locus-tag	class	description
CW731_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CW731_00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CW731_00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CW731_00030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CW731_00035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CW731_00040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CW731_00065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW731_00170	COG4206	TonB-dependent receptor
CW731_00170	COG1629	transport
CW731_00180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CW731_00185	COG0602	queuosine metabolic process
CW731_00190	COG0539	negative regulation of cytoplasmic translation
CW731_00195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW731_00245	COG2197	response regulator
CW731_00250	COG2197	response regulator
CW731_00255	COG4585	Histidine kinase
CW731_00280	COG1082	Xylose isomerase domain protein TIM barrel
CW731_00300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CW731_00305	COG3537	Alpha-1,2-mannosidase
CW731_00330	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CW731_00340	COG3537	Alpha-1,2-mannosidase
CW731_00345	COG3275	phosphorelay sensor kinase activity
CW731_00350	COG3279	Response regulator of the LytR AlgR family
CW731_00360	COG1629	transport
CW731_00360	COG4206	TonB-dependent receptor
CW731_00365	COG3250	beta-galactosidase activity
CW731_00370	COG3345	alpha-galactosidase
CW731_00375	COG3250	beta-galactosidase activity
CW731_00380	COG3119	arylsulfatase activity
CW731_00385	COG3119	arylsulfatase activity
CW731_00395	COG3119	arylsulfatase activity
CW731_00400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CW731_00405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CW731_00410	COG2234	aminopeptidase activity
CW731_00425	COG1629	transport
CW731_00425	COG4206	TonB-dependent receptor
CW731_00430	COG0561	phosphatase activity
CW731_00445	COG1629	transport
CW731_00445	COG4206	TonB-dependent receptor
CW731_00455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW731_00460	COG2186	Transcriptional regulator
CW731_00480	COG3345	alpha-galactosidase
CW731_00500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW731_00505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CW731_00515	COG2363	Small membrane protein
CW731_00520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CW731_00565	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CW731_00570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CW731_00575	COG0022	dehydrogenase e1 component
CW731_00575	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW731_00580	COG2086	electron transfer activity
CW731_00585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CW731_00595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CW731_00600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CW731_00610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CW731_00620	COG0519	Catalyzes the synthesis of GMP from XMP
CW731_00650	COG2936	dipeptidyl-peptidase activity
CW731_00660	COG1032	radical SAM domain protein
CW731_00670	COG3275	phosphorelay sensor kinase activity
CW731_00700	COG1595	DNA-templated transcription, initiation
CW731_00745	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CW731_00750	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CW731_00770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW731_00775	COG0018	arginyl-trna synthetase
CW731_00785	COG3876	Protein conserved in bacteria
CW731_00805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CW731_00835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CW731_00840	COG0436	Aminotransferase
CW731_00845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CW731_00855	COG0525	valine-tRNA ligase activity
CW731_00870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CW731_00910	COG0321	lipoyl(octanoyl) transferase activity
CW731_00910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CW731_00940	COG0513	Belongs to the DEAD box helicase family
CW731_00950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CW731_00985	COG1136	(ABC) transporter
CW731_00995	COG0045	succinate-CoA ligase (ADP-forming) activity
CW731_01010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CW731_01015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CW731_01040	COG4206	TonB-dependent receptor
CW731_01040	COG1629	transport
CW731_01055	COG0556	nucleotide-excision repair
CW731_01070	COG1131	(ABC) transporter
CW731_01085	COG1169	isochorismate synthase
CW731_01095	COG1132	(ABC) transporter
CW731_01100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW731_01120	COG0237	dephospho-CoA kinase activity
CW731_01135	COG0009	L-threonylcarbamoyladenylate synthase
CW731_01170	COG1022	Amp-dependent synthetase and ligase
CW731_01180	COG4191	Histidine kinase
CW731_01185	COG2204	response regulator
CW731_01195	COG1136	(ABC) transporter
CW731_01220	COG0047	phosphoribosylformylglycinamidine synthase activity
CW731_01220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CW731_01225	COG5297	Belongs to the glycosyl hydrolase family 6
CW731_01235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW731_01235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CW731_01240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CW731_01260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CW731_01270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW731_01275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CW731_01285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CW731_01295	COG0012	GTP binding
CW731_01330	COG0673	inositol 2-dehydrogenase activity
CW731_01350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CW731_01355	COG0006	proline dipeptidase activity
CW731_01360	COG0702	epimerase
CW731_01365	COG4628	conserved protein (DUF2132)
CW731_01385	COG2183	response to ionizing radiation
CW731_01395	COG0019	diaminopimelate decarboxylase activity
CW731_01455	COG0210	DNA helicase
CW731_01465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CW731_01475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CW731_01480	COG0484	heat shock protein binding
CW731_01515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW731_01525	COG0076	glutamate decarboxylase activity
CW731_01535	COG1959	2 iron, 2 sulfur cluster binding
CW731_01555	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CW731_01570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CW731_01605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW731_01610	COG1228	amidohydrolase
CW731_01615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CW731_01635	COG3959	Transketolase, thiamine diphosphate binding domain
CW731_01640	COG0438	transferase activity, transferring glycosyl groups
CW731_01650	COG1301	dicarboxylic acid transport
CW731_01675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW731_01680	COG3011	Protein conserved in bacteria
CW731_01685	COG1136	(ABC) transporter
CW731_01690	COG1136	(ABC) transporter
CW731_01690	COG0577	efflux transmembrane transporter activity
CW731_01695	COG0577	efflux transmembrane transporter activity
CW731_01755	COG1132	(ABC) transporter
CW731_01765	COG1278	Cold shock
CW731_01770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CW731_01790	COG2249	NAD(P)H dehydrogenase (quinone) activity
CW731_01800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CW731_01810	COG0351	phosphomethylpyrimidine kinase
CW731_01815	COG0352	thiamine-phosphate diphosphorylase activity
CW731_01820	COG2022	thiamine diphosphate biosynthetic process
CW731_01825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CW731_01890	COG0516	GMP reductase activity
CW731_01890	COG0517	IMP dehydrogenase activity
CW731_01900	COG1012	belongs to the aldehyde dehydrogenase family
CW731_01920	COG1733	regulation of RNA biosynthetic process
CW731_01930	COG0401	homolog of Blt101
CW731_01935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW731_01960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CW731_01965	COG0066	3-isopropylmalate dehydratase activity
CW731_01970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CW731_01975	COG0473	3-isopropylmalate dehydrogenase activity
CW731_01980	COG0798	PFAM Bile acid sodium symporter
CW731_01995	COG0640	Transcriptional regulator
CW731_02000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW731_02020	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW731_02060	COG3340	Belongs to the peptidase S51 family
CW731_02065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW731_02065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW731_02080	COG1674	ftsk spoiiie
CW731_02090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CW731_02095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW731_02100	COG0534	Mate efflux family protein
