locus-tag	class	description
A8A54_00020	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_00045	COG0346	lactoylglutathione lyase activity
A8A54_00050	COG0489	protein tyrosine kinase activity
A8A54_00055	COG0033	Phosphoglucomutase
A8A54_00060	COG1072	(Pantothenic acid kinase))
A8A54_00090	COG1272	protein, Hemolysin III
A8A54_00100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8A54_00120	COG1846	Transcriptional regulator
A8A54_00130	COG0024	Methionine aminopeptidase
A8A54_00140	COG0137	argininosuccinate synthase activity
A8A54_00145	COG0500	methyltransferase
A8A54_00160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8A54_00170	COG3339	Conserved Protein
A8A54_00180	COG2154	pterin-4-alpha-carbinolamine dehydratase
A8A54_00200	COG4181	ATPase activity
A8A54_00210	COG0670	Belongs to the BI1 family
A8A54_00230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8A54_00240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8A54_00245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A8A54_00255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8A54_00260	COG0129	dihydroxy-acid dehydratase activity
A8A54_00280	COG2199	diguanylate cyclase activity
A8A54_00300	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A8A54_00305	COG4208	sulfate ABC transporter
A8A54_00310	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A8A54_00315	COG3459	Glycosyltransferase 36 associated
A8A54_00320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8A54_00325	COG0384	phenazine biosynthesis protein PhzF
A8A54_00330	COG2226	methyltransferase
A8A54_00340	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_00345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8A54_00360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8A54_00365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8A54_00375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8A54_00375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8A54_00390	COG0187	DNA topoisomerase II activity
A8A54_00395	COG2124	cytochrome p450
A8A54_00405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A8A54_00415	COG2153	protein acetylation
A8A54_00435	COG1643	Atp-dependent helicase
A8A54_00450	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A8A54_00460	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_00460	COG1388	LysM domain
A8A54_00465	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8A54_00475	COG0180	Tryptophanyl-tRNA synthetase
A8A54_00480	COG0728	peptidoglycan biosynthetic process
A8A54_00485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A8A54_00490	COG0281	malic enzyme
A8A54_00490	COG0280	phosphate acetyltransferase
A8A54_00495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8A54_00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8A54_00515	COG0116	Belongs to the methyltransferase superfamily
A8A54_00515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A8A54_00530	COG0616	signal peptide processing
A8A54_00540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A8A54_00545	COG1137	ATPase activity
A8A54_00550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A8A54_00555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A8A54_00560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8A54_00570	COG0071	Belongs to the small heat shock protein (HSP20) family
A8A54_00590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_00595	COG2860	membrane
A8A54_00600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8A54_00610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A8A54_00620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8A54_00625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8A54_00630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8A54_00640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8A54_00640	COG1648	precorrin-2 dehydrogenase activity
A8A54_00650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8A54_00655	COG0175	sulfate reduction
A8A54_00670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8A54_00690	COG2197	response regulator
A8A54_00700	COG0175	sulfate reduction
A8A54_00725	COG2197	response regulator
A8A54_00755	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_00770	COG1609	Transcriptional regulator
A8A54_00775	COG5265	(ABC) transporter
A8A54_00780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_00785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A8A54_00790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8A54_00815	COG0351	phosphomethylpyrimidine kinase
A8A54_00820	COG5001	Diguanylate cyclase
A8A54_00835	COG0789	Transcriptional regulator
A8A54_00840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8A54_00860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8A54_00860	COG0446	pyridine nucleotide-disulphide oxidoreductase
A8A54_00870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8A54_00895	COG1175	transmembrane transport
A8A54_00900	COG0395	ABC-type sugar transport system, permease component
A8A54_00905	COG3842	ATPase activity
A8A54_00910	COG4948	Mandelate Racemase Muconate Lactonizing
A8A54_00915	COG3254	rhamnose metabolic process
A8A54_00930	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_00940	COG4948	Mandelate Racemase Muconate Lactonizing
A8A54_00950	COG5001	Diguanylate cyclase
A8A54_00955	COG0778	Nitroreductase
A8A54_00965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A8A54_00975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8A54_00980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8A54_00985	COG5328	Belongs to the UPF0262 family
A8A54_01025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8A54_01030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8A54_01035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8A54_01040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_01045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_01065	COG1309	transcriptional regulator
A8A54_01070	COG0494	nUDIX hydrolase
A8A54_01075	COG3842	ATPase activity
A8A54_01080	COG0395	ABC-type sugar transport system, permease component
A8A54_01100	COG2186	Transcriptional regulator
A8A54_01110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_01115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8A54_01130	COG1175	transmembrane transport
A8A54_01135	COG0395	ABC-type sugar transport system, permease component
A8A54_01140	COG3842	ATPase activity
A8A54_01150	COG0493	'glutamate synthase
A8A54_01155	COG0697	spore germination
A8A54_01165	COG0166	Belongs to the GPI family
A8A54_01175	COG0546	phosphoglycolate phosphatase activity
A8A54_01185	COG0318	PFAM AMP-dependent synthetase and ligase
A8A54_01215	COG2326	polyphosphate kinase activity
A8A54_01220	COG5002	protein histidine kinase activity
A8A54_01230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8A54_01240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A8A54_01245	COG2967	ApaG domain
A8A54_01275	COG0534	Mate efflux family protein
A8A54_01280	COG0167	dihydroorotate dehydrogenase activity
A8A54_01295	COG0784	Response regulator, receiver
A8A54_01295	COG2205	protein histidine kinase activity
A8A54_01320	COG2378	regulation of single-species biofilm formation
A8A54_01330	COG0156	8-amino-7-oxononanoate synthase activity
A8A54_01335	COG0726	polysaccharide deacetylase
A8A54_01345	COG1442	glycosyl transferase family 8
A8A54_01355	COG0583	DNA-binding transcription factor activity
A8A54_01360	COG1380	Effector of murein hydrolase LrgA
A8A54_01370	COG0346	lactoylglutathione lyase activity
A8A54_01375	COG0346	lactoylglutathione lyase activity
A8A54_01385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8A54_01395	COG1309	transcriptional regulator
A8A54_01405	COG0110	maltose O-acetyltransferase activity
A8A54_01425	COG0019	diaminopimelate decarboxylase activity
A8A54_01435	COG3938	Belongs to the proline racemase family
A8A54_01440	COG0534	Mate efflux family protein
A8A54_01455	COG3257	ureidoglycine aminohydrolase activity
A8A54_01465	COG2351	hydroxyisourate hydrolase activity
A8A54_01475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A8A54_01495	COG0402	S-adenosylhomocysteine deaminase activity
A8A54_01500	COG1414	Transcriptional regulator
A8A54_01505	COG3960	tartronate-semialdehyde synthase activity
A8A54_01510	COG3622	Belongs to the hyi family
A8A54_01515	COG2084	Dehydrogenase
A8A54_01565	COG0735	belongs to the Fur family
A8A54_01570	COG0642	Histidine kinase
A8A54_01575	COG0745	RESPONSE REGULATOR receiver
A8A54_01585	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_01590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8A54_01590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8A54_01595	COG2169	Transcriptional regulator
A8A54_01595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8A54_01605	COG1393	Belongs to the ArsC family
A8A54_01615	COG0477	Major facilitator Superfamily
A8A54_01620	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A8A54_01635	COG1160	GTP binding
A8A54_01665	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_01675	COG1230	cation diffusion facilitator family transporter
A8A54_01680	COG0443	Heat shock 70 kDa protein
A8A54_01715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8A54_01720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8A54_01725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8A54_01730	COG1522	sequence-specific DNA binding
A8A54_01735	COG1280	lysine exporter protein (LysE YggA)
A8A54_01780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8A54_01805	COG0142	geranyltranstransferase activity
A8A54_01820	COG0751	glycine-tRNA ligase activity
A8A54_01825	COG0009	L-threonylcarbamoyladenylate synthase
A8A54_01840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A8A54_01845	COG1960	acyl-CoA dehydrogenase activity
A8A54_01860	COG3706	GGDEF domain
A8A54_01870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A8A54_01880	COG2755	lipolytic protein G-D-S-L family
A8A54_01880	COG0657	acetylesterase activity
A8A54_01890	COG0484	heat shock protein binding
A8A54_01895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8A54_01930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8A54_01930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8A54_01935	COG0123	including yeast histone deacetylase and acetoin utilization protein
A8A54_01940	COG1722	exodeoxyribonuclease VII activity
A8A54_01945	COG0586	Pfam SNARE associated Golgi protein
A8A54_01950	COG2261	transglycosylase associated protein
A8A54_01960	COG1741	Belongs to the pirin family
A8A54_01965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8A54_01990	COG1794	racemase activity, acting on amino acids and derivatives
A8A54_02005	COG1652	LysM domain
A8A54_02015	COG5265	(ABC) transporter
A8A54_02020	COG0688	phosphatidylethanolamine metabolic process
A8A54_02025	COG1183	phosphatidylcholine synthase activity
A8A54_02035	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_02040	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A8A54_02055	COG0305	Participates in initiation and elongation during chromosome replication
A8A54_02065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8A54_02070	COG0359	binds to the 23S rRNA
A8A54_02080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8A54_02085	COG0360	Binds together with S18 to 16S ribosomal RNA
A8A54_02090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8A54_02105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8A54_02110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8A54_02115	COG1561	YicC-like family, N-terminal region
A8A54_02125	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_02150	COG0312	modulator of DNA gyrase
A8A54_02165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8A54_02180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A8A54_02195	COG3346	SURF1 family
A8A54_02200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8A54_02205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A8A54_02225	COG0678	peroxiredoxin activity
A8A54_02240	COG1678	Uncharacterized ACR, COG1678
A8A54_02250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8A54_02255	COG0612	Peptidase, M16
A8A54_02270	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8A54_02290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A8A54_02330	COG1196	nuclear chromosome segregation
A8A54_02350	COG0456	acetyltransferase
A8A54_02355	COG0574	Belongs to the PEP-utilizing enzyme family
A8A54_02355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8A54_02380	COG1268	BioY protein
A8A54_02390	COG2351	hydroxyisourate hydrolase activity
A8A54_02400	COG4977	sequence-specific DNA binding
A8A54_02405	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_02410	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A8A54_02415	COG1309	transcriptional regulator
A8A54_02420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8A54_02430	COG2186	Transcriptional regulator
A8A54_02435	COG2807	transmembrane transport
A8A54_02445	COG0433	COG0433 Predicted ATPase
A8A54_02450	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_02460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8A54_02465	COG3909	cytochrome
A8A54_02470	COG2010	Cytochrome c
A8A54_02490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8A54_02515	COG0154	amidase activity
A8A54_02520	COG2166	iron-sulfur cluster assembly
A8A54_02530	COG2205	protein histidine kinase activity
A8A54_02560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8A54_02575	COG4695	Portal protein
A8A54_02655	COG0745	RESPONSE REGULATOR receiver
A8A54_02660	COG2205	protein histidine kinase activity
A8A54_02670	COG4235	cytochrome complex assembly
A8A54_02675	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A8A54_02680	COG1138	Cytochrome C-type biogenesis protein
A8A54_02685	COG3088	subunit of a heme lyase
