locus-tag	class	description
CS374_00005	COG0525	valine-tRNA ligase activity
CS374_00020	COG0492	ferredoxin-NADP+ reductase activity
CS374_00030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CS374_00060	COG0438	transferase activity, transferring glycosyl groups
CS374_00085	COG1022	Amp-dependent synthetase and ligase
CS374_00105	COG1979	alcohol dehydrogenase
CS374_00125	COG1187	pseudouridine synthase activity
CS374_00130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CS374_00140	COG1492	cobalamin metabolic process
CS374_00145	COG2096	Adenosyltransferase
CS374_00160	COG0560	Phosphoserine phosphatase
CS374_00165	COG0247	lactate metabolic process
CS374_00170	COG1139	Iron-sulfur cluster binding protein
CS374_00175	COG1556	Lactate utilization protein
CS374_00185	COG2885	chlorophyll binding
CS374_00185	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CS374_00190	COG0602	queuosine metabolic process
CS374_00195	COG0720	synthase
CS374_00210	COG0789	Transcriptional regulator
CS374_00230	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS374_00255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS374_00270	COG1438	arginine binding
CS374_00275	COG2194	sulfuric ester hydrolase activity
CS374_00290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CS374_00305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CS374_00325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CS374_00335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CS374_00340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS374_00365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CS374_00365	COG0574	Belongs to the PEP-utilizing enzyme family
CS374_00375	COG0427	acetyl-CoA hydrolase
CS374_00380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS374_00385	COG1131	(ABC) transporter
CS374_00400	COG1725	Transcriptional regulator
CS374_00455	COG1090	epimerase
CS374_00465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CS374_00470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CS374_00475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CS374_00480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CS374_00515	COG0729	surface antigen
CS374_00520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CS374_00525	COG2226	methyltransferase
CS374_00530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CS374_00535	COG1702	phosphate starvation-inducible protein PhoH
CS374_00585	COG0688	phosphatidylethanolamine metabolic process
CS374_00600	COG0442	prolyl-tRNA aminoacylation
CS374_00610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CS374_00615	COG0489	protein tyrosine kinase activity
CS374_00625	COG1959	2 iron, 2 sulfur cluster binding
CS374_00625	COG1295	ribonuclease BN
CS374_00630	COG0196	riboflavin kinase activity
CS374_00650	COG0756	dUTP diphosphatase activity
CS374_00655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CS374_00660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CS374_00665	COG0509	glycine decarboxylation via glycine cleavage system
CS374_00685	COG4152	abc transporter atp-binding protein
CS374_00690	COG1668	transmembrane transport
CS374_00715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CS374_00725	COG2252	PERMEase
CS374_00730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CS374_00735	COG1032	radical SAM domain protein
CS374_00740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CS374_00765	COG2204	response regulator
CS374_00770	COG0802	atpase or kinase
CS374_00780	COG1435	thymidine kinase activity
CS374_00785	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CS374_00790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CS374_00795	COG4591	ABC-type transport system involved in lipoprotein release permease component
CS374_00800	COG0463	Glycosyl transferase, family 2
CS374_00805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS374_00815	COG2246	polysaccharide biosynthetic process
CS374_00850	COG3681	Belongs to the UPF0597 family
CS374_00870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CS374_00885	COG3537	Alpha-1,2-mannosidase
CS374_00895	COG1271	oxidase subunit
CS374_00905	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS374_00910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CS374_00915	COG3250	beta-galactosidase activity
CS374_00925	COG2003	Belongs to the UPF0758 family
CS374_00930	COG1151	hydroxylamine reductase activity
CS374_00935	COG1785	Belongs to the alkaline phosphatase family
CS374_00940	COG0006	proline dipeptidase activity
CS374_00950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CS374_00970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CS374_00975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS374_00990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CS374_01085	COG4974	Belongs to the 'phage' integrase family
CS374_01260	COG0732	type I restriction modification DNA specificity domain
CS374_01360	COG0542	response to heat
CS374_01375	COG3209	COG3209 Rhs family protein
CS374_01450	COG0551	DNA topoisomerase type I activity
CS374_01450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS374_01470	COG1309	transcriptional regulator
CS374_01505	COG4948	Mandelate Racemase Muconate Lactonizing
CS374_01510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CS374_01515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CS374_01535	COG1373	ATPase (AAA superfamily
CS374_01585	COG1968	undecaprenyl-diphosphatase activity
CS374_01590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CS374_01595	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CS374_01600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CS374_01605	COG0826	peptidase U32
CS374_01615	COG3022	response to hydroperoxide
CS374_01620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS374_01650	COG4771	TonB-dependent receptor
CS374_01655	COG1429	ligase activity, forming nitrogen-metal bonds
