locus-tag class description PDUR_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) PDUR_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) PDUR_00015 ENOG410848D S4 domain protein YaaA PDUR_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) PDUR_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PDUR_00040 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PDUR_00045 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PDUR_00080 ENOG4105CXN decarboxylase PDUR_00085 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) PDUR_00090 ENOG4105X0R protein from nitrogen regulatory protein P-II PDUR_00095 ENOG4105XVJ Protein of unknown function (DUF327) PDUR_00100 ENOG4105FA2 dna polymerase iii PDUR_00105 ENOG4105MA4 psp1 domain protein PDUR_00110 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) PDUR_00115 ENOG41060K3 Methyltransferase PDUR_00120 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) PDUR_00125 ENOG4105KRN Transcriptional regulator, abrb family PDUR_00130 ENOG4105DCI Phosphohydrolase PDUR_00135 ENOG4105F8V Hydrolase, tatD family PDUR_00140 ENOG41069ER domain protein PDUR_00145 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) PDUR_00150 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) PDUR_00155 ENOG4105XFA sporulation peptidase YabG PDUR_00160 ENOG4105W42 Veg protein PDUR_00170 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) PDUR_00175 ENOG4105DFT pur operon repressor PDUR_00180 ENOG4105K4W Could be involved in septation (By similarity) PDUR_00185 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) PDUR_00190 ENOG4105C5T Phosphoribosyl pyrophosphate synthase PDUR_00210 ENOG4108JA2 transcriptioN-repair coupling factor PDUR_00215 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) PDUR_00220 ENOG4108M14 stage v sporulation protein t PDUR_00230 ENOG4108IY2 MazG family PDUR_00235 ENOG4105K70 DNA-binding protein PDUR_00240 ENOG41082I2 s4 domain protein PDUR_00245 ENOG4105VYY sporulation protein yabp PDUR_00260 ENOG41060GV RNA binding s1 domain protein PDUR_00285 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) PDUR_00290 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) PDUR_00295 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) PDUR_00300 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) PDUR_00305 ENOG4108IYU L-aspartate oxidase PDUR_00315 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) PDUR_00320 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) PDUR_00325 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase PDUR_00330 ENOG4105C6T cysteine synthase PDUR_00335 ENOG4105CRQ synthase (Component I) PDUR_00340 ENOG4105DDQ anthranilate synthase PDUR_00345 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 PDUR_00350 ENOG4105EEI dihydropteroate synthase PDUR_00355 ENOG4105KRF dihydroneopterin aldolase PDUR_00360 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase PDUR_00370 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) PDUR_00375 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) PDUR_00400 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) PDUR_00420 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) PDUR_00445 ENOG4105D9U N-acetyltransferase PDUR_00450 ENOG4108Z6B deaminase PDUR_00455 ENOG4105BZU Histidine kinase PDUR_00460 ENOG4105FE9 pseudouridine synthase PDUR_00465 ENOG4105ER2 Ompa motb domain protein PDUR_00470 ENOG4105E14 MotA TolQ exbB proton channel PDUR_00485 ENOG41090A4 Pterin carbinolamine dehydratase PDUR_00500 ENOG4107TT5 NLP P60 protein PDUR_00505 ENOG41068JE domain protein PDUR_00520 ENOG4108XFG YwhD family PDUR_00525 ENOG4107R34 abc transporter permease protein PDUR_00530 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) PDUR_00535 ENOG4105F3H Histidine kinase PDUR_00545 ENOG4108M14 stage v sporulation protein t PDUR_00555 ENOG4108VX5 3-methyladenine DNA glycosylase PDUR_00560 ENOG4105BZ4 penicillin-binding protein PDUR_00575 ENOG4105C75 arginyL-tRNA synthetase PDUR_00590 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) PDUR_00600 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) PDUR_00605 ENOG410812K response regulator receiver protein PDUR_00615 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) PDUR_00620 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) PDUR_00625 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs PDUR_00630 ENOG41082DI 50s ribosomal protein l31 PDUR_00640 ENOG4105C6E dna polymerase iii PDUR_00645 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) PDUR_00650 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) PDUR_00740 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) PDUR_00750 ENOG4107XGZ Hydrolase PDUR_00755 ENOG4108S4C acetyltransferase PDUR_00765 ENOG4105CMG Carbohydrate kinase PDUR_00770 ENOG4105C6Z Gluconate PDUR_00785 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) PDUR_00790 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) PDUR_00795 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) PDUR_00800 ENOG4105ECC imidazole-glycerol-phosphate dehydratase PDUR_00805 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) PDUR_00810 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase PDUR_00820 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) PDUR_00825 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase PDUR_00830 ENOG4107RVV histidinol phosphate phosphatase, hisj family PDUR_00835 ENOG4105C5T Phosphoribosyl pyrophosphate synthase PDUR_00850 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) PDUR_00850 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) PDUR_00865 ENOG4105DKQ ROK family PDUR_00870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) PDUR_00875 ENOG4105CHW UPF0052 protein PDUR_00880 ENOG4105CIE May be required for sporulation (By similarity) PDUR_00885 ENOG4105KRI phosphocarrier protein (HPr PDUR_00905 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) PDUR_00925 ENOG4105BZA Phosphoglycerate kinase PDUR_00930 ENOG4105CP7 Triose-phosphate isomerase PDUR_00935 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) PDUR_00940 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) PDUR_00945 ENOG4105XZU Preprotein translocase, subunit SecG PDUR_00950 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) PDUR_00955 ENOG4105JVQ RNA Polymerase PDUR_00965 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) PDUR_00985 ENOG4105NX3 Membrane PDUR_00990 ENOG4105VMP Transcriptional regulator PDUR_01085 ENOG4108MES Periplasmic binding protein PDUR_01090 ENOG4105DQ5 transport system permease protein PDUR_01095 ENOG4108IHU transport system permease protein PDUR_01105 ENOG410630P Transcriptional regulator PDUR_01110 ENOG4108J2P Alpha beta hydrolase fold PDUR_01115 ENOG41061TZ Short-chain dehydrogenase reductase Sdr PDUR_01125 ENOG4105CF7 AraC family transcriptional regulator PDUR_01140 ENOG4105GZI Transcriptional regulator PDUR_01170 ENOG4105UQX Mate efflux family protein PDUR_01180 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB PDUR_01185 ENOG4107TYR Glycosyl Transferase PDUR_01200 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_01205 ENOG4106FTQ Taurine ABC transporter, periplasmic PDUR_01215 ENOG4105ED1 spovr family PDUR_01225 ENOG4105CYN Serine protein kinase PDUR_01230 ENOG4107XWS modD protein PDUR_01280 ENOG4105CDY transcriptional regulatory protein PDUR_01285 ENOG4105DBI uridine monophosphokinase PDUR_01295 ENOG4105C5W Aldolase PDUR_01300 ENOG4105DCF alanine dehydrogenase PDUR_01305 ENOG4108K8K Transcriptional regulator PDUR_01310 ENOG4105CE7 Amidase, hydantoinase carbamoylase family PDUR_01320 ENOG410645S MarR family Transcriptional regulator PDUR_01325 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin PDUR_01345 ENOG4105BZU Histidine kinase PDUR_01355 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_01365 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) PDUR_01370 ENOG4105D03 DNA-3-methyladenine glycosylase II PDUR_01375 ENOG4105VEQ Cold shock protein PDUR_01380 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PDUR_01400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit PDUR_01410 ENOG4105HBA AroM protein PDUR_01425 ENOG4105G9B Transcriptional regulator PDUR_01430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PDUR_01435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PDUR_01440 ENOG4105DEF Extracellular solute-binding protein, family 5 PDUR_01450 ENOG4105C3U ABC transporter PDUR_01455 ENOG4108JQ7 (ABC) transporter PDUR_01525 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_01545 ENOG4105ENA helicase PDUR_01550 ENOG4107S9D Alpha beta hydrolase PDUR_01580 ENOG4105DA5 (ABC) transporter PDUR_01600 ENOG4105D7K pfkb domain protein PDUR_01615 ENOG41080HJ 6-phospho 3-hexuloisomerase PDUR_01620 ENOG4106BRA Membrane PDUR_01630 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) PDUR_01650 ENOG4108IUM Glycogen debranching enzyme PDUR_01655 ENOG4105BZ8 glutamate synthase PDUR_01660 ENOG4108RE9 Phosphodiesterase PDUR_01675 ENOG4106PMH Extracellular solute-binding protein family 3 PDUR_01680 ENOG4105E5Q amino acid AbC transporter PDUR_01685 ENOG4105CDA abc transporter atp-binding protein PDUR_01690 ENOG4108N0M stress protein PDUR_01695 ENOG4107TS3 membrane protein, TerC PDUR_01705 ENOG4108QTI )-transporter PDUR_01720 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) PDUR_01725 ENOG4105EGI Transcriptional regulator PDUR_01740 ENOG4105BZU Histidine kinase PDUR_01750 ENOG4108HRK Histidine kinase PDUR_01755 ENOG4105DY9 regulatoR PDUR_01760 ENOG4105FCD Major Facilitator PDUR_01815 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PDUR_01820 ENOG4105C26 Dehydrogenase PDUR_01830 ENOG4105C7S Dehydrogenase PDUR_01835 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 PDUR_01845 ENOG4108IMY Transcriptional regulator PDUR_01850 ENOG4107QM2 Aldo Keto reductase PDUR_01865 ENOG4105BZU Histidine kinase PDUR_01890 ENOG4105C59 p-type ATPase PDUR_01910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_01935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_01965 ENOG4105C59 p-type ATPase PDUR_01985 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) PDUR_02005 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein PDUR_02010 ENOG4108I5D sulfate abc transporter PDUR_02030 ENOG4105H67 Protein of unknown function (DUF421) PDUR_02050 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) PDUR_02080 ENOG4105EJQ L-serine dehydratase PDUR_02085 ENOG4105MI2 PDUR_02105 ENOG4108AQF aminoglycoside N(3)-acetyltransferase PDUR_02115 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) PDUR_02120 ENOG4108UZX fmn reductase PDUR_02135 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) PDUR_02140 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) PDUR_02145 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) PDUR_02150 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase PDUR_02190 ENOG4105C5Y PTS System PDUR_02195 ENOG4105BZU Histidine kinase PDUR_02220 ENOG4108JJB ABC transporter PDUR_02225 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) PDUR_02230 ENOG4105CFP Peptidase U32 PDUR_02235 ENOG4105C8Y Acetylornithine aminotransferase PDUR_02240 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) PDUR_02285 ENOG4105CEP NADH dehydrogenase PDUR_02300 ENOG4105BZU Histidine kinase PDUR_02310 ENOG4105K4T epimerase PDUR_02315 ENOG4105KME endoribonuclease L-psp PDUR_02330 ENOG4105C0D helicase PDUR_02360 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) PDUR_02380 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) PDUR_02395 ENOG41064X9 cytochrome C oxidase subunit IV PDUR_02420 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_02455 ENOG4105DVE abc transporter atp-binding protein PDUR_02460 ENOG4108IUX (ABC) transporter PDUR_02465 ENOG4105RHA ABC transporter, permease PDUR_02470 ENOG4107U9B transcriptional regulator PDUR_02475 ENOG4105JAB phenazine biosynthesis protein, phzf family PDUR_02480 ENOG4105BZ1 (ABC) transporter PDUR_02490 ENOG4105CCT upf0313 protein PDUR_02535 ENOG4108SUT Major Facilitator Superfamily PDUR_02540 ENOG4105ENX hydrolase PDUR_02565 ENOG4105DXI Major Facilitator superfamily PDUR_02580 ENOG4108IQ3 PTS system PDUR_02590 ENOG4105F3R pts system mannose fructose sorbose family iid PDUR_02600 ENOG4105CG3 alpha amylase, catalytic region PDUR_02605 ENOG4108Q3X Transcriptional regulator PDUR_02610 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PDUR_02615 ENOG4105DQ4 alcohol dehydrogenase PDUR_02620 ENOG4105ST3 Transcriptional regulator PDUR_02625 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase PDUR_02630 ENOG4105CPC Aldo Keto reductase PDUR_02635 ENOG4108RWP Major Facilitator Superfamily protein PDUR_02640 ENOG4105CF7 AraC family transcriptional regulator PDUR_02645 ENOG4105CPC Aldo Keto reductase PDUR_02660 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PDUR_02665 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component PDUR_02670 ENOG4105C2F Histidine kinase PDUR_02675 ENOG4105EQD regulatoR PDUR_02680 ENOG4105CHR reductase PDUR_02685 ENOG4105D94 Major Facilitator Superfamily PDUR_02690 ENOG4107TXC Transcriptional regulator PDUR_02715 ENOG4107R4J Chloride channel PDUR_02735 ENOG4105CZM Major Facilitator PDUR_02740 ENOG4108Z6Z Transcriptional regulator PDUR_02750 ENOG4108IXY short-chain dehydrogenase reductase PDUR_02790 ENOG4105JVQ RNA Polymerase PDUR_02795 ENOG4108TVJ Nitroreductase PDUR_02800 ENOG41067V3 Antibiotic biosynthesis monooxygenase PDUR_02805 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase PDUR_02820 ENOG4105CHH sulfate transporter PDUR_02835 ENOG4105CG3 alpha amylase, catalytic region PDUR_02860 ENOG4105EQD regulatoR PDUR_02875 ENOG41080UX Methyltransferase PDUR_02885 ENOG41061CK Antibiotic biosynthesis monooxygenase PDUR_02900 ENOG4105EDW glycosyl transferase, family 39 PDUR_02905 ENOG4105CKK Glycosyl transferase, family 2 PDUR_02920 ENOG4105CKK Glycosyl transferase, family 2 PDUR_02935 ENOG4105XN3 extracellular solute-binding protein family 1 PDUR_02950 ENOG4105U5Y Transcriptional regulator PDUR_02960 ENOG4108TVJ Nitroreductase PDUR_03040 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) PDUR_03045 ENOG4107SKW Inherit from COG: Alpha beta hydrolase PDUR_03050 ENOG41067SE Tetr family transcriptional regulator PDUR_03060 ENOG4107V2S Transcriptional regulator PDUR_03070 ENOG4105CIS alcohol dehydrogenase PDUR_03075 ENOG4105KVH Transcriptional regulator PDUR_03090 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase PDUR_03105 ENOG4105GR3 Histidine kinase PDUR_03110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_03115 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) PDUR_03140 ENOG41068WN PDUR_03145 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_03155 ENOG4107Y80 Major Facilitator superfamily PDUR_03170 ENOG4105CBX hi0933 family PDUR_03185 ENOG4108Y6J UPF0403 protein PDUR_03200 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) PDUR_03215 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) PDUR_03220 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) PDUR_03230 ENOG4105EUJ GTP cyclohydrolase i PDUR_03235 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) PDUR_03245 ENOG4107258 Transcriptional regulator PDUR_03260 ENOG4105C6T cysteine synthase PDUR_03275 ENOG4105ESN nucleotide-binding protein PDUR_03285 ENOG4105D7W serine acetyltransferase