locus-tag	class	description
ID874_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ID874_00010	COG0592	DNA-directed DNA polymerase activity
ID874_00015	COG2501	S4 domain
ID874_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ID874_00025	COG0187	DNA topoisomerase II activity
ID874_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
ID874_00040	COG0629	single-stranded DNA binding
ID874_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ID874_00055	COG0359	binds to the 23S rRNA
ID874_00060	COG0305	Participates in initiation and elongation during chromosome replication
ID874_00065	COG2814	Major facilitator Superfamily
ID874_00085	COG0488	(ABC) transporter
ID874_00100	COG1136	(ABC) transporter
ID874_00105	COG1396	sequence-specific DNA binding
ID874_00120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_00135	COG0431	NADPH-dependent FMN reductase
ID874_00145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ID874_00180	COG0789	Transcriptional regulator
ID874_00185	COG2076	Multidrug Resistance protein
ID874_00195	COG1272	protein, Hemolysin III
ID874_00240	COG1373	ATPase (AAA superfamily
ID874_00290	COG0583	DNA-binding transcription factor activity
ID874_00295	COG0110	maltose O-acetyltransferase activity
ID874_00300	COG4221	oxidoreductase activity
ID874_00325	COG1131	(ABC) transporter
ID874_00330	COG2188	Transcriptional regulator
ID874_00365	COG0583	DNA-binding transcription factor activity
ID874_00370	COG0656	L-ascorbic acid biosynthetic process
ID874_00425	COG1215	transferase activity, transferring glycosyl groups
ID874_00430	COG2723	6-phospho-beta-galactosidase activity
ID874_00455	COG0667	Aldo Keto reductase
ID874_00460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ID874_00470	COG3546	catalase activity
ID874_00505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID874_00520	COG4932	domain protein
ID874_00530	COG3775	system Galactitol-specific IIC component
ID874_00545	COG1349	DNA-binding transcription factor activity
ID874_00560	COG3684	Belongs to the aldolase LacD family
ID874_00575	COG1737	Transcriptional regulator
ID874_00585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID874_00585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_00585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_00590	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ID874_00600	COG1028	Short-chain dehydrogenase reductase Sdr
ID874_00605	COG4876	unkown
ID874_00620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ID874_00630	COG1737	Transcriptional regulator
ID874_00635	COG1285	pathogenesis
ID874_00640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID874_00645	COG3715	PTS system
ID874_00650	COG3716	PTS system mannose fructose sorbose family IID component
ID874_00665	COG2188	Transcriptional regulator
ID874_00675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_00695	COG2723	6-phospho-beta-galactosidase activity
ID874_00700	COG0028	Belongs to the TPP enzyme family
ID874_00715	COG0656	L-ascorbic acid biosynthetic process
ID874_00725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID874_00735	COG3715	PTS system
ID874_00740	COG3716	PTS system mannose fructose sorbose family IID component
ID874_00745	COG2222	sugar isomerase
ID874_00760	COG2207	Transcriptional regulator
ID874_00770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ID874_00775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ID874_00780	COG0813	purine-nucleoside phosphorylase activity
ID874_00785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ID874_00795	COG2390	Transcriptional regulator
ID874_00800	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ID874_00810	COG3940	Belongs to the glycosyl hydrolase 43 family
ID874_00830	COG1442	glycosyl transferase family 8
ID874_00845	COG1929	Belongs to the glycerate kinase type-1 family
ID874_00850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID874_00855	COG0697	spore germination
ID874_00860	COG0438	transferase activity, transferring glycosyl groups
ID874_00865	COG0438	transferase activity, transferring glycosyl groups
ID874_00870	COG0778	Nitroreductase
ID874_00880	COG1733	regulation of RNA biosynthetic process
ID874_00885	COG0604	alcohol dehydrogenase
ID874_00890	COG0351	phosphomethylpyrimidine kinase
ID874_00905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_00935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ID874_00940	COG2814	Major facilitator Superfamily
ID874_00970	COG0402	S-adenosylhomocysteine deaminase activity
ID874_00975	COG1174	glycine betaine transport
ID874_00980	COG0517	IMP dehydrogenase activity
ID874_00980	COG1125	glycine betaine transport
ID874_00995	COG3973	AAA domain
ID874_01030	COG1801	Protein of unknown function DUF72
ID874_01035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID874_01035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID874_01040	COG0084	hydrolase, TatD family'
ID874_01050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ID874_01055	COG4466	Protein conserved in bacteria
ID874_01060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ID874_01070	COG0589	response to stress
ID874_01080	COG0477	Major facilitator Superfamily
ID874_01090	COG3842	ATPase activity
ID874_01095	COG4120	Belongs to the binding-protein-dependent transport system permease family
ID874_01105	COG2188	Transcriptional regulator
ID874_01110	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_01115	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID874_01120	COG2723	6-phospho-beta-galactosidase activity
ID874_01130	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID874_01150	COG1288	antiporter activity
ID874_01155	COG1573	uracil-dna glycosylase
ID874_01160	COG0803	Belongs to the bacterial solute-binding protein 9 family
ID874_01165	COG1121	(ABC) transporter
ID874_01170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID874_01175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID874_01180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ID874_01205	COG3345	alpha-galactosidase
ID874_01210	COG1609	Transcriptional regulator
ID874_01275	COG4869	propanediol catabolic process
ID874_01285	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ID874_01300	COG1012	belongs to the aldehyde dehydrogenase family
ID874_01310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ID874_01320	COG1902	pentaerythritol trinitrate reductase activity
ID874_01325	COG2365	Tyrosine phosphatase family
ID874_01330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ID874_01355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ID874_01360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ID874_01380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ID874_01385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID874_01395	COG3590	peptidase
ID874_01400	COG2502	aspartate--ammonia ligase
ID874_01405	COG2252	PERMEase
ID874_01415	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ID874_01430	COG1215	transferase activity, transferring glycosyl groups
ID874_01460	COG2855	membrane
ID874_01475	COG0561	phosphatase activity
ID874_01480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ID874_01485	COG0540	Belongs to the ATCase OTCase family
ID874_01490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ID874_01495	COG0505	Belongs to the CarA family
ID874_01500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID874_01510	COG1053	succinate dehydrogenase
ID874_01520	COG2814	Major facilitator Superfamily
ID874_01525	COG0346	lactoylglutathione lyase activity
ID874_01535	COG0363	glucosamine-6-phosphate deaminase activity
