locus-tag	class	description
BMR99_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BMR99_00010	COG0477	Major facilitator Superfamily
BMR99_00020	COG0438	transferase activity, transferring glycosyl groups
BMR99_00030	COG1136	(ABC) transporter
BMR99_00030	COG0577	efflux transmembrane transporter activity
BMR99_00035	COG4591	ABC-type transport system involved in lipoprotein release permease component
BMR99_00040	COG0592	DNA-directed DNA polymerase activity
BMR99_00045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BMR99_00065	COG0187	DNA topoisomerase II activity
BMR99_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BMR99_00085	COG1355	regulation of microtubule-based process
BMR99_00100	COG3266	domain, Protein
BMR99_00130	COG0673	inositol 2-dehydrogenase activity
BMR99_00135	COG2814	Major facilitator Superfamily
BMR99_00150	COG0477	Major facilitator Superfamily
BMR99_00155	COG1473	amidohydrolase
BMR99_00160	COG1132	(ABC) transporter
BMR99_00165	COG1132	(ABC) transporter
BMR99_00170	COG0686	Belongs to the AlaDH PNT family
BMR99_00175	COG1113	amino acid transport
BMR99_00185	COG1254	Belongs to the acylphosphatase family
BMR99_00190	COG1739	Uncharacterized protein family UPF0029
BMR99_00225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BMR99_00240	COG1216	Glycosyl transferase, family 2
BMR99_00240	COG0438	transferase activity, transferring glycosyl groups
BMR99_00270	COG1088	dTDP-glucose 4,6-dehydratase activity
BMR99_00275	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BMR99_00275	COG5479	isomerase activity
BMR99_00290	COG1216	Glycosyl transferase, family 2
BMR99_00305	COG0463	Glycosyl transferase, family 2
BMR99_00340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BMR99_00365	COG1136	(ABC) transporter
BMR99_00370	COG1136	(ABC) transporter
BMR99_00370	COG0577	efflux transmembrane transporter activity
BMR99_00375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BMR99_00395	COG1022	Amp-dependent synthetase and ligase
BMR99_00400	COG2814	Major facilitator Superfamily
BMR99_00410	COG1609	Transcriptional regulator
BMR99_00415	COG1335	isochorismatase
BMR99_00435	COG0765	amino acid transport
BMR99_00455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BMR99_00460	COG0698	ribose 5-phosphate isomerase
BMR99_00480	COG2271	Major facilitator Superfamily
BMR99_00495	COG3618	amidohydrolase
BMR99_00500	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BMR99_00515	COG2376	Dihydroxyacetone kinase
BMR99_00520	COG0149	triose-phosphate isomerase activity
BMR99_00525	COG1349	DNA-binding transcription factor activity
BMR99_00530	COG4221	oxidoreductase activity
BMR99_00535	COG0698	ribose 5-phosphate isomerase
BMR99_00545	COG0647	UMP catabolic process
BMR99_00550	COG1069	ribulokinase activity
BMR99_00575	COG3409	Peptidoglycan-binding domain 1 protein
BMR99_00610	COG0676	glucose-6-phosphate 1-epimerase activity
BMR99_00630	COG0438	transferase activity, transferring glycosyl groups
BMR99_00635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BMR99_00645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BMR99_00655	COG2814	Major facilitator Superfamily
BMR99_00710	COG2860	membrane
BMR99_00760	COG2095	MarC family integral membrane protein
BMR99_00800	COG1737	Transcriptional regulator
BMR99_00805	COG2801	Transposase and inactivated derivatives
BMR99_00805	COG3415	Transposase
BMR99_00810	COG1960	acyl-CoA dehydrogenase activity
BMR99_00815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BMR99_00830	COG2271	Major facilitator Superfamily
BMR99_00835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BMR99_00840	COG2086	electron transfer activity
BMR99_00850	COG0644	oxidoreductase
BMR99_00870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BMR99_00875	COG0018	arginyl-trna synthetase
BMR99_00890	COG0673	inositol 2-dehydrogenase activity
BMR99_00895	COG2814	Major facilitator Superfamily
BMR99_00900	COG1120	ATPase activity
BMR99_00905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BMR99_00910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BMR99_00925	COG0471	metal ion transport
BMR99_00930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BMR99_00945	COG2271	Major facilitator Superfamily
BMR99_00955	COG1285	pathogenesis
BMR99_00960	COG2271	Major facilitator Superfamily
BMR99_00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BMR99_00985	COG0483	inositol monophosphate 1-phosphatase activity
BMR99_00995	COG0183	Belongs to the thiolase family
BMR99_01020	COG0783	Belongs to the Dps family
BMR99_01045	COG1914	H( )-stimulated, divalent metal cation uptake system
BMR99_01065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BMR99_01095	COG2226	methyltransferase
BMR99_01100	COG1902	pentaerythritol trinitrate reductase activity
BMR99_01105	COG0477	Major facilitator Superfamily
BMR99_01115	COG0305	Participates in initiation and elongation during chromosome replication
BMR99_01120	COG1937	Protein conserved in bacteria
BMR99_01150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BMR99_01215	COG0243	molybdopterin cofactor binding
BMR99_01220	COG0437	4 iron, 4 sulfur cluster binding
BMR99_01230	COG1111	helicase
BMR99_01230	COG1205	dead DEAH box helicase
BMR99_01235	COG2813	Specifically methylates the guanine in position
BMR99_01240	COG1754	DNA topoisomerase type I activity
BMR99_01240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BMR99_01250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BMR99_01255	COG0470	DNA polymerase III
BMR99_01265	COG1774	PSP1 C-terminal conserved region
BMR99_01275	COG1136	(ABC) transporter
BMR99_01285	COG1113	amino acid transport
BMR99_01315	COG0406	alpha-ribazole phosphatase activity
BMR99_01325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BMR99_01350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BMR99_01355	COG0302	gtp cyclohydrolase
BMR99_01360	COG1725	Transcriptional regulator
BMR99_01370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BMR99_01385	COG0542	response to heat
BMR99_01395	COG0710	3-dehydroquinate dehydratase activity
BMR99_01410	COG1122	ATPase activity
BMR99_01415	COG4721	ABC-type cobalt transport system, permease component
BMR99_01425	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BMR99_01430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BMR99_01440	COG1082	Xylose isomerase domain protein TIM barrel
BMR99_01450	COG3548	integral membrane protein
BMR99_01470	COG0406	alpha-ribazole phosphatase activity
BMR99_01480	COG1472	Belongs to the glycosyl hydrolase 3 family
BMR99_01495	COG0640	Transcriptional regulator
BMR99_01505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BMR99_01530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BMR99_01535	COG0456	acetyltransferase
BMR99_01560	COG0745	RESPONSE REGULATOR receiver
BMR99_01565	COG1490	D-aminoacyl-tRNA deacylase activity
BMR99_01570	COG3485	protocatechuate 3,4-dioxygenase
BMR99_01575	COG0354	folic acid binding
BMR99_01615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BMR99_01625	COG0590	tRNA wobble adenosine to inosine editing