PDUR_03290 ENOG4107QM5 aconitate hydratase PDUR_03300 ENOG4105CPF Cell wall formation (By similarity) PDUR_03320 ENOG4105ECY inositol monophosphatase PDUR_03335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) PDUR_03340 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase PDUR_03350 ENOG4108KGH TRANSCRIPTIONal PDUR_03355 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PDUR_03380 ENOG4107ZTW SNARE associated Golgi PDUR_03385 ENOG4107VMI polysaccharide deacetylase PDUR_03410 ENOG4107RBJ symporter PDUR_03415 ENOG4105C7N Xanthine uracil vitamin C permease PDUR_03430 ENOG4105CKK Glycosyl transferase, family 2 PDUR_03470 ENOG4105KVH Transcriptional regulator PDUR_03485 ENOG4107YZX Universal stress protein PDUR_03505 ENOG4108JJB ABC transporter PDUR_03515 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) PDUR_03535 ENOG4108SHJ s-layer protein PDUR_03575 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) PDUR_03580 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit PDUR_03585 ENOG4105C83 adenylosuccinate lyase PDUR_03590 ENOG4105C8V SAICAR synthetase PDUR_03595 ENOG4105VR9 phosphoribosylformylglycinamidine synthase PDUR_03600 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I PDUR_03605 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii PDUR_03620 ENOG4105CXB phosphoribosylaminoimidazole synthetase PDUR_03625 ENOG4108V3E phosphoribosylglycinamide formyltransferase PDUR_03635 ENOG4105C12 Phosphoribosylglycinamide synthetase PDUR_03640 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving PDUR_03645 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_03655 ENOG4105C7B Threonine dehydratase PDUR_03665 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PDUR_03680 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b PDUR_03700 ENOG4105ETE Transcriptional regulator (LacI family PDUR_03705 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component PDUR_03710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PDUR_03720 ENOG4105E0C molybdate abc transporter PDUR_03730 ENOG4108R5T secreted protein PDUR_03735 ENOG4107GRR phosphate transport regulator PDUR_03740 ENOG4105CJ3 phosphate transporter PDUR_03745 ENOG4105CDA abc transporter atp-binding protein PDUR_03750 ENOG4105CT1 (ABC) transporter PDUR_03755 ENOG4105EAD ABC transporter PDUR_03760 ENOG4105DRP amino acid AbC transporter PDUR_03775 ENOG4105D7N magnesium and cobalt transport protein CorA PDUR_03785 ENOG4105KGF protein, YerC YecD PDUR_03795 ENOG4105CBD Diacylglycerol kinase PDUR_03800 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) PDUR_03840 ENOG4106ANW SMI1_KNR4 PDUR_03905 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) PDUR_03915 ENOG41065RQ ADP-ribosylation crystallin J1 PDUR_03940 ENOG410756H nucleotidyltransferase PDUR_03985 ENOG4105KVH Transcriptional regulator PDUR_04010 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) PDUR_04015 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase PDUR_04020 ENOG4105CPD ethanolamine ammonia-lyase PDUR_04025 ENOG4107FQ9 ethanolamine ammonia-lyase PDUR_04040 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase PDUR_04050 ENOG4105DEF Extracellular solute-binding protein, family 5 PDUR_04055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PDUR_04060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PDUR_04065 ENOG4105C3U ABC transporter PDUR_04070 ENOG4108JQ7 (ABC) transporter PDUR_04170 ENOG4105EKQ RNA-directed DNA polymerase PDUR_04305 ENOG4105GZI Transcriptional regulator PDUR_04310 ENOG41067SE Tetr family transcriptional regulator PDUR_04315 ENOG4107S9D Alpha beta hydrolase PDUR_04325 ENOG4108NHD germination protein PDUR_04355 ENOG4105S10 periplasmic binding protein PDUR_04360 ENOG4105JXH GntR family transcriptional regulator PDUR_04370 ENOG4105E2X shikimate dehydrogenase PDUR_04385 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) PDUR_04410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PDUR_04415 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PDUR_04420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) PDUR_04425 ENOG4105VZ8 Transcriptional regulator PDUR_04455 ENOG4105VEM Conserved domain protein PDUR_04495 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_04505 ENOG4105MSB protein, conserved in bacteria PDUR_04685 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_04730 ENOG4108J53 cell adhesion domain-containing protein PDUR_04945 ENOG4105CYX Short-chain dehydrogenase reductase Sdr PDUR_04950 ENOG4105CF7 AraC family transcriptional regulator PDUR_04970 ENOG4108V4B ThiJ pfpI PDUR_04980 ENOG4108VP3 Lysine exporter protein (LysE YggA) PDUR_04985 ENOG4105ECQ AraC Family Transcriptional Regulator PDUR_05000 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_05005 ENOG4105D7V transposase PDUR_05030 ENOG4105E1F short-chain dehydrogenase reductase PDUR_05035 ENOG4105C26 Dehydrogenase PDUR_05040 ENOG4105E1F short-chain dehydrogenase reductase PDUR_05045 ENOG4108DMH HTH_ARAC PDUR_05110 ENOG41075D4 Aminoglycoside 6-adenylyltransferase PDUR_05120 ENOG4105BZU Histidine kinase PDUR_05145 ENOG4105EMU Dehydrogenase PDUR_05165 ENOG4105CB2 alcohol dehydrogenase PDUR_05185 ENOG4107FQX Alpha-acetolactate decarboxylase PDUR_05205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) PDUR_05210 ENOG4105CAQ asparagine synthetase PDUR_05225 ENOG4105BZ1 (ABC) transporter PDUR_05230 ENOG4105D7V transposase PDUR_05240 ENOG4105D0B Nitrogenase protein alpha chain PDUR_05250 ENOG4105RYY domain protein PDUR_05260 ENOG4105DKT Transcriptional regulator PDUR_05265 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) PDUR_05270 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) PDUR_05280 ENOG4107YJ4 chain length determinant protein PDUR_05290 ENOG4108PQP glycosyl transferase group 1 PDUR_05300 ENOG4108KMV Glycosyl transferase (Group 1 PDUR_05310 ENOG41068W6 Capsular polysaccharide biosynthesis protein PDUR_05320 ENOG4105D3Q Sugar transferase PDUR_05325 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase PDUR_05345 ENOG4107QRS glycosyltransferase group 2 family protein PDUR_05375 ENOG4105CMR udp-glucose 4-epimerase PDUR_05395 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) PDUR_05405 ENOG4105C0D helicase PDUR_05420 ENOG4105CJ1 ABC, transporter PDUR_05430 ENOG4105D29 Helix-turn-helix type 11 domain protein PDUR_05460 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase PDUR_05470 ENOG4105EWC Purine nucleoside phosphorylase PDUR_05605 ENOG4105C5Q Transcriptional regulator PDUR_05620 ENOG4105EMV Major Facilitator PDUR_05625 ENOG4105FF2 Type I DHQase PDUR_05630 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) PDUR_05635 ENOG4107TXC Transcriptional regulator PDUR_05650 ENOG4105D98 threonine synthase PDUR_05655 ENOG4105EE0 oxidoreductase PDUR_05670 ENOG4105YVS arsR family transcriptional regulator PDUR_05675 ENOG4105FR1 rard protein PDUR_05680 ENOG4105EMV Major Facilitator PDUR_05690 ENOG4105ETE Transcriptional regulator (LacI family PDUR_05700 ENOG4108HKT sucrose-6-phosphate hydrolase PDUR_05715 ENOG4108UKS UPF0398 protein PDUR_05745 ENOG4105M6F mutator MutT protein PDUR_05845 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_05855 ENOG4105CCU oxidase (Subunit III) PDUR_05865 ENOG4105E2S oxidase) subunit II PDUR_05870 ENOG4107VMI polysaccharide deacetylase PDUR_05885 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family PDUR_05890 ENOG4105DVE abc transporter atp-binding protein PDUR_05905 ENOG4105F27 Major Facilitator PDUR_05910 ENOG4107TXC Transcriptional regulator PDUR_05925 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase PDUR_05930 ENOG4108Z40 Transcriptional regulator PDUR_05950 ENOG4107RDP Dehydrogenase PDUR_05955 ENOG4107ZE5 PPIases accelerate the folding of proteins PDUR_05970 ENOG4108HGU Histidine kinase PDUR_05990 ENOG4105WH1 Two component transcriptional regulator luxr family PDUR_06000 ENOG4107YJ4 chain length determinant protein PDUR_06005 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase PDUR_06010 ENOG4105D3Q Sugar transferase PDUR_06015 ENOG4107XZA Glycosyl transferase family 2 PDUR_06045 ENOG4105E2K Glycosyl transferase (Group 1 PDUR_06050 ENOG4105JNK Glycosyl transferase (Group 1 PDUR_06055 ENOG4105C6Y Udp-glucose 6-dehydrogenase PDUR_06060 ENOG4105CJT Mannose-1-phosphate guanylyltransferase PDUR_06065 ENOG41086IN PA14 PDUR_06080 ENOG4108WPJ Ferritin-like domain PDUR_06110 ENOG4108JQ7 (ABC) transporter PDUR_06115 ENOG4105DEF Extracellular solute-binding protein, family 5 PDUR_06120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PDUR_06125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PDUR_06130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein PDUR_06135 ENOG4105E0C molybdate abc transporter PDUR_06140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family PDUR_06150 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein PDUR_06170 ENOG4105F0V Cell wall hydrolase PDUR_06175 ENOG4105E8R UPF0173 metal-dependent hydrolase PDUR_06180 ENOG4108QBV Monogalactosyldiacylglycerol synthase PDUR_06190 ENOG4105ECB domain protein PDUR_06205 ENOG4105CJ1 ABC, transporter PDUR_06210 ENOG4108TU7 Inherit from COG: (ABC) transporter PDUR_06220 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) PDUR_06225 ENOG4108JYZ YitT family PDUR_06230 ENOG4105DQE DNA ligase PDUR_06235 ENOG4108J9Q DNA ligase PDUR_06240 ENOG4105FDF Could be involved in DNA repair (By similarity) PDUR_06260 ENOG4105K8N protein family UPF0079, ATPase PDUR_06265 ENOG41072GX Peptidase M22 Glycoprotease PDUR_06270 ENOG410801F ribosomal-protein-alanine acetyltransferase PDUR_06275 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) PDUR_06290 ENOG4105C5H ABC transporter PDUR_06295 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase PDUR_06300 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PDUR_06305 ENOG4108RIR Molybdenum cofactor biosynthesis protein PDUR_06310 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) PDUR_06315 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) PDUR_06320 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) PDUR_06325 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) PDUR_06370 ENOG4105C28 cystathionine PDUR_06375 ENOG4105CH2 amidohydrolase PDUR_06380 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PDUR_06385 ENOG4108UMI ABC transporter, permease PDUR_06395 ENOG4105D01 (LipO)protein PDUR_06400 ENOG4105II7 pyrroline-5-carboxylate reductase PDUR_06450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PDUR_06480 ENOG4105C2F Histidine kinase PDUR_06485 ENOG4105EQD regulatoR PDUR_06485 ENOG4105EQD regulatoR PDUR_06495 ENOG4105K56 Transcriptional regulator PDUR_06505 ENOG4105CPC Aldo Keto reductase PDUR_06530 ENOG4105CBT Fructose-1,6-bisphosphatase PDUR_06535 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) PDUR_06550 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PDUR_06555 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) PDUR_06560 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) PDUR_06565 ENOG4105CE1 Ferrous iron transport protein b PDUR_06570 ENOG4105CE1 Ferrous iron transport protein b PDUR_06595 ENOG4108Q5U germination protein, ger(x)c family PDUR_06610 ENOG4108QXE glycerophosphoryl diester phosphodiesterase PDUR_06615 ENOG4105CG3 alpha amylase, catalytic region PDUR_06635 ENOG4108JP0 extracellular solute-binding protein family 1 PDUR_06640 ENOG4105ETE Transcriptional regulator (LacI family PDUR_06650 ENOG4105ETE Transcriptional regulator (LacI family PDUR_06665 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component PDUR_06670 ENOG4105E0S extracellular solute-binding protein family 1 PDUR_06675 ENOG4108HKT sucrose-6-phosphate hydrolase PDUR_06680 ENOG4108HKT sucrose-6-phosphate hydrolase PDUR_06715 ENOG4108VZI ErfK ybiS ycfS ynhG family protein PDUR_06720 ENOG4105HHM rdd domain containing protein PDUR_06730 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PDUR_06735 ENOG4105C5H ABC transporter PDUR_06750 ENOG4108IG5 Transcriptional regulator PDUR_06760 ENOG4105KWG Pfam:DUF1696 PDUR_06775 ENOG41090MY MarR family Transcriptional regulator PDUR_06785 ENOG4108VGI doxx family PDUR_06795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PDUR_06835 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_06865 ENOG4105KVH Transcriptional regulator PDUR_06875 ENOG4105CX6 glutaminyL-tRNA synthetase PDUR_06885 ENOG4108N23 SpoOM-related protein PDUR_06905 ENOG4108NGH radical SAM domain protein PDUR_06955 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein PDUR_06960 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) PDUR_06970 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) PDUR_07015 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) PDUR_07020 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) PDUR_07025 ENOG4105E98 transcriptional regulator DeoR family PDUR_07030 ENOG4105DE4 1-phosphofructokinase PDUR_07095 ENOG4105C32 Amino acid ABC transporter (Permease) PDUR_07100 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PDUR_07105 ENOG4105C0Z ABC transporter PDUR_07110 ENOG4108IV0 ABC, transporter PDUR_07115 ENOG4105CP9 extracellular ligand-binding receptor PDUR_07155 ENOG4108V06 Glutathione peroxidase PDUR_07160 ENOG4108ZHJ Organic hydroperoxide resistance protein PDUR_07175 ENOG4105EHG Permease protein PDUR_07190 ENOG4105KIR Thiol-disulfide oxidoreductase dcc PDUR_07250 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) PDUR_07255 ENOG4105CIY formyltetrahydrofolate deformylase PDUR_07330 ENOG4105NBK UPF0345 protein PDUR_07340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PDUR_07350 ENOG4107QYV phosphohexose isomerase PDUR_07355 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein PDUR_07360 ENOG4108IG5 Transcriptional regulator PDUR_07365 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme PDUR_07370 ENOG4108I5D sulfate abc transporter PDUR_07375 ENOG4105ECW sulfate abc transporter PDUR_07385 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein PDUR_07390 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) PDUR_07400 ENOG4108JE9 extracellular solute-binding protein family 1 PDUR_07405 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PDUR_07410 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component PDUR_07415 ENOG4105DU0 nucleoside hydrolase PDUR_07440 ENOG4105CHR reductase PDUR_07445 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) PDUR_07450 ENOG4105D01 (LipO)protein PDUR_07465 ENOG4108UMI ABC transporter, permease PDUR_07470 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) PDUR_07475 ENOG410667J hydrolase PDUR_07485 ENOG4105C2F Histidine kinase PDUR_07490 ENOG4108VAC response regulator PDUR_07515 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) PDUR_07525 ENOG4105DF9 Lipoate-protein, ligase PDUR_07550 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_07555 ENOG4105DC7 peptidase M24 PDUR_07560 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) PDUR_07565 ENOG4107TCE N-acetyltransferase PDUR_07570 ENOG4105KVH Transcriptional regulator PDUR_07595 ENOG4105KD7 acetyltransferase PDUR_07600 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 PDUR_07620 ENOG4105CJ2 (LipO)protein PDUR_07630 ENOG4107ZXU DSBA oxidoreductase PDUR_07645 ENOG4105C9U ATP-dependent DNA helicase RecQ PDUR_07650 ENOG4107G43 radical SAM domain protein PDUR_07675 ENOG4105DG6 mannose-6-phosphate isomerase