CS374_01680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CS374_01700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CS374_01715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS374_01735	COG0730	response to heat
CS374_01740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS374_01755	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CS374_01760	COG1518	maintenance of DNA repeat elements
CS374_01770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CS374_01780	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CS374_01785	COG0714	Associated with various cellular activities
CS374_01825	COG0671	phosphoesterase, PA-phosphatase related
CS374_01830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS374_01835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CS374_01855	COG1480	7TM receptor with intracellular HD hydrolase
CS374_01860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS374_01870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CS374_01890	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CS374_01895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS374_01900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CS374_01915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CS374_01915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CS374_01925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CS374_01940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CS374_01955	COG0511	ligase activity, forming carbon-carbon bonds
CS374_01970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS374_01975	COG0346	lactoylglutathione lyase activity
CS374_01985	COG1053	succinate dehydrogenase
CS374_02000	COG2217	Heavy metal translocating P-type atpase
CS374_02000	COG2608	mercury ion transmembrane transporter activity
CS374_02005	COG2217	Heavy metal translocating P-type atpase
CS374_02010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS374_02015	COG0534	Mate efflux family protein
CS374_02020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS374_02025	COG1674	ftsk spoiiie
CS374_02040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CS374_02105	COG0500	methyltransferase
CS374_02110	COG2830	Protein of unknown function (DUF452)
CS374_02120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS374_02145	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CS374_02160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS374_02165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS374_02165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS374_02190	COG1136	(ABC) transporter
CS374_02195	COG1136	(ABC) transporter
CS374_02195	COG0577	efflux transmembrane transporter activity
CS374_02280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CS374_02285	COG0126	phosphoglycerate kinase activity
CS374_02295	COG1131	(ABC) transporter
CS374_02305	COG0438	transferase activity, transferring glycosyl groups
CS374_02330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CS374_02335	COG0009	L-threonylcarbamoyladenylate synthase
CS374_02345	COG1136	(ABC) transporter
CS374_02355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS374_02380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CS374_02385	COG0187	DNA topoisomerase II activity
CS374_02390	COG3956	TIGRFAM MazG family protein
CS374_02400	COG0564	pseudouridine synthase activity
CS374_02440	COG0259	pyridoxamine-phosphate oxidase activity
CS374_02455	COG1132	(ABC) transporter
CS374_02465	COG0557	exoribonuclease II activity
CS374_02480	COG0268	Binds directly to 16S ribosomal RNA
CS374_02490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CS374_02495	COG1546	Belongs to the CinA family
CS374_02495	COG1058	Belongs to the CinA family
CS374_02510	COG0590	tRNA wobble adenosine to inosine editing
CS374_02515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CS374_02530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CS374_02535	COG4974	Belongs to the 'phage' integrase family
CS374_02555	COG1940	carbohydrate kinase activity
CS374_02565	COG0248	Ppx GppA phosphatase
CS374_02570	COG1027	Aspartate ammonia-lyase
CS374_02575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CS374_02605	COG1253	flavin adenine dinucleotide binding
CS374_02610	COG0629	single-stranded DNA binding
CS374_02615	COG0583	DNA-binding transcription factor activity
CS374_02620	COG0708	Exodeoxyribonuclease III
CS374_02625	COG0482	sulfurtransferase activity
CS374_02630	COG0018	arginyl-trna synthetase
CS374_02640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CS374_02645	COG0719	Fe-S assembly protein
CS374_02650	COG0396	ATPase activity
CS374_02655	COG0719	Fe-S assembly protein
CS374_02665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CS374_02665	COG3266	domain, Protein
CS374_02670	COG0195	Participates in both transcription termination and antitermination
CS374_02675	COG0779	Required for maturation of 30S ribosomal subunits
CS374_02710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS374_02720	COG1011	Hydrolase
CS374_02730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CS374_02760	COG3876	Protein conserved in bacteria
CS374_02765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS374_02780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CS374_02790	COG2095	MarC family integral membrane protein
CS374_02855	COG2242	protein methyltransferase activity
CS374_02865	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CS374_02870	COG2116	formate transmembrane transporter activity
CS374_02880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CS374_02900	COG0594	ribonuclease P activity
CS374_02905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CS374_02910	COG0084	hydrolase, TatD family'
CS374_02915	COG3152	Membrane
CS374_02930	COG0612	Peptidase, M16
CS374_02935	COG1592	Rubrerythrin
CS374_02945	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CS374_02955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CS374_02980	COG4206	TonB-dependent receptor