CW731_02115	COG4325	translation initiation factor activity
CW731_02120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CW731_02125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW731_02145	COG4206	TonB-dependent receptor
CW731_02160	COG0215	cysteine-tRNA ligase activity
CW731_02165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CW731_02170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CW731_02200	COG0667	Aldo Keto reductase
CW731_02205	COG0247	lactate metabolic process
CW731_02205	COG0277	FAD linked oxidase domain protein
CW731_02215	COG0419	ATPase involved in DNA repair
CW731_02220	COG0420	3'-5' exonuclease activity
CW731_02225	COG1193	negative regulation of DNA recombination
CW731_02235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CW731_02255	COG0813	purine-nucleoside phosphorylase activity
CW731_02280	COG2154	pterin-4-alpha-carbinolamine dehydratase
CW731_02285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CW731_02290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW731_02305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CW731_02325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CW731_02330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CW731_02335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CW731_02340	COG0131	Imidazoleglycerol-phosphate dehydratase
CW731_02350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CW731_02355	COG0107	imidazoleglycerol-phosphate synthase activity
CW731_02365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CW731_02365	COG0140	phosphoribosyl-ATP diphosphatase activity
CW731_02380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CW731_02395	COG0542	response to heat
CW731_02415	COG0010	Belongs to the arginase family
CW731_02420	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CW731_02430	COG3153	acetyltransferase
CW731_02430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW731_02445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CW731_02460	COG1322	Protein conserved in bacteria
CW731_02470	COG2195	Cleaves the N-terminal amino acid of tripeptides
CW731_02495	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CW731_02505	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CW731_02545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW731_02545	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CW731_02575	COG2378	regulation of single-species biofilm formation
CW731_02610	COG1522	sequence-specific DNA binding
CW731_02615	COG0022	dehydrogenase e1 component
CW731_02620	COG2130	NADP-dependent
CW731_02630	COG0564	pseudouridine synthase activity
CW731_02640	COG2814	Major facilitator Superfamily
CW731_02645	COG3152	Membrane
CW731_02655	COG0714	Associated with various cellular activities
CW731_02675	COG1714	RDD family
CW731_02680	COG0737	Belongs to the 5'-nucleotidase family
CW731_02685	COG0737	Belongs to the 5'-nucleotidase family
CW731_02700	COG1136	(ABC) transporter
CW731_02710	COG0302	gtp cyclohydrolase
CW731_02750	COG3275	phosphorelay sensor kinase activity
CW731_02755	COG3279	Response regulator of the LytR AlgR family
CW731_02760	COG3118	belongs to the thioredoxin family
CW731_02825	COG2755	lipolytic protein G-D-S-L family
CW731_02825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CW731_02835	COG0671	phosphoesterase, PA-phosphatase related
CW731_02840	COG2259	Doxx family
CW731_02955	COG4181	ATPase activity
CW731_02975	COG2095	MarC family integral membrane protein
CW731_02980	COG2217	Heavy metal translocating P-type atpase
CW731_03010	COG0352	thiamine-phosphate diphosphorylase activity
CW731_03015	COG0668	transmembrane transport
CW731_03020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CW731_03025	COG1064	alcohol dehydrogenase
CW731_03030	COG1764	response to oxidative stress
CW731_03035	COG1902	pentaerythritol trinitrate reductase activity
CW731_03050	COG1309	transcriptional regulator
CW731_03060	COG2130	NADP-dependent
CW731_03065	COG1979	alcohol dehydrogenase
CW731_03090	COG1505	serine-type exopeptidase activity
CW731_03110	COG0513	Belongs to the DEAD box helicase family
CW731_03120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW731_03130	COG0424	maF-like protein
CW731_03135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CW731_03155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CW731_03160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CW731_03245	COG1028	Short-chain dehydrogenase reductase Sdr
CW731_03250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CW731_03265	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CW731_03270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW731_03275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW731_03275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CW731_03280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW731_03285	COG1078	dGTPase activity
CW731_03290	COG2204	response regulator
CW731_03295	COG0802	atpase or kinase
CW731_03315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CW731_03325	COG0359	binds to the 23S rRNA
CW731_03330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CW731_03335	COG0360	Binds together with S18 to 16S ribosomal RNA
CW731_03355	COG1595	DNA-templated transcription, initiation
CW731_03365	COG0579	oxidoreductase
CW731_03370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CW731_03375	COG0116	Belongs to the methyltransferase superfamily
CW731_03390	COG0514	ATP-dependent DNA helicase (RecQ)
CW731_03395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CW731_03395	COG0517	IMP dehydrogenase activity
CW731_03400	COG0805	protein transport
CW731_03410	COG1137	ATPase activity
CW731_03415	COG1183	phosphatidylcholine synthase activity
CW731_03435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CW731_03440	COG1215	transferase activity, transferring glycosyl groups
CW731_03470	COG0438	transferase activity, transferring glycosyl groups
CW731_03480	COG1083	cytidylyl-transferase
CW731_03490	COG2089	acid synthase
CW731_03510	COG1216	Glycosyl transferase, family 2
CW731_03515	COG1215	transferase activity, transferring glycosyl groups
CW731_03520	COG1216	Glycosyl transferase, family 2
CW731_03520	COG0463	Glycosyl transferase, family 2
CW731_03555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CW731_03575	COG4974	Belongs to the 'phage' integrase family
CW731_03600	COG1418	mRNA catabolic process
CW731_03635	COG3850	Histidine kinase
CW731_03645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CW731_03650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CW731_03670	COG1595	DNA-templated transcription, initiation
CW731_03675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CW731_03685	COG4206	TonB-dependent receptor
CW731_03705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CW731_03720	COG3275	phosphorelay sensor kinase activity
CW731_03725	COG1408	metallophosphoesterase
CW731_03730	COG3279	Response regulator of the LytR AlgR family
CW731_03740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CW731_03765	COG1119	ATPase activity
CW731_03770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CW731_03780	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW731_03800	COG0783	Belongs to the Dps family
CW731_03810	COG0488	(ABC) transporter
CW731_03830	COG0167	dihydroorotate dehydrogenase activity
CW731_03850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW731_03855	COG0545	Peptidyl-prolyl cis-trans isomerase
CW731_03865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CW731_03875	COG0105	UTP biosynthetic process
CW731_03880	COG1846	Transcriptional regulator
CW731_03890	COG0251	oxidation-reduction process
CW731_03905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CW731_03915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CW731_03925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CW731_03950	COG2329	Antibiotic biosynthesis monooxygenase
CW731_03960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW731_03980	COG1278	Cold shock
CW731_03985	COG1278	Cold shock
CW731_04000	COG0482	sulfurtransferase activity
CW731_04020	COG2346	COG2346, Truncated hemoglobins
CW731_04025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW731_04040	COG0861	Integral membrane protein TerC family
CW731_04050	COG4771	TonB-dependent receptor
CW731_04060	COG2270	Major facilitator Superfamily
CW731_04070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW731_04075	COG1288	antiporter activity
CW731_04115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CW731_04120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CW731_04125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CW731_04150	COG0433	COG0433 Predicted ATPase