A8A54_02690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8A54_02695	COG0745	RESPONSE REGULATOR receiver
A8A54_02700	COG2205	protein histidine kinase activity
A8A54_02705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A8A54_02710	COG2205	protein histidine kinase activity
A8A54_02710	COG2202	Pas domain
A8A54_02715	COG0308	aminopeptidase N
A8A54_02730	COG1573	uracil-dna glycosylase
A8A54_02745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8A54_02750	COG0625	glutathione transferase activity
A8A54_02785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8A54_02815	COG0052	Belongs to the universal ribosomal protein uS2 family
A8A54_02820	COG0741	lytic transglycosylase activity
A8A54_02840	COG1758	RNA polymerase activity
A8A54_02855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8A54_02860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8A54_02865	COG2223	nitrite transmembrane transporter activity
A8A54_02870	COG2207	Transcriptional regulator
A8A54_02885	COG0681	Belongs to the peptidase S26 family
A8A54_02910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A8A54_02920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8A54_02945	COG0494	nUDIX hydrolase
A8A54_02970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8A54_02980	COG0739	heme binding
A8A54_02985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8A54_02990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8A54_02995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8A54_03000	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A8A54_03015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8A54_03030	COG0488	(ABC) transporter
A8A54_03040	COG0105	UTP biosynthetic process
A8A54_03050	COG0314	molybdopterin synthase activity
A8A54_03055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A8A54_03060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A8A54_03070	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_03095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A8A54_03105	COG0243	molybdopterin cofactor binding
A8A54_03115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A8A54_03120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A8A54_03125	COG0628	permease
A8A54_03145	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_03180	COG0626	cystathionine gamma-synthase activity
A8A54_03185	COG0671	phosphoesterase, PA-phosphatase related
A8A54_03190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_03195	COG4597	amino acid ABC transporter
A8A54_03200	COG0765	amino acid transport
A8A54_03205	COG1126	abc transporter atp-binding protein
A8A54_03220	COG0640	Transcriptional regulator
A8A54_03230	COG1733	regulation of RNA biosynthetic process
A8A54_03255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8A54_03265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A8A54_03270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8A54_03280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8A54_03295	COG0113	porphobilinogen synthase activity
A8A54_03315	COG2989	Protein conserved in bacteria
A8A54_03320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8A54_03325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A8A54_03330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8A54_03330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8A54_03340	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8A54_03345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8A54_03350	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A8A54_03355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8A54_03370	COG0416	fatty acid biosynthetic process
A8A54_03375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8A54_03390	COG2076	Multidrug Resistance protein
A8A54_03395	COG0356	it plays a direct role in the translocation of protons across the membrane
A8A54_03420	COG1742	UPF0060 membrane protein
A8A54_03430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8A54_03435	COG0438	transferase activity, transferring glycosyl groups
A8A54_03460	COG1612	heme a metabolic process
A8A54_03470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8A54_03475	COG0010	Belongs to the arginase family
A8A54_03480	COG2329	Antibiotic biosynthesis monooxygenase
A8A54_03485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8A54_03500	COG1832	CoA-binding protein
A8A54_03515	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_03540	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_03550	COG1879	ABC-type sugar transport system periplasmic component
A8A54_03555	COG1349	DNA-binding transcription factor activity
A8A54_03580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8A54_03590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8A54_03595	COG0649	NAD binding
A8A54_03600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A8A54_03605	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A8A54_03615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8A54_03620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8A54_03630	COG0713	ATP synthesis coupled electron transport
A8A54_03645	COG1007	ATP synthesis coupled electron transport
A8A54_03675	COG0442	prolyl-tRNA aminoacylation
A8A54_03695	COG0587	DNA-directed DNA polymerase activity
A8A54_03705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8A54_03710	COG1733	regulation of RNA biosynthetic process
A8A54_03730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8A54_03735	COG0037	tRNA processing
A8A54_03740	COG0483	inositol monophosphate 1-phosphatase activity
A8A54_03745	COG2814	Major facilitator Superfamily
A8A54_03760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8A54_03765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8A54_03790	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8A54_03815	COG2514	catechol 2,3-dioxygenase activity
A8A54_03825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A8A54_03845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8A54_03850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8A54_03855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8A54_03870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_03875	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A8A54_03880	COG3454	Phosphonate metabolism
A8A54_03885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8A54_03890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8A54_03905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A8A54_03910	COG1522	sequence-specific DNA binding
A8A54_03940	COG0316	Belongs to the HesB IscA family
A8A54_03945	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8A54_03950	COG0018	arginyl-trna synthetase
A8A54_03960	COG1472	Belongs to the glycosyl hydrolase 3 family
A8A54_03965	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8A54_03970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A8A54_03975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8A54_03980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8A54_03985	COG0805	protein transport
A8A54_03995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A8A54_04000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8A54_04035	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A8A54_04060	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8A54_04085	COG4765	Protein conserved in bacteria
A8A54_04090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A8A54_04095	COG0439	Biotin carboxylase
A8A54_04100	COG0511	ligase activity, forming carbon-carbon bonds
A8A54_04115	COG0501	Belongs to the peptidase M48B family
A8A54_04120	COG0436	Aminotransferase
A8A54_04125	COG1530	ribonuclease E activity
A8A54_04135	COG0860	N-Acetylmuramoyl-L-alanine amidase
A8A54_04140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8A54_04155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8A54_04175	COG2945	thiolester hydrolase activity
A8A54_04185	COG0719	Fe-S assembly protein
A8A54_04190	COG0396	ATPase activity
A8A54_04195	COG0719	Fe-S assembly protein
A8A54_04200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8A54_04205	COG2151	metal-sulfur cluster biosynthetic enzyme
A8A54_04225	COG0513	Belongs to the DEAD box helicase family
A8A54_04235	COG0316	Belongs to the HesB IscA family
A8A54_04250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8A54_04275	COG2084	Dehydrogenase
A8A54_04280	COG0625	glutathione transferase activity
A8A54_04295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_04325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A8A54_04325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A8A54_04330	COG2989	Protein conserved in bacteria
A8A54_04340	COG0095	Lipoate-protein ligase
A8A54_04345	COG0488	(ABC) transporter
A8A54_04355	COG1464	Belongs to the NlpA lipoprotein family
A8A54_04540	COG0330	HflC and HflK could
A8A54_04555	COG2259	Doxx family
A8A54_04570	COG1597	lipid kinase activity
A8A54_04600	COG0084	hydrolase, TatD family'
A8A54_04605	COG0321	lipoyl(octanoyl) transferase activity
A8A54_04605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8A54_04635	COG0174	glutamine synthetase
A8A54_04640	COG0347	Belongs to the P(II) protein family
A8A54_04645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A8A54_04645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8A54_04650	COG0546	phosphoglycolate phosphatase activity
A8A54_04670	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A8A54_04685	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A8A54_04685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8A54_04690	COG0280	phosphate acetyltransferase
A8A54_04690	COG0281	malic enzyme
A8A54_04695	COG0372	Belongs to the citrate synthase family
A8A54_04710	COG4948	Mandelate Racemase Muconate Lactonizing
A8A54_04715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8A54_04720	COG1127	ABC transporter
A8A54_04740	COG0633	Ferredoxin
A8A54_04745	COG0492	ferredoxin-NADP+ reductase activity
A8A54_04745	COG0492	ferredoxin-NADP+ reductase activity
A8A54_04755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8A54_04765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A8A54_04775	COG3768	UPF0283 membrane protein
A8A54_04780	COG3106	COG3106 Predicted ATPase
A8A54_04790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A8A54_04815	COG0668	transmembrane transport
A8A54_04825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8A54_04845	COG1058	Belongs to the CinA family
A8A54_04845	COG1546	Belongs to the CinA family
A8A54_04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8A54_04860	COG0513	Belongs to the DEAD box helicase family
A8A54_04865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8A54_04870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8A54_04875	COG2897	thiosulfate sulfurtransferase activity
A8A54_04885	COG3706	GGDEF domain
A8A54_04890	COG0427	acetyl-CoA hydrolase
A8A54_04900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8A54_04905	COG0385	Bile acid
A8A54_04910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8A54_04915	COG3956	TIGRFAM MazG family protein
A8A54_04955	COG0302	gtp cyclohydrolase
A8A54_04960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8A54_04965	COG1752	Esterase of the alpha-beta hydrolase superfamily
A8A54_04980	COG3585	molybdate ion transport
A8A54_04990	COG1960	acyl-CoA dehydrogenase activity
A8A54_04995	COG0583	DNA-binding transcription factor activity
A8A54_05000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8A54_05005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8A54_05010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8A54_05020	COG0343	queuine tRNA-ribosyltransferase activity
A8A54_05025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8A54_05030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8A54_05035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8A54_05040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8A54_05045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8A54_05050	COG2095	MarC family integral membrane protein
A8A54_05055	COG3639	organic phosphonate transmembrane transporter activity
A8A54_05060	COG3639	organic phosphonate transmembrane transporter activity
A8A54_05065	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A8A54_05070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A8A54_05080	COG3454	Phosphonate metabolism
A8A54_05090	COG4778	phosphonate C-P lyase system protein PhnL
A8A54_05095	COG4107	phosphonate C-P lyase system protein PhnK
A8A54_05100	COG3627	carbon phosphorus lyase activity
A8A54_05105	COG3626	phosphonate metabolism
A8A54_05115	COG3624	Phosphonate C-P lyase system protein PhnG
A8A54_05120	COG2188	Transcriptional regulator
A8A54_05125	COG1393	Belongs to the ArsC family
A8A54_05135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8A54_05140	COG3698	Phosphodiester glycosidase
A8A54_05155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8A54_05165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8A54_05180	COG0569	domain protein
A8A54_05185	COG2204	response regulator
A8A54_05190	COG5000	phosphorelay sensor kinase activity
A8A54_05195	COG2204	response regulator
A8A54_05200	COG3852	Histidine kinase
A8A54_05210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A8A54_05210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8A54_05215	COG1546	Belongs to the CinA family
A8A54_05215	COG1058	Belongs to the CinA family
A8A54_05220	COG2867	negative regulation of translational initiation
A8A54_05225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8A54_05235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8A54_05245	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8A54_05250	COG0022	dehydrogenase e1 component
A8A54_05250	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8A54_05255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8A54_05260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A8A54_05265	COG5507	3-demethylubiquinone-9 3-methyltransferase