CS374_02980	COG1629	transport
CS374_03025	COG0446	pyridine nucleotide-disulphide oxidoreductase
CS374_03040	COG0737	Belongs to the 5'-nucleotidase family
CS374_03045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS374_03045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS374_03115	COG0358	DNA primase activity
CS374_03260	COG1309	transcriptional regulator
CS374_03320	COG0582	viral genome integration into host DNA
CS374_03325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CS374_03330	COG0193	aminoacyl-tRNA hydrolase activity
CS374_03335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CS374_03360	COG3590	peptidase
CS374_03370	COG1040	competence protein
CS374_03375	COG2137	regulation of response to DNA damage stimulus
CS374_03380	COG2890	protein-(glutamine-N5) methyltransferase activity
CS374_03385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS374_03385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS374_03390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CS374_03400	COG0552	protein localization to endoplasmic reticulum
CS374_03405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS374_03435	COG2957	Belongs to the agmatine deiminase family
CS374_03445	COG1192	Involved in chromosome partitioning
CS374_03450	COG1475	DNA binding
CS374_03465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CS374_03470	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS374_03480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CS374_03485	COG2239	Acts as a magnesium transporter
CS374_03505	COG0588	phosphoglycerate mutase activity
CS374_03510	COG0438	transferase activity, transferring glycosyl groups
CS374_03520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CS374_03535	COG1739	Uncharacterized protein family UPF0029
CS374_03545	COG0776	regulation of translation
CS374_03595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS374_03600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS374_03610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS374_03610	COG0551	DNA topoisomerase type I activity
CS374_03660	COG2957	Belongs to the agmatine deiminase family
CS374_03675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS374_03680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CS374_03685	COG3104	oligopeptide transport
CS374_03710	COG0180	Tryptophanyl-tRNA synthetase
CS374_03720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CS374_03765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CS374_03770	COG0513	Belongs to the DEAD box helicase family
CS374_03820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CS374_03825	COG2022	thiamine diphosphate biosynthetic process
CS374_03830	COG0352	thiamine-phosphate diphosphorylase activity
CS374_03835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CS374_03870	COG0228	four-way junction DNA binding
CS374_03885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS374_03890	COG0252	asparaginase activity
CS374_03910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CS374_03980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CS374_03985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS374_03990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CS374_03995	COG1160	GTP binding
CS374_04005	COG0726	polysaccharide deacetylase
CS374_04010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS374_04010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CS374_04015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS374_04020	COG2233	PERMEase
CS374_04060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS374_04070	COG2166	iron-sulfur cluster assembly
CS374_04090	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS374_04095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CS374_04105	COG0423	glycine-tRNA ligase activity
CS374_04170	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS374_04175	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS374_04180	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS374_04190	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CS374_04210	COG1575	Belongs to the MenA family. Type 1 subfamily
CS374_04215	COG0019	diaminopimelate decarboxylase activity
CS374_04220	COG0527	aspartate kinase activity
CS374_04225	COG2884	Cell division ATP-binding protein ftsE
CS374_04230	COG0739	heme binding
CS374_04235	COG0012	GTP binding
CS374_04240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS374_04250	COG0326	Molecular chaperone. Has ATPase activity
CS374_04260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CS374_04265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CS374_04275	COG0335	large ribosomal subunit rRNA binding
CS374_04285	COG3118	belongs to the thioredoxin family
CS374_04315	COG0295	cytidine deaminase activity
CS374_04330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CS374_04345	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS374_04350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CS374_04355	COG0659	secondary active sulfate transmembrane transporter activity
CS374_04375	COG2205	protein histidine kinase activity
CS374_04395	COG1472	Belongs to the glycosyl hydrolase 3 family
CS374_04400	COG0542	response to heat
CS374_04420	COG1408	metallophosphoesterase
CS374_04425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CS374_04440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CS374_04480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS374_04500	COG0569	domain protein
CS374_04505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CS374_04570	COG0488	(ABC) transporter
CS374_04575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS374_04585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CS374_04590	COG0242	peptide deformylase activity
CS374_04600	COG0488	(ABC) transporter
CS374_04605	COG2957	Belongs to the agmatine deiminase family
CS374_04625	COG3852	Histidine kinase