PDUR_07685 ENOG4105N5T Radical SAM Protein PDUR_07690 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) PDUR_07705 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) PDUR_07710 ENOG41084BS 50S ribosomal protein L35 PDUR_07715 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) PDUR_07720 ENOG4108S4H thioesterase Superfamily protein PDUR_07725 ENOG4105DIH basic membrane PDUR_07730 ENOG4108JQ9 ABC transporter PDUR_07735 ENOG4105UIB (ABC) transporter PDUR_07755 ENOG4105C7K acetolactate synthase PDUR_07760 ENOG4108ZP8 Acetolactate synthase small subunit PDUR_07765 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase PDUR_07770 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) PDUR_07795 ENOG4105CPC Aldo Keto reductase PDUR_07800 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) PDUR_07805 ENOG4105D3R alkyl hydroperoxide reductase PDUR_07815 ENOG4105BZU Histidine kinase PDUR_07835 ENOG4105BZU Histidine kinase PDUR_07845 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PDUR_07870 ENOG4105C5H ABC transporter PDUR_07880 ENOG4105KWG Pfam:DUF1696 PDUR_07885 ENOG4105FGV Chromate PDUR_07890 ENOG4105CAH Chromate PDUR_07895 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) PDUR_07900 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) PDUR_07905 ENOG4105G9B Transcriptional regulator PDUR_07910 ENOG4105XRQ Xanthine dehydrogenase accessory factor PDUR_07925 ENOG4108JQ9 ABC transporter PDUR_07930 ENOG4105UIB (ABC) transporter PDUR_07945 ENOG4105VT2 5-hydroxyisourate hydrolase PDUR_07950 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) PDUR_07955 ENOG4105CE7 Amidase, hydantoinase carbamoylase family PDUR_07960 ENOG4105C5R Aminotransferase PDUR_07965 ENOG4105CPN adenine deaminase PDUR_07975 ENOG4105EQI Metal Dependent Phosphohydrolase PDUR_08000 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PDUR_08005 ENOG4108WYP Transcriptional regulator PDUR_08010 ENOG41079KZ Major Facilitator Superfamily PDUR_08015 ENOG4108WAV Transcriptional regulator PDUR_08025 ENOG4107FKK extracellular solute-binding protein family 1 PDUR_08035 ENOG4105EG2 ABC transporter, permease PDUR_08040 ENOG4108WYP Transcriptional regulator PDUR_08060 ENOG4108UAU isochorismatase PDUR_08105 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein PDUR_08110 ENOG4105CNU cell division protein FtsK PDUR_08115 ENOG4105DYS nad(p)h dehydrogenase (quinone) PDUR_08125 ENOG4105E98 transcriptional regulator DeoR family PDUR_08130 ENOG410667J hydrolase PDUR_08150 ENOG41089UC methyltransferase, type 11 PDUR_08160 ENOG4105C0D helicase PDUR_08165 ENOG4105ID8 Transcriptional regulator, ARAC family PDUR_08170 ENOG4105CG3 alpha amylase, catalytic region PDUR_08175 ENOG4105C5Y PTS System PDUR_08185 ENOG4105F6U Short-chain dehydrogenase reductase Sdr PDUR_08205 ENOG4105CB2 alcohol dehydrogenase PDUR_08215 ENOG4105E90 ABC transporter PDUR_08225 ENOG4108IJ8 ABC transporter PDUR_08240 ENOG4105CGP Urocanate hydratase PDUR_08250 ENOG4105C84 Histidine ammonia-lyase PDUR_08265 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) PDUR_08270 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) PDUR_08275 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component PDUR_08280 ENOG4105I1K ABC transporter PDUR_08290 ENOG4105C2F Histidine kinase PDUR_08295 ENOG410874W AraC family transcriptional regulator PDUR_08310 ENOG4105F27 Major Facilitator PDUR_08325 ENOG4105F6U Short-chain dehydrogenase reductase Sdr PDUR_08345 ENOG4105X3H Excalibur domain protein PDUR_08365 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PDUR_08425 ENOG4105CG3 alpha amylase, catalytic region PDUR_08465 ENOG4107S6X Glycosyl transferase, family 2 PDUR_08485 ENOG4105ETE Transcriptional regulator (LacI family PDUR_08490 ENOG4108JE9 extracellular solute-binding protein family 1 PDUR_08530 ENOG4105CV8 reductase PDUR_08535 ENOG4105C5I Dehydrogenase PDUR_08540 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) PDUR_08550 ENOG4105ETD TRANSCRIPTIONal PDUR_08575 ENOG41090VF Stage v sporulation protein ac PDUR_08580 ENOG4105CZ3 stage V sporulation protein ad PDUR_08595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 PDUR_08610 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase PDUR_08615 ENOG4105CQW ribosome biogenesis GTPase YqeH PDUR_08620 ENOG4105E2X shikimate dehydrogenase PDUR_08625 ENOG410812S Rna-binding protein PDUR_08630 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) PDUR_08635 ENOG4108WF2 Metal Dependent Phosphohydrolase PDUR_08640 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) PDUR_08645 ENOG4105QNR S1 RNA binding domain protein PDUR_08650 ENOG4105DXX methyltransferase PDUR_08665 ENOG4105DY9 regulatoR PDUR_08670 ENOG4105C2F Histidine kinase PDUR_08685 ENOG41075H3 AraC family transcriptional regulator PDUR_08695 ENOG4105CHM Aminotransferase PDUR_08705 ENOG4105CIG ABC transporter PDUR_08710 ENOG4108RZE Tetr family transcriptional regulator PDUR_08715 ENOG4105C9Q fumarate hydratase class II PDUR_08720 ENOG4105EG2 ABC transporter, permease PDUR_08730 ENOG4105WEF catalase PDUR_08735 ENOG4105CGH 5'-nucleotidase PDUR_08745 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate PDUR_08755 ENOG4106KNT transcriptional regulator PDUR_08770 ENOG4105DRS transport system, permease PDUR_08790 ENOG4105D17 glycoside hydrolase, family 3 domain protein PDUR_08795 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) PDUR_08825 ENOG4108RCM Nitroreductase PDUR_08845 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase PDUR_08865 ENOG4105E1F short-chain dehydrogenase reductase PDUR_08875 ENOG4105D9P serine threonine protein kinase PDUR_08880 ENOG4105CD3 dihydroorotase PDUR_08885 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease PDUR_08920 ENOG4105KBJ sporulation protein ytfj PDUR_08950 ENOG4107EEY synthase PDUR_09035 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) PDUR_09045 ENOG4105VBH UPF0297 protein PDUR_09055 ENOG4105VGP UPF0473 protein PDUR_09065 ENOG4105HHA aminodeoxychorismate lyase PDUR_09070 ENOG4105XYU peptidase (U32 family) PDUR_09075 ENOG4105CFP Peptidase U32 PDUR_09080 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_09085 ENOG4107XRG penicillin-binding protein PDUR_09105 ENOG4105C01 Dihydroxy-acid dehydratase PDUR_09120 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) PDUR_09135 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) PDUR_09140 ENOG4105CMR udp-glucose 4-epimerase PDUR_09145 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase PDUR_09150 ENOG4107QW4 alcohol dehydrogenase PDUR_09155 ENOG4105D60 lipoprotein releasing system transmembrane protein PDUR_09160 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PDUR_09165 ENOG4105BZU Histidine kinase PDUR_09170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PDUR_09180 ENOG4105DZ6 Band 7 protein PDUR_09195 ENOG4105CID antiterminator PDUR_09205 ENOG4105KRI phosphocarrier protein (HPr PDUR_09210 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) PDUR_09225 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) PDUR_09255 ENOG4105C98 muts2 protein PDUR_09280 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) PDUR_09295 ENOG4108ZB6 transcriptional regulator AsnC family PDUR_09300 ENOG4105CHM Aminotransferase PDUR_09315 ENOG4108WBT adenosyltransferase PDUR_09320 ENOG4105EMS pseudouridine synthase PDUR_09325 ENOG41080E8 Transcriptional regulator, Spx MgsR family PDUR_09340 ENOG4105EVU fructokinase PDUR_09350 ENOG4105D7N magnesium and cobalt transport protein CorA PDUR_09360 ENOG4105CVG Homoserine O-transsuccinylase PDUR_09365 ENOG4105C28 cystathionine PDUR_09370 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) PDUR_09395 ENOG4105C22 threonyL-tRNA synthetase PDUR_09400 ENOG41069ER domain protein PDUR_09415 ENOG4105ENE Histidine kinase PDUR_09420 ENOG4105WH1 Two component transcriptional regulator luxr family PDUR_09425 ENOG4105C0H protease PDUR_09430 ENOG4105ETX regulatoR PDUR_09435 ENOG41062D9 Histidine kinase PDUR_09440 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) PDUR_09445 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase PDUR_09450 ENOG4105C5F glutamine synthetase PDUR_09460 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) PDUR_09490 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PDUR_09500 ENOG4105CYN Serine protein kinase PDUR_09510 ENOG4105ED1 spovr family PDUR_09520 ENOG4105EPR degv family PDUR_09525 ENOG41086D8 Transcriptional regulator PDUR_09535 ENOG4107URF beta-phospho-glucomutase PDUR_09540 ENOG4105FKQ transcriptional regulator PDUR_09550 ENOG4105EFZ amidohydrolase PDUR_09565 ENOG4105M08 Membrane PDUR_09575 ENOG4105KZD Domain of unknown function (DUF1805) PDUR_09580 ENOG4108RMU ferritin dps family protein PDUR_09590 ENOG4105C3K feS assembly ATPase SufC PDUR_09595 ENOG4105JRK feS assembly protein SufD PDUR_09605 ENOG4108UNV SUF system FeS assembly protein, NifU family PDUR_09610 ENOG4105DIW FeS assembly protein SUFB PDUR_09625 ENOG4105BZ1 (ABC) transporter PDUR_09630 ENOG4105BZ1 (ABC) transporter PDUR_09640 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) PDUR_09650 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PDUR_09655 ENOG4108ZAF Molybdopterin PDUR_09660 ENOG4107R8B 5'-nucleotidase PDUR_09670 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PDUR_09680 ENOG4105C37 (CBS) domain PDUR_09695 ENOG4105WEF catalase PDUR_09705 ENOG4105KRN Transcriptional regulator, abrb family PDUR_09720 ENOG410839P PDUR_09730 ENOG410839P PDUR_09735 ENOG4105WZB UPF0342 protein PDUR_09780 ENOG4105VV2 PDUR_09785 ENOG4105C0B DNA polymerase III (alpha subunit) PDUR_09800 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) PDUR_09805 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) PDUR_09810 ENOG4105CA9 Pyruvate kinase PDUR_09820 ENOG4105FS0 cytoplasmic membrane protein PDUR_09825 ENOG4108REF Sporulation integral membrane protein ytvi PDUR_09830 ENOG4105BZN citrate synthase PDUR_09835 ENOG4108HMX isocitrate dehydrogenase (NADP) PDUR_09855 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) PDUR_09865 ENOG4105D06 uba thif-type nad fad binding protein PDUR_09870 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) PDUR_09875 ENOG4105D41 biosynthesis protein thiH PDUR_09885 ENOG4105BZU Histidine kinase PDUR_09890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PDUR_09900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) PDUR_09905 ENOG4108UTW Plays a role in the regulation of phosphate uptake PDUR_09915 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) PDUR_09925 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) PDUR_09930 ENOG4105E4C Lytic transglycosylase catalytic PDUR_09940 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) PDUR_09960 ENOG4105EWU Squalene--hopene cyclase PDUR_09970 ENOG4105YA8 Transcriptional regulator PDUR_09985 ENOG4107Z3H Transcriptional regulator, TetR family PDUR_09990 ENOG41069DP small acid-soluble spore protein PDUR_10000 ENOG4105BZU Histidine kinase PDUR_10010 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PDUR_10015 ENOG4105CPQ Dehydrogenase PDUR_10035 ENOG4108XIC integral membrane protein PDUR_10045 ENOG4107S1E Beta-lactamase PDUR_10070 ENOG4108RYK Nad-dependent epimerase dehydratase PDUR_10075 ENOG4106XGU PDUR_10100 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) PDUR_10105 ENOG4105E4R Precorrin-3B C17-methyltransferase PDUR_10110 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein PDUR_10115 ENOG4108JTQ reductase PDUR_10120 ENOG41081F0 Precorrin-8x methylmutase PDUR_10125 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) PDUR_10130 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase PDUR_10135 ENOG4105DVK Precorrin-2 c20-methyltransferase PDUR_10140 ENOG4105CIA precorrin-4 C(11)-methyltransferase PDUR_10145 ENOG4108P62 biosynthesis protein (CbiG) PDUR_10150 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) PDUR_10155 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase PDUR_10160 ENOG4108YZT Adenosylcobinamide kinase PDUR_10165 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) PDUR_10170 ENOG4105GN9 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) PDUR_10185 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) PDUR_10190 ENOG4108IG5 Transcriptional regulator PDUR_10210 ENOG4108NEV two component transcriptional regulator, LytTR family PDUR_10260 ENOG4105CPC Aldo Keto reductase PDUR_10265 ENOG4105GZI Transcriptional regulator PDUR_10270 ENOG4107RT3 EamA-like transporter family PDUR_10275 ENOG4108IUW ABC transporter PDUR_10290 ENOG4105CPK Glycosyl transferase (Group 1 PDUR_10320 ENOG4105CG3 alpha amylase, catalytic region PDUR_10340 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr PDUR_10360 ENOG4105E1J oxidoreductase PDUR_10380 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_10440 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PDUR_10445 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PDUR_10450 ENOG4108EQA pts system PDUR_10455 ENOG4108EQA pts system PDUR_10460 ENOG4105ETZ PTS System PDUR_10465 ENOG4105F3R pts system mannose fructose sorbose family iid PDUR_10480 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component PDUR_10485 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component PDUR_10490 ENOG4105BZ7 extracellular solute-binding protein family 1 PDUR_10500 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PDUR_10515 ENOG4108DBC nitroreductase PDUR_10520 ENOG4105DUM transcriptional regulator, lysR family PDUR_10555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) PDUR_10585 ENOG4105ZMH deoxynucleoside kinase PDUR_10600 ENOG4105C57 major facilitator superfamily PDUR_10620 ENOG4108HRK Histidine kinase PDUR_10630 ENOG4108HKT sucrose-6-phosphate hydrolase PDUR_10640 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PDUR_10645 ENOG4105DRS transport system, permease PDUR_10650 ENOG4105D7K pfkb domain protein PDUR_10660 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_10675 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase PDUR_10680 ENOG4105EQ0 Major Facilitator superfamily PDUR_10685 ENOG4108JGH Tetr family transcriptional regulator PDUR_10715 ENOG4105D7V transposase PDUR_10725 ENOG4108KB2 LysR family Transcriptional regulator PDUR_10730 ENOG4105MDS 4-oxalocrotonate tautomerase PDUR_10750 ENOG4105ENE Histidine kinase PDUR_10755 ENOG4108VB1 regulatoR PDUR_10765 ENOG4105EYF MMPL domain protein PDUR_10770 ENOG4105ECQ AraC Family Transcriptional Regulator PDUR_10785 ENOG4107SET aldo keto reductase PDUR_10810 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) PDUR_10850 ENOG4108PJD permease PDUR_10855 ENOG4105CKI cobalamin synthesis protein PDUR_10860 ENOG4105CKI cobalamin synthesis protein PDUR_10905 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) PDUR_10925 ENOG4105QAT UPF0741 protein PDUR_10935 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) PDUR_10950 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) PDUR_10955 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) PDUR_10960 ENOG4105C1Q protoporphyrinogen oxidase PDUR_10965 ENOG4105PNM synthesis protein PDUR_10970 ENOG4107VXM glycerophosphoryl diester phosphodiesterase PDUR_10985 ENOG4105C5H ABC transporter PDUR_10990 ENOG4105C87 Aminotransferase class I and II PDUR_10995 ENOG4105DER m42 family PDUR_11000 ENOG41067VP Protein of unknown function (DUF1049) PDUR_11005 ENOG4105DPN Oligoendopeptidase f