ID874_01540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ID874_01545	COG0280	phosphate acetyltransferase
ID874_01550	COG0735	belongs to the Fur family
ID874_01555	COG2814	Major facilitator Superfamily
ID874_01560	COG1295	ribonuclease BN
ID874_01570	COG2365	Tyrosine phosphatase family
ID874_01575	COG2365	Tyrosine phosphatase family
ID874_01580	COG1780	Probably involved in ribonucleotide reductase function
ID874_01585	COG0561	phosphatase activity
ID874_01590	COG1131	(ABC) transporter
ID874_01600	COG1253	flavin adenine dinucleotide binding
ID874_01605	COG4989	oxidoreductase activity
ID874_01620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ID874_01625	COG2188	Transcriptional regulator
ID874_01630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ID874_01635	COG1051	belongs to the nudix hydrolase family
ID874_01640	COG0564	pseudouridine synthase activity
ID874_01650	COG1940	carbohydrate kinase activity
ID874_01660	COG0583	DNA-binding transcription factor activity
ID874_01675	COG1376	ErfK ybiS ycfS ynhG family protein
ID874_01685	COG0586	Pfam SNARE associated Golgi protein
ID874_01705	COG0025	NhaP-type Na H and K H
ID874_01715	COG0492	ferredoxin-NADP+ reductase activity
ID874_01720	COG1368	sulfuric ester hydrolase activity
ID874_01745	COG0861	Integral membrane protein TerC family
ID874_01750	COG3118	belongs to the thioredoxin family
ID874_01770	COG0488	(ABC) transporter
ID874_01780	COG0656	L-ascorbic acid biosynthetic process
ID874_01785	COG2267	carboxylic ester hydrolase activity
ID874_01795	COG2936	dipeptidyl-peptidase activity
ID874_01800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ID874_01805	COG2252	PERMEase
ID874_01810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ID874_01815	COG0531	amino acid
ID874_01830	COG0194	GDP metabolic process
ID874_01835	COG0735	belongs to the Fur family
ID874_01855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID874_01860	COG0765	amino acid transport
ID874_01865	COG0765	amino acid transport
ID874_01870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ID874_01875	COG0406	alpha-ribazole phosphatase activity
ID874_01880	COG0531	amino acid
ID874_01885	COG0588	phosphoglycerate mutase activity
ID874_01890	COG3973	AAA domain
ID874_01895	COG0028	Belongs to the TPP enzyme family
ID874_01900	COG3527	Alpha-acetolactate decarboxylase
ID874_01905	COG1072	(Pantothenic acid kinase))
ID874_01915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID874_01935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ID874_01935	COG0519	Catalyzes the synthesis of GMP from XMP
ID874_01945	COG0477	Major facilitator Superfamily
ID874_01950	COG0308	aminopeptidase N
ID874_01965	COG1518	maintenance of DNA repeat elements
ID874_01985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ID874_01990	COG0459	protein refolding
ID874_01995	COG0531	amino acid
ID874_02000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID874_02005	COG1739	Uncharacterized protein family UPF0029
ID874_02010	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ID874_02025	COG0653	protein targeting
ID874_02035	COG0745	RESPONSE REGULATOR receiver
ID874_02040	COG5002	protein histidine kinase activity
ID874_02050	COG0573	inorganic phosphate transmembrane transporter activity
ID874_02055	COG0581	inorganic phosphate transmembrane transporter activity
ID874_02065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ID874_02070	COG0704	Plays a role in the regulation of phosphate uptake
ID874_02080	COG1950	PFAM Membrane protein of
ID874_02085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ID874_02090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ID874_02095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ID874_02105	COG0492	ferredoxin-NADP+ reductase activity
ID874_02110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID874_02120	COG0556	nucleotide-excision repair
ID874_02125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ID874_02130	COG1660	Displays ATPase and GTPase activities
ID874_02135	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ID874_02140	COG1481	regulation of sporulation
ID874_02145	COG1705	Flagellar rod assembly protein muramidase FlgJ
ID874_02145	COG1388	LysM domain
ID874_02155	COG0740	serine-type endopeptidase activity
ID874_02165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ID874_02170	COG2390	Transcriptional regulator
ID874_02180	COG0126	phosphoglycerate kinase activity
ID874_02185	COG0149	triose-phosphate isomerase activity
ID874_02190	COG0148	phosphopyruvate hydratase activity
ID874_02195	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ID874_02200	COG0557	exoribonuclease II activity
ID874_02205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ID874_02220	COG0561	phosphatase activity
ID874_02225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ID874_02230	COG0802	atpase or kinase
ID874_02235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID874_02250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ID874_02255	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ID874_02265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID874_02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ID874_02290	COG1011	Hydrolase
ID874_02300	COG2188	Transcriptional regulator
ID874_02310	COG3715	PTS system
ID874_02315	COG3716	PTS system mannose fructose sorbose family IID component
ID874_02325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ID874_02335	COG3479	Phenolic acid decarboxylase
ID874_02340	COG1695	Transcriptional regulator
ID874_02345	COG1028	Short-chain dehydrogenase reductase Sdr
ID874_02355	COG4690	dipeptidase activity
ID874_02360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID874_02370	COG1122	ATPase activity
ID874_02405	COG1328	CTP reductase activity
ID874_02415	COG0396	ATPase activity
ID874_02420	COG0719	Fe-S assembly protein
ID874_02425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ID874_02430	COG0822	iron-sulfur transferase activity
ID874_02435	COG0719	Fe-S assembly protein
ID874_02440	COG2095	MarC family integral membrane protein
ID874_02445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ID874_02455	COG1694	Mazg nucleotide pyrophosphohydrolase
ID874_02460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID874_02470	COG1063	alcohol dehydrogenase
ID874_02495	COG1442	glycosyl transferase family 8
ID874_02590	COG3475	LICD family
ID874_02600	COG3397	chitin binding
ID874_02610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ID874_02615	COG0351	phosphomethylpyrimidine kinase
ID874_02620	COG0352	thiamine-phosphate diphosphorylase activity
ID874_02635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID874_02635	COG5549	protein import
ID874_02650	COG0489	protein tyrosine kinase activity
ID874_02655	COG4464	protein tyrosine phosphatase activity
ID874_02660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ID874_02670	COG3475	LICD family
ID874_02695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ID874_02705	COG1088	dTDP-glucose 4,6-dehydratase activity
ID874_02720	COG0438	transferase activity, transferring glycosyl groups
ID874_02725	COG2188	Transcriptional regulator
ID874_02740	COG3715	PTS system
ID874_02750	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
ID874_02750	COG3408	Glycogen debranching enzyme
ID874_02760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_02760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_02770	COG2723	6-phospho-beta-galactosidase activity
ID874_02775	COG3711	transcriptional antiterminator
ID874_02795	COG2188	Transcriptional regulator
ID874_02825	COG2217	Heavy metal translocating P-type atpase
ID874_02835	COG0531	amino acid
ID874_02850	COG0673	inositol 2-dehydrogenase activity
ID874_02855	COG0513	Belongs to the DEAD box helicase family
ID874_02860	COG1316	TRANSCRIPTIONal
ID874_02880	COG0516	GMP reductase activity
ID874_02885	COG0542	response to heat
ID874_02905	COG0596	Alpha beta hydrolase
ID874_02910	COG0438	transferase activity, transferring glycosyl groups
ID874_02915	COG0438	transferase activity, transferring glycosyl groups
ID874_03050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ID874_03055	COG0477	Major facilitator Superfamily
ID874_03060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ID874_03065	COG0671	phosphoesterase, PA-phosphatase related
ID874_03070	COG0495	leucyl-tRNA aminoacylation
ID874_03075	COG2244	polysaccharide biosynthetic process
ID874_03080	COG1187	pseudouridine synthase activity
ID874_03085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ID874_03090	COG0589	response to stress
ID874_03095	COG0154	amidase activity
ID874_03100	COG1428	Deoxynucleoside kinase
ID874_03135	COG0367	asparagine synthase
ID874_03140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ID874_03150	COG1794	racemase activity, acting on amino acids and derivatives
ID874_03160	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ID874_03165	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ID874_03200	COG1396	sequence-specific DNA binding
ID874_03265	COG0305	Participates in initiation and elongation during chromosome replication
ID874_03430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_03435	COG1940	carbohydrate kinase activity
ID874_03440	COG2723	6-phospho-beta-galactosidase activity
ID874_03460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID874_03460	COG3711	transcriptional antiterminator
ID874_03470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_03470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID874_03470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_03490	COG2017	converts alpha-aldose to the beta-anomer
ID874_03515	COG2160	L-arabinose isomerase activity
ID874_03530	COG0531	amino acid
ID874_03535	COG1297	OPT oligopeptide transporter protein
ID874_03570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_03595	COG1070	Carbohydrate kinase
ID874_03600	COG2814	Major facilitator Superfamily
ID874_03610	COG1309	transcriptional regulator
ID874_03630	COG1054	Belongs to the UPF0176 family
ID874_03635	COG1937	Protein conserved in bacteria
ID874_03665	COG2814	Major facilitator Superfamily
ID874_03670	COG1070	Carbohydrate kinase
ID874_03675	COG3254	rhamnose metabolic process
ID874_03680	COG4806	L-rhamnose isomerase
ID874_03685	COG0235	Class ii aldolase
ID874_03690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_03690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_03700	COG0383	alpha-mannosidase activity
ID874_03710	COG2723	6-phospho-beta-galactosidase activity
ID874_03730	COG2271	Major facilitator Superfamily
ID874_03735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID874_03740	COG3715	PTS system
ID874_03745	COG3716	PTS system mannose fructose sorbose family IID component
ID874_03755	COG2188	Transcriptional regulator
ID874_03795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ID874_03800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID874_03805	COG1609	Transcriptional regulator
ID874_03810	COG2017	converts alpha-aldose to the beta-anomer
ID874_03815	COG2190	(PTS) system
ID874_03815	COG2211	Major facilitator Superfamily
ID874_03830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ID874_03835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ID874_03840	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ID874_03850	COG0531	amino acid
ID874_03880	COG0667	Aldo Keto reductase
ID874_03885	COG0018	arginyl-trna synthetase
ID874_03895	COG1438	arginine binding
ID874_03900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID874_03905	COG3679	Belongs to the UPF0342 family
ID874_03910	COG0420	3'-5' exonuclease activity
ID874_03915	COG4717	serine-type aminopeptidase activity
ID874_03925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID874_03935	COG0537	adenosine 5'-monophosphoramidase activity
ID874_03940	COG1131	(ABC) transporter
ID874_03945	COG4473	ABC transporter
ID874_03950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ID874_03960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID874_03965	COG1674	ftsk spoiiie
ID874_03970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ID874_03975	COG0670	Belongs to the BI1 family
ID874_03980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID874_03980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID874_03985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ID874_03995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ID874_04005	COG1484	DNA-dependent DNA replication
ID874_04010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID874_04015	COG3275	phosphorelay sensor kinase activity
ID874_04020	COG3279	Response regulator of the LytR AlgR family
ID874_04030	COG1346	cytolysis
ID874_04035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ID874_04040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ID874_04045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ID874_04050	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ID874_04055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ID874_04060	COG1534	Rna-binding protein
ID874_04065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ID874_04070	COG1713	HD superfamily hydrolase involved in NAD metabolism
ID874_04075	COG0799	negative regulation of ribosome biogenesis
ID874_04080	COG2226	methyltransferase
ID874_04085	COG1323	Belongs to the UPF0348 family
ID874_04090	COG1399	metal-binding, possibly nucleic acid-binding protein
ID874_04095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ID874_04100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ID874_04105	COG0745	RESPONSE REGULATOR receiver
ID874_04110	COG5002	protein histidine kinase activity
ID874_04115	COG2814	Major facilitator Superfamily
ID874_04125	COG0706	membrane insertase activity
ID874_04130	COG1254	Belongs to the acylphosphatase family
ID874_04135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID874_04145	COG1733	regulation of RNA biosynthetic process
ID874_04150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ID874_04155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID874_04155	COG0072	phenylalanine-tRNA ligase activity
ID874_04160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ID874_04165	COG0572	uridine kinase
ID874_04170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID874_04175	COG4485	Bacterial membrane protein, YfhO
ID874_04180	COG0768	penicillin binding
ID874_04185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID874_04190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ID874_04195	COG0705	Rhomboid family
ID874_04205	COG1940	carbohydrate kinase activity
ID874_04210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID874_04220	COG0584	glycerophosphoryl diester phosphodiesterase
ID874_04225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ID874_04230	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ID874_04235	COG0789	Transcriptional regulator
ID874_04280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ID874_04290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ID874_04295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ID874_04300	COG1302	Protein conserved in bacteria
ID874_04305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID874_04310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ID874_04315	COG1570	exodeoxyribonuclease VII activity
ID874_04320	COG1722	exodeoxyribonuclease VII activity
ID874_04330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ID874_04335	COG1438	arginine binding
ID874_04340	COG0497	DNA recombination
ID874_04355	COG1758	RNA polymerase activity
ID874_04360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ID874_04365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ID874_04370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ID874_04375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID874_04375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ID874_04385	COG0515	serine threonine protein kinase
ID874_04385	COG2815	serine threonine protein kinase
ID874_04390	COG1162	GTPase activity
ID874_04395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ID874_04405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ID874_04420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ID874_04425	COG0416	fatty acid biosynthetic process
ID874_04430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID874_04435	COG0571	ribonuclease III activity
ID874_04440	COG1196	nuclear chromosome segregation
ID874_04445	COG0552	protein localization to endoplasmic reticulum
ID874_04450	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ID874_04455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ID874_04460	COG0228	four-way junction DNA binding
ID874_04465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ID874_04470	COG0336	Belongs to the RNA methyltransferase TrmD family
ID874_04475	COG4619	ABC transporter
ID874_04480	COG0390	transport system, permease component
ID874_04485	COG0335	large ribosomal subunit rRNA binding
ID874_04495	COG0393	Putative heavy-metal-binding
ID874_04505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ID874_04510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID874_04520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ID874_04525	COG1028	Short-chain dehydrogenase reductase Sdr
ID874_04530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID874_04535	COG0511	ligase activity, forming carbon-carbon bonds
ID874_04545	COG0439	Biotin carboxylase
ID874_04550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ID874_04555	COG0825	malonyl-CoA metabolic process
ID874_04560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ID874_04585	COG3425	synthase
ID874_04595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ID874_04600	COG4224	UPF0291 protein
ID874_04605	COG3763	UPF0154 protein
ID874_04610	COG0204	Acyl-transferase
ID874_04615	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ID874_04635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ID874_04640	COG0528	UMP kinase activity
ID874_04645	COG0233	cytoplasmic translational termination
ID874_04650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ID874_04655	COG4589	Belongs to the CDS family
ID874_04660	COG0750	zinc metalloprotease
ID874_04665	COG0442	prolyl-tRNA aminoacylation
ID874_04670	COG2176	DNA-directed DNA polymerase activity
ID874_04675	COG0779	Required for maturation of 30S ribosomal subunits
ID874_04680	COG0195	Participates in both transcription termination and antitermination
ID874_04685	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ID874_04695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ID874_04700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ID874_04705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ID874_04710	COG0196	riboflavin kinase activity
ID874_04715	COG1420	regulation of RNA biosynthetic process
ID874_04720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ID874_04725	COG0443	Heat shock 70 kDa protein
ID874_04730	COG0484	heat shock protein binding
ID874_04735	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ID874_04740	COG2155	Conserved Protein
ID874_04750	COG1131	(ABC) transporter
ID874_04765	COG0583	DNA-binding transcription factor activity
ID874_04770	COG2223	nitrite transmembrane transporter activity
ID874_04775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ID874_04780	COG4708	membrane
ID874_04790	COG1028	Short-chain dehydrogenase reductase Sdr
ID874_04805	COG0531	amino acid
ID874_04810	COG3250	beta-galactosidase activity
ID874_04835	COG1942	4-Oxalocrotonate Tautomerase
ID874_04840	COG0561	phosphatase activity
ID874_04845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ID874_04845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ID874_04850	COG1304	FMN binding
ID874_04870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ID874_04870	COG1199	ATP-dependent helicase activity
ID874_04880	COG3935	DnaD domain protein
ID874_04885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID874_04890	COG3331	DNA recombination
ID874_04895	COG4474	Belongs to the UPF0398 family
ID874_04900	COG3599	regulation of cell shape
ID874_04910	COG0116	Belongs to the methyltransferase superfamily
ID874_04915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ID874_04925	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ID874_04935	COG0564	pseudouridine synthase activity
ID874_04940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ID874_04950	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID874_04955	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ID874_04965	COG1307	EDD domain protein, DegV family
ID874_04975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ID874_04985	COG1609	Transcriptional regulator
ID874_04995	COG1288	antiporter activity
ID874_05000	COG1316	TRANSCRIPTIONal
ID874_05005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ID874_05010	COG2814	Major facilitator Superfamily
ID874_05020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ID874_05025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID874_05025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID874_05035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID874_05035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID874_05040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ID874_05045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ID874_05050	COG0285	dihydrofolate synthase activity
ID874_05055	COG0302	gtp cyclohydrolase
ID874_05060	COG0302	gtp cyclohydrolase
ID874_05060	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ID874_05080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID874_05085	COG1929	Belongs to the glycerate kinase type-1 family
ID874_05090	COG2610	gluconate transmembrane transporter activity
ID874_05095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ID874_05100	COG1227	inorganic diphosphatase activity
ID874_05105	COG0583	DNA-binding transcription factor activity
ID874_05110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ID874_05115	COG0187	DNA topoisomerase II activity
ID874_05130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ID874_05135	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ID874_05140	COG4974	Belongs to the 'phage' integrase family
ID874_05145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ID874_05150	COG0758	DNA mediated transformation
ID874_05155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ID874_05170	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID874_05175	COG0183	Belongs to the thiolase family
ID874_05195	COG1131	(ABC) transporter
ID874_05220	COG1309	transcriptional regulator
ID874_05225	COG0151	Belongs to the GarS family
ID874_05230	COG0138	bifunctional purine biosynthesis protein purh
ID874_05235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ID874_05240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ID874_05250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ID874_05255	COG0047	phosphoribosylformylglycinamidine synthase activity
ID874_05260	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ID874_05270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ID874_05275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ID874_05300	COG1131	(ABC) transporter
ID874_05305	COG1395	domain, Protein
ID874_05325	COG1132	(ABC) transporter
ID874_05330	COG1131	(ABC) transporter
ID874_05345	COG0352	thiamine-phosphate diphosphorylase activity
ID874_05355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID874_05360	COG2022	thiamine diphosphate biosynthetic process
ID874_05365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID874_05375	COG0105	UTP biosynthetic process
ID874_05425	COG2723	6-phospho-beta-galactosidase activity
ID874_05430	COG1263	PTS System
ID874_05430	COG2190	(PTS) system
ID874_05430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID874_05445	COG0531	amino acid
ID874_05450	COG1393	Belongs to the ArsC family
ID874_05460	COG0596	Alpha beta hydrolase
ID874_05480	COG3409	Peptidoglycan-binding domain 1 protein
ID874_05480	COG0793	Belongs to the peptidase S41A family
ID874_05485	COG4479	Belongs to the UPF0346 family
ID874_05495	COG2755	lipolytic protein G-D-S-L family
ID874_05500	COG1307	EDD domain protein, DegV family
ID874_05505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID874_05510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ID874_05515	COG0488	(ABC) transporter
ID874_05520	COG0617	tRNA 3'-terminal CCA addition
ID874_05525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID874_05540	COG0457	Tetratricopeptide repeat
ID874_05550	COG1160	GTP binding
ID874_05555	COG0539	negative regulation of cytoplasmic translation
ID874_05560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ID874_05570	COG0514	ATP-dependent DNA helicase (RecQ)
ID874_05580	COG1187	pseudouridine synthase activity
ID874_05585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ID874_05590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ID874_05610	COG2707	UPF0756 membrane protein
ID874_05620	COG0205	6-phosphofructokinase activity
ID874_05625	COG0587	DNA-directed DNA polymerase activity
ID874_05635	COG0542	response to heat
ID874_05640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ID874_05645	COG2384	SAM-dependent methyltransferase
ID874_05650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ID874_05655	COG0358	DNA primase activity
ID874_05660	COG0751	glycine-tRNA ligase activity
ID874_05665	COG0752	glycyl-tRNA synthetase alpha subunit
ID874_05670	COG1381	Involved in DNA repair and RecF pathway recombination
ID874_05675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ID874_05685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ID874_05690	COG1702	phosphate starvation-inducible protein PhoH
ID874_05700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ID874_05705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ID874_05715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ID874_05720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID874_05735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ID874_05740	COG0124	histidyl-tRNA synthetase
ID874_05750	COG0546	phosphoglycolate phosphatase activity
ID874_05755	COG1490	D-aminoacyl-tRNA deacylase activity
ID874_05760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ID874_05770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ID874_05775	COG2264	protein methyltransferase activity
ID874_05800	COG0436	Aminotransferase
ID874_05805	COG1088	dTDP-glucose 4,6-dehydratase activity
ID874_05815	COG2153	protein acetylation
ID874_05820	COG1132	(ABC) transporter
ID874_05825	COG0778	Nitroreductase
ID874_05850	COG1304	FMN binding
ID874_05975	COG5484	DNA packaging
ID874_05975	COG3728	DNA packaging
ID874_06025	COG0305	Participates in initiation and elongation during chromosome replication
ID874_06035	COG0629	single-stranded DNA binding
ID874_06080	COG1396	sequence-specific DNA binding
ID874_06135	COG2261	transglycosylase associated protein
ID874_06150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID874_06175	COG1131	(ABC) transporter
ID874_06190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID874_06195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ID874_06195	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ID874_06200	COG0300	oxidoreductase activity
ID874_06205	COG1234	tRNA 3'-trailer cleavage
ID874_06215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ID874_06220	COG0322	excinuclease ABC activity
ID874_06225	COG1126	abc transporter atp-binding protein
ID874_06230	COG0765	amino acid transport
ID874_06245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ID874_06250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ID874_06255	COG0544	peptidyl-prolyl cis-trans isomerase activity
ID874_06260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ID874_06275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ID874_06280	COG0268	Binds directly to 16S ribosomal RNA
ID874_06295	COG2131	deaminase
ID874_06300	COG1596	polysaccharide export
ID874_06300	COG1555	photosystem II stabilization
ID874_06305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ID874_06310	COG0742	ribosomal rna small subunit methyltransferase
ID874_06315	COG4471	UPF0298 protein
ID874_06320	COG0772	Belongs to the SEDS family
ID874_06325	COG1217	gtp-binding protein TYPA
ID874_06330	COG0483	inositol monophosphate 1-phosphatase activity
ID874_06335	COG4476	Belongs to the UPF0223 family
ID874_06340	COG0242	peptide deformylase activity
ID874_06350	COG5503	Protein of unknown function (DUF1447)
ID874_06365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_06365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID874_06365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID874_06370	COG1105	Belongs to the carbohydrate kinase PfkB family
ID874_06375	COG1349	DNA-binding transcription factor activity
ID874_06380	COG0628	permease
ID874_06385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ID874_06390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ID874_06405	COG0482	sulfurtransferase activity
ID874_06415	COG1104	cysteine desulfurase activity
ID874_06420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ID874_06430	COG0494	nUDIX hydrolase
ID874_06435	COG1278	Cold shock
ID874_06440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ID874_06445	COG3599	regulation of cell shape
ID874_06450	COG2302	S4 RNA-binding domain
ID874_06465	COG0849	cell division
ID874_06470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ID874_06475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ID874_06480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ID874_06485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID874_06490	COG0768	penicillin binding
ID874_06500	COG0275	rRNA processing
ID874_06505	COG2001	Belongs to the MraZ family
ID874_06515	COG1674	ftsk spoiiie
ID874_06525	COG0628	permease
ID874_06535	COG2706	6-phosphogluconolactonase activity
ID874_06540	COG3142	Participates in the control of copper homeostasis
ID874_06545	COG2239	Acts as a magnesium transporter
ID874_06550	COG0564	pseudouridine synthase activity
ID874_06555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ID874_06560	COG2357	RelA SpoT domain protein
ID874_06575	COG4862	establishment of competence for transformation
ID874_06580	COG1393	Belongs to the ArsC family
ID874_06585	COG1234	tRNA 3'-trailer cleavage
ID874_06660	COG1185	polyribonucleotide nucleotidyltransferase activity
ID874_06665	COG0586	Pfam SNARE associated Golgi protein
ID874_06675	COG0647	UMP catabolic process
ID874_06680	COG4470	Protein conserved in bacteria
ID874_06690	COG0827	DNA restriction-modification system
ID874_06715	COG4537	Required for transformation and DNA binding
ID874_06720	COG1459	type II secretion system
ID874_06725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ID874_06735	COG0217	transcriptional regulatory protein
ID874_06740	COG2132	Multicopper oxidase
ID874_06745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ID874_06750	COG1335	isochorismatase
ID874_06755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ID874_06760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ID874_06780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ID874_06785	COG1609	Transcriptional regulator
ID874_06790	COG0006	proline dipeptidase activity
ID874_06805	COG0668	transmembrane transport
ID874_06810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ID874_06815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ID874_06820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ID874_06820	COG0574	Belongs to the PEP-utilizing enzyme family
ID874_06825	COG3118	belongs to the thioredoxin family
ID874_06830	COG1193	negative regulation of DNA recombination
ID874_06835	COG3906	Belongs to the UPF0473 family
ID874_06840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ID874_06845	COG4472	Bacterial protein of unknown function (DUF965)
ID874_06850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ID874_06855	COG0513	Belongs to the DEAD box helicase family
ID874_06860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ID874_06865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID874_06870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ID874_06875	COG1862	Preprotein translocase
ID874_06880	COG0343	queuine tRNA-ribosyltransferase activity
ID874_06885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ID874_06890	COG2255	four-way junction helicase activity
ID874_06895	COG0632	four-way junction helicase activity
ID874_06900	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ID874_06905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID874_06910	COG1418	mRNA catabolic process
ID874_06920	COG1058	Belongs to the CinA family
ID874_06920	COG1546	Belongs to the CinA family
ID874_06925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ID874_06935	COG0300	oxidoreductase activity
ID874_06940	COG0612	Peptidase, M16
ID874_06945	COG0612	Peptidase, M16
ID874_06950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID874_06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID874_06960	COG1126	abc transporter atp-binding protein
ID874_06965	COG0765	amino acid transport
ID874_06980	COG2003	Belongs to the UPF0758 family
ID874_06985	COG0285	dihydrofolate synthase activity
ID874_06990	COG0525	valine-tRNA ligase activity
ID874_07000	COG0301	tRNA thio-modification
ID874_07005	COG1104	cysteine desulfurase activity
ID874_07010	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ID874_07015	COG1956	GAF domain-containing protein
ID874_07020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ID874_07025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ID874_07040	COG0589	response to stress
ID874_07050	COG1181	Belongs to the D-alanine--D-alanine ligase family
ID874_07060	COG0531	amino acid
ID874_07075	COG1131	(ABC) transporter
ID874_07080	COG1725	Transcriptional regulator
ID874_07085	COG1464	Belongs to the NlpA lipoprotein family
ID874_07090	COG2011	ABC-type metal ion transport system permease component
ID874_07095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ID874_07100	COG0772	Belongs to the SEDS family
ID874_07110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ID874_07115	COG4836	Membrane
ID874_07120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ID874_07125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ID874_07130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ID874_07135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ID874_07140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID874_07145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ID874_07150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID874_07155	COG0356	it plays a direct role in the translocation of protons across the membrane
ID874_07170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ID874_07175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ID874_07180	COG0009	L-threonylcarbamoyladenylate synthase
ID874_07185	COG2890	protein-(glutamine-N5) methyltransferase activity
ID874_07195	COG1435	thymidine kinase activity
ID874_07200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ID874_07205	COG3442	glutamine amidotransferase
ID874_07210	COG1482	cell wall glycoprotein biosynthetic process
ID874_07220	COG1132	(ABC) transporter
ID874_07240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID874_07260	COG1053	succinate dehydrogenase
ID874_07260	COG0431	NADPH-dependent FMN reductase
ID874_07260	COG3976	FMN-binding domain protein
ID874_07265	COG0431	NADPH-dependent FMN reductase
ID874_07265	COG3976	FMN-binding domain protein
ID874_07265	COG1053	succinate dehydrogenase
ID874_07275	COG0166	Belongs to the GPI family
ID874_07280	COG4975	Glucose uptake
ID874_07290	COG5002	protein histidine kinase activity
ID874_07290	COG3850	Histidine kinase
ID874_07295	COG0745	RESPONSE REGULATOR receiver
ID874_07310	COG0741	lytic transglycosylase activity
ID874_07320	COG2610	gluconate transmembrane transporter activity
ID874_07325	COG1070	Carbohydrate kinase
ID874_07330	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ID874_07335	COG1737	Transcriptional regulator
ID874_07360	COG1073	alpha beta
ID874_07375	COG0653	protein targeting
ID874_07395	COG0730	response to heat
ID874_07400	COG1368	sulfuric ester hydrolase activity
ID874_07405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ID874_07410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ID874_07415	COG0628	permease
ID874_07420	COG3557	Belongs to the UPF0374 family
ID874_07425	COG2137	regulation of response to DNA damage stimulus
ID874_07430	COG0716	FMN binding
ID874_07440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID874_07445	COG1597	lipid kinase activity
ID874_07450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID874_07455	COG0154	amidase activity
ID874_07465	COG4851	CamS sex pheromone cAM373 precursor
ID874_07475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ID874_07480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID874_07485	COG1705	Flagellar rod assembly protein muramidase FlgJ
ID874_07520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID874_07535	COG0531	amino acid
ID874_07550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ID874_07555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ID874_07570	COG1122	ATPase activity
ID874_07575	COG1122	ATPase activity
ID874_07580	COG0203	ribosomal protein L17
ID874_07585	COG0202	RNA polymerase activity
ID874_07590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ID874_07595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ID874_07600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ID874_07605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ID874_07620	COG0200	Binds to the 23S rRNA
ID874_07625	COG1841	ribosomal large subunit assembly
ID874_07630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ID874_07635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ID874_07640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ID874_07645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ID874_07650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID874_07655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ID874_07660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ID874_07665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ID874_07675	COG0255	Belongs to the universal ribosomal protein uL29 family
ID874_07680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ID874_07685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ID874_07690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ID874_07695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ID874_07700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ID874_07705	COG0089	rRNA binding
ID874_07710	COG0088	Forms part of the polypeptide exit tunnel
ID874_07715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ID874_07720	COG0051	transcription antitermination factor activity, RNA binding
ID874_07725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ID874_07730	COG0049	tRNA binding
ID874_07735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ID874_07745	COG1957	nucleoside hydrolase
ID874_07750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ID874_07755	COG0085	RNA polymerase activity
ID874_07760	COG0542	response to heat
ID874_07765	COG4463	regulation of RNA biosynthetic process
ID874_07770	COG0028	Belongs to the TPP enzyme family
ID874_07810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ID874_07815	COG1428	Deoxynucleoside kinase
ID874_07820	COG0833	amino acid
ID874_07835	COG1316	TRANSCRIPTIONal
ID874_07845	COG2966	Psort location CytoplasmicMembrane, score
ID874_07850	COG1278	Cold shock
ID874_07855	COG1230	cation diffusion facilitator family transporter
ID874_07865	COG1418	mRNA catabolic process
ID874_07870	COG1418	mRNA catabolic process
ID874_07880	COG0564	pseudouridine synthase activity
ID874_07900	COG4690	dipeptidase activity
ID874_07910	COG4152	abc transporter atp-binding protein
ID874_07915	COG1476	TRANSCRIPTIONal
ID874_07940	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ID874_07950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ID874_07960	COG1214	PFAM Peptidase M22, glycoprotease
ID874_07965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ID874_07980	COG4467	Involved in initiation control of chromosome replication
ID874_07985	COG0470	DNA polymerase III
ID874_07990	COG3870	Protein conserved in bacteria
ID874_07995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ID874_08000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ID874_08005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ID874_08010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ID874_08025	COG2813	Specifically methylates the guanine in position
ID874_08030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ID874_08035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID874_08040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID874_08045	COG0222	ribosome binding
ID874_08050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ID874_08055	COG0081	regulation of translation
ID874_08065	COG0250	Participates in transcription elongation, termination and antitermination
ID874_08075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID874_08085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID874_08090	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ID874_08095	COG0215	cysteine-tRNA ligase activity
ID874_08100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ID874_08105	COG4956	integral membrane protein (PIN domain superfamily)
ID874_08125	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ID874_08135	COG0588	phosphoglycerate mutase activity
ID874_08140	COG0825	malonyl-CoA metabolic process
ID874_08150	COG0439	Biotin carboxylase
ID874_08160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID874_08175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ID874_08175	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ID874_08185	COG3716	PTS system mannose fructose sorbose family IID component
ID874_08190	COG3715	PTS system
ID874_08205	COG3091	SprT-like family
ID874_08210	COG2183	response to ionizing radiation
ID874_08230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ID874_08235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ID874_08240	COG2188	Transcriptional regulator
ID874_08250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID874_08275	COG3104	oligopeptide transport
ID874_08315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ID874_08320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ID874_08325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ID874_08340	COG0037	tRNA processing
ID874_08345	COG1098	S1 RNA binding domain
ID874_08355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ID874_08360	COG2244	polysaccharide biosynthetic process
ID874_08365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ID874_08370	COG0193	aminoacyl-tRNA hydrolase activity
ID874_08390	COG2337	Toxic component of a toxin-antitoxin (TA) module
ID874_08415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ID874_08425	COG0501	Belongs to the peptidase M48B family
ID874_08430	COG1704	LemA family
ID874_08435	COG3764	Sortase (surface protein transpeptidase)
ID874_08445	COG0254	rRNA binding
ID874_08450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ID874_08455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID874_08460	COG0504	CTP synthase activity
ID874_08465	COG3343	RNA polymerase activity
ID874_08475	COG1078	dGTPase activity
ID874_08485	COG1940	carbohydrate kinase activity
ID874_08500	COG0534	Mate efflux family protein
ID874_08515	COG0546	phosphoglycolate phosphatase activity
ID874_08525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID874_08530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ID874_08535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID874_08540	COG1696	Membrane protein involved in D-alanine export
ID874_08545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID874_08555	COG1268	BioY protein
ID874_08560	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ID874_08570	COG2814	Major facilitator Superfamily
ID874_08580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID874_08585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID874_08595	COG0463	Glycosyl transferase, family 2
ID874_08600	COG0463	Glycosyl transferase, family 2
ID874_08600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID874_08605	COG1134	teichoic acid transport
ID874_08610	COG1682	transport, permease protein
ID874_08620	COG0463	Glycosyl transferase, family 2
ID874_08625	COG2246	polysaccharide biosynthetic process
ID874_08630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ID874_08635	COG0708	Exodeoxyribonuclease III
ID874_08645	COG1193	negative regulation of DNA recombination
ID874_08660	COG0114	fumarate hydratase activity
ID874_08670	COG0583	DNA-binding transcription factor activity
ID874_08675	COG0667	Aldo Keto reductase
ID874_08690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ID874_08695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ID874_08700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ID874_08745	COG1164	Oligoendopeptidase f
ID874_08760	COG2211	Major facilitator Superfamily
ID874_08765	COG2814	Major facilitator Superfamily
ID874_08770	COG1854	S-ribosylhomocysteine lyase activity
ID874_08775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ID874_08780	COG0110	maltose O-acetyltransferase activity
ID874_08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID874_08800	COG0105	UTP biosynthetic process
ID874_08805	COG0697	spore germination
ID874_08815	COG0488	(ABC) transporter
ID874_08825	COG0402	S-adenosylhomocysteine deaminase activity
ID874_08830	COG0577	efflux transmembrane transporter activity
ID874_08830	COG1136	(ABC) transporter
ID874_08835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ID874_08840	COG1174	glycine betaine transport
ID874_08845	COG1732	Glycine betaine
ID874_08870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ID874_08880	COG0732	type I restriction modification DNA specificity domain
ID874_08900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ID874_08905	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ID874_08910	COG1461	Dihydroxyacetone kinase
ID874_08915	COG2376	Dihydroxyacetone kinase
ID874_08920	COG2357	RelA SpoT domain protein
ID874_08930	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID874_08960	COG2261	transglycosylase associated protein
ID874_08965	COG0667	Aldo Keto reductase
ID874_08970	COG0561	phosphatase activity
ID874_08975	COG0284	orotidine-5'-phosphate decarboxylase activity
ID874_08980	COG0242	peptide deformylase activity
ID874_08990	COG1846	Transcriptional regulator
ID874_09005	COG1131	(ABC) transporter
ID874_09010	COG0789	Transcriptional regulator
ID874_09015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ID874_09030	COG1902	pentaerythritol trinitrate reductase activity
ID874_09035	COG4975	Glucose uptake
ID874_09040	COG1869	D-ribose catabolic process
ID874_09050	COG1609	Transcriptional regulator
ID874_09055	COG1914	H( )-stimulated, divalent metal cation uptake system
ID874_09090	COG0702	epimerase
ID874_09105	COG0588	phosphoglycerate mutase activity
ID874_09110	COG0148	phosphopyruvate hydratase activity
ID874_09120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ID874_09140	COG1686	Belongs to the peptidase S11 family
ID874_09145	COG5002	protein histidine kinase activity
ID874_09150	COG0745	RESPONSE REGULATOR receiver
ID874_09155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ID874_09170	COG0012	GTP binding
ID874_09175	COG4481	Protein conserved in bacteria
ID874_09180	COG1475	DNA binding
ID874_09185	COG0357	Ribosomal RNA small subunit methyltransferase G
ID874_09200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ID874_09210	COG0791	NLP P60 protein
ID874_09220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID874_09225	COG2197	response regulator
ID874_09230	COG4585	Histidine kinase
ID874_09235	COG0842	Transport permease protein
ID874_09245	COG0586	Pfam SNARE associated Golgi protein
ID874_09265	COG4555	ABC transporter
ID874_09275	COG1695	Transcriptional regulator
ID874_09280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ID874_09280	COG2755	lipolytic protein G-D-S-L family
ID874_09295	COG1136	(ABC) transporter
ID874_09315	COG2200	EAL domain
ID874_09330	COG3507	Belongs to the glycosyl hydrolase 43 family
ID874_09335	COG2211	Major facilitator Superfamily
ID874_09350	COG2115	Belongs to the xylose isomerase family
ID874_09365	COG2017	converts alpha-aldose to the beta-anomer
ID874_09385	COG2222	sugar isomerase
ID874_09390	COG2188	Transcriptional regulator
ID874_09395	COG3716	PTS system mannose fructose sorbose family IID component
ID874_09400	COG3715	PTS system
ID874_09405	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID874_09435	COG4708	membrane
ID874_09440	COG0604	alcohol dehydrogenase
ID874_09465	COG0095	Lipoate-protein ligase
ID874_09470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_09475	COG2723	6-phospho-beta-galactosidase activity
ID874_09480	COG2188	Transcriptional regulator
ID874_09490	COG1511	domain protein
ID874_09490	COG1511	domain protein
ID874_09495	COG0640	Transcriptional regulator
ID874_09510	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ID874_09515	COG1609	Transcriptional regulator
ID874_09530	COG3279	Response regulator of the LytR AlgR family
ID874_09565	COG0604	alcohol dehydrogenase
ID874_09575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID874_09580	COG0246	Mannitol dehydrogenase
ID874_09585	COG1904	glucuronate isomerase
ID874_09600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ID874_09605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID874_09610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ID874_09630	COG0745	RESPONSE REGULATOR receiver
ID874_09645	COG0667	Aldo Keto reductase
ID874_09670	COG3321	synthase
ID874_09670	COG0604	alcohol dehydrogenase
ID874_09675	COG0640	Transcriptional regulator
ID874_09725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_09730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_09730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_09735	COG1609	Transcriptional regulator
ID874_09745	COG1970	mechanosensitive ion channel activity
ID874_09755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ID874_09775	COG1136	(ABC) transporter
ID874_09775	COG0577	efflux transmembrane transporter activity
ID874_09795	COG2832	Protein of unknown function (DUF454)
ID874_09810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ID874_09815	COG1074	ATP-dependent DNA helicase activity
ID874_09820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ID874_09835	COG0519	Catalyzes the synthesis of GMP from XMP
ID874_09845	COG1757	Na H antiporter
ID874_09850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID874_09855	COG0537	adenosine 5'-monophosphoramidase activity
ID874_09865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID874_09875	COG1446	asparaginase
ID874_09885	COG2188	Transcriptional regulator
ID874_09890	COG3022	response to hydroperoxide
ID874_09895	COG0445	tRNA wobble uridine modification
ID874_09900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ID874_09905	COG0706	membrane insertase activity
ID874_09910	COG0594	ribonuclease P activity
ID874_09915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ID874_09920	COG1192	Involved in chromosome partitioning
ID874_09965	COG4166	transmembrane transport
ID874_09970	COG0601	transmembrane transport
ID874_09975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID874_09980	COG0444	Belongs to the ABC transporter superfamily
ID874_09985	COG4608	Belongs to the ABC transporter superfamily
ID874_10040	COG2801	Transposase and inactivated derivatives
ID874_10060	COG2918	glutathione biosynthetic process
ID874_10060	COG1181	Belongs to the D-alanine--D-alanine ligase family
ID874_10065	COG1113	amino acid transport
ID874_10075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ID874_10100	COG3189	MarR family transcriptional regulator
ID874_10140	COG1940	carbohydrate kinase activity
ID874_10145	COG1609	Transcriptional regulator
ID874_10150	COG2223	nitrite transmembrane transporter activity
ID874_10155	COG1621	beta-fructofuranosidase activity
ID874_10160	COG0640	Transcriptional regulator
ID874_10170	COG3118	belongs to the thioredoxin family
ID874_10175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID874_10185	COG0492	ferredoxin-NADP+ reductase activity
ID874_10195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID874_10210	COG0582	viral genome integration into host DNA
ID874_10245	COG2223	nitrite transmembrane transporter activity
ID874_10250	COG1621	beta-fructofuranosidase activity
ID874_10255	COG0640	Transcriptional regulator
ID874_10265	COG3118	belongs to the thioredoxin family
ID874_10270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID874_10280	COG0492	ferredoxin-NADP+ reductase activity
ID874_10290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID874_10305	COG0582	viral genome integration into host DNA
ID874_10325	COG2963	transposase activity