locus-tag	class	description
P9301_00001	COG0592	DNA-directed DNA polymerase activity
P9301_00021	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P9301_00041	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P9301_00081	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P9301_00091	COG0552	protein localization to endoplasmic reticulum
P9301_00101	COG2208	phosphoserine phosphatase activity
P9301_00111	COG0165	Argininosuccinate lyase
P9301_00121	COG0724	RNA recognition motif
P9301_00131	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P9301_00151	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P9301_00161	COG0484	heat shock protein binding
P9301_00181	COG1162	GTPase activity
P9301_00191	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
P9301_00201	COG0812	UDP-N-acetylmuramate dehydrogenase activity
P9301_00211	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P9301_00221	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P9301_00231	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P9301_00241	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P9301_00251	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P9301_00261	COG0511	ligase activity, forming carbon-carbon bonds
P9301_00271	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
P9301_00351	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
P9301_00361	COG0519	Catalyzes the synthesis of GMP from XMP
P9301_00391	COG0457	Tetratricopeptide repeat
P9301_00431	COG0768	penicillin binding
P9301_00451	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P9301_00451	COG0426	domain, Protein
P9301_00461	COG0426	domain, Protein
P9301_00461	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P9301_00471	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P9301_00481	COG1166	arginine decarboxylase activity
P9301_00491	COG0105	UTP biosynthetic process
P9301_00501	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P9301_00501	COG2022	thiamine diphosphate biosynthetic process
P9301_00511	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P9301_00521	COG0237	dephospho-CoA kinase activity
P9301_00531	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
P9301_00621	COG0116	Belongs to the methyltransferase superfamily
P9301_00681	COG1196	nuclear chromosome segregation
P9301_00711	COG0439	Biotin carboxylase
P9301_00741	COG0515	serine threonine protein kinase
P9301_00761	COG4178	(ABC) transporter
P9301_00781	COG0537	adenosine 5'-monophosphoramidase activity
P9301_00791	COG0242	peptide deformylase activity
P9301_00811	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P9301_00821	COG0719	Fe-S assembly protein
P9301_00831	COG0396	ATPase activity
P9301_00841	COG0719	Fe-S assembly protein
P9301_00881	COG0033	Phosphoglucomutase
P9301_00891	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P9301_00911	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P9301_00921	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
P9301_00931	COG0175	sulfate reduction
P9301_00941	COG1252	NADH dehydrogenase
P9301_00951	COG0471	metal ion transport
P9301_00951	COG3273	potassium ion transport
P9301_00961	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P9301_00971	COG0569	domain protein
P9301_01021	COG0488	(ABC) transporter
P9301_01041	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P9301_01151	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
P9301_01161	COG4243	Vitamin k epoxide reductase
P9301_01171	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P9301_01291	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
P9301_01301	COG1587	Uroporphyrinogen-III synthase
P9301_01321	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
P9301_01331	COG0316	Belongs to the HesB IscA family
P9301_01371	COG1090	epimerase
P9301_01391	COG0484	heat shock protein binding
P9301_01401	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P9301_01471	COG0745	RESPONSE REGULATOR receiver
P9301_01481	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P9301_01491	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P9301_01501	COG2217	Heavy metal translocating P-type atpase
P9301_01511	COG3063	Type IV pilus biogenesis stability protein PilW
P9301_01521	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
P9301_01541	COG0416	fatty acid biosynthetic process
P9301_01551	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P9301_01561	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
P9301_01601	COG0617	tRNA 3'-terminal CCA addition
P9301_01621	COG1562	ergosterol biosynthetic process
P9301_01631	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
P9301_01631	COG0493	'glutamate synthase
P9301_01661	COG0583	DNA-binding transcription factor activity
P9301_01681	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P9301_01691	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_01711	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
P9301_01731	COG2197	response regulator
P9301_01761	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P9301_01771	COG0713	ATP synthesis coupled electron transport
P9301_01781	COG0839	Belongs to the complex I subunit 6 family
P9301_01791	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_01801	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
P9301_01811	COG0372	Belongs to the citrate synthase family
P9301_01841	COG0133	tryptophan synthase activity
P9301_01851	COG0023	Translation Initiation Factor
P9301_01861	COG0529	Catalyzes the synthesis of activated sulfate
P9301_01871	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
P9301_01881	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P9301_01891	COG0745	RESPONSE REGULATOR receiver
P9301_01911	COG0275	rRNA processing
P9301_01921	COG0649	NAD binding
P9301_01931	COG0824	Thioesterase
P9301_01961	COG1575	Belongs to the MenA family. Type 1 subfamily
P9301_01971	COG1169	isochorismate synthase
P9301_01981	COG0189	ligase activity
P9301_01991	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P9301_02001	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P9301_02021	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P9301_02051	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
P9301_02071	COG0018	arginyl-trna synthetase
P9301_02081	COG0157	Belongs to the NadC ModD family
P9301_02091	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P9301_02111	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P9301_02121	COG4172	Belongs to the ABC transporter superfamily
P9301_02131	COG0564	pseudouridine synthase activity