PDUR_11020 ENOG4105VEQ Cold shock protein PDUR_11045 ENOG4105XTG Pfam:DUF156 PDUR_11050 ENOG4107QMU Mate efflux family protein PDUR_11065 ENOG4105C1J atp-dependent rna helicase PDUR_11080 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) PDUR_11090 ENOG4105C5Q Transcriptional regulator PDUR_11125 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PDUR_11130 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) PDUR_11135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) PDUR_11145 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein PDUR_11155 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) PDUR_11170 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B PDUR_11180 ENOG410667J hydrolase PDUR_11185 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B PDUR_11190 ENOG4108I69 Glycosyl transferases group 1 PDUR_11200 ENOG4106D4I domain protein PDUR_11205 ENOG4108K88 Membrane PDUR_11210 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) PDUR_11260 ENOG4108151 Beta-lactamase domain protein PDUR_11270 ENOG4107QKG PfaD family PDUR_11275 ENOG4105C0W non-ribosomal peptide synthetase PDUR_11300 ENOG4107SQU synthase PDUR_11325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PDUR_11350 ENOG4105DEN Luciferase family PDUR_11355 ENOG4105F27 Major Facilitator PDUR_11360 ENOG4105KVH Transcriptional regulator PDUR_11380 ENOG4105CV8 reductase PDUR_11400 ENOG4105DCT glycerol dehydrogenase PDUR_11405 ENOG4105C87 Aminotransferase class I and II PDUR_11420 ENOG4107S1E Beta-lactamase PDUR_11425 ENOG4105F27 Major Facilitator PDUR_11430 ENOG4105WAB arsR family transcriptional regulator PDUR_11510 ENOG4108ZMX Domain of unknown function (DU1801) PDUR_11515 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) PDUR_11540 ENOG4107QKG PfaD family PDUR_11565 ENOG4105C3S Mate efflux family protein PDUR_11600 ENOG4105D94 Major Facilitator Superfamily PDUR_11610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PDUR_11640 ENOG4105BZ1 (ABC) transporter PDUR_11650 ENOG4108FN7 Aldo keto reductase PDUR_11710 ENOG4105DGU Histone deacetylase PDUR_11720 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component PDUR_11730 ENOG4107QK4 glycoside hydrolase, family 3 domain protein PDUR_11740 ENOG4105F27 Major Facilitator PDUR_11745 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PDUR_11760 ENOG4105D0B Nitrogenase protein alpha chain PDUR_11765 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN PDUR_11790 ENOG4105D0B Nitrogenase protein alpha chain PDUR_11800 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain PDUR_11805 ENOG4105D0B Nitrogenase protein alpha chain PDUR_11810 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) PDUR_11815 ENOG4107SDT Homocitrate synthase PDUR_11820 ENOG4107SDT Homocitrate synthase PDUR_11825 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family PDUR_11830 ENOG4105EHG Permease protein PDUR_11835 ENOG4105E0A ABC, transporter PDUR_11860 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN PDUR_11870 ENOG4107SDT Homocitrate synthase PDUR_11875 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) PDUR_11890 ENOG4105CG3 alpha amylase, catalytic region PDUR_11895 ENOG4105C5Y PTS System PDUR_11900 ENOG4107414 GntR family transcriptional regulator PDUR_11905 ENOG4105BZ1 (ABC) transporter PDUR_11915 ENOG4105JFG SpoIID LytB domain protein PDUR_11935 ENOG4105DA5 (ABC) transporter PDUR_11975 ENOG4108R66 Conserved Protein PDUR_11980 ENOG4108R66 Conserved Protein PDUR_11990 ENOG4105CHR reductase PDUR_11995 ENOG4105C5I Dehydrogenase PDUR_12005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_12010 ENOG4105BZU Histidine kinase PDUR_12020 ENOG4105P4J Allophanate hydrolase, subunit 1 PDUR_12030 ENOG4105E7W lamb ycsf family protein PDUR_12050 ENOG4105C2F Histidine kinase PDUR_12055 ENOG4105EQD regulatoR PDUR_12060 ENOG4105C4Y ABC transporter PDUR_12065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PDUR_12070 ENOG4107RCV ABC transporter, permease PDUR_12095 ENOG4105E1F short-chain dehydrogenase reductase PDUR_12110 ENOG4105C31 Tryptophanyl-tRNA synthetase PDUR_12130 ENOG4107Z3H Transcriptional regulator, TetR family PDUR_12155 ENOG4105C6T cysteine synthase PDUR_12175 ENOG4106P55 Transcriptional regulator PDUR_12180 ENOG4105BZ1 (ABC) transporter PDUR_12185 ENOG4105BZ1 (ABC) transporter PDUR_12210 ENOG4108TVJ Nitroreductase PDUR_12230 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) PDUR_12235 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) PDUR_12245 ENOG4108Z40 Transcriptional regulator PDUR_12250 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) PDUR_12255 ENOG4105EEQ Na H antiporter PDUR_12270 ENOG4105DWK Membrane PDUR_12275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) PDUR_12290 ENOG4108VD1 dedA family PDUR_12295 ENOG4105EMN RNA polymerase sigma factor PDUR_12310 ENOG4105EQD regulatoR PDUR_12315 ENOG4108HRK Histidine kinase PDUR_12325 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component PDUR_12330 ENOG4105I1K ABC transporter PDUR_12380 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes PDUR_12385 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_12395 ENOG4108UW5 maltose o-acetyltransferase PDUR_12440 ENOG4105RK9 auxin efflux carrier PDUR_12450 ENOG41082BV acetyltransferase PDUR_12460 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) PDUR_12475 ENOG4105CXN decarboxylase PDUR_12485 ENOG4108WQ8 UPF0637 protein PDUR_12495 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) PDUR_12500 ENOG4107ZC0 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) PDUR_12505 ENOG41085GJ domain protein PDUR_12510 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase PDUR_12515 ENOG4105K4P CoA-binding domain protein PDUR_12520 ENOG4105CI1 PTS System PDUR_12525 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) PDUR_12530 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein PDUR_12535 ENOG4105JVQ RNA Polymerase PDUR_12545 ENOG4108Z0Z intracellular protease Pfpi family PDUR_12555 ENOG4105ETE Transcriptional regulator (LacI family PDUR_12575 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) PDUR_12580 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) PDUR_12585 ENOG4105BZU Histidine kinase PDUR_12605 ENOG4105ZPI UPF0358 protein PDUR_12610 ENOG4105UPD Calcium Proton PDUR_12615 ENOG4105VBF alkaline shock protein PDUR_12620 ENOG4105CNI cell division protein FtsW PDUR_12635 ENOG41080XQ Signal transduction protein with cbs domains PDUR_12640 ENOG4105CFI type iii restriction protein res subunit PDUR_12670 ENOG4105DUM transcriptional regulator, lysR family PDUR_12680 ENOG4105F23 Fibronectin-binding protein PDUR_12690 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) PDUR_12695 ENOG4105E1K spore germination protein PDUR_12720 ENOG4105DSJ YicC domain protein PDUR_12725 ENOG4105KC4 UPF0296 protein PDUR_12730 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) PDUR_12735 ENOG41067UH Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) PDUR_12745 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase PDUR_12750 ENOG4105C25 Primosomal protein n' PDUR_12755 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) PDUR_12760 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) PDUR_12765 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B PDUR_12770 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs PDUR_12775 ENOG4108ZF3 Phosphatase PDUR_12780 ENOG4105D9P serine threonine protein kinase PDUR_12785 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) PDUR_12790 ENOG4105DJV ribulose-phosphate 3-epimerase PDUR_12800 ENOG4105VB9 50S ribosomal protein l28 PDUR_12805 ENOG4105DP4 dak2 domain fusion protein ylov PDUR_12810 ENOG4105EPR degv family PDUR_12815 ENOG4105CB5 ATP-dependent DNA helicase recG PDUR_12830 ENOG4107S91 Sodium hydrogen exchanger PDUR_12835 ENOG4105NCW Trka-c domain protein PDUR_12850 ENOG41068JE domain protein PDUR_12860 ENOG4105C7J ABC transporter, permease PDUR_12870 ENOG4105KT7 mgtC SapB transporter PDUR_12875 ENOG4108N2V aldose 1-epimerase PDUR_12905 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) PDUR_12915 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) PDUR_12920 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) PDUR_12925 ENOG410841Q phosphoesterase PA-phosphatase related protein PDUR_12930 ENOG4107NBY Membrane PDUR_12935 ENOG4105EEM helicase PDUR_12945 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) PDUR_12965 ENOG4105E66 phosphoriboisomerase A PDUR_12980 ENOG41067TZ transcriptional regulator, MarR family PDUR_12985 ENOG4105EYF MMPL domain protein PDUR_13015 ENOG4108VY7 phosphate-starvation-inducible protein PsiE PDUR_13040 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) PDUR_13045 ENOG4105DWF phosphomethylpyrimidine kinase PDUR_13050 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase PDUR_13060 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_13075 ENOG4105DDN Pentapeptide repeat-containing protein PDUR_13080 ENOG4105F2M alpha beta hydrolase fold-3 domain protein PDUR_13100 ENOG4105I3K Ferric uptake regulator, Fur family PDUR_13105 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions PDUR_13125 ENOG4105CG3 alpha amylase, catalytic region PDUR_13130 ENOG4105DBV ornithine carbamoyltransferase PDUR_13135 ENOG4105ETE Transcriptional regulator (LacI family PDUR_13140 ENOG4107FKK extracellular solute-binding protein family 1 PDUR_13150 ENOG4105EG2 ABC transporter, permease PDUR_13160 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) PDUR_13175 ENOG4105CGK Exodeoxyribonuclease III PDUR_13185 ENOG4108ZGA chew protein PDUR_13190 ENOG4108N3W hemolysin secretion protein PDUR_13195 ENOG41062JF Transcriptional regulator PDUR_13225 ENOG4105DQ5 transport system permease protein PDUR_13230 ENOG4105EHG Permease protein PDUR_13235 ENOG4105EC8 Methyl-accepting chemotaxis PDUR_13255 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b PDUR_13275 ENOG4105C0A alcohol dehydrogenase PDUR_13285 ENOG4108YYS metal-dependent hydrolase (By similarity) PDUR_13300 ENOG4105D0B Nitrogenase protein alpha chain PDUR_13305 ENOG4105D0B Nitrogenase protein alpha chain PDUR_13325 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_13335 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_13340 ENOG4105CIZ coA-substrate-specific enzyme activase PDUR_13355 ENOG4105KKJ Aminoglycoside phosphotransferase PDUR_13365 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PDUR_13370 ENOG4105D7V transposase PDUR_13385 ENOG4107QW4 alcohol dehydrogenase PDUR_13395 ENOG4105C2C drug resistance transporter, Bcr CflA PDUR_13425 ENOG4105BZU Histidine kinase PDUR_13435 ENOG4108I0Q anthranilate phosphoribosyltransferase PDUR_13445 ENOG4108IFG nitrite reductase, (NAD(P)H) PDUR_13450 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit PDUR_13455 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PDUR_13465 ENOG4105CZ9 Domain of unknown function (DU1801) PDUR_13485 ENOG4108RAV Conserved protein PDUR_13495 ENOG41086IN PA14 PDUR_13500 ENOG4105K64 Glycosyl transferase, family 2 PDUR_13505 ENOG4106H78 methyltransferase PDUR_13510 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) PDUR_13520 ENOG41063PX domain protein PDUR_13525 ENOG4105CDE UPF0348 protein PDUR_13535 ENOG41067VY 50S ribosomal protein L32 PDUR_13540 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) PDUR_13545 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) PDUR_13555 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase PDUR_13560 ENOG4105CHR reductase PDUR_13565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) PDUR_13570 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) PDUR_13575 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) PDUR_13585 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) PDUR_13590 ENOG4108RC0 Electron transport protein PDUR_13595 ENOG4107QHI -hydrogenase PDUR_13600 ENOG4108RC0 Electron transport protein PDUR_13605 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PDUR_13610 ENOG4108IJ0 Aspartate ammonia-lyase PDUR_13615 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) PDUR_13625 ENOG4107QW8 radical SAM domain protein PDUR_13630 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) PDUR_13635 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) PDUR_13640 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) PDUR_13660 ENOG4105H9W Short-chain dehydrogenase reductase Sdr PDUR_13665 ENOG4105VTS DnaJ-like, subfamily C PDUR_13670 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) PDUR_13675 ENOG4105CQ7 ATP-dependent helicase PDUR_13695 ENOG4105BZU Histidine kinase PDUR_13705 ENOG4107R13 MMPL domain protein PDUR_13725 ENOG4107RBI VanW family PDUR_13740 ENOG4107V2S Transcriptional regulator PDUR_13745 ENOG4105CVA phosphate PDUR_13750 ENOG4105C8U phosphate abc transporter PDUR_13755 ENOG4105E2Z phosphate ABC transporter (Permease PDUR_13760 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) PDUR_13765 ENOG4108W8B Beta-lactamase domain protein PDUR_13785 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) PDUR_13805 ENOG4105CZN Potassium uptake protein PDUR_13825 ENOG4105C37 (CBS) domain PDUR_13835 ENOG41079KZ Major Facilitator Superfamily PDUR_13840 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) PDUR_13855 ENOG4107QRT dEAD DEAH box helicase PDUR_13860 ENOG4107S21 permease PDUR_13865 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) PDUR_13870 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) PDUR_13900 ENOG4105C59 p-type ATPase PDUR_13915 ENOG4108PK2 permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence PDUR_13925 ENOG4105GFR rna polymerase sigma factor PDUR_13945 ENOG4105C4X radical SAM domain protein PDUR_13955 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PDUR_13960 ENOG4105C4B ABC transporter, permease PDUR_13980 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) PDUR_14000 ENOG4108IUW ABC transporter PDUR_14020 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PDUR_14025 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) PDUR_14040 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit PDUR_14045 ENOG41080XS Cobyrinic acid ac-diamide synthase PDUR_14075 ENOG41089UC methyltransferase, type 11 PDUR_14095 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PDUR_14100 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) PDUR_14110 ENOG4108151 Beta-lactamase domain protein PDUR_14115 ENOG4108JA1 polyketide synthase PDUR_14120 ENOG4107QKG PfaD family PDUR_14125 ENOG41062T2 Acyl carrier protein PDUR_14130 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase PDUR_14135 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase PDUR_14145 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PDUR_14150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PDUR_14170 ENOG4107SQU synthase PDUR_14175 ENOG4105C0W non-ribosomal peptide synthetase PDUR_14215 ENOG4105NAE bifunctional deaminase-reductase domain protein PDUR_14235 ENOG4105X5K response regulator receiver protein PDUR_14240 ENOG4105CF7 AraC family transcriptional regulator PDUR_14270 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PDUR_14275 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) PDUR_14285 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_14295 ENOG4105DEG Vwa containing coxe family protein PDUR_14305 ENOG4105KKX ATPase associated with various cellular activities aaa_5 