locus-tag	class	description
FCL41_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FCL41_00010	COG0592	DNA-directed DNA polymerase activity
FCL41_00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FCL41_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FCL41_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FCL41_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FCL41_00115	COG0457	Tetratricopeptide repeat
FCL41_00115	COG0705	Rhomboid family
FCL41_00130	COG0515	serine threonine protein kinase
FCL41_00135	COG0515	serine threonine protein kinase
FCL41_00155	COG1716	ATPase activity
FCL41_00175	COG1595	DNA-templated transcription, initiation
FCL41_00205	COG0488	(ABC) transporter
FCL41_00225	COG0386	Belongs to the glutathione peroxidase family
FCL41_00235	COG2409	Drug exporters of the RND superfamily
FCL41_00265	COG0733	neurotransmitter:sodium symporter activity
FCL41_00290	COG0745	RESPONSE REGULATOR receiver
FCL41_00295	COG2205	protein histidine kinase activity
FCL41_00300	COG3590	peptidase
FCL41_00315	COG0514	ATP-dependent DNA helicase (RecQ)
FCL41_00320	COG3832	glyoxalase III activity
FCL41_00325	COG0477	Major facilitator Superfamily
FCL41_00335	COG0386	Belongs to the glutathione peroxidase family
FCL41_00345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL41_00365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL41_00400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FCL41_00410	COG0659	secondary active sulfate transmembrane transporter activity
FCL41_00415	COG0492	ferredoxin-NADP+ reductase activity
FCL41_00420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FCL41_00485	COG0653	protein targeting
FCL41_00510	COG2318	DinB family
FCL41_00540	COG4585	Histidine kinase
FCL41_00545	COG2197	response regulator
FCL41_00550	COG0577	efflux transmembrane transporter activity
FCL41_00550	COG1136	(ABC) transporter
FCL41_00555	COG1136	(ABC) transporter
FCL41_00555	COG0577	efflux transmembrane transporter activity
FCL41_00560	COG2814	Major facilitator Superfamily
FCL41_00585	COG2353	YceI-like domain
FCL41_00620	COG0446	pyridine nucleotide-disulphide oxidoreductase
FCL41_00620	COG1902	pentaerythritol trinitrate reductase activity
FCL41_00625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_00650	COG0702	epimerase
FCL41_00665	COG1695	Transcriptional regulator
FCL41_00670	COG1136	(ABC) transporter
FCL41_00670	COG0577	efflux transmembrane transporter activity
FCL41_00685	COG0183	Belongs to the thiolase family
FCL41_00705	COG0697	spore germination
FCL41_00715	COG4152	abc transporter atp-binding protein
FCL41_00760	COG1960	acyl-CoA dehydrogenase activity
FCL41_00765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL41_00800	COG0488	(ABC) transporter
FCL41_00815	COG1595	DNA-templated transcription, initiation
FCL41_00865	COG1595	DNA-templated transcription, initiation
FCL41_00895	COG3119	arylsulfatase activity
FCL41_00915	COG0745	RESPONSE REGULATOR receiver
FCL41_00925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FCL41_00930	COG1950	PFAM Membrane protein of
FCL41_00945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FCL41_00950	COG0435	Glutathione S-transferase
FCL41_00965	COG0477	Major facilitator Superfamily
FCL41_00980	COG0022	dehydrogenase e1 component
FCL41_00985	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL41_01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL41_01030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL41_01035	COG1120	ATPase activity
FCL41_01065	COG1116	anion transmembrane transporter activity
FCL41_01070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL41_01155	COG1233	COG1233 Phytoene dehydrogenase and related
FCL41_01175	COG1960	acyl-CoA dehydrogenase activity
FCL41_01180	COG0730	response to heat
FCL41_01195	COG1595	DNA-templated transcription, initiation
FCL41_01215	COG0717	Belongs to the dCTP deaminase family
FCL41_01230	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_01235	COG0477	Major facilitator Superfamily
FCL41_01250	COG2181	nitrate reductase activity
FCL41_01250	COG0247	lactate metabolic process
FCL41_01265	COG2986	histidine ammonia-lyase
FCL41_01270	COG1733	regulation of RNA biosynthetic process
FCL41_01285	COG1122	ATPase activity
FCL41_01315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FCL41_01325	COG2301	Belongs to the HpcH HpaI aldolase family
FCL41_01330	COG2301	Belongs to the HpcH HpaI aldolase family
FCL41_01345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL41_01350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FCL41_01350	COG2111	Na H antiporter
FCL41_01355	COG1006	Multisubunit Na H antiporter MnhC subunit
FCL41_01375	COG1320	monovalent cation:proton antiporter activity
FCL41_01380	COG0778	Nitroreductase
FCL41_01380	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FCL41_01395	COG1228	amidohydrolase
FCL41_01415	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FCL41_01415	COG1672	PFAM Archaeal ATPase
FCL41_01425	COG2814	Major facilitator Superfamily
FCL41_01440	COG0443	Heat shock 70 kDa protein
FCL41_01445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FCL41_01450	COG0484	heat shock protein binding
FCL41_01455	COG0789	Transcriptional regulator
FCL41_01460	COG2201	protein-glutamate methylesterase activity
FCL41_01480	COG0542	response to heat
FCL41_01495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FCL41_01500	COG0586	Pfam SNARE associated Golgi protein
FCL41_01505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FCL41_01505	COG0357	Ribosomal RNA small subunit methyltransferase G
FCL41_01525	COG0191	fructose-bisphosphate aldolase activity
FCL41_01540	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FCL41_01550	COG1597	lipid kinase activity
FCL41_01555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FCL41_01565	COG0300	oxidoreductase activity
FCL41_01570	COG0151	Belongs to the GarS family
FCL41_01575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FCL41_01585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FCL41_01600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FCL41_01620	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FCL41_01635	COG0047	phosphoribosylformylglycinamidine synthase activity
FCL41_01680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FCL41_01685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FCL41_01735	COG5002	protein histidine kinase activity
FCL41_01745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FCL41_01795	COG1252	NADH dehydrogenase
FCL41_01825	COG3123	guanosine phosphorylase activity
FCL41_01875	COG0789	Transcriptional regulator
FCL41_01910	COG1278	Cold shock
FCL41_01915	COG1937	Protein conserved in bacteria
FCL41_01920	COG2608	mercury ion transmembrane transporter activity
FCL41_01935	COG1131	(ABC) transporter
FCL41_01940	COG3559	Exporter of polyketide antibiotics
FCL41_01965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FCL41_01970	COG0306	phosphate transporter
FCL41_01985	COG1490	D-aminoacyl-tRNA deacylase activity
FCL41_01990	COG3246	L-lysine catabolic process to acetate
FCL41_02005	COG4044	May play a role in the intracellular transport of hydrophobic ligands
FCL41_02010	COG0735	belongs to the Fur family
FCL41_02020	COG0454	-acetyltransferase
FCL41_02020	COG0456	acetyltransferase
FCL41_02025	COG0745	RESPONSE REGULATOR receiver
FCL41_02055	COG2755	lipolytic protein G-D-S-L family
FCL41_02055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FCL41_02060	COG1403	HNH endonuclease
FCL41_02080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FCL41_02085	COG0584	glycerophosphoryl diester phosphodiesterase
FCL41_02110	COG1086	Polysaccharide biosynthesis protein
FCL41_02115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FCL41_02120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FCL41_02185	COG0730	response to heat
FCL41_02190	COG0529	Catalyzes the synthesis of activated sulfate
FCL41_02210	COG1086	Polysaccharide biosynthesis protein
FCL41_02215	COG0662	Cupin 2, conserved barrel domain protein
FCL41_02215	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FCL41_02220	COG0438	transferase activity, transferring glycosyl groups
FCL41_02225	COG1091	dTDP-4-dehydrorhamnose reductase activity
FCL41_02230	COG1088	dTDP-glucose 4,6-dehydratase activity
FCL41_02245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FCL41_02270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FCL41_02285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FCL41_02305	COG3842	ATPase activity
FCL41_02310	COG1176	ABC-type spermidine putrescine transport system, permease component I
FCL41_02330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_02340	COG2301	Belongs to the HpcH HpaI aldolase family
FCL41_02350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL41_02360	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_02365	COG0183	Belongs to the thiolase family