BMR99_01640	COG3263	regulation of cellular component size
BMR99_01660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BMR99_01665	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BMR99_01670	COG2815	serine threonine protein kinase
BMR99_01670	COG0515	serine threonine protein kinase
BMR99_01675	COG2815	serine threonine protein kinase
BMR99_01675	COG0515	serine threonine protein kinase
BMR99_01680	COG0768	penicillin binding
BMR99_01695	COG1716	ATPase activity
BMR99_01700	COG1716	ATPase activity
BMR99_01705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BMR99_01735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BMR99_01745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BMR99_01755	COG0494	nUDIX hydrolase
BMR99_01780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BMR99_01815	COG2132	Multicopper oxidase
BMR99_01840	COG1012	belongs to the aldehyde dehydrogenase family
BMR99_01850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BMR99_01860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BMR99_01865	COG0542	response to heat
BMR99_01870	COG1297	OPT oligopeptide transporter protein
BMR99_01885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BMR99_01890	COG1704	LemA family
BMR99_01910	COG0191	fructose-bisphosphate aldolase activity
BMR99_01930	COG2814	Major facilitator Superfamily
BMR99_01940	COG3962	Belongs to the TPP enzyme family
BMR99_01945	COG3718	enzyme involved in inositol metabolism
BMR99_01965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BMR99_01970	COG0673	inositol 2-dehydrogenase activity
BMR99_01980	COG1082	Xylose isomerase domain protein TIM barrel
BMR99_01990	COG0129	dihydroxy-acid dehydratase activity
BMR99_02000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BMR99_02005	COG0181	hydroxymethylbilane synthase activity
BMR99_02010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BMR99_02015	COG0535	radical SAM domain protein
BMR99_02035	COG0477	Major facilitator Superfamily
BMR99_02080	COG0588	phosphoglycerate mutase activity
BMR99_02090	COG5002	protein histidine kinase activity
BMR99_02100	COG1329	Transcriptional regulator
BMR99_02105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BMR99_02110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BMR99_02115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BMR99_02120	COG0252	asparaginase activity
BMR99_02125	COG1113	amino acid transport
BMR99_02130	COG1113	amino acid transport
BMR99_02140	COG0215	cysteine-tRNA ligase activity
BMR99_02145	COG1802	Transcriptional regulator
BMR99_02150	COG1620	l-lactate permease
BMR99_02155	COG0247	lactate metabolic process
BMR99_02160	COG1139	Iron-sulfur cluster binding protein
BMR99_02165	COG1556	Lactate utilization protein
BMR99_02180	COG0626	cystathionine gamma-synthase activity
BMR99_02185	COG3842	ATPase activity
BMR99_02190	COG1760	l-serine dehydratase
BMR99_02205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BMR99_02220	COG2409	Drug exporters of the RND superfamily
BMR99_02230	COG1482	cell wall glycoprotein biosynthetic process
BMR99_02240	COG0459	protein refolding
BMR99_02260	COG1051	belongs to the nudix hydrolase family
BMR99_02270	COG3693	PFAM glycoside hydrolase, family 10
BMR99_02305	COG1278	Cold shock
BMR99_02320	COG2252	PERMEase
BMR99_02330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BMR99_02335	COG1321	iron dependent repressor
BMR99_02340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BMR99_02380	COG1970	mechanosensitive ion channel activity
BMR99_02430	COG3118	belongs to the thioredoxin family
BMR99_02440	COG0542	response to heat
BMR99_02465	COG1174	glycine betaine transport
BMR99_02470	COG1732	Glycine betaine
BMR99_02475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BMR99_02480	COG0459	protein refolding
BMR99_02490	COG0516	GMP reductase activity
BMR99_02495	COG0287	Prephenate dehydrogenase
BMR99_02495	COG1605	Chorismate mutase
BMR99_02520	COG1045	serine acetyltransferase
BMR99_02540	COG2160	L-arabinose isomerase activity
BMR99_02545	COG1609	Transcriptional regulator
BMR99_02570	COG0519	Catalyzes the synthesis of GMP from XMP
BMR99_02570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BMR99_02585	COG1983	PspC domain protein
BMR99_02595	COG2197	response regulator
BMR99_02600	COG2261	transglycosylase associated protein
BMR99_02625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BMR99_02645	COG0138	bifunctional purine biosynthesis protein purh
BMR99_02650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BMR99_02660	COG0039	L-malate dehydrogenase activity
BMR99_02680	COG1253	flavin adenine dinucleotide binding
BMR99_02710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BMR99_02715	COG2801	Transposase and inactivated derivatives
BMR99_02715	COG3415	Transposase
BMR99_02760	COG1063	alcohol dehydrogenase
BMR99_02785	COG4770	biotin carboxylase activity
BMR99_02805	COG0424	maF-like protein
BMR99_02815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BMR99_02830	COG3559	Exporter of polyketide antibiotics
BMR99_02835	COG1131	(ABC) transporter
BMR99_02855	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BMR99_02855	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BMR99_02885	COG1316	TRANSCRIPTIONal
BMR99_02930	COG2835	tetraacyldisaccharide 4'-kinase activity
BMR99_02965	COG4948	Mandelate Racemase Muconate Lactonizing
BMR99_02970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BMR99_02975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BMR99_02995	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BMR99_03005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BMR99_03015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BMR99_03020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BMR99_03025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BMR99_03030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BMR99_03040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BMR99_03080	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BMR99_03090	COG2241	protein methyltransferase activity
BMR99_03090	COG2242	protein methyltransferase activity
BMR99_03095	COG2099	Precorrin-6x reductase
BMR99_03135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BMR99_03140	COG2365	Tyrosine phosphatase family
BMR99_03145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BMR99_03150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BMR99_03160	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BMR99_03205	COG2376	Dihydroxyacetone kinase
BMR99_03210	COG1461	Dihydroxyacetone kinase
BMR99_03225	COG0339	signal peptide processing
BMR99_03230	COG0247	lactate metabolic process
BMR99_03230	COG0277	FAD linked oxidase domain protein
BMR99_03250	COG0351	phosphomethylpyrimidine kinase
BMR99_03255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BMR99_03265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BMR99_03275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BMR99_03280	COG1309	transcriptional regulator
BMR99_03305	COG2076	Multidrug Resistance protein
