locus-tag	class	description
F0161_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0161_00010	COG0592	DNA-directed DNA polymerase activity
F0161_00015	COG2501	S4 domain
F0161_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0161_00025	COG0187	DNA topoisomerase II activity
F0161_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
F0161_00040	COG0629	single-stranded DNA binding
F0161_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0161_00060	COG0330	HflC and HflK could
F0161_00065	COG1414	Transcriptional regulator
F0161_00085	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0161_00100	COG0359	binds to the 23S rRNA
F0161_00105	COG0305	Participates in initiation and elongation during chromosome replication
F0161_00120	COG0346	lactoylglutathione lyase activity
F0161_00130	COG0745	RESPONSE REGULATOR receiver
F0161_00135	COG5002	protein histidine kinase activity
F0161_00145	COG4853	Protein conserved in bacteria
F0161_00150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0161_00155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0161_00160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F0161_00175	COG1914	H( )-stimulated, divalent metal cation uptake system
F0161_00190	COG0431	NADPH-dependent FMN reductase
F0161_00190	COG1053	succinate dehydrogenase
F0161_00190	COG3976	FMN-binding domain protein
F0161_00195	COG0431	NADPH-dependent FMN reductase
F0161_00195	COG1053	succinate dehydrogenase
F0161_00195	COG3976	FMN-binding domain protein
F0161_00205	COG0738	Major facilitator superfamily
F0161_00230	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0161_00255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0161_00260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0161_00270	COG1132	(ABC) transporter
F0161_00275	COG1132	(ABC) transporter
F0161_00280	COG0640	Transcriptional regulator
F0161_00305	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_00315	COG1959	2 iron, 2 sulfur cluster binding
F0161_00365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0161_00405	COG1959	2 iron, 2 sulfur cluster binding
F0161_00430	COG1271	oxidase subunit
F0161_00435	COG1294	oxidase, subunit
F0161_00440	COG4988	ABC transporter
F0161_00445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0161_00450	COG0142	geranyltranstransferase activity
F0161_00470	COG1063	alcohol dehydrogenase
F0161_00480	COG0351	phosphomethylpyrimidine kinase
F0161_00485	COG1253	flavin adenine dinucleotide binding
F0161_00490	COG0110	maltose O-acetyltransferase activity
F0161_00495	COG0697	spore germination
F0161_00505	COG1733	regulation of RNA biosynthetic process
F0161_00510	COG2814	Major facilitator Superfamily
F0161_00515	COG0406	alpha-ribazole phosphatase activity
F0161_00530	COG1902	pentaerythritol trinitrate reductase activity
F0161_00545	COG3328	transposase activity
F0161_00575	COG0745	RESPONSE REGULATOR receiver
F0161_00585	COG0586	Pfam SNARE associated Golgi protein
F0161_00605	COG2130	NADP-dependent
F0161_00610	COG2801	Transposase and inactivated derivatives
F0161_00625	COG1846	Transcriptional regulator
F0161_00630	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
F0161_00640	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_00660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0161_00675	COG1070	Carbohydrate kinase
F0161_00680	COG3623	hexulose-6-phosphate isomerase
F0161_00720	COG3623	hexulose-6-phosphate isomerase
F0161_00735	COG0494	nUDIX hydrolase
F0161_00765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F0161_00790	COG1397	ADP-ribosylglycohydrolase
F0161_00795	COG1309	transcriptional regulator
F0161_00805	COG1309	transcriptional regulator
F0161_00820	COG0783	Belongs to the Dps family
F0161_00835	COG3142	Participates in the control of copper homeostasis
F0161_00845	COG1131	(ABC) transporter
F0161_00850	COG0531	amino acid
F0161_00875	COG2814	Major facilitator Superfamily
F0161_00885	COG1247	-acetyltransferase
F0161_00890	COG0456	acetyltransferase
F0161_00890	COG1846	Transcriptional regulator
F0161_00910	COG3275	phosphorelay sensor kinase activity
F0161_00915	COG3279	Response regulator of the LytR AlgR family
F0161_00925	COG1346	cytolysis
F0161_00930	COG0004	ammonium transporteR
F0161_00950	COG0765	amino acid transport
F0161_00975	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0161_00980	COG3189	MarR family transcriptional regulator
F0161_00985	COG2918	glutathione biosynthetic process
F0161_00985	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0161_00990	COG0542	response to heat
F0161_01020	COG2252	PERMEase
F0161_01025	COG2252	PERMEase
F0161_01035	COG4640	response to antibiotic
F0161_01055	COG0110	maltose O-acetyltransferase activity
F0161_01060	COG1959	2 iron, 2 sulfur cluster binding
F0161_01070	COG3590	peptidase
F0161_01080	COG0789	Transcriptional regulator
F0161_01125	COG2217	Heavy metal translocating P-type atpase
F0161_01155	COG3328	transposase activity
F0161_01180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0161_01185	COG2814	Major facilitator Superfamily
F0161_01195	COG2233	PERMEase
F0161_01210	COG3507	Belongs to the glycosyl hydrolase 43 family
F0161_01215	COG2211	Major facilitator Superfamily
F0161_01225	COG2814	Major facilitator Superfamily
F0161_01230	COG1053	succinate dehydrogenase
F0161_01240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0161_01250	COG0738	Major facilitator superfamily
F0161_01255	COG2390	Transcriptional regulator
F0161_01275	COG1518	maintenance of DNA repeat elements
F0161_01290	COG2801	Transposase and inactivated derivatives
F0161_01305	COG1846	Transcriptional regulator
F0161_01325	COG2801	Transposase and inactivated derivatives
F0161_01340	COG1125	glycine betaine transport
F0161_01360	COG2801	Transposase and inactivated derivatives
F0161_01435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F0161_01440	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F0161_01445	COG0402	S-adenosylhomocysteine deaminase activity
F0161_01455	COG1846	Transcriptional regulator
F0161_01460	COG0697	spore germination
F0161_01465	COG0393	Putative heavy-metal-binding
F0161_01475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0161_01485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F0161_01490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0161_01495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F0161_01500	COG0131	Imidazoleglycerol-phosphate dehydratase
F0161_01505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0161_01510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0161_01515	COG0107	imidazoleglycerol-phosphate synthase activity
F0161_01525	COG0140	phosphoribosyl-ATP diphosphatase activity
F0161_01530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0161_01540	COG1307	EDD domain protein, DegV family
F0161_01555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_01565	COG0765	amino acid transport
F0161_01570	COG1126	abc transporter atp-binding protein
F0161_01580	COG1881	PFAM PEBP family protein
F0161_01590	COG0512	Glutamine amidotransferase of anthranilate synthase
F0161_01590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0161_01600	COG0134	indole-3-glycerol-phosphate synthase activity
F0161_01605	COG0135	phosphoribosylanthranilate isomerase activity
F0161_01610	COG0133	tryptophan synthase activity
F0161_01615	COG0159	tryptophan synthase activity
F0161_01660	COG2365	Tyrosine phosphatase family
F0161_01675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0161_01680	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F0161_01685	COG1609	Transcriptional regulator
F0161_01705	COG1164	Oligoendopeptidase f
F0161_01715	COG0803	Belongs to the bacterial solute-binding protein 9 family
F0161_01725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F0161_01735	COG0702	epimerase
F0161_01755	COG2801	Transposase and inactivated derivatives