FCL41_02370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_02400	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_02410	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FCL41_02425	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_02445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_02480	COG0463	Glycosyl transferase, family 2
FCL41_02515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL41_02520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FCL41_02530	COG1703	isobutyryl-CoA mutase activity
FCL41_02530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL41_02530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FCL41_02560	COG0183	Belongs to the thiolase family
FCL41_02580	COG4608	Belongs to the ABC transporter superfamily
FCL41_02590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL41_02595	COG0601	transmembrane transport
FCL41_02600	COG0789	Transcriptional regulator
FCL41_02610	COG1960	acyl-CoA dehydrogenase activity
FCL41_02615	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FCL41_02640	COG2318	DinB family
FCL41_02650	COG1966	Carbon starvation protein
FCL41_02670	COG0431	NADPH-dependent FMN reductase
FCL41_02725	COG1528	Iron-storage protein
FCL41_02735	COG1794	racemase activity, acting on amino acids and derivatives
FCL41_02765	COG0438	transferase activity, transferring glycosyl groups
FCL41_02775	COG0697	spore germination
FCL41_02780	COG0745	RESPONSE REGULATOR receiver
FCL41_02785	COG5002	protein histidine kinase activity
FCL41_02795	COG0588	phosphoglycerate mutase activity
FCL41_02805	COG1329	Transcriptional regulator
FCL41_02815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FCL41_02825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FCL41_02850	COG0215	cysteine-tRNA ligase activity
FCL41_02870	COG3663	DNA glycosylase
FCL41_02885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FCL41_02905	COG1643	Atp-dependent helicase
FCL41_02945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FCL41_02950	COG0583	DNA-binding transcription factor activity
FCL41_02965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_02970	COG0431	NADPH-dependent FMN reductase
FCL41_02995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL41_03010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FCL41_03010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FCL41_03025	COG0438	transferase activity, transferring glycosyl groups
FCL41_03035	COG1793	dna ligase
FCL41_03065	COG0395	ABC-type sugar transport system, permease component
FCL41_03070	COG2723	6-phospho-beta-galactosidase activity
FCL41_03080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FCL41_03085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FCL41_03105	COG0193	aminoacyl-tRNA hydrolase activity
FCL41_03110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FCL41_03130	COG3291	Pkd domain containing protein
FCL41_03130	COG4412	M6 family metalloprotease domain protein
FCL41_03170	COG1218	3'(2'),5'-bisphosphate nucleotidase
FCL41_03190	COG3956	TIGRFAM MazG family protein
FCL41_03195	COG0148	phosphopyruvate hydratase activity
FCL41_03230	COG0242	peptide deformylase activity
FCL41_03270	COG1739	Uncharacterized protein family UPF0029
FCL41_03275	COG3012	SEC-C Motif Domain Protein
FCL41_03290	COG4867	von Willebrand factor, type A
FCL41_03310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FCL41_03325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FCL41_03330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FCL41_03340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FCL41_03360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FCL41_03365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FCL41_03380	COG2409	Drug exporters of the RND superfamily
FCL41_03390	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_03395	COG0114	fumarate hydratase activity
FCL41_03410	COG0693	protein deglycase activity
FCL41_03415	COG2267	carboxylic ester hydrolase activity
FCL41_03430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FCL41_03430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FCL41_03435	COG0352	thiamine-phosphate diphosphorylase activity
FCL41_03450	COG2022	thiamine diphosphate biosynthetic process
FCL41_03455	COG0352	thiamine-phosphate diphosphorylase activity
FCL41_03460	COG0351	phosphomethylpyrimidine kinase
FCL41_03465	COG0667	Aldo Keto reductase
FCL41_03510	COG1722	exodeoxyribonuclease VII activity
FCL41_03515	COG1570	exodeoxyribonuclease VII activity
FCL41_03520	COG2890	protein-(glutamine-N5) methyltransferase activity
FCL41_03525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FCL41_03530	COG0009	L-threonylcarbamoyladenylate synthase
FCL41_03540	COG1322	Protein conserved in bacteria
FCL41_03545	COG0708	Exodeoxyribonuclease III
FCL41_03570	COG0012	GTP binding
FCL41_03580	COG0662	Cupin 2, conserved barrel domain protein
FCL41_03605	COG2267	carboxylic ester hydrolase activity
FCL41_03640	COG0798	PFAM Bile acid sodium symporter
FCL41_03645	COG2226	methyltransferase
FCL41_03650	COG0640	Transcriptional regulator
FCL41_03700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL41_03715	COG3206	protein involved in exopolysaccharide biosynthesis
FCL41_03715	COG0489	protein tyrosine kinase activity
FCL41_03740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FCL41_03770	COG4604	ABC transporter, ATP-binding protein
FCL41_03775	COG4605	iron ion homeostasis
FCL41_03780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL41_03785	COG4607	ABC-type enterochelin transport system periplasmic component
FCL41_03795	COG2171	N-acyltransferase activity
FCL41_03815	COG2318	DinB family
FCL41_03820	COG2318	DinB family
FCL41_03855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL41_03885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FCL41_03910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FCL41_03955	COG2902	Dehydrogenase
FCL41_03960	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FCL41_04110	COG0477	Major facilitator Superfamily
FCL41_04115	COG0583	DNA-binding transcription factor activity
FCL41_04120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FCL41_04130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL41_04135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_04145	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FCL41_04155	COG2884	Cell division ATP-binding protein ftsE
FCL41_04165	COG0739	heme binding
FCL41_04165	COG0741	lytic transglycosylase activity
FCL41_04165	COG1196	nuclear chromosome segregation
FCL41_04170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FCL41_04200	COG0668	transmembrane transport
FCL41_04205	COG1764	response to oxidative stress
FCL41_04220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL41_04250	COG1678	Uncharacterized ACR, COG1678
FCL41_04280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FCL41_04300	COG1126	abc transporter atp-binding protein
FCL41_04305	COG0765	amino acid transport
FCL41_04315	COG1024	Enoyl-CoA hydratase
FCL41_04320	COG1335	isochorismatase
FCL41_04335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FCL41_04375	COG1131	(ABC) transporter
FCL41_04385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FCL41_04390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FCL41_04405	COG1131	(ABC) transporter
FCL41_04425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FCL41_04430	COG5002	protein histidine kinase activity
FCL41_04465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FCL41_04485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FCL41_04505	COG1742	UPF0060 membrane protein
FCL41_04560	COG2066	Belongs to the glutaminase family
FCL41_04600	COG0589	response to stress
FCL41_04610	COG2233	PERMEase
FCL41_04620	COG1024	Enoyl-CoA hydratase
FCL41_04620	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL41_04630	COG0006	proline dipeptidase activity
FCL41_04645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FCL41_04665	COG0824	Thioesterase
FCL41_04675	COG0668	transmembrane transport
FCL41_04695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FCL41_04710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL41_04725	COG0698	ribose 5-phosphate isomerase
FCL41_04750	COG0544	peptidyl-prolyl cis-trans isomerase activity
FCL41_04755	COG0740	serine-type endopeptidase activity
FCL41_04760	COG0740	serine-type endopeptidase activity
FCL41_04765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FCL41_04775	COG0525	valine-tRNA ligase activity
FCL41_04795	COG0285	dihydrofolate synthase activity
FCL41_04815	COG0105	UTP biosynthetic process
FCL41_04825	COG1077	Cell shape determining protein MreB Mrl
FCL41_04840	COG0768	penicillin binding
FCL41_04845	COG0772	Belongs to the SEDS family
FCL41_04850	COG0387	Pfam Sodium calcium exchanger
FCL41_04870	COG2807	transmembrane transport