BMR99_03310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BMR99_03385	COG3723	Recombinational DNA repair protein, rece pathway
BMR99_03425	COG0629	single-stranded DNA binding
BMR99_03545	COG5412	phage tail tape measure protein
BMR99_03545	COG3953	SLT domain
BMR99_03625	COG0544	peptidyl-prolyl cis-trans isomerase activity
BMR99_03630	COG0628	permease
BMR99_03635	COG0628	permease
BMR99_03640	COG0740	serine-type endopeptidase activity
BMR99_03645	COG0740	serine-type endopeptidase activity
BMR99_03650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BMR99_03660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BMR99_03665	COG0205	6-phosphofructokinase activity
BMR99_03675	COG0525	valine-tRNA ligase activity
BMR99_03700	COG0285	dihydrofolate synthase activity
BMR99_03715	COG2801	Transposase and inactivated derivatives
BMR99_03730	COG0387	Pfam Sodium calcium exchanger
BMR99_03750	COG1530	ribonuclease E activity
BMR99_03755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BMR99_03760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BMR99_03770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BMR99_03780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BMR99_03790	COG0799	negative regulation of ribosome biogenesis
BMR99_03825	COG0495	leucyl-tRNA aminoacylation
BMR99_03830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BMR99_03835	COG0281	malic enzyme
BMR99_03840	COG1555	photosystem II stabilization
BMR99_03840	COG1596	polysaccharide export
BMR99_03860	COG0268	Binds directly to 16S ribosomal RNA
BMR99_03870	COG0481	GTPase activity
BMR99_03885	COG0483	inositol monophosphate 1-phosphatase activity
BMR99_03890	COG1420	regulation of RNA biosynthetic process
BMR99_03895	COG0484	heat shock protein binding
BMR99_03910	COG0343	queuine tRNA-ribosyltransferase activity
BMR99_03930	COG0477	Major facilitator Superfamily
BMR99_03940	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BMR99_03950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BMR99_03965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BMR99_03975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BMR99_03980	COG1381	Involved in DNA repair and RecF pathway recombination
BMR99_04000	COG4810	utilization protein
BMR99_04005	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BMR99_04040	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BMR99_04045	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BMR99_04050	COG4820	ethanolamine utilization protein (EutJ)
BMR99_04060	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BMR99_04070	COG1012	belongs to the aldehyde dehydrogenase family
BMR99_04085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BMR99_04090	COG1121	(ABC) transporter
BMR99_04095	COG0803	Belongs to the bacterial solute-binding protein 9 family
BMR99_04100	COG0423	glycine-tRNA ligase activity
BMR99_04110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BMR99_04115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BMR99_04130	COG1053	succinate dehydrogenase
BMR99_04140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BMR99_04145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BMR99_04150	COG0390	transport system, permease component
BMR99_04160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BMR99_04165	COG0561	phosphatase activity
BMR99_04175	COG0714	Associated with various cellular activities
BMR99_04190	COG2304	oxidoreductase activity
BMR99_04200	COG1073	alpha beta
BMR99_04210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BMR99_04215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BMR99_04220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BMR99_04240	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BMR99_04250	COG1132	(ABC) transporter
BMR99_04260	COG0531	amino acid
BMR99_04265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BMR99_04290	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BMR99_04295	COG2884	Cell division ATP-binding protein ftsE
BMR99_04305	COG0741	lytic transglycosylase activity
BMR99_04305	COG0739	heme binding
BMR99_04305	COG1196	nuclear chromosome segregation
BMR99_04315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BMR99_04330	COG1678	Uncharacterized ACR, COG1678
BMR99_04340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BMR99_04345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BMR99_04350	COG0653	protein targeting
BMR99_04380	COG0180	Tryptophanyl-tRNA synthetase
BMR99_04385	COG0513	Belongs to the DEAD box helicase family
BMR99_04405	COG1278	Cold shock
BMR99_04410	COG1074	ATP-dependent DNA helicase activity
BMR99_04415	COG0210	DNA helicase
BMR99_04430	COG1074	ATP-dependent DNA helicase activity
BMR99_04475	COG1615	UPF0182 protein
BMR99_04500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BMR99_04510	COG0747	negative chemotaxis
BMR99_04515	COG0601	transmembrane transport
BMR99_04525	COG0444	Belongs to the ABC transporter superfamily
BMR99_04530	COG4172	Belongs to the ABC transporter superfamily
BMR99_04535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BMR99_04570	COG0483	inositol monophosphate 1-phosphatase activity
BMR99_04580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BMR99_04585	COG2135	peptidase activity
BMR99_04590	COG1595	DNA-templated transcription, initiation
BMR99_04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
BMR99_04610	COG0567	Dehydrogenase, E1 component
BMR99_04645	COG0460	homoserine dehydrogenase
BMR99_04665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BMR99_04670	COG2890	protein-(glutamine-N5) methyltransferase activity
BMR99_04695	COG0356	it plays a direct role in the translocation of protons across the membrane
BMR99_04705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BMR99_04710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BMR99_04715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BMR99_04720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BMR99_04725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BMR99_04730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BMR99_04750	COG0596	Alpha beta hydrolase
BMR99_04760	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
BMR99_04795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BMR99_04805	COG0366	Alpha amylase catalytic
BMR99_04810	COG0366	Alpha amylase catalytic
BMR99_04835	COG0482	sulfurtransferase activity
BMR99_04855	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BMR99_04860	COG0154	amidase activity
BMR99_04865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BMR99_04870	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BMR99_04890	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BMR99_04895	COG0517	IMP dehydrogenase activity
BMR99_04900	COG0410	ABC transporter
BMR99_04905	COG0411	ABC transporter
BMR99_04915	COG0559	Belongs to the binding-protein-dependent transport system permease family
BMR99_04935	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BMR99_04955	COG1216	Glycosyl transferase, family 2
BMR99_04965	COG1522	sequence-specific DNA binding
BMR99_04970	COG2226	methyltransferase