CW731_04155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CW731_04160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CW731_04165	COG3279	Response regulator of the LytR AlgR family
CW731_04190	COG3275	phosphorelay sensor kinase activity
CW731_04205	COG0137	argininosuccinate synthase activity
CW731_04210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CW731_04220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW731_04230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CW731_04240	COG0165	Argininosuccinate lyase
CW731_04265	COG1233	COG1233 Phytoene dehydrogenase and related
CW731_04290	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CW731_04300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW731_04305	COG1393	Belongs to the ArsC family
CW731_04320	COG0590	tRNA wobble adenosine to inosine editing
CW731_04330	COG0489	protein tyrosine kinase activity
CW731_04355	COG0653	protein targeting
CW731_04360	COG0302	gtp cyclohydrolase
CW731_04365	COG0124	histidyl-tRNA synthetase
CW731_04370	COG1295	ribonuclease BN
CW731_04380	COG3015	lipoprotein NlpE involved in copper resistance
CW731_04385	COG0339	signal peptide processing
CW731_04395	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CW731_04405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CW731_04410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CW731_04415	COG1120	ATPase activity
CW731_04430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW731_04435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CW731_04440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW731_04445	COG3263	regulation of cellular component size
CW731_04455	COG0659	secondary active sulfate transmembrane transporter activity
CW731_04475	COG0783	Belongs to the Dps family
CW731_04480	COG0668	transmembrane transport
CW731_04485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CW731_04495	COG4771	TonB-dependent receptor
CW731_04530	COG0584	glycerophosphoryl diester phosphodiesterase
CW731_04545	COG4206	TonB-dependent receptor
CW731_04545	COG1629	transport
CW731_04605	COG1127	ABC transporter
CW731_04610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW731_04620	COG1301	dicarboxylic acid transport
CW731_04630	COG1272	protein, Hemolysin III
CW731_04635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CW731_04640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CW731_04650	COG0577	efflux transmembrane transporter activity
CW731_04650	COG1136	(ABC) transporter
CW731_04675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CW731_04690	COG0450	alkyl hydroperoxide reductase
CW731_04695	COG5002	protein histidine kinase activity
CW731_04740	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW731_04740	COG1024	Enoyl-CoA hydratase
CW731_04755	COG0366	Alpha amylase catalytic
CW731_04765	COG1501	Belongs to the glycosyl hydrolase 31 family
CW731_04775	COG0366	Alpha amylase catalytic
CW731_04780	COG1554	hydrolase, family 65, central catalytic
CW731_04785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW731_04800	COG1629	transport
CW731_04800	COG4206	TonB-dependent receptor
CW731_04820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CW731_04825	COG2814	Major facilitator Superfamily
CW731_04830	COG1234	tRNA 3'-trailer cleavage
CW731_04870	COG0697	spore germination
CW731_04880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW731_04885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CW731_04895	COG0668	transmembrane transport
CW731_04905	COG3012	SEC-C Motif Domain Protein
CW731_04920	COG3842	ATPase activity
CW731_04940	COG1446	asparaginase
CW731_04945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CW731_04950	COG3142	Participates in the control of copper homeostasis
CW731_04955	COG0463	Glycosyl transferase, family 2
CW731_04955	COG1216	Glycosyl transferase, family 2
CW731_04960	COG0497	DNA recombination
CW731_04985	COG1528	Iron-storage protein
CW731_04990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW731_05015	COG1131	(ABC) transporter
CW731_05020	COG1363	Peptidase, m42
CW731_05035	COG2176	DNA-directed DNA polymerase activity
CW731_05045	COG1132	(ABC) transporter
CW731_05060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW731_05070	COG2204	response regulator
CW731_05075	COG3852	Histidine kinase
CW731_05090	COG1253	flavin adenine dinucleotide binding
CW731_05105	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CW731_05110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CW731_05115	COG1702	phosphate starvation-inducible protein PhoH
CW731_05120	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CW731_05130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CW731_05155	COG0038	chloride channel
CW731_05210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CW731_05215	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CW731_05220	COG0504	CTP synthase activity
CW731_05225	COG0706	membrane insertase activity
CW731_05230	COG1104	cysteine desulfurase activity
CW731_05245	COG2326	polyphosphate kinase activity
CW731_05280	COG0714	Associated with various cellular activities
CW731_05285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW731_05295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW731_05310	COG0514	ATP-dependent DNA helicase (RecQ)
CW731_05315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CW731_05320	COG0776	regulation of translation
CW731_05325	COG1678	Uncharacterized ACR, COG1678
CW731_05345	COG4974	Belongs to the 'phage' integrase family
CW731_05485	COG3586	endonuclease activity
CW731_05490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CW731_05495	COG1061	Type III restriction enzyme res subunit
CW731_05500	COG1002	Type II restriction enzyme, methylase subunits
CW731_05675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CW731_05830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW731_05865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CW731_05870	COG0228	four-way junction DNA binding
CW731_05915	COG1131	(ABC) transporter
CW731_05945	COG1428	Deoxynucleoside kinase
CW731_05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW731_05960	COG0154	amidase activity
CW731_05970	COG0552	protein localization to endoplasmic reticulum
CW731_05980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CW731_05985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CW731_05990	COG1058	Belongs to the CinA family
CW731_05990	COG1546	Belongs to the CinA family
CW731_06010	COG2996	Protein conserved in bacteria
CW731_06015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CW731_06020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CW731_06025	COG0300	oxidoreductase activity
CW731_06040	COG0463	Glycosyl transferase, family 2
CW731_06045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW731_06050	COG1132	(ABC) transporter
CW731_06065	COG0438	transferase activity, transferring glycosyl groups
CW731_06075	COG0438	transferase activity, transferring glycosyl groups
CW731_06080	COG0463	Glycosyl transferase, family 2
CW731_06090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CW731_06095	COG0242	peptide deformylase activity
CW731_06105	COG3956	TIGRFAM MazG family protein
CW731_06115	COG3263	regulation of cellular component size
CW731_06120	COG1213	nucleotidyl transferase
CW731_06125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CW731_06140	COG0592	DNA-directed DNA polymerase activity
CW731_06145	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CW731_06150	COG0405	Gamma-glutamyltransferase
CW731_06160	COG0564	pseudouridine synthase activity
CW731_06170	COG0628	permease
CW731_06180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CW731_06195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW731_06200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW731_06200	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CW731_06240	COG1192	Involved in chromosome partitioning
CW731_06275	COG0732	type I restriction modification DNA specificity domain
CW731_06335	COG0183	Belongs to the thiolase family
CW731_06340	COG0791	NLP P60 protein
CW731_06355	COG0542	response to heat
CW731_06370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW731_06375	COG0825	malonyl-CoA metabolic process
CW731_06390	COG0343	queuine tRNA-ribosyltransferase activity
CW731_06395	COG1187	pseudouridine synthase activity
CW731_06405	COG0006	proline dipeptidase activity
CW731_06410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW731_06415	COG3938	Belongs to the proline racemase family
CW731_06425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW731_06445	COG2217	Heavy metal translocating P-type atpase
CW731_06485	COG4206	TonB-dependent receptor
CW731_06485	COG1629	transport
CW731_06500	COG3279	Response regulator of the LytR AlgR family