PDUR_14325 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein PDUR_14330 ENOG4105WAB arsR family transcriptional regulator PDUR_14340 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) PDUR_14355 ENOG4105X5K response regulator receiver protein PDUR_14365 ENOG4105C5H ABC transporter PDUR_14380 ENOG4108QEG Membrane PDUR_14405 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) PDUR_14410 ENOG4105F1A Pyruvate formate-lyase PDUR_14415 ENOG4105C6N Formate acetyltransferase PDUR_14435 ENOG4105JVQ RNA Polymerase PDUR_14480 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) PDUR_14495 ENOG4108Z40 Transcriptional regulator PDUR_14520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) PDUR_14545 ENOG4105DU0 nucleoside hydrolase PDUR_14555 ENOG4105CB2 alcohol dehydrogenase PDUR_14560 ENOG4105KVH Transcriptional regulator PDUR_14575 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) PDUR_14580 ENOG4105D0B Nitrogenase protein alpha chain PDUR_14610 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) PDUR_14630 ENOG41067SE Tetr family transcriptional regulator PDUR_14635 ENOG4106AXJ AraC family transcriptional regulator PDUR_14640 ENOG410631K Membrane PDUR_14655 ENOG4105BZU Histidine kinase PDUR_14660 ENOG4105EFI regulatoR PDUR_14665 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) PDUR_14670 ENOG4105C19 ABC transporter PDUR_14675 ENOG4105CW7 secretion protein, HlyD family PDUR_14690 ENOG4108HKT sucrose-6-phosphate hydrolase PDUR_14695 ENOG4105EDQ levansucrase EC 2.4.1.10 PDUR_14700 ENOG4105EDQ levansucrase EC 2.4.1.10 PDUR_14715 ENOG4105U0R haloacid dehalogenase-like hydrolase PDUR_14745 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) PDUR_14795 ENOG4107ZBH radical SAM domain protein PDUR_14805 ENOG4107T7U Sulfatase PDUR_14810 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) PDUR_14820 ENOG4105CI2 imidazolone-5-propionate hydrolase PDUR_14830 ENOG4105C84 Histidine ammonia-lyase PDUR_14835 ENOG4105CIH Imidazole acetol-phosphate transaminase PDUR_14840 ENOG4107XGZ Hydrolase PDUR_14850 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) PDUR_14855 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) PDUR_14880 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) PDUR_14885 ENOG4105F27 Major Facilitator PDUR_14895 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) PDUR_14900 ENOG4105DWF phosphomethylpyrimidine kinase PDUR_14905 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) PDUR_14910 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase PDUR_14915 ENOG4105DVM PP-loop domain protein PDUR_14920 ENOG4105C8M UPF0272 protein PDUR_14930 ENOG4105VUF Transcriptional regulator PDUR_14935 ENOG4105D2M Aldolase PDUR_14945 ENOG4105DVE abc transporter atp-binding protein PDUR_14950 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family PDUR_14960 ENOG4105DIN metallophosphoesterase PDUR_14965 ENOG4105CHR reductase PDUR_14970 ENOG4105NF4 modulator of drug activity PDUR_14980 ENOG410828M hemerythrin-like, metal-binding protein PDUR_14985 ENOG4105DCM major facilitator superfamily PDUR_14990 ENOG4105CHR reductase PDUR_14995 ENOG4108IND Tetr family transcriptional regulator PDUR_15005 ENOG4105H67 Protein of unknown function (DUF421) PDUR_15020 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_15035 ENOG4105CNI cell division protein FtsW PDUR_15055 ENOG4108JJB ABC transporter PDUR_15060 ENOG4108JJB ABC transporter PDUR_15065 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) PDUR_15080 ENOG4108IUW ABC transporter PDUR_15085 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) PDUR_15090 ENOG4105KVH Transcriptional regulator PDUR_15105 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) PDUR_15110 ENOG4108I0Y (ABC) transporter PDUR_15120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_15130 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) PDUR_15135 ENOG4105D2X ABC transporter substrate-binding protein PDUR_15145 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component PDUR_15150 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) PDUR_15155 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase PDUR_15160 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) PDUR_15165 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) PDUR_15180 ENOG4108A65 Transcriptional regulator PDUR_15185 ENOG4107XZQ multidrug resistance protein PDUR_15210 ENOG4105C0X amino acid PDUR_15220 ENOG4108R9S DSBA oxidoreductase PDUR_15225 ENOG4105C37 (CBS) domain PDUR_15235 ENOG4108VKI Cell wall hydrolase PDUR_15255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) PDUR_15260 ENOG4108R1P PDUR_15265 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_15270 ENOG4107V2S Transcriptional regulator PDUR_15305 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) PDUR_15310 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin PDUR_15320 ENOG4105D29 Helix-turn-helix type 11 domain protein PDUR_15325 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) PDUR_15335 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) PDUR_15350 ENOG4105E5W Transporter PDUR_15355 ENOG4105KVH Transcriptional regulator PDUR_15360 ENOG4105CV8 reductase PDUR_15375 ENOG4105Y7M Transcriptional regulator, TetR family PDUR_15395 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b PDUR_15400 ENOG4105CVM Molybdenum cofactor synthesis domain protein PDUR_15410 ENOG41087YS Phage shock protein A PDUR_15420 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) PDUR_15425 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) PDUR_15435 ENOG41069ER domain protein PDUR_15440 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) PDUR_15455 ENOG4105C1B dTDP-glucose 4-6-dehydratase PDUR_15470 ENOG4107T8Q Glycosyl transferase (Group 1 PDUR_15495 ENOG4105CDA abc transporter atp-binding protein PDUR_15500 ENOG4105EAD ABC transporter PDUR_15505 ENOG4108HW3 (ABC) transporter PDUR_15515 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) PDUR_15525 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) PDUR_15540 ENOG4105BZU Histidine kinase PDUR_15545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_15555 ENOG4105D5T phosphonate abc transporter PDUR_15560 ENOG4105YVS arsR family transcriptional regulator PDUR_15570 ENOG4107ZQN disulfide bond PDUR_15575 ENOG4105C9U ATP-dependent DNA helicase RecQ PDUR_15585 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) PDUR_15590 ENOG4105BZ8 glutamate synthase PDUR_15595 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) PDUR_15630 ENOG4105KJF protein tyrosine phosphatase PDUR_15635 ENOG4105FJ0 thiamine PDUR_15640 ENOG4107TT5 NLP P60 protein PDUR_15650 ENOG4105D06 uba thif-type nad fad binding protein PDUR_15655 ENOG4105C5H ABC transporter PDUR_15660 ENOG4105D9P serine threonine protein kinase PDUR_15665 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) PDUR_15685 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) PDUR_15695 ENOG4105D4U had-superfamily hydrolase, subfamily iia PDUR_15700 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) PDUR_15705 ENOG4105C3R Methionine synthase PDUR_15715 ENOG4105U0R haloacid dehalogenase-like hydrolase PDUR_15725 ENOG4105VPS UPF0291 protein PDUR_15735 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) PDUR_15740 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein PDUR_15750 ENOG4105C5F glutamine synthetase PDUR_15755 ENOG4105KV4 Transcriptional regulator PDUR_15760 ENOG4105CXI aluminum resistance protein PDUR_15770 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) PDUR_15775 ENOG4106F1P AAA ATPase, central domain protein PDUR_15795 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) PDUR_15800 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) PDUR_15805 ENOG4107YX5 Pfam:DUF548 PDUR_15810 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) PDUR_15815 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) PDUR_15835 ENOG4108QEG Membrane PDUR_15840 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component PDUR_15850 ENOG4105D2X ABC transporter substrate-binding protein PDUR_15905 ENOG4105KTU Transcriptional regulator, arsr family PDUR_15910 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase PDUR_15915 ENOG4108VMM UPF0756 membrane protein PDUR_15935 ENOG4105BZ1 (ABC) transporter PDUR_15940 ENOG4105BZ1 (ABC) transporter PDUR_15955 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding PDUR_15960 ENOG4105CKI cobalamin synthesis protein PDUR_15965 ENOG4105EPU Molybdenum cofactor synthesis domain protein PDUR_15980 ENOG4108IUW ABC transporter PDUR_15990 ENOG4105D0B Nitrogenase protein alpha chain PDUR_15995 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) PDUR_16005 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB PDUR_16010 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) PDUR_16020 ENOG4105DAP Nicotinate phosphoribosyltransferase PDUR_16035 ENOG4105W8Z 4'-phosphopantetheinyl transferase PDUR_16050 ENOG4105UQX Mate efflux family protein PDUR_16060 ENOG4105C0W non-ribosomal peptide synthetase PDUR_16075 ENOG4105C1G acyl-Coa dehydrogenase PDUR_16080 ENOG4105CAQ asparagine synthetase PDUR_16085 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein PDUR_16110 ENOG4105BZJ Electron transfer flavoprotein PDUR_16120 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) PDUR_16125 ENOG4108Z66 YbaK ebsC protein PDUR_16135 ENOG4105DEU major facilitator superfamily PDUR_16140 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) PDUR_16145 ENOG4108IGT Dipeptidase PDUR_16150 ENOG4105MCT stage V sporulation protein S PDUR_16155 ENOG4105D48 metallophosphoesterase PDUR_16160 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) PDUR_16170 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) PDUR_16180 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PDUR_16185 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) PDUR_16215 ENOG4108RKS Short-chain dehydrogenase reductase Sdr PDUR_16240 ENOG4105CNU cell division protein FtsK PDUR_16255 ENOG4105CN5 Metallo-Beta-Lactamase PDUR_16260 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PDUR_16270 ENOG4108S0H Dipicolinic acid synthetase, b subunit PDUR_16275 ENOG4105E35 Dipicolinate synthase subunit A PDUR_16280 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) PDUR_16285 ENOG4105C1V Peptidase, M16 PDUR_16295 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) PDUR_16300 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) PDUR_16305 ENOG4105DTN riboflavin biosynthesis protein ribF PDUR_16310 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) PDUR_16315 ENOG4105SFS phosphoesterase RecJ domain protein PDUR_16320 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) PDUR_16325 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) PDUR_16330 ENOG4105VHM ribosomal protein PDUR_16335 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination PDUR_16340 ENOG4105CHV Transcription elongation factor NusA PDUR_16345 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) PDUR_16350 ENOG41075H3 AraC family transcriptional regulator PDUR_16355 ENOG4105DRS transport system, permease PDUR_16360 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component PDUR_16365 ENOG4107T3P ABC, transporter PDUR_16370 ENOG4105C2F Histidine kinase PDUR_16375 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) PDUR_16380 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) PDUR_16385 ENOG4105DZP Membrane-associated zinc metalloprotease PDUR_16390 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) PDUR_16395 ENOG4105KNE Phosphatidate cytidylyltransferase PDUR_16400 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) PDUR_16405 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) PDUR_16410 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) PDUR_16415 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) PDUR_16420 ENOG4105CE9 30S ribosomal protein S2 PDUR_16445 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PDUR_16455 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) PDUR_16465 ENOG4108V3W Chemotaxis protein, CheW PDUR_16470 ENOG4105CBS Chea signal transduction histidine kinase PDUR_16475 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) PDUR_16485 ENOG4105FZW flagellar biosynthesis regulator FlhF PDUR_16490 ENOG4105D7B Flagellar biosynthesis protein flha PDUR_16495 ENOG4105D00 flagellar biosynthetic protein flhB PDUR_16500 ENOG4105D19 Role in flagellar biosynthesis (By similarity) PDUR_16505 ENOG4105VS8 Flagellar biosynthetic protein fliq PDUR_16510 ENOG4105CN7 Flagellar biosynthetic protein FliP PDUR_16520 ENOG4107YTP response regulator receiver protein PDUR_16525 ENOG4105DD5 Flagellar motor switch protein PDUR_16530 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) PDUR_16545 ENOG4108JQA flagellar PDUR_16555 ENOG410822I Flagellar hook capping protein PDUR_16570 ENOG4106YF4 Flagellar biosynthesis chaperone PDUR_16585 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) PDUR_16590 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) PDUR_16595 ENOG4105VQ0 flagellar hook-basal body complex protein fliE PDUR_16600 ENOG4108ZC9 flagellar basal-body rod protein flgc PDUR_16605 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) PDUR_16615 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) PDUR_16620 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) PDUR_16625 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) PDUR_16635 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha PDUR_16640 ENOG4105CMV Succinyl-CoA synthetase subunit beta PDUR_16645 ENOG4105K56 Transcriptional regulator PDUR_16650 ENOG4105C0P Mg chelatase subunit ChlI PDUR_16665 ENOG4105VFF UPF0102 protein PDUR_16680 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) PDUR_16685 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) PDUR_16690 ENOG4105C3F Signal peptidase i PDUR_16695 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) PDUR_16725 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) PDUR_16730 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) PDUR_16740 ENOG4105K5M 30s ribosomal protein S16 PDUR_16750 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) PDUR_16755 ENOG4108UT2 hemolysin iii PDUR_16760 ENOG4105CTD carboxy-peptidase PDUR_16770 ENOG4108V2W Carbonate dehydratase PDUR_16775 ENOG41081VB Hydrolase PDUR_16800 ENOG4105I7V membrAne PDUR_16805 ENOG4105C7Z Conserved Protein PDUR_16810 ENOG4105C7K acetolactate synthase PDUR_16845 ENOG4108JCI Transcriptional regulator PDUR_16855 ENOG4108WC5 Alpha Beta Hydrolase Fold protein PDUR_16885 ENOG4105E66 phosphoriboisomerase A PDUR_16890 ENOG4105DKT Transcriptional regulator PDUR_16910 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_16935 ENOG4105EW9 transcriptional regulator AsnC family PDUR_16945 ENOG4105KK4 UPF0060 membrane protein PDUR_16950 ENOG4105VUC UPF0237 protein PDUR_16955 ENOG4105CAG UPF0210 protein PDUR_16975 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component PDUR_16990 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_16995 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_17000 ENOG4105C0R drug resistance transporter emrb qaca subfamily PDUR_17010 ENOG4108UIN ybak prolyl-trna synthetase associated region PDUR_17040 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) PDUR_17060 ENOG4105NQC Flavodoxin PDUR_17065 