CS374_04630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CS374_04630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CS374_04645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS374_04650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CS374_04665	COG1649	PFAM Uncharacterised BCR, COG1649
CS374_04670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS374_04695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CS374_04695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CS374_04700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS374_04705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CS374_04705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CS374_04710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CS374_04715	COG0284	orotidine-5'-phosphate decarboxylase activity
CS374_04720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CS374_04725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CS374_04730	COG1388	LysM domain
CS374_04730	COG1705	Flagellar rod assembly protein muramidase FlgJ
CS374_04765	COG1760	l-serine dehydratase
CS374_04780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS374_04780	COG0517	IMP dehydrogenase activity
CS374_04795	COG0783	Belongs to the Dps family
CS374_04820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CS374_04825	COG0217	transcriptional regulatory protein
CS374_04830	COG0072	phenylalanine-tRNA ligase activity
CS374_04830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS374_04880	COG1074	ATP-dependent DNA helicase activity
CS374_04895	COG0300	oxidoreductase activity
CS374_04905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CS374_04915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CS374_04930	COG0124	histidyl-tRNA synthetase
CS374_04935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS374_04940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CS374_04980	COG0167	dihydroorotate dehydrogenase activity
CS374_04995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS374_05015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS374_05020	COG0037	tRNA processing
CS374_05030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS374_05040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS374_05055	COG3023	N-Acetylmuramoyl-L-alanine amidase
CS374_05065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS374_05070	COG0336	Belongs to the RNA methyltransferase TrmD family
CS374_05075	COG0543	2 iron, 2 sulfur cluster binding
CS374_05080	COG0493	'glutamate synthase
CS374_05105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS374_05115	COG0406	alpha-ribazole phosphatase activity
CS374_05140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS374_05150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CS374_05160	COG3119	arylsulfatase activity
CS374_05180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS374_05185	COG1381	Involved in DNA repair and RecF pathway recombination
CS374_05190	COG4771	TonB-dependent receptor
CS374_05200	COG2855	membrane
CS374_05205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CS374_05210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CS374_05215	COG0681	Belongs to the peptidase S26 family
CS374_05230	COG0142	geranyltranstransferase activity
CS374_05245	COG1490	D-aminoacyl-tRNA deacylase activity
CS374_05250	COG0322	excinuclease ABC activity
CS374_05255	COG0445	tRNA wobble uridine modification
CS374_05305	COG0668	transmembrane transport
CS374_05315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CS374_05340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CS374_05345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CS374_05355	COG0427	acetyl-CoA hydrolase
CS374_05375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS374_05380	COG0628	permease
CS374_05410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CS374_05435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CS374_05440	COG0049	tRNA binding
CS374_05445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CS374_05450	COG0051	transcription antitermination factor activity, RNA binding
CS374_05455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CS374_05460	COG0088	Forms part of the polypeptide exit tunnel
CS374_05465	COG0089	rRNA binding
CS374_05470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CS374_05475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CS374_05480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CS374_05485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CS374_05490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CS374_05495	COG0255	Belongs to the universal ribosomal protein uL29 family
CS374_05500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CS374_05505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CS374_05510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CS374_05515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CS374_05520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CS374_05525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CS374_05530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CS374_05535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CS374_05540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CS374_05545	COG1841	ribosomal large subunit assembly
CS374_05550	COG0200	Binds to the 23S rRNA
CS374_05555	COG0201	protein transport
CS374_05565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CS374_05570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CS374_05575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CS374_05580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CS374_05585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CS374_05590	COG0202	RNA polymerase activity
CS374_05595	COG0203	ribosomal protein L17
CS374_05610	COG0528	UMP kinase activity
CS374_05615	COG0233	cytoplasmic translational termination
CS374_05620	COG1162	GTPase activity
CS374_05640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CS374_05790	COG0339	signal peptide processing