P9301_02141	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
P9301_02151	COG0126	phosphoglycerate kinase activity
P9301_02171	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P9301_02181	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
P9301_02191	COG0167	dihydroorotate dehydrogenase activity
P9301_02201	COG0328	RNA-DNA hybrid ribonuclease activity
P9301_02211	COG0222	ribosome binding
P9301_02221	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P9301_02231	COG0081	regulation of translation
P9301_02241	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P9301_02251	COG0250	Participates in transcription elongation, termination and antitermination
P9301_02261	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
P9301_02271	COG0542	response to heat
P9301_02281	COG0148	phosphopyruvate hydratase activity
P9301_02291	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P9301_02311	COG0492	ferredoxin-NADP+ reductase activity
P9301_02351	COG0659	secondary active sulfate transmembrane transporter activity
P9301_02361	COG0113	porphobilinogen synthase activity
P9301_02381	COG1193	negative regulation of DNA recombination
P9301_02391	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
P9301_02421	COG0435	Glutathione S-transferase
P9301_02431	COG2988	succinylglutamate desuccinylase activity
P9301_02461	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
P9301_02481	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9301_02491	COG0529	Catalyzes the synthesis of activated sulfate
P9301_02491	COG2046	Belongs to the sulfate adenylyltransferase family
P9301_02511	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P9301_02521	COG3536	Protein conserved in bacteria
P9301_02551	COG0540	Belongs to the ATCase OTCase family
P9301_02561	COG2094	Belongs to the DNA glycosylase MPG family
P9301_02571	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P9301_02601	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
P9301_02631	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P9301_02641	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P9301_02651	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P9301_02661	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
P9301_02671	COG0717	Belongs to the dCTP deaminase family
P9301_02691	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P9301_02701	COG4372	Transposase
P9301_02731	COG0193	aminoacyl-tRNA hydrolase activity
P9301_02781	COG0066	3-isopropylmalate dehydratase activity
P9301_02791	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
P9301_02801	COG1546	Belongs to the CinA family
P9301_02801	COG1058	Belongs to the CinA family
P9301_02811	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
P9301_02841	COG0728	peptidoglycan biosynthetic process
P9301_02851	COG1489	DNA binding
P9301_02861	COG0004	ammonium transporteR
P9301_02871	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
P9301_02891	COG0138	bifunctional purine biosynthesis protein purh
P9301_02921	COG5002	protein histidine kinase activity
P9301_02931	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
P9301_02941	COG0343	queuine tRNA-ribosyltransferase activity
P9301_02961	COG0673	inositol 2-dehydrogenase activity
P9301_02981	COG1253	flavin adenine dinucleotide binding
P9301_02991	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P9301_03021	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P9301_03031	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
P9301_03041	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
P9301_03051	COG0131	Imidazoleglycerol-phosphate dehydratase
P9301_03061	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P9301_03091	COG0415	Belongs to the DNA photolyase family
P9301_03111	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P9301_03121	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
P9301_03121	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
P9301_03141	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
P9301_03151	COG0391	Required for morphogenesis under gluconeogenic growth conditions
P9301_03161	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_03171	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_03181	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_03191	COG1773	rubredoxin
P9301_03201	COG4447	cellulose binding
P9301_03251	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
P9301_03261	COG0709	Synthesizes selenophosphate from selenide and ATP
P9301_03271	COG0617	tRNA 3'-terminal CCA addition
P9301_03351	COG1070	Carbohydrate kinase
P9301_03361	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P9301_03371	COG0539	negative regulation of cytoplasmic translation
P9301_03381	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P9301_03431	COG2890	protein-(glutamine-N5) methyltransferase activity
P9301_03461	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
P9301_03471	COG2894	cell division
P9301_03481	COG0850	regulation of cytokinetic process
P9301_03491	COG1078	dGTPase activity
P9301_03501	COG0793	Belongs to the peptidase S41A family
P9301_03511	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P9301_03521	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P9301_03551	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P9301_03581	COG1012	belongs to the aldehyde dehydrogenase family
P9301_03761	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P9301_03801	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P9301_03921	COG0415	Belongs to the DNA photolyase family
P9301_03941	COG0351	phosphomethylpyrimidine kinase
P9301_04071	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
P9301_04111	COG1160	GTP binding
P9301_04121	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
P9301_04141	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
P9301_04151	COG1799	cell septum assembly
P9301_04161	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
P9301_04201	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
P9301_04211	COG0321	lipoyl(octanoyl) transferase activity
P9301_04221	COG1022	Amp-dependent synthetase and ligase
P9301_04241	COG0508	dehydrogenase complex catalyzes the overall conversion of
P9301_04251	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
P9301_04261	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P9301_04271	COG0626	cystathionine gamma-synthase activity
P9301_04281	COG0626	cystathionine gamma-synthase activity
P9301_04291	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P9301_04301	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