BMR99_04975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BMR99_04980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BMR99_04985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BMR99_04990	COG0477	Major facilitator Superfamily
BMR99_04995	COG1854	S-ribosylhomocysteine lyase activity
BMR99_05005	COG0582	viral genome integration into host DNA
BMR99_05040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BMR99_05065	COG0697	spore germination
BMR99_05075	COG1309	transcriptional regulator
BMR99_05090	COG1160	GTP binding
BMR99_05095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BMR99_05105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BMR99_05110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BMR99_05120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BMR99_05130	COG0646	methionine synthase
BMR99_05130	COG1410	methionine synthase
BMR99_05140	COG3579	cysteine-type endopeptidase activity
BMR99_05145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BMR99_05155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BMR99_05165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BMR99_05170	COG1758	RNA polymerase activity
BMR99_05175	COG0194	GDP metabolic process
BMR99_05185	COG0284	orotidine-5'-phosphate decarboxylase activity
BMR99_05190	COG0167	dihydroorotate dehydrogenase activity
BMR99_05195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BMR99_05200	COG0505	Belongs to the CarA family
BMR99_05205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BMR99_05210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BMR99_05220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BMR99_05225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BMR99_05230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BMR99_05235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BMR99_05240	COG0039	L-malate dehydrogenase activity
BMR99_05250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BMR99_05265	COG0124	histidyl-tRNA synthetase
BMR99_05270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BMR99_05275	COG1196	nuclear chromosome segregation
BMR99_05280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BMR99_05285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BMR99_05290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BMR99_05295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BMR99_05300	COG1862	Preprotein translocase
BMR99_05305	COG2255	four-way junction helicase activity
BMR99_05310	COG0632	four-way junction helicase activity
BMR99_05315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BMR99_05320	COG0217	transcriptional regulatory protein
BMR99_05330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BMR99_05335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BMR99_05340	COG0131	Imidazoleglycerol-phosphate dehydratase
BMR99_05350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BMR99_05370	COG0587	DNA-directed DNA polymerase activity
BMR99_05385	COG0067	glutamate synthase
BMR99_05385	COG0070	glutamate synthase
BMR99_05385	COG0069	glutamate synthase activity
BMR99_05390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BMR99_05400	COG0133	tryptophan synthase activity
BMR99_05405	COG0134	indole-3-glycerol-phosphate synthase activity
BMR99_05410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BMR99_05415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BMR99_05425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMR99_05430	COG0406	alpha-ribazole phosphatase activity
BMR99_05440	COG4120	Belongs to the binding-protein-dependent transport system permease family
BMR99_05445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BMR99_05455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BMR99_05465	COG0009	L-threonylcarbamoyladenylate synthase
BMR99_05475	COG0205	6-phosphofructokinase activity
BMR99_05490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BMR99_05495	COG0358	DNA primase activity
BMR99_05500	COG0351	phosphomethylpyrimidine kinase
BMR99_05500	COG0352	thiamine-phosphate diphosphorylase activity
BMR99_05500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BMR99_05515	COG1397	ADP-ribosylglycohydrolase
BMR99_05535	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BMR99_05545	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BMR99_05550	COG1492	cobalamin metabolic process
BMR99_05560	COG1797	cobyrinic acid a,c-diamide synthase activity
BMR99_05570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BMR99_05580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BMR99_05590	COG1295	ribonuclease BN
BMR99_05595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BMR99_05595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BMR99_05615	COG1716	ATPase activity
BMR99_05620	COG0509	glycine decarboxylation via glycine cleavage system
BMR99_05645	COG0438	transferase activity, transferring glycosyl groups
BMR99_05665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BMR99_05695	COG2326	polyphosphate kinase activity
BMR99_05700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BMR99_05720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BMR99_05735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BMR99_05745	COG0435	Glutathione S-transferase
BMR99_05755	COG0456	acetyltransferase
BMR99_05755	COG0454	-acetyltransferase
BMR99_05770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BMR99_05775	COG0531	amino acid
BMR99_05780	COG0569	domain protein
BMR99_05830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BMR99_05835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BMR99_05850	COG0039	L-malate dehydrogenase activity
BMR99_05855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BMR99_05875	COG1946	Acyl-CoA thioesterase
BMR99_05880	COG1643	Atp-dependent helicase
BMR99_05885	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BMR99_05900	COG0247	lactate metabolic process
BMR99_05905	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BMR99_05910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BMR99_05915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BMR99_05915	COG1752	Esterase of the alpha-beta hydrolase superfamily
BMR99_05925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BMR99_05935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BMR99_05945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BMR99_05955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BMR99_05960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BMR99_05965	COG1126	abc transporter atp-binding protein
BMR99_05970	COG1418	mRNA catabolic process
BMR99_05975	COG2137	regulation of response to DNA damage stimulus
BMR99_05990	COG1201	RNA secondary structure unwinding
BMR99_05995	COG1396	sequence-specific DNA binding
BMR99_06000	COG1058	Belongs to the CinA family
BMR99_06000	COG1546	Belongs to the CinA family
BMR99_06010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BMR99_06015	COG1674	ftsk spoiiie
BMR99_06035	COG1181	Belongs to the D-alanine--D-alanine ligase family
BMR99_06040	COG0204	Acyl-transferase
