protein
EGH14_02290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGH14_02295	COG0471	metal ion transport
EGH14_02325	COG2867	negative regulation of translational initiation
EGH14_02330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGH14_02350	COG0626	cystathionine gamma-synthase activity
EGH14_02360	COG0778	Nitroreductase
EGH14_02365	COG1187	pseudouridine synthase activity
EGH14_02380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGH14_02385	COG1309	transcriptional regulator
EGH14_02440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGH14_02440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGH14_02455	COG3645	SOS response
EGH14_02475	COG0542	response to heat
EGH14_02485	COG1278	Cold shock
EGH14_02490	COG0312	modulator of DNA gyrase
EGH14_02525	COG1702	phosphate starvation-inducible protein PhoH
EGH14_02530	COG0438	transferase activity, transferring glycosyl groups
EGH14_02620	COG0564	pseudouridine synthase activity
EGH14_02685	COG1686	Belongs to the peptidase S11 family
EGH14_02690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGH14_02700	COG4208	sulfate ABC transporter
EGH14_02715	COG1755	Isoprenylcysteine carboxyl methyltransferase
EGH14_02725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGH14_02735	COG0305	Participates in initiation and elongation during chromosome replication
EGH14_02785	COG0436	Aminotransferase
EGH14_02805	COG0582	viral genome integration into host DNA
EGH14_02915	COG0305	Participates in initiation and elongation during chromosome replication
EGH14_03025	COG3617	BRO family, N-terminal domain
EGH14_03065	COG4221	oxidoreductase activity
EGH14_03070	COG1607	acyl-coa hydrolase
EGH14_03100	COG3676	manually curated
EGH14_03185	COG3676	manually curated
EGH14_03195	COG1966	Carbon starvation protein
EGH14_03215	COG1012	belongs to the aldehyde dehydrogenase family
EGH14_03230	COG1253	flavin adenine dinucleotide binding
EGH14_03245	COG1607	acyl-coa hydrolase
EGH14_03285	COG1942	4-Oxalocrotonate Tautomerase
EGH14_03290	COG0436	Aminotransferase
EGH14_03320	COG0248	Ppx GppA phosphatase
EGH14_03360	COG2814	Major facilitator Superfamily
EGH14_03375	COG0697	spore germination
EGH14_03400	COG0348	domain, Protein
EGH14_03410	COG2070	2-Nitropropane dioxygenase
EGH14_03490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EGH14_03540	COG1518	maintenance of DNA repeat elements
EGH14_03590	COG3945	hemerythrin HHE cation binding domain
EGH14_03615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGH14_03625	COG0859	PFAM glycosyl transferase family 9
EGH14_03655	COG0277	FAD linked oxidase domain protein
EGH14_03675	COG1562	ergosterol biosynthetic process
EGH14_03715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGH14_03745	COG0765	amino acid transport
EGH14_03770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EGH14_03780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGH14_03790	COG0589	response to stress
EGH14_03870	COG0590	tRNA wobble adenosine to inosine editing
EGH14_03905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EGH14_03905	COG2813	Specifically methylates the guanine in position
EGH14_03945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EGH14_03945	COG0678	peroxiredoxin activity
EGH14_03975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EGH14_03995	COG0567	Dehydrogenase, E1 component
EGH14_04000	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGH14_04005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGH14_04030	COG2963	transposase activity
EGH14_04035	COG2801	Transposase and inactivated derivatives
EGH14_04040	COG2801	Transposase and inactivated derivatives
EGH14_04055	COG1139	Iron-sulfur cluster binding protein
EGH14_04065	COG0247	lactate metabolic process
EGH14_04070	COG0477	Major facilitator Superfamily
EGH14_04075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGH14_04080	COG0791	NLP P60 protein
EGH14_04140	COG0277	FAD linked oxidase domain protein
EGH14_04160	COG1773	rubredoxin
EGH14_04175	COG2963	transposase activity
EGH14_04180	COG2801	Transposase and inactivated derivatives
EGH14_04185	COG2801	Transposase and inactivated derivatives
EGH14_04210	COG4150	thiosulfate binding
EGH14_04220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGH14_04250	COG0586	Pfam SNARE associated Golgi protein
EGH14_04265	COG1476	TRANSCRIPTIONal
EGH14_04290	COG2841	Protein conserved in bacteria