CS374_05805	COG0475	glutathione-regulated potassium exporter activity
CS374_05810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CS374_05815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS374_05815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS374_05865	COG1269	ATP hydrolysis coupled proton transport
CS374_05905	COG0358	DNA primase activity
CS374_05910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CS374_05915	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS374_05920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS374_05930	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CS374_05935	COG3005	denitrification pathway
CS374_05950	COG0148	phosphopyruvate hydratase activity
CS374_05970	COG1022	Amp-dependent synthetase and ligase
CS374_05980	COG0514	ATP-dependent DNA helicase (RecQ)
CS374_05995	COG0297	glycogen (starch) synthase activity
CS374_06005	COG2211	Major facilitator Superfamily
CS374_06040	COG0251	oxidation-reduction process
CS374_06045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS374_06050	COG0497	DNA recombination
CS374_06065	COG2176	DNA-directed DNA polymerase activity
CS374_06075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CS374_06095	COG0716	FMN binding
CS374_06100	COG1929	Belongs to the glycerate kinase type-1 family
CS374_06125	COG1755	Isoprenylcysteine carboxyl methyltransferase
CS374_06140	COG0792	nuclease activity
CS374_06155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CS374_06160	COG0215	cysteine-tRNA ligase activity
CS374_06165	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS374_06170	COG1216	Glycosyl transferase, family 2
CS374_06170	COG0463	Glycosyl transferase, family 2
CS374_06185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CS374_06190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CS374_06195	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CS374_06230	COG4974	Belongs to the 'phage' integrase family
CS374_06290	COG0156	8-amino-7-oxononanoate synthase activity
CS374_06295	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CS374_06305	COG2151	metal-sulfur cluster biosynthetic enzyme
CS374_06310	COG0484	heat shock protein binding
CS374_06315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CS374_06320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CS374_06325	COG0671	phosphoesterase, PA-phosphatase related
CS374_06330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CS374_06335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CS374_06350	COG0606	chelatase, subunit chli
CS374_06360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CS374_06365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS374_06370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS374_06375	COG0571	ribonuclease III activity
CS374_06380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS374_06390	COG1121	(ABC) transporter
CS374_06405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CS374_06420	COG3588	fructose-bisphosphate aldolase
CS374_06425	COG1506	peptidase
CS374_06425	COG0823	Involved in the tonB-independent uptake of proteins
CS374_06430	COG0709	Synthesizes selenophosphate from selenide and ATP
CS374_06450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CS374_06455	COG0698	ribose 5-phosphate isomerase
CS374_06465	COG0280	phosphate acetyltransferase
CS374_06465	COG0281	malic enzyme
CS374_06475	COG0577	efflux transmembrane transporter activity
CS374_06480	COG1136	(ABC) transporter
CS374_06485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS374_06505	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CS374_06525	COG2059	Chromate
CS374_06585	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
CS374_06585	COG2878	Part of a membrane complex involved in electron transport
CS374_06590	COG4656	Part of a membrane complex involved in electron transport
CS374_06595	COG4658	electron transport chain
CS374_06600	COG4659	FMN binding
CS374_06605	COG4660	Part of a membrane complex involved in electron transport
CS374_06610	COG4657	Part of a membrane complex involved in electron transport
CS374_06615	COG1477	protein flavinylation
CS374_06625	COG0463	Glycosyl transferase, family 2
CS374_06640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CS374_06645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CS374_06650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CS374_06670	COG1703	isobutyryl-CoA mutase activity
CS374_06685	COG2986	histidine ammonia-lyase
CS374_06690	COG3404	Formiminotransferase-cyclodeaminase
CS374_06705	COG1228	amidohydrolase
CS374_06735	COG0463	Glycosyl transferase, family 2
CS374_06740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CS374_06765	COG0626	cystathionine gamma-synthase activity
CS374_06780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CS374_06785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CS374_06790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CS374_06835	COG0540	Belongs to the ATCase OTCase family
CS374_06840	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CS374_06845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS374_06850	COG1704	LemA family
CS374_06870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CS374_06890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CS374_06920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CS374_06925	COG0052	Belongs to the universal ribosomal protein uS2 family
CS374_06930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CS374_06935	COG0556	nucleotide-excision repair
CS374_06940	COG3263	regulation of cellular component size
CS374_06950	COG0750	zinc metalloprotease
CS374_06960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CS374_06980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CS374_07000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CS374_07005	COG0081	regulation of translation