BMR99_06050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BMR99_06055	COG1414	Transcriptional regulator
BMR99_06075	COG0179	Fumarylacetoacetate (FAA) hydrolase
BMR99_06080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BMR99_06085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BMR99_06090	COG0473	3-isopropylmalate dehydrogenase activity
BMR99_06110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BMR99_06120	COG0028	Belongs to the TPP enzyme family
BMR99_06130	COG0107	imidazoleglycerol-phosphate synthase activity
BMR99_06135	COG0667	Aldo Keto reductase
BMR99_06145	COG4581	dead DEAH box helicase
BMR99_06150	COG0561	phosphatase activity
BMR99_06170	COG0805	protein transport
BMR99_06190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMR99_06210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BMR99_06215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BMR99_06230	COG4974	Belongs to the 'phage' integrase family
BMR99_06245	COG0497	DNA recombination
BMR99_06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BMR99_06265	COG1122	ATPase activity
BMR99_06275	COG0647	UMP catabolic process
BMR99_06305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BMR99_06310	COG0165	Argininosuccinate lyase
BMR99_06315	COG1438	arginine binding
BMR99_06325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BMR99_06330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BMR99_06335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BMR99_06340	COG0436	Aminotransferase
BMR99_06345	COG0072	phenylalanine-tRNA ligase activity
BMR99_06345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BMR99_06350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BMR99_06355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BMR99_06360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BMR99_06365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BMR99_06370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BMR99_06380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BMR99_06385	COG0140	phosphoribosyl-ATP diphosphatase activity
BMR99_06390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BMR99_06395	COG0215	cysteine-tRNA ligase activity
BMR99_06400	COG0667	Aldo Keto reductase
BMR99_06435	COG1968	undecaprenyl-diphosphatase activity
BMR99_06445	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BMR99_06455	COG0606	chelatase, subunit chli
BMR99_06460	COG0792	nuclease activity
BMR99_06470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BMR99_06475	COG0681	Belongs to the peptidase S26 family
BMR99_06480	COG0335	large ribosomal subunit rRNA binding
BMR99_06485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BMR99_06490	COG1053	succinate dehydrogenase
BMR99_06505	COG0336	Belongs to the RNA methyltransferase TrmD family
BMR99_06510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BMR99_06515	COG1837	Belongs to the UPF0109 family
BMR99_06520	COG0228	four-way junction DNA binding
BMR99_06555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BMR99_06560	COG0571	ribonuclease III activity
BMR99_06570	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BMR99_06575	COG0742	ribosomal rna small subunit methyltransferase
BMR99_06590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BMR99_06595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BMR99_06610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BMR99_06615	COG1185	polyribonucleotide nucleotidyltransferase activity
BMR99_06620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BMR99_06625	COG0196	riboflavin kinase activity
BMR99_06630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BMR99_06635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BMR99_06640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BMR99_06645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BMR99_06650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BMR99_06665	COG0779	Required for maturation of 30S ribosomal subunits
BMR99_06675	COG0442	prolyl-tRNA aminoacylation
BMR99_06680	COG0454	-acetyltransferase
BMR99_06680	COG0456	acetyltransferase
BMR99_06685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BMR99_06690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BMR99_06695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BMR99_06700	COG0575	Belongs to the CDS family
BMR99_06705	COG0233	cytoplasmic translational termination
BMR99_06710	COG0528	UMP kinase activity
BMR99_06715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BMR99_06720	COG0052	Belongs to the universal ribosomal protein uS2 family
BMR99_06725	COG0741	lytic transglycosylase activity
BMR99_06725	COG1196	nuclear chromosome segregation
BMR99_06725	COG0739	heme binding
BMR99_06735	COG0242	peptide deformylase activity
BMR99_06760	COG1715	Restriction endonuclease
BMR99_06780	COG1119	ATPase activity
BMR99_06795	COG1028	Short-chain dehydrogenase reductase Sdr
BMR99_06805	COG2226	methyltransferase
BMR99_06810	COG0488	(ABC) transporter
BMR99_06815	COG2151	metal-sulfur cluster biosynthetic enzyme
BMR99_06825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BMR99_06830	COG0396	ATPase activity
BMR99_06845	COG0719	Fe-S assembly protein
BMR99_06855	COG1725	Transcriptional regulator
BMR99_06860	COG1131	(ABC) transporter
BMR99_06870	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BMR99_06880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BMR99_06895	COG0363	glucosamine-6-phosphate deaminase activity
BMR99_06905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BMR99_06910	COG0149	triose-phosphate isomerase activity
BMR99_06915	COG0126	phosphoglycerate kinase activity
BMR99_06920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BMR99_06940	COG1481	regulation of sporulation
BMR99_06950	COG1660	Displays ATPase and GTPase activities
BMR99_06955	COG0322	excinuclease ABC activity
BMR99_06960	COG4585	Histidine kinase
BMR99_06965	COG2197	response regulator
BMR99_06970	COG4152	abc transporter atp-binding protein
BMR99_06995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BMR99_07000	COG0861	Integral membrane protein TerC family
BMR99_07005	COG0556	nucleotide-excision repair
BMR99_07010	COG0237	dephospho-CoA kinase activity
BMR99_07020	COG0539	negative regulation of cytoplasmic translation
BMR99_07060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BMR99_07065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BMR99_07080	COG1799	cell septum assembly
BMR99_07090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BMR99_07100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BMR99_07105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BMR99_07110	COG0772	Belongs to the SEDS family
BMR99_07115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BMR99_07120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BMR99_07125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BMR99_07130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BMR99_07135	COG0768	penicillin binding
BMR99_07145	COG0275	rRNA processing
BMR99_07150	COG2001	Belongs to the MraZ family