P9301_04321	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P9301_04351	COG2226	methyltransferase
P9301_04381	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
P9301_04391	COG0579	oxidoreductase
P9301_04401	COG0481	GTPase activity
P9301_04421	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P9301_04471	COG3046	protein related to deoxyribodipyrimidine photolyase
P9301_04501	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
P9301_04501	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P9301_04511	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P9301_04521	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P9301_04541	COG0107	imidazoleglycerol-phosphate synthase activity
P9301_04551	COG2226	methyltransferase
P9301_04581	COG1136	(ABC) transporter
P9301_04591	COG1007	ATP synthesis coupled electron transport
P9301_04601	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P9301_04631	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
P9301_04681	COG1845	cytochrome c oxidase, subunit III
P9301_04691	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P9301_04721	COG0109	protoheme IX farnesyltransferase activity
P9301_04761	COG0459	protein refolding
P9301_04781	COG1028	Short-chain dehydrogenase reductase Sdr
P9301_04791	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
P9301_04801	COG1619	proteins homologs of microcin C7 resistance protein MccF
P9301_04811	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P9301_04821	COG0248	Ppx GppA phosphatase
P9301_04851	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P9301_04861	COG3258	Cytochrome c
P9301_04871	COG0723	plastoquinol--plastocyanin reductase activity
P9301_04891	COG0805	protein transport
P9301_04921	COG0194	GDP metabolic process
P9301_04951	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
P9301_04981	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P9301_05001	COG0335	large ribosomal subunit rRNA binding
P9301_05021	COG0024	Methionine aminopeptidase
P9301_05031	COG3000	fatty acid hydroxylase
P9301_05031	COG0300	oxidoreductase activity
P9301_05041	COG0857	belongs to the CobB CobQ family
P9301_05061	COG1666	GTP binding
P9301_05101	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
P9301_05141	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
P9301_05161	COG1178	ABC-type Fe3 transport system permease component
P9301_05171	COG0523	cobalamin synthesis protein
P9301_05181	COG2154	pterin-4-alpha-carbinolamine dehydratase
P9301_05191	COG0432	Pfam Uncharacterised protein family UPF0047
P9301_05201	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
P9301_05211	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P9301_05221	COG0181	hydroxymethylbilane synthase activity
P9301_05231	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9301_05241	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P9301_05261	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P9301_05291	COG0629	single-stranded DNA binding
P9301_05321	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P9301_05331	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
P9301_05351	COG0442	prolyl-tRNA aminoacylation
P9301_05381	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P9301_05391	COG1393	Belongs to the ArsC family
P9301_05401	COG0681	Belongs to the peptidase S26 family
P9301_05411	COG0406	alpha-ribazole phosphatase activity
P9301_05441	COG0768	penicillin binding
P9301_05451	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P9301_05461	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
P9301_05471	COG0233	cytoplasmic translational termination
P9301_05481	COG0528	UMP kinase activity
P9301_05501	COG0582	viral genome integration into host DNA
P9301_05511	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
P9301_05521	COG0028	Belongs to the TPP enzyme family
P9301_05561	COG0539	negative regulation of cytoplasmic translation
P9301_05581	COG3396	Phenylacetate-CoA oxygenase
P9301_05591	COG5322	oxidoreductase activity
P9301_05601	COG0825	malonyl-CoA metabolic process
P9301_05621	COG0302	gtp cyclohydrolase
P9301_05641	COG1994	Peptidase M50
P9301_05641	COG0517	IMP dehydrogenase activity
P9301_05651	COG0095	Lipoate-protein ligase
P9301_05691	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
P9301_05701	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
P9301_05711	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
P9301_05741	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
P9301_05761	COG1850	ribulose-bisphosphate carboxylase activity
P9301_05771	COG4451	ribulose bisphosphate carboxylase, small
P9301_05841	COG0251	oxidation-reduction process
P9301_05851	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P9301_05861	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
P9301_05871	COG1132	(ABC) transporter
P9301_05881	COG0456	acetyltransferase
P9301_05911	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
P9301_05931	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P9301_05951	COG0418	dihydroorotase activity
P9301_05981	COG0159	tryptophan synthase activity
P9301_06031	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9301_06041	COG0140	phosphoribosyl-ATP diphosphatase activity
P9301_06041	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
P9301_06061	COG0542	response to heat
P9301_06071	COG3794	PFAM blue (type 1) copper domain protein
P9301_06091	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
P9301_06101	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
P9301_06161	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
P9301_06171	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P9301_06191	COG0339	signal peptide processing
P9301_06201	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_06211	COG0083	homoserine kinase activity
P9301_06221	COG0837	glucose binding
P9301_06231	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
P9301_06241	COG0180	Tryptophanyl-tRNA synthetase
P9301_06281	COG1121	(ABC) transporter
P9301_06291	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P9301_06331	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
P9301_06341	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
P9301_06351	COG0297	glycogen (starch) synthase activity
P9301_06361	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
P9301_06371	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
P9301_06381	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P9301_06381	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