CS374_07010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CS374_07015	COG0222	ribosome binding
CS374_07020	COG0085	RNA polymerase activity
CS374_07025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CS374_07030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS374_07040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CS374_07050	COG1774	PSP1 C-terminal conserved region
CS374_07055	COG1418	mRNA catabolic process
CS374_07085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CS374_07090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CS374_07105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS374_07110	COG0514	ATP-dependent DNA helicase (RecQ)
CS374_07115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CS374_07120	COG0740	serine-type endopeptidase activity
CS374_07185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CS374_07185	COG0674	pyruvate-flavodoxin oxidoreductase activity
CS374_07190	COG1013	pyruvate-flavodoxin oxidoreductase activity
CS374_07200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS374_07210	COG4464	protein tyrosine phosphatase activity
CS374_07255	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS374_07260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS374_07265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CS374_07285	COG1253	flavin adenine dinucleotide binding
CS374_07310	COG0285	dihydrofolate synthase activity
CS374_07315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CS374_07320	COG0735	belongs to the Fur family
CS374_07330	COG1482	cell wall glycoprotein biosynthetic process
CS374_07345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CS374_07360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS374_07370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CS374_07385	COG0156	8-amino-7-oxononanoate synthase activity
CS374_07395	COG0237	dephospho-CoA kinase activity
CS374_07405	COG1862	Preprotein translocase
CS374_07410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CS374_07415	COG2255	four-way junction helicase activity
CS374_07430	COG3591	Belongs to the peptidase S1B family
CS374_07455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS374_07460	COG1854	S-ribosylhomocysteine lyase activity
CS374_07480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CS374_07485	COG1506	peptidase
CS374_07485	COG0823	Involved in the tonB-independent uptake of proteins
CS374_07490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CS374_07495	COG2957	Belongs to the agmatine deiminase family
CS374_07520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CS374_07525	COG2715	membrane protein required for spore maturation
CS374_07530	COG0194	GDP metabolic process
CS374_07540	COG0653	protein targeting
CS374_07555	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CS374_07570	COG0459	protein refolding
CS374_07575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CS374_07580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CS374_07585	COG0516	GMP reductase activity
CS374_07585	COG0517	IMP dehydrogenase activity
CS374_07595	COG0504	CTP synthase activity
CS374_07600	COG0706	membrane insertase activity
CS374_07610	COG0505	Belongs to the CarA family
CS374_07615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CS374_07620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CS374_07620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS374_07625	COG2720	vancomycin resistance protein
CS374_07670	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS374_07770	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CS374_07775	COG0402	S-adenosylhomocysteine deaminase activity
CS374_07780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS374_07785	COG2985	domain, Protein
CS374_07785	COG0569	domain protein
CS374_07815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS374_07825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CS374_07830	COG0275	rRNA processing
CS374_07845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS374_07850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS374_07855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CS374_07860	COG0772	Belongs to the SEDS family
CS374_07865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS374_07870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CS374_07880	COG0849	cell division
CS374_07885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS374_07905	COG2860	membrane
CS374_07910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CS374_07915	COG0519	Catalyzes the synthesis of GMP from XMP
CS374_07915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CS374_07920	COG0254	rRNA binding
CS374_07925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS374_07930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CS374_07935	COG0360	Binds together with S18 to 16S ribosomal RNA
CS374_07940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CS374_07945	COG0359	binds to the 23S rRNA
CS374_07955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS374_07955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS374_07970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CS374_07975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CS374_08030	COG3634	alkyl hydroperoxide reductase activity
CS374_08035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CS374_08050	COG0149	triose-phosphate isomerase activity
CS374_08060	COG0302	gtp cyclohydrolase
CS374_08075	COG0724	RNA recognition motif
CS374_08085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS374_08090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CS374_08095	COG0811	peptide transport
CS374_08110	COG0693	protein deglycase activity
CS374_08115	COG2264	protein methyltransferase activity
CS374_08120	COG0534	Mate efflux family protein
CS374_08125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CS374_08130	COG1663	tetraacyldisaccharide 4'-kinase activity
CS374_08135	COG0616	signal peptide processing