FCL41_04880	COG1530	ribonuclease E activity
FCL41_04885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FCL41_04890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FCL41_04895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FCL41_04900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FCL41_04910	COG0482	sulfurtransferase activity
FCL41_05020	COG0598	Magnesium transport protein CorA
FCL41_05045	COG1131	(ABC) transporter
FCL41_05095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FCL41_05105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FCL41_05110	COG0154	amidase activity
FCL41_05115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FCL41_05135	COG3845	ABC transporter
FCL41_05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_05170	COG0129	dihydroxy-acid dehydratase activity
FCL41_05215	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FCL41_05220	COG0672	)-iron permease
FCL41_05230	COG2837	iron assimilation
FCL41_05240	COG1131	(ABC) transporter
FCL41_05245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FCL41_05255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FCL41_05270	COG0473	3-isopropylmalate dehydrogenase activity
FCL41_05275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FCL41_05285	COG0154	amidase activity
FCL41_05295	COG1122	ATPase activity
FCL41_05300	COG1268	BioY protein
FCL41_05325	COG0179	Fumarylacetoacetate (FAA) hydrolase
FCL41_05330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FCL41_05330	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FCL41_05360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FCL41_05380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FCL41_05385	COG0066	3-isopropylmalate dehydratase activity
FCL41_05400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FCL41_05410	COG1181	Belongs to the D-alanine--D-alanine ligase family
FCL41_05430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FCL41_05435	COG1461	Dihydroxyacetone kinase
FCL41_05445	COG0742	ribosomal rna small subunit methyltransferase
FCL41_05450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FCL41_05460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FCL41_05465	COG0571	ribonuclease III activity
FCL41_05470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FCL41_05515	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FCL41_05550	COG0228	four-way junction DNA binding
FCL41_05555	COG1837	Belongs to the UPF0109 family
FCL41_05560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FCL41_05565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FCL41_05570	COG0336	Belongs to the RNA methyltransferase TrmD family
FCL41_05575	COG0335	large ribosomal subunit rRNA binding
FCL41_05580	COG0681	Belongs to the peptidase S26 family
FCL41_05585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FCL41_05600	COG0792	nuclease activity
FCL41_05605	COG0606	chelatase, subunit chli
FCL41_05615	COG4974	Belongs to the 'phage' integrase family
FCL41_05625	COG0052	Belongs to the universal ribosomal protein uS2 family
FCL41_05630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FCL41_05635	COG0528	UMP kinase activity
FCL41_05640	COG0233	cytoplasmic translational termination
FCL41_05655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FCL41_05665	COG0515	serine threonine protein kinase
FCL41_05665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FCL41_05695	COG0750	zinc metalloprotease
FCL41_05700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FCL41_05710	COG0442	prolyl-tRNA aminoacylation
FCL41_05730	COG0779	Required for maturation of 30S ribosomal subunits
FCL41_05750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FCL41_05755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FCL41_05765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FCL41_05775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FCL41_05780	COG1349	DNA-binding transcription factor activity
FCL41_05785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL41_05790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FCL41_05795	COG1185	polyribonucleotide nucleotidyltransferase activity
FCL41_05800	COG0612	Peptidase, M16
FCL41_05820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FCL41_05860	COG0501	Belongs to the peptidase M48B family
FCL41_05875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FCL41_05910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FCL41_05915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FCL41_05935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FCL41_05940	COG0723	plastoquinol--plastocyanin reductase activity
FCL41_05950	COG1845	cytochrome c oxidase, subunit III
FCL41_05960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FCL41_05995	COG0463	Glycosyl transferase, family 2
FCL41_06025	COG0501	Belongs to the peptidase M48B family
FCL41_06040	COG2197	response regulator
FCL41_06045	COG4585	Histidine kinase
FCL41_06065	COG2894	cell division
FCL41_06085	COG0003	Pfam Anion-transporting ATPase
FCL41_06095	COG1940	carbohydrate kinase activity
FCL41_06135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FCL41_06140	COG0205	6-phosphofructokinase activity
FCL41_06145	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FCL41_06160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FCL41_06165	COG2815	serine threonine protein kinase
FCL41_06165	COG0515	serine threonine protein kinase
FCL41_06215	COG0587	DNA-directed DNA polymerase activity
FCL41_06220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FCL41_06225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FCL41_06245	COG0714	Associated with various cellular activities
FCL41_06250	COG2001	Belongs to the MraZ family
FCL41_06255	COG0275	rRNA processing
FCL41_06265	COG0768	penicillin binding
FCL41_06270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FCL41_06275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FCL41_06280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FCL41_06285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FCL41_06295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FCL41_06300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FCL41_06305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FCL41_06325	COG1799	cell septum assembly
FCL41_06340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FCL41_06360	COG0587	DNA-directed DNA polymerase activity
FCL41_06370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FCL41_06375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FCL41_06380	COG0131	Imidazoleglycerol-phosphate dehydratase
FCL41_06385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FCL41_06390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FCL41_06395	COG0107	imidazoleglycerol-phosphate synthase activity
FCL41_06400	COG1132	(ABC) transporter
FCL41_06405	COG1132	(ABC) transporter
FCL41_06410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FCL41_06430	COG0134	indole-3-glycerol-phosphate synthase activity
FCL41_06435	COG0133	tryptophan synthase activity
FCL41_06440	COG0159	tryptophan synthase activity
FCL41_06445	COG1999	signal sequence binding
FCL41_06450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FCL41_06455	COG0069	glutamate synthase activity
FCL41_06455	COG0067	glutamate synthase
FCL41_06455	COG0070	glutamate synthase
FCL41_06465	COG0469	pyruvate kinase activity
FCL41_06480	COG1172	Belongs to the binding-protein-dependent transport system permease family
FCL41_06490	COG0411	ABC transporter
FCL41_06495	COG0410	ABC transporter
FCL41_06525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FCL41_06525	COG2755	lipolytic protein G-D-S-L family
FCL41_06540	COG4981	capsule polysaccharide biosynthetic process
FCL41_06555	COG0438	transferase activity, transferring glycosyl groups
FCL41_06580	COG0539	negative regulation of cytoplasmic translation
FCL41_06585	COG0237	dephospho-CoA kinase activity
FCL41_06600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FCL41_06610	COG1984	allophanate hydrolase subunit 2
FCL41_06615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FCL41_06635	COG0589	response to stress
FCL41_06650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FCL41_06675	COG0187	DNA topoisomerase II activity
FCL41_06690	COG0477	Major facilitator Superfamily
FCL41_06700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FCL41_06720	COG1435	thymidine kinase activity
FCL41_06725	COG0667	Aldo Keto reductase
FCL41_06775	COG0756	dUTP diphosphatase activity
FCL41_06800	COG0569	domain protein
FCL41_06805	COG0531	amino acid
FCL41_06810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FCL41_06815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FCL41_06860	COG2154	pterin-4-alpha-carbinolamine dehydratase
FCL41_06865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FCL41_06870	COG0531	amino acid
FCL41_06885	COG1024	Enoyl-CoA hydratase
FCL41_06885	COG1250	3-hydroxyacyl-CoA dehydrogenase
FCL41_06890	COG0183	Belongs to the thiolase family
FCL41_06900	COG1946	Acyl-CoA thioesterase
FCL41_06905	COG0739	heme binding
FCL41_06905	COG1196	nuclear chromosome segregation
FCL41_06905	COG0741	lytic transglycosylase activity
FCL41_06915	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_06920	COG0183	Belongs to the thiolase family
FCL41_06930	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FCL41_06935	COG0540	Belongs to the ATCase OTCase family
FCL41_06940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FCL41_06945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_06955	COG0505	Belongs to the CarA family
FCL41_06960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FCL41_06965	COG0167	dihydroorotate dehydrogenase activity
FCL41_06970	COG0543	2 iron, 2 sulfur cluster binding
FCL41_06975	COG0167	dihydroorotate dehydrogenase activity
FCL41_06980	COG0284	orotidine-5'-phosphate decarboxylase activity
FCL41_06990	COG0194	GDP metabolic process
FCL41_06995	COG1758	RNA polymerase activity
FCL41_07005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FCL41_07010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FCL41_07015	COG0242	peptide deformylase activity
FCL41_07020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FCL41_07045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FCL41_07060	COG3201	nicotinamide mononucleotide transporter
FCL41_07065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL41_07065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FCL41_07070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FCL41_07075	COG0140	phosphoribosyl-ATP diphosphatase activity
FCL41_07080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FCL41_07100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FCL41_07100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FCL41_07120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FCL41_07125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FCL41_07130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FCL41_07150	COG5002	protein histidine kinase activity
FCL41_07155	COG0745	RESPONSE REGULATOR receiver
FCL41_07160	COG2205	protein histidine kinase activity
FCL41_07165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FCL41_07170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FCL41_07170	COG0072	phenylalanine-tRNA ligase activity
FCL41_07180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FCL41_07190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FCL41_07195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FCL41_07200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FCL41_07205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FCL41_07210	COG1438	arginine binding
FCL41_07215	COG0137	argininosuccinate synthase activity
FCL41_07220	COG0165	Argininosuccinate lyase
FCL41_07250	COG0647	UMP catabolic process
FCL41_07265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FCL41_07270	COG0497	DNA recombination
FCL41_07285	COG0504	CTP synthase activity
FCL41_07290	COG0494	nUDIX hydrolase
FCL41_07320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FCL41_07335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FCL41_07340	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_07340	COG0204	Acyl-transferase
FCL41_07345	COG1160	GTP binding
FCL41_07385	COG0582	viral genome integration into host DNA
FCL41_07405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FCL41_07430	COG0204	Acyl-transferase
FCL41_07435	COG2409	Drug exporters of the RND superfamily
FCL41_07445	COG2409	Drug exporters of the RND superfamily
FCL41_07460	COG1755	Isoprenylcysteine carboxyl methyltransferase
FCL41_07475	COG0644	oxidoreductase
FCL41_07480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FCL41_07485	COG5002	protein histidine kinase activity
FCL41_07495	COG1215	transferase activity, transferring glycosyl groups
FCL41_07510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FCL41_07520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FCL41_07540	COG0783	Belongs to the Dps family
FCL41_07570	COG1309	transcriptional regulator
FCL41_07605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_07610	COG3237	CsbD-like
FCL41_07615	COG2860	membrane
FCL41_07620	COG0420	3'-5' exonuclease activity
FCL41_07625	COG0419	ATPase involved in DNA repair
FCL41_07630	COG1012	belongs to the aldehyde dehydrogenase family
FCL41_07635	COG5549	protein import
FCL41_07635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FCL41_07650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FCL41_07655	COG2030	dehydratase
FCL41_07660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_07665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_07680	COG2030	dehydratase
FCL41_07700	COG1960	acyl-CoA dehydrogenase activity
FCL41_07715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FCL41_07740	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FCL41_07750	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FCL41_07755	COG0217	transcriptional regulatory protein
FCL41_07765	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FCL41_07770	COG0632	four-way junction helicase activity
FCL41_07775	COG2255	four-way junction helicase activity
FCL41_07785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FCL41_07790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FCL41_07795	COG1196	nuclear chromosome segregation
FCL41_07805	COG0124	histidyl-tRNA synthetase
FCL41_07810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FCL41_07835	COG4608	Belongs to the ABC transporter superfamily
FCL41_07855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FCL41_07860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FCL41_07865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FCL41_07880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FCL41_07885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FCL41_07890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FCL41_07895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FCL41_07900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FCL41_07905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FCL41_07920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL41_07940	COG2018	Roadblock/LC7 domain
FCL41_07950	COG0556	nucleotide-excision repair
FCL41_07960	COG0492	ferredoxin-NADP+ reductase activity
FCL41_07970	COG2226	methyltransferase
FCL41_07970	COG1073	alpha beta
FCL41_07990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FCL41_08005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FCL41_08020	COG0322	excinuclease ABC activity
FCL41_08025	COG1660	Displays ATPase and GTPase activities
FCL41_08035	COG1481	regulation of sporulation
FCL41_08040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FCL41_08045	COG0126	phosphoglycerate kinase activity
FCL41_08050	COG0149	triose-phosphate isomerase activity
FCL41_08055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FCL41_08065	COG0363	glucosamine-6-phosphate deaminase activity
FCL41_08080	COG0166	Belongs to the GPI family
FCL41_08085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FCL41_08095	COG0109	protoheme IX farnesyltransferase activity
FCL41_08105	COG1612	heme a metabolic process
FCL41_08140	COG0396	ATPase activity
FCL41_08145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FCL41_08150	COG0822	iron-sulfur transferase activity
FCL41_08155	COG2151	metal-sulfur cluster biosynthetic enzyme
FCL41_08185	COG0488	(ABC) transporter
FCL41_08190	COG1024	Enoyl-CoA hydratase
FCL41_08195	COG1132	(ABC) transporter
FCL41_08210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FCL41_08240	COG0560	Phosphoserine phosphatase
FCL41_08240	COG3830	Belongs to the UPF0237 family
FCL41_08250	COG1119	ATPase activity
FCL41_08290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FCL41_08290	COG1648	precorrin-2 dehydrogenase activity
FCL41_08300	COG0242	peptide deformylase activity
FCL41_08305	COG1960	acyl-CoA dehydrogenase activity
FCL41_08310	COG1960	acyl-CoA dehydrogenase activity
FCL41_08315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FCL41_08355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FCL41_08365	COG0667	Aldo Keto reductase
FCL41_08370	COG1968	undecaprenyl-diphosphatase activity
FCL41_08375	COG0598	Magnesium transport protein CorA
FCL41_08395	COG0215	cysteine-tRNA ligase activity
FCL41_08415	COG2323	membrane
FCL41_08420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FCL41_08435	COG1222	aaa ATPase
FCL41_08445	COG4122	O-methyltransferase activity
FCL41_08455	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FCL41_08460	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FCL41_08465	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FCL41_08470	COG0544	peptidyl-prolyl cis-trans isomerase activity
FCL41_08490	COG0805	protein transport
FCL41_08510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FCL41_08515	COG1522	sequence-specific DNA binding
FCL41_08520	COG1509	lysine 2,3-aminomutase activity
FCL41_08525	COG0604	alcohol dehydrogenase
FCL41_08530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FCL41_08535	COG5012	cobalamin binding
FCL41_08540	COG1607	acyl-coa hydrolase
FCL41_08550	COG1216	Glycosyl transferase, family 2
FCL41_08575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FCL41_08585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FCL41_08595	COG0667	Aldo Keto reductase
FCL41_08600	COG2234	aminopeptidase activity
FCL41_08620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FCL41_08655	COG1765	OsmC-like protein
FCL41_08675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FCL41_08680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FCL41_08680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FCL41_08700	COG1716	ATPase activity
FCL41_08705	COG0509	glycine decarboxylation via glycine cleavage system
FCL41_08730	COG1253	flavin adenine dinucleotide binding
FCL41_08740	COG0110	maltose O-acetyltransferase activity
FCL41_08750	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_08765	COG2186	Transcriptional regulator
FCL41_08810	COG0411	ABC transporter
FCL41_08815	COG0410	ABC transporter
FCL41_08830	COG3764	Sortase (surface protein transpeptidase)
FCL41_08875	COG1012	belongs to the aldehyde dehydrogenase family
FCL41_08880	COG1012	belongs to the aldehyde dehydrogenase family
FCL41_08885	COG1960	acyl-CoA dehydrogenase activity
FCL41_08905	COG2814	Major facilitator Superfamily
FCL41_08920	COG1335	isochorismatase
FCL41_08925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_08930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL41_08935	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_08955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FCL41_08985	COG1414	Transcriptional regulator
FCL41_09000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FCL41_09005	COG1122	ATPase activity
FCL41_09045	COG1960	acyl-CoA dehydrogenase activity
FCL41_09050	COG1960	acyl-CoA dehydrogenase activity
FCL41_09065	COG0410	ABC transporter
FCL41_09070	COG0559	Belongs to the binding-protein-dependent transport system permease family
FCL41_09135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL41_09140	COG0789	Transcriptional regulator
FCL41_09145	COG0659	secondary active sulfate transmembrane transporter activity
FCL41_09165	COG0798	PFAM Bile acid sodium symporter
FCL41_09170	COG0640	Transcriptional regulator
FCL41_09180	COG0492	ferredoxin-NADP+ reductase activity
FCL41_09190	COG2072	flavoprotein involved in K transport
FCL41_09215	COG5416	Lipopolysaccharide assembly protein A domain
FCL41_09225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FCL41_09230	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FCL41_09235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FCL41_09255	COG2267	carboxylic ester hydrolase activity
FCL41_09265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FCL41_09275	COG3415	Transposase
FCL41_09275	COG2801	Transposase and inactivated derivatives
FCL41_09330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL41_09605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FCL41_09610	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FCL41_09620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FCL41_09630	COG1960	acyl-CoA dehydrogenase activity
FCL41_09650	COG0175	sulfate reduction
FCL41_09670	COG2326	polyphosphate kinase activity
FCL41_09680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FCL41_09685	COG0477	Major facilitator Superfamily
FCL41_09700	COG1201	RNA secondary structure unwinding
FCL41_09705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FCL41_09710	COG1396	sequence-specific DNA binding
FCL41_09715	COG1058	Belongs to the CinA family
FCL41_09715	COG1546	Belongs to the CinA family
FCL41_09725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL41_09740	COG1674	ftsk spoiiie
FCL41_09760	COG1271	oxidase subunit
FCL41_09765	COG1294	oxidase, subunit
FCL41_09770	COG4988	ABC transporter
FCL41_09775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FCL41_09780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FCL41_09790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FCL41_09800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FCL41_09810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FCL41_09815	COG0384	phenazine biosynthesis protein PhzF
FCL41_09830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FCL41_09835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FCL41_09850	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL41_09865	COG0321	lipoyl(octanoyl) transferase activity
FCL41_09870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FCL41_09890	COG0174	glutamine synthetase
FCL41_09910	COG1131	(ABC) transporter
FCL41_09920	COG0515	serine threonine protein kinase
FCL41_09930	COG0121	glutamine amidotransferase
FCL41_09940	COG0531	amino acid
FCL41_09945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FCL41_09975	COG0590	tRNA wobble adenosine to inosine editing
FCL41_09980	COG0028	Belongs to the TPP enzyme family
FCL41_10015	COG0829	nickel cation binding
FCL41_10020	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FCL41_10030	COG0804	urea catabolic process
FCL41_10035	COG0832	Belongs to the urease beta subunit family
FCL41_10050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FCL41_10055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FCL41_10085	COG2217	Heavy metal translocating P-type atpase
FCL41_10100	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FCL41_10130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FCL41_10130	COG0723	plastoquinol--plastocyanin reductase activity
FCL41_10135	COG2890	protein-(glutamine-N5) methyltransferase activity
FCL41_10170	COG2094	Belongs to the DNA glycosylase MPG family
FCL41_10180	COG0135	phosphoribosylanthranilate isomerase activity
FCL41_10215	COG1215	transferase activity, transferring glycosyl groups
FCL41_10240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FCL41_10250	COG0252	asparaginase activity
FCL41_10325	COG0861	Integral membrane protein TerC family
FCL41_10330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FCL41_10350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FCL41_10380	COG0142	geranyltranstransferase activity
FCL41_10430	COG1643	Atp-dependent helicase
FCL41_10435	COG0121	glutamine amidotransferase
FCL41_10450	COG0579	oxidoreductase
FCL41_10505	COG0778	Nitroreductase
FCL41_10515	COG2409	Drug exporters of the RND superfamily
FCL41_10545	COG1295	ribonuclease BN
FCL41_10550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FCL41_10565	COG1064	alcohol dehydrogenase
FCL41_10570	COG1309	transcriptional regulator
FCL41_10585	COG2186	Transcriptional regulator
FCL41_10600	COG1024	Enoyl-CoA hydratase
FCL41_10620	COG0444	Belongs to the ABC transporter superfamily
FCL41_10630	COG0601	transmembrane transport
FCL41_10635	COG0747	negative chemotaxis
FCL41_10640	COG1960	acyl-CoA dehydrogenase activity
FCL41_10650	COG2814	Major facilitator Superfamily
FCL41_10665	COG3022	response to hydroperoxide
FCL41_10685	COG2205	protein histidine kinase activity
FCL41_10690	COG0745	RESPONSE REGULATOR receiver
FCL41_10715	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_10725	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FCL41_10745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FCL41_10750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FCL41_10790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FCL41_10795	COG0515	serine threonine protein kinase
FCL41_10795	COG2815	serine threonine protein kinase
FCL41_10810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FCL41_10825	COG0358	DNA primase activity
FCL41_10830	COG1295	ribonuclease BN
FCL41_10840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FCL41_10860	COG0423	glycine-tRNA ligase activity
FCL41_10875	COG1121	(ABC) transporter
FCL41_10880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FCL41_10890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FCL41_10895	COG1381	Involved in DNA repair and RecF pathway recombination
FCL41_10900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FCL41_10920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FCL41_10930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FCL41_10950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FCL41_10960	COG0537	adenosine 5'-monophosphoramidase activity
FCL41_10975	COG0484	heat shock protein binding
FCL41_10980	COG1420	regulation of RNA biosynthetic process
FCL41_11005	COG1022	Amp-dependent synthetase and ligase
FCL41_11010	COG0481	GTPase activity
FCL41_11020	COG0268	Binds directly to 16S ribosomal RNA
FCL41_11035	COG2333	competence protein COMEC
FCL41_11035	COG0658	competence protein
FCL41_11045	COG1307	EDD domain protein, DegV family
FCL41_11050	COG0495	leucyl-tRNA aminoacylation
FCL41_11060	COG1335	isochorismatase
FCL41_11075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FCL41_11090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FCL41_11105	COG4608	Belongs to the ABC transporter superfamily
FCL41_11115	COG4106	trans-aconitate 2-methyltransferase activity
FCL41_11130	COG2226	methyltransferase
FCL41_11135	COG1053	succinate dehydrogenase
FCL41_11145	COG0667	Aldo Keto reductase
FCL41_11180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FCL41_11185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FCL41_11190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FCL41_11225	COG0574	Belongs to the PEP-utilizing enzyme family
FCL41_11225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FCL41_11250	COG0183	Belongs to the thiolase family
FCL41_11270	COG0596	Alpha beta hydrolase
FCL41_11290	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FCL41_11325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FCL41_11330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FCL41_11335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FCL41_11340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FCL41_11345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL41_11350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FCL41_11355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FCL41_11360	COG0356	it plays a direct role in the translocation of protons across the membrane
FCL41_11375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FCL41_11385	COG2890	protein-(glutamine-N5) methyltransferase activity
FCL41_11390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FCL41_11395	COG0254	rRNA binding
FCL41_11410	COG0083	homoserine kinase activity
FCL41_11415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FCL41_11420	COG0460	homoserine dehydrogenase
FCL41_11425	COG0019	diaminopimelate decarboxylase activity
FCL41_11430	COG0018	arginyl-trna synthetase
FCL41_11440	COG1316	TRANSCRIPTIONal
FCL41_11450	COG0508	dehydrogenase complex catalyzes the overall conversion of
FCL41_11450	COG0567	Dehydrogenase, E1 component
FCL41_11475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FCL41_11495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FCL41_11505	COG0604	alcohol dehydrogenase
FCL41_11525	COG4974	Belongs to the 'phage' integrase family
FCL41_11660	COG1595	DNA-templated transcription, initiation
FCL41_11670	COG2135	peptidase activity
FCL41_11685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FCL41_11695	COG0483	inositol monophosphate 1-phosphatase activity
FCL41_11705	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FCL41_11715	COG2501	S4 domain
FCL41_11720	COG2733	membrane
FCL41_11725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FCL41_11735	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_11745	COG2205	protein histidine kinase activity
FCL41_11750	COG1605	Chorismate mutase
FCL41_11750	COG0287	Prephenate dehydrogenase
FCL41_11755	COG2030	dehydratase
FCL41_11760	COG1365	unkown
FCL41_11765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FCL41_11800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FCL41_11825	COG2357	RelA SpoT domain protein
FCL41_11830	COG1120	ATPase activity
FCL41_11845	COG2193	ferroxidase activity
FCL41_11860	COG2824	Alkylphosphonate utilization operon protein PhnA
FCL41_11895	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FCL41_11915	COG1615	UPF0182 protein
FCL41_11925	COG0750	zinc metalloprotease
FCL41_11955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FCL41_11955	COG1796	DNA polymerase
FCL41_11960	COG1024	Enoyl-CoA hydratase
FCL41_12000	COG2816	NAD+ diphosphatase activity
FCL41_12005	COG0813	purine-nucleoside phosphorylase activity
FCL41_12010	COG4585	Histidine kinase
FCL41_12015	COG2197	response regulator
FCL41_12020	COG0577	efflux transmembrane transporter activity
FCL41_12020	COG1136	(ABC) transporter
FCL41_12060	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_12060	COG0204	Acyl-transferase
FCL41_12095	COG1192	Involved in chromosome partitioning
FCL41_12100	COG0300	oxidoreductase activity
FCL41_12105	COG0613	PHP domain protein
FCL41_12120	COG1960	acyl-CoA dehydrogenase activity
FCL41_12160	COG2239	Acts as a magnesium transporter
FCL41_12175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FCL41_12200	COG0653	protein targeting
FCL41_12205	COG3214	Protein conserved in bacteria
FCL41_12210	COG2197	response regulator
FCL41_12215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FCL41_12225	COG5401	PFAM Sporulation and spore germination
FCL41_12230	COG5002	protein histidine kinase activity
FCL41_12230	COG5000	phosphorelay sensor kinase activity
FCL41_12235	COG0745	RESPONSE REGULATOR receiver
FCL41_12240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FCL41_12245	COG2354	Protein conserved in bacteria
FCL41_12255	COG2835	tetraacyldisaccharide 4'-kinase activity
FCL41_12295	COG0778	Nitroreductase
FCL41_12295	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FCL41_12305	COG0662	Cupin 2, conserved barrel domain protein
FCL41_12305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FCL41_12315	COG1131	(ABC) transporter
FCL41_12340	COG1216	Glycosyl transferase, family 2
FCL41_12355	COG1216	Glycosyl transferase, family 2
FCL41_12365	COG1316	TRANSCRIPTIONal
FCL41_12385	COG3304	Inner membrane component domain
FCL41_12425	COG0714	Associated with various cellular activities
FCL41_12435	COG1129	ABC transporter
FCL41_12465	COG1832	CoA-binding protein
FCL41_12475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FCL41_12485	COG0745	RESPONSE REGULATOR receiver
FCL41_12490	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FCL41_12505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FCL41_12520	COG0424	maF-like protein
FCL41_12530	COG1960	acyl-CoA dehydrogenase activity
FCL41_12535	COG4770	biotin carboxylase activity
FCL41_12550	COG2385	sporulation resulting in formation of a cellular spore
FCL41_12575	COG4129	membrane
FCL41_12610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FCL41_12615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FCL41_12620	COG4558	Periplasmic binding protein
FCL41_12630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FCL41_12635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL41_12645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FCL41_12650	COG1012	belongs to the aldehyde dehydrogenase family
FCL41_12655	COG1012	belongs to the aldehyde dehydrogenase family
FCL41_12690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FCL41_12730	COG1473	amidohydrolase
FCL41_12730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FCL41_12815	COG1674	ftsk spoiiie
FCL41_12860	COG1053	succinate dehydrogenase
FCL41_12865	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FCL41_12870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FCL41_12875	COG1116	anion transmembrane transporter activity
FCL41_12880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FCL41_12890	COG0180	Tryptophanyl-tRNA synthetase
FCL41_12900	COG1132	(ABC) transporter
FCL41_12905	COG2838	Isocitrate dehydrogenase
FCL41_12910	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FCL41_12925	COG0039	L-malate dehydrogenase activity
FCL41_12935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FCL41_12940	COG0138	bifunctional purine biosynthesis protein purh
FCL41_12965	COG0045	succinate-CoA ligase (ADP-forming) activity
FCL41_12970	COG0741	lytic transglycosylase activity
FCL41_12970	COG0739	heme binding
FCL41_12970	COG1196	nuclear chromosome segregation
FCL41_13005	COG2197	response regulator
FCL41_13025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_13035	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_13040	COG2072	flavoprotein involved in K transport
FCL41_13045	COG0385	Bile acid
FCL41_13050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FCL41_13055	COG4213	ABC transporter substrate-binding protein
FCL41_13065	COG0519	Catalyzes the synthesis of GMP from XMP
FCL41_13065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FCL41_13075	COG1012	belongs to the aldehyde dehydrogenase family
FCL41_13080	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FCL41_13105	COG0516	GMP reductase activity
FCL41_13120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL41_13130	COG0459	protein refolding
FCL41_13135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FCL41_13160	COG1595	DNA-templated transcription, initiation
FCL41_13170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FCL41_13180	COG1214	PFAM Peptidase M22, glycoprotease
FCL41_13180	COG0456	acetyltransferase
FCL41_13185	COG0802	atpase or kinase
FCL41_13195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FCL41_13210	COG0736	holo-[acyl-carrier-protein] synthase activity
FCL41_13215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FCL41_13220	COG1072	(Pantothenic acid kinase))
FCL41_13230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FCL41_13235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FCL41_13240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FCL41_13245	COG0372	Belongs to the citrate synthase family
FCL41_13250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FCL41_13265	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_13270	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_13295	COG2813	Specifically methylates the guanine in position
FCL41_13300	COG0101	tRNA pseudouridine synthase activity
FCL41_13305	COG0640	Transcriptional regulator
FCL41_13325	COG0203	ribosomal protein L17
FCL41_13330	COG0202	RNA polymerase activity
FCL41_13335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FCL41_13340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FCL41_13345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FCL41_13350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FCL41_13355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FCL41_13365	COG0563	adenylate kinase activity
FCL41_13375	COG0200	Binds to the 23S rRNA
FCL41_13380	COG1841	ribosomal large subunit assembly
FCL41_13385	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FCL41_13390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FCL41_13395	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FCL41_13400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FCL41_13405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FCL41_13410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FCL41_13415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FCL41_13420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FCL41_13425	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FCL41_13435	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FCL41_13440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FCL41_13445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FCL41_13450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FCL41_13455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FCL41_13460	COG0089	rRNA binding
FCL41_13465	COG0088	Forms part of the polypeptide exit tunnel
FCL41_13470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FCL41_13475	COG0051	transcription antitermination factor activity, RNA binding
FCL41_13495	COG0714	Associated with various cellular activities
FCL41_13515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FCL41_13525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FCL41_13530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FCL41_13535	COG0049	tRNA binding
FCL41_13540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FCL41_13545	COG2814	Major facilitator Superfamily
FCL41_13555	COG2252	PERMEase
FCL41_13570	COG1278	Cold shock
FCL41_13590	COG1061	Type III restriction enzyme res subunit
FCL41_13595	COG2188	Transcriptional regulator
FCL41_13600	COG0577	efflux transmembrane transporter activity
FCL41_13600	COG1136	(ABC) transporter
FCL41_13605	COG4591	ABC-type transport system involved in lipoprotein release permease component
FCL41_13605	COG1136	(ABC) transporter
FCL41_13630	COG1140	nitrate reductase beta subunit
FCL41_13650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FCL41_13660	COG0459	protein refolding
FCL41_13715	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FCL41_13725	COG2211	Major facilitator Superfamily
FCL41_13740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FCL41_13745	COG3384	dioxygenase
FCL41_13750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FCL41_13770	COG3265	gluconokinase activity
FCL41_13775	COG2610	gluconate transmembrane transporter activity
FCL41_13780	COG2409	Drug exporters of the RND superfamily
FCL41_13795	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FCL41_13800	COG0842	Transport permease protein
FCL41_13810	COG1131	(ABC) transporter
FCL41_13855	COG1914	H( )-stimulated, divalent metal cation uptake system
FCL41_13900	COG0745	RESPONSE REGULATOR receiver
FCL41_13905	COG5002	protein histidine kinase activity
FCL41_13915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL41_13930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FCL41_13950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FCL41_13960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FCL41_13960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FCL41_13965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FCL41_13970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FCL41_13980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FCL41_14000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FCL41_14010	COG1126	abc transporter atp-binding protein
FCL41_14015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FCL41_14020	COG0765	amino acid transport
FCL41_14025	COG0765	amino acid transport
FCL41_14035	COG1846	Transcriptional regulator
FCL41_14040	COG0488	(ABC) transporter
FCL41_14045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FCL41_14050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FCL41_14060	COG0084	hydrolase, TatD family'
FCL41_14090	COG1136	(ABC) transporter
FCL41_14095	COG0577	efflux transmembrane transporter activity
FCL41_14100	COG4085	toxin activity
FCL41_14100	COG0737	Belongs to the 5'-nucleotidase family
FCL41_14100	COG1525	nuclease
FCL41_14105	COG1329	Transcriptional regulator
FCL41_14135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL41_14140	COG0315	cyclic pyranopterin monophosphate synthase activity
FCL41_14140	COG0521	Mo-molybdopterin cofactor biosynthetic process
FCL41_14145	COG0315	cyclic pyranopterin monophosphate synthase activity
FCL41_14160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FCL41_14180	COG1970	mechanosensitive ion channel activity
FCL41_14195	COG3268	Saccharopine dehydrogenase
FCL41_14250	COG0477	Major facilitator Superfamily
FCL41_14265	COG2201	protein-glutamate methylesterase activity
FCL41_14280	COG2198	Histidine kinase
FCL41_14280	COG0643	Histidine kinase
FCL41_14285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FCL41_14290	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FCL41_14295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FCL41_14300	COG1256	bacterial-type flagellum assembly
FCL41_14300	COG4786	Flagellar basal body rod
FCL41_14310	COG1191	sigma factor activity
FCL41_14315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FCL41_14345	COG0745	RESPONSE REGULATOR receiver
FCL41_14355	COG1815	bacterial-type flagellum-dependent cell motility
FCL41_14360	COG1558	bacterial-type flagellum-dependent cell motility
FCL41_14365	COG1677	Flagellar hook-basal body complex protein FliE
FCL41_14370	COG1766	The M ring may be actively involved in energy transduction
FCL41_14375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FCL41_14385	COG1157	protein secretion by the type III secretion system
FCL41_14395	COG0741	lytic transglycosylase activity
FCL41_14410	COG4786	Flagellar basal body rod
FCL41_14420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FCL41_14435	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FCL41_14450	COG1338	Plays a role in the flagellum-specific transport system
FCL41_14455	COG1987	bacterial-type flagellum assembly
FCL41_14460	COG4791	protein targeting
FCL41_14470	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FCL41_14490	COG0259	pyridoxamine-phosphate oxidase activity
FCL41_14520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FCL41_14540	COG0277	FAD linked oxidase domain protein
FCL41_14540	COG0247	lactate metabolic process
FCL41_14555	COG0644	oxidoreductase
FCL41_14560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FCL41_14565	COG0085	RNA polymerase activity
FCL41_14570	COG0222	ribosome binding
FCL41_14575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FCL41_14580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FCL41_14585	COG0081	regulation of translation
FCL41_14590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FCL41_14610	COG0436	Aminotransferase
FCL41_14615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FCL41_14635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FCL41_14645	COG2030	dehydratase
FCL41_14650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FCL41_14665	COG0154	amidase activity
FCL41_14680	COG1346	cytolysis
FCL41_14690	COG0519	Catalyzes the synthesis of GMP from XMP
FCL41_14705	COG2814	Major facilitator Superfamily
FCL41_14715	COG0406	alpha-ribazole phosphatase activity
FCL41_14720	COG2197	response regulator
FCL41_14725	COG4585	Histidine kinase
FCL41_14735	COG1131	(ABC) transporter
FCL41_14750	COG1666	GTP binding
FCL41_14760	COG3842	ATPase activity