P9301_06391	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
P9301_06401	COG2045	Belongs to the ComB family
P9301_06411	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P9301_06421	COG0860	N-Acetylmuramoyl-L-alanine amidase
P9301_06441	COG0142	geranyltranstransferase activity
P9301_06451	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
P9301_06471	COG2176	DNA-directed DNA polymerase activity
P9301_06491	COG0124	histidyl-tRNA synthetase
P9301_06591	COG0300	oxidoreductase activity
P9301_06601	COG0644	oxidoreductase
P9301_06631	COG1335	isochorismatase
P9301_06641	COG0735	belongs to the Fur family
P9301_06701	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
P9301_06711	COG0659	secondary active sulfate transmembrane transporter activity
P9301_06791	COG0346	lactoylglutathione lyase activity
P9301_06881	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P9301_06891	COG1459	type II secretion system
P9301_06911	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P9301_06981	COG4969	Belongs to the N-Me-Phe pilin family
P9301_07011	COG4968	Prepilin-type N-terminal cleavage methylation domain
P9301_07151	COG4106	trans-aconitate 2-methyltransferase activity
P9301_07161	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
P9301_07181	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
P9301_07211	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P9301_07221	COG1836	PFAM Integral membrane protein DUF92
P9301_07261	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
P9301_07271	COG0436	Aminotransferase
P9301_07281	COG1573	uracil-dna glycosylase
P9301_07291	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
P9301_07301	COG0793	Belongs to the peptidase S41A family
P9301_07351	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
P9301_07361	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P9301_07741	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P9301_07771	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
P9301_07821	COG1201	RNA secondary structure unwinding
P9301_07831	COG1793	dna ligase
P9301_08021	COG0740	serine-type endopeptidase activity
P9301_08031	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9301_08061	COG0612	Peptidase, M16
P9301_08121	COG1216	Glycosyl transferase, family 2
P9301_08131	COG0052	Belongs to the universal ribosomal protein uS2 family
P9301_08141	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P9301_08161	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P9301_08171	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
P9301_08181	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
P9301_08191	COG0751	glycine-tRNA ligase activity
P9301_08201	COG0644	oxidoreductase
P9301_08241	COG1137	ATPase activity
P9301_08251	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P9301_08271	COG1494	fructose-1,6-bisphosphatase
P9301_08281	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
P9301_08291	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
P9301_08301	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
P9301_08311	COG0363	glucosamine-6-phosphate deaminase activity
P9301_08341	COG0129	dihydroxy-acid dehydratase activity
P9301_08361	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
P9301_08401	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P9301_08411	COG0047	phosphoribosylformylglycinamidine synthase activity
P9301_08421	COG0191	fructose-bisphosphate aldolase activity
P9301_08431	COG0673	inositol 2-dehydrogenase activity
P9301_08451	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
P9301_08461	COG3954	Phosphoribulokinase
P9301_08471	COG0473	3-isopropylmalate dehydrogenase activity
P9301_08481	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P9301_08491	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
P9301_08521	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
P9301_08561	COG2197	response regulator
P9301_08571	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
P9301_08591	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P9301_08631	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P9301_08641	COG3842	ATPase activity
P9301_08671	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P9301_08681	COG1119	ATPase activity
P9301_08851	COG0559	Belongs to the binding-protein-dependent transport system permease family
P9301_08871	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
P9301_08881	COG0830	nickel cation binding
P9301_08891	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
P9301_08901	COG0829	nickel cation binding
P9301_08911	COG0831	urea catabolic process
P9301_08921	COG0832	Belongs to the urease beta subunit family
P9301_08931	COG0804	urea catabolic process
P9301_08941	COG0463	Glycosyl transferase, family 2
P9301_08951	COG0366	Alpha amylase catalytic
P9301_08961	COG3769	mannosylglycerate metabolic process
P9301_09021	COG1968	undecaprenyl-diphosphatase activity
P9301_09041	COG1132	(ABC) transporter
P9301_09061	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
P9301_09071	COG0505	Belongs to the CarA family
P9301_09091	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
P9301_09101	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P9301_09121	COG0154	amidase activity
P9301_09131	COG0587	DNA-directed DNA polymerase activity
P9301_09151	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
P9301_09161	COG0632	four-way junction helicase activity
P9301_09191	COG0358	DNA primase activity
P9301_09211	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
P9301_09221	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P9301_09231	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
P9301_09251	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P9301_09261	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
P9301_09281	COG0022	dehydrogenase e1 component
P9301_09281	COG0508	dehydrogenase complex catalyzes the overall conversion of
P9301_09291	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P9301_09301	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P9301_09341	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
P9301_09351	COG0515	serine threonine protein kinase
P9301_09391	COG0174	glutamine synthetase
P9301_09401	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
P9301_09411	COG0590	tRNA wobble adenosine to inosine editing
P9301_09421	COG0076	glutamate decarboxylase activity
P9301_09441	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
P9301_09471	COG0469	pyruvate kinase activity