EGH14_04310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EGH14_04380	COG3318	Belongs to the UPF0149 family
EGH14_04380	COG3012	SEC-C Motif Domain Protein
EGH14_04390	COG2866	Carboxypeptidase
EGH14_04415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGH14_04445	COG0300	oxidoreductase activity
EGH14_04450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EGH14_04455	COG1562	ergosterol biosynthetic process
EGH14_04500	COG2975	iron-sulfur cluster assembly
EGH14_04520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGH14_04540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGH14_04620	COG0557	exoribonuclease II activity
EGH14_04675	COG0628	permease
EGH14_04705	COG1192	Involved in chromosome partitioning
EGH14_04745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGH14_04800	COG4453	Protein conserved in bacteria
EGH14_05070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EGH14_05130	COG1393	Belongs to the ArsC family
EGH14_05135	COG0488	(ABC) transporter
EGH14_05180	COG0307	riboflavin synthase, alpha
EGH14_05190	COG3850	Histidine kinase
EGH14_05195	COG2197	response regulator
EGH14_05230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EGH14_05255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGH14_05280	COG0210	DNA helicase
EGH14_05325	COG3676	manually curated
EGH14_05375	COG3093	addiction module antidote protein HigA
EGH14_05435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EGH14_05445	COG0800	Aldolase
EGH14_05460	COG1194	a g-specific adenine glycosylase
EGH14_05540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGH14_05595	COG2217	Heavy metal translocating P-type atpase
EGH14_05600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGH14_05610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGH14_05675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EGH14_05685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGH14_05685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGH14_05700	COG1012	belongs to the aldehyde dehydrogenase family
EGH14_05705	COG2095	MarC family integral membrane protein
EGH14_05720	COG2990	Protein conserved in bacteria
EGH14_05730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EGH14_05730	COG0543	2 iron, 2 sulfur cluster binding
EGH14_05760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGH14_05785	COG0513	Belongs to the DEAD box helicase family
EGH14_05840	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EGH14_05845	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EGH14_05850	COG3421	Type III restriction
EGH14_05855	COG1304	FMN binding
EGH14_05885	COG0822	iron-sulfur transferase activity
EGH14_05890	COG0316	Belongs to the HesB IscA family
EGH14_05895	COG3036	rescue of stalled ribosome
EGH14_05910	COG3676	manually curated
EGH14_05925	COG2951	lytic endotransglycosylase activity
EGH14_05940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGH14_05975	COG0633	Ferredoxin
EGH14_05980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGH14_05985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGH14_06020	COG0741	lytic transglycosylase activity
EGH14_06020	COG1388	LysM domain
EGH14_06030	COG0733	neurotransmitter:sodium symporter activity
EGH14_06050	COG0789	Transcriptional regulator
EGH14_06060	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EGH14_06065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EGH14_06125	COG1183	phosphatidylcholine synthase activity
EGH14_06130	COG0730	response to heat
EGH14_06160	COG0492	ferredoxin-NADP+ reductase activity
EGH14_06165	COG2217	Heavy metal translocating P-type atpase
EGH14_06205	COG0793	Belongs to the peptidase S41A family
EGH14_06220	COG3045	CreA protein
EGH14_06235	COG0179	Fumarylacetoacetate (FAA) hydrolase
EGH14_06250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EGH14_06255	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGH14_06265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGH14_06285	COG3676	manually curated
EGH14_06300	COG1027	Aspartate ammonia-lyase
EGH14_06320	COG0697	spore germination
EGH14_06335	COG0251	oxidation-reduction process
EGH14_06360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGH14_06365	COG0523	cobalamin synthesis protein
EGH14_06375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGH14_06410	COG2814	Major facilitator Superfamily
EGH14_06430	COG0318	PFAM AMP-dependent synthetase and ligase