F0161_01775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0161_01800	COG2807	transmembrane transport
F0161_01815	COG2814	Major facilitator Superfamily
F0161_01820	COG1113	amino acid transport
F0161_01825	COG1113	amino acid transport
F0161_01890	COG1737	Transcriptional regulator
F0161_01895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F0161_01910	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F0161_01920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0161_01945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F0161_01955	COG1012	belongs to the aldehyde dehydrogenase family
F0161_01965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0161_01990	COG1454	alcohol dehydrogenase
F0161_01990	COG1012	belongs to the aldehyde dehydrogenase family
F0161_02025	COG0656	L-ascorbic acid biosynthetic process
F0161_02030	COG1609	Transcriptional regulator
F0161_02035	COG2160	L-arabinose isomerase activity
F0161_02040	COG0667	Aldo Keto reductase
F0161_02050	COG0765	amino acid transport
F0161_02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_02065	COG0488	(ABC) transporter
F0161_02075	COG1131	(ABC) transporter
F0161_02085	COG1309	transcriptional regulator
F0161_02090	COG0710	3-dehydroquinate dehydratase activity
F0161_02095	COG2211	Major facilitator Superfamily
F0161_02095	COG2190	(PTS) system
F0161_02105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0161_02110	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F0161_02115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F0161_02120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0161_02125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0161_02130	COG0287	Prephenate dehydrogenase
F0161_02135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0161_02150	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_02160	COG1418	mRNA catabolic process
F0161_02180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0161_02185	COG2188	Transcriptional regulator
F0161_02190	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F0161_02205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0161_02210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0161_02215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0161_02220	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0161_02225	COG0047	phosphoribosylformylglycinamidine synthase activity
F0161_02230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F0161_02240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0161_02245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0161_02250	COG0138	bifunctional purine biosynthesis protein purh
F0161_02255	COG0151	Belongs to the GarS family
F0161_02260	COG1725	Transcriptional regulator
F0161_02265	COG1131	(ABC) transporter
F0161_02285	COG4152	abc transporter atp-binding protein
F0161_02290	COG1668	transmembrane transport
F0161_02300	COG0477	Major facilitator Superfamily
F0161_02305	COG2814	Major facilitator Superfamily
F0161_02315	COG0095	Lipoate-protein ligase
F0161_02335	COG1396	sequence-specific DNA binding
F0161_02340	COG2267	carboxylic ester hydrolase activity
F0161_02350	COG0025	NhaP-type Na H and K H
F0161_02355	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0161_02355	COG2918	glutathione biosynthetic process
F0161_02365	COG2153	protein acetylation
F0161_02375	COG1846	Transcriptional regulator
F0161_02390	COG1122	ATPase activity
F0161_02400	COG1957	nucleoside hydrolase
F0161_02405	COG0492	ferredoxin-NADP+ reductase activity
F0161_02410	COG1368	sulfuric ester hydrolase activity
F0161_02425	COG0346	lactoylglutathione lyase activity
F0161_02440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0161_02450	COG1811	Na channel or pump
F0161_02465	COG0564	pseudouridine synthase activity
F0161_02470	COG0861	Integral membrane protein TerC family
F0161_02475	COG3118	belongs to the thioredoxin family
F0161_02485	COG2084	Dehydrogenase
F0161_02500	COG0157	Belongs to the NadC ModD family
F0161_02505	COG0477	Major facilitator Superfamily
F0161_02520	COG4716	Myosin-crossreactive antigen
F0161_02525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0161_02530	COG4120	Belongs to the binding-protein-dependent transport system permease family
F0161_02540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0161_02545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0161_02560	COG3715	PTS system
F0161_02565	COG3716	PTS system mannose fructose sorbose family IID component
F0161_02570	COG0493	'glutamate synthase
F0161_02575	COG0069	glutamate synthase activity
F0161_02575	COG0067	glutamate synthase
F0161_02575	COG0070	glutamate synthase
F0161_02585	COG0719	Fe-S assembly protein
F0161_02590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0161_02600	COG0719	Fe-S assembly protein
F0161_02605	COG2151	metal-sulfur cluster biosynthetic enzyme
F0161_02615	COG0242	peptide deformylase activity
F0161_02625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0161_02630	COG0473	3-isopropylmalate dehydrogenase activity
F0161_02635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0161_02640	COG0066	3-isopropylmalate dehydratase activity
F0161_02675	COG0460	homoserine dehydrogenase
F0161_02685	COG0129	dihydroxy-acid dehydratase activity
F0161_02690	COG2151	metal-sulfur cluster biosynthetic enzyme
F0161_02695	COG0385	Bile acid
F0161_02700	COG2814	Major facilitator Superfamily
F0161_02715	COG0488	(ABC) transporter
F0161_02725	COG0697	spore germination
F0161_02730	COG0546	phosphoglycolate phosphatase activity
F0161_02735	COG1511	domain protein
F0161_02745	COG2267	carboxylic ester hydrolase activity
F0161_02755	COG1268	BioY protein
F0161_02760	COG2936	dipeptidyl-peptidase activity
F0161_02765	COG3842	ATPase activity
F0161_02770	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0161_02775	COG1177	transmembrane transport
F0161_02780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0161_02795	COG1902	pentaerythritol trinitrate reductase activity
F0161_02805	COG0477	Major facilitator Superfamily
F0161_02810	COG0477	Major facilitator Superfamily
F0161_02820	COG0531	amino acid
F0161_02835	COG0735	belongs to the Fur family
F0161_02850	COG0436	Aminotransferase
F0161_02860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_02865	COG0765	amino acid transport
F0161_02870	COG0765	amino acid transport
F0161_02885	COG2017	converts alpha-aldose to the beta-anomer
F0161_02905	COG1335	isochorismatase
F0161_02915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0161_02925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0161_02930	COG0588	phosphoglycerate mutase activity
F0161_02935	COG0586	Pfam SNARE associated Golgi protein
F0161_02940	COG3973	AAA domain
F0161_02945	COG1368	sulfuric ester hydrolase activity
F0161_02950	COG1072	(Pantothenic acid kinase))
F0161_02955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0161_02955	COG0519	Catalyzes the synthesis of GMP from XMP
F0161_02970	COG1573	uracil-dna glycosylase
F0161_03035	COG1609	Transcriptional regulator
F0161_03045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0161_03050	COG1869	D-ribose catabolic process
F0161_03060	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0161_03065	COG1879	ABC-type sugar transport system periplasmic component
F0161_03070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_03075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_03080	COG0765	amino acid transport
F0161_03095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0161_03105	COG0683	leucine binding
F0161_03125	COG0410	ABC transporter
F0161_03130	COG0516	GMP reductase activity
F0161_03130	COG0517	IMP dehydrogenase activity
F0161_03140	COG0386	Belongs to the glutathione peroxidase family
F0161_03145	COG0564	pseudouridine synthase activity
F0161_03155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0161_03185	COG2814	Major facilitator Superfamily
F0161_03200	COG1230	cation diffusion facilitator family transporter
F0161_03210	COG1278	Cold shock
F0161_03245	COG1959	2 iron, 2 sulfur cluster binding
F0161_03250	COG0833	amino acid
F0161_03255	COG1428	Deoxynucleoside kinase
F0161_03290	COG0577	efflux transmembrane transporter activity
F0161_03290	COG1136	(ABC) transporter
F0161_03300	COG4585	Histidine kinase
F0161_03305	COG2197	response regulator
F0161_03310	COG0477	Major facilitator Superfamily
F0161_03325	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_03340	COG0800	Aldolase
F0161_03370	COG2261	transglycosylase associated protein
F0161_03375	COG2261	transglycosylase associated protein
F0161_03405	COG2261	transglycosylase associated protein
F0161_03445	COG1307	EDD domain protein, DegV family
F0161_03470	COG0372	Belongs to the citrate synthase family
F0161_03475	COG0538	isocitrate dehydrogenase activity
F0161_03490	COG2848	UPF0210 protein
F0161_03495	COG3830	Belongs to the UPF0237 family
F0161_03500	COG1511	domain protein
F0161_03505	COG4463	regulation of RNA biosynthetic process
F0161_03510	COG0542	response to heat
F0161_03520	COG0085	RNA polymerase activity
F0161_03525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0161_03535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0161_03540	COG0049	tRNA binding
F0161_03545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0161_03550	COG0051	transcription antitermination factor activity, RNA binding
F0161_03555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0161_03560	COG0088	Forms part of the polypeptide exit tunnel
F0161_03565	COG0089	rRNA binding
F0161_03570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F0161_03575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0161_03580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F0161_03585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0161_03590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0161_03595	COG0255	Belongs to the universal ribosomal protein uL29 family
F0161_03605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0161_03610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0161_03615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F0161_03620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0161_03625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F0161_03630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0161_03635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0161_03640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0161_03650	COG0200	Binds to the 23S rRNA
F0161_03665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0161_03670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0161_03675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0161_03680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0161_03685	COG0202	RNA polymerase activity
F0161_03690	COG0203	ribosomal protein L17
F0161_03695	COG1122	ATPase activity
F0161_03700	COG1122	ATPase activity
F0161_03710	COG0101	tRNA pseudouridine synthase activity
F0161_03715	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_03720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0161_03725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0161_03735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0161_03740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0161_03795	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0161_03800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0161_03805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0161_03825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0161_03830	COG4851	CamS sex pheromone cAM373 precursor
F0161_03835	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F0161_03840	COG0154	amidase activity
F0161_03845	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F0161_03850	COG1597	lipid kinase activity
F0161_03855	COG1501	Belongs to the glycosyl hydrolase 31 family
F0161_03865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0161_03880	COG0400	carboxylic ester hydrolase activity
F0161_03885	COG0346	lactoylglutathione lyase activity
F0161_03895	COG0493	'glutamate synthase
F0161_03900	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F0161_03900	COG0167	dihydroorotate dehydrogenase activity
F0161_03910	COG1070	Carbohydrate kinase
F0161_03925	COG3655	Transcriptional regulator
F0161_03935	COG0673	inositol 2-dehydrogenase activity
F0161_03940	COG0513	Belongs to the DEAD box helicase family
F0161_03960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F0161_03970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0161_03985	COG2246	polysaccharide biosynthetic process
F0161_03990	COG0716	FMN binding
F0161_04000	COG0024	Methionine aminopeptidase
F0161_04010	COG2755	lipolytic protein G-D-S-L family
F0161_04010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F0161_04015	COG2801	Transposase and inactivated derivatives
F0161_04030	COG1959	2 iron, 2 sulfur cluster binding
F0161_04030	COG1295	ribonuclease BN
F0161_04045	COG2137	regulation of response to DNA damage stimulus
F0161_04065	COG3328	transposase activity
F0161_04090	COG1388	LysM domain
F0161_04090	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0161_04095	COG0463	Glycosyl transferase, family 2
F0161_04110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F0161_04140	COG1215	transferase activity, transferring glycosyl groups
F0161_04150	COG0562	UDP-galactopyranose mutase
F0161_04155	COG2244	polysaccharide biosynthetic process
F0161_04165	COG1316	TRANSCRIPTIONal
F0161_04175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F0161_04180	COG0628	permease
F0161_04200	COG2801	Transposase and inactivated derivatives
F0161_04215	COG4990	cell redox homeostasis
F0161_04240	COG0542	response to heat
F0161_04260	COG0738	Major facilitator superfamily
F0161_04265	COG1869	D-ribose catabolic process
F0161_04280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0161_04285	COG0438	transferase activity, transferring glycosyl groups
F0161_04290	COG0438	transferase activity, transferring glycosyl groups
F0161_04300	COG0436	Aminotransferase
F0161_04390	COG1328	CTP reductase activity
F0161_04395	COG0602	queuosine metabolic process
F0161_04405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0161_04410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0161_04425	COG2801	Transposase and inactivated derivatives
F0161_04450	COG0573	inorganic phosphate transmembrane transporter activity
F0161_04455	COG0581	inorganic phosphate transmembrane transporter activity
F0161_04465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F0161_04470	COG0704	Plays a role in the regulation of phosphate uptake
F0161_04475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F0161_04480	COG1984	allophanate hydrolase subunit 2
F0161_04485	COG0511	ligase activity, forming carbon-carbon bonds
F0161_04490	COG0439	Biotin carboxylase
F0161_04495	COG4336	lyase activity
F0161_04500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0161_04505	COG1914	H( )-stimulated, divalent metal cation uptake system
F0161_04510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0161_04525	COG1482	cell wall glycoprotein biosynthetic process
F0161_04550	COG1113	amino acid transport
F0161_04555	COG0519	Catalyzes the synthesis of GMP from XMP
F0161_04560	COG2818	Glycosylase
F0161_04570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F0161_04575	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F0161_04580	COG0671	phosphoesterase, PA-phosphatase related
F0161_04585	COG0495	leucyl-tRNA aminoacylation
F0161_04600	COG2244	polysaccharide biosynthetic process
F0161_04605	COG1187	pseudouridine synthase activity
F0161_04610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0161_04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0161_04620	COG0589	response to stress
F0161_04625	COG1388	LysM domain
F0161_04625	COG1705	Flagellar rod assembly protein muramidase FlgJ
F0161_04630	COG1428	Deoxynucleoside kinase
F0161_04675	COG1846	Transcriptional regulator
F0161_04680	COG0028	Belongs to the TPP enzyme family
F0161_04685	COG3527	Alpha-acetolactate decarboxylase
F0161_04695	COG3328	transposase activity
F0161_04710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0161_04735	COG2801	Transposase and inactivated derivatives
F0161_04760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0161_04765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0161_04765	COG0302	gtp cyclohydrolase
F0161_04770	COG0302	gtp cyclohydrolase
F0161_04775	COG0285	dihydrofolate synthase activity
F0161_04785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0161_04795	COG0534	Mate efflux family protein
F0161_04840	COG0420	3'-5' exonuclease activity
F0161_04845	COG0419	ATPase involved in DNA repair
F0161_04850	COG0583	DNA-binding transcription factor activity
F0161_04855	COG2855	membrane
F0161_04860	COG0656	L-ascorbic acid biosynthetic process
F0161_04880	COG0745	RESPONSE REGULATOR receiver
F0161_04885	COG5002	protein histidine kinase activity
F0161_04895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0161_04900	COG1696	Membrane protein involved in D-alanine export
F0161_04905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0161_04910	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F0161_04945	COG0018	arginyl-trna synthetase
F0161_04950	COG1438	arginine binding
F0161_04955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0161_04960	COG3679	Belongs to the UPF0342 family
F0161_04965	COG0420	3'-5' exonuclease activity
F0161_04970	COG4717	serine-type aminopeptidase activity
F0161_04985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0161_04995	COG0537	adenosine 5'-monophosphoramidase activity
F0161_05000	COG1131	(ABC) transporter
F0161_05010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0161_05020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0161_05025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0161_05035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0161_05045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0161_05045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0161_05050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0161_05055	COG0237	dephospho-CoA kinase activity
F0161_05060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0161_05070	COG1484	DNA-dependent DNA replication
F0161_05075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F0161_05080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0161_05085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0161_05090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F0161_05095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F0161_05100	COG1534	Rna-binding protein
F0161_05105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0161_05110	COG1713	HD superfamily hydrolase involved in NAD metabolism
F0161_05115	COG0799	negative regulation of ribosome biogenesis
F0161_05120	COG2226	methyltransferase
F0161_05125	COG1323	Belongs to the UPF0348 family
F0161_05135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0161_05175	COG1064	alcohol dehydrogenase
F0161_05185	COG0745	RESPONSE REGULATOR receiver
F0161_05190	COG5002	protein histidine kinase activity
F0161_05195	COG0706	membrane insertase activity
F0161_05200	COG1254	Belongs to the acylphosphatase family
F0161_05205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0161_05215	COG1733	regulation of RNA biosynthetic process
F0161_05220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F0161_05225	COG0072	phenylalanine-tRNA ligase activity
F0161_05225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0161_05230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0161_05235	COG0572	uridine kinase
F0161_05240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0161_05245	COG4841	protein insertion into membrane
F0161_05260	COG0768	penicillin binding
F0161_05265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0161_05270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0161_05275	COG0705	Rhomboid family
F0161_05275	COG0457	Tetratricopeptide repeat
F0161_05285	COG1940	carbohydrate kinase activity
F0161_05290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0161_05300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0161_05305	COG0789	Transcriptional regulator
F0161_05365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F0161_05375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F0161_05380	COG0006	proline dipeptidase activity
F0161_05385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0161_05390	COG1302	Protein conserved in bacteria
F0161_05395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0161_05400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0161_05405	COG1570	exodeoxyribonuclease VII activity
F0161_05410	COG1722	exodeoxyribonuclease VII activity
F0161_05420	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F0161_05425	COG1438	arginine binding
F0161_05430	COG0497	DNA recombination
F0161_05450	COG1174	glycine betaine transport
F0161_05460	COG0194	GDP metabolic process
F0161_05465	COG1758	RNA polymerase activity
F0161_05470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0161_05475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0161_05480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0161_05485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0161_05485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0161_05495	COG0515	serine threonine protein kinase
F0161_05495	COG2815	serine threonine protein kinase
F0161_05500	COG1162	GTPase activity
F0161_05505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0161_05510	COG1564	THIamine pyrophosphokinase
F0161_05520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0161_05525	COG1302	Protein conserved in bacteria
F0161_05535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0161_05540	COG0416	fatty acid biosynthetic process
F0161_05545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0161_05550	COG0571	ribonuclease III activity
F0161_05555	COG1196	nuclear chromosome segregation
F0161_05560	COG0552	protein localization to endoplasmic reticulum
F0161_05565	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F0161_05570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0161_05575	COG0228	four-way junction DNA binding
F0161_05590	COG0335	large ribosomal subunit rRNA binding
F0161_05610	COG1942	4-Oxalocrotonate Tautomerase
F0161_05615	COG0019	diaminopimelate decarboxylase activity
F0161_05620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0161_05625	COG0561	phosphatase activity
F0161_05630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F0161_05630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0161_05650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0161_05655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0161_05655	COG1199	ATP-dependent helicase activity
F0161_05670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0161_05675	COG3331	DNA recombination
F0161_05680	COG4474	Belongs to the UPF0398 family
F0161_05685	COG3599	regulation of cell shape
F0161_05695	COG0116	Belongs to the methyltransferase superfamily
F0161_05710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0161_05715	COG0328	RNA-DNA hybrid ribonuclease activity
F0161_05725	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F0161_05730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0161_05735	COG0564	pseudouridine synthase activity
F0161_05750	COG1293	RNA-binding protein homologous to eukaryotic snRNP
F0161_05760	COG1307	EDD domain protein, DegV family
F0161_05765	COG4974	Belongs to the 'phage' integrase family
F0161_05775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0161_05790	COG2801	Transposase and inactivated derivatives
F0161_05800	COG4372	Transposase
F0161_05815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0161_05845	COG0730	response to heat
F0161_05850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0161_05855	COG1227	inorganic diphosphatase activity
F0161_05870	COG0187	DNA topoisomerase II activity
F0161_05875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F0161_05890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0161_05895	COG0758	DNA mediated transformation
F0161_05900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0161_05910	COG4479	Belongs to the UPF0346 family
F0161_05915	COG4698	Protein conserved in bacteria
F0161_05920	COG2755	lipolytic protein G-D-S-L family
F0161_05925	COG1307	EDD domain protein, DegV family
F0161_05930	COG1272	protein, Hemolysin III
F0161_05935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F0161_05940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0161_05945	COG0488	(ABC) transporter
F0161_05950	COG0617	tRNA 3'-terminal CCA addition
F0161_05955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0161_05965	COG0457	Tetratricopeptide repeat
F0161_05975	COG1160	GTP binding
F0161_05980	COG0539	negative regulation of cytoplasmic translation
F0161_05985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0161_05995	COG0514	ATP-dependent DNA helicase (RecQ)
F0161_06005	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
F0161_06010	COG1187	pseudouridine synthase activity
F0161_06015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F0161_06020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F0161_06035	COG2996	Protein conserved in bacteria
F0161_06055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0161_06060	COG0587	DNA-directed DNA polymerase activity
F0161_06070	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0161_06075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0161_06080	COG2384	SAM-dependent methyltransferase
F0161_06085	COG2814	Major facilitator Superfamily
F0161_06095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0161_06100	COG0358	DNA primase activity
F0161_06105	COG0751	glycine-tRNA ligase activity
F0161_06110	COG0752	glycyl-tRNA synthetase alpha subunit
F0161_06115	COG1381	Involved in DNA repair and RecF pathway recombination
F0161_06120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0161_06130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0161_06135	COG1702	phosphate starvation-inducible protein PhoH
F0161_06140	COG1610	YqeY-like protein
F0161_06145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F0161_06150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0161_06155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F0161_06165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0161_06170	COG0124	histidyl-tRNA synthetase
F0161_06175	COG4991	sh3 domain protein
F0161_06175	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0161_06175	COG3103	Sh3 type 3 domain protein
F0161_06180	COG3001	Fructosamine kinase
F0161_06190	COG1490	D-aminoacyl-tRNA deacylase activity
F0161_06195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0161_06205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0161_06210	COG2264	protein methyltransferase activity
F0161_06240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0161_06250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0161_06260	COG2801	Transposase and inactivated derivatives
F0161_06290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F0161_06305	COG2801	Transposase and inactivated derivatives
F0161_06310	COG3328	transposase activity
F0161_06330	COG2801	Transposase and inactivated derivatives
F0161_06350	COG1401	restriction endodeoxyribonuclease activity
F0161_06355	COG1132	(ABC) transporter
F0161_06385	COG1609	Transcriptional regulator
F0161_06410	COG1053	succinate dehydrogenase
F0161_06410	COG0431	NADPH-dependent FMN reductase
F0161_06410	COG3976	FMN-binding domain protein
F0161_06420	COG1606	tRNA processing
F0161_06425	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
F0161_06430	COG1691	(AIR) carboxylase
F0161_06435	COG3875	lactate racemase activity
F0161_06440	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F0161_06445	COG0583	DNA-binding transcription factor activity
F0161_06450	COG0471	metal ion transport
F0161_06460	COG0114	fumarate hydratase activity
F0161_06480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F0161_06485	COG0110	maltose O-acetyltransferase activity
F0161_06490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0161_06505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0161_06510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0161_06545	COG1929	Belongs to the glycerate kinase type-1 family
F0161_06605	COG2801	Transposase and inactivated derivatives
F0161_06640	COG1388	LysM domain
F0161_06640	COG3942	CHAP domain
F0161_06775	COG5484	DNA packaging
F0161_06775	COG3728	DNA packaging
F0161_06865	COG1396	sequence-specific DNA binding
F0161_06895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0161_06900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0161_06900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0161_06905	COG0307	riboflavin synthase, alpha
F0161_06910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0161_06910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0161_06920	COG0789	Transcriptional regulator
F0161_06940	COG0308	aminopeptidase N
F0161_06950	COG0484	heat shock protein binding
F0161_06955	COG0443	Heat shock 70 kDa protein
F0161_06960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0161_06965	COG1420	regulation of RNA biosynthetic process
F0161_06980	COG1309	transcriptional regulator
F0161_06995	COG0735	belongs to the Fur family
F0161_07000	COG0196	riboflavin kinase activity
F0161_07005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0161_07010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0161_07015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0161_07015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0161_07025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F0161_07030	COG0195	Participates in both transcription termination and antitermination
F0161_07035	COG0779	Required for maturation of 30S ribosomal subunits
F0161_07040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0161_07045	COG2176	DNA-directed DNA polymerase activity
F0161_07050	COG0442	prolyl-tRNA aminoacylation
F0161_07055	COG0750	zinc metalloprotease
F0161_07060	COG4589	Belongs to the CDS family
F0161_07065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0161_07075	COG0528	UMP kinase activity
F0161_07085	COG0052	Belongs to the universal ribosomal protein uS2 family
F0161_07090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0161_07095	COG2827	Endonuclease containing a URI domain
F0161_07100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F0161_07105	COG0204	Acyl-transferase
F0161_07125	COG3763	UPF0154 protein
F0161_07130	COG4224	UPF0291 protein
F0161_07135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0161_07140	COG3425	synthase
F0161_07155	COG2801	Transposase and inactivated derivatives
F0161_07180	COG3328	transposase activity
F0161_07235	COG1194	a g-specific adenine glycosylase
F0161_07250	COG1518	maintenance of DNA repeat elements
F0161_07255	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
F0161_07265	COG2801	Transposase and inactivated derivatives
F0161_07295	COG0583	DNA-binding transcription factor activity
F0161_07305	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_07320	COG3328	transposase activity
F0161_07330	COG1611	Belongs to the LOG family
F0161_07350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0161_07355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F0161_07355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0161_07360	COG0300	oxidoreductase activity
F0161_07365	COG1234	tRNA 3'-trailer cleavage
F0161_07375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0161_07380	COG0322	excinuclease ABC activity
F0161_07395	COG1126	abc transporter atp-binding protein
F0161_07405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F0161_07410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0161_07415	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0161_07420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0161_07440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F0161_07445	COG0268	Binds directly to 16S ribosomal RNA
F0161_07450	COG1466	dna polymerase III delta subunit
F0161_07455	COG2333	competence protein COMEC
F0161_07455	COG0658	competence protein
F0161_07460	COG2131	deaminase
F0161_07465	COG1555	photosystem II stabilization
F0161_07465	COG1596	polysaccharide export
F0161_07470	COG3480	Lon protease (S16) C-terminal proteolytic domain
F0161_07475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0161_07480	COG0742	ribosomal rna small subunit methyltransferase
F0161_07485	COG4471	UPF0298 protein
F0161_07490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F0161_07495	COG0772	Belongs to the SEDS family
F0161_07500	COG1217	gtp-binding protein TYPA
F0161_07505	COG0483	inositol monophosphate 1-phosphatase activity
F0161_07510	COG4476	Belongs to the UPF0223 family
F0161_07535	COG0242	peptide deformylase activity
F0161_07545	COG5503	Protein of unknown function (DUF1447)
F0161_07550	COG1597	lipid kinase activity
F0161_07580	COG1393	Belongs to the ArsC family
F0161_07585	COG0588	phosphoglycerate mutase activity
F0161_07595	COG4475	Protein of unknown function (DUF436)
F0161_07600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0161_07605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0161_07625	COG0482	sulfurtransferase activity
F0161_07640	COG1104	cysteine desulfurase activity
F0161_07645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0161_07655	COG0494	nUDIX hydrolase
F0161_07660	COG1278	Cold shock
F0161_07665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0161_07670	COG2801	Transposase and inactivated derivatives
F0161_07685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0161_07690	COG3599	regulation of cell shape
F0161_07710	COG1799	cell septum assembly
F0161_07715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0161_07730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0161_07735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F0161_07740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0161_07745	COG0768	penicillin binding
F0161_07755	COG0275	rRNA processing
F0161_07760	COG2001	Belongs to the MraZ family
F0161_07780	COG1674	ftsk spoiiie
F0161_07785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0161_07790	COG2226	methyltransferase
F0161_07795	COG0628	permease
F0161_07800	COG2706	6-phosphogluconolactonase activity
F0161_07810	COG2239	Acts as a magnesium transporter
F0161_07815	COG0564	pseudouridine synthase activity
F0161_07820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0161_07825	COG2357	RelA SpoT domain protein
F0161_07840	COG2873	o-acetylhomoserine
F0161_07845	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F0161_07850	COG2801	Transposase and inactivated derivatives
F0161_07875	COG3328	transposase activity
F0161_07885	COG4862	establishment of competence for transformation
F0161_07890	COG1393	Belongs to the ArsC family
F0161_08020	COG0586	Pfam SNARE associated Golgi protein
F0161_08030	COG0647	UMP catabolic process
F0161_08035	COG4470	Protein conserved in bacteria
F0161_08040	COG0737	Belongs to the 5'-nucleotidase family
F0161_08050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0161_08055	COG0827	DNA restriction-modification system
F0161_08080	COG4537	Required for transformation and DNA binding
F0161_08085	COG1459	type II secretion system
F0161_08090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0161_08095	COG0217	transcriptional regulatory protein
F0161_08100	COG1609	Transcriptional regulator
F0161_08120	COG0668	transmembrane transport
F0161_08125	COG1473	amidohydrolase
F0161_08130	COG2171	N-acyltransferase activity
F0161_08140	COG0622	Phosphoesterase
F0161_08145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0161_08150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0161_08155	COG1719	4-vinyl reductase, 4VR
F0161_08160	COG3118	belongs to the thioredoxin family
F0161_08165	COG1193	negative regulation of DNA recombination
F0161_08180	COG2814	Major facilitator Superfamily
F0161_08185	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0161_08190	COG3906	Belongs to the UPF0473 family
F0161_08195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0161_08200	COG4472	Bacterial protein of unknown function (DUF965)
F0161_08210	COG0513	Belongs to the DEAD box helicase family
F0161_08215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F0161_08220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0161_08230	COG1862	Preprotein translocase
F0161_08235	COG0343	queuine tRNA-ribosyltransferase activity
F0161_08240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0161_08245	COG2255	four-way junction helicase activity
F0161_08250	COG0632	four-way junction helicase activity
F0161_08255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0161_08260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0161_08270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0161_08275	COG1546	Belongs to the CinA family
F0161_08275	COG1058	Belongs to the CinA family
F0161_08280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0161_08285	COG1426	Protein conserved in bacteria
F0161_08290	COG0612	Peptidase, M16
F0161_08295	COG0612	Peptidase, M16
F0161_08300	COG0527	aspartate kinase activity
F0161_08305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0161_08310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_08315	COG1126	abc transporter atp-binding protein
F0161_08320	COG0765	amino acid transport
F0161_08335	COG1077	Cell shape determining protein MreB Mrl
F0161_08340	COG2003	Belongs to the UPF0758 family
F0161_08345	COG0285	dihydrofolate synthase activity
F0161_08350	COG0525	valine-tRNA ligase activity
F0161_08355	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F0161_08360	COG0301	tRNA thio-modification
F0161_08365	COG1104	cysteine desulfurase activity
F0161_08370	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
F0161_08375	COG1956	GAF domain-containing protein
F0161_08380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0161_08385	COG4493	Belongs to the UPF0637 family
F0161_08395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0161_08420	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0161_08430	COG1464	Belongs to the NlpA lipoprotein family
F0161_08435	COG2011	ABC-type metal ion transport system permease component
F0161_08440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0161_08450	COG0772	Belongs to the SEDS family
F0161_08460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F0161_08465	COG1077	Cell shape determining protein MreB Mrl
F0161_08470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0161_08480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0161_08485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0161_08490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F0161_08495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0161_08500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0161_08505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0161_08510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0161_08515	COG0356	it plays a direct role in the translocation of protons across the membrane
F0161_08520	COG2233	PERMEase
F0161_08535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0161_08540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0161_08545	COG0009	L-threonylcarbamoyladenylate synthase
F0161_08550	COG2890	protein-(glutamine-N5) methyltransferase activity
F0161_08560	COG1435	thymidine kinase activity
F0161_08570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0161_08575	COG3442	glutamine amidotransferase
F0161_08595	COG1132	(ABC) transporter
F0161_08605	COG1846	Transcriptional regulator
F0161_08610	COG2610	gluconate transmembrane transporter activity
F0161_08620	COG2801	Transposase and inactivated derivatives
F0161_08630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0161_08635	COG0477	Major facilitator Superfamily
F0161_08665	COG1335	isochorismatase
F0161_08670	COG5646	InterPro IPR014922
F0161_08680	COG1376	ErfK ybiS ycfS ynhG family protein
F0161_08690	COG0252	asparaginase activity
F0161_08695	COG0166	Belongs to the GPI family
F0161_08700	COG4975	Glucose uptake
F0161_08705	COG3850	Histidine kinase
F0161_08705	COG5002	protein histidine kinase activity
F0161_08710	COG0745	RESPONSE REGULATOR receiver
F0161_08715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0161_08725	COG1695	Transcriptional regulator
F0161_08730	COG2962	Rard protein
F0161_08740	COG2814	Major facilitator Superfamily
F0161_08755	COG2801	Transposase and inactivated derivatives
F0161_08780	COG0561	phosphatase activity
F0161_08790	COG3475	LICD family
F0161_08820	COG0363	glucosamine-6-phosphate deaminase activity
F0161_08830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0161_08835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0161_08860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F0161_08865	COG0574	Belongs to the PEP-utilizing enzyme family
F0161_08865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0161_08870	COG0517	IMP dehydrogenase activity
F0161_08875	COG2176	DNA-directed DNA polymerase activity
F0161_08885	COG0802	atpase or kinase
F0161_08890	COG0280	phosphate acetyltransferase
F0161_08895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0161_08905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F0161_08910	COG0557	exoribonuclease II activity
F0161_08925	COG0148	phosphopyruvate hydratase activity
F0161_08950	COG0149	triose-phosphate isomerase activity
F0161_08965	COG0126	phosphoglycerate kinase activity
F0161_08980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0161_08990	COG0740	serine-type endopeptidase activity
F0161_08995	COG1481	regulation of sporulation
F0161_09005	COG1660	Displays ATPase and GTPase activities
F0161_09010	COG0165	Argininosuccinate lyase
F0161_09015	COG0137	argininosuccinate synthase activity
F0161_09020	COG1854	S-ribosylhomocysteine lyase activity
F0161_09025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0161_09030	COG0556	nucleotide-excision repair
F0161_09040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0161_09045	COG0577	efflux transmembrane transporter activity
F0161_09045	COG1136	(ABC) transporter
F0161_09060	COG0492	ferredoxin-NADP+ reductase activity
F0161_09065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0161_09070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0161_09075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0161_09080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F0161_09100	COG0653	protein targeting
F0161_09110	COG1040	competence protein
F0161_09115	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F0161_09120	COG1739	Uncharacterized protein family UPF0029
F0161_09125	COG0531	amino acid
F0161_09130	COG0459	protein refolding
F0161_09135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0161_09140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F0161_09145	COG0488	(ABC) transporter
F0161_09150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0161_09160	COG1214	PFAM Peptidase M22, glycoprotease
F0161_09165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0161_09180	COG4467	Involved in initiation control of chromosome replication
F0161_09185	COG0470	DNA polymerase III
F0161_09190	COG3870	Protein conserved in bacteria
F0161_09195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0161_09205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0161_09210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0161_09215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F0161_09225	COG0590	tRNA wobble adenosine to inosine editing
F0161_09230	COG2813	Specifically methylates the guanine in position
F0161_09235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0161_09240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0161_09255	COG1442	glycosyl transferase family 8
F0161_09255	COG1216	Glycosyl transferase, family 2
F0161_09280	COG2801	Transposase and inactivated derivatives
F0161_09290	COG0222	ribosome binding
F0161_09295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0161_09300	COG0081	regulation of translation
F0161_09310	COG0250	Participates in transcription elongation, termination and antitermination
F0161_09320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0161_09330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0161_09335	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F0161_09340	COG0215	cysteine-tRNA ligase activity
F0161_09355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0161_09360	COG4956	integral membrane protein (PIN domain superfamily)
F0161_09365	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F0161_09370	COG0756	dUTP diphosphatase activity
F0161_09385	COG0588	phosphoglycerate mutase activity
F0161_09400	COG0697	spore germination
F0161_09410	COG0825	malonyl-CoA metabolic process
F0161_09420	COG0439	Biotin carboxylase
F0161_09430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0161_09440	COG3091	SprT-like family
F0161_09445	COG2183	response to ionizing radiation
F0161_09455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0161_09460	COG1136	(ABC) transporter
F0161_09465	COG0577	efflux transmembrane transporter activity
F0161_09470	COG2188	Transcriptional regulator
F0161_09480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0161_09510	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0161_09515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0161_09520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F0161_09530	COG1132	(ABC) transporter
F0161_09540	COG1129	ABC transporter
F0161_09560	COG2826	transposase and inactivated derivatives, IS30 family
F0161_09580	COG3104	oligopeptide transport
F0161_09640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0161_09645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0161_09650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F0161_09660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F0161_09665	COG0037	tRNA processing
F0161_09670	COG1098	S1 RNA binding domain
F0161_09680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0161_09685	COG2244	polysaccharide biosynthetic process
F0161_09690	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0161_09695	COG0193	aminoacyl-tRNA hydrolase activity
F0161_09700	COG0039	L-malate dehydrogenase activity
F0161_09710	COG2337	Toxic component of a toxin-antitoxin (TA) module
F0161_09720	COG0736	holo-[acyl-carrier-protein] synthase activity
F0161_09730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0161_09735	COG0501	Belongs to the peptidase M48B family
F0161_09740	COG1704	LemA family
F0161_09745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F0161_09750	COG3764	Sortase (surface protein transpeptidase)
F0161_09760	COG0254	rRNA binding
F0161_09765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0161_09770	COG0504	CTP synthase activity
F0161_09775	COG3343	RNA polymerase activity
F0161_09785	COG0095	Lipoate-protein ligase
F0161_09790	COG1078	dGTPase activity
F0161_09800	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0161_09810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0161_09815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0161_09820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0161_09825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0161_09830	COG1121	(ABC) transporter