CW731_06510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CW731_06530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CW731_06535	COG0085	RNA polymerase activity
CW731_06540	COG0222	ribosome binding
CW731_06545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CW731_06550	COG0081	regulation of translation
CW731_06555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CW731_06605	COG4974	Belongs to the 'phage' integrase family
CW731_06610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CW731_06615	COG1960	acyl-CoA dehydrogenase activity
CW731_06625	COG1115	amino acid carrier protein
CW731_06630	COG1115	amino acid carrier protein
CW731_06655	COG1611	Belongs to the LOG family
CW731_06700	COG2195	Cleaves the N-terminal amino acid of tripeptides
CW731_06705	COG1192	Involved in chromosome partitioning
CW731_06710	COG1475	DNA binding
CW731_06720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CW731_06725	COG0681	Belongs to the peptidase S26 family
CW731_06800	COG1472	Belongs to the glycosyl hydrolase 3 family
CW731_06815	COG2326	polyphosphate kinase activity
CW731_06820	COG2032	superoxide dismutase activity
CW731_06830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW731_06915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CW731_06920	COG0540	Belongs to the ATCase OTCase family
CW731_06935	COG1234	tRNA 3'-trailer cleavage
CW731_06960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW731_06970	COG0326	Molecular chaperone. Has ATPase activity
CW731_06975	COG2321	neutral zinc metallopeptidase
CW731_07000	COG0564	pseudouridine synthase activity
CW731_07010	COG1181	Belongs to the D-alanine--D-alanine ligase family
CW731_07015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CW731_07025	COG2706	6-phosphogluconolactonase activity
CW731_07035	COG2010	Cytochrome c
CW731_07035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CW731_07050	COG0494	nUDIX hydrolase
CW731_07055	COG1061	Type III restriction enzyme res subunit
CW731_07065	COG0659	secondary active sulfate transmembrane transporter activity
CW731_07075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CW731_07090	COG0799	negative regulation of ribosome biogenesis
CW731_07095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW731_07105	COG4589	Belongs to the CDS family
CW731_07110	COG0688	phosphatidylethanolamine metabolic process
CW731_07125	COG1090	epimerase
CW731_07155	COG1595	DNA-templated transcription, initiation
CW731_07170	COG3022	response to hydroperoxide
CW731_07175	COG2949	membrane
CW731_07180	COG1760	l-serine dehydratase
CW731_07190	COG0443	Heat shock 70 kDa protein
CW731_07200	COG3275	phosphorelay sensor kinase activity
CW731_07205	COG3279	Response regulator of the LytR AlgR family
CW731_07215	COG3275	phosphorelay sensor kinase activity
CW731_07220	COG3275	phosphorelay sensor kinase activity
CW731_07225	COG3279	Response regulator of the LytR AlgR family
CW731_07240	COG1252	NADH dehydrogenase
CW731_07295	COG1917	Cupin 2, conserved barrel domain protein
CW731_07300	COG1028	Short-chain dehydrogenase reductase Sdr
CW731_07325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW731_07330	COG3844	kynureninase activity
CW731_07335	COG0791	NLP P60 protein
CW731_07340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CW731_07350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW731_07350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW731_07355	COG1047	Peptidyl-prolyl cis-trans
CW731_07375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CW731_07395	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW731_07415	COG0408	coproporphyrinogen oxidase activity
CW731_07430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CW731_07440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CW731_07445	COG0113	porphobilinogen synthase activity
CW731_07450	COG0181	hydroxymethylbilane synthase activity
CW731_07455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CW731_07470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CW731_07480	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CW731_07485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW731_07490	COG2076	Multidrug Resistance protein
CW731_07500	COG1522	sequence-specific DNA binding
CW731_07510	COG0259	pyridoxamine-phosphate oxidase activity
CW731_07520	COG0248	Ppx GppA phosphatase
CW731_07530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW731_07535	COG1663	tetraacyldisaccharide 4'-kinase activity
CW731_07540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CW731_07550	COG1196	nuclear chromosome segregation
CW731_07590	COG0450	alkyl hydroperoxide reductase
CW731_07595	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CW731_07605	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CW731_07605	COG3264	Mechanosensitive ion channel
CW731_07610	COG1668	transmembrane transport
CW731_07615	COG4152	abc transporter atp-binding protein
CW731_07625	COG1024	Enoyl-CoA hydratase
CW731_07625	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW731_07630	COG0183	Belongs to the thiolase family
CW731_07635	COG1960	acyl-CoA dehydrogenase activity
CW731_07655	COG0492	ferredoxin-NADP+ reductase activity
CW731_07680	COG1629	transport
CW731_07680	COG4206	TonB-dependent receptor
CW731_07695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW731_07715	COG0702	epimerase
CW731_07725	COG0415	Belongs to the DNA photolyase family
CW731_07730	COG3046	protein related to deoxyribodipyrimidine photolyase
CW731_07735	COG0415	Belongs to the DNA photolyase family
CW731_07750	COG0302	gtp cyclohydrolase
CW731_07765	COG1028	Short-chain dehydrogenase reductase Sdr
CW731_07770	COG0386	Belongs to the glutathione peroxidase family
CW731_07785	COG0415	Belongs to the DNA photolyase family
CW731_07795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW731_07800	COG0572	uridine kinase
CW731_07820	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW731_07820	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW731_07840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CW731_07840	COG1333	cytochrome c biogenesis protein
CW731_07855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CW731_07855	COG0519	Catalyzes the synthesis of GMP from XMP
CW731_07860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW731_07870	COG0295	cytidine deaminase activity
CW731_07885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW731_07900	COG4464	protein tyrosine phosphatase activity
CW731_07920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW731_07930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW731_07935	COG1216	Glycosyl transferase, family 2
CW731_07960	COG0562	UDP-galactopyranose mutase
CW731_07965	COG2244	polysaccharide biosynthetic process
CW731_07980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CW731_07980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CW731_08005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CW731_08010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW731_08040	COG0285	dihydrofolate synthase activity
CW731_08050	COG0848	biopolymer transport protein
CW731_08055	COG0811	peptide transport
CW731_08060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CW731_08075	COG1960	acyl-CoA dehydrogenase activity
CW731_08095	COG0004	ammonium transporteR
CW731_08100	COG0069	glutamate synthase activity
CW731_08100	COG0067	glutamate synthase
CW731_08100	COG0070	glutamate synthase
CW731_08105	COG0493	'glutamate synthase
CW731_08135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CW731_08140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CW731_08145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CW731_08150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CW731_08160	COG0297	glycogen (starch) synthase activity
CW731_08170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CW731_08180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CW731_08195	COG1522	sequence-specific DNA binding
CW731_08225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CW731_08235	COG0174	glutamine synthetase
CW731_08270	COG2264	protein methyltransferase activity
CW731_08275	COG0149	triose-phosphate isomerase activity
CW731_08285	COG0284	orotidine-5'-phosphate decarboxylase activity
CW731_08290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CW731_08315	COG1703	isobutyryl-CoA mutase activity
CW731_08315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW731_08315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW731_08320	COG0626	cystathionine gamma-synthase activity
CW731_08360	COG1435	thymidine kinase activity
CW731_08365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CW731_08370	COG1970	mechanosensitive ion channel activity
CW731_08375	COG1022	Amp-dependent synthetase and ligase
CW731_08385	COG1960	acyl-CoA dehydrogenase activity
CW731_08390	COG1024	Enoyl-CoA hydratase