P9301_09511	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
P9301_09521	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
P9301_09561	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P9301_09571	COG0227	Belongs to the bacterial ribosomal protein bL28 family
P9301_09581	COG0326	Molecular chaperone. Has ATPase activity
P9301_09591	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
P9301_09601	COG0483	inositol monophosphate 1-phosphatase activity
P9301_09611	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
P9301_09621	COG0443	Heat shock 70 kDa protein
P9301_09631	COG0484	heat shock protein binding
P9301_09651	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P9301_09661	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P9301_09661	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P9301_09671	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
P9301_09691	COG0166	Belongs to the GPI family
P9301_09701	COG0495	leucyl-tRNA aminoacylation
P9301_09721	COG1104	cysteine desulfurase activity
P9301_09751	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
P9301_09761	COG0426	domain, Protein
P9301_09761	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P9301_09771	COG0322	excinuclease ABC activity
P9301_09811	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P9301_09821	COG1410	methionine synthase
P9301_09821	COG0646	methionine synthase
P9301_09891	COG0072	phenylalanine-tRNA ligase activity
P9301_09901	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P9301_09911	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P9301_09921	COG0557	exoribonuclease II activity
P9301_09931	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P9301_09981	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
P9301_09991	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
P9301_10121	COG0450	alkyl hydroperoxide reductase
P9301_10141	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9301_10151	COG0333	Belongs to the bacterial ribosomal protein bL32 family
P9301_10191	COG2119	membrane
P9301_10211	COG0557	exoribonuclease II activity
P9301_10241	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
P9301_10251	COG0312	modulator of DNA gyrase
P9301_10271	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P9301_10281	COG0861	Integral membrane protein TerC family
P9301_10301	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P9301_10381	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
P9301_10391	COG1429	ligase activity, forming nitrogen-metal bonds
P9301_10401	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P9301_10411	COG0149	triose-phosphate isomerase activity
P9301_10431	COG1132	(ABC) transporter
P9301_10451	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
P9301_10471	COG0799	negative regulation of ribosome biogenesis
P9301_10511	COG4555	ABC transporter
P9301_10681	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P9301_10701	COG0572	uridine kinase
P9301_10751	COG3340	Belongs to the peptidase S51 family
P9301_10901	COG0308	aminopeptidase N
P9301_10931	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
P9301_10981	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P9301_11311	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P9301_11331	COG1121	(ABC) transporter
P9301_11341	COG0803	Belongs to the bacterial solute-binding protein 9 family
P9301_11351	COG0523	cobalamin synthesis protein
P9301_11431	COG2308	Evidence 4 Homologs of previously reported genes of
P9301_11571	COG0460	homoserine dehydrogenase
P9301_11581	COG2166	iron-sulfur cluster assembly
P9301_11601	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
P9301_11611	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
P9301_11621	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
P9301_11661	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P9301_11671	COG3118	belongs to the thioredoxin family
P9301_11681	COG0516	GMP reductase activity
P9301_11691	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P9301_11701	COG0644	oxidoreductase
P9301_11711	COG1543	Belongs to the glycosyl hydrolase 57 family
P9301_11721	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
P9301_11741	COG1480	7TM receptor with intracellular HD hydrolase
P9301_11751	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P9301_11761	COG0142	geranyltranstransferase activity
P9301_11781	COG1797	cobyrinic acid a,c-diamide synthase activity
P9301_11811	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
P9301_11821	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
P9301_11841	COG2205	protein histidine kinase activity
P9301_11871	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
P9301_11881	COG1640	4-alpha-glucanotransferase
P9301_11901	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P9301_11911	COG1982	Orn Lys Arg decarboxylase major
P9301_11921	COG0575	Belongs to the CDS family
P9301_11941	COG0371	Dehydrogenase
P9301_11951	COG0542	response to heat
P9301_11971	COG0019	diaminopimelate decarboxylase activity
P9301_11981	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
P9301_11991	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P9301_12001	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P9301_12031	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P9301_12041	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
P9301_12061	COG1132	(ABC) transporter
P9301_12081	COG0513	Belongs to the DEAD box helicase family
P9301_12091	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P9301_12101	COG1074	ATP-dependent DNA helicase activity
P9301_12141	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
P9301_12151	COG0204	Acyl-transferase
P9301_12151	COG0318	PFAM AMP-dependent synthetase and ligase
P9301_12171	COG0271	Belongs to the BolA IbaG family
P9301_12181	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
P9301_12201	COG0745	RESPONSE REGULATOR receiver
P9301_12221	COG1233	COG1233 Phytoene dehydrogenase and related
P9301_12231	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
P9301_12301	COG3128	pkhd-type hydroxylase
P9301_12351	COG0640	Transcriptional regulator
P9301_12361	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P9301_12381	COG2059	Chromate
P9301_12391	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
P9301_12431	COG0745	RESPONSE REGULATOR receiver
P9301_12501	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
P9301_12511	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
P9301_12581	COG0798	PFAM Bile acid sodium symporter