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) PDUR_17070 ENOG4105C34 Pseudouridine synthase PDUR_17085 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PDUR_17095 ENOG4105CJ1 ABC, transporter PDUR_17110 ENOG4105K4I Scp-like extracellular PDUR_17140 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR PDUR_17150 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_17160 ENOG4105CSM endonuclease III PDUR_17175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase PDUR_17180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase PDUR_17190 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PDUR_17200 ENOG4105C5Q Transcriptional regulator PDUR_17210 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) PDUR_17215 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) PDUR_17230 ENOG4105C5S asparaginyl-tRNA synthetase PDUR_17235 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) PDUR_17240 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase PDUR_17265 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) PDUR_17270 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) PDUR_17275 ENOG4105DVT helicase PDUR_17285 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) PDUR_17290 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) PDUR_17295 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) PDUR_17310 ENOG4105CPK Glycosyl transferase (Group 1 PDUR_17315 ENOG4105FJR Lmbe family PDUR_17320 ENOG4108Z5K methylglyoxal synthase PDUR_17325 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) PDUR_17335 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase PDUR_17340 ENOG4108JYZ YitT family PDUR_17355 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit PDUR_17360 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) PDUR_17365 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) PDUR_17390 ENOG4105CVJ phosphoglycerate mutase PDUR_17400 ENOG4105EMN RNA polymerase sigma factor PDUR_17410 ENOG4105CIH Imidazole acetol-phosphate transaminase PDUR_17415 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) PDUR_17425 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase PDUR_17430 ENOG4105DK0 Indole-3-glycerol phosphate synthase PDUR_17435 ENOG4108I0Q anthranilate phosphoribosyltransferase PDUR_17440 ENOG4105CRQ synthase (Component I) PDUR_17445 ENOG4105KHN chorismate mutase PDUR_17450 ENOG4105D49 3-dehydroquinate synthase PDUR_17455 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase PDUR_17465 ENOG4105BZU Histidine kinase PDUR_17470 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) PDUR_17485 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase PDUR_17490 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) PDUR_17495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PDUR_17510 ENOG4105WP2 Tryptophan RNA-binding attenuator protein PDUR_17515 ENOG4105K70 DNA-binding protein PDUR_17525 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) PDUR_17555 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase PDUR_17560 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) PDUR_17565 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) PDUR_17570 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) PDUR_17575 ENOG4105F6E Acyl-transferase PDUR_17590 ENOG4105MSI germination protein ypeb PDUR_17600 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) PDUR_17605 ENOG4108S6Z Negative regulator of genetic competence PDUR_17640 ENOG4105CHR reductase PDUR_17650 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) PDUR_17660 ENOG4105BZU Histidine kinase PDUR_17660 ENOG4105BZU Histidine kinase PDUR_17665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_17670 ENOG4105CRE cytochrome C PDUR_17675 ENOG4107TWT Cytochrome c biogenesis protein PDUR_17680 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PDUR_17685 ENOG4105FE9 pseudouridine synthase PDUR_17700 ENOG4108JIC nucleoside recognition domain protein PDUR_17705 ENOG4105DZ1 carboxypeptidase PDUR_17710 ENOG4105KBJ sporulation protein ytfj PDUR_17720 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) PDUR_17725 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) PDUR_17730 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) PDUR_17735 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) PDUR_17740 ENOG4108R6K riboflavin synthase, subunit alpha PDUR_17745 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) PDUR_17755 ENOG4105D1U peptidase U62 modulator of DNA gyrase PDUR_17765 ENOG4107ZE5 PPIases accelerate the folding of proteins PDUR_17770 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) PDUR_17800 ENOG4105EBR Carboxylesterase PDUR_17825 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 PDUR_17835 ENOG4105CAY ferredoxin--nadp reductase PDUR_17840 ENOG41090A1 ferritin PDUR_17850 ENOG4105W8Z 4'-phosphopantetheinyl transferase PDUR_17855 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PDUR_17870 ENOG4105DZ1 carboxypeptidase PDUR_17885 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) PDUR_17895 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) PDUR_17900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_17910 ENOG4105I3K Ferric uptake regulator, Fur family PDUR_17915 ENOG4105MZ9 stage II sporulation protein m PDUR_17935 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) PDUR_17945 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) PDUR_17950 ENOG4105C7S Dehydrogenase PDUR_17960 ENOG4105CPP Dehydrogenase, E1 component PDUR_18000 ENOG4107104 thymidine kinase PDUR_18020 ENOG4105EG2 ABC transporter, permease PDUR_18030 ENOG4107FKK extracellular solute-binding protein family 1 PDUR_18035 ENOG4105ETE Transcriptional regulator (LacI family PDUR_18080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_18110 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase PDUR_18335 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_18340 ENOG4107QQR Sporulation PDUR_18345 ENOG4105S1Z Stage IV sporulation protein B PDUR_18350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) PDUR_18355 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) PDUR_18365 ENOG4105DX0 Hemolysin A PDUR_18370 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) PDUR_18380 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) PDUR_18385 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) PDUR_18390 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) PDUR_18395 ENOG4105M7K Involved in the transcription termination process (By similarity) PDUR_18410 ENOG4108ZSR alkaline shock protein PDUR_18415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase PDUR_18445 ENOG4105KQ4 Stage iii sporulation protein ad PDUR_18450 ENOG4108CQH stage III sporulation protein AC PDUR_18460 ENOG4105CD2 stage iii sporulation protein aa PDUR_18470 ENOG4108JYZ YitT family PDUR_18480 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) PDUR_18485 ENOG4105DC7 peptidase M24 PDUR_18495 ENOG4105CBJ Metal-dependent enzyme PDUR_18510 ENOG4105F32 YngK protein PDUR_18515 ENOG4105KST dependent repressor PDUR_18520 ENOG4107QIV Cytochrome c biogenesis protein PDUR_18530 ENOG4105FDK ABC transporter PDUR_18540 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) PDUR_18545 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) PDUR_18550 ENOG4105N80 Ferric uptake regulator, Fur family PDUR_18565 ENOG4105F1A Pyruvate formate-lyase PDUR_18575 ENOG4108EKI Dehydrogenase PDUR_18580 ENOG4107V6Q Cyclic nucleotide-binding domain PDUR_18585 ENOG4107V9H nitrite transporter PDUR_18590 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit PDUR_18595 ENOG4108IFG nitrite reductase, (NAD(P)H) PDUR_18600 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) PDUR_18615 ENOG41087PP glycosyltransferase MGT family PDUR_18620 ENOG41087PP glycosyltransferase MGT family PDUR_18640 ENOG4105E0X reductase PDUR_18655 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) PDUR_18660 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) PDUR_18665 ENOG4105D9P serine threonine protein kinase PDUR_18675 ENOG4108JYZ YitT family PDUR_18690 ENOG4105C02 permease PDUR_18700 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) PDUR_18705 ENOG4108B1Q Ribonuclease PDUR_18750 ENOG4107XGZ Hydrolase PDUR_18770 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) PDUR_18785 ENOG4105CQB FAD linked oxidase domain protein PDUR_18790 ENOG4108UMI ABC transporter, permease PDUR_18795 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PDUR_18800 ENOG4105D01 (LipO)protein PDUR_18805 ENOG4105CHM Aminotransferase PDUR_18815 ENOG4108W0I acetyltransferase PDUR_18820 ENOG4105CPC Aldo Keto reductase PDUR_18835 ENOG4107QI1 Mate efflux family protein PDUR_18840 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase PDUR_18850 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase PDUR_18855 ENOG4107YBY Hydrolase PDUR_18885 ENOG4105CQS hydrogenase expression formation protein HypD PDUR_18900 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) PDUR_18905 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) PDUR_18915 ENOG4107RSS Hydrogenase accessory protein HypB PDUR_18920 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) PDUR_18925 ENOG4108USZ hydrogenase PDUR_18930 ENOG4105DPX Hydrogenase, large subunit PDUR_18935 ENOG4105E3S small subunit PDUR_18940 ENOG4105E3S small subunit PDUR_18975 ENOG4108QG2 Membrane PDUR_18985 ENOG4108QY0 Membrane PDUR_19015 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) PDUR_19035 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein PDUR_19095 ENOG4105CNA YD repeat protein PDUR_19145 ENOG4107QJE Chromosome Partitioning Protein PDUR_19150 ENOG4105FA0 parb-like partition protein PDUR_19185 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) PDUR_19270 ENOG4106A3R peptidase PDUR_19410 ENOG4105DZR Type I site-specific deoxyribonuclease PDUR_19475 ENOG4105EKQ RNA-directed DNA polymerase PDUR_19600 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) PDUR_19605 ENOG4105N80 Ferric uptake regulator, Fur family PDUR_19610 ENOG4105DSE periplasmic solute binding protein PDUR_19620 ENOG4105DIK (ABC) transporter PDUR_19625 ENOG4105CKI cobalamin synthesis protein PDUR_19660 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) PDUR_19665 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) PDUR_19670 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain PDUR_19680 ENOG4105CD3 dihydroorotase PDUR_19685 ENOG4105CXT aspartate transcarbamylase PDUR_19695 ENOG4105CHM Aminotransferase PDUR_19700 ENOG4105C34 Pseudouridine synthase PDUR_19705 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) PDUR_19710 ENOG4105NHS Transcriptional regulator, TraR DksA family PDUR_19715 ENOG4105C7K acetolactate synthase PDUR_19740 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) PDUR_19750 ENOG4105DBK s4 domain protein PDUR_19755 ENOG41067XK integral membrane protein PDUR_19760 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) PDUR_19765 ENOG4105DFA alanine racemase domain protein PDUR_19770 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase PDUR_19775 ENOG4105WR5 sporulation protein, YlmC YmxH family PDUR_19785 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PDUR_19790 ENOG4105FFI sigma-e processing peptidase spoiiga PDUR_19795 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) PDUR_19800 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) PDUR_19805 ENOG41087KY Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) PDUR_19810 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) PDUR_19815 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) PDUR_19820 ENOG4105CNI cell division protein FtsW PDUR_19825 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) PDUR_19830 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) PDUR_19835 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) PDUR_19840 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) PDUR_19845 ENOG4105CJN penicillin-binding protein PDUR_19860 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) PDUR_19865 ENOG4108V6E Cell division protein mraZ PDUR_19875 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) PDUR_19880 ENOG41074B2 UPF0747 protein PDUR_19885 ENOG4108JQ7 (ABC) transporter PDUR_19895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PDUR_19900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PDUR_19945 ENOG4108IAB Phoh family PDUR_19960 ENOG4108KGH TRANSCRIPTIONal PDUR_19970 ENOG4105CI3 gtp-binding protein typa PDUR_19980 ENOG4108ZCF integral membrane protein PDUR_19985 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) PDUR_19995 ENOG4105E4C Lytic transglycosylase catalytic PDUR_20020 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PDUR_20025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PDUR_20035 ENOG4105EGD dinuclear metal center protein, YbgI family PDUR_20055 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) PDUR_20060 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 PDUR_20065 ENOG4105C38 Glycyl-tRNA synthetase beta subunit PDUR_20070 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit PDUR_20075 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) PDUR_20085 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) PDUR_20095 ENOG4107YR5 Diacylglycerol kinase PDUR_20100 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) PDUR_20105 ENOG4105CTJ Metal Dependent Phosphohydrolase PDUR_20110 ENOG4105C9A Phoh family PDUR_20120 ENOG41068P3 sporulation protein YqfC PDUR_20130 ENOG4105DI5 UPF0365 protein PDUR_20135 ENOG4105F7J membrane-bound serine protease PDUR_20140 ENOG4105KTH gatB Yqey PDUR_20145 ENOG4105VCC 30S ribosomal protein S21 PDUR_20150 ENOG4105K59 histidine triad (HIT) protein PDUR_20155 ENOG4105EYH Exonuclease PDUR_20165 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation PDUR_20170 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination PDUR_20190 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) PDUR_20195 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) PDUR_20200 ENOG4108Z4T Peptidase M50 PDUR_20205 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) PDUR_20210 ENOG4105W4W Transcriptional regulator PDUR_20230 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) PDUR_20245 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP PDUR_20250 ENOG4108R3E Dna-3-methyladenine glycosylase i PDUR_20265 ENOG4105EMN RNA polymerase sigma factor PDUR_20285 ENOG4105C5Y PTS System PDUR_20305 ENOG4105CFG Acts as a chaperone (By similarity) PDUR_20315 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) PDUR_20320 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic PDUR_20325 ENOG4107QZM n-acetylglutamate synthase PDUR_20330 ENOG4105CSA Coproporphyrinogen iii oxidase PDUR_20335 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) PDUR_20355 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) PDUR_20360 ENOG4108IG5 Transcriptional regulator PDUR_20370 ENOG4105TQK DNA polymerase iii, delta' subunit PDUR_20380 ENOG4105EMN RNA polymerase sigma factor PDUR_20410 ENOG4105D7K pfkb domain protein PDUR_20425 ENOG4105JVQ RNA Polymerase PDUR_20445 ENOG4105CHR reductase PDUR_20450 ENOG4105CF7 AraC family transcriptional regulator PDUR_20465 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 PDUR_20470 ENOG4107YWA deoxycytidylate deaminase PDUR_20485 ENOG4105C8T Leucyl-tRNA synthetase PDUR_20495 ENOG4105C02 permease PDUR_20500 