CW731_08390	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW731_08395	COG0183	Belongs to the thiolase family
CW731_08470	COG3279	Response regulator of the LytR AlgR family
CW731_08475	COG2972	Histidine kinase
CW731_08475	COG0745	RESPONSE REGULATOR receiver
CW731_08485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CW731_08495	COG1160	GTP binding
CW731_08510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW731_08515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW731_08520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CW731_08530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW731_08535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CW731_08550	COG2363	Small membrane protein
CW731_08560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CW731_08570	COG1704	LemA family
CW731_08580	COG4942	peptidase
CW731_08585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CW731_08610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CW731_08630	COG2226	methyltransferase
CW731_08645	COG1477	protein flavinylation
CW731_08655	COG0300	oxidoreductase activity
CW731_08665	COG0513	Belongs to the DEAD box helicase family
CW731_08670	COG0084	hydrolase, TatD family'
CW731_08700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CW731_08705	COG0191	fructose-bisphosphate aldolase activity
CW731_08715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW731_08725	COG2226	methyltransferase
CW731_08730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CW731_08745	COG0442	prolyl-tRNA aminoacylation
CW731_08755	COG0268	Binds directly to 16S ribosomal RNA
CW731_08760	COG0772	Belongs to the SEDS family
CW731_08765	COG0768	penicillin binding
CW731_08775	COG1792	Involved in formation and maintenance of cell shape
CW731_08780	COG1077	Cell shape determining protein MreB Mrl
CW731_08785	COG0138	bifunctional purine biosynthesis protein purh
CW731_08790	COG1956	GAF domain-containing protein
CW731_08830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CW731_08850	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CW731_08865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW731_08875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CW731_08890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW731_08890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW731_08900	COG2255	four-way junction helicase activity
CW731_08905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CW731_08935	COG0437	4 iron, 4 sulfur cluster binding
CW731_08940	COG3474	cytochrome
CW731_08955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CW731_08960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CW731_08965	COG0195	Participates in both transcription termination and antitermination
CW731_08970	COG0779	Required for maturation of 30S ribosomal subunits
CW731_08985	COG1012	belongs to the aldehyde dehydrogenase family
CW731_08990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CW731_08995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CW731_09000	COG0440	acetolactate synthase activity
CW731_09005	COG0028	Belongs to the TPP enzyme family
CW731_09010	COG0129	dihydroxy-acid dehydratase activity
CW731_09015	COG0473	3-isopropylmalate dehydrogenase activity
CW731_09020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CW731_09030	COG0527	aspartate kinase activity
CW731_09030	COG0460	homoserine dehydrogenase
CW731_09035	COG0083	homoserine kinase activity
CW731_09040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CW731_09055	COG1609	Transcriptional regulator
CW731_09075	COG0363	glucosamine-6-phosphate deaminase activity
CW731_09080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CW731_09105	COG0726	polysaccharide deacetylase
CW731_09125	COG1408	metallophosphoesterase
CW731_09145	COG3023	N-Acetylmuramoyl-L-alanine amidase
CW731_09155	COG0009	L-threonylcarbamoyladenylate synthase
CW731_09160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CW731_09165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CW731_09170	COG0052	Belongs to the universal ribosomal protein uS2 family
CW731_09175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CW731_09180	COG0528	UMP kinase activity
CW731_09185	COG0233	cytoplasmic translational termination
CW731_09195	COG0017	Asparaginyl-tRNA synthetase
CW731_09200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CW731_09220	COG0848	biopolymer transport protein
CW731_09230	COG0811	peptide transport
CW731_09235	COG0252	asparaginase activity
CW731_09245	COG0481	GTPase activity
CW731_09260	COG4591	ABC-type transport system involved in lipoprotein release permease component
CW731_09265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CW731_09275	COG4585	Histidine kinase
CW731_09290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CW731_09295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CW731_09310	COG1074	ATP-dependent DNA helicase activity
CW731_09325	COG4771	TonB-dependent receptor
CW731_09340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CW731_09355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW731_09355	COG0758	DNA mediated transformation
CW731_09370	COG0668	transmembrane transport
CW731_09375	COG0693	protein deglycase activity
CW731_09395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CW731_09410	COG1785	Belongs to the alkaline phosphatase family
CW731_09430	COG2365	Tyrosine phosphatase family
CW731_09435	COG0488	(ABC) transporter
CW731_09450	COG0745	RESPONSE REGULATOR receiver
CW731_09455	COG5002	protein histidine kinase activity
CW731_09465	COG0151	Belongs to the GarS family
CW731_09545	COG0594	ribonuclease P activity
CW731_09560	COG2207	Transcriptional regulator
CW731_09560	COG1917	Cupin 2, conserved barrel domain protein
CW731_09565	COG1629	transport
CW731_09565	COG4206	TonB-dependent receptor
CW731_09575	COG1785	Belongs to the alkaline phosphatase family
CW731_09580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW731_09620	COG1294	oxidase, subunit
CW731_09625	COG1271	oxidase subunit
CW731_09645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CW731_09650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CW731_09690	COG1946	Acyl-CoA thioesterase
CW731_09695	COG5658	integral membrane protein
CW731_09700	COG4206	TonB-dependent receptor
CW731_09705	COG1381	Involved in DNA repair and RecF pathway recombination
CW731_09720	COG1272	protein, Hemolysin III
CW731_09730	COG0180	Tryptophanyl-tRNA synthetase
CW731_09740	COG0741	lytic transglycosylase activity
CW731_09740	COG1388	LysM domain
CW731_09745	COG0708	Exodeoxyribonuclease III
CW731_09765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CW731_09780	COG1774	PSP1 C-terminal conserved region
CW731_09790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CW731_09795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CW731_09815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW731_09820	COG4953	penicillin-binding protein 1C
CW731_09825	COG2373	Large extracellular alpha-helical protein
CW731_09840	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CW731_09845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW731_09855	COG0667	Aldo Keto reductase
CW731_09860	COG0126	phosphoglycerate kinase activity
CW731_09865	COG0470	DNA polymerase III
CW731_09880	COG0534	Mate efflux family protein
CW731_09920	COG1629	transport
CW731_09920	COG4206	TonB-dependent receptor
CW731_09925	COG0166	Belongs to the GPI family
CW731_09940	COG3483	tryptophan 2,3-dioxygenase activity
CW731_09945	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CW731_09950	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CW731_09965	COG0492	ferredoxin-NADP+ reductase activity
CW731_09970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CW731_09970	COG0316	Belongs to the HesB IscA family
CW731_09975	COG0489	protein tyrosine kinase activity
CW731_09995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CW731_10010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CW731_10015	COG1652	LysM domain
CW731_10025	COG1561	YicC-like family, N-terminal region
CW731_10030	COG0194	GDP metabolic process
CW731_10035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CW731_10040	COG0739	heme binding
CW731_10050	COG0720	synthase
CW731_10055	COG0193	aminoacyl-tRNA hydrolase activity
CW731_10060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CW731_10065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CW731_10075	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW731_10080	COG1085	galactose-1-phosphate uridylyltransferase
CW731_10085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CW731_10095	COG1725	Transcriptional regulator
CW731_10110	COG0793	Belongs to the peptidase S41A family
CW731_10115	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW731_10145	COG0714	Associated with various cellular activities