EGH14_06435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EGH14_06605	COG5410	chromosome segregation
EGH14_06660	COG0305	Participates in initiation and elongation during chromosome replication
EGH14_06930	COG0564	pseudouridine synthase activity
EGH14_06935	COG0561	phosphatase activity
EGH14_06945	COG3676	manually curated
EGH14_06950	COG0347	Belongs to the P(II) protein family
EGH14_06965	COG0640	Transcriptional regulator
EGH14_06980	COG2239	Acts as a magnesium transporter
EGH14_06995	COG0791	NLP P60 protein
EGH14_07010	COG1380	Effector of murein hydrolase LrgA
EGH14_07015	COG1346	cytolysis
EGH14_07025	COG0038	chloride channel
EGH14_07030	COG1643	Atp-dependent helicase
EGH14_07050	COG1643	Atp-dependent helicase
EGH14_07085	COG0512	Glutamine amidotransferase of anthranilate synthase
EGH14_07135	COG0318	PFAM AMP-dependent synthetase and ligase
EGH14_07165	COG1349	DNA-binding transcription factor activity
EGH14_07170	COG2431	L-lysine efflux transmembrane transporter activity
EGH14_07175	COG1802	Transcriptional regulator
EGH14_07185	COG1765	OsmC-like protein
EGH14_07195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGH14_07225	COG1049	propionate catabolic process, 2-methylcitrate cycle
EGH14_07250	COG0028	Belongs to the TPP enzyme family
EGH14_07260	COG1999	signal sequence binding
EGH14_07290	COG2084	Dehydrogenase
EGH14_07305	COG0616	signal peptide processing
EGH14_07330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EGH14_07340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EGH14_07475	COG1619	proteins homologs of microcin C7 resistance protein MccF
EGH14_07490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGH14_07515	COG0778	Nitroreductase
EGH14_07520	COG2194	sulfuric ester hydrolase activity
EGH14_07550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGH14_07560	COG1272	protein, Hemolysin III
EGH14_07565	COG1115	amino acid carrier protein
EGH14_07640	COG3676	manually curated
EGH14_07710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGH14_07715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGH14_07735	COG0561	phosphatase activity
EGH14_07770	COG3676	manually curated
EGH14_07780	COG2995	paraquat-inducible protein a
EGH14_07785	COG3008	intermembrane lipid transfer
EGH14_07785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGH14_07795	COG0519	Catalyzes the synthesis of GMP from XMP
EGH14_07835	COG3245	cytochrome
EGH14_07845	COG1448	Aminotransferase
EGH14_07865	COG0187	DNA topoisomerase II activity
EGH14_07880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGH14_07895	COG0252	asparaginase activity
EGH14_07900	COG0586	Pfam SNARE associated Golgi protein
EGH14_07915	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EGH14_07945	COG1028	Short-chain dehydrogenase reductase Sdr
EGH14_07980	COG0733	neurotransmitter:sodium symporter activity
EGH14_07995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGH14_08005	COG2186	Transcriptional regulator
EGH14_08010	COG1620	l-lactate permease
EGH14_08025	COG1538	Outer membrane efflux protein
EGH14_08050	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EGH14_08055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EGH14_08070	COG2010	Cytochrome c
EGH14_08085	COG3278	Belongs to the heme-copper respiratory oxidase family
EGH14_08095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGH14_08095	COG3453	Protein conserved in bacteria
EGH14_08115	COG1994	Peptidase M50
EGH14_08120	COG2999	glutathione oxidoreductase activity
EGH14_08130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGH14_08240	COG3676	manually curated
EGH14_08250	COG0644	oxidoreductase
EGH14_08250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EGH14_08260	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EGH14_08280	COG3901	Regulator of nitric oxide reductase transcription
EGH14_08280	COG0348	domain, Protein
EGH14_08320	COG1522	sequence-specific DNA binding
EGH14_08330	COG2832	Protein of unknown function (DUF454)
EGH14_08345	COG3676	manually curated
EGH14_08380	COG1477	protein flavinylation
EGH14_08385	COG2991	Protein conserved in bacteria
EGH14_08395	COG1045	serine acetyltransferase
EGH14_08445	COG1116	anion transmembrane transporter activity
EGH14_08460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGH14_08465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGH14_08475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGH14_08485	COG1064	alcohol dehydrogenase