BMR99_07160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BMR99_07165	COG0587	DNA-directed DNA polymerase activity
BMR99_07175	COG0210	DNA helicase
BMR99_07190	COG2815	serine threonine protein kinase
BMR99_07190	COG0515	serine threonine protein kinase
BMR99_07200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BMR99_07205	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BMR99_07220	COG1196	nuclear chromosome segregation
BMR99_07220	COG0741	lytic transglycosylase activity
BMR99_07220	COG0739	heme binding
BMR99_07235	COG0228	four-way junction DNA binding
BMR99_07260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BMR99_07305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BMR99_07310	COG0508	dehydrogenase complex catalyzes the overall conversion of
BMR99_07320	COG0488	(ABC) transporter
BMR99_07325	COG0174	glutamine synthetase
BMR99_07345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BMR99_07355	COG0174	glutamine synthetase
BMR99_07390	COG0006	proline dipeptidase activity
BMR99_07400	COG2301	Belongs to the HpcH HpaI aldolase family
BMR99_07420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BMR99_07425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BMR99_07435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BMR99_07440	COG0297	glycogen (starch) synthase activity
BMR99_07460	COG1611	Belongs to the LOG family
BMR99_07465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BMR99_07470	COG2171	N-acyltransferase activity
BMR99_07490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BMR99_07495	COG0114	fumarate hydratase activity
BMR99_07505	COG1027	Aspartate ammonia-lyase
BMR99_07510	COG1027	Aspartate ammonia-lyase
BMR99_07515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BMR99_07535	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BMR99_07540	COG1473	amidohydrolase
BMR99_07565	COG2807	transmembrane transport
BMR99_07570	COG1732	Glycine betaine
BMR99_07590	COG1929	Belongs to the glycerate kinase type-1 family
BMR99_07595	COG1966	Carbon starvation protein
BMR99_07610	COG2855	membrane
BMR99_07620	COG2022	thiamine diphosphate biosynthetic process
BMR99_07635	COG0352	thiamine-phosphate diphosphorylase activity
BMR99_07645	COG2855	membrane
BMR99_07655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BMR99_07680	COG0277	FAD linked oxidase domain protein
BMR99_07695	COG2826	transposase and inactivated derivatives, IS30 family
BMR99_07730	COG2814	Major facilitator Superfamily
BMR99_07735	COG0583	DNA-binding transcription factor activity
BMR99_07760	COG1196	nuclear chromosome segregation
BMR99_07760	COG0739	heme binding
BMR99_07760	COG0741	lytic transglycosylase activity
BMR99_07775	COG0012	GTP binding
BMR99_07780	COG1362	aminopeptidase activity
BMR99_07785	COG1322	Protein conserved in bacteria
BMR99_07790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BMR99_07795	COG1570	exodeoxyribonuclease VII activity
BMR99_07800	COG1722	exodeoxyribonuclease VII activity
BMR99_07810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BMR99_07820	COG1331	Highly conserved protein containing a thioredoxin domain
BMR99_07825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BMR99_07830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BMR99_07850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BMR99_07855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BMR99_07890	COG2094	Belongs to the DNA glycosylase MPG family
BMR99_07920	COG0531	amino acid
BMR99_07925	COG0148	phosphopyruvate hydratase activity
BMR99_07935	COG0477	Major facilitator Superfamily
BMR99_07960	COG0148	phosphopyruvate hydratase activity
BMR99_07985	COG0193	aminoacyl-tRNA hydrolase activity
BMR99_07990	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BMR99_07995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BMR99_08000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BMR99_08005	COG0540	Belongs to the ATCase OTCase family
BMR99_08025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BMR99_08030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BMR99_08035	COG0084	hydrolase, TatD family'
BMR99_08060	COG2233	PERMEase
BMR99_08070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BMR99_08080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BMR99_08085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BMR99_08095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BMR99_08100	COG0477	Major facilitator Superfamily
BMR99_08110	COG0477	Major facilitator Superfamily
BMR99_08120	COG0640	Transcriptional regulator
BMR99_08150	COG2197	response regulator
BMR99_08155	COG4585	Histidine kinase
BMR99_08180	COG0484	heat shock protein binding
BMR99_08185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BMR99_08195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BMR99_08210	COG2197	response regulator
BMR99_08245	COG3579	cysteine-type endopeptidase activity
BMR99_08250	COG0778	Nitroreductase
BMR99_08255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BMR99_08270	COG0802	atpase or kinase
BMR99_08275	COG0513	Belongs to the DEAD box helicase family
BMR99_08280	COG0438	transferase activity, transferring glycosyl groups
BMR99_08290	COG0736	holo-[acyl-carrier-protein] synthase activity
BMR99_08295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BMR99_08300	COG1072	(Pantothenic acid kinase))
BMR99_08305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BMR99_08310	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BMR99_08315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BMR99_08330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BMR99_08335	COG0101	tRNA pseudouridine synthase activity
BMR99_08340	COG2813	Specifically methylates the guanine in position
BMR99_08355	COG3845	ABC transporter
BMR99_08370	COG1131	(ABC) transporter
BMR99_08380	COG3583	domain protein
BMR99_08385	COG0438	transferase activity, transferring glycosyl groups
BMR99_08390	COG0203	ribosomal protein L17
BMR99_08395	COG0202	RNA polymerase activity
BMR99_08400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BMR99_08405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BMR99_08410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BMR99_08415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BMR99_08435	COG0563	adenylate kinase activity
BMR99_08475	COG0200	Binds to the 23S rRNA
BMR99_08485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BMR99_08490	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BMR99_08495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BMR99_08500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BMR99_08505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BMR99_08510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BMR99_08515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BMR99_08520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BMR99_08525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BMR99_08530	COG0255	Belongs to the universal ribosomal protein uL29 family
BMR99_08535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BMR99_08540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BMR99_08545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BMR99_08550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BMR99_08555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BMR99_08560	COG0089	rRNA binding
BMR99_08565	COG0088	Forms part of the polypeptide exit tunnel
BMR99_08570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BMR99_08575	COG0051	transcription antitermination factor activity, RNA binding
BMR99_08585	COG3415	Transposase
BMR99_08585	COG2801	Transposase and inactivated derivatives
BMR99_08590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMR99_08605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BMR99_08610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BMR99_08615	COG0049	tRNA binding
BMR99_08620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BMR99_08625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BMR99_08630	COG0085	RNA polymerase activity
BMR99_08640	COG0222	ribosome binding
BMR99_08645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BMR99_08650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BMR99_08655	COG0321	lipoyl(octanoyl) transferase activity
BMR99_08660	COG0081	regulation of translation
BMR99_08665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BMR99_08670	COG0250	Participates in transcription elongation, termination and antitermination
BMR99_08690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BMR99_08700	COG2030	dehydratase
BMR99_08705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BMR99_08720	COG3634	alkyl hydroperoxide reductase activity
BMR99_08725	COG0450	alkyl hydroperoxide reductase
BMR99_08755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BMR99_08755	COG0674	pyruvate-flavodoxin oxidoreductase activity
BMR99_08760	COG1013	pyruvate-flavodoxin oxidoreductase activity
BMR99_08765	COG3590	peptidase
BMR99_08785	COG1007	ATP synthesis coupled electron transport
BMR99_08800	COG0713	ATP synthesis coupled electron transport
BMR99_08805	COG0839	Belongs to the complex I subunit 6 family
BMR99_08810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMR99_08815	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BMR99_08820	COG1034	ATP synthesis coupled electron transport
BMR99_08825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BMR99_08835	COG0649	NAD binding
BMR99_08840	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMR99_08845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMR99_08855	COG0644	oxidoreductase
BMR99_08860	COG1169	isochorismate synthase
BMR99_08875	COG2226	methyltransferase
BMR99_08905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BMR99_08905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BMR99_08910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BMR99_08935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BMR99_08955	COG0436	Aminotransferase
BMR99_08965	COG0640	Transcriptional regulator
BMR99_08970	COG3415	Transposase
BMR99_08970	COG2801	Transposase and inactivated derivatives
BMR99_09000	COG1388	LysM domain
BMR99_09000	COG0791	NLP P60 protein
BMR99_09030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BMR99_09045	COG3830	Belongs to the UPF0237 family
BMR99_09070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BMR99_09075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BMR99_09085	COG0789	Transcriptional regulator
BMR99_09090	COG0484	heat shock protein binding
BMR99_09095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BMR99_09105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BMR99_09120	COG0310	cobalt ion transport
BMR99_09130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BMR99_09140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BMR99_09140	COG1648	precorrin-2 dehydrogenase activity
BMR99_09145	COG1643	Atp-dependent helicase
BMR99_09160	COG2910	NAD(P)H-binding
BMR99_09195	COG0028	Belongs to the TPP enzyme family
BMR99_09215	COG0840	transmembrane signaling receptor activity
BMR99_09220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BMR99_09225	COG0420	3'-5' exonuclease activity
BMR99_09230	COG0419	ATPase involved in DNA repair
BMR99_09250	COG0277	FAD linked oxidase domain protein
BMR99_09255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BMR99_09265	COG0166	Belongs to the GPI family
BMR99_09285	COG1881	PFAM PEBP family protein
BMR99_09340	COG2814	Major facilitator Superfamily
BMR99_09350	COG0047	phosphoribosylformylglycinamidine synthase activity
BMR99_09355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BMR99_09360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BMR99_09370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BMR99_09375	COG0151	Belongs to the GarS family
BMR99_09380	COG0569	domain protein
BMR99_09380	COG2985	domain, Protein
BMR99_09405	COG0531	amino acid
BMR99_09410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BMR99_09435	COG0673	inositol 2-dehydrogenase activity
BMR99_09440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BMR99_09450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BMR99_09455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BMR99_09530	COG1468	defense response to virus
BMR99_09530	COG1518	maintenance of DNA repeat elements
BMR99_09575	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BMR99_09630	COG1609	Transcriptional regulator
BMR99_09645	COG1113	amino acid transport
BMR99_09650	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BMR99_09655	COG0352	thiamine-phosphate diphosphorylase activity
BMR99_09670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BMR99_09675	COG1695	Transcriptional regulator
BMR99_09690	COG2011	ABC-type metal ion transport system permease component
BMR99_09695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BMR99_09700	COG1464	Belongs to the NlpA lipoprotein family
BMR99_09705	COG0745	RESPONSE REGULATOR receiver
BMR99_09710	COG2205	protein histidine kinase activity
BMR99_09725	COG0574	Belongs to the PEP-utilizing enzyme family
BMR99_09725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BMR99_09730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BMR99_09735	COG1715	Restriction endonuclease
BMR99_09745	COG2813	Specifically methylates the guanine in position
BMR99_09785	COG1028	Short-chain dehydrogenase reductase Sdr
BMR99_09795	COG0546	phosphoglycolate phosphatase activity
BMR99_09830	COG3409	Peptidoglycan-binding domain 1 protein
BMR99_09885	COG3896	Chloramphenicol phosphotransferase-like protein
BMR99_09890	COG2801	Transposase and inactivated derivatives
BMR99_09890	COG3415	Transposase
BMR99_09985	COG0358	DNA primase activity
BMR99_09985	COG0305	Participates in initiation and elongation during chromosome replication
BMR99_09990	COG2826	transposase and inactivated derivatives, IS30 family
BMR99_09995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BMR99_10000	COG2801	Transposase and inactivated derivatives
BMR99_10030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BMR99_10050	COG0471	metal ion transport