FCL41_14765	COG4208	sulfate ABC transporter
FCL41_14775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FCL41_14780	COG0674	pyruvate-flavodoxin oxidoreductase activity
FCL41_14780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FCL41_14785	COG1013	pyruvate-flavodoxin oxidoreductase activity
FCL41_14800	COG1007	ATP synthesis coupled electron transport
FCL41_14810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FCL41_14815	COG0713	ATP synthesis coupled electron transport
FCL41_14825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL41_14830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FCL41_14835	COG1034	ATP synthesis coupled electron transport
FCL41_14850	COG0649	NAD binding
FCL41_14855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL41_14860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FCL41_14870	COG2226	methyltransferase
FCL41_14880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FCL41_14895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FCL41_14900	COG4948	Mandelate Racemase Muconate Lactonizing
FCL41_14950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FCL41_14955	COG1333	cytochrome c biogenesis protein
FCL41_14960	COG0785	Cytochrome C biogenesis protein
FCL41_14970	COG0406	alpha-ribazole phosphatase activity
FCL41_14975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FCL41_14985	COG0113	porphobilinogen synthase activity
FCL41_14990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FCL41_14990	COG1648	precorrin-2 dehydrogenase activity
FCL41_14995	COG0181	hydroxymethylbilane synthase activity
FCL41_15000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FCL41_15005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FCL41_15015	COG0318	PFAM AMP-dependent synthetase and ligase
FCL41_15020	COG0560	Phosphoserine phosphatase
FCL41_15045	COG0123	including yeast histone deacetylase and acetoin utilization protein
FCL41_15050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FCL41_15070	COG1619	proteins homologs of microcin C7 resistance protein MccF
FCL41_15090	COG2226	methyltransferase
FCL41_15095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FCL41_15100	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FCL41_15115	COG0542	response to heat
FCL41_15140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FCL41_15150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FCL41_15155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FCL41_15160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FCL41_15180	COG1216	Glycosyl transferase, family 2
FCL41_15195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FCL41_15200	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FCL41_15205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FCL41_15210	COG0302	gtp cyclohydrolase
FCL41_15225	COG0037	tRNA processing
FCL41_15235	COG2027	D-alanyl-D-alanine carboxypeptidase
FCL41_15240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FCL41_15270	COG3842	ATPase activity
FCL41_15275	COG4149	molybdate abc transporter
FCL41_15295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FCL41_15305	COG1131	(ABC) transporter
FCL41_15340	COG2076	Multidrug Resistance protein
FCL41_15350	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FCL41_15385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FCL41_15390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FCL41_15395	COG2226	methyltransferase
FCL41_15410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FCL41_15410	COG1754	DNA topoisomerase type I activity
FCL41_15475	COG2890	protein-(glutamine-N5) methyltransferase activity
FCL41_15495	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FCL41_15500	COG1366	Belongs to the anti-sigma-factor antagonist family
FCL41_15505	COG1205	dead DEAH box helicase
FCL41_15505	COG1111	helicase
FCL41_15565	COG3275	phosphorelay sensor kinase activity
FCL41_15580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FCL41_15590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FCL41_15630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL41_15630	COG2146	nitrite reductase [NAD(P)H] activity
FCL41_15640	COG2378	regulation of single-species biofilm formation
FCL41_15645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FCL41_15645	COG2146	nitrite reductase [NAD(P)H] activity
FCL41_15650	COG0243	molybdopterin cofactor binding
FCL41_15655	COG2223	nitrite transmembrane transporter activity
FCL41_15665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FCL41_15670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_15700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FCL41_15730	COG2208	phosphoserine phosphatase activity
FCL41_15730	COG2770	Histidine kinase
FCL41_15735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FCL41_15750	COG0494	nUDIX hydrolase
FCL41_15755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FCL41_15770	COG1595	DNA-templated transcription, initiation
FCL41_15795	COG0251	oxidation-reduction process
FCL41_15815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FCL41_15860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FCL41_15905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FCL41_15910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FCL41_15950	COG1674	ftsk spoiiie
FCL41_15975	COG0542	response to heat
FCL41_16005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FCL41_16035	COG1074	ATP-dependent DNA helicase activity
FCL41_16040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FCL41_16060	COG3321	synthase
FCL41_16060	COG0604	alcohol dehydrogenase
FCL41_16065	COG3321	synthase
FCL41_16065	COG0604	alcohol dehydrogenase
FCL41_16065	COG1028	Short-chain dehydrogenase reductase Sdr
FCL41_16080	COG1819	glycosyl
FCL41_16090	COG0488	(ABC) transporter
FCL41_16095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FCL41_16100	COG0686	Belongs to the AlaDH PNT family
FCL41_16115	COG3483	tryptophan 2,3-dioxygenase activity
FCL41_16125	COG1136	(ABC) transporter
FCL41_16135	COG0076	glutamate decarboxylase activity
FCL41_16145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FCL41_16170	COG2205	protein histidine kinase activity
FCL41_16175	COG1960	acyl-CoA dehydrogenase activity
FCL41_16185	COG0189	ligase activity
FCL41_16205	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FCL41_16220	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FCL41_16225	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FCL41_16240	COG0590	tRNA wobble adenosine to inosine editing
FCL41_16265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FCL41_16270	COG3119	arylsulfatase activity
FCL41_16275	COG1937	Protein conserved in bacteria
FCL41_16285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FCL41_16285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FCL41_16300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FCL41_16335	COG0561	phosphatase activity
FCL41_16340	COG0561	phosphatase activity
FCL41_16345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FCL41_16360	COG1605	Chorismate mutase
FCL41_16360	COG0077	Prephenate dehydratase
FCL41_16390	COG1960	acyl-CoA dehydrogenase activity
FCL41_16405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FCL41_16405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FCL41_16430	COG0456	acetyltransferase
FCL41_16520	COG1595	DNA-templated transcription, initiation
FCL41_16535	COG3559	Exporter of polyketide antibiotics
FCL41_16540	COG1131	(ABC) transporter
FCL41_16545	COG1051	belongs to the nudix hydrolase family
FCL41_16550	COG1063	alcohol dehydrogenase
FCL41_16560	COG3119	arylsulfatase activity
FCL41_16565	COG1595	DNA-templated transcription, initiation
FCL41_16595	COG0305	Participates in initiation and elongation during chromosome replication
FCL41_16600	COG0534	Mate efflux family protein
FCL41_16605	COG0359	binds to the 23S rRNA
FCL41_16610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FCL41_16615	COG0629	single-stranded DNA binding
FCL41_16620	COG0360	Binds together with S18 to 16S ribosomal RNA
FCL41_16625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FCL41_16725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FCL41_16735	COG1260	myo-inositol-1-phosphate synthase
FCL41_16760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FCL41_16765	COG0617	tRNA 3'-terminal CCA addition
FCL41_16785	COG1595	DNA-templated transcription, initiation
FCL41_16800	COG3118	belongs to the thioredoxin family
FCL41_16810	COG0436	Aminotransferase
FCL41_16815	COG0204	Acyl-transferase
FCL41_16825	COG1192	Involved in chromosome partitioning
FCL41_16830	COG0357	Ribosomal RNA small subunit methyltransferase G
FCL41_16840	COG0706	membrane insertase activity
FCL41_16845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FCL41_16850	COG0594	ribonuclease P activity
FCL41_16855	COG0230	Belongs to the bacterial ribosomal protein bL34 family