CW731_10165	COG2304	oxidoreductase activity
CW731_10190	COG0659	secondary active sulfate transmembrane transporter activity
CW731_10195	COG0288	reversible hydration of carbon dioxide
CW731_10215	COG1028	Short-chain dehydrogenase reductase Sdr
CW731_10225	COG0792	nuclease activity
CW731_10230	COG1619	proteins homologs of microcin C7 resistance protein MccF
CW731_10240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW731_10240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW731_10275	COG2201	protein-glutamate methylesterase activity
CW731_10280	COG4251	negative regulation of phosphorylation
CW731_10310	COG4221	oxidoreductase activity
CW731_10325	COG0629	single-stranded DNA binding
CW731_10355	COG0571	ribonuclease III activity
CW731_10360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW731_10365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW731_10370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CW731_10375	COG0328	RNA-DNA hybrid ribonuclease activity
CW731_10375	COG3341	Caulimovirus viroplasmin
CW731_10395	COG3620	sequence-specific DNA binding
CW731_10440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW731_10460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CW731_10465	COG1053	succinate dehydrogenase
CW731_10485	COG0513	Belongs to the DEAD box helicase family
CW731_10490	COG0006	proline dipeptidase activity
CW731_10495	COG1858	cytochrome C peroxidase
CW731_10525	COG1959	2 iron, 2 sulfur cluster binding
CW731_10555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW731_10580	COG1114	Component of the transport system for branched-chain amino acids
CW731_10600	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CW731_10605	COG1858	cytochrome C peroxidase
CW731_10615	COG0719	Fe-S assembly protein
CW731_10625	COG0396	ATPase activity
CW731_10630	COG0719	Fe-S assembly protein
CW731_10645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CW731_10660	COG0196	riboflavin kinase activity
CW731_10665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CW731_10685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CW731_10690	COG2239	Acts as a magnesium transporter
CW731_10710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW731_10745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW731_10760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW731_10775	COG1595	DNA-templated transcription, initiation
CW731_10780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CW731_10785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW731_10810	COG2226	methyltransferase
CW731_10815	COG0445	tRNA wobble uridine modification
CW731_10820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CW731_10830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW731_10830	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CW731_10850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW731_10860	COG0393	Putative heavy-metal-binding
CW731_10865	COG0557	exoribonuclease II activity
CW731_10870	COG1597	lipid kinase activity
CW731_10880	COG2153	protein acetylation
CW731_10915	COG1187	pseudouridine synthase activity
CW731_10925	COG3645	SOS response
CW731_10930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CW731_10945	COG0756	dUTP diphosphatase activity
CW731_10950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW731_10975	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CW731_10990	COG1757	Na H antiporter
CW731_11000	COG1309	transcriptional regulator
CW731_11005	COG1538	Outer membrane efflux protein
CW731_11015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW731_11030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CW731_11035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW731_11070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW731_11085	COG0445	tRNA wobble uridine modification
CW731_11095	COG3424	synthase
CW731_11100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW731_11105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW731_11110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW731_11135	COG3590	peptidase
CW731_11140	COG2072	flavoprotein involved in K transport
CW731_11145	COG1505	serine-type exopeptidase activity
CW731_11180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CW731_11205	COG0356	it plays a direct role in the translocation of protons across the membrane
CW731_11210	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW731_11215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CW731_11220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW731_11225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CW731_11230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CW731_11240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW731_11245	COG1012	belongs to the aldehyde dehydrogenase family
CW731_11250	COG1446	asparaginase
CW731_11290	COG1970	mechanosensitive ion channel activity
CW731_11295	COG1733	regulation of RNA biosynthetic process
CW731_11300	COG0778	Nitroreductase
CW731_11355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CW731_11370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CW731_11380	COG0463	Glycosyl transferase, family 2
CW731_11395	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CW731_11400	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CW731_11410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CW731_11415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CW731_11430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CW731_11440	COG2095	MarC family integral membrane protein
CW731_11470	COG0109	protoheme IX farnesyltransferase activity
CW731_11475	COG1845	cytochrome c oxidase, subunit III
CW731_11495	COG1999	signal sequence binding
CW731_11500	COG2322	membrane
CW731_11515	COG1214	PFAM Peptidase M22, glycoprotease
CW731_11520	COG0668	transmembrane transport
CW731_11545	COG0509	glycine decarboxylation via glycine cleavage system
CW731_11555	COG0632	four-way junction helicase activity
CW731_11580	COG0314	molybdopterin synthase activity
CW731_11590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CW731_11590	COG1328	CTP reductase activity
CW731_11595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW731_11605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CW731_11615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CW731_11625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CW731_11640	COG3655	Transcriptional regulator
CW731_11655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CW731_11670	COG4206	TonB-dependent receptor
CW731_11675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CW731_11685	COG2268	Band 7 protein
CW731_11700	COG1999	signal sequence binding
CW731_11725	COG0495	leucyl-tRNA aminoacylation
CW731_11730	COG5000	phosphorelay sensor kinase activity
CW731_11735	COG1024	Enoyl-CoA hydratase
CW731_11745	COG2207	Transcriptional regulator
CW731_11750	COG1418	mRNA catabolic process
CW731_11775	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CW731_11805	COG2885	chlorophyll binding
CW731_11810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CW731_11825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CW731_11880	COG4585	Histidine kinase
CW731_11895	COG0322	excinuclease ABC activity
CW731_11935	COG0612	Peptidase, M16
CW731_11940	COG0612	Peptidase, M16
CW731_11945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CW731_11950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CW731_11955	COG3275	phosphorelay sensor kinase activity
CW731_11960	COG2201	protein-glutamate methylesterase activity
CW731_11965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CW731_11965	COG1519	Transferase
CW731_11980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CW731_11985	COG0303	'Molybdopterin
CW731_11995	COG0746	molybdenum cofactor guanylyltransferase activity
CW731_11995	COG0315	cyclic pyranopterin monophosphate synthase activity
CW731_12000	COG0746	molybdenum cofactor guanylyltransferase activity
CW731_12005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CW731_12025	COG0629	single-stranded DNA binding
CW731_12030	COG1194	a g-specific adenine glycosylase
CW731_12035	COG0776	regulation of translation
CW731_12040	COG1530	ribonuclease E activity
CW731_12120	COG0346	lactoylglutathione lyase activity
CW731_12125	COG2177	Part of the ABC transporter FtsEX involved in
CW731_12135	COG1968	undecaprenyl-diphosphatase activity
CW731_12140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CW731_12150	COG0583	DNA-binding transcription factor activity
CW731_12160	COG0564	pseudouridine synthase activity
CW731_12185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW731_12200	COG2137	regulation of response to DNA damage stimulus
CW731_12220	COG1309	transcriptional regulator