CS374_08155	COG1120	ATPase activity
CS374_08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS374_08195	COG3830	Belongs to the UPF0237 family
CS374_08195	COG0560	Phosphoserine phosphatase
CS374_08205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CS374_08210	COG0424	maF-like protein
CS374_08215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CS374_08235	COG0673	inositol 2-dehydrogenase activity
CS374_08240	COG3250	beta-galactosidase activity
CS374_08250	COG4771	TonB-dependent receptor
CS374_08255	COG4822	anaerobic cobalamin biosynthetic process
CS374_08270	COG1120	ATPase activity
CS374_08290	COG4221	oxidoreductase activity
CS374_08330	COG1136	(ABC) transporter
CS374_08340	COG1012	belongs to the aldehyde dehydrogenase family
CS374_08345	COG1454	alcohol dehydrogenase
CS374_08350	COG0427	acetyl-CoA hydrolase
CS374_08365	COG2885	chlorophyll binding
CS374_08370	COG2885	chlorophyll binding
CS374_08390	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CS374_08395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CS374_08400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CS374_08410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS374_08420	COG4771	TonB-dependent receptor
CS374_08430	COG0545	Peptidyl-prolyl cis-trans isomerase
CS374_08435	COG0545	Peptidyl-prolyl cis-trans isomerase
CS374_08445	COG0512	Glutamine amidotransferase of anthranilate synthase
CS374_08470	COG3142	Participates in the control of copper homeostasis
CS374_08495	COG5002	protein histidine kinase activity
CS374_08515	COG0791	NLP P60 protein
CS374_08520	COG1506	peptidase
CS374_08520	COG0823	Involved in the tonB-independent uptake of proteins
CS374_08525	COG1011	Hydrolase
CS374_08545	COG1181	Belongs to the D-alanine--D-alanine ligase family
CS374_08550	COG0564	pseudouridine synthase activity
CS374_08575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CS374_08580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CS374_08595	COG1234	tRNA 3'-trailer cleavage
CS374_08605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS374_08615	COG4191	Histidine kinase
CS374_08620	COG2204	response regulator
CS374_08630	COG1216	Glycosyl transferase, family 2
CS374_08640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CS374_08645	COG0826	peptidase U32
CS374_08660	COG0101	tRNA pseudouridine synthase activity
CS374_08695	COG0544	peptidyl-prolyl cis-trans isomerase activity
CS374_08700	COG1185	polyribonucleotide nucleotidyltransferase activity
CS374_08705	COG1640	4-alpha-glucanotransferase
CS374_08730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS374_08745	COG1960	acyl-CoA dehydrogenase activity
CS374_08750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS374_08755	COG2086	electron transfer activity
CS374_08760	COG1214	PFAM Peptidase M22, glycoprotease
CS374_08780	COG0811	peptide transport
CS374_08790	COG0084	hydrolase, TatD family'
CS374_08820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CS374_08825	COG0563	adenylate kinase activity
CS374_08835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CS374_08840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CS374_08845	COG0670	Belongs to the BI1 family
CS374_08850	COG0495	leucyl-tRNA aminoacylation
CS374_08865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CS374_08870	COG0617	tRNA 3'-terminal CCA addition
CS374_08880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS374_08885	COG0363	glucosamine-6-phosphate deaminase activity
CS374_08890	COG0426	domain, Protein
CS374_08895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CS374_08900	COG0673	inositol 2-dehydrogenase activity
CS374_08905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS374_08925	COG0632	four-way junction helicase activity
CS374_08955	COG4974	Belongs to the 'phage' integrase family
CS374_08960	COG4974	Belongs to the 'phage' integrase family
CS374_08990	COG2972	Histidine kinase
CS374_08995	COG3279	Response regulator of the LytR AlgR family
CS374_09065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CS374_09075	COG0784	Response regulator, receiver
CS374_09075	COG2205	protein histidine kinase activity
CS374_09075	COG5002	protein histidine kinase activity
CS374_09080	COG2197	response regulator
CS374_09090	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CS374_09110	COG2957	Belongs to the agmatine deiminase family
CS374_09120	COG2027	D-alanyl-D-alanine carboxypeptidase
CS374_09130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CS374_09160	COG2985	domain, Protein
CS374_09160	COG0569	domain protein
CS374_09205	COG3033	Beta-eliminating lyase
CS374_09235	COG0138	bifunctional purine biosynthesis protein purh
CS374_09255	COG0768	penicillin binding
CS374_09260	COG0772	Belongs to the SEDS family
CS374_09285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS374_09295	COG1280	lysine exporter protein (LysE YggA)
CS374_09315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS374_09315	COG1116	anion transmembrane transporter activity
CS374_09330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS374_09335	COG1116	anion transmembrane transporter activity
CS374_09370	COG0813	purine-nucleoside phosphorylase activity
CS374_09375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CS374_09385	COG0166	Belongs to the GPI family
CS374_09395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CS374_09400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CS374_09405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CS374_09415	COG0116	Belongs to the methyltransferase superfamily
CS374_09420	COG0823	Involved in the tonB-independent uptake of proteins
CS374_09420	COG1506	peptidase
CS374_09425	COG0151	Belongs to the GarS family
CS374_09435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS374_09455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS374_09460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CS374_09475	COG1597	lipid kinase activity