BMR99_10055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BMR99_10060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BMR99_10060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BMR99_10095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BMR99_10100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BMR99_10120	COG3842	ATPase activity
BMR99_10125	COG4208	sulfate ABC transporter
BMR99_10130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BMR99_10135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BMR99_10140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BMR99_10145	COG0175	sulfate reduction
BMR99_10160	COG0698	ribose 5-phosphate isomerase
BMR99_10175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BMR99_10180	COG1924	4 iron, 4 sulfur cluster binding
BMR99_10210	COG0314	molybdopterin synthase activity
BMR99_10220	COG0303	'Molybdopterin
BMR99_10225	COG0315	cyclic pyranopterin monophosphate synthase activity
BMR99_10230	COG0521	Mo-molybdopterin cofactor biosynthetic process
BMR99_10230	COG0315	cyclic pyranopterin monophosphate synthase activity
BMR99_10235	COG0537	adenosine 5'-monophosphoramidase activity
BMR99_10255	COG3409	Peptidoglycan-binding domain 1 protein
BMR99_10290	COG1126	abc transporter atp-binding protein
BMR99_10295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BMR99_10300	COG0765	amino acid transport
BMR99_10310	COG1063	alcohol dehydrogenase
BMR99_10315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BMR99_10335	COG4585	Histidine kinase
BMR99_10340	COG2197	response regulator
BMR99_10370	COG2826	transposase and inactivated derivatives, IS30 family
BMR99_10375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BMR99_10380	COG2801	Transposase and inactivated derivatives
BMR99_10390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BMR99_10395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BMR99_10425	COG0656	L-ascorbic acid biosynthetic process
BMR99_10450	COG0508	dehydrogenase complex catalyzes the overall conversion of
BMR99_10455	COG0022	dehydrogenase e1 component
BMR99_10465	COG0500	methyltransferase
BMR99_10470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BMR99_10475	COG0488	(ABC) transporter
BMR99_10490	COG1113	amino acid transport
BMR99_10495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BMR99_10515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BMR99_10515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMR99_10520	COG0702	epimerase
BMR99_10565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BMR99_10570	COG3177	Filamentation induced by cAMP protein fic
BMR99_10580	COG0582	viral genome integration into host DNA
BMR99_10610	COG1012	belongs to the aldehyde dehydrogenase family
BMR99_10615	COG0167	dihydroorotate dehydrogenase activity
BMR99_10620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BMR99_10620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BMR99_10620	COG1013	pyruvate-flavodoxin oxidoreductase activity
BMR99_10620	COG0674	pyruvate-flavodoxin oxidoreductase activity
BMR99_10645	COG2801	Transposase and inactivated derivatives
BMR99_10650	COG0477	Major facilitator Superfamily
BMR99_10655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BMR99_10660	COG4988	ABC transporter
BMR99_10665	COG1294	oxidase, subunit
BMR99_10670	COG1271	oxidase subunit
BMR99_10680	COG1072	(Pantothenic acid kinase))
BMR99_10710	COG4585	Histidine kinase
BMR99_10715	COG2197	response regulator
BMR99_10730	COG0656	L-ascorbic acid biosynthetic process
BMR99_10740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BMR99_10745	COG0584	glycerophosphoryl diester phosphodiesterase
BMR99_10750	COG4221	oxidoreductase activity
BMR99_10790	COG0604	alcohol dehydrogenase
BMR99_10795	COG0137	argininosuccinate synthase activity
BMR99_10800	COG1316	TRANSCRIPTIONal
BMR99_10805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BMR99_10810	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BMR99_10820	COG2205	protein histidine kinase activity
BMR99_10825	COG0745	RESPONSE REGULATOR receiver
BMR99_10845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BMR99_10865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BMR99_10865	COG0512	Glutamine amidotransferase of anthranilate synthase
BMR99_10870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BMR99_10875	COG0842	Transport permease protein
BMR99_10880	COG1131	(ABC) transporter
BMR99_10890	COG0732	type I restriction modification DNA specificity domain
BMR99_10955	COG1902	pentaerythritol trinitrate reductase activity
BMR99_10955	COG0446	pyridine nucleotide-disulphide oxidoreductase
BMR99_10965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BMR99_10970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BMR99_10995	COG1652	LysM domain
BMR99_11005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BMR99_11010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BMR99_11025	COG2801	Transposase and inactivated derivatives
BMR99_11075	COG1295	ribonuclease BN
BMR99_11100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BMR99_11105	COG1950	PFAM Membrane protein of
BMR99_11110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BMR99_11115	COG3340	Belongs to the peptidase S51 family
BMR99_11125	COG2205	protein histidine kinase activity
BMR99_11140	COG1349	DNA-binding transcription factor activity
BMR99_11145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BMR99_11150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BMR99_11155	COG0641	radical SAM
BMR99_11190	COG0673	inositol 2-dehydrogenase activity
BMR99_11195	COG1609	Transcriptional regulator
BMR99_11205	COG0076	glutamate decarboxylase activity
BMR99_11210	COG0531	amino acid
BMR99_11235	COG0517	IMP dehydrogenase activity
BMR99_11235	COG1125	glycine betaine transport
BMR99_11245	COG1174	glycine betaine transport
BMR99_11275	COG1175	transmembrane transport
BMR99_11290	COG2814	Major facilitator Superfamily
BMR99_11295	COG0359	binds to the 23S rRNA
BMR99_11300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BMR99_11310	COG0360	Binds together with S18 to 16S ribosomal RNA
BMR99_11350	COG0519	Catalyzes the synthesis of GMP from XMP
BMR99_11355	COG1690	Belongs to the RtcB family
BMR99_11375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BMR99_11420	COG0366	Alpha amylase catalytic
BMR99_11430	COG2233	PERMEase
BMR99_11445	COG0318	PFAM AMP-dependent synthetase and ligase
BMR99_11460	COG2837	iron assimilation
BMR99_11495	COG3588	fructose-bisphosphate aldolase
BMR99_11500	COG2353	YceI-like domain
BMR99_11510	COG0667	Aldo Keto reductase
BMR99_11525	COG2409	Drug exporters of the RND superfamily
BMR99_11550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BMR99_11555	COG4139	cobalamin transport
BMR99_11565	COG0668	transmembrane transport
BMR99_11605	COG3118	belongs to the thioredoxin family
BMR99_11620	COG1192	Involved in chromosome partitioning
BMR99_11630	COG0357	Ribosomal RNA small subunit methyltransferase G
BMR99_11640	COG0706	membrane insertase activity
BMR99_11645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BMR99_11650	COG0594	ribonuclease P activity