A8A54_05270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8A54_05275	COG0148	phosphopyruvate hydratase activity
A8A54_05280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8A54_05290	COG0504	CTP synthase activity
A8A54_05315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8A54_05320	COG0134	indole-3-glycerol-phosphate synthase activity
A8A54_05325	COG0315	cyclic pyranopterin monophosphate synthase activity
A8A54_05335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A8A54_05350	COG0372	Belongs to the citrate synthase family
A8A54_05355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8A54_05380	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8A54_05405	COG0528	UMP kinase activity
A8A54_05410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8A54_05415	COG0052	Belongs to the universal ribosomal protein uS2 family
A8A54_05430	COG0584	glycerophosphoryl diester phosphodiesterase
A8A54_05440	COG0537	adenosine 5'-monophosphoramidase activity
A8A54_05465	COG1686	Belongs to the peptidase S11 family
A8A54_05480	COG1760	l-serine dehydratase
A8A54_05515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A8A54_05525	COG1396	sequence-specific DNA binding
A8A54_05525	COG3800	Transcriptional regulator
A8A54_05530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8A54_05535	COG0439	Biotin carboxylase
A8A54_05560	COG0656	L-ascorbic acid biosynthetic process
A8A54_05565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8A54_05575	COG0693	protein deglycase activity
A8A54_05585	COG0538	isocitrate dehydrogenase activity
A8A54_05620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8A54_05625	COG2885	chlorophyll binding
A8A54_05640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8A54_05650	COG0203	ribosomal protein L17
A8A54_05655	COG0202	RNA polymerase activity
A8A54_05665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8A54_05670	COG0563	adenylate kinase activity
A8A54_05680	COG0200	Binds to the 23S rRNA
A8A54_05690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8A54_05695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8A54_05705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8A54_05710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8A54_05715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8A54_05720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8A54_05725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8A54_05730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8A54_05740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8A54_05760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8A54_05770	COG0088	Forms part of the polypeptide exit tunnel
A8A54_05775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8A54_05790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8A54_05815	COG0085	RNA polymerase activity
A8A54_05820	COG0222	ribosome binding
A8A54_05825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8A54_05830	COG0081	regulation of translation
A8A54_05835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8A54_05870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8A54_05875	COG0516	GMP reductase activity
A8A54_05875	COG0517	IMP dehydrogenase activity
A8A54_05930	COG1278	Cold shock
A8A54_05935	COG0346	lactoylglutathione lyase activity
A8A54_05945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8A54_05950	COG1494	fructose-1,6-bisphosphatase
A8A54_05955	COG0488	(ABC) transporter
A8A54_05965	COG0436	Aminotransferase
A8A54_06000	COG0024	Methionine aminopeptidase
A8A54_06005	COG2003	Belongs to the UPF0758 family
A8A54_06020	COG0747	negative chemotaxis
A8A54_06025	COG0601	transmembrane transport
A8A54_06040	COG4608	Belongs to the ABC transporter superfamily
A8A54_06045	COG2375	cellular response to nickel ion
A8A54_06085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8A54_06095	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A8A54_06105	COG1797	cobyrinic acid a,c-diamide synthase activity
A8A54_06115	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A8A54_06120	COG2099	Precorrin-6x reductase
A8A54_06130	COG1309	transcriptional regulator
A8A54_06190	COG1492	cobalamin metabolic process
A8A54_06205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A8A54_06215	COG0583	DNA-binding transcription factor activity
A8A54_06230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8A54_06240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A8A54_06240	COG3264	Mechanosensitive ion channel
A8A54_06255	COG4651	solute:proton antiporter activity
A8A54_06255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8A54_06270	COG4208	sulfate ABC transporter
A8A54_06275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A8A54_06280	COG4150	thiosulfate binding
A8A54_06290	COG1253	flavin adenine dinucleotide binding
A8A54_06295	COG0586	Pfam SNARE associated Golgi protein
A8A54_06315	COG4154	Belongs to the RbsD FucU family
A8A54_06325	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_06335	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_06345	COG0673	inositol 2-dehydrogenase activity
A8A54_06350	COG1120	ATPase activity
A8A54_06365	COG4206	TonB-dependent receptor
A8A54_06370	COG0842	Transport permease protein
A8A54_06375	COG1129	ABC transporter
A8A54_06375	COG0842	Transport permease protein
A8A54_06380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8A54_06400	COG0384	phenazine biosynthesis protein PhzF
A8A54_06420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8A54_06425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8A54_06435	COG3158	transport of potassium into the cell
A8A54_06440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A8A54_06450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8A54_06460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A8A54_06480	COG0028	Belongs to the TPP enzyme family
A8A54_06490	COG0560	Phosphoserine phosphatase
A8A54_06500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8A54_06510	COG0330	HflC and HflK could
A8A54_06525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8A54_06540	COG2814	Major facilitator Superfamily
A8A54_06575	COG0277	FAD linked oxidase domain protein
A8A54_06590	COG0210	DNA helicase
A8A54_06605	COG1999	signal sequence binding
A8A54_06635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8A54_06645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8A54_06655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8A54_06660	COG0849	cell division
A8A54_06665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8A54_06670	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8A54_06680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8A54_06685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8A54_06695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8A54_06700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8A54_06725	COG0275	rRNA processing
A8A54_06730	COG1914	H( )-stimulated, divalent metal cation uptake system
A8A54_06735	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_06750	COG3023	N-Acetylmuramoyl-L-alanine amidase
A8A54_06755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A8A54_06775	COG4106	trans-aconitate 2-methyltransferase activity
A8A54_06800	COG2226	methyltransferase
A8A54_06810	COG0477	Major facilitator Superfamily
A8A54_06815	COG4106	trans-aconitate 2-methyltransferase activity
A8A54_06825	COG2267	carboxylic ester hydrolase activity
A8A54_06830	COG0463	Glycosyl transferase, family 2
A8A54_06840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8A54_06855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8A54_06860	COG2824	Alkylphosphonate utilization operon protein PhnA
A8A54_06865	COG1335	isochorismatase
A8A54_06910	COG3237	CsbD-like
A8A54_06920	COG2234	aminopeptidase activity
A8A54_06930	COG2968	Membrane
A8A54_06955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8A54_06960	COG0358	DNA primase activity
A8A54_06975	COG0505	Belongs to the CarA family
A8A54_06980	COG2321	neutral zinc metallopeptidase
A8A54_06995	COG1278	Cold shock
A8A54_07010	COG1309	transcriptional regulator
A8A54_07015	COG0625	glutathione transferase activity
A8A54_07035	COG1175	transmembrane transport
A8A54_07040	COG3833	ABC-type maltose transport systems, permease component
A8A54_07045	COG1653	transport
A8A54_07050	COG0583	DNA-binding transcription factor activity
A8A54_07055	COG0492	ferredoxin-NADP+ reductase activity
A8A54_07060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A8A54_07065	COG1522	sequence-specific DNA binding
A8A54_07100	COG1607	acyl-coa hydrolase
A8A54_07110	COG0556	nucleotide-excision repair
A8A54_07120	COG1733	regulation of RNA biosynthetic process
A8A54_07125	COG0739	heme binding
A8A54_07125	COG0741	lytic transglycosylase activity
A8A54_07125	COG1196	nuclear chromosome segregation
A8A54_07130	COG1278	Cold shock
A8A54_07140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8A54_07155	COG1846	Transcriptional regulator
A8A54_07160	COG0745	RESPONSE REGULATOR receiver
A8A54_07165	COG2205	protein histidine kinase activity
A8A54_07170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8A54_07175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8A54_07190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8A54_07215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8A54_07240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8A54_07245	COG0012	GTP binding
A8A54_07250	COG2030	dehydratase
A8A54_07260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A8A54_07265	COG2857	Cytochrome c1
A8A54_07265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A8A54_07280	COG1132	(ABC) transporter
A8A54_07285	COG1132	(ABC) transporter
A8A54_07290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A8A54_07305	COG0408	coproporphyrinogen oxidase activity
A8A54_07315	COG3811	Belongs to the UPF0386 family
A8A54_07330	COG0617	tRNA 3'-terminal CCA addition
A8A54_07335	COG0494	nUDIX hydrolase
A8A54_07345	COG0714	Associated with various cellular activities
A8A54_07370	COG0435	Glutathione S-transferase
A8A54_07375	COG3047	cAMP biosynthetic process
A8A54_07380	COG0494	nUDIX hydrolase
A8A54_07400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A8A54_07405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8A54_07405	COG0512	Glutamine amidotransferase of anthranilate synthase
A8A54_07450	COG4176	ABC-type proline glycine betaine transport system permease component
A8A54_07455	COG4175	Glycine betaine
A8A54_07460	COG4608	Belongs to the ABC transporter superfamily
A8A54_07470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_07475	COG0601	transmembrane transport
A8A54_07480	COG0747	negative chemotaxis
A8A54_07495	COG0482	sulfurtransferase activity
A8A54_07525	COG0745	RESPONSE REGULATOR receiver
A8A54_07535	COG2378	regulation of single-species biofilm formation
A8A54_07545	COG3180	Ammonia monooxygenase
A8A54_07615	COG1902	pentaerythritol trinitrate reductase activity
A8A54_07620	COG0640	Transcriptional regulator
A8A54_07625	COG2183	response to ionizing radiation
A8A54_07630	COG3842	ATPase activity
A8A54_07640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A8A54_07645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_07650	COG0583	DNA-binding transcription factor activity
A8A54_07655	COG5383	Protein conserved in bacteria
A8A54_07660	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8A54_07695	COG0243	molybdopterin cofactor binding
A8A54_07700	COG1304	FMN binding
A8A54_07710	COG1522	sequence-specific DNA binding
A8A54_07720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_07760	COG1228	amidohydrolase
A8A54_07765	COG2986	histidine ammonia-lyase
A8A54_07775	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A8A54_07795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_07810	COG4214	carbohydrate transport
A8A54_07820	COG4213	ABC transporter substrate-binding protein
A8A54_07825	COG0800	Aldolase
A8A54_07830	COG3734	2-keto-3-deoxy-galactonokinase
A8A54_07835	COG0129	dihydroxy-acid dehydratase activity
A8A54_07850	COG1879	ABC-type sugar transport system periplasmic component
A8A54_07855	COG1129	ABC transporter
A8A54_07860	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_07865	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_07870	COG2186	Transcriptional regulator
A8A54_07890	COG0183	Belongs to the thiolase family
A8A54_07900	COG0028	Belongs to the TPP enzyme family
A8A54_07920	COG0410	ABC transporter
A8A54_07925	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8A54_07950	COG2011	ABC-type metal ion transport system permease component
A8A54_07965	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8A54_07980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8A54_07990	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A8A54_07995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8A54_08000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A8A54_08020	COG5001	Diguanylate cyclase
A8A54_08030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8A54_08035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8A54_08040	COG1609	Transcriptional regulator
A8A54_08045	COG1846	Transcriptional regulator
A8A54_08055	COG0523	cobalamin synthesis protein
A8A54_08065	COG0400	carboxylic ester hydrolase activity
A8A54_08070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A8A54_08085	COG0251	oxidation-reduction process
A8A54_08095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A8A54_08100	COG0594	ribonuclease P activity
A8A54_08130	COG3739	integral membrane protein
A8A54_08140	COG2171	N-acyltransferase activity
A8A54_08160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8A54_08180	COG0101	tRNA pseudouridine synthase activity