ENOG41060CR PDUR_20510 ENOG4105C3J Cysteine desulfurase PDUR_20525 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) PDUR_20530 ENOG4105D1H recombination factor protein RarA PDUR_20545 ENOG4105CIR epoxide hydrolase PDUR_20550 ENOG4105EEM helicase PDUR_20555 ENOG4105CUZ uba thif-type nad fad binding protein PDUR_20560 ENOG4105C9M aspartyl-trna synthetase PDUR_20565 ENOG4105CUT histidyl-tRNA synthetase PDUR_20585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) PDUR_20590 ENOG4105C2W permease PDUR_20595 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) PDUR_20600 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) PDUR_20615 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) PDUR_20625 ENOG4105CKP Polysaccharide Biosynthesis Protein PDUR_20630 ENOG4108QG2 Membrane PDUR_20655 ENOG4105VIE preprotein translocase, subunit YajC PDUR_20660 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) PDUR_20665 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) PDUR_20670 ENOG4105JFG SpoIID LytB domain protein PDUR_20675 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) PDUR_20680 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) PDUR_20685 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) PDUR_20740 ENOG4105CM2 brancheD-chain amino acid aminotransferase PDUR_20745 ENOG4105CQC Prephenate dehydratase PDUR_20750 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) PDUR_20755 ENOG4105D6E homoserine dehydrogenase PDUR_20760 ENOG41090I5 UPF0735 ACT domain-containing protein PDUR_20770 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control PDUR_20780 ENOG4105K46 50S ribosomal protein l27 PDUR_20785 ENOG4105X36 (ribosomal) protein PDUR_20790 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) PDUR_20795 ENOG4105C03 ribonuclease PDUR_20810 ENOG4107QMS site-determining protein PDUR_20815 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) PDUR_20825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) PDUR_20830 ENOG4105DFF Rod shape-determining protein mreb PDUR_20835 ENOG4105W5Q DNA repair protein (RadC PDUR_20855 ENOG4105CHR reductase PDUR_20860 ENOG4105BZU Histidine kinase PDUR_20865 ENOG4105DFU Cell wall formation (By similarity) PDUR_20870 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase PDUR_20875 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) PDUR_20895 ENOG41068KH stage VI sporulation protein D PDUR_20900 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) PDUR_20905 ENOG4108YBP pseudouridine synthase PDUR_20910 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase PDUR_20915 ENOG4105D52 delta-aminolevulinic acid dehydratase PDUR_20920 ENOG4105CPC Aldo Keto reductase PDUR_20940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PDUR_20955 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) PDUR_20965 ENOG4108IUQ atp-dependent protease PDUR_20970 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) PDUR_20975 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) PDUR_20980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) PDUR_20985 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation PDUR_21000 ENOG4105E2Z phosphate ABC transporter (Permease PDUR_21005 ENOG4105C8U phosphate abc transporter PDUR_21010 ENOG4105CVA phosphate PDUR_21020 ENOG4105CJ1 ABC, transporter PDUR_21025 ENOG41090VJ ABC-2 type transporter PDUR_21030 ENOG4107Z3H Transcriptional regulator, TetR family PDUR_21040 ENOG4105C75 arginyL-tRNA synthetase PDUR_21050 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) PDUR_21065 ENOG4105CAQ asparagine synthetase PDUR_21075 ENOG4105CV8 reductase PDUR_21095 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) PDUR_21100 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) PDUR_21120 ENOG4108D32 Methyltransferase PDUR_21125 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) PDUR_21130 ENOG41081QJ UBA THIF-type NAD FAD binding PDUR_21135 ENOG4108VQE nitrogen fixation protein PDUR_21145 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN PDUR_21150 ENOG4105D0B Nitrogenase protein alpha chain PDUR_21155 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain PDUR_21160 ENOG4105D0B Nitrogenase protein alpha chain PDUR_21175 ENOG4107TS3 membrane protein, TerC PDUR_21180 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs PDUR_21190 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PDUR_21220 ENOG4105CI1 PTS System PDUR_21250 ENOG4105EKQ RNA-directed DNA polymerase PDUR_21255 ENOG4105EKQ RNA-directed DNA polymerase PDUR_21260 ENOG4105F8D glycoside hydrolase family 4 PDUR_21265 ENOG4105CI1 PTS System PDUR_21270 ENOG4105PFC Transcriptional regulator PDUR_21275 ENOG4105G9B Transcriptional regulator PDUR_21280 ENOG4105CK2 sodium dicarboxylate symporter PDUR_21290 ENOG4105C30 Nad-dependent epimerase dehydratase PDUR_21315 ENOG4106KNT transcriptional regulator PDUR_21320 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) PDUR_21325 ENOG4105CE4 GlcNAc 6-P deacetylase PDUR_21335 ENOG4105K64 Glycosyl transferase, family 2 PDUR_21350 ENOG4105C5E polysaccharide biosynthesis protein PDUR_21355 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase PDUR_21360 ENOG4105CPK Glycosyl transferase (Group 1 PDUR_21435 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase PDUR_21440 ENOG4105C1B dTDP-glucose 4-6-dehydratase PDUR_21450 ENOG4105FAW cDP-glucose 4,6-dehydratase PDUR_21455 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase PDUR_21460 ENOG4107S6X Glycosyl transferase, family 2 PDUR_21470 ENOG4107XZA Glycosyl transferase family 2 PDUR_21480 ENOG4105E0M Sulfatase PDUR_21485 ENOG4105BZW Glycerate kinase PDUR_21515 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) PDUR_21520 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PDUR_21525 ENOG4108Z7F N-acetyltransferase PDUR_21560 ENOG4105C19 ABC transporter PDUR_21610 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) PDUR_21615 ENOG4105CKK Glycosyl transferase, family 2 PDUR_21625 ENOG4105CKK Glycosyl transferase, family 2 PDUR_21640 ENOG4105DJ4 phosphatidylserine decarboxylase PDUR_21645 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) PDUR_21650 ENOG4108R6W Transcriptional regulator, ARAC family PDUR_21795 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) PDUR_21815 ENOG4105D9P serine threonine protein kinase PDUR_21835 ENOG4105DHI Methyltransferase PDUR_21860 ENOG4105FDU atp-dependent rna helicase PDUR_21865 ENOG4108IXY short-chain dehydrogenase reductase PDUR_21875 ENOG4105GZI Transcriptional regulator PDUR_21890 ENOG4108Z0Z intracellular protease Pfpi family PDUR_21915 ENOG4105E33 succinate dehydrogenase PDUR_21925 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit PDUR_21930 ENOG4105DUM transcriptional regulator, lysR family PDUR_21935 ENOG4105C22 threonyL-tRNA synthetase PDUR_21945 ENOG4105CZN Potassium uptake protein PDUR_21955 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) PDUR_21965 ENOG4105K63 Thioredoxin PDUR_21990 ENOG4107JTW chlorite dismutase PDUR_22000 ENOG4105CEP NADH dehydrogenase PDUR_22040 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) PDUR_22055 ENOG4105EQD regulatoR PDUR_22060 ENOG4105C2F Histidine kinase PDUR_22220 ENOG41068WN PDUR_22245 ENOG41068WN PDUR_22260 ENOG4108YX9 iron--sulfur cluster insertion protein erpA PDUR_22270 ENOG4105DVY radical SAM domain protein PDUR_22280 ENOG4105ZKE UPF0349 protein PDUR_22285 ENOG41083MR nifu domain-containing protein PDUR_22295 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) PDUR_22315 ENOG4105SXS Protein of unknown function (DUF456) PDUR_22325 ENOG4107RF6 penicillin-binding protein PDUR_22330 ENOG4107RF6 penicillin-binding protein PDUR_22350 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) PDUR_22380 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) PDUR_22385 ENOG41067AE Membrane-bound metal-dependent hydrolase PDUR_22395 ENOG4105C31 Tryptophanyl-tRNA synthetase PDUR_22400 ENOG4108N2V aldose 1-epimerase PDUR_22435 ENOG4108Z18 K06886 hemoglobin PDUR_22445 ENOG4105H20 Sporulation integral membrane protein YlbJ PDUR_22450 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) PDUR_22460 ENOG4105CN1 protease PDUR_22470 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) PDUR_22490 ENOG4105C7S Dehydrogenase PDUR_22500 ENOG4107RUY (E1 component), alpha subunit PDUR_22520 ENOG4105CHR reductase PDUR_22535 ENOG4105C08 Histidine kinase PDUR_22545 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) PDUR_22550 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) PDUR_22625 ENOG4108IJ7 Glycine betaine PDUR_22630 ENOG4107HG4 Transcriptional regulator PDUR_22635 ENOG4108U05 Transcriptional regulator PDUR_22640 ENOG4107YB6 acetyltransferase, (GNAT) family PDUR_22655 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family PDUR_22675 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PDUR_22690 ENOG4105DCT glycerol dehydrogenase PDUR_22700 ENOG4105BZU Histidine kinase PDUR_22705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_22720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PDUR_22775 ENOG4105I1K ABC transporter PDUR_22810 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component PDUR_22825 ENOG4105D38 putrescine abc transporter PDUR_22835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PDUR_22845 ENOG4105CPQ Dehydrogenase PDUR_22850 ENOG4105CXK mandelate racemase muconate lactonizing PDUR_22855 ENOG4105DRR Transcriptional regulator, GntR family PDUR_22900 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs PDUR_22915 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PDUR_22920 ENOG4105E1F short-chain dehydrogenase reductase PDUR_22925 ENOG4108IG5 Transcriptional regulator PDUR_22930 ENOG4105C26 Dehydrogenase PDUR_22935 ENOG4105EMU Dehydrogenase PDUR_22940 ENOG4108RWN rrna methyltransferase PDUR_22945 ENOG4107ZYR domain protein PDUR_22955 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) PDUR_22960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase PDUR_22970 ENOG4105WH1 Two component transcriptional regulator luxr family PDUR_22975 ENOG4105ENE Histidine kinase PDUR_22985 ENOG41087YS Phage shock protein A PDUR_23010 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB PDUR_23030 ENOG4107HP6 Transcriptional regulator PDUR_23050 ENOG4108YYH Nadph-dependent fmn reductase PDUR_23150 ENOG4105TUA UPF0295 protein PDUR_23160 ENOG4105G5W regulator Fur family PDUR_23170 ENOG4105RHY Pfam:UPF0157 PDUR_23175 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) PDUR_23180 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) PDUR_23185 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) PDUR_23200 ENOG4105DA5 (ABC) transporter PDUR_23230 ENOG4105C5X domain protein PDUR_23240 ENOG4107T5V SNARE associated Golgi PDUR_23245 ENOG41082BM Transcriptional regulator, arsr family PDUR_23275 ENOG4107TIF Phenazine biosynthesis protein, PhzF family PDUR_23290 ENOG4108ZDA Sporulation protein YyaC PDUR_23295 ENOG41068PA UPF0435 protein PDUR_23320 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) PDUR_23335 ENOG4105BZU Histidine kinase PDUR_23340 ENOG4108MJI response regulator PDUR_23355 ENOG4105K4H Nlp p60 protein PDUR_23375 ENOG4105C5H ABC transporter PDUR_23400 ENOG4105C3M thioredoxin reductase PDUR_23405 ENOG4105C59 p-type ATPase PDUR_23425 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) PDUR_23430 ENOG4105EPW hflc protein PDUR_23440 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase PDUR_23455 ENOG4108KHX Diguanylate cyclase PDUR_23460 ENOG4105WH1 Two component transcriptional regulator luxr family PDUR_23495 ENOG4105ERH Fumarylacetoacetate hydrolase PDUR_23500 ENOG4108X4Q Hydrolase PDUR_23510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase PDUR_23530 ENOG4105E1K spore germination protein PDUR_23695 ENOG4105CPC Aldo Keto reductase PDUR_23700 ENOG4105VUF Transcriptional regulator PDUR_23715 ENOG4105M4P Tetr family transcriptional regulator PDUR_23720 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein PDUR_23740 ENOG4108UXE Protein tyrosine phosphatase PDUR_23745 ENOG4107R5R arsenical pump membrane protein PDUR_23750 ENOG41082YX Transcriptional regulator, arsr family PDUR_23755 ENOG41082YX Transcriptional regulator, arsr family PDUR_23760 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PDUR_23770 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PDUR_23775 ENOG4105CHR reductase PDUR_23795 ENOG4105E5Q amino acid AbC transporter PDUR_23800 ENOG4106PMH Extracellular solute-binding protein family 3 PDUR_23855 ENOG4105CZN Potassium uptake protein PDUR_23860 ENOG4105KJM monovalent cation h antiporter subunit g PDUR_23865 ENOG4105W4C monovalent cation H antiporter subunit F PDUR_23870 ENOG4105SC1 monovalent cation H antiporter subunit E PDUR_23875 ENOG4108JPZ Monovalent cation H antiporter subunit D PDUR_23880 ENOG4108ZE9 Monovalent cation H antiporter subunit C PDUR_23885 ENOG4105D65 subunit l PDUR_23920 ENOG4105CNG UPF0061 protein PDUR_23925 ENOG41068KG domain protein PDUR_23960 ENOG4105CHM Aminotransferase PDUR_23970 ENOG4105FTQ Dna gyrase PDUR_24000 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) PDUR_24010 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) PDUR_24020 ENOG4105C8B TIGR00159 family PDUR_24030 ENOG4105EMN RNA polymerase sigma factor PDUR_24035 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) PDUR_24080 ENOG41066EA baseplate J family protein PDUR_24125 ENOG4105FR7 XkdM protein, phage-like element PBSX PDUR_24130 ENOG4105PQS phage protein PDUR_24255 ENOG4108NMV polysaccharide deacetylase PDUR_24260 ENOG4105CSR polyphosphate kinase 2 PDUR_24275 ENOG4105D1F ATP-binding protein PDUR_24285 ENOG4107RIQ Sulfate adenylate transferase PDUR_24290 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) PDUR_24295 ENOG4108UJD 30S ribosomal protein S9 PDUR_24300 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) PDUR_24305 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) PDUR_24310 ENOG4108ZT0 50S ribosomal protein l17 PDUR_24315 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PDUR_24320 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) PDUR_24325 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits PDUR_24330 ENOG41067V7 50S ribosomal protein L36 PDUR_24335 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) PDUR_24345 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) PDUR_24350 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) PDUR_24355 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) PDUR_24360 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) PDUR_24365 ENOG4105VPB 50S ribosomal protein L30 PDUR_24370 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) PDUR_24375 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) PDUR_24380 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) PDUR_24385 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) PDUR_24390 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits PDUR_24395 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) PDUR_24400 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) PDUR_24405 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal PDUR_24410 ENOG41082SA 50s ribosomal protein l29 PDUR_24415 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) PDUR_24420 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) PDUR_24425 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) PDUR_24430 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) PDUR_24435 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity PDUR_24440 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) PDUR_24445 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) PDUR_24450 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) PDUR_24455 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) PDUR_24460 ENOG4106YBV Methyl-accepting chemotaxis PDUR_24465 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) PDUR_24470 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) PDUR_24475 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) PDUR_24480 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) PDUR_24485 ENOG4105XPM ribosomal protein PDUR_24490 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PDUR_24495 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PDUR_24500 ENOG4107Y49 methyltransferase PDUR_24505 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) PDUR_24510 ENOG4108VZM 50s ribosomal protein L10 PDUR_24515 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) PDUR_24520 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) PDUR_24525 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) PDUR_24530 ENOG410683Z Preprotein translocase SecE subunit PDUR_24535 ENOG4105QIV RNA polymerase PDUR_24540 ENOG4105M0M Tetracycline resistance protein PDUR_24545 ENOG4105C2N RNA methyltransferase TrmH family group 3 PDUR_24550 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) PDUR_24560 ENOG4105D7W serine acetyltransferase PDUR_24565 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) PDUR_24570 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) PDUR_24575 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) PDUR_24580 ENOG4105CTP PilT protein domain protein PDUR_24590 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase PDUR_24595 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) PDUR_24600 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) PDUR_24610 ENOG41066A3 ATP guanido phosphotransferase PDUR_24615 ENOG4108Z0C Uvrb UvrC protein PDUR_24630 ENOG4105CG3 alpha amylase, catalytic region PDUR_24635 ENOG4107FKK extracellular solute-binding protein family 1 PDUR_24645 ENOG4105EG2 ABC transporter, permease PDUR_24650 ENOG4105ETE Transcriptional regulator (LacI family PDUR_24685 ENOG4105EU0 Major facilitator Superfamily PDUR_24690 ENOG4105BZ4 penicillin-binding protein PDUR_24710 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) PDUR_24725 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) PDUR_24730 ENOG4105G6Z alkaline phosphatase PDUR_24740 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) PDUR_24745 ENOG4105C4R Atp-dependent dna helicase PDUR_24750 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) PDUR_24755 ENOG4105D3Q Sugar transferase PDUR_24775 ENOG4107QIV Cytochrome c biogenesis protein PDUR_24790 ENOG4105EHG Permease protein PDUR_24800 ENOG4105DVE abc transporter atp-binding protein PDUR_24835 ENOG4105CKK Glycosyl transferase, family 2 PDUR_24840 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase PDUR_24870 ENOG4105K64 Glycosyl transferase, family 2 PDUR_24875 ENOG4105CJT Mannose-1-phosphate guanylyltransferase PDUR_24880 ENOG4107VDP teichoic acid biosynthesis PDUR_24895 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) PDUR_24900 ENOG4105EY8 ABC transporter PDUR_24920 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase PDUR_24930 ENOG4105CFP Peptidase U32 PDUR_24940 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase PDUR_24960 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) PDUR_24965 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PDUR_24970 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) PDUR_24980 ENOG4105ER2 Ompa motb domain protein PDUR_25010 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) PDUR_25015 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor PDUR_25020 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor PDUR_25035 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) PDUR_25060 ENOG4108KYE ABC-2 type transporter PDUR_25065 ENOG4105CJ1 ABC, transporter PDUR_25075 ENOG4105WH1 Two component transcriptional regulator luxr family PDUR_25090 ENOG4105CN1 protease PDUR_25095 ENOG4105DR5 peptidase PDUR_25100 ENOG4105CRP Part of the ABC transporter FtsEX involved in PDUR_25105 ENOG4105CAK Cell division ATP-binding protein ftsE PDUR_25110 ENOG41073R8 VanW family PDUR_25120 ENOG4107UWA esterase PDUR_25125 ENOG4105CH7 arginosuccinase PDUR_25130 ENOG4105CDH Citrulline--aspartate ligase PDUR_25135 ENOG4105DBV ornithine carbamoyltransferase PDUR_25145 ENOG4105CAS nag kinase PDUR_25150 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) PDUR_25155 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase PDUR_25165 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) PDUR_25170 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving PDUR_25175 ENOG4105MS2 ribosomal subunit Interface protein PDUR_25185 ENOG4105VEQ Cold shock protein PDUR_25190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase PDUR_25195 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase PDUR_25200 ENOG4105D2T synthase PDUR_25225 ENOG4105I03 Flagellin PDUR_25235 ENOG4105MQ3 flagellar protein FliS PDUR_25240 ENOG4107V1F Flagellar hook-associated 2 domain-containing protein PDUR_25250 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) PDUR_25255 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) PDUR_25265 ENOG4105DTJ flagellar hook-associated protein PDUR_25270 ENOG4105E1Q flagellar hook-associated protein PDUR_25285 ENOG4105RU3 PDUR_25320 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP PDUR_25350 ENOG4105ESV Glycosyl transferase, family 4 PDUR_25385 ENOG4105CGA flagellar basal-body rod protein FlgG PDUR_25400 ENOG4105MT0 Sporulation transcriptional regulator spoiiid PDUR_25405 ENOG4105FRN stage II sporulation protein PDUR_25415 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) PDUR_25420 ENOG4106778 Protein of unknown function (DUF1146) PDUR_25425 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) PDUR_25430 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) PDUR_25435 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) PDUR_25440 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) PDUR_25450 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) PDUR_25455 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) PDUR_25460 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) PDUR_25475 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase PDUR_25485 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) PDUR_25490 ENOG4108UIC UPF0340 protein PDUR_25495 ENOG4107WAU Protein tyrosine phosphatase PDUR_25500 ENOG410815N Probably functions as a manganese efflux pump (By similarity) PDUR_25505 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) PDUR_25510 ENOG4108ZXQ stage ii sporulation protein r PDUR_25520 ENOG4105CNI cell division protein FtsW PDUR_25525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) PDUR_25530 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) PDUR_25535 ENOG4105C3G gtp-binding protein PDUR_25550 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) PDUR_25555 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) PDUR_25575 ENOG4108ZUB Lysine exporter protein (Lyse ygga) PDUR_25580 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PDUR_25585 ENOG4105BZU Histidine kinase PDUR_25595 ENOG4105BZ1 (ABC) transporter PDUR_25600 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) PDUR_25605 ENOG4105D8G Major Facilitator superfamily PDUR_25610 ENOG4105CX6 glutaminyL-tRNA synthetase PDUR_25625 ENOG4108RPX mosc domain containing protein PDUR_25635 ENOG4108J2R molybdopterin oxidoreductase PDUR_25640 ENOG4105TMB Formate nitrite transporter PDUR_25645 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase PDUR_25650 ENOG4105CKU formyltetrahydrofolate synthetase PDUR_25655 ENOG4105DEN Luciferase family PDUR_25665 ENOG4108VXD carboxy-peptidase PDUR_25690 ENOG4105EXQ uroporphyrinogen iii synthase hem4 PDUR_25700 ENOG41090R7 Ferric uptake PDUR_25705 ENOG4105BZU Histidine kinase PDUR_25745 ENOG4105CMU LysR family (Transcriptional regulator PDUR_25755 ENOG41067MG lrgb family PDUR_25770 ENOG4105E0M Sulfatase PDUR_25825 ENOG4105E5H Transposase PDUR_25970 ENOG4105C8Q Methyl-accepting chemotaxis PDUR_25975 ENOG4108PCN EamA-like transporter family PDUR_26005 ENOG4105BZU Histidine kinase PDUR_26025 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase PDUR_26045 ENOG4105CPC Aldo Keto reductase PDUR_26060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component PDUR_26065 ENOG4108UHU Aldolase PDUR_26070 ENOG4108JQ1 Dehydrogenase PDUR_26085 ENOG4105D7K pfkb domain protein PDUR_26095 ENOG4108M60 Transcriptional regulator PDUR_26125 ENOG4108HKT sucrose-6-phosphate hydrolase PDUR_26150 ENOG4108JJA ABC, transporter PDUR_26170 ENOG4108TU7 Inherit from COG: (ABC) transporter PDUR_26175 ENOG4105CJ1 ABC, transporter PDUR_26210 ENOG4105D01 (LipO)protein PDUR_26215 ENOG4108UMI ABC transporter, permease PDUR_26235 ENOG4107SJI Dehydrogenase PDUR_26240 ENOG4105BZ8 glutamate synthase PDUR_26245 ENOG4105G9B Transcriptional regulator PDUR_26250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) PDUR_26255 ENOG4105C26 Dehydrogenase PDUR_26260 ENOG4107XKF NMT1 THI5 Like Domain Protein PDUR_26265 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component PDUR_26280 ENOG4105I3N Conserved Protein PDUR_26345 ENOG4105C2C drug resistance transporter, Bcr CflA PDUR_26360 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr PDUR_26370 ENOG4105FBA Phospholipase Carboxylesterase PDUR_26375 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase PDUR_26380 ENOG4108VGI doxx family PDUR_26385 ENOG41090MY MarR family Transcriptional regulator PDUR_26390 ENOG4108UIH futalosine nucleosidase PDUR_26395 ENOG4105E63 Pfam:DUF178 PDUR_26415 ENOG4105RHY Pfam:UPF0157 PDUR_26435 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) PDUR_26500 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PDUR_26505 ENOG4107QVI Methyltransferase, type 11 PDUR_26510 ENOG4107RUE extracellular solute-binding protein family 1 PDUR_26530 ENOG4107XWI flavin reductase domain protein, FMN-binding PDUR_26535 ENOG4107RT3 EamA-like transporter family PDUR_26540 ENOG4105CPC Aldo Keto reductase PDUR_26550 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) PDUR_26560 ENOG4105DHT Metal Dependent Phosphohydrolase PDUR_26580 ENOG4107RK0 Sucrose phosphorylase PDUR_26585 ENOG4105ETE Transcriptional regulator (LacI family PDUR_26590 ENOG41068K0 YCII-related domain PDUR_26595 ENOG4105DEN Luciferase family PDUR_26600 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) PDUR_26605 ENOG4105KVH Transcriptional regulator PDUR_26630 ENOG41080HJ 6-phospho 3-hexuloisomerase PDUR_26635 ENOG4108VA3 3-hexulose-6-phosphate synthase PDUR_26640 ENOG4105UQX Mate efflux family protein PDUR_26655 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) PDUR_26665 ENOG4105NRA 50s ribosomal protein l31 type b PDUR_26715 ENOG4105KPY Small multidrug resistance protein PDUR_26785 ENOG4105EU9 PDUR_26810 ENOG4108IUW ABC transporter PDUR_26855 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) PDUR_26860 ENOG4105CHR reductase PDUR_26865 ENOG4105CXB phosphoribosylaminoimidazole synthetase PDUR_26890 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) PDUR_26900 ENOG4108X0B nad(p)h dehydrogenase (quinone) PDUR_26915 ENOG4105KVH Transcriptional regulator PDUR_26920 ENOG4105E09 nadh pyrophosphatase PDUR_26930 ENOG4105FKZ Methyl-accepting chemotaxis PDUR_26965 ENOG41082BM Transcriptional regulator, arsr family PDUR_26970 ENOG4108PVQ transcriptional regulator PDUR_26985 ENOG4107VQW regulatoR PDUR_26990 ENOG4105C2F Histidine kinase PDUR_27000 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PDUR_27005 ENOG4105C4Y ABC transporter PDUR_27015 ENOG4105NAE bifunctional deaminase-reductase domain protein PDUR_27025 ENOG4108IPJ Membrane PDUR_27030 ENOG4105C28 cystathionine PDUR_27035 ENOG4108IQI permease PDUR_27065 ENOG4107RB3 L-asparaginase PDUR_27080 ENOG4107V2S Transcriptional regulator PDUR_27095 ENOG4108QY0 Membrane PDUR_27110 ENOG4107QM2 Aldo Keto reductase PDUR_27125 ENOG4105E35 Dipicolinate synthase subunit A PDUR_27130 ENOG4105BZU Histidine kinase PDUR_27145 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PDUR_27160 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA PDUR_27170 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PDUR_27175 ENOG4108ETT Dehydrogenase PDUR_27230 ENOG4105BZU Histidine kinase PDUR_27255 ENOG4105CHM Aminotransferase PDUR_27270 ENOG4105BZU Histidine kinase PDUR_27275 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) PDUR_27320 ENOG4105CYX Short-chain dehydrogenase reductase Sdr PDUR_27325 ENOG4105DWT malate dehydrogenase (quinone) PDUR_27335 ENOG4108DMH HTH_ARAC PDUR_27350 ENOG41086D8 Transcriptional regulator PDUR_27375 ENOG4107XDY Nicotinamide Mononucleotide Transporter PDUR_27380 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein PDUR_27385 ENOG4105KVH Transcriptional regulator PDUR_27400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PDUR_27405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr PDUR_27415 ENOG4105EEM helicase PDUR_27430 ENOG4105KVH Transcriptional regulator PDUR_27435 ENOG4108X0B nad(p)h dehydrogenase (quinone) PDUR_27510 ENOG4105C85 amino acid PDUR_27515 ENOG4105BZU Histidine kinase PDUR_27540 ENOG4105R8C Transcriptional regulator PDUR_27550 ENOG4105ECI YeeC-like protein PDUR_27555 ENOG4105F6A helicase PDUR_27560 ENOG4105D85 methylase PDUR_27605 ENOG4108JJ8 (ABC) transporter PDUR_27610 ENOG4108JJ9 ABC, transporter PDUR_27615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii PDUR_27620 ENOG4105C4M (Ubiquinol oxidase) subunit I PDUR_27630 ENOG4105VEQ Cold shock protein PDUR_27635 ENOG4105C0H protease PDUR_27645 ENOG4105Q2H domain protein PDUR_27660 ENOG4105BZU Histidine kinase PDUR_27665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PDUR_27670 ENOG4105DR5 peptidase PDUR_27685 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis PDUR_27690 ENOG4105CDU Replicative dna helicase PDUR_27695 ENOG4105K9Q Binds to the 23S rRNA (By similarity) PDUR_27700 ENOG4105BZR domain protein PDUR_27720 ENOG4108KGH TRANSCRIPTIONal PDUR_27740 ENOG4105C98 muts2 protein PDUR_27745 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) PDUR_27750 ENOG4108UUM single-stranded DNA-binding protein PDUR_27755 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) PDUR_27785 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PDUR_27795 ENOG4105VDK protein, conserved in bacteria PDUR_27800 ENOG4105D8X mechanosensitive ion channel PDUR_27810 ENOG4108ZDA Sporulation protein YyaC PDUR_27825 ENOG4105FA0 parb-like partition protein PDUR_27830 ENOG4107QJE Chromosome Partitioning Protein PDUR_27840 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) PDUR_27845 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) PDUR_27850 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) PDUR_27855 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein PDUR_27860 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins PDUR_27865 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) PDUR_27870 ENOG4105VG0 50S ribosomal protein l34