F0161_09835	COG1045	serine acetyltransferase
F0161_09840	COG0626	cystathionine gamma-synthase activity
F0161_09845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0161_09850	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F0161_09855	COG4466	Protein conserved in bacteria
F0161_09860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F0161_09865	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F0161_09870	COG0084	hydrolase, TatD family'
F0161_09875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0161_09875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0161_09890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0161_09905	COG0248	Ppx GppA phosphatase
F0161_09910	COG0180	Tryptophanyl-tRNA synthetase
F0161_09915	COG3973	AAA domain
F0161_09935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0161_09950	COG2910	NAD(P)H-binding
F0161_09965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F0161_09970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0161_09975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0161_09980	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F0161_09985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0161_09990	COG0505	Belongs to the CarA family
F0161_09995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0161_10000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F0161_10005	COG2390	Transcriptional regulator
F0161_10010	COG0813	purine-nucleoside phosphorylase activity
F0161_10015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0161_10020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0161_10025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0161_10045	COG0588	phosphoglycerate mutase activity
F0161_10050	COG0628	permease
F0161_10055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0161_10090	COG2801	Transposase and inactivated derivatives
F0161_10100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0161_10125	COG1686	Belongs to the peptidase S11 family
F0161_10130	COG5002	protein histidine kinase activity
F0161_10135	COG0745	RESPONSE REGULATOR receiver
F0161_10150	COG1091	dTDP-4-dehydrorhamnose reductase activity
F0161_10155	COG1088	dTDP-glucose 4,6-dehydratase activity
F0161_10175	COG2801	Transposase and inactivated derivatives
F0161_10180	COG0516	GMP reductase activity
F0161_10180	COG0517	IMP dehydrogenase activity
F0161_10190	COG0012	GTP binding
F0161_10195	COG4481	Protein conserved in bacteria
F0161_10200	COG1475	DNA binding
F0161_10205	COG1192	Involved in chromosome partitioning
F0161_10215	COG0357	Ribosomal RNA small subunit methyltransferase G
F0161_10225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0161_10230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0161_10235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0161_10240	COG1113	amino acid transport
F0161_10245	COG4221	oxidoreductase activity
F0161_10250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0161_10265	COG1764	response to oxidative stress
F0161_10270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0161_10285	COG3177	Filamentation induced by cAMP protein fic
F0161_10290	COG0352	thiamine-phosphate diphosphorylase activity
F0161_10295	COG0351	phosphomethylpyrimidine kinase
F0161_10300	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F0161_10310	COG0390	transport system, permease component
F0161_10315	COG4619	ABC transporter
F0161_10335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F0161_10345	COG0656	L-ascorbic acid biosynthetic process
F0161_10355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F0161_10365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0161_10380	COG0438	transferase activity, transferring glycosyl groups
F0161_10395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0161_10405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0161_10415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F0161_10420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0161_10425	COG0284	orotidine-5'-phosphate decarboxylase activity
F0161_10430	COG0167	dihydroorotate dehydrogenase activity
F0161_10440	COG0505	Belongs to the CarA family
F0161_10455	COG2801	Transposase and inactivated derivatives
F0161_10460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F0161_10465	COG0540	Belongs to the ATCase OTCase family
F0161_10470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F0161_10510	COG3048	D-serine ammonia-lyase activity
F0161_10520	COG0436	Aminotransferase
F0161_10525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0161_10530	COG2011	ABC-type metal ion transport system permease component
F0161_10535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0161_10550	COG0371	Dehydrogenase
F0161_10575	COG4886	Leucine-rich repeat (LRR) protein
F0161_10575	COG4932	domain protein
F0161_10580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0161_10585	COG1126	abc transporter atp-binding protein
F0161_10590	COG0765	amino acid transport
F0161_10595	COG0765	amino acid transport
F0161_10600	COG2873	o-acetylhomoserine
F0161_10605	COG0626	cystathionine gamma-synthase activity
F0161_10610	COG1126	abc transporter atp-binding protein
F0161_10625	COG2801	Transposase and inactivated derivatives
F0161_10640	COG1464	Belongs to the NlpA lipoprotein family
F0161_10645	COG2011	ABC-type metal ion transport system permease component
F0161_10650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0161_10655	COG1956	GAF domain-containing protein
F0161_10660	COG0531	amino acid
F0161_10675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0161_10680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0161_10685	COG0516	GMP reductase activity
F0161_10695	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F0161_10710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0161_10730	COG0346	lactoylglutathione lyase activity
F0161_10735	COG2508	Transcriptional regulator
F0161_10765	COG1376	ErfK ybiS ycfS ynhG family protein
F0161_10770	COG0438	transferase activity, transferring glycosyl groups
F0161_10825	COG0577	efflux transmembrane transporter activity
F0161_10860	COG0071	Belongs to the small heat shock protein (HSP20) family
F0161_10880	COG2814	Major facilitator Superfamily
F0161_10960	COG2261	transglycosylase associated protein
F0161_10995	COG1794	racemase activity, acting on amino acids and derivatives
F0161_11010	COG0367	asparagine synthase
F0161_11015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0161_11020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0161_11040	COG0445	tRNA wobble uridine modification
F0161_11045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0161_11060	COG0706	membrane insertase activity
F0161_11065	COG0594	ribonuclease P activity
F0161_11070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0161_11080	COG0551	DNA topoisomerase type I activity
F0161_11080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0161_11095	COG2801	Transposase and inactivated derivatives
F0161_11110	COG1268	BioY protein
F0161_11115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0161_11125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F0161_11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0161_11135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0161_11140	COG1028	Short-chain dehydrogenase reductase Sdr
F0161_11145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0161_11155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0161_11160	COG0439	Biotin carboxylase
F0161_11165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0161_11170	COG0825	malonyl-CoA metabolic process
F0161_11175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0161_11235	COG2801	Transposase and inactivated derivatives
F0161_11245	COG2226	methyltransferase
F0161_11290	COG2211	Major facilitator Superfamily
F0161_11310	COG1607	acyl-coa hydrolase
F0161_11335	COG1192	Involved in chromosome partitioning