CW731_12235	COG1331	Highly conserved protein containing a thioredoxin domain
CW731_12265	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CW731_12275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CW731_12280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW731_12285	COG0511	ligase activity, forming carbon-carbon bonds
CW731_12290	COG0439	Biotin carboxylase
CW731_12295	COG1522	sequence-specific DNA binding
CW731_12305	COG3279	Response regulator of the LytR AlgR family
CW731_12330	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW731_12340	COG0300	oxidoreductase activity
CW731_12345	COG1012	belongs to the aldehyde dehydrogenase family
CW731_12350	COG2755	lipolytic protein G-D-S-L family
CW731_12350	COG0657	acetylesterase activity
CW731_12355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW731_12360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CW731_12360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CW731_12370	COG1629	transport
CW731_12370	COG4206	TonB-dependent receptor
CW731_12385	COG0156	8-amino-7-oxononanoate synthase activity
CW731_12390	COG4948	Mandelate Racemase Muconate Lactonizing
CW731_12410	COG1573	uracil-dna glycosylase
CW731_12425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CW731_12435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CW731_12450	COG0584	glycerophosphoryl diester phosphodiesterase
CW731_12465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CW731_12470	COG1253	flavin adenine dinucleotide binding
CW731_12490	COG2151	metal-sulfur cluster biosynthetic enzyme
CW731_12495	COG2166	iron-sulfur cluster assembly
CW731_12500	COG0351	phosphomethylpyrimidine kinase
CW731_12520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CW731_12530	COG0460	homoserine dehydrogenase
CW731_12530	COG0527	aspartate kinase activity
CW731_12540	COG1950	PFAM Membrane protein of
CW731_12545	COG0544	peptidyl-prolyl cis-trans isomerase activity
CW731_12555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CW731_12560	COG0358	DNA primase activity
CW731_12565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CW731_12580	COG2885	chlorophyll binding
CW731_12585	COG1428	Deoxynucleoside kinase
CW731_12590	COG1185	polyribonucleotide nucleotidyltransferase activity
CW731_12595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CW731_12600	COG1605	Chorismate mutase
CW731_12600	COG0077	Prephenate dehydratase
CW731_12605	COG0436	Aminotransferase
CW731_12610	COG0287	Prephenate dehydrogenase
CW731_12615	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CW731_12620	COG1162	GTPase activity
CW731_12625	COG1490	D-aminoacyl-tRNA deacylase activity
CW731_12630	COG0084	hydrolase, TatD family'
CW731_12635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CW731_12650	COG1522	sequence-specific DNA binding
CW731_12660	COG2095	MarC family integral membrane protein
CW731_12695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CW731_12705	COG0321	lipoyl(octanoyl) transferase activity
CW731_12715	COG1012	belongs to the aldehyde dehydrogenase family
CW731_12750	COG2204	response regulator
CW731_12755	COG2205	protein histidine kinase activity
CW731_12755	COG0784	Response regulator, receiver
CW731_12770	COG1805	sodium ion transport
CW731_12775	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW731_12780	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW731_12785	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW731_12795	COG1073	alpha beta
CW731_12805	COG0745	RESPONSE REGULATOR receiver
CW731_12825	COG1610	YqeY-like protein
CW731_12845	COG3275	phosphorelay sensor kinase activity
CW731_12850	COG3279	Response regulator of the LytR AlgR family
CW731_12855	COG1199	ATP-dependent helicase activity
CW731_12855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CW731_12860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CW731_12865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CW731_12870	COG1191	sigma factor activity
CW731_12880	COG1040	competence protein
CW731_12885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CW731_12890	COG0423	glycine-tRNA ligase activity
CW731_12900	COG0459	protein refolding
CW731_12905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CW731_12925	COG3604	Transcriptional regulator
CW731_12930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW731_12955	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW731_12985	COG0488	(ABC) transporter
CW731_12990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CW731_12995	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW731_13000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CW731_13020	COG4206	TonB-dependent receptor
CW731_13020	COG1629	transport
CW731_13050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CW731_13060	COG0527	aspartate kinase activity
CW731_13060	COG0460	homoserine dehydrogenase
CW731_13070	COG1959	2 iron, 2 sulfur cluster binding
CW731_13080	COG0175	sulfate reduction
CW731_13085	COG0175	sulfate reduction
CW731_13095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CW731_13100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW731_13105	COG1648	precorrin-2 dehydrogenase activity
CW731_13105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW731_13110	COG1648	precorrin-2 dehydrogenase activity
CW731_13110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW731_13115	COG0492	ferredoxin-NADP+ reductase activity
CW731_13120	COG0633	Ferredoxin
CW731_13125	COG1045	serine acetyltransferase
CW731_13135	COG0646	methionine synthase
CW731_13135	COG1410	methionine synthase
CW731_13145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CW731_13150	COG3118	belongs to the thioredoxin family
CW731_13185	COG3250	beta-galactosidase activity
CW731_13195	COG3279	Response regulator of the LytR AlgR family
CW731_13200	COG2201	protein-glutamate methylesterase activity
CW731_13210	COG0673	inositol 2-dehydrogenase activity
CW731_13215	COG1629	transport
CW731_13215	COG4206	TonB-dependent receptor
CW731_13235	COG0606	chelatase, subunit chli
CW731_13260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CW731_13280	COG0037	tRNA processing
CW731_13290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CW731_13295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW731_13310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW731_13325	COG1649	PFAM Uncharacterised BCR, COG1649
CW731_13330	COG1349	DNA-binding transcription factor activity
CW731_13335	COG4206	TonB-dependent receptor
CW731_13335	COG1629	transport
CW731_13350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CW731_13360	COG1472	Belongs to the glycosyl hydrolase 3 family
CW731_13365	COG3876	Protein conserved in bacteria
CW731_13370	COG0339	signal peptide processing
CW731_13380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CW731_13385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CW731_13395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CW731_13405	COG4191	Histidine kinase
CW731_13430	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CW731_13450	COG2217	Heavy metal translocating P-type atpase
CW731_13455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW731_13465	COG3278	Belongs to the heme-copper respiratory oxidase family
CW731_13500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CW731_13520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CW731_13530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CW731_13540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CW731_13545	COG0596	Alpha beta hydrolase
CW731_13550	COG0671	phosphoesterase, PA-phosphatase related
CW731_13585	COG1187	pseudouridine synthase activity
CW731_13590	COG0010	Belongs to the arginase family
CW731_13595	COG1228	amidohydrolase
CW731_13600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CW731_13605	COG2986	histidine ammonia-lyase
CW731_13610	COG0583	DNA-binding transcription factor activity
CW731_13620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CW731_13645	COG1253	flavin adenine dinucleotide binding
CW731_13665	COG2197	response regulator
CW731_13690	COG1132	(ABC) transporter
CW731_13705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CW731_13730	COG0038	chloride channel
CW731_13745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW731_13755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CW731_13755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW731_13770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CW731_13775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW731_13785	COG0598	Magnesium transport protein CorA
CW731_13800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CW731_13805	COG4206	TonB-dependent receptor
CW731_13805	COG1629	transport
CW731_13815	COG3250	beta-galactosidase activity