EGH14_08495	COG1196	nuclear chromosome segregation
EGH14_08520	COG1620	l-lactate permease
EGH14_08540	COG1448	Aminotransferase
EGH14_08620	COG0560	Phosphoserine phosphatase
EGH14_08630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EGH14_08640	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EGH14_08645	COG2249	NAD(P)H dehydrogenase (quinone) activity
EGH14_08655	COG0583	DNA-binding transcription factor activity
EGH14_08690	COG0500	methyltransferase
EGH14_08695	COG2830	Protein of unknown function (DUF452)
EGH14_08705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGH14_08710	COG1376	ErfK ybiS ycfS ynhG family protein
EGH14_08715	COG0471	metal ion transport
EGH14_08825	COG0802	atpase or kinase
EGH14_08875	COG2814	Major facilitator Superfamily
EGH14_08885	COG0697	spore germination
EGH14_08910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGH14_08915	COG0287	Prephenate dehydrogenase
EGH14_08935	COG1959	2 iron, 2 sulfur cluster binding
EGH14_08940	COG0009	L-threonylcarbamoyladenylate synthase
EGH14_08970	COG0372	Belongs to the citrate synthase family
EGH14_08985	COG2252	PERMEase
EGH14_09060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGH14_09065	COG2194	sulfuric ester hydrolase activity
EGH14_09130	COG2960	long-chain fatty acid transporting porin activity
EGH14_09190	COG0708	Exodeoxyribonuclease III
EGH14_09245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGH14_09270	COG0488	(ABC) transporter
EGH14_09275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGH14_09280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EGH14_09305	COG0583	DNA-binding transcription factor activity
EGH14_09310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGH14_09315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGH14_09430	COG2814	Major facilitator Superfamily
EGH14_09460	COG1137	ATPase activity
EGH14_09465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EGH14_09475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EGH14_09625	COG0305	Participates in initiation and elongation during chromosome replication
EGH14_09750	COG0569	domain protein
EGH14_09770	COG3676	manually curated
EGH14_09785	COG0351	phosphomethylpyrimidine kinase
EGH14_09865	COG3617	BRO family, N-terminal domain
EGH14_09895	COG2350	Protein conserved in bacteria
EGH14_09920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EGH14_09935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGH14_10000	COG0142	geranyltranstransferase activity
EGH14_10060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EGH14_10070	COG0739	heme binding
EGH14_10125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGH14_10205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGH14_10230	COG2259	Doxx family
EGH14_10235	COG0583	DNA-binding transcription factor activity
EGH14_10240	COG0415	Belongs to the DNA photolyase family
EGH14_10245	COG1199	ATP-dependent helicase activity
EGH14_10255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGH14_10275	COG0557	exoribonuclease II activity
EGH14_10280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGH14_10295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EGH14_10315	COG0514	ATP-dependent DNA helicase (RecQ)
EGH14_10325	COG2226	methyltransferase
EGH14_10335	COG1040	competence protein
EGH14_10340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGH14_10370	COG1132	(ABC) transporter
EGH14_10385	COG0142	geranyltranstransferase activity
EGH14_10445	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EGH14_10450	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EGH14_10470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EGH14_10485	COG3676	manually curated
EGH14_10515	COG0210	DNA helicase
EGH14_10550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGH14_10585	COG0753	catalase activity
EGH14_10600	COG1858	cytochrome C peroxidase
EGH14_10610	COG0339	signal peptide processing
EGH14_10630	COG1760	l-serine dehydratase
EGH14_10670	COG2878	Part of a membrane complex involved in electron transport
EGH14_10675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EGH14_10725	COG1530	ribonuclease E activity
EGH14_10735	COG1115	amino acid carrier protein
EGH14_10755	COG1192	Involved in chromosome partitioning
EGH14_10855	COG1115	amino acid carrier protein
EGH14_10960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGH14_10970	COG0201	protein transport