P9301_12621	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P9301_12651	COG1053	succinate dehydrogenase
P9301_12681	COG1187	pseudouridine synthase activity
P9301_12701	COG2135	peptidase activity
P9301_13021	COG0733	neurotransmitter:sodium symporter activity
P9301_13091	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
P9301_13111	COG2072	flavoprotein involved in K transport
P9301_13161	COG2144	transferase activity, transferring acyl groups
P9301_13271	COG0012	GTP binding
P9301_13291	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P9301_13291	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P9301_13301	COG0215	cysteine-tRNA ligase activity
P9301_13311	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P9301_13331	COG3411	Ferredoxin
P9301_13341	COG1073	alpha beta
P9301_13351	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
P9301_13371	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
P9301_13411	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
P9301_13461	COG0440	acetolactate synthase activity
P9301_13471	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P9301_13511	COG0424	maF-like protein
P9301_13521	COG1492	cobalamin metabolic process
P9301_13611	COG1840	ABC-type Fe3 transport system, periplasmic component
P9301_13621	COG3128	pkhd-type hydroxylase
P9301_13651	COG0752	glycyl-tRNA synthetase alpha subunit
P9301_13731	COG0716	FMN binding
P9301_13781	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
P9301_13791	COG0438	transferase activity, transferring glycosyl groups
P9301_13801	COG0697	spore germination
P9301_13811	COG0616	signal peptide processing
P9301_13841	COG0230	Belongs to the bacterial ribosomal protein bL34 family
P9301_13851	COG0594	ribonuclease P activity
P9301_13871	COG0706	membrane insertase activity
P9301_13881	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9301_13891	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
P9301_13901	COG0750	zinc metalloprotease
P9301_13911	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
P9301_13921	COG1185	polyribonucleotide nucleotidyltransferase activity
P9301_13931	COG1218	3'(2'),5'-bisphosphate nucleotidase
P9301_13941	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
P9301_13981	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P9301_14001	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P9301_14001	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P9301_14031	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
P9301_14051	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
P9301_14071	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
P9301_14081	COG2089	acid synthase
P9301_14101	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
P9301_14111	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P9301_14121	COG1028	Short-chain dehydrogenase reductase Sdr
P9301_14131	COG1083	cytidylyl-transferase
P9301_14151	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
P9301_14161	COG1215	transferase activity, transferring glycosyl groups
P9301_14231	COG1132	(ABC) transporter
P9301_14241	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
P9301_14251	COG0438	transferase activity, transferring glycosyl groups
P9301_14251	COG0297	glycogen (starch) synthase activity
P9301_14271	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P9301_14301	COG0107	imidazoleglycerol-phosphate synthase activity
P9301_14361	COG1834	amidinotransferase
P9301_14391	COG1028	Short-chain dehydrogenase reductase Sdr
P9301_14411	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
P9301_14441	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
P9301_14451	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P9301_14471	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
P9301_14481	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
P9301_14491	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P9301_14501	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P9301_14501	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P9301_14541	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P9301_14551	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
P9301_14561	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
P9301_14581	COG0196	riboflavin kinase activity
P9301_14591	COG0352	thiamine-phosphate diphosphorylase activity
P9301_14631	COG1691	(AIR) carboxylase
P9301_14651	COG0336	Belongs to the RNA methyltransferase TrmD family
P9301_14691	COG1702	phosphate starvation-inducible protein PhoH
P9301_14701	COG0228	four-way junction DNA binding
P9301_14711	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P9301_14731	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
P9301_14741	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9301_14751	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P9301_14751	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P9301_14761	COG0482	sulfurtransferase activity
P9301_14771	COG0815	Transfers the fatty acyl group on membrane lipoproteins
P9301_14821	COG0134	indole-3-glycerol-phosphate synthase activity
P9301_14831	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P9301_14841	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P9301_14851	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P9301_14871	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P9301_14881	COG0285	dihydrofolate synthase activity
P9301_14911	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P9301_14921	COG1181	Belongs to the D-alanine--D-alanine ligase family
P9301_14951	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
P9301_14961	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
P9301_14971	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P9301_14981	COG4956	integral membrane protein (PIN domain superfamily)
P9301_14991	COG0740	serine-type endopeptidase activity
P9301_15001	COG0740	serine-type endopeptidase activity
P9301_15011	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
P9301_15021	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
P9301_15071	COG0776	regulation of translation
P9301_15081	COG1523	belongs to the glycosyl hydrolase 13 family
P9301_15091	COG2211	Major facilitator Superfamily
P9301_15101	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P9301_15131	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
P9301_15141	COG0284	orotidine-5'-phosphate decarboxylase activity
P9301_15151	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
P9301_15181	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