CW731_13820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CW731_13825	COG3408	Glycogen debranching enzyme
CW731_13825	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CW731_13835	COG1629	transport
CW731_13835	COG4206	TonB-dependent receptor
CW731_13845	COG1748	Saccharopine dehydrogenase
CW731_13850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CW731_13855	COG0564	pseudouridine synthase activity
CW731_13860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CW731_13870	COG2001	Belongs to the MraZ family
CW731_13875	COG0275	rRNA processing
CW731_13885	COG0768	penicillin binding
CW731_13890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CW731_13895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CW731_13900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CW731_13905	COG0772	Belongs to the SEDS family
CW731_13910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CW731_13915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW731_13930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CW731_13970	COG1482	cell wall glycoprotein biosynthetic process
CW731_13980	COG0793	Belongs to the peptidase S41A family
CW731_13985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CW731_13995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW731_14000	COG0791	NLP P60 protein
CW731_14010	COG4232	protein-disulfide reductase activity
CW731_14015	COG3104	oligopeptide transport
CW731_14020	COG0823	Involved in the tonB-independent uptake of proteins
CW731_14020	COG1506	peptidase
CW731_14035	COG2081	HI0933 family
CW731_14080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CW731_14085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CW731_14090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CW731_14110	COG0561	phosphatase activity
CW731_14115	COG1609	Transcriptional regulator
CW731_14125	COG1215	transferase activity, transferring glycosyl groups
CW731_14130	COG0463	Glycosyl transferase, family 2
CW731_14165	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CW731_14215	COG2226	methyltransferase
CW731_14235	COG4206	TonB-dependent receptor
CW731_14235	COG1629	transport
CW731_14260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CW731_14270	COG0612	Peptidase, M16
CW731_14295	COG2824	Alkylphosphonate utilization operon protein PhnA
CW731_14315	COG3239	Fatty acid desaturase
CW731_14320	COG0357	Ribosomal RNA small subunit methyltransferase G
CW731_14330	COG2066	Belongs to the glutaminase family
CW731_14335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CW731_14375	COG1629	transport
CW731_14375	COG4206	TonB-dependent receptor
CW731_14400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CW731_14405	COG0563	adenylate kinase activity
CW731_14410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CW731_14420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CW731_14425	COG0514	ATP-dependent DNA helicase (RecQ)
CW731_14440	COG0187	DNA topoisomerase II activity
CW731_14445	COG4771	TonB-dependent receptor
CW731_14450	COG0584	glycerophosphoryl diester phosphodiesterase
CW731_14460	COG0154	amidase activity
CW731_14465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CW731_14475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW731_14480	COG0512	Glutamine amidotransferase of anthranilate synthase
CW731_14485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CW731_14490	COG0134	indole-3-glycerol-phosphate synthase activity
CW731_14495	COG0135	phosphoribosylanthranilate isomerase activity
CW731_14500	COG0133	tryptophan synthase activity
CW731_14510	COG0159	tryptophan synthase activity
CW731_14515	COG0545	Peptidyl-prolyl cis-trans isomerase
CW731_14520	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CW731_14545	COG2884	Cell division ATP-binding protein ftsE
CW731_14575	COG3530	Putative quorum-sensing-regulated virulence factor
CW731_14595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CW731_14600	COG2234	aminopeptidase activity
CW731_14640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CW731_14645	COG0569	domain protein
CW731_14650	COG2003	Belongs to the UPF0758 family
CW731_14695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CW731_14705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW731_14720	COG1629	transport
CW731_14720	COG4206	TonB-dependent receptor
CW731_14760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CW731_14765	COG0049	tRNA binding
CW731_14770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CW731_14775	COG0051	transcription antitermination factor activity, RNA binding
CW731_14780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CW731_14785	COG0088	Forms part of the polypeptide exit tunnel
CW731_14790	COG0089	rRNA binding
CW731_14795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CW731_14800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CW731_14805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CW731_14810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CW731_14815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CW731_14820	COG0255	Belongs to the universal ribosomal protein uL29 family
CW731_14825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CW731_14830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CW731_14835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CW731_14840	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CW731_14845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CW731_14850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CW731_14855	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CW731_14865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CW731_14870	COG1841	ribosomal large subunit assembly
CW731_14875	COG0200	Binds to the 23S rRNA
CW731_14885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CW731_14890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CW731_14895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CW731_14900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CW731_14905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CW731_14910	COG0202	RNA polymerase activity
CW731_14915	COG0203	ribosomal protein L17
CW731_14920	COG0505	Belongs to the CarA family
CW731_14925	COG0148	phosphopyruvate hydratase activity
CW731_14950	COG2339	peptidase activity
CW731_14965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW731_14970	COG1127	ABC transporter
CW731_15005	COG0402	S-adenosylhomocysteine deaminase activity
CW731_15025	COG0254	rRNA binding
CW731_15030	COG0069	glutamate synthase activity
CW731_15035	COG0492	ferredoxin-NADP+ reductase activity
CW731_15045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW731_15065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CW731_15075	COG0205	6-phosphofructokinase activity
CW731_15085	COG0251	oxidation-reduction process
CW731_15095	COG0860	N-Acetylmuramoyl-L-alanine amidase
CW731_15105	COG0247	lactate metabolic process
CW731_15105	COG2181	nitrate reductase activity
CW731_15110	COG0247	lactate metabolic process
CW731_15110	COG2181	nitrate reductase activity
CW731_15130	COG1575	Belongs to the MenA family. Type 1 subfamily
CW731_15140	COG4948	Mandelate Racemase Muconate Lactonizing
CW731_15160	COG0217	transcriptional regulatory protein
CW731_15170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CW731_15175	COG0857	belongs to the CobB CobQ family
CW731_15175	COG0280	phosphate acetyltransferase
CW731_15180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CW731_15190	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CW731_15215	COG0494	nUDIX hydrolase
CW731_15260	COG1741	Belongs to the pirin family
CW731_15265	COG1012	belongs to the aldehyde dehydrogenase family
CW731_15270	COG0446	pyridine nucleotide-disulphide oxidoreductase
CW731_15270	COG1902	pentaerythritol trinitrate reductase activity
CW731_15285	COG0488	(ABC) transporter
CW731_15300	COG4585	Histidine kinase
CW731_15360	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CW731_15380	COG0577	efflux transmembrane transporter activity
CW731_15380	COG1136	(ABC) transporter
CW731_15395	COG0335	large ribosomal subunit rRNA binding
CW731_15415	COG0336	Belongs to the RNA methyltransferase TrmD family
CW731_15430	COG0189	ligase activity
CW731_15435	COG4067	protein conserved in archaea
CW731_15435	COG0189	ligase activity
CW731_15440	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CW731_15445	COG2423	ornithine cyclodeaminase activity
CW731_15450	COG2890	protein-(glutamine-N5) methyltransferase activity
CW731_15455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW731_15470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW731_15470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW731_15475	COG1011	Hydrolase
CW731_15480	COG0697	spore germination
CW731_15485	COG1739	Uncharacterized protein family UPF0029