A8A54_08185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8A54_08190	COG0242	peptide deformylase activity
A8A54_08205	COG0481	GTPase activity
A8A54_08220	COG1968	undecaprenyl-diphosphatase activity
A8A54_08230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8A54_08240	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A8A54_08255	COG1132	(ABC) transporter
A8A54_08265	COG0588	phosphoglycerate mutase activity
A8A54_08300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8A54_08310	COG1595	DNA-templated transcription, initiation
A8A54_08315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8A54_08325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A8A54_08330	COG2226	methyltransferase
A8A54_08335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8A54_08340	COG2900	Belongs to the SlyX family
A8A54_08350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8A54_08415	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_08440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8A54_08445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A8A54_08455	COG0456	acetyltransferase
A8A54_08465	COG0659	secondary active sulfate transmembrane transporter activity
A8A54_08470	COG0477	Major facilitator Superfamily
A8A54_08490	COG1522	sequence-specific DNA binding
A8A54_08495	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_08505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8A54_08510	COG4591	ABC-type transport system involved in lipoprotein release permease component
A8A54_08510	COG1136	(ABC) transporter
A8A54_08520	COG0848	biopolymer transport protein
A8A54_08540	COG3920	Histidine kinase
A8A54_08555	COG0784	Response regulator, receiver
A8A54_08590	COG0564	pseudouridine synthase activity
A8A54_08595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8A54_08600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8A54_08620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8A54_08630	COG0385	Bile acid
A8A54_08640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8A54_08645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8A54_08680	COG0848	biopolymer transport protein
A8A54_08690	COG0824	Thioesterase
A8A54_08695	COG2255	four-way junction helicase activity
A8A54_08700	COG0632	four-way junction helicase activity
A8A54_08740	COG0483	inositol monophosphate 1-phosphatase activity
A8A54_08755	COG1132	(ABC) transporter
A8A54_08770	COG0217	transcriptional regulatory protein
A8A54_08780	COG1268	BioY protein
A8A54_08790	COG1692	metallophosphoesterase
A8A54_08840	COG2133	pyrroloquinoline quinone binding
A8A54_08845	COG3588	fructose-bisphosphate aldolase
A8A54_08855	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_08865	COG0693	protein deglycase activity
A8A54_08880	COG0604	alcohol dehydrogenase
A8A54_08905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8A54_08910	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8A54_08920	COG0457	Tetratricopeptide repeat
A8A54_08925	COG0469	pyruvate kinase activity
A8A54_08940	COG3750	Belongs to the UPF0335 family
A8A54_08945	COG0667	Aldo Keto reductase
A8A54_08965	COG4143	(ABC) transporter
A8A54_08975	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A8A54_08980	COG4783	chaperone-mediated protein folding
A8A54_08985	COG2258	MOSC domain
A8A54_08990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8A54_09015	COG0183	Belongs to the thiolase family
A8A54_09025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A8A54_09035	COG0142	geranyltranstransferase activity
A8A54_09040	COG1733	regulation of RNA biosynthetic process
A8A54_09045	COG2814	Major facilitator Superfamily
A8A54_09050	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8A54_09055	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_09060	COG2223	nitrite transmembrane transporter activity
A8A54_09070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8A54_09090	COG0410	ABC transporter
A8A54_09095	COG0411	ABC transporter
A8A54_09105	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8A54_09115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_09135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8A54_09140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A8A54_09145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8A54_09150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8A54_09190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A8A54_09200	COG5425	PFAM Usg family protein
A8A54_09205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8A54_09225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8A54_09225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8A54_09235	COG0138	bifunctional purine biosynthesis protein purh
A8A54_09240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A8A54_09245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8A54_09250	COG2270	Major facilitator Superfamily
A8A54_09265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A8A54_09270	COG1704	LemA family
A8A54_09285	COG1605	Chorismate mutase
A8A54_09285	COG0287	Prephenate dehydrogenase
A8A54_09290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8A54_09295	COG1620	l-lactate permease
A8A54_09305	COG0288	reversible hydration of carbon dioxide
A8A54_09310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A8A54_09320	COG2130	NADP-dependent
A8A54_09350	COG0494	nUDIX hydrolase
A8A54_09355	COG0793	Belongs to the peptidase S41A family
A8A54_09375	COG1442	glycosyl transferase family 8
A8A54_09380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8A54_09385	COG0799	negative regulation of ribosome biogenesis
A8A54_09395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A8A54_09400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A8A54_09405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8A54_09435	COG0431	NADPH-dependent FMN reductase
A8A54_09445	COG0500	methyltransferase
A8A54_09455	COG0534	Mate efflux family protein
A8A54_09505	COG0601	transmembrane transport
A8A54_09510	COG0747	negative chemotaxis
A8A54_09535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_09540	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_09555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8A54_09565	COG1309	transcriptional regulator
A8A54_09590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8A54_09590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8A54_09600	COG0583	DNA-binding transcription factor activity
A8A54_09615	COG3191	aminopeptidase activity
A8A54_09620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8A54_09640	COG1663	tetraacyldisaccharide 4'-kinase activity
A8A54_09645	COG1519	Transferase
A8A54_09660	COG0483	inositol monophosphate 1-phosphatase activity
A8A54_09665	COG0312	modulator of DNA gyrase
A8A54_09670	COG0475	glutathione-regulated potassium exporter activity
A8A54_09670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8A54_09680	COG0612	Peptidase, M16
A8A54_09685	COG0612	Peptidase, M16
A8A54_09690	COG0742	ribosomal rna small subunit methyltransferase
A8A54_09700	COG0590	tRNA wobble adenosine to inosine editing
A8A54_09705	COG3038	cytochrome b561
A8A54_09725	COG0196	riboflavin kinase activity
A8A54_09740	COG0459	protein refolding
A8A54_09760	COG0114	fumarate hydratase activity
A8A54_09765	COG2259	Doxx family
A8A54_09775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8A54_09795	COG2818	Glycosylase
A8A54_09800	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_09800	COG1388	LysM domain
A8A54_09815	COG1522	sequence-specific DNA binding
A8A54_09820	COG0247	lactate metabolic process
A8A54_09825	COG0277	FAD linked oxidase domain protein
A8A54_09830	COG0277	FAD linked oxidase domain protein
A8A54_09835	COG0583	DNA-binding transcription factor activity
A8A54_09845	COG2186	Transcriptional regulator
A8A54_09875	COG1846	Transcriptional regulator
A8A54_09880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8A54_09890	COG0583	DNA-binding transcription factor activity
A8A54_09905	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_09910	COG1570	exodeoxyribonuclease VII activity
A8A54_09915	COG0583	DNA-binding transcription factor activity
A8A54_10050	COG4974	Belongs to the 'phage' integrase family
A8A54_10080	COG2233	PERMEase
A8A54_10085	COG4214	carbohydrate transport
A8A54_10090	COG1129	ABC transporter
A8A54_10095	COG4213	ABC transporter substrate-binding protein
A8A54_10100	COG1609	Transcriptional regulator
A8A54_10105	COG1070	Carbohydrate kinase
A8A54_10110	COG2115	Belongs to the xylose isomerase family
A8A54_10115	COG2194	sulfuric ester hydrolase activity
A8A54_10120	COG0673	inositol 2-dehydrogenase activity
A8A54_10130	COG1879	ABC-type sugar transport system periplasmic component
A8A54_10135	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_10140	COG1129	ABC transporter
A8A54_10155	COG0745	RESPONSE REGULATOR receiver
A8A54_10155	COG3706	GGDEF domain
A8A54_10160	COG2814	Major facilitator Superfamily
A8A54_10170	COG2081	HI0933 family
A8A54_10185	COG1088	dTDP-glucose 4,6-dehydratase activity
A8A54_10195	COG0277	FAD linked oxidase domain protein
A8A54_10200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A8A54_10200	COG0546	phosphoglycolate phosphatase activity
A8A54_10205	COG5002	protein histidine kinase activity
A8A54_10205	COG3447	MASE1 domain protein
A8A54_10205	COG5001	Diguanylate cyclase
A8A54_10215	COG0402	S-adenosylhomocysteine deaminase activity
A8A54_10225	COG0154	amidase activity
A8A54_10255	COG2239	Acts as a magnesium transporter
A8A54_10260	COG2814	Major facilitator Superfamily
A8A54_10265	COG0339	signal peptide processing
A8A54_10300	COG0066	3-isopropylmalate dehydratase activity
A8A54_10320	COG1764	response to oxidative stress
A8A54_10325	COG1846	Transcriptional regulator
A8A54_10330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8A54_10335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8A54_10350	COG2169	Transcriptional regulator
A8A54_10350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A8A54_10390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_10395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_10400	COG4592	Periplasmic binding protein
A8A54_10405	COG1120	ATPase activity
A8A54_10415	COG1629	transport
A8A54_10415	COG4774	siderophore transport
A8A54_10430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8A54_10435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8A54_10465	COG1473	amidohydrolase
A8A54_10470	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_10475	COG1414	Transcriptional regulator
A8A54_10480	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_10505	COG1780	Probably involved in ribonucleotide reductase function
A8A54_10515	COG0300	oxidoreductase activity
A8A54_10520	COG1454	alcohol dehydrogenase
A8A54_10545	COG4178	(ABC) transporter
A8A54_10550	COG3842	ATPase activity
A8A54_10555	COG1653	transport
A8A54_10560	COG0395	ABC-type sugar transport system, permease component
A8A54_10585	COG3142	Participates in the control of copper homeostasis
A8A54_10595	COG2222	sugar isomerase
A8A54_10600	COG1940	carbohydrate kinase activity
A8A54_10605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8A54_10610	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
A8A54_10615	COG1473	amidohydrolase
A8A54_10655	COG2423	ornithine cyclodeaminase activity
A8A54_10660	COG4187	Peptidase family M20/M25/M40
A8A54_10690	COG0477	Major facilitator Superfamily
A8A54_10700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8A54_10725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8A54_10730	COG2181	nitrate reductase activity
A8A54_10735	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A8A54_10740	COG1140	nitrate reductase beta subunit
A8A54_10745	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A8A54_10750	COG2223	nitrite transmembrane transporter activity
A8A54_10765	COG0714	Associated with various cellular activities
A8A54_10770	COG3256	nitric oxide reductase
A8A54_10785	COG1845	cytochrome c oxidase, subunit III
A8A54_10795	COG0288	reversible hydration of carbon dioxide
A8A54_10815	COG2151	metal-sulfur cluster biosynthetic enzyme
A8A54_10855	COG0583	DNA-binding transcription factor activity
A8A54_10860	COG2814	Major facilitator Superfamily
A8A54_10865	COG2140	Oxalate decarboxylase
A8A54_10870	COG4566	intracellular signal transduction
A8A54_10875	COG4566	intracellular signal transduction
A8A54_10910	COG2205	protein histidine kinase activity
A8A54_10935	COG3833	ABC-type maltose transport systems, permease component
A8A54_10940	COG0395	ABC-type sugar transport system, permease component
A8A54_10950	COG3842	ATPase activity
A8A54_10955	COG0583	DNA-binding transcription factor activity
A8A54_10970	COG1136	(ABC) transporter
A8A54_10995	COG0242	peptide deformylase activity
A8A54_11005	COG1192	Involved in chromosome partitioning
A8A54_11010	COG1475	DNA binding
A8A54_11015	COG1414	Transcriptional regulator
A8A54_11030	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8A54_11060	COG3468	outer membrane autotransporter barrel domain protein
A8A54_11065	COG2862	Uncharacterized protein family, UPF0114
A8A54_11070	COG0745	RESPONSE REGULATOR receiver
A8A54_11075	COG2205	protein histidine kinase activity
A8A54_11080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A8A54_11085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A8A54_11090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A8A54_11100	COG0252	asparaginase activity
A8A54_11105	COG1113	amino acid transport
A8A54_11110	COG1027	Aspartate ammonia-lyase
A8A54_11115	COG2186	Transcriptional regulator
A8A54_11120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8A54_11130	COG2079	MmgE PrpD family protein
A8A54_11135	COG1126	abc transporter atp-binding protein
A8A54_11140	COG0765	amino acid transport
A8A54_11155	COG2373	Large extracellular alpha-helical protein
A8A54_11160	COG4953	penicillin-binding protein 1C
A8A54_11185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_11190	COG1957	nucleoside hydrolase
A8A54_11215	COG1744	ABC transporter substrate-binding protein PnrA-like
A8A54_11225	COG3842	ATPase activity
A8A54_11230	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_11235	COG1177	transmembrane transport
A8A54_11260	COG2814	Major facilitator Superfamily
A8A54_11265	COG0640	Transcriptional regulator
A8A54_11345	COG0483	inositol monophosphate 1-phosphatase activity
A8A54_11360	COG0071	Belongs to the small heat shock protein (HSP20) family
A8A54_11370	COG0070	glutamate synthase
A8A54_11370	COG0067	glutamate synthase
A8A54_11370	COG0069	glutamate synthase activity
A8A54_11380	COG1113	amino acid transport
A8A54_11390	COG2951	lytic endotransglycosylase activity
A8A54_11395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8A54_11400	COG0829	nickel cation binding
A8A54_11405	COG0831	urea catabolic process
A8A54_11425	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A8A54_11435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8A54_11440	COG0583	DNA-binding transcription factor activity
A8A54_11445	COG4774	siderophore transport
A8A54_11450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A8A54_11465	COG0583	DNA-binding transcription factor activity
A8A54_11490	COG1585	Membrane protein implicated in regulation of membrane protease activity
A8A54_11495	COG0330	HflC and HflK could
A8A54_11500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8A54_11510	COG5310	Homospermidine synthase
A8A54_11530	COG2204	response regulator
A8A54_11535	COG3108	Peptidase M15
A8A54_11540	COG0800	Aldolase
A8A54_11555	COG0725	ABC transporter, periplasmic molybdate-binding protein
A8A54_11560	COG4149	molybdate abc transporter
A8A54_11565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A8A54_11580	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A8A54_11590	COG0583	DNA-binding transcription factor activity
A8A54_11605	COG3153	acetyltransferase
A8A54_11610	COG3206	protein involved in exopolysaccharide biosynthesis
A8A54_11610	COG0489	protein tyrosine kinase activity
A8A54_11625	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A8A54_11645	COG0673	inositol 2-dehydrogenase activity
A8A54_11650	COG0673	inositol 2-dehydrogenase activity
A8A54_11660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8A54_11665	COG3842	ATPase activity
A8A54_11695	COG1309	transcriptional regulator
A8A54_11710	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8A54_11715	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8A54_11720	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A8A54_11735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A8A54_11745	COG4786	Flagellar basal body rod
A8A54_11750	COG1157	protein secretion by the type III secretion system
A8A54_11760	COG1815	bacterial-type flagellum-dependent cell motility
A8A54_11765	COG1558	bacterial-type flagellum-dependent cell motility
A8A54_11770	COG1677	Flagellar hook-basal body complex protein FliE
A8A54_11775	COG4786	Flagellar basal body rod
A8A54_11780	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A8A54_11785	COG1706	bacterial-type flagellum-dependent cell motility
A8A54_11805	COG1338	Plays a role in the flagellum-specific transport system
A8A54_11810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A8A54_11825	COG1360	Flagellar Motor Protein
A8A54_11870	COG5443	negative regulation of bacterial-type flagellum assembly
A8A54_11875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A8A54_11885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A8A54_11920	COG0735	belongs to the Fur family
A8A54_11925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8A54_11935	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A8A54_11940	COG0523	cobalamin synthesis protein
A8A54_11945	COG1959	2 iron, 2 sulfur cluster binding
A8A54_12015	COG4566	intracellular signal transduction
A8A54_12030	COG0235	Class ii aldolase
A8A54_12040	COG1802	Transcriptional regulator
A8A54_12055	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_12070	COG1802	Transcriptional regulator
A8A54_12075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8A54_12080	COG1960	acyl-CoA dehydrogenase activity
A8A54_12085	COG1024	Enoyl-CoA hydratase
A8A54_12090	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8A54_12095	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8A54_12095	COG0022	dehydrogenase e1 component
A8A54_12115	COG0601	transmembrane transport
A8A54_12120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_12125	COG0444	Belongs to the ABC transporter superfamily
A8A54_12130	COG4608	Belongs to the ABC transporter superfamily
A8A54_12135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8A54_12200	COG1940	carbohydrate kinase activity
A8A54_12220	COG1522	sequence-specific DNA binding
A8A54_12235	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A8A54_12255	COG1349	DNA-binding transcription factor activity
A8A54_12285	COG1129	ABC transporter
A8A54_12290	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_12295	COG1879	ABC-type sugar transport system periplasmic component
A8A54_12300	COG1349	DNA-binding transcription factor activity
A8A54_12305	COG1070	Carbohydrate kinase
A8A54_12310	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8A54_12325	COG0673	inositol 2-dehydrogenase activity
A8A54_12330	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_12335	COG1129	ABC transporter
A8A54_12345	COG1879	ABC-type sugar transport system periplasmic component
A8A54_12350	COG0287	Prephenate dehydrogenase
A8A54_12360	COG1850	ribulose-bisphosphate carboxylase activity
A8A54_12375	COG0673	inositol 2-dehydrogenase activity
A8A54_12390	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_12395	COG2706	6-phosphogluconolactonase activity
A8A54_12400	COG1609	Transcriptional regulator
A8A54_12405	COG0006	proline dipeptidase activity
A8A54_12415	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_12420	COG1129	ABC transporter
A8A54_12425	COG1129	ABC transporter
A8A54_12435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8A54_12450	COG0477	Major facilitator Superfamily
A8A54_12500	COG0765	amino acid transport
A8A54_12505	COG0765	amino acid transport
A8A54_12520	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_12525	COG2186	Transcriptional regulator
A8A54_12530	COG0473	3-isopropylmalate dehydrogenase activity
A8A54_12530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8A54_12540	COG1070	Carbohydrate kinase
A8A54_12545	COG0415	Belongs to the DNA photolyase family
A8A54_12550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8A54_12570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8A54_12585	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A8A54_12590	COG3806	Anti-sigma factor
A8A54_12595	COG1595	DNA-templated transcription, initiation
A8A54_12600	COG5001	Diguanylate cyclase
A8A54_12600	COG3300	MHYT domain
A8A54_12635	COG0697	spore germination
A8A54_12650	COG4772	TonB-dependent receptor
A8A54_12655	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A8A54_12660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_12665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_12670	COG1120	ATPase activity
A8A54_12680	COG4221	oxidoreductase activity
A8A54_12690	COG0642	Histidine kinase
A8A54_12710	COG3842	ATPase activity
A8A54_12725	COG0745	RESPONSE REGULATOR receiver
A8A54_12730	COG2205	protein histidine kinase activity
A8A54_12755	COG0583	DNA-binding transcription factor activity
A8A54_12800	COG1268	BioY protein
A8A54_12805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A8A54_12810	COG1122	ATPase activity
A8A54_12815	COG1228	amidohydrolase
A8A54_12835	COG0444	Belongs to the ABC transporter superfamily
A8A54_12840	COG4608	Belongs to the ABC transporter superfamily
A8A54_12855	COG3775	system Galactitol-specific IIC component
A8A54_12860	COG0673	inositol 2-dehydrogenase activity
A8A54_12865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8A54_12870	COG0022	dehydrogenase e1 component
A8A54_12875	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8A54_12890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8A54_12900	COG3732	PTS system glucitol sorbitol-specific
A8A54_12935	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_12940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_12945	COG2390	Transcriptional regulator
A8A54_12950	COG3347	Dehydrogenase
A8A54_12950	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_12955	COG0747	negative chemotaxis
A8A54_12965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8A54_12980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_13010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8A54_13015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8A54_13025	COG0784	Response regulator, receiver
A8A54_13030	COG0745	RESPONSE REGULATOR receiver
A8A54_13030	COG3706	GGDEF domain
A8A54_13055	COG0557	exoribonuclease II activity
A8A54_13060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A8A54_13070	COG0758	DNA mediated transformation
A8A54_13080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8A54_13085	COG0540	Belongs to the ATCase OTCase family
A8A54_13090	COG1960	acyl-CoA dehydrogenase activity
A8A54_13095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8A54_13100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8A54_13130	COG0187	DNA topoisomerase II activity
A8A54_13135	COG0697	spore germination
A8A54_13145	COG3920	Histidine kinase
A8A54_13145	COG2202	Pas domain
A8A54_13185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8A54_13185	COG0392	lysyltransferase activity
A8A54_13190	COG0785	Cytochrome C biogenesis protein
A8A54_13210	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A8A54_13215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8A54_13245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8A54_13250	COG1183	phosphatidylcholine synthase activity
A8A54_13300	COG4771	TonB-dependent receptor
A8A54_13310	COG3720	iron ion transport
A8A54_13315	COG4558	Periplasmic binding protein
A8A54_13320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_13325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A8A54_13330	COG1959	2 iron, 2 sulfur cluster binding
A8A54_13335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8A54_13370	COG2814	Major facilitator Superfamily
A8A54_13375	COG2807	transmembrane transport
A8A54_13380	COG0590	tRNA wobble adenosine to inosine editing
A8A54_13390	COG0583	DNA-binding transcription factor activity
A8A54_13400	COG3845	ABC transporter
A8A54_13410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8A54_13415	COG1802	Transcriptional regulator
A8A54_13450	COG4608	Belongs to the ABC transporter superfamily
A8A54_13460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8A54_13465	COG3706	GGDEF domain
A8A54_13490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8A54_13495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8A54_13500	COG1473	amidohydrolase
A8A54_13540	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_13545	COG0583	DNA-binding transcription factor activity
A8A54_13565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8A54_13585	COG0747	negative chemotaxis
A8A54_13590	COG0747	negative chemotaxis
A8A54_13595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8A54_13620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8A54_13670	COG1959	2 iron, 2 sulfur cluster binding
A8A54_13720	COG4977	sequence-specific DNA binding
A8A54_13720	COG1917	Cupin 2, conserved barrel domain protein
A8A54_13725	COG1335	isochorismatase
A8A54_13735	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A8A54_13755	COG0747	negative chemotaxis
A8A54_13770	COG0444	Belongs to the ABC transporter superfamily
A8A54_13775	COG4608	Belongs to the ABC transporter superfamily
A8A54_13810	COG0601	transmembrane transport
A8A54_13815	COG0747	negative chemotaxis
A8A54_13825	COG0583	DNA-binding transcription factor activity
A8A54_13835	COG0435	Glutathione S-transferase
A8A54_13845	COG2826	transposase and inactivated derivatives, IS30 family
A8A54_13860	COG0601	transmembrane transport
A8A54_13865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_13870	COG4172	Belongs to the ABC transporter superfamily
A8A54_13875	COG0492	ferredoxin-NADP+ reductase activity
A8A54_13885	COG3145	DNA-N1-methyladenine dioxygenase activity
A8A54_13890	COG4952	isomerase
A8A54_13895	COG3347	Dehydrogenase
A8A54_13895	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_13900	COG1349	DNA-binding transcription factor activity
A8A54_13915	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_13920	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_13925	COG3254	rhamnose metabolic process
A8A54_13935	COG0477	Major facilitator Superfamily
A8A54_13970	COG0022	dehydrogenase e1 component
A8A54_13985	COG1294	oxidase, subunit
A8A54_13990	COG1271	oxidase subunit
A8A54_13995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A8A54_14000	COG4988	ABC transporter
A8A54_14015	COG2212	antiporter activity
A8A54_14020	COG1863	multisubunit Na H antiporter MnhE subunit
A8A54_14025	COG0651	ATP synthesis coupled electron transport
A8A54_14030	COG1006	Multisubunit Na H antiporter MnhC subunit
A8A54_14035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8A54_14035	COG2111	Na H antiporter
A8A54_14050	COG0747	negative chemotaxis
A8A54_14060	COG1305	Transglutaminase-like
A8A54_14070	COG2308	Evidence 4 Homologs of previously reported genes of
A8A54_14075	COG0521	Mo-molybdopterin cofactor biosynthetic process
A8A54_14110	COG1252	NADH dehydrogenase
A8A54_14115	COG1301	dicarboxylic acid transport
A8A54_14120	COG4191	Histidine kinase
A8A54_14125	COG2204	response regulator
A8A54_14130	COG1120	ATPase activity
A8A54_14135	COG2207	Transcriptional regulator
A8A54_14145	COG3189	MarR family transcriptional regulator
A8A54_14150	COG1132	(ABC) transporter
A8A54_14160	COG4771	TonB-dependent receptor
A8A54_14175	COG0559	Belongs to the binding-protein-dependent transport system permease family
A8A54_14205	COG3119	arylsulfatase activity
A8A54_14215	COG0583	DNA-binding transcription factor activity
A8A54_14225	COG0583	DNA-binding transcription factor activity
A8A54_14230	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_14235	COG2354	Protein conserved in bacteria
A8A54_14250	COG2176	DNA-directed DNA polymerase activity
A8A54_14265	COG2207	Transcriptional regulator
A8A54_14265	COG0662	Cupin 2, conserved barrel domain protein
A8A54_14275	COG1121	(ABC) transporter
A8A54_14280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8A54_14285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A8A54_14290	COG3842	ATPase activity
A8A54_14305	COG1177	transmembrane transport
A8A54_14320	COG0667	Aldo Keto reductase
A8A54_14325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_14355	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8A54_14375	COG0395	ABC-type sugar transport system, permease component
A8A54_14385	COG0471	metal ion transport
A8A54_14385	COG3273	potassium ion transport
A8A54_14390	COG3265	gluconokinase activity
A8A54_14395	COG2186	Transcriptional regulator
A8A54_14400	COG0277	FAD linked oxidase domain protein
A8A54_14415	COG2252	PERMEase
A8A54_14430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8A54_14460	COG2011	ABC-type metal ion transport system permease component
A8A54_14465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A8A54_14470	COG1464	Belongs to the NlpA lipoprotein family
A8A54_14475	COG0436	Aminotransferase
A8A54_14485	COG4771	TonB-dependent receptor
A8A54_14490	COG2819	hydrolase of the alpha beta superfamily
A8A54_14495	COG4607	ABC-type enterochelin transport system periplasmic component
A8A54_14500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_14505	COG4605	iron ion homeostasis
A8A54_14510	COG4604	ABC transporter, ATP-binding protein
A8A54_14520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_14525	COG0601	transmembrane transport
A8A54_14530	COG0747	negative chemotaxis
A8A54_14535	COG4172	Belongs to the ABC transporter superfamily
A8A54_14550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_14565	COG0248	Ppx GppA phosphatase
A8A54_14575	COG0477	Major facilitator Superfamily
A8A54_14585	COG3842	ATPase activity
A8A54_14610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8A54_14630	COG1840	ABC-type Fe3 transport system, periplasmic component
A8A54_14635	COG3842	ATPase activity
A8A54_14650	COG2132	Multicopper oxidase
A8A54_14660	COG0477	Major facilitator Superfamily
A8A54_14665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8A54_14670	COG0450	alkyl hydroperoxide reductase
A8A54_14685	COG0673	inositol 2-dehydrogenase activity
A8A54_14695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_14700	COG3962	Belongs to the TPP enzyme family
A8A54_14710	COG3718	enzyme involved in inositol metabolism
A8A54_14730	COG1840	ABC-type Fe3 transport system, periplasmic component
A8A54_14745	COG1522	sequence-specific DNA binding
A8A54_14795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8A54_14800	COG2814	Major facilitator Superfamily
A8A54_14825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_14840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A8A54_14850	COG2113	Glycine betaine
A8A54_14855	COG4176	ABC-type proline glycine betaine transport system permease component
A8A54_14875	COG1737	Transcriptional regulator
A8A54_14885	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_14900	COG0395	ABC-type sugar transport system, permease component
A8A54_14915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A8A54_14925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8A54_14930	COG1063	alcohol dehydrogenase
A8A54_14935	COG2721	sulfolactate sulfo-lyase activity
A8A54_14940	COG2186	Transcriptional regulator
A8A54_14945	COG0246	Mannitol dehydrogenase
A8A54_14955	COG4585	Histidine kinase
A8A54_14960	COG1879	ABC-type sugar transport system periplasmic component
A8A54_14965	COG1129	ABC transporter
A8A54_14970	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_14980	COG3386	PFAM SMP-30 Gluconolaconase
A8A54_14985	COG1120	ATPase activity
A8A54_14990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_15025	COG1285	pathogenesis
A8A54_15040	COG2205	protein histidine kinase activity
A8A54_15050	COG1177	transmembrane transport
A8A54_15055	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_15060	COG3842	ATPase activity
A8A54_15075	COG2224	Isocitrate lyase
A8A54_15085	COG3781	membrane
A8A54_15100	COG0174	glutamine synthetase
A8A54_15105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_15115	COG0531	amino acid
A8A54_15120	COG1733	regulation of RNA biosynthetic process
A8A54_15125	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_15165	COG1418	mRNA catabolic process
A8A54_15175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8A54_15180	COG0363	glucosamine-6-phosphate deaminase activity
A8A54_15185	COG0129	dihydroxy-acid dehydratase activity
A8A54_15190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8A54_15215	COG4172	Belongs to the ABC transporter superfamily
A8A54_15220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_15230	COG0747	negative chemotaxis
A8A54_15250	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A8A54_15265	COG0697	spore germination
A8A54_15280	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8A54_15280	COG1024	Enoyl-CoA hydratase
A8A54_15285	COG0183	Belongs to the thiolase family
A8A54_15290	COG1960	acyl-CoA dehydrogenase activity
A8A54_15295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A8A54_15300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8A54_15310	COG0583	DNA-binding transcription factor activity
A8A54_15345	COG0730	response to heat
A8A54_15360	COG1201	RNA secondary structure unwinding
A8A54_15370	COG1793	dna ligase
A8A54_15445	COG3179	chitinase
A8A54_15550	COG0740	serine-type endopeptidase activity
A8A54_15630	COG1473	amidohydrolase
A8A54_15640	COG4608	Belongs to the ABC transporter superfamily
A8A54_15645	COG0444	Belongs to the ABC transporter superfamily
A8A54_15655	COG0601	transmembrane transport
A8A54_15660	COG0747	negative chemotaxis
A8A54_15670	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_15675	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_15680	COG1070	Carbohydrate kinase
A8A54_15685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8A54_15695	COG0022	dehydrogenase e1 component
A8A54_15700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8A54_15705	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_15710	COG1129	ABC transporter
A8A54_15725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8A54_15730	COG0765	amino acid transport
A8A54_15735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_15735	COG0723	plastoquinol--plastocyanin reductase activity
A8A54_15740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_15745	COG1126	abc transporter atp-binding protein
A8A54_15750	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_15760	COG1349	DNA-binding transcription factor activity
A8A54_15830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8A54_15835	COG4521	taurine ABC transporter
A8A54_15840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A8A54_15845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_15860	COG0028	Belongs to the TPP enzyme family
A8A54_15890	COG4558	Periplasmic binding protein
A8A54_15900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8A54_15905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8A54_15915	COG0006	proline dipeptidase activity
A8A54_15925	COG1840	ABC-type Fe3 transport system, periplasmic component
A8A54_15930	COG3842	ATPase activity
A8A54_15960	COG0803	Belongs to the bacterial solute-binding protein 9 family
A8A54_15970	COG1121	(ABC) transporter
A8A54_15980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8A54_15990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A8A54_15995	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_16000	COG1522	sequence-specific DNA binding
A8A54_16005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8A54_16010	COG2423	ornithine cyclodeaminase activity
A8A54_16015	COG0006	proline dipeptidase activity
A8A54_16020	COG3608	succinylglutamate desuccinylase aspartoacylase
A8A54_16025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_16030	COG0765	amino acid transport
A8A54_16035	COG0765	amino acid transport
A8A54_16040	COG1126	abc transporter atp-binding protein
A8A54_16045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8A54_16050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_16070	COG1024	Enoyl-CoA hydratase
A8A54_16080	COG3842	ATPase activity
A8A54_16085	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_16090	COG0318	PFAM AMP-dependent synthetase and ligase
A8A54_16100	COG1309	transcriptional regulator
A8A54_16105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8A54_16140	COG0402	S-adenosylhomocysteine deaminase activity
A8A54_16145	COG1063	alcohol dehydrogenase
A8A54_16150	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_16155	COG2084	Dehydrogenase
A8A54_16160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8A54_16170	COG0765	amino acid transport
A8A54_16190	COG1609	Transcriptional regulator
A8A54_16195	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_16200	COG0371	Dehydrogenase
A8A54_16205	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_16210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8A54_16215	COG1070	Carbohydrate kinase
A8A54_16220	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_16225	COG1129	ABC transporter
A8A54_16230	COG1879	ABC-type sugar transport system periplasmic component
A8A54_16235	COG2140	Oxalate decarboxylase
A8A54_16240	COG0800	Aldolase
A8A54_16250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8A54_16265	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_16270	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_16275	COG1129	ABC transporter
A8A54_16280	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_16285	COG1879	ABC-type sugar transport system periplasmic component
A8A54_16305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8A54_16310	COG1473	amidohydrolase
A8A54_16315	COG4172	Belongs to the ABC transporter superfamily
A8A54_16320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_16325	COG0601	transmembrane transport
A8A54_16330	COG0747	negative chemotaxis
A8A54_16345	COG0477	Major facilitator Superfamily
A8A54_16350	COG4191	Histidine kinase
A8A54_16355	COG2204	response regulator
A8A54_16360	COG1609	Transcriptional regulator
A8A54_16365	COG3842	ATPase activity
A8A54_16400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_16410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8A54_16415	COG0747	negative chemotaxis
A8A54_16435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_16440	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_16455	COG0444	Belongs to the ABC transporter superfamily
A8A54_16460	COG4608	Belongs to the ABC transporter superfamily
A8A54_16495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_16510	COG2376	Dihydroxyacetone kinase
A8A54_16515	COG1461	Dihydroxyacetone kinase
A8A54_16520	COG2376	Dihydroxyacetone kinase
A8A54_16525	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_16530	COG1879	ABC-type sugar transport system periplasmic component
A8A54_16535	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_16540	COG1129	ABC transporter
A8A54_16580	COG0739	heme binding
A8A54_16585	COG1376	ErfK ybiS ycfS ynhG family protein
A8A54_16600	COG2890	protein-(glutamine-N5) methyltransferase activity
A8A54_16605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8A54_16615	COG0527	aspartate kinase activity
A8A54_16620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A8A54_16635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8A54_16645	COG1040	competence protein
A8A54_16660	COG0494	nUDIX hydrolase
A8A54_16675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8A54_16680	COG0653	protein targeting
A8A54_16710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A8A54_16715	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8A54_16720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8A54_16725	COG2086	electron transfer activity
A8A54_16735	COG0720	synthase
A8A54_16740	COG0602	queuosine metabolic process
A8A54_16755	COG0300	oxidoreductase activity
A8A54_16765	COG0697	spore germination
A8A54_16770	COG1671	Belongs to the UPF0178 family
A8A54_16775	COG1280	lysine exporter protein (LysE YggA)
A8A54_16780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8A54_16785	COG0165	Argininosuccinate lyase
A8A54_16810	COG2226	methyltransferase
A8A54_16820	COG0287	Prephenate dehydrogenase
A8A54_16850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8A54_16870	COG2884	Cell division ATP-binding protein ftsE
A8A54_16915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8A54_16935	COG2264	protein methyltransferase activity
A8A54_16940	COG0697	spore germination
A8A54_16945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8A54_16950	COG2233	PERMEase
A8A54_16960	COG0745	RESPONSE REGULATOR receiver
A8A54_16980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A8A54_16990	COG0004	ammonium transporteR
A8A54_16995	COG1946	Acyl-CoA thioesterase
A8A54_17000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8A54_17010	COG1764	response to oxidative stress
A8A54_17045	COG3706	GGDEF domain
A8A54_17045	COG0745	RESPONSE REGULATOR receiver
A8A54_17050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8A54_17105	COG1280	lysine exporter protein (LysE YggA)