EGH14_11175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGH14_11205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGH14_11210	COG0742	ribosomal rna small subunit methyltransferase
EGH14_11240	COG0758	DNA mediated transformation
EGH14_11245	COG2204	response regulator
EGH14_11250	COG5000	phosphorelay sensor kinase activity
EGH14_11280	COG1652	LysM domain
EGH14_11330	COG0469	pyruvate kinase activity
EGH14_11360	COG0786	glutamate:sodium symporter activity
EGH14_11415	COG1297	OPT oligopeptide transporter protein
EGH14_11485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EGH14_11490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EGH14_11515	COG1289	transmembrane transporter activity
EGH14_11560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EGH14_11565	COG1519	Transferase
EGH14_11575	COG0861	Integral membrane protein TerC family
EGH14_11605	COG2884	Cell division ATP-binding protein ftsE
EGH14_11615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGH14_11670	COG1335	isochorismatase
EGH14_11675	COG0859	PFAM glycosyl transferase family 9
EGH14_11690	COG1739	Uncharacterized protein family UPF0029
EGH14_11730	COG1595	DNA-templated transcription, initiation
EGH14_11735	COG3219	Protein conserved in bacteria
EGH14_11750	COG2259	Doxx family
EGH14_11775	COG3104	oligopeptide transport
EGH14_11785	COG0729	surface antigen
EGH14_11840	COG1546	Belongs to the CinA family
EGH14_11840	COG1058	Belongs to the CinA family
EGH14_11845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EGH14_11845	COG0616	signal peptide processing
EGH14_12020	COG0024	Methionine aminopeptidase
EGH14_12050	COG3038	cytochrome b561
EGH14_12080	COG0708	Exodeoxyribonuclease III
EGH14_12135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGH14_12195	COG0312	modulator of DNA gyrase
EGH14_12200	COG0765	amino acid transport
EGH14_12210	COG1126	abc transporter atp-binding protein
EGH14_12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGH14_12225	COG2056	Na+-H+ antiporter family
EGH14_12245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EGH14_12295	COG0583	DNA-binding transcription factor activity
EGH14_12305	COG0723	plastoquinol--plastocyanin reductase activity
EGH14_12310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EGH14_12315	COG2857	Cytochrome c1
EGH14_12325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGH14_12330	COG1793	dna ligase
EGH14_12355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGH14_12360	COG3842	ATPase activity
EGH14_12440	COG2824	Alkylphosphonate utilization operon protein PhnA
EGH14_12470	COG1546	Belongs to the CinA family
EGH14_12650	COG1368	sulfuric ester hydrolase activity
EGH14_12660	COG0814	amino acid
EGH14_12680	COG3265	gluconokinase activity
EGH14_12695	COG0288	reversible hydration of carbon dioxide
EGH14_12705	COG0799	negative regulation of ribosome biogenesis
EGH14_12735	COG3676	manually curated
EGH14_12740	COG4604	ABC transporter, ATP-binding protein
EGH14_12755	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGH14_12790	COG0733	neurotransmitter:sodium symporter activity
EGH14_12820	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
EGH14_12890	COG0512	Glutamine amidotransferase of anthranilate synthase
EGH14_12890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EGH14_12900	COG1012	belongs to the aldehyde dehydrogenase family
EGH14_12920	COG1127	ABC transporter
EGH14_12925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGH14_12930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EGH14_12935	COG2854	intermembrane phospholipid transfer
EGH14_12955	COG0824	Thioesterase
EGH14_12985	COG0625	glutathione transferase activity
EGH14_12990	COG2969	positive regulation of protein catabolic process
EGH14_13015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGH14_13020	COG2011	ABC-type metal ion transport system permease component
EGH14_13025	COG1464	Belongs to the NlpA lipoprotein family
EGH14_13060	COG0356	it plays a direct role in the translocation of protons across the membrane
EGH14_13120	COG1442	glycosyl transferase family 8
EGH14_13135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGH14_13140	COG0483	inositol monophosphate 1-phosphatase activity
EGH14_13155	COG1028	Short-chain dehydrogenase reductase Sdr
EGH14_13170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGH14_13220	COG1399	metal-binding, possibly nucleic acid-binding protein