P9301_15191	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P9301_15221	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P9301_15241	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P9301_15251	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
P9301_15261	COG0151	Belongs to the GarS family
P9301_15271	COG5002	protein histidine kinase activity
P9301_15281	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
P9301_15291	COG4251	negative regulation of phosphorylation
P9301_15301	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P9301_15311	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P9301_15321	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P9301_15331	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
P9301_15341	COG2385	sporulation resulting in formation of a cellular spore
P9301_15351	COG1234	tRNA 3'-trailer cleavage
P9301_15391	COG2264	protein methyltransferase activity
P9301_15401	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P9301_15421	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P9301_15481	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P9301_15491	COG4221	oxidoreductase activity
P9301_15511	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
P9301_15581	COG2081	HI0933 family
P9301_16231	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
P9301_16241	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
P9301_16261	COG0459	protein refolding
P9301_16271	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P9301_16281	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P9301_16291	COG0355	proton-transporting ATP synthase activity, rotational mechanism
P9301_16321	COG0006	proline dipeptidase activity
P9301_16341	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P9301_16351	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
P9301_16361	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
P9301_16361	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P9301_16371	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P9301_16401	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
P9301_16411	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
P9301_16421	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P9301_16431	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P9301_16451	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P9301_16461	COG0356	it plays a direct role in the translocation of protons across the membrane
P9301_16481	COG0772	Belongs to the SEDS family
P9301_16491	COG0785	Cytochrome C biogenesis protein
P9301_16501	COG1333	cytochrome c biogenesis protein
P9301_16511	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
P9301_16531	COG0347	Belongs to the P(II) protein family
P9301_16541	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
P9301_16551	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
P9301_16561	COG0114	fumarate hydratase activity
P9301_16571	COG4581	dead DEAH box helicase
P9301_16611	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P9301_16621	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P9301_16651	COG0357	Ribosomal RNA small subunit methyltransferase G
P9301_16721	COG0820	rRNA (adenine-C2-)-methyltransferase activity
P9301_16741	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P9301_16751	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P9301_16761	COG0085	RNA polymerase activity
P9301_16771	COG0084	hydrolase, TatD family'
P9301_16781	COG0268	Binds directly to 16S ribosomal RNA
P9301_16791	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
P9301_16801	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
P9301_16811	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P9301_16821	COG0779	Required for maturation of 30S ribosomal subunits
P9301_16831	COG0195	Participates in both transcription termination and antitermination
P9301_16851	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
P9301_16901	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
P9301_16911	COG0436	Aminotransferase
P9301_16921	COG1530	ribonuclease E activity
P9301_16931	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P9301_16951	COG1605	Chorismate mutase
P9301_16951	COG0077	Prephenate dehydratase
P9301_16961	COG2226	methyltransferase
P9301_16971	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P9301_16981	COG0051	transcription antitermination factor activity, RNA binding
P9301_16991	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P9301_17001	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P9301_17011	COG0049	tRNA binding
P9301_17021	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P9301_17041	COG0069	glutamate synthase activity
P9301_17041	COG0070	glutamate synthase
P9301_17041	COG0067	glutamate synthase
P9301_17061	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P9301_17141	COG0463	Glycosyl transferase, family 2
P9301_17151	COG2885	chlorophyll binding
P9301_17161	COG2885	chlorophyll binding
P9301_17191	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
P9301_17211	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
P9301_17221	COG0254	rRNA binding
P9301_17231	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P9301_17241	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P9301_17251	COG0101	tRNA pseudouridine synthase activity
P9301_17261	COG0203	ribosomal protein L17
P9301_17271	COG0202	RNA polymerase activity
P9301_17281	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P9301_17291	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P9301_17301	COG0563	adenylate kinase activity
P9301_17311	COG0201	protein transport
P9301_17321	COG0200	Binds to the 23S rRNA
P9301_17331	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
P9301_17341	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P9301_17351	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
P9301_17361	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P9301_17371	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P9301_17381	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
P9301_17391	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
P9301_17401	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
P9301_17411	COG0255	Belongs to the universal ribosomal protein uL29 family
P9301_17421	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P9301_17431	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P9301_17441	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P9301_17451	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P9301_17461	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