A8A54_17115	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8A54_17120	COG0567	Dehydrogenase, E1 component
A8A54_17125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A8A54_17130	COG0045	succinate-CoA ligase (ADP-forming) activity
A8A54_17140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A8A54_17150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8A54_17155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8A54_17160	COG0552	protein localization to endoplasmic reticulum
A8A54_17165	COG2917	probably involved in intracellular septation
A8A54_17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8A54_17180	COG2217	Heavy metal translocating P-type atpase
A8A54_17185	COG0789	Transcriptional regulator
A8A54_17200	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A8A54_17205	COG4221	oxidoreductase activity
A8A54_17235	COG4536	flavin adenine dinucleotide binding
A8A54_17260	COG0825	malonyl-CoA metabolic process
A8A54_17265	COG3034	peptidoglycan biosynthetic process
A8A54_17270	COG0425	Belongs to the sulfur carrier protein TusA family
A8A54_17275	COG0523	cobalamin synthesis protein
A8A54_17280	COG1686	Belongs to the peptidase S11 family
A8A54_17285	COG1473	amidohydrolase
A8A54_17295	COG0477	Major facilitator Superfamily
A8A54_17300	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_17315	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_17325	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_17330	COG1024	Enoyl-CoA hydratase
A8A54_17345	COG1609	Transcriptional regulator
A8A54_17360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8A54_17380	COG4120	Belongs to the binding-protein-dependent transport system permease family
A8A54_17400	COG1475	DNA binding
A8A54_17405	COG1192	Involved in chromosome partitioning
A8A54_17415	COG0445	tRNA wobble uridine modification
A8A54_17425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8A54_17430	COG1331	Highly conserved protein containing a thioredoxin domain
A8A54_17435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8A54_17445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8A54_17465	COG0237	dephospho-CoA kinase activity
A8A54_17470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A8A54_17475	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A8A54_17480	COG3030	protein affecting phage T7 exclusion by the F plasmid
A8A54_17490	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A8A54_17515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A8A54_17525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A8A54_17530	COG0131	Imidazoleglycerol-phosphate dehydratase
A8A54_17545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8A54_17550	COG0107	imidazoleglycerol-phosphate synthase activity
A8A54_17555	COG0140	phosphoribosyl-ATP diphosphatase activity
A8A54_17560	COG1072	(Pantothenic acid kinase))
A8A54_17570	COG1652	LysM domain
A8A54_17575	COG0028	Belongs to the TPP enzyme family
A8A54_17580	COG0596	Alpha beta hydrolase
A8A54_17595	COG0745	RESPONSE REGULATOR receiver
A8A54_17600	COG2205	protein histidine kinase activity
A8A54_17605	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A8A54_17610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A8A54_17610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8A54_17615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A8A54_17620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A8A54_17625	COG2205	protein histidine kinase activity
A8A54_17630	COG0802	atpase or kinase
A8A54_17635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8A54_17640	COG2887	Belongs to the helicase family. UvrD subfamily
A8A54_17645	COG1074	ATP-dependent DNA helicase activity
A8A54_17655	COG0747	negative chemotaxis
A8A54_17660	COG0444	Belongs to the ABC transporter superfamily
A8A54_17665	COG4608	Belongs to the ABC transporter superfamily
A8A54_17670	COG0601	transmembrane transport
A8A54_17675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_17680	COG0584	glycerophosphoryl diester phosphodiesterase
A8A54_17690	COG1802	Transcriptional regulator
A8A54_17695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8A54_17705	COG3842	ATPase activity
A8A54_17710	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_17720	COG4948	Mandelate Racemase Muconate Lactonizing
A8A54_17730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8A54_17735	COG2017	converts alpha-aldose to the beta-anomer
A8A54_17745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8A54_17750	COG0285	dihydrofolate synthase activity
A8A54_17760	COG0159	tryptophan synthase activity
A8A54_17770	COG0133	tryptophan synthase activity
A8A54_17795	COG3135	benzoate transporter
A8A54_17820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8A54_17825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8A54_17850	COG2814	Major facilitator Superfamily
A8A54_17865	COG0667	Aldo Keto reductase
A8A54_17890	COG0484	heat shock protein binding
A8A54_17895	COG3963	phosphatidate phosphatase activity
A8A54_17915	COG3386	PFAM SMP-30 Gluconolaconase
A8A54_17925	COG0606	chelatase, subunit chli
A8A54_17930	COG0305	Participates in initiation and elongation during chromosome replication
A8A54_17940	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8A54_17950	COG2832	Protein of unknown function (DUF454)
A8A54_17955	COG0436	Aminotransferase
A8A54_17965	COG0573	inorganic phosphate transmembrane transporter activity
A8A54_17980	COG0704	Plays a role in the regulation of phosphate uptake
A8A54_17985	COG0745	RESPONSE REGULATOR receiver
A8A54_17990	COG3773	Cell wall hydrolase
A8A54_18000	COG2309	aminopeptidase activity
A8A54_18010	COG0783	Belongs to the Dps family
A8A54_18015	COG1214	PFAM Peptidase M22, glycoprotease
A8A54_18020	COG0456	acetyltransferase
A8A54_18030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8A54_18035	COG1702	phosphate starvation-inducible protein PhoH
A8A54_18055	COG1396	sequence-specific DNA binding
A8A54_18060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8A54_18065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8A54_18075	COG0195	Participates in both transcription termination and antitermination
A8A54_18075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8A54_18085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8A54_18085	COG3064	Membrane
A8A54_18090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8A54_18095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8A54_18100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A8A54_18105	COG1185	polyribonucleotide nucleotidyltransferase activity
A8A54_18110	COG2813	Specifically methylates the guanine in position
A8A54_18115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8A54_18125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8A54_18155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8A54_18160	COG0791	NLP P60 protein
A8A54_18170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8A54_18185	COG1024	Enoyl-CoA hydratase
A8A54_18200	COG0592	DNA-directed DNA polymerase activity
A8A54_18235	COG4172	Belongs to the ABC transporter superfamily
A8A54_18240	COG4239	(ABC) transporter, permease
A8A54_18245	COG4174	ABC transporter (Permease)
A8A54_18255	COG4166	transmembrane transport
A8A54_18260	COG3474	cytochrome
A8A54_18265	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A8A54_18270	COG0077	Prephenate dehydratase
A8A54_18270	COG1605	Chorismate mutase
A8A54_18275	COG2816	NAD+ diphosphatase activity
A8A54_18290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8A54_18295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A8A54_18315	COG0583	DNA-binding transcription factor activity
A8A54_18320	COG2855	membrane
A8A54_18325	COG0242	peptide deformylase activity
A8A54_18330	COG0539	negative regulation of cytoplasmic translation
A8A54_18360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A8A54_18365	COG1960	acyl-CoA dehydrogenase activity
A8A54_18370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8A54_18385	COG1024	Enoyl-CoA hydratase
A8A54_18415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8A54_18420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8A54_18425	COG1845	cytochrome c oxidase, subunit III
A8A54_18430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8A54_18440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8A54_18445	COG0583	DNA-binding transcription factor activity
A8A54_18485	COG3706	GGDEF domain
A8A54_18485	COG0745	RESPONSE REGULATOR receiver
A8A54_18495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A8A54_18505	COG3237	CsbD-like
A8A54_18535	COG2814	Major facilitator Superfamily
A8A54_18565	COG1956	GAF domain-containing protein
A8A54_18575	COG0583	DNA-binding transcription factor activity
A8A54_18590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8A54_18595	COG1414	Transcriptional regulator
A8A54_18605	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A8A54_18610	COG0028	Belongs to the TPP enzyme family
A8A54_18620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A8A54_18625	COG0156	8-amino-7-oxononanoate synthase activity
A8A54_18630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A8A54_18640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8A54_18660	COG2207	Transcriptional regulator
A8A54_18670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_18675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_18780	COG1733	regulation of RNA biosynthetic process
A8A54_18845	COG0784	Response regulator, receiver
A8A54_18845	COG4191	Histidine kinase
A8A54_18875	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A8A54_18900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8A54_18900	COG0475	glutathione-regulated potassium exporter activity
A8A54_18915	COG0583	DNA-binding transcription factor activity
A8A54_18960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_18965	COG0765	amino acid transport
A8A54_18970	COG0765	amino acid transport
A8A54_18975	COG1126	abc transporter atp-binding protein
A8A54_18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8A54_18985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A8A54_19005	COG0596	Alpha beta hydrolase
A8A54_19015	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A8A54_19025	COG1960	acyl-CoA dehydrogenase activity
A8A54_19030	COG0583	DNA-binding transcription factor activity
A8A54_19035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8A54_19045	COG1984	allophanate hydrolase subunit 2
A8A54_19055	COG0439	Biotin carboxylase
A8A54_19060	COG0511	ligase activity, forming carbon-carbon bonds
A8A54_19065	COG0583	DNA-binding transcription factor activity
A8A54_19080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A8A54_19085	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_19090	COG0473	3-isopropylmalate dehydrogenase activity
A8A54_19090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8A54_19100	COG1914	H( )-stimulated, divalent metal cation uptake system
A8A54_19140	COG2031	fatty acid transporter
A8A54_19160	COG0765	amino acid transport
A8A54_19185	COG1846	Transcriptional regulator
A8A54_19215	COG2010	Cytochrome c
A8A54_19230	COG2814	Major facilitator Superfamily
A8A54_19270	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_19310	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_19325	COG0583	DNA-binding transcription factor activity
A8A54_19340	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_19345	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_19355	COG0583	DNA-binding transcription factor activity
A8A54_19365	COG1733	regulation of RNA biosynthetic process
A8A54_19370	COG1063	alcohol dehydrogenase
A8A54_19415	COG1396	sequence-specific DNA binding
A8A54_19425	COG2948	multi-organism process
A8A54_19440	COG3846	protein secretion by the type IV secretion system
A8A54_19455	COG3451	type IV secretory pathway VirB4
A8A54_19470	COG4962	Type ii secretion system protein e
A8A54_19475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8A54_19500	COG0477	Major facilitator Superfamily
A8A54_19510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A8A54_19510	COG1017	nitric oxide dioxygenase activity
A8A54_19515	COG2070	2-Nitropropane dioxygenase
A8A54_19520	COG1942	4-Oxalocrotonate Tautomerase
A8A54_19535	COG0741	lytic transglycosylase activity
A8A54_19560	COG1192	Involved in chromosome partitioning
A8A54_19585	COG5489	Protein of unknown function (DUF736)
A8A54_19590	COG2207	Transcriptional regulator
A8A54_19595	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_19605	COG2801	Transposase and inactivated derivatives
A8A54_19615	COG1674	ftsk spoiiie
A8A54_19620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8A54_19695	COG0745	RESPONSE REGULATOR receiver
A8A54_19710	COG0583	DNA-binding transcription factor activity
A8A54_19720	COG2814	Major facilitator Superfamily
A8A54_19725	COG0583	DNA-binding transcription factor activity
A8A54_19730	COG0668	transmembrane transport
A8A54_19745	COG1279	arginine transmembrane transporter activity
A8A54_19755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8A54_19760	COG0667	Aldo Keto reductase
A8A54_19770	COG0579	oxidoreductase
A8A54_19775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8A54_19795	COG4310	Domain of unknown function (DUF2172)
A8A54_19800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8A54_19810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8A54_19815	COG0438	transferase activity, transferring glycosyl groups
A8A54_19855	COG0110	maltose O-acetyltransferase activity
A8A54_19860	COG0628	permease
A8A54_19865	COG1228	amidohydrolase
A8A54_19865	COG2986	histidine ammonia-lyase
A8A54_19895	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A8A54_19900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8A54_19915	COG2197	response regulator
A8A54_19925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A8A54_19935	COG1228	amidohydrolase
A8A54_19945	COG3842	ATPase activity
A8A54_19955	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_19985	COG2308	Evidence 4 Homologs of previously reported genes of
A8A54_20010	COG1732	Glycine betaine
A8A54_20015	COG1174	glycine betaine transport
A8A54_20020	COG1125	glycine betaine transport
A8A54_20025	COG1174	glycine betaine transport
A8A54_20030	COG3550	peptidyl-serine autophosphorylation
A8A54_20060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8A54_20065	COG0626	cystathionine gamma-synthase activity
A8A54_20075	COG2199	diguanylate cyclase activity
A8A54_20090	COG0793	Belongs to the peptidase S41A family
A8A54_20095	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_20100	COG1129	ABC transporter
A8A54_20105	COG1609	Transcriptional regulator
A8A54_20115	COG1609	Transcriptional regulator
A8A54_20120	COG3842	ATPase activity
A8A54_20160	COG2271	Major facilitator Superfamily
A8A54_20165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A8A54_20190	COG5001	Diguanylate cyclase
A8A54_20195	COG2264	protein methyltransferase activity
A8A54_20205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_20210	COG1120	ATPase activity
A8A54_20230	COG1285	pathogenesis
A8A54_20235	COG2610	gluconate transmembrane transporter activity
A8A54_20245	COG0830	nickel cation binding
A8A54_20250	COG4413	Urea transporter
A8A54_20255	COG0804	urea catabolic process
A8A54_20260	COG0832	Belongs to the urease beta subunit family
A8A54_20270	COG0829	nickel cation binding
A8A54_20275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A8A54_20280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A8A54_20295	COG1902	pentaerythritol trinitrate reductase activity
A8A54_20315	COG0784	Response regulator, receiver
A8A54_20315	COG4191	Histidine kinase
A8A54_20320	COG0596	Alpha beta hydrolase
A8A54_20335	COG1566	PFAM secretion protein HlyD family protein
A8A54_20340	COG1289	transmembrane transporter activity
A8A54_20355	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_20405	COG4774	siderophore transport
A8A54_20410	COG2207	Transcriptional regulator
A8A54_20415	COG1629	transport
A8A54_20415	COG4206	TonB-dependent receptor
A8A54_20465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A8A54_20490	COG2186	Transcriptional regulator
A8A54_20505	COG1802	Transcriptional regulator
A8A54_20510	COG4608	Belongs to the ABC transporter superfamily
A8A54_20515	COG0444	Belongs to the ABC transporter superfamily
A8A54_20530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_20545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8A54_20555	COG0402	S-adenosylhomocysteine deaminase activity
A8A54_20565	COG0583	DNA-binding transcription factor activity
A8A54_20575	COG0601	transmembrane transport
A8A54_20580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_20590	COG0156	8-amino-7-oxononanoate synthase activity
A8A54_20610	COG1846	Transcriptional regulator
A8A54_20615	COG2807	transmembrane transport
A8A54_20620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8A54_20625	COG0583	DNA-binding transcription factor activity
A8A54_20660	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8A54_20670	COG1959	2 iron, 2 sulfur cluster binding
A8A54_20680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8A54_20750	COG3609	addiction module antidote protein, CC2985 family
A8A54_20780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A8A54_20790	COG0596	Alpha beta hydrolase
A8A54_20815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8A54_20825	COG1231	oxidoreductase activity
A8A54_20835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A8A54_20875	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
A8A54_20880	COG2948	multi-organism process
A8A54_20885	COG3504	Conjugal transfer protein
A8A54_20890	COG3736	Type IV secretory pathway, component VirB8
A8A54_20900	COG3704	protein secretion by the type IV secretion system
A8A54_20915	COG3451	type IV secretory pathway VirB4
A8A54_20920	COG3702	type iv secretory pathway
A8A54_20925	COG3838	Conjugal transfer protein Trbc
A8A54_20955	COG4166	transmembrane transport
A8A54_20960	COG0601	transmembrane transport
A8A54_20965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_20975	COG2843	Capsule synthesis protein
A8A54_20980	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8A54_21040	COG3505	Type IV secretory pathway VirD4
A8A54_21045	COG5489	Protein of unknown function (DUF736)
A8A54_21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_21085	COG0165	Argininosuccinate lyase
A8A54_21095	COG1175	transmembrane transport
A8A54_21115	COG1414	Transcriptional regulator
A8A54_21120	COG1475	DNA binding
A8A54_21125	COG1192	Involved in chromosome partitioning
A8A54_21280	COG1396	sequence-specific DNA binding
A8A54_21320	COG2801	Transposase and inactivated derivatives
A8A54_21335	COG1414	Transcriptional regulator
A8A54_21345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A8A54_21350	COG0183	Belongs to the thiolase family
A8A54_21355	COG0583	DNA-binding transcription factor activity
A8A54_21360	COG0235	Class ii aldolase
A8A54_21365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8A54_21375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8A54_21380	COG1012	belongs to the aldehyde dehydrogenase family
A8A54_21385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8A54_21390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_21395	COG1126	abc transporter atp-binding protein
A8A54_21400	COG0765	amino acid transport
A8A54_21405	COG0765	amino acid transport
A8A54_21410	COG2086	electron transfer activity
A8A54_21415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8A54_21425	COG3316	Transposase and inactivated derivatives
A8A54_21430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8A54_21435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A8A54_21445	COG1984	allophanate hydrolase subunit 2
A8A54_21450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A8A54_21455	COG0439	Biotin carboxylase
A8A54_21475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A8A54_21480	COG2814	Major facilitator Superfamily
A8A54_21490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8A54_21515	COG4191	Histidine kinase
A8A54_21520	COG4566	intracellular signal transduction
A8A54_21550	COG0668	transmembrane transport
A8A54_21565	COG3077	Addiction module antitoxin, RelB DinJ family
A8A54_21580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A8A54_21585	COG3668	Plasmid stabilization system
A8A54_21620	COG2375	cellular response to nickel ion
A8A54_21625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_21630	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_21665	COG3453	Protein conserved in bacteria
A8A54_21665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8A54_21670	COG0640	Transcriptional regulator
A8A54_21690	COG4325	translation initiation factor activity
A8A54_21710	COG4191	Histidine kinase
A8A54_21710	COG0784	Response regulator, receiver
A8A54_21730	COG3468	outer membrane autotransporter barrel domain protein
A8A54_21770	COG3300	MHYT domain
A8A54_21770	COG5001	Diguanylate cyclase
A8A54_21785	COG0784	Response regulator, receiver
A8A54_21785	COG2205	protein histidine kinase activity
A8A54_21795	COG5342	invasion associated locus B
A8A54_21820	COG2390	Transcriptional regulator
A8A54_21830	COG3833	ABC-type maltose transport systems, permease component
A8A54_21870	COG2066	Belongs to the glutaminase family
A8A54_21880	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
A8A54_21885	COG4423	Transcription factor
A8A54_21900	COG1278	Cold shock
A8A54_21920	COG4774	siderophore transport
A8A54_21935	COG1120	ATPase activity
A8A54_21960	COG3920	Histidine kinase
A8A54_21980	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8A54_21985	COG0747	negative chemotaxis
A8A54_21990	COG0583	DNA-binding transcription factor activity
A8A54_21995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8A54_22000	COG1917	Cupin 2, conserved barrel domain protein
A8A54_22020	COG1129	ABC transporter
A8A54_22025	COG0410	ABC transporter
A8A54_22030	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
A8A54_22055	COG0587	DNA-directed DNA polymerase activity
A8A54_22060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8A54_22090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8A54_22105	COG0693	protein deglycase activity
A8A54_22130	COG0784	Response regulator, receiver
A8A54_22130	COG4191	Histidine kinase
A8A54_22150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8A54_22155	COG1522	sequence-specific DNA binding
A8A54_22160	COG0686	Belongs to the AlaDH PNT family
A8A54_22165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_22180	COG0596	Alpha beta hydrolase
A8A54_22190	COG3135	benzoate transporter
A8A54_22200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8A54_22205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8A54_22210	COG1845	cytochrome c oxidase, subunit III
A8A54_22215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A8A54_22245	COG0708	Exodeoxyribonuclease III
A8A54_22285	COG0667	Aldo Keto reductase
A8A54_22290	COG0583	DNA-binding transcription factor activity
A8A54_22300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8A54_22310	COG2423	ornithine cyclodeaminase activity
A8A54_22325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A8A54_22330	COG1177	transmembrane transport
A8A54_22335	COG1176	ABC-type spermidine putrescine transport system, permease component I
A8A54_22340	COG3842	ATPase activity
A8A54_22365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8A54_22440	COG0628	permease
A8A54_22510	COG2094	Belongs to the DNA glycosylase MPG family
A8A54_22515	COG0655	NAD(P)H dehydrogenase (quinone) activity
A8A54_22520	COG0753	catalase activity
A8A54_22535	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_22640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A8A54_22660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A8A54_22675	COG1049	propionate catabolic process, 2-methylcitrate cycle
A8A54_22705	COG0673	inositol 2-dehydrogenase activity
A8A54_22745	COG0671	phosphoesterase, PA-phosphatase related
A8A54_22750	COG0745	RESPONSE REGULATOR receiver
A8A54_22755	COG5002	protein histidine kinase activity
A8A54_22760	COG2207	Transcriptional regulator
A8A54_22765	COG1064	alcohol dehydrogenase
A8A54_22770	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
A8A54_22775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_22780	COG1172	Belongs to the binding-protein-dependent transport system permease family
A8A54_22820	COG3842	ATPase activity
A8A54_22825	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_22830	COG1063	alcohol dehydrogenase
A8A54_22840	COG2885	chlorophyll binding
A8A54_22845	COG5001	Diguanylate cyclase
A8A54_22845	COG3300	MHYT domain
A8A54_22850	COG1414	Transcriptional regulator
A8A54_22860	COG0765	amino acid transport
A8A54_22865	COG1126	abc transporter atp-binding protein
A8A54_22870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8A54_22880	COG0277	FAD linked oxidase domain protein
A8A54_22945	COG1653	transport
A8A54_22950	COG1175	transmembrane transport
A8A54_22955	COG0395	ABC-type sugar transport system, permease component
A8A54_22965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8A54_22970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_22970	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A8A54_22975	COG3842	ATPase activity
A8A54_23020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A8A54_23030	COG1278	Cold shock
A8A54_23040	COG0411	ABC transporter
A8A54_23045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8A54_23050	COG4948	Mandelate Racemase Muconate Lactonizing
A8A54_23055	COG1301	dicarboxylic acid transport
A8A54_23060	COG3550	peptidyl-serine autophosphorylation
A8A54_23090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8A54_23100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8A54_23110	COG1473	amidohydrolase
A8A54_23120	COG1487	ribonuclease activity
A8A54_23125	COG4691	Plasmid stability protein
A8A54_23130	COG2826	transposase and inactivated derivatives, IS30 family
A8A54_23140	COG1349	DNA-binding transcription factor activity
A8A54_23150	COG1653	transport
A8A54_23155	COG1175	transmembrane transport
A8A54_23180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8A54_23185	COG0235	Class ii aldolase
A8A54_23195	COG1070	Carbohydrate kinase
A8A54_23220	COG3493	citrate carrier protein
A8A54_23230	COG0640	Transcriptional regulator
A8A54_23235	COG1253	flavin adenine dinucleotide binding
A8A54_23245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A8A54_23250	COG1120	ATPase activity
A8A54_23255	COG0174	glutamine synthetase
A8A54_23260	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A8A54_23265	COG1877	trehalose-phosphatase activity
A8A54_23300	COG0798	PFAM Bile acid sodium symporter
A8A54_23305	COG1393	Belongs to the ArsC family
A8A54_23310	COG0431	NADPH-dependent FMN reductase
A8A54_23335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8A54_23355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8A54_23385	COG0346	lactoylglutathione lyase activity
A8A54_23390	COG0400	carboxylic ester hydrolase activity
A8A54_23400	COG2814	Major facilitator Superfamily
A8A54_23415	COG0395	ABC-type sugar transport system, permease component
A8A54_23420	COG1175	transmembrane transport
A8A54_23430	COG3842	ATPase activity
A8A54_23435	COG1028	Short-chain dehydrogenase reductase Sdr
A8A54_23440	COG3622	Belongs to the hyi family
A8A54_23445	COG0235	Class ii aldolase
A8A54_23450	COG3395	kinase activity
A8A54_23455	COG2084	Dehydrogenase
A8A54_23460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8A54_23465	COG2188	Transcriptional regulator