CS374_09480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CS374_09485	COG0438	transferase activity, transferring glycosyl groups
CS374_09500	COG0321	lipoyl(octanoyl) transferase activity
CS374_09500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS374_09505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CS374_09515	COG1620	l-lactate permease
CS374_09520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS374_09550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CS374_09560	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CS374_09565	COG1970	mechanosensitive ion channel activity
CS374_09575	COG1042	CoA-binding domain protein
CS374_09575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS374_09575	COG0045	succinate-CoA ligase (ADP-forming) activity
CS374_09595	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CS374_09600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CS374_09605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CS374_09640	COG1047	Peptidyl-prolyl cis-trans
CS374_09645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CS374_09675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CS374_09685	COG0357	Ribosomal RNA small subunit methyltransferase G
CS374_09690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS374_09695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CS374_09695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CS374_09725	COG0539	negative regulation of cytoplasmic translation
CS374_09740	COG1918	ferrous iron import across plasma membrane
CS374_09740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS374_09755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS374_09760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS374_09765	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CS374_09775	COG0363	glucosamine-6-phosphate deaminase activity
CS374_09780	COG3591	Belongs to the peptidase S1B family
CS374_09790	COG1193	negative regulation of DNA recombination
CS374_09805	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CS374_09810	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CS374_09825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS374_09835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS374_09845	COG1012	belongs to the aldehyde dehydrogenase family
CS374_09895	COG1328	CTP reductase activity
CS374_09900	COG0602	queuosine metabolic process
CS374_09910	COG1530	ribonuclease E activity
CS374_09915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CS374_09925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CS374_09960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CS374_09965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CS374_09975	COG0305	Participates in initiation and elongation during chromosome replication
CS374_09980	COG0481	GTPase activity
CS374_09990	COG1309	transcriptional regulator
CS374_10000	COG0564	pseudouridine synthase activity
CS374_10005	COG2197	response regulator
CS374_10015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS374_10020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS374_10040	COG0488	(ABC) transporter
CS374_10045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CS374_10060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS374_10090	COG3341	Caulimovirus viroplasmin
CS374_10090	COG0328	RNA-DNA hybrid ribonuclease activity
CS374_10100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CS374_10120	COG0443	Heat shock 70 kDa protein
CS374_10130	COG4974	Belongs to the 'phage' integrase family
CS374_10185	COG0582	viral genome integration into host DNA
CS374_10225	COG0551	DNA topoisomerase type I activity
CS374_10225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS374_10235	COG0156	8-amino-7-oxononanoate synthase activity
CS374_10245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CS374_10380	COG0358	DNA primase activity
CS374_10490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS374_10515	COG1696	Membrane protein involved in D-alanine export
CS374_10545	COG1132	(ABC) transporter
CS374_10570	COG0793	Belongs to the peptidase S41A family
CS374_10575	COG5433	transposase activity
CS374_10590	COG0167	dihydroorotate dehydrogenase activity
CS374_10600	COG1607	acyl-coa hydrolase
CS374_10605	COG3246	L-lysine catabolic process to acetate
CS374_10610	COG0604	alcohol dehydrogenase
CS374_10630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CS374_10635	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS374_10645	COG1960	acyl-CoA dehydrogenase activity
CS374_10650	COG2086	electron transfer activity
CS374_10655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS374_10660	COG1024	Enoyl-CoA hydratase
CS374_10670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CS374_10675	COG0280	phosphate acetyltransferase
CS374_10685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS374_10695	COG1242	4 iron, 4 sulfur cluster binding
CS374_10730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS374_10745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS374_10765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CS374_10775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS374_10785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CS374_10790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CS374_10795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS374_10800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS374_10805	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CS374_10810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CS374_10815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CS374_10820	COG0534	Mate efflux family protein
CS374_10830	COG0542	response to heat
CS374_10840	COG0017	Asparaginyl-tRNA synthetase
CS374_10845	COG1187	pseudouridine synthase activity
CS374_10855	COG2096	Adenosyltransferase
CS374_10865	COG2233	PERMEase
CS374_10870	COG1522	sequence-specific DNA binding
CS374_10875	COG1570	exodeoxyribonuclease VII activity