P9301_17471	COG0089	rRNA binding
P9301_17481	COG0088	Forms part of the polypeptide exit tunnel
P9301_17491	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
P9301_17531	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
P9301_17611	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
P9301_17621	COG1606	tRNA processing
P9301_17631	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
P9301_17641	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
P9301_17661	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
P9301_17681	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P9301_17711	COG0772	Belongs to the SEDS family
P9301_17721	COG0489	protein tyrosine kinase activity
P9301_17731	COG0408	coproporphyrinogen oxidase activity
P9301_17811	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P9301_17821	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
P9301_17821	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
P9301_17831	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P9301_17861	COG5398	heme oxygenase
P9301_17881	COG0538	isocitrate dehydrogenase activity
P9301_17921	COG0475	glutathione-regulated potassium exporter activity
P9301_17931	COG0058	SHG alpha-glucan phosphorylase activity
P9301_17961	COG0571	ribonuclease III activity
P9301_17981	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
P9301_17991	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
P9301_18001	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P9301_18011	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P9301_18021	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P9301_18031	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P9301_18041	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
P9301_18051	COG1473	amidohydrolase
P9301_18071	COG2255	four-way junction helicase activity
P9301_18081	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P9301_18101	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
P9301_18111	COG0745	RESPONSE REGULATOR receiver
P9301_18151	COG0629	single-stranded DNA binding
P9301_18161	COG0586	Pfam SNARE associated Golgi protein
P9301_18171	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
P9301_18181	COG0802	atpase or kinase
P9301_18211	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9301_18221	COG2239	Acts as a magnesium transporter
P9301_18251	COG0187	DNA topoisomerase II activity
P9301_18251	COG1372	Participates in initiation and elongation during chromosome replication
P9301_18261	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P9301_18271	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P9301_18281	COG1725	Transcriptional regulator
P9301_18291	COG1045	serine acetyltransferase
P9301_18301	COG0653	protein targeting
P9301_18331	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
P9301_18351	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
P9301_18361	COG2082	Precorrin-8x methylmutase
P9301_18391	COG0556	nucleotide-excision repair
P9301_18411	COG0037	tRNA processing
P9301_18421	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
P9301_18431	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P9301_18441	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P9301_18451	COG0544	peptidyl-prolyl cis-trans isomerase activity
P9301_18461	COG0740	serine-type endopeptidase activity
P9301_18471	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
P9301_18481	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P9301_18501	COG2385	sporulation resulting in formation of a cellular spore
P9301_18511	COG0291	Belongs to the bacterial ribosomal protein bL35 family
P9301_18521	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P9301_18541	COG2022	thiamine diphosphate biosynthetic process
P9301_18551	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
P9301_18561	COG0438	transferase activity, transferring glycosyl groups
P9301_18561	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P9301_18581	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P9301_18581	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P9301_18591	COG0509	glycine decarboxylation via glycine cleavage system
P9301_18601	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
P9301_18631	COG0359	binds to the 23S rRNA
P9301_18641	COG1372	Participates in initiation and elongation during chromosome replication
P9301_18641	COG0305	Participates in initiation and elongation during chromosome replication
P9301_18641	COG1372	Participates in initiation and elongation during chromosome replication
P9301_18641	COG0305	Participates in initiation and elongation during chromosome replication
P9301_18651	COG0445	tRNA wobble uridine modification
P9301_18701	COG1793	dna ligase
P9301_18721	COG0398	Pfam SNARE associated Golgi protein
P9301_18731	COG0525	valine-tRNA ligase activity
P9301_18751	COG3956	TIGRFAM MazG family protein
P9301_18761	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
P9301_18781	COG0404	The glycine cleavage system catalyzes the degradation of glycine
P9301_18791	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
P9301_18801	COG0504	CTP synthase activity
P9301_18811	COG0602	queuosine metabolic process
P9301_18821	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
P9301_18831	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P9301_18851	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
P9301_18871	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
P9301_18881	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P9301_18891	COG0170	dolichyl monophosphate biosynthetic process
P9301_18901	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P9301_18911	COG1049	propionate catabolic process, 2-methylcitrate cycle
P9301_18931	COG0788	formyltetrahydrofolate deformylase activity
P9301_18951	COG0443	Heat shock 70 kDa protein
P9301_18961	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
P9301_18971	COG0360	Binds together with S18 to 16S ribosomal RNA
P9301_18981	COG0137	argininosuccinate synthase activity
P9301_19001	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P9301_19011	COG0438	transferase activity, transferring glycosyl groups
P9301_19021	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
P9301_19031	COG0497	DNA recombination
P9301_19041	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P9301_19061	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
P9301_tRNALeuVIMSS1309171	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity