locus-tag	class	description
GCE56_00025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCE56_00075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GCE56_00090	COG2948	multi-organism process
GCE56_00105	COG3701	Conjugal transfer protein
GCE56_00130	COG3451	type IV secretory pathway VirB4
GCE56_00140	COG3838	Conjugal transfer protein Trbc
GCE56_00145	COG4962	Type ii secretion system protein e
GCE56_00165	COG3657	addiction module killer protein
GCE56_00380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCE56_00390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GCE56_00395	COG0187	DNA topoisomerase II activity
GCE56_00400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GCE56_00405	COG4106	trans-aconitate 2-methyltransferase activity
GCE56_00425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GCE56_00445	COG1561	YicC-like family, N-terminal region
GCE56_00450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GCE56_00455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GCE56_00460	COG1309	transcriptional regulator
GCE56_00465	COG0756	dUTP diphosphatase activity
GCE56_00470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GCE56_00475	COG2003	Belongs to the UPF0758 family
GCE56_00485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GCE56_00490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GCE56_00495	COG0438	transferase activity, transferring glycosyl groups
GCE56_00505	COG0438	transferase activity, transferring glycosyl groups
GCE56_00520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GCE56_00525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GCE56_00535	COG1519	Transferase
GCE56_00545	COG0438	transferase activity, transferring glycosyl groups
GCE56_00550	COG0859	PFAM glycosyl transferase family 9
GCE56_00565	COG0859	PFAM glycosyl transferase family 9
GCE56_00575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCE56_00580	COG0156	8-amino-7-oxononanoate synthase activity
GCE56_00585	COG1063	alcohol dehydrogenase
GCE56_00595	COG2861	carbohydrate metabolic process
GCE56_00600	COG4942	peptidase
GCE56_00605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCE56_00615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCE56_00620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GCE56_00630	COG1045	serine acetyltransferase
GCE56_00635	COG1045	serine acetyltransferase
GCE56_00640	COG1216	Glycosyl transferase, family 2
GCE56_00645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GCE56_00675	COG3475	LICD family
GCE56_00685	COG3955	Domain of unknown function (DUF1919)
GCE56_00695	COG2205	protein histidine kinase activity
GCE56_00700	COG0745	RESPONSE REGULATOR receiver
GCE56_00705	COG3678	ATP-independent chaperone mediated protein folding
GCE56_00720	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_00725	COG0205	6-phosphofructokinase activity
GCE56_00735	COG0149	triose-phosphate isomerase activity
GCE56_00745	COG3152	Membrane
GCE56_00750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCE56_00755	COG2814	Major facilitator Superfamily
GCE56_00760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GCE56_00770	COG3074	FtsZ-dependent cytokinesis
GCE56_00775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GCE56_00780	COG1575	Belongs to the MenA family. Type 1 subfamily
GCE56_00785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GCE56_00790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GCE56_00795	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GCE56_00800	COG1609	Transcriptional regulator
GCE56_00805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GCE56_00810	COG0254	rRNA binding
GCE56_00820	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GCE56_00825	COG0626	cystathionine gamma-synthase activity
GCE56_00830	COG0527	aspartate kinase activity
GCE56_00830	COG0460	homoserine dehydrogenase
GCE56_00835	COG2862	Uncharacterized protein family, UPF0114
GCE56_00845	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GCE56_00850	COG1216	Glycosyl transferase, family 2
GCE56_00860	COG0477	Major facilitator Superfamily
GCE56_00865	COG0583	DNA-binding transcription factor activity
GCE56_00885	COG0028	Belongs to the TPP enzyme family
GCE56_00890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCE56_00895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GCE56_00900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCE56_00905	COG0137	argininosuccinate synthase activity
GCE56_00910	COG0165	Argininosuccinate lyase
GCE56_00920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GCE56_00935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCE56_00940	COG4206	TonB-dependent receptor
GCE56_00945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GCE56_00980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GCE56_00990	COG1072	(Pantothenic acid kinase))
GCE56_01035	COG0051	transcription antitermination factor activity, RNA binding
GCE56_01040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GCE56_01045	COG0088	Forms part of the polypeptide exit tunnel
GCE56_01050	COG0089	rRNA binding
GCE56_01055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GCE56_01060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GCE56_01065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GCE56_01075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GCE56_01080	COG0255	Belongs to the universal ribosomal protein uL29 family
GCE56_01085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GCE56_01090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GCE56_01095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GCE56_01100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GCE56_01105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GCE56_01110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GCE56_01115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GCE56_01120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GCE56_01125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GCE56_01130	COG1841	ribosomal large subunit assembly
GCE56_01135	COG0200	Binds to the 23S rRNA
GCE56_01140	COG0201	protein transport
GCE56_01145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GCE56_01150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GCE56_01160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GCE56_01170	COG0203	ribosomal protein L17
GCE56_01175	COG0789	Transcriptional regulator
GCE56_01180	COG3036	rescue of stalled ribosome
GCE56_01185	COG1970	mechanosensitive ion channel activity
GCE56_01190	COG0569	domain protein
GCE56_01195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GCE56_01195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCE56_01200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GCE56_01205	COG0242	peptide deformylase activity
GCE56_01210	COG0758	DNA mediated transformation
GCE56_01215	COG0551	DNA topoisomerase type I activity
GCE56_01220	COG0009	L-threonylcarbamoyladenylate synthase
GCE56_01225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GCE56_01235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GCE56_01275	COG0583	DNA-binding transcription factor activity
GCE56_01280	COG3085	chromosome segregation
GCE56_01285	COG0606	chelatase, subunit chli
GCE56_01300	COG3978	acetolactate synthase activity
GCE56_01310	COG0129	dihydroxy-acid dehydratase activity
GCE56_01325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GCE56_01335	COG0675	Transposase, IS605 OrfB family
GCE56_01340	COG3041	Addiction module toxin RelE StbE family
GCE56_01350	COG0210	DNA helicase
GCE56_01355	COG0248	Ppx GppA phosphatase
GCE56_01360	COG0513	Belongs to the DEAD box helicase family
GCE56_01365	COG3118	belongs to the thioredoxin family
GCE56_01370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GCE56_01375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GCE56_01385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GCE56_01390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GCE56_01395	COG1088	dTDP-glucose 4,6-dehydratase activity
GCE56_01400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GCE56_01405	COG0456	acetyltransferase
GCE56_01410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GCE56_01415	COG2244	polysaccharide biosynthetic process
GCE56_01420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GCE56_01430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GCE56_01460	COG3071	HemY protein
GCE56_01465	COG2959	enzyme of heme biosynthesis
GCE56_01485	COG1965	Belongs to the frataxin family
GCE56_01490	COG5567	small periplasmic lipoprotein
GCE56_01495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GCE56_01510	COG1011	Hydrolase
GCE56_01515	COG0210	DNA helicase
GCE56_01525	COG2962	Rard protein
GCE56_01530	COG2050	protein possibly involved in aromatic compounds catabolism
GCE56_01545	COG2267	carboxylic ester hydrolase activity
GCE56_01550	COG0561	phosphatase activity
GCE56_01560	COG3188	usher protein
GCE56_01565	COG3121	Chaperone
GCE56_01570	COG3539	Fimbrial protein
GCE56_01580	COG1511	domain protein
GCE56_01580	COG3264	Mechanosensitive ion channel
GCE56_01585	COG0688	phosphatidylethanolamine metabolic process
GCE56_01590	COG1162	GTPase activity
GCE56_01595	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GCE56_01625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GCE56_01630	COG0802	atpase or kinase
GCE56_01635	COG0860	N-Acetylmuramoyl-L-alanine amidase
GCE56_01640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GCE56_01645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GCE56_01650	COG1923	regulation of RNA biosynthetic process
GCE56_01655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GCE56_01660	COG0330	HflC and HflK could
GCE56_01665	COG0330	HflC and HflK could
GCE56_01670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GCE56_01675	COG1959	2 iron, 2 sulfur cluster binding
GCE56_01680	COG0557	exoribonuclease II activity
GCE56_01685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCE56_01690	COG0360	Binds together with S18 to 16S ribosomal RNA
GCE56_01695	COG2965	DNA replication, synthesis of RNA primer
GCE56_01700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GCE56_01705	COG0359	binds to the 23S rRNA
GCE56_01710	COG3061	Opacity-associated protein A
GCE56_01715	COG0254	rRNA binding
GCE56_01720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GCE56_01725	COG3443	Belongs to the bacterial solute-binding protein 9 family
GCE56_01730	COG1012	belongs to the aldehyde dehydrogenase family
GCE56_01735	COG0545	Peptidyl-prolyl cis-trans isomerase
GCE56_01745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GCE56_01755	COG1253	flavin adenine dinucleotide binding
GCE56_01760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCE56_01765	COG0729	surface antigen
GCE56_01770	COG2911	Protein conserved in bacteria
GCE56_01775	COG2105	PFAM AIG2 family protein
GCE56_01795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GCE56_01800	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GCE56_01805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCE56_01810	COG1438	arginine binding
GCE56_01815	COG0039	L-malate dehydrogenase activity
GCE56_01820	COG3423	Transcriptional regulator
GCE56_01835	COG0142	geranyltranstransferase activity
GCE56_01840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GCE56_01845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GCE56_01850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GCE56_01855	COG2027	D-alanyl-D-alanine carboxypeptidase
GCE56_01865	COG1534	Rna-binding protein
GCE56_01870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GCE56_01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GCE56_01880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GCE56_01885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GCE56_01890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GCE56_01905	COG0779	Required for maturation of 30S ribosomal subunits
GCE56_01910	COG0195	Participates in both transcription termination and antitermination
GCE56_01915	COG3064	Membrane
GCE56_01915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GCE56_01920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GCE56_01925	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GCE56_01930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GCE56_01935	COG1185	polyribonucleotide nucleotidyltransferase activity
GCE56_01945	COG0513	Belongs to the DEAD box helicase family
GCE56_01950	COG2964	Protein conserved in bacteria
GCE56_01960	COG0251	oxidation-reduction process
GCE56_01965	COG2271	Major facilitator Superfamily
GCE56_01995	COG3275	phosphorelay sensor kinase activity
GCE56_02000	COG1566	PFAM secretion protein HlyD family protein
GCE56_02015	COG3539	Fimbrial protein
GCE56_02020	COG3121	Chaperone
GCE56_02025	COG3188	usher protein
GCE56_02030	COG3539	Fimbrial protein
GCE56_02035	COG3539	Fimbrial protein
GCE56_02040	COG3539	Fimbrial protein
GCE56_02045	COG0826	peptidase U32
GCE56_02050	COG0826	peptidase U32
GCE56_02055	COG3154	lipid carrier protein
GCE56_02060	COG3153	acetyltransferase
GCE56_02065	COG2827	Endonuclease containing a URI domain
GCE56_02075	COG3787	Belongs to the UPF0306 family
GCE56_02090	COG0602	queuosine metabolic process
GCE56_02095	COG1328	CTP reductase activity
GCE56_02105	COG0251	oxidation-reduction process
GCE56_02110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GCE56_02115	COG0540	Belongs to the ATCase OTCase family
GCE56_02125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GCE56_02135	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GCE56_02150	COG0456	acetyltransferase
GCE56_02155	COG0525	valine-tRNA ligase activity
GCE56_02160	COG2927	DNA polymerase III (CHI subunit)
GCE56_02165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCE56_02170	COG0795	lipopolysaccharide-transporting ATPase activity
GCE56_02175	COG0795	lipopolysaccharide-transporting ATPase activity
GCE56_02180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GCE56_02200	COG0675	Transposase, IS605 OrfB family
GCE56_02215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GCE56_02220	COG1690	Belongs to the RtcB family
GCE56_02225	COG1349	DNA-binding transcription factor activity
GCE56_02230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GCE56_02240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GCE56_02245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_02245	COG1263	PTS System
GCE56_02265	COG0028	Belongs to the TPP enzyme family
GCE56_02270	COG0440	acetolactate synthase activity
GCE56_02290	COG2252	PERMEase
GCE56_02295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCE56_02300	COG0025	NhaP-type Na H and K H
GCE56_02310	COG0583	DNA-binding transcription factor activity
GCE56_02315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GCE56_02325	COG3753	Protein conserved in bacteria
GCE56_02340	COG0586	Pfam SNARE associated Golgi protein
GCE56_02345	COG1322	Protein conserved in bacteria
GCE56_02350	COG2226	methyltransferase
GCE56_02355	COG3165	ubiquinone biosynthetic process from chorismate
GCE56_02365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCE56_02370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GCE56_02375	COG0805	protein transport
GCE56_02390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GCE56_02400	COG0183	Belongs to the thiolase family
GCE56_02405	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCE56_02405	COG1024	Enoyl-CoA hydratase
GCE56_02410	COG0006	proline dipeptidase activity
GCE56_02415	COG1739	Uncharacterized protein family UPF0029
GCE56_02420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GCE56_02455	COG1914	H( )-stimulated, divalent metal cation uptake system
GCE56_02460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GCE56_02465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GCE56_02470	COG4770	biotin carboxylase activity
GCE56_02475	COG0730	response to heat
GCE56_02490	COG0583	DNA-binding transcription factor activity
GCE56_02495	COG2197	response regulator
GCE56_02500	COG3850	Histidine kinase
GCE56_02505	COG2223	nitrite transmembrane transporter activity
GCE56_02510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GCE56_02515	COG1140	nitrate reductase beta subunit
GCE56_02520	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GCE56_02525	COG2181	nitrate reductase activity
GCE56_02530	COG1304	FMN binding
GCE56_02535	COG2194	sulfuric ester hydrolase activity
GCE56_02550	COG3604	Transcriptional regulator
GCE56_02555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCE56_02560	COG0375	protein maturation
GCE56_02565	COG0298	carbon dioxide binding
GCE56_02570	COG2076	Multidrug Resistance protein
GCE56_02575	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GCE56_02580	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GCE56_02585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GCE56_02590	COG1053	succinate dehydrogenase
GCE56_02595	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GCE56_02600	COG0584	glycerophosphoryl diester phosphodiesterase
GCE56_02610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GCE56_02620	COG0247	lactate metabolic process
GCE56_02630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GCE56_02640	COG0425	Belongs to the sulfur carrier protein TusA family
GCE56_02655	COG2217	Heavy metal translocating P-type atpase
GCE56_02660	COG3714	YhhN family
GCE56_02670	COG3776	membrane
GCE56_02675	COG0742	ribosomal rna small subunit methyltransferase
GCE56_02680	COG0552	protein localization to endoplasmic reticulum
GCE56_02685	COG2884	Cell division ATP-binding protein ftsE
GCE56_02690	COG2177	Part of the ABC transporter FtsEX involved in
GCE56_02700	COG1929	Belongs to the glycerate kinase type-1 family
GCE56_02710	COG2814	Major facilitator Superfamily
GCE56_02715	COG1846	Transcriptional regulator
GCE56_02720	COG0501	Belongs to the peptidase M48B family
GCE56_02725	COG3842	ATPase activity
GCE56_02730	COG0395	ABC-type sugar transport system, permease component
GCE56_02740	COG1653	transport
GCE56_02745	COG0584	glycerophosphoryl diester phosphodiesterase
GCE56_02750	COG2807	transmembrane transport
GCE56_02775	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GCE56_02780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCE56_02785	COG2264	protein methyltransferase activity
GCE56_02790	COG4145	pantothenate transmembrane transporter activity
GCE56_02795	COG3924	membrane
GCE56_02800	COG0439	Biotin carboxylase
GCE56_02805	COG0511	ligase activity, forming carbon-carbon bonds
GCE56_02810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GCE56_02815	COG0604	alcohol dehydrogenase
GCE56_02820	COG1077	Cell shape determining protein MreB Mrl
GCE56_02825	COG1792	Involved in formation and maintenance of cell shape
GCE56_02830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GCE56_02835	COG0424	maF-like protein
GCE56_02840	COG1530	ribonuclease E activity
GCE56_02845	COG3164	Protein of unknown function
GCE56_02850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCE56_02855	COG0312	modulator of DNA gyrase
GCE56_02865	COG2732	(Barnase) inhibitor
GCE56_02870	COG3028	Belongs to the UPF0307 family
GCE56_02875	COG0312	modulator of DNA gyrase
GCE56_02880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCE56_02885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCE56_02890	COG1660	Displays ATPase and GTPase activities
GCE56_02900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GCE56_02905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GCE56_02910	COG1137	ATPase activity
GCE56_02915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GCE56_02920	COG3117	lipopolysaccharide transmembrane transporter activity
GCE56_02925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GCE56_02930	COG0517	IMP dehydrogenase activity
GCE56_02930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GCE56_02935	COG0530	calcium, potassium:sodium antiporter activity
GCE56_02940	COG1127	ABC transporter
GCE56_02945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GCE56_02950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCE56_02955	COG2854	intermembrane phospholipid transfer
GCE56_02965	COG5007	Belongs to the BolA IbaG family
GCE56_02970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GCE56_02990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCE56_02995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GCE56_03000	COG3105	Protein conserved in bacteria
GCE56_03005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GCE56_03010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GCE56_03015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GCE56_03020	COG0625	glutathione transferase activity
GCE56_03025	COG2969	positive regulation of protein catabolic process
GCE56_03035	COG1473	amidohydrolase
GCE56_03040	COG3069	C4-dicarboxylate transmembrane transporter activity
GCE56_03045	COG0493	'glutamate synthase
GCE56_03050	COG0067	glutamate synthase
GCE56_03050	COG0069	glutamate synthase activity
GCE56_03050	COG0070	glutamate synthase
GCE56_03055	COG0784	Response regulator, receiver
GCE56_03055	COG5002	protein histidine kinase activity
GCE56_03055	COG2198	Histidine kinase
GCE56_03060	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GCE56_03065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GCE56_03070	COG2207	Transcriptional regulator
GCE56_03075	COG0829	nickel cation binding
GCE56_03080	COG0831	urea catabolic process
GCE56_03085	COG0832	Belongs to the urease beta subunit family
GCE56_03090	COG0804	urea catabolic process
GCE56_03095	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GCE56_03100	COG0830	nickel cation binding
GCE56_03105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GCE56_03110	COG2823	Periplasmic or secreted lipoprotein
GCE56_03115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCE56_03120	COG0792	nuclease activity
GCE56_03130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GCE56_03140	COG1741	Belongs to the pirin family
GCE56_03145	COG0583	DNA-binding transcription factor activity
GCE56_03150	COG2259	Doxx family
GCE56_03160	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
GCE56_03165	COG4575	ribosome binding
GCE56_03170	COG0586	Pfam SNARE associated Golgi protein
GCE56_03175	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GCE56_03180	COG0446	pyridine nucleotide-disulphide oxidoreductase
GCE56_03180	COG1902	pentaerythritol trinitrate reductase activity
GCE56_03190	COG0612	Peptidase, M16
GCE56_03195	COG4178	(ABC) transporter
GCE56_03200	COG4771	TonB-dependent receptor
GCE56_03210	COG1595	DNA-templated transcription, initiation
GCE56_03220	COG0675	Transposase, IS605 OrfB family
GCE56_03230	COG0488	(ABC) transporter
GCE56_03235	COG0741	lytic transglycosylase activity
GCE56_03240	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GCE56_03245	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GCE56_03250	COG0406	alpha-ribazole phosphatase activity
GCE56_03255	COG3708	Transcriptional regulator
GCE56_03255	COG2207	Transcriptional regulator
GCE56_03260	COG3045	CreA protein
GCE56_03265	COG0745	RESPONSE REGULATOR receiver
GCE56_03275	COG0083	homoserine kinase activity
GCE56_03290	COG3022	response to hydroperoxide
GCE56_03295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GCE56_03305	COG0521	Mo-molybdopterin cofactor biosynthetic process
GCE56_03310	COG0443	Heat shock 70 kDa protein
GCE56_03315	COG0484	heat shock protein binding
GCE56_03320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCE56_03325	COG0583	DNA-binding transcription factor activity
GCE56_03330	COG0268	Binds directly to 16S ribosomal RNA
GCE56_03340	COG0196	riboflavin kinase activity
GCE56_03345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GCE56_03350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GCE56_03355	COG1047	Peptidyl-prolyl cis-trans
GCE56_03360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GCE56_03365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GCE56_03385	COG1470	cell adhesion involved in biofilm formation
GCE56_03385	COG1388	LysM domain
GCE56_03395	COG1979	alcohol dehydrogenase
GCE56_03405	COG0626	cystathionine gamma-synthase activity
GCE56_03410	COG0811	peptide transport
GCE56_03415	COG0848	biopolymer transport protein
GCE56_03425	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GCE56_03430	COG0437	4 iron, 4 sulfur cluster binding
GCE56_03435	COG5557	Pfam Polysulphide reductase, NrfD
GCE56_03440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GCE56_03445	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GCE56_03450	COG1773	rubredoxin
GCE56_03455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GCE56_03460	COG0298	carbon dioxide binding
GCE56_03465	COG0409	Hydrogenase expression formation protein
GCE56_03470	COG0309	Hydrogenase expression formation protein (HypE)
GCE56_03475	COG2391	methyltransferase activity
GCE56_03480	COG0425	Belongs to the sulfur carrier protein TusA family
GCE56_03485	COG2974	May be involved in recombination
GCE56_03495	COG0737	Belongs to the 5'-nucleotidase family
GCE56_03500	COG3719	Belongs to the RNase T2 family
GCE56_03505	COG0737	Belongs to the 5'-nucleotidase family
GCE56_03520	COG0419	ATPase involved in DNA repair
GCE56_03525	COG0420	3'-5' exonuclease activity
GCE56_03535	COG5002	protein histidine kinase activity
GCE56_03540	COG1114	Component of the transport system for branched-chain amino acids
GCE56_03590	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GCE56_03595	COG0437	4 iron, 4 sulfur cluster binding
GCE56_03605	COG2414	aldehyde ferredoxin oxidoreductase
GCE56_03610	COG0437	4 iron, 4 sulfur cluster binding
GCE56_03620	COG0450	alkyl hydroperoxide reductase
GCE56_03625	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GCE56_03630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GCE56_03635	COG0343	queuine tRNA-ribosyltransferase activity
GCE56_03640	COG1862	Preprotein translocase
GCE56_03645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCE56_03650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GCE56_03655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GCE56_03660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCE56_03660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GCE56_03665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GCE56_03670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GCE56_03680	COG2824	Alkylphosphonate utilization operon protein PhnA
GCE56_03695	COG1609	Transcriptional regulator
GCE56_03700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCE56_03705	COG1879	ABC-type sugar transport system periplasmic component
GCE56_03710	COG1172	Belongs to the binding-protein-dependent transport system permease family
GCE56_03720	COG1869	D-ribose catabolic process
GCE56_03725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GCE56_03730	COG0142	geranyltranstransferase activity
GCE56_03740	COG0301	tRNA thio-modification
GCE56_03740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCE56_03750	COG0693	protein deglycase activity
GCE56_03755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GCE56_03760	COG1666	GTP binding
GCE56_03765	COG2814	Major facilitator Superfamily
GCE56_03770	COG0109	protoheme IX farnesyltransferase activity
GCE56_03775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GCE56_03780	COG1845	cytochrome c oxidase, subunit III
GCE56_03785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GCE56_03790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GCE56_03800	COG0513	Belongs to the DEAD box helicase family
GCE56_03805	COG2223	nitrite transmembrane transporter activity
GCE56_03810	COG3056	Lipoprotein
GCE56_03815	COG0271	Belongs to the BolA IbaG family
GCE56_03820	COG0544	peptidyl-prolyl cis-trans isomerase activity
GCE56_03825	COG0740	serine-type endopeptidase activity
GCE56_03830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GCE56_03835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GCE56_03840	COG0776	regulation of translation
GCE56_03845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCE56_03850	COG1596	polysaccharide export
GCE56_03850	COG1555	photosystem II stabilization
GCE56_03855	COG0824	Thioesterase
GCE56_03860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GCE56_03865	COG1522	sequence-specific DNA binding
GCE56_03870	COG1132	(ABC) transporter
GCE56_03875	COG1132	(ABC) transporter
GCE56_03880	COG0347	Belongs to the P(II) protein family
GCE56_03885	COG0004	ammonium transporteR
GCE56_03890	COG1946	Acyl-CoA thioesterase
GCE56_03910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCE56_03915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCE56_03920	COG1309	transcriptional regulator
GCE56_03925	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GCE56_03930	COG1196	nuclear chromosome segregation
GCE56_03930	COG3264	Mechanosensitive ion channel
GCE56_03945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GCE56_03955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GCE56_03960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GCE56_03965	COG1966	Carbon starvation protein
GCE56_03970	COG2879	small protein
GCE56_03975	COG0523	cobalamin synthesis protein
GCE56_03985	COG3069	C4-dicarboxylate transmembrane transporter activity
GCE56_03990	COG2195	Cleaves the N-terminal amino acid of tripeptides
GCE56_04000	COG0534	Mate efflux family protein
GCE56_04005	COG0673	inositol 2-dehydrogenase activity
GCE56_04010	COG5564	TIM-barrel signal transduction protein
GCE56_04015	COG5441	Belongs to the UPF0261 family
GCE56_04050	COG2132	Multicopper oxidase
GCE56_04060	COG0288	reversible hydration of carbon dioxide
GCE56_04065	COG1131	(ABC) transporter
GCE56_04075	COG0477	Major facilitator Superfamily
GCE56_04095	COG0675	Transposase, IS605 OrfB family
GCE56_04105	COG2837	iron assimilation
GCE56_04120	COG4633	Protein conserved in bacteria
GCE56_04130	COG2963	transposase activity
GCE56_04155	COG0754	glutathionylspermidine amidase activity
GCE56_04160	COG0583	DNA-binding transcription factor activity
GCE56_04165	COG2610	gluconate transmembrane transporter activity
GCE56_04170	COG3048	D-serine ammonia-lyase activity
GCE56_04175	COG3842	ATPase activity
GCE56_04185	COG1840	ABC-type Fe3 transport system, periplasmic component
GCE56_04190	COG2271	Major facilitator Superfamily
GCE56_04195	COG3851	Histidine kinase
GCE56_04205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GCE56_04210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GCE56_04215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GCE56_04220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GCE56_04240	COG1489	DNA binding
GCE56_04245	COG1643	Atp-dependent helicase
GCE56_04250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GCE56_04255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GCE56_04260	COG0316	Belongs to the HesB IscA family
GCE56_04270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCE56_04280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCE56_04285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCE56_04290	COG3956	TIGRFAM MazG family protein
GCE56_04300	COG0504	CTP synthase activity
GCE56_04305	COG0148	phosphopyruvate hydratase activity
GCE56_04310	COG0471	metal ion transport
GCE56_04315	COG3961	Belongs to the TPP enzyme family
GCE56_04320	COG0741	lytic transglycosylase activity
GCE56_04320	COG1388	LysM domain
GCE56_04325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCE56_04330	COG2226	methyltransferase
GCE56_04335	COG0328	RNA-DNA hybrid ribonuclease activity
GCE56_04340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCE56_04350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCE56_04355	COG1120	ATPase activity
GCE56_04365	COG4264	IucA IucC family
GCE56_04375	COG0019	diaminopimelate decarboxylase activity
GCE56_04380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GCE56_04385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GCE56_04390	COG2814	Major facilitator Superfamily
GCE56_04405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GCE56_04410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GCE56_04415	COG0126	phosphoglycerate kinase activity
GCE56_04425	COG2314	TM2 domain
GCE56_04430	COG3104	oligopeptide transport
GCE56_04445	COG1846	Transcriptional regulator
GCE56_04450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GCE56_04465	COG1234	tRNA 3'-trailer cleavage
GCE56_04470	COG3539	Fimbrial protein
GCE56_04475	COG3188	usher protein
GCE56_04480	COG3121	Chaperone
GCE56_04485	COG3539	Fimbrial protein
GCE56_04490	COG3539	Fimbrial protein
GCE56_04510	COG0582	viral genome integration into host DNA
GCE56_04515	COG3539	Fimbrial protein
GCE56_04525	COG3188	usher protein
GCE56_04545	COG3539	Fimbrial protein
GCE56_04560	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GCE56_04570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCE56_04575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GCE56_04630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCE56_04635	COG1554	hydrolase, family 65, central catalytic
GCE56_04640	COG1263	PTS System
GCE56_04640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_04655	COG2207	Transcriptional regulator
GCE56_04655	COG3708	Transcriptional regulator
GCE56_04680	COG2274	protein secretion by the type I secretion system
GCE56_04690	COG1309	transcriptional regulator
GCE56_04695	COG0531	amino acid
GCE56_04700	COG1982	Orn Lys Arg decarboxylase major
GCE56_04765	COG2801	Transposase and inactivated derivatives
GCE56_04775	COG0741	lytic transglycosylase activity
GCE56_04780	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GCE56_04785	COG1194	a g-specific adenine glycosylase
GCE56_04795	COG3171	Protein conserved in bacteria
GCE56_04800	COG2066	Belongs to the glutaminase family
GCE56_04810	COG4607	ABC-type enterochelin transport system periplasmic component
GCE56_04815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GCE56_04820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GCE56_04825	COG0762	integral membrane protein
GCE56_04830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GCE56_04835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GCE56_04840	COG2805	Type II/IV secretion system protein
GCE56_04845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GCE56_04850	COG1678	Uncharacterized ACR, COG1678
GCE56_04855	COG0189	ligase activity
GCE56_04860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GCE56_04880	COG0583	DNA-binding transcription factor activity
GCE56_04885	COG0583	DNA-binding transcription factor activity
GCE56_04895	COG1960	acyl-CoA dehydrogenase activity
GCE56_04900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GCE56_04905	COG0121	glutamine amidotransferase
GCE56_04910	COG3034	peptidoglycan biosynthetic process
GCE56_04915	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCE56_04920	COG1805	sodium ion transport
GCE56_04925	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCE56_04930	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCE56_04935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GCE56_04940	COG2871	sodium ion transport
GCE56_04945	COG1477	protein flavinylation
GCE56_04950	COG2991	Protein conserved in bacteria
GCE56_04955	COG3237	CsbD-like
GCE56_04965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GCE56_04970	COG4774	siderophore transport
GCE56_04975	COG2195	Cleaves the N-terminal amino acid of tripeptides
GCE56_04980	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GCE56_04995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GCE56_05000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GCE56_05005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GCE56_05010	COG0318	PFAM AMP-dependent synthetase and ligase
GCE56_05010	COG0204	Acyl-transferase
GCE56_05015	COG2814	Major facilitator Superfamily
GCE56_05020	COG1546	Belongs to the CinA family
GCE56_05025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GCE56_05030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GCE56_05035	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GCE56_05065	COG2918	glutathione biosynthetic process
GCE56_05070	COG1854	S-ribosylhomocysteine lyase activity
GCE56_05075	COG4536	flavin adenine dinucleotide binding
GCE56_05080	COG4137	Cytochrome C assembly protein
GCE56_05085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GCE56_05090	COG0228	four-way junction DNA binding
GCE56_05100	COG0336	Belongs to the RNA methyltransferase TrmD family
GCE56_05105	COG0335	large ribosomal subunit rRNA binding
GCE56_05110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCE56_05115	COG0287	Prephenate dehydrogenase
GCE56_05115	COG1605	Chorismate mutase
GCE56_05120	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GCE56_05125	COG0077	Prephenate dehydratase
GCE56_05125	COG1605	Chorismate mutase
GCE56_05130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GCE56_05135	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCE56_05140	COG0564	pseudouridine synthase activity
GCE56_05150	COG0542	response to heat
GCE56_05180	COG5544	Lipoprotein
GCE56_05185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCE56_05190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCE56_05190	COG1042	CoA-binding domain protein
GCE56_05190	COG0045	succinate-CoA ligase (ADP-forming) activity
GCE56_05200	COG5160	protein modification by small protein removal
GCE56_05205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCE56_05210	COG2814	Major facilitator Superfamily
GCE56_05215	COG1566	PFAM secretion protein HlyD family protein
GCE56_05230	COG1335	isochorismatase
GCE56_05235	COG1846	Transcriptional regulator
GCE56_05240	COG2814	Major facilitator Superfamily
GCE56_05245	COG1629	transport
GCE56_05250	COG2113	Glycine betaine
GCE56_05255	COG4176	ABC-type proline glycine betaine transport system permease component
GCE56_05260	COG4175	Glycine betaine
GCE56_05275	COG1780	Probably involved in ribonucleotide reductase function
GCE56_05285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GCE56_05295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GCE56_05300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GCE56_05305	COG0321	lipoyl(octanoyl) transferase activity
GCE56_05315	COG1686	Belongs to the peptidase S11 family
GCE56_05320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GCE56_05325	COG0772	Belongs to the SEDS family
GCE56_05330	COG0768	penicillin binding
GCE56_05335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GCE56_05340	COG0799	negative regulation of ribosome biogenesis
GCE56_05350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GCE56_05355	COG1466	dna polymerase III delta subunit
GCE56_05360	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GCE56_05365	COG0495	leucyl-tRNA aminoacylation
GCE56_05370	COG1126	abc transporter atp-binding protein
GCE56_05375	COG0765	amino acid transport
GCE56_05380	COG0765	amino acid transport
GCE56_05405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GCE56_05415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GCE56_05425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GCE56_05430	COG1702	phosphate starvation-inducible protein PhoH
GCE56_05435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GCE56_05440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCE56_05445	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GCE56_05495	COG1940	carbohydrate kinase activity
GCE56_05495	COG1846	Transcriptional regulator
GCE56_05500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GCE56_05505	COG0363	glucosamine-6-phosphate deaminase activity
GCE56_05515	COG0582	viral genome integration into host DNA
GCE56_05555	COG3723	Recombinational DNA repair protein, rece pathway
GCE56_05560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCE56_05620	COG0305	Participates in initiation and elongation during chromosome replication
GCE56_05645	COG3477	response to acidic pH
GCE56_05660	COG3772	lysozyme
GCE56_05890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCE56_05905	COG0735	belongs to the Fur family
GCE56_05910	COG0716	FMN binding
GCE56_05920	COG0596	Alpha beta hydrolase
GCE56_05925	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GCE56_05930	COG0033	Phosphoglucomutase
GCE56_05935	COG4807	Protein conserved in bacteria
GCE56_05940	COG3609	addiction module antidote protein, CC2985 family
GCE56_05955	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GCE56_05970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GCE56_05980	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GCE56_05985	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GCE56_05990	COG0714	Associated with various cellular activities
GCE56_06000	COG2814	Major facilitator Superfamily
GCE56_06020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GCE56_06025	COG1053	succinate dehydrogenase
GCE56_06035	COG0567	Dehydrogenase, E1 component
GCE56_06040	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCE56_06045	COG0045	succinate-CoA ligase (ADP-forming) activity
GCE56_06050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GCE56_06055	COG1271	oxidase subunit
GCE56_06060	COG1294	oxidase, subunit
GCE56_06065	COG4890	Cyd operon protein YbgT
GCE56_06070	COG3790	cyd operon protein YbgE
GCE56_06075	COG0583	DNA-binding transcription factor activity
GCE56_06080	COG0477	Major facilitator Superfamily
GCE56_06090	COG0824	Thioesterase
GCE56_06095	COG0811	peptide transport
GCE56_06100	COG0848	biopolymer transport protein
GCE56_06105	COG3064	Membrane
GCE56_06110	COG0823	Involved in the tonB-independent uptake of proteins
GCE56_06115	COG2885	chlorophyll binding
GCE56_06120	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GCE56_06145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCE56_06150	COG0588	phosphoglycerate mutase activity
GCE56_06155	COG1119	ATPase activity
GCE56_06160	COG2831	hemolysin activation secretion protein
GCE56_06190	COG3585	molybdate ion transport
GCE56_06190	COG2005	Transcriptional regulator
GCE56_06200	COG0725	ABC transporter, periplasmic molybdate-binding protein
GCE56_06205	COG4149	molybdate abc transporter
GCE56_06210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GCE56_06215	COG0561	phosphatase activity
GCE56_06220	COG2706	6-phosphogluconolactonase activity
GCE56_06230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GCE56_06235	COG0156	8-amino-7-oxononanoate synthase activity
GCE56_06240	COG2226	methyltransferase
GCE56_06250	COG0556	nucleotide-excision repair
GCE56_06260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GCE56_06265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GCE56_06270	COG0315	cyclic pyranopterin monophosphate synthase activity
GCE56_06275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GCE56_06280	COG0314	molybdopterin synthase activity
GCE56_06285	COG0670	Belongs to the BI1 family
GCE56_06290	COG0842	Transport permease protein
GCE56_06295	COG0842	Transport permease protein
GCE56_06300	COG1131	(ABC) transporter
GCE56_06310	COG1309	transcriptional regulator
GCE56_06315	COG0513	Belongs to the DEAD box helicase family
GCE56_06320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCE56_06330	COG2897	thiosulfate sulfurtransferase activity
GCE56_06340	COG3069	C4-dicarboxylate transmembrane transporter activity
GCE56_06355	COG2079	MmgE PrpD family protein
GCE56_06360	COG0583	DNA-binding transcription factor activity
GCE56_06395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCE56_06405	COG0477	Major facilitator Superfamily
GCE56_06410	COG0302	gtp cyclohydrolase
GCE56_06415	COG2311	Membrane
GCE56_06420	COG2949	membrane
GCE56_06425	COG0281	malic enzyme
GCE56_06430	COG0295	cytidine deaminase activity
GCE56_06435	COG1346	cytolysis
GCE56_06440	COG1380	Effector of murein hydrolase LrgA
GCE56_06445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCE56_06445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCE56_06450	COG0489	protein tyrosine kinase activity
GCE56_06455	COG0572	uridine kinase
GCE56_06460	COG0717	Belongs to the dCTP deaminase family
GCE56_06465	COG2982	Protein involved in outer membrane biogenesis
GCE56_06470	COG3069	C4-dicarboxylate transmembrane transporter activity
GCE56_06475	COG1253	flavin adenine dinucleotide binding
GCE56_06485	COG0675	Transposase, IS605 OrfB family
GCE56_06490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GCE56_06685	COG4626	Terminase
GCE56_06685	COG1802	Transcriptional regulator
GCE56_06785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GCE56_06790	COG1454	alcohol dehydrogenase
GCE56_06795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GCE56_06795	COG0140	phosphoribosyl-ATP diphosphatase activity
GCE56_06800	COG0107	imidazoleglycerol-phosphate synthase activity
GCE56_06805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GCE56_06810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GCE56_06815	COG0131	Imidazoleglycerol-phosphate dehydratase
GCE56_06815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GCE56_06825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GCE56_06830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GCE56_06840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCE56_06845	COG0625	glutathione transferase activity
GCE56_06850	COG1686	Belongs to the peptidase S11 family
GCE56_06855	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GCE56_06860	COG1760	l-serine dehydratase
GCE56_06865	COG0814	amino acid
GCE56_06870	COG0671	phosphoesterase, PA-phosphatase related
GCE56_06875	COG0432	Pfam Uncharacterised protein family UPF0047
GCE56_06880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GCE56_06895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GCE56_06900	COG4160	amino acid transport
GCE56_06905	COG4215	(ABC) transporter
GCE56_06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCE56_06915	COG1126	abc transporter atp-binding protein
GCE56_06920	COG0702	epimerase
GCE56_06925	COG2431	L-lysine efflux transmembrane transporter activity
GCE56_06930	COG3593	DNA synthesis involved in DNA repair
GCE56_06935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCE56_06940	COG0577	efflux transmembrane transporter activity
GCE56_06940	COG1136	(ABC) transporter
GCE56_06945	COG1278	Cold shock
GCE56_06950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GCE56_06955	COG0542	response to heat
GCE56_06960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GCE56_06965	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GCE56_06970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GCE56_06980	COG0492	ferredoxin-NADP+ reductase activity
GCE56_06990	COG1674	ftsk spoiiie
GCE56_06990	COG3107	peptidoglycan biosynthetic process
GCE56_06995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GCE56_07000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GCE56_07005	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GCE56_07015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GCE56_07025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCE56_07030	COG1882	Formate acetyltransferase
GCE56_07035	COG2116	formate transmembrane transporter activity
GCE56_07040	COG1944	ATP diphosphatase activity
GCE56_07045	COG0252	asparaginase activity
GCE56_07060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GCE56_07065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GCE56_07070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GCE56_07075	COG0539	negative regulation of cytoplasmic translation
GCE56_07080	COG0776	regulation of translation
GCE56_07090	COG2333	competence protein COMEC
GCE56_07090	COG0658	competence protein
GCE56_07095	COG1132	(ABC) transporter
GCE56_07100	COG1663	tetraacyldisaccharide 4'-kinase activity
GCE56_07110	COG2835	tetraacyldisaccharide 4'-kinase activity
GCE56_07115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GCE56_07120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GCE56_07125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCE56_07130	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GCE56_07135	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GCE56_07140	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GCE56_07150	COG3700	Belongs to the class B bacterial acid phosphatase family
GCE56_07155	COG2989	Protein conserved in bacteria
GCE56_07160	COG3108	Peptidase M15
GCE56_07165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GCE56_07170	COG3157	Type VI secretion system effector, Hcp
GCE56_07260	COG3501	Rhs element vgr protein
GCE56_07325	COG3209	COG3209 Rhs family protein
GCE56_07385	COG1448	Aminotransferase
GCE56_07390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GCE56_07395	COG0017	Asparaginyl-tRNA synthetase
GCE56_07405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GCE56_07410	COG0308	aminopeptidase N
GCE56_07420	COG0167	dihydroorotate dehydrogenase activity
GCE56_07430	COG3217	Mosc domain protein beta barrel domain protein
GCE56_07430	COG0633	Ferredoxin
GCE56_07435	COG0116	Belongs to the methyltransferase superfamily
GCE56_07435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GCE56_07440	COG0488	(ABC) transporter
GCE56_07445	COG2995	paraquat-inducible protein a
GCE56_07450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GCE56_07450	COG3008	intermembrane lipid transfer
GCE56_07455	COG3009	Protein conserved in bacteria
GCE56_07465	COG3130	regulation of translation
GCE56_07470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCE56_07475	COG1067	ATP-dependent peptidase activity
GCE56_07480	COG3120	sequence-specific DNA binding
GCE56_07485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GCE56_07485	COG2885	chlorophyll binding
GCE56_07495	COG3070	regulator of competence-specific genes
GCE56_07500	COG1289	transmembrane transporter activity
GCE56_07505	COG0210	DNA helicase
GCE56_07510	COG1803	Methylglyoxal synthase
GCE56_07515	COG1832	CoA-binding protein
GCE56_07520	COG3785	DNA binding
GCE56_07525	COG1254	Belongs to the acylphosphatase family
GCE56_07530	COG2920	part of a sulfur-relay system
GCE56_07540	COG0456	acetyltransferase
GCE56_07550	COG3615	Tellurite resistance protein tehB
GCE56_07565	COG0583	DNA-binding transcription factor activity
GCE56_07570	COG0656	L-ascorbic acid biosynthetic process
GCE56_07580	COG3708	Transcriptional regulator
GCE56_07580	COG2207	Transcriptional regulator
GCE56_07595	COG1278	Cold shock
GCE56_07600	COG1560	Kdo2-lipid A biosynthetic process
GCE56_07615	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GCE56_07680	COG3083	sulfuric ester hydrolase activity
GCE56_07685	COG3082	Protein of unknown function (DUF1414)
GCE56_07690	COG3081	Nucleoid-associated protein
GCE56_07695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GCE56_07700	COG1061	Type III restriction enzyme res subunit
GCE56_07705	COG1187	pseudouridine synthase activity
GCE56_07710	COG2814	Major facilitator Superfamily
GCE56_07720	COG0791	NLP P60 protein
GCE56_07725	COG0671	phosphoesterase, PA-phosphatase related
GCE56_07740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GCE56_07750	COG0494	nUDIX hydrolase
GCE56_07755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GCE56_07760	COG2855	membrane
GCE56_07765	COG0583	DNA-binding transcription factor activity
GCE56_07770	COG0833	amino acid
GCE56_07780	COG4771	TonB-dependent receptor
GCE56_07790	COG0531	amino acid
GCE56_07800	COG3961	Belongs to the TPP enzyme family
GCE56_07805	COG0583	DNA-binding transcription factor activity
GCE56_07810	COG0277	FAD linked oxidase domain protein
GCE56_07815	COG2925	Exonuclease
GCE56_07820	COG2211	Major facilitator Superfamily
GCE56_07825	COG2926	Belongs to the UPF0265 family
GCE56_07830	COG1530	ribonuclease E activity
GCE56_07835	COG0564	pseudouridine synthase activity
GCE56_07845	COG0424	maF-like protein
GCE56_07850	COG1399	metal-binding, possibly nucleic acid-binding protein
GCE56_07855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GCE56_07860	COG0416	fatty acid biosynthetic process
GCE56_07865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GCE56_07880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCE56_07885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCE56_07890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GCE56_07895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GCE56_07900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GCE56_07905	COG0470	DNA polymerase III
GCE56_07910	COG0084	hydrolase, TatD family'
GCE56_07915	COG0537	adenosine 5'-monophosphoramidase activity
GCE56_07920	COG5633	Lipoprotein
GCE56_07925	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
GCE56_07935	COG1472	Belongs to the glycosyl hydrolase 3 family
GCE56_07945	COG1252	NADH dehydrogenase
GCE56_07950	COG3134	Outer membrane lipoprotein
GCE56_07955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GCE56_07960	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCE56_07970	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCE56_07990	COG2850	peptidyl-arginine hydroxylation
GCE56_07995	COG2205	protein histidine kinase activity
GCE56_08000	COG0745	RESPONSE REGULATOR receiver
GCE56_08005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GCE56_08010	COG2915	High frequency lysogenization protein hflD homolog
GCE56_08015	COG0482	sulfurtransferase activity
GCE56_08025	COG1187	pseudouridine synthase activity
GCE56_08030	COG0538	isocitrate dehydrogenase activity
GCE56_08035	COG0582	viral genome integration into host DNA
GCE56_08045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GCE56_08050	COG5532	Uncharacterized conserved protein (DUF2303)
GCE56_08070	COG4197	protein conserved in bacteria, prophage-related
GCE56_08100	COG1403	HNH endonuclease
GCE56_08110	COG1278	Cold shock
GCE56_08115	COG3477	response to acidic pH
GCE56_08120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GCE56_08125	COG4977	sequence-specific DNA binding
GCE56_08125	COG1917	Cupin 2, conserved barrel domain protein
GCE56_08145	COG3772	lysozyme
GCE56_08170	COG4626	Terminase
GCE56_08170	COG1802	Transcriptional regulator
GCE56_08305	COG0538	isocitrate dehydrogenase activity
GCE56_08330	COG0538	isocitrate dehydrogenase activity
GCE56_08345	COG1278	Cold shock
GCE56_08350	COG0071	Belongs to the small heat shock protein (HSP20) family
GCE56_08360	COG1733	regulation of RNA biosynthetic process
GCE56_08365	COG0702	epimerase
GCE56_08375	COG0572	uridine kinase
GCE56_08395	COG1475	DNA binding
GCE56_08400	COG3969	phosphoadenosine phosphosulfate
GCE56_08405	COG0500	methyltransferase
GCE56_08415	COG3272	Protein of unknown function (DUF1722)
GCE56_08420	COG2841	Protein conserved in bacteria
GCE56_08450	COG0024	Methionine aminopeptidase
GCE56_08460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GCE56_08465	COG1598	PFAM Uncharacterised protein family UPF0150
GCE56_08470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GCE56_08490	COG1528	Iron-storage protein
GCE56_08495	COG2372	response to copper ion
GCE56_08500	COG1276	copper resistance
GCE56_08515	COG3008	intermembrane lipid transfer
GCE56_08520	COG2995	paraquat-inducible protein a
GCE56_08525	COG1956	GAF domain-containing protein
GCE56_08530	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GCE56_08545	COG0501	Belongs to the peptidase M48B family
GCE56_08560	COG1988	membrane-bound metal-dependent
GCE56_08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCE56_08575	COG3001	Fructosamine kinase
GCE56_08580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GCE56_08585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GCE56_08590	COG1121	(ABC) transporter
GCE56_08595	COG0803	Belongs to the bacterial solute-binding protein 9 family
GCE56_08615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCE56_08625	COG3539	Fimbrial protein
GCE56_08630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GCE56_08635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GCE56_08640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GCE56_08645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GCE56_08655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GCE56_08660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GCE56_08660	COG0072	phenylalanine-tRNA ligase activity
GCE56_08665	COG0776	regulation of translation
GCE56_08670	COG4139	cobalamin transport
GCE56_08675	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GCE56_08680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GCE56_08685	COG0463	Glycosyl transferase, family 2
GCE56_08690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GCE56_08690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GCE56_08695	COG0726	polysaccharide deacetylase
GCE56_08700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GCE56_08705	COG2076	Multidrug Resistance protein
GCE56_08710	COG2076	Multidrug Resistance protein
GCE56_08715	COG0791	NLP P60 protein
GCE56_08720	COG0095	Lipoate-protein ligase
GCE56_08725	COG2207	Transcriptional regulator
GCE56_08730	COG0579	oxidoreductase
GCE56_08735	COG2186	Transcriptional regulator
GCE56_08750	COG0586	Pfam SNARE associated Golgi protein
GCE56_08810	COG3209	COG3209 Rhs family protein
GCE56_08825	COG0012	GTP binding
GCE56_08830	COG0193	aminoacyl-tRNA hydrolase activity
GCE56_08840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GCE56_08845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GCE56_08850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GCE56_08855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GCE56_08860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GCE56_08870	COG2912	Transglutaminase-like superfamily
GCE56_08875	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GCE56_08880	COG1242	4 iron, 4 sulfur cluster binding
GCE56_08895	COG0659	secondary active sulfate transmembrane transporter activity
GCE56_08905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCE56_08920	COG3381	protein complex oligomerization
GCE56_08930	COG0477	Major facilitator Superfamily
GCE56_08935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCE56_08940	COG0728	peptidoglycan biosynthetic process
GCE56_08950	COG0018	arginyl-trna synthetase
GCE56_08955	COG3102	Protein conserved in bacteria
GCE56_08960	COG3142	Participates in the control of copper homeostasis
GCE56_08970	COG0488	(ABC) transporter
GCE56_08975	COG0500	methyltransferase
GCE56_08980	COG2226	methyltransferase
GCE56_08985	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GCE56_08990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GCE56_08995	COG0494	nUDIX hydrolase
GCE56_09000	COG0217	transcriptional regulatory protein
GCE56_09005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GCE56_09010	COG0632	four-way junction helicase activity
GCE56_09015	COG2255	four-way junction helicase activity
GCE56_09065	COG2801	Transposase and inactivated derivatives
GCE56_09090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GCE56_09095	COG1121	(ABC) transporter
GCE56_09100	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GCE56_09105	COG0739	heme binding
GCE56_09110	COG1560	Kdo2-lipid A biosynthetic process
GCE56_09115	COG0469	pyruvate kinase activity
GCE56_09120	COG1737	Transcriptional regulator
GCE56_09125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GCE56_09130	COG2076	Multidrug Resistance protein
GCE56_09135	COG2076	Multidrug Resistance protein
GCE56_09140	COG0702	epimerase
GCE56_09145	COG0251	oxidation-reduction process
GCE56_09150	COG1199	ATP-dependent helicase activity
GCE56_09160	COG3065	identical protein binding
GCE56_09165	COG0318	PFAM AMP-dependent synthetase and ligase
GCE56_09170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GCE56_09175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GCE56_09180	COG2894	cell division
GCE56_09185	COG0850	regulation of cytokinetic process
GCE56_09190	COG3100	YcgL domain-containing protein
GCE56_09195	COG2951	lytic endotransglycosylase activity
GCE56_09200	COG0179	Fumarylacetoacetate (FAA) hydrolase
GCE56_09205	COG2983	Belongs to the UPF0260 family
GCE56_09210	COG0390	transport system, permease component
GCE56_09215	COG4619	ABC transporter
GCE56_09225	COG3708	Transcriptional regulator
GCE56_09225	COG2207	Transcriptional regulator
GCE56_09235	COG0840	transmembrane signaling receptor activity
GCE56_09240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GCE56_09245	COG2911	Protein conserved in bacteria
GCE56_09255	COG3784	Protein of unknown function (DUF1318)
GCE56_09280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GCE56_09295	COG1643	Atp-dependent helicase
GCE56_09310	COG3188	usher protein
GCE56_09325	COG0531	amino acid
GCE56_09335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GCE56_09340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GCE56_09345	COG0589	response to stress
GCE56_09350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCE56_09355	COG0243	molybdopterin cofactor binding
GCE56_09360	COG0437	4 iron, 4 sulfur cluster binding
GCE56_09375	COG3321	synthase
GCE56_09375	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_09375	COG0604	alcohol dehydrogenase
GCE56_09385	COG1695	Transcriptional regulator
GCE56_09400	COG3634	alkyl hydroperoxide reductase activity
GCE56_09445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GCE56_09450	COG4974	Belongs to the 'phage' integrase family
GCE56_09460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCE56_09465	COG1129	ABC transporter
GCE56_09465	COG0842	Transport permease protein
GCE56_09470	COG0842	Transport permease protein
GCE56_09475	COG0745	RESPONSE REGULATOR receiver
GCE56_09500	COG2376	Dihydroxyacetone kinase
GCE56_09510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCE56_09520	COG0251	oxidation-reduction process
GCE56_09540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GCE56_09545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GCE56_09545	COG2169	Transcriptional regulator
GCE56_09560	COG1181	Belongs to the D-alanine--D-alanine ligase family
GCE56_09580	COG1464	Belongs to the NlpA lipoprotein family
GCE56_09600	COG2814	Major facilitator Superfamily
GCE56_09610	COG0583	DNA-binding transcription factor activity
GCE56_09620	COG1309	transcriptional regulator
GCE56_09630	COG0488	(ABC) transporter
GCE56_09635	COG1671	Belongs to the UPF0178 family
GCE56_09640	COG0402	S-adenosylhomocysteine deaminase activity
GCE56_09650	COG2814	Major facilitator Superfamily
GCE56_09655	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GCE56_09670	COG1289	transmembrane transporter activity
GCE56_09675	COG1538	Outer membrane efflux protein
GCE56_09685	COG0443	Heat shock 70 kDa protein
GCE56_09705	COG1070	Carbohydrate kinase
GCE56_09710	COG2115	Belongs to the xylose isomerase family
GCE56_09715	COG1757	Na H antiporter
GCE56_09720	COG0436	Aminotransferase
GCE56_09725	COG2207	Transcriptional regulator
GCE56_09725	COG1609	Transcriptional regulator
GCE56_09730	COG4628	conserved protein (DUF2132)
GCE56_09760	COG3157	Type VI secretion system effector, Hcp
GCE56_09790	COG4221	oxidoreductase activity
GCE56_09805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GCE56_09810	COG1940	carbohydrate kinase activity
GCE56_09815	COG0583	DNA-binding transcription factor activity
GCE56_09820	COG2814	Major facilitator Superfamily
GCE56_09830	COG0114	fumarate hydratase activity
GCE56_09835	COG5339	Protein conserved in bacteria
GCE56_09845	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GCE56_09850	COG0385	Bile acid
GCE56_09855	COG0673	inositol 2-dehydrogenase activity
GCE56_09865	COG4657	Part of a membrane complex involved in electron transport
GCE56_09875	COG4656	Part of a membrane complex involved in electron transport
GCE56_09885	COG4659	FMN binding
GCE56_09895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GCE56_09900	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GCE56_09905	COG0023	Translation Initiation Factor
GCE56_09910	COG0284	orotidine-5'-phosphate decarboxylase activity
GCE56_09915	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GCE56_09920	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GCE56_09925	COG0671	phosphoesterase, PA-phosphatase related
GCE56_09930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GCE56_09935	COG1464	Belongs to the NlpA lipoprotein family
GCE56_09945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GCE56_09955	COG0583	DNA-binding transcription factor activity
GCE56_09990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCE56_10000	COG0616	signal peptide processing
GCE56_10005	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_10020	COG1187	pseudouridine synthase activity
GCE56_10025	COG0009	L-threonylcarbamoyladenylate synthase
GCE56_10035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GCE56_10040	COG0512	Glutamine amidotransferase of anthranilate synthase
GCE56_10045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GCE56_10055	COG0133	tryptophan synthase activity
GCE56_10060	COG0159	tryptophan synthase activity
GCE56_10070	COG3047	cAMP biosynthetic process
GCE56_10105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GCE56_10120	COG0346	lactoylglutathione lyase activity
GCE56_10140	COG0598	Magnesium transport protein CorA
GCE56_10155	COG4166	transmembrane transport
GCE56_10160	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GCE56_10175	COG3768	UPF0283 membrane protein
GCE56_10180	COG3106	COG3106 Predicted ATPase
GCE56_10190	COG1983	PspC domain protein
GCE56_10200	COG1842	Phage shock protein A
GCE56_10205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GCE56_10210	COG4166	transmembrane transport
GCE56_10220	COG4171	peptide transport system, permease
GCE56_10225	COG4172	Belongs to the ABC transporter superfamily
GCE56_10235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GCE56_10250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GCE56_10255	COG0259	pyridoxamine-phosphate oxidase activity
GCE56_10260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GCE56_10275	COG3313	Fe-S protein
GCE56_10280	COG0346	lactoylglutathione lyase activity
GCE56_10285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCE56_10290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GCE56_10300	COG0730	response to heat
GCE56_10315	COG1609	Transcriptional regulator
GCE56_10320	COG0583	DNA-binding transcription factor activity
GCE56_10325	COG2814	Major facilitator Superfamily
GCE56_10330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GCE56_10335	COG0307	riboflavin synthase, alpha
GCE56_10340	COG0534	Mate efflux family protein
GCE56_10360	COG0531	amino acid
GCE56_10365	COG0076	glutamate decarboxylase activity
GCE56_10380	COG1376	ErfK ybiS ycfS ynhG family protein
GCE56_10380	COG1388	LysM domain
GCE56_10385	COG2166	iron-sulfur cluster assembly
GCE56_10390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GCE56_10395	COG0719	Fe-S assembly protein
GCE56_10400	COG0396	ATPase activity
GCE56_10405	COG0719	Fe-S assembly protein
GCE56_10410	COG0316	Belongs to the HesB IscA family
GCE56_10420	COG2050	protein possibly involved in aromatic compounds catabolism
GCE56_10425	COG0247	lactate metabolic process
GCE56_10425	COG0277	FAD linked oxidase domain protein
GCE56_10430	COG0628	permease
GCE56_10435	COG0574	Belongs to the PEP-utilizing enzyme family
GCE56_10435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCE56_10440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GCE56_10445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GCE56_10460	COG4771	TonB-dependent receptor
GCE56_10465	COG3720	iron ion transport
GCE56_10470	COG4558	Periplasmic binding protein
GCE56_10475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCE56_10480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GCE56_10490	COG1280	lysine exporter protein (LysE YggA)
GCE56_10495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GCE56_10500	COG1271	oxidase subunit
GCE56_10505	COG1294	oxidase, subunit
GCE56_10520	COG3152	Membrane
GCE56_10525	COG1702	phosphate starvation-inducible protein PhoH
GCE56_10535	COG2356	endonuclease I
GCE56_10545	COG3610	response to peptide
GCE56_10550	COG2966	Psort location CytoplasmicMembrane, score
GCE56_10565	COG0589	response to stress
GCE56_10575	COG0589	response to stress
GCE56_10595	COG0113	porphobilinogen synthase activity
GCE56_10605	COG0402	S-adenosylhomocysteine deaminase activity
GCE56_10610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GCE56_10615	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GCE56_10620	COG1012	belongs to the aldehyde dehydrogenase family
GCE56_10625	COG1309	transcriptional regulator
GCE56_10630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GCE56_10635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GCE56_10650	COG3188	usher protein
GCE56_10660	COG3539	Fimbrial protein
GCE56_10670	COG1396	sequence-specific DNA binding
GCE56_10680	COG0444	Belongs to the ABC transporter superfamily
GCE56_10685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCE56_10715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GCE56_10720	COG4166	transmembrane transport
GCE56_10725	COG0601	transmembrane transport
GCE56_10740	COG4608	Belongs to the ABC transporter superfamily
GCE56_10745	COG2095	MarC family integral membrane protein
GCE56_10750	COG1454	alcohol dehydrogenase
GCE56_10750	COG1012	belongs to the aldehyde dehydrogenase family
GCE56_10755	COG1435	thymidine kinase activity
GCE56_10770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCE56_10775	COG0745	RESPONSE REGULATOR receiver
GCE56_10780	COG3012	SEC-C Motif Domain Protein
GCE56_10785	COG0788	formyltetrahydrofolate deformylase activity
GCE56_10795	COG0583	DNA-binding transcription factor activity
GCE56_10800	COG0708	Exodeoxyribonuclease III
GCE56_10805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCE56_10810	COG0709	Synthesizes selenophosphate from selenide and ATP
GCE56_10815	COG0778	Nitroreductase
GCE56_10820	COG0616	signal peptide processing
GCE56_10825	COG0252	asparaginase activity
GCE56_10830	COG1335	isochorismatase
GCE56_10835	COG3139	Protein of unknown function (DUF1315)
GCE56_10840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GCE56_10855	COG3713	MltA-interacting MipA family protein
GCE56_10860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GCE56_10865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GCE56_10870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCE56_10875	COG2186	Transcriptional regulator
GCE56_10880	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GCE56_10885	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GCE56_10895	COG2076	Multidrug Resistance protein
GCE56_10915	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GCE56_10920	COG3683	transport system, periplasmic component
GCE56_10950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GCE56_10955	COG0322	excinuclease ABC activity
GCE56_10960	COG2197	response regulator
GCE56_10965	COG0778	Nitroreductase
GCE56_10970	COG1494	fructose-1,6-bisphosphatase
GCE56_10975	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GCE56_10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCE56_11035	COG3842	ATPase activity
GCE56_11040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GCE56_11045	COG0725	ABC transporter, periplasmic molybdate-binding protein
GCE56_11050	COG2390	Transcriptional regulator
GCE56_11055	COG1324	tolerance protein
GCE56_11070	COG3541	Predicted nucleotidyltransferase
GCE56_11235	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GCE56_11245	COG1484	DNA-dependent DNA replication
GCE56_11325	COG0582	viral genome integration into host DNA
GCE56_11330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GCE56_11330	COG0519	Catalyzes the synthesis of GMP from XMP
GCE56_11335	COG0516	GMP reductase activity
GCE56_11335	COG0517	IMP dehydrogenase activity
GCE56_11340	COG1570	exodeoxyribonuclease VII activity
GCE56_11345	COG4206	TonB-dependent receptor
GCE56_11345	COG1629	transport
GCE56_11350	COG1770	oligopeptidase
GCE56_11365	COG0280	phosphate acetyltransferase
GCE56_11365	COG0281	malic enzyme
GCE56_11370	COG2197	response regulator
GCE56_11380	COG1393	Belongs to the ArsC family
GCE56_11385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GCE56_11390	COG1876	peptidase activity
GCE56_11400	COG2832	Protein of unknown function (DUF454)
GCE56_11410	COG1444	tRNA N-acetyltransferase activity
GCE56_11415	COG2707	UPF0756 membrane protein
GCE56_11420	COG2321	neutral zinc metallopeptidase
GCE56_11425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GCE56_11430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GCE56_11435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCE56_11440	COG2716	regulation of RNA biosynthetic process
GCE56_11445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GCE56_11450	COG0628	permease
GCE56_11455	COG4783	chaperone-mediated protein folding
GCE56_11460	COG1393	Belongs to the ArsC family
GCE56_11465	COG2211	Major facilitator Superfamily
GCE56_11470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GCE56_11475	COG0668	transmembrane transport
GCE56_11480	COG2233	PERMEase
GCE56_11485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GCE56_11490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GCE56_11495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GCE56_11500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCE56_11505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GCE56_11515	COG2239	Acts as a magnesium transporter
GCE56_11540	COG3104	oligopeptide transport
GCE56_11545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCE56_11550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCE56_11555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCE56_11560	COG2205	protein histidine kinase activity
GCE56_11565	COG0745	RESPONSE REGULATOR receiver
GCE56_11575	COG1597	lipid kinase activity
GCE56_11580	COG1830	Aldolase
GCE56_11600	COG1113	amino acid transport
GCE56_11615	COG0561	phosphatase activity
GCE56_11620	COG1114	Component of the transport system for branched-chain amino acids
GCE56_11625	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCE56_11630	COG1115	amino acid carrier protein
GCE56_11645	COG3140	Belongs to the UPF0181 family
GCE56_11655	COG0494	nUDIX hydrolase
GCE56_11660	COG1760	l-serine dehydratase
GCE56_11665	COG1971	Probably functions as a manganese efflux pump
GCE56_11670	COG2226	methyltransferase
GCE56_11680	COG0589	response to stress
GCE56_11695	COG1113	amino acid transport
GCE56_11705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCE56_11710	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GCE56_11710	COG0506	proline dehydrogenase activity
GCE56_11710	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GCE56_11720	COG1191	sigma factor activity
GCE56_11775	COG1677	Flagellar hook-basal body complex protein FliE
GCE56_11780	COG1766	The M ring may be actively involved in energy transduction
GCE56_11795	COG1157	protein secretion by the type III secretion system
GCE56_11800	COG2882	bacterial-type flagellum organization
GCE56_11810	COG1580	Controls the rotational direction of flagella during chemotaxis
GCE56_11830	COG1338	Plays a role in the flagellum-specific transport system
GCE56_11835	COG1987	bacterial-type flagellum assembly
GCE56_11850	COG1256	bacterial-type flagellum assembly
GCE56_11860	COG1706	bacterial-type flagellum-dependent cell motility
GCE56_11865	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GCE56_11890	COG1558	bacterial-type flagellum-dependent cell motility
GCE56_11895	COG1815	bacterial-type flagellum-dependent cell motility
GCE56_11915	COG3210	domain, Protein
GCE56_11930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GCE56_11945	COG0745	RESPONSE REGULATOR receiver
GCE56_11950	COG2201	protein-glutamate methylesterase activity
GCE56_11970	COG1285	pathogenesis
GCE56_12010	COG0418	dihydroorotase activity
GCE56_12050	COG1560	Kdo2-lipid A biosynthetic process
GCE56_12055	COG2814	Major facilitator Superfamily
GCE56_12060	COG3104	oligopeptide transport
GCE56_12075	COG1607	acyl-coa hydrolase
GCE56_12085	COG5295	Hep Hag repeat protein
GCE56_12085	COG5295	Hep Hag repeat protein
GCE56_12090	COG1902	pentaerythritol trinitrate reductase activity
GCE56_12115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GCE56_12120	COG1396	sequence-specific DNA binding
GCE56_12130	COG3247	response to pH
GCE56_12140	COG0668	transmembrane transport
GCE56_12145	COG0243	molybdopterin cofactor binding
GCE56_12150	COG0437	4 iron, 4 sulfur cluster binding
GCE56_12155	COG3302	dmso reductase anchor subunit
GCE56_12285	COG2198	Histidine kinase
GCE56_12285	COG0642	Histidine kinase
GCE56_12290	COG2197	response regulator
GCE56_12295	COG2205	protein histidine kinase activity
GCE56_12295	COG0784	Response regulator, receiver
GCE56_12305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GCE56_12310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCE56_12315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GCE56_12320	COG0633	Ferredoxin
GCE56_12330	COG0814	amino acid
GCE56_12350	COG1441	menaquinone biosynthetic process
GCE56_12355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GCE56_12360	COG0596	Alpha beta hydrolase
GCE56_12365	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GCE56_12370	COG1169	isochorismate synthase
GCE56_12385	COG1007	ATP synthesis coupled electron transport
GCE56_12390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCE56_12395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCE56_12400	COG0713	ATP synthesis coupled electron transport
GCE56_12405	COG0839	Belongs to the complex I subunit 6 family
GCE56_12410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCE56_12415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GCE56_12425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GCE56_12435	COG0649	NAD binding
GCE56_12435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCE56_12440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCE56_12445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCE56_12455	COG0583	DNA-binding transcription factor activity
GCE56_12460	COG0436	Aminotransferase
GCE56_12465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GCE56_12470	COG0490	domain, Protein
GCE56_12470	COG0471	metal ion transport
GCE56_12475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCE56_12480	COG3013	Belongs to the UPF0304 family
GCE56_12485	COG3092	negative regulation of chromosome organization
GCE56_12490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GCE56_12495	COG0280	phosphate acetyltransferase
GCE56_12495	COG0857	belongs to the CobB CobQ family
GCE56_12525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GCE56_12530	COG1518	maintenance of DNA repeat elements
GCE56_12560	COG1203	CRISPR-associated helicase, Cas3
GCE56_12565	COG3037	sugar-specific permease SgaT UlaA
GCE56_12575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCE56_12585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GCE56_12590	COG0625	glutathione transferase activity
GCE56_12595	COG1090	epimerase
GCE56_12600	COG0163	prenyltransferase activity
GCE56_12605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GCE56_12610	COG1286	toxin biosynthetic process
GCE56_12615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GCE56_12620	COG0285	dihydrofolate synthase activity
GCE56_12625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GCE56_12630	COG0586	Pfam SNARE associated Golgi protein
GCE56_12640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GCE56_12645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCE56_12650	COG2207	Transcriptional regulator
GCE56_12655	COG0697	spore germination
GCE56_12660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCE56_12665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCE56_12665	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GCE56_12685	COG3101	peptidyl-lysine hydroxylation
GCE56_12690	COG0730	response to heat
GCE56_12695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GCE56_12705	COG0783	Belongs to the Dps family
GCE56_12710	COG2840	Smr protein MutS2
GCE56_12715	COG2062	phosphohistidine phosphatase, SixA
GCE56_12720	COG1024	Enoyl-CoA hydratase
GCE56_12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
GCE56_12725	COG0183	Belongs to the thiolase family
GCE56_12730	COG3691	Protein conserved in bacteria
GCE56_12735	COG2067	long-chain fatty acid transport protein
GCE56_12775	COG1396	sequence-specific DNA binding
GCE56_12820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GCE56_12835	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_12845	COG3530	Putative quorum-sensing-regulated virulence factor
GCE56_12850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCE56_12855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GCE56_12865	COG3115	cell septum assembly
GCE56_12875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GCE56_12880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCE56_12890	COG2190	(PTS) system
GCE56_12895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GCE56_12900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GCE56_12905	COG4208	sulfate ABC transporter
GCE56_12910	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GCE56_12920	COG2837	iron assimilation
GCE56_12930	COG0456	acetyltransferase
GCE56_12935	COG0408	coproporphyrinogen oxidase activity
GCE56_12945	COG1160	GTP binding
GCE56_12950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GCE56_12955	COG2976	Protein conserved in bacteria
GCE56_12960	COG0124	histidyl-tRNA synthetase
GCE56_12965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GCE56_12980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GCE56_12985	COG0105	UTP biosynthetic process
GCE56_12990	COG4953	penicillin-binding protein 1C
GCE56_12995	COG2373	Large extracellular alpha-helical protein
GCE56_13005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GCE56_13010	COG2975	iron-sulfur cluster assembly
GCE56_13015	COG0633	Ferredoxin
GCE56_13020	COG0443	Heat shock 70 kDa protein
GCE56_13025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCE56_13030	COG0316	Belongs to the HesB IscA family
GCE56_13035	COG0822	iron-sulfur transferase activity
GCE56_13040	COG1104	cysteine desulfurase activity
GCE56_13045	COG1959	2 iron, 2 sulfur cluster binding
GCE56_13050	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GCE56_13055	COG0483	inositol monophosphate 1-phosphatase activity
GCE56_13070	COG2814	Major facilitator Superfamily
GCE56_13075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GCE56_13080	COG1017	nitric oxide dioxygenase activity
GCE56_13080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCE56_13090	COG0347	Belongs to the P(II) protein family
GCE56_13095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCE56_13095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GCE56_13100	COG2204	response regulator
GCE56_13105	COG3170	Tfp pilus assembly protein FimV
GCE56_13110	COG2205	protein histidine kinase activity
GCE56_13115	COG0047	phosphoribosylformylglycinamidine synthase activity
GCE56_13115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GCE56_13120	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GCE56_13125	COG3539	Fimbrial protein
GCE56_13130	COG3188	usher protein
GCE56_13135	COG3121	Chaperone
GCE56_13140	COG3539	Fimbrial protein
GCE56_13145	COG3539	Fimbrial protein
GCE56_13155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCE56_13160	COG0736	holo-[acyl-carrier-protein] synthase activity
GCE56_13165	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GCE56_13170	COG1381	Involved in DNA repair and RecF pathway recombination
GCE56_13175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GCE56_13180	COG0571	ribonuclease III activity
GCE56_13185	COG0681	Belongs to the peptidase S26 family
GCE56_13190	COG0481	GTPase activity
GCE56_13195	COG3086	response to oxidative stress
GCE56_13200	COG3026	antisigma factor binding
GCE56_13205	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GCE56_13210	COG1595	DNA-templated transcription, initiation
GCE56_13215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GCE56_13220	COG0513	Belongs to the DEAD box helicase family
GCE56_13225	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GCE56_13235	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GCE56_13240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GCE56_13245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GCE56_13250	COG0497	DNA recombination
GCE56_13260	COG2914	Belongs to the UPF0125 (RnfH) family
GCE56_13265	COG2867	negative regulation of translational initiation
GCE56_13270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GCE56_13290	COG1674	ftsk spoiiie
GCE56_13290	COG0531	amino acid
GCE56_13370	COG0579	oxidoreductase
GCE56_13385	COG2249	NAD(P)H dehydrogenase (quinone) activity
GCE56_13390	COG1620	l-lactate permease
GCE56_13395	COG0247	lactate metabolic process
GCE56_13400	COG1139	Iron-sulfur cluster binding protein
GCE56_13405	COG1556	Lactate utilization protein
GCE56_13420	COG0727	PFAM Uncharacterised protein family (UPF0153)
GCE56_13425	COG3738	Protein conserved in bacteria
GCE56_13435	COG2819	hydrolase of the alpha beta superfamily
GCE56_13440	COG4771	TonB-dependent receptor
GCE56_13450	COG1609	Transcriptional regulator
GCE56_13455	COG2017	converts alpha-aldose to the beta-anomer
GCE56_13460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GCE56_13465	COG1085	galactose-1-phosphate uridylyltransferase
GCE56_13470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GCE56_13480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GCE56_13485	COG0589	response to stress
GCE56_13490	COG4574	serine-type endopeptidase inhibitor activity
GCE56_13495	COG2841	Protein conserved in bacteria
GCE56_13565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GCE56_13575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GCE56_13580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCE56_13590	COG0716	FMN binding
GCE56_13605	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GCE56_13610	COG0354	folic acid binding
GCE56_13620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCE56_13620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GCE56_13625	COG0509	glycine decarboxylation via glycine cleavage system
GCE56_13630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GCE56_13635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCE56_13640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GCE56_13645	COG0006	proline dipeptidase activity
GCE56_13650	COG3079	Belongs to the UPF0149 family
GCE56_13655	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GCE56_13665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GCE56_13675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GCE56_13685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GCE56_13690	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GCE56_13695	COG0583	DNA-binding transcription factor activity
GCE56_13715	COG1279	arginine transmembrane transporter activity
GCE56_13725	COG3112	Uncharacterised protein family (UPF0231)
GCE56_13745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GCE56_13750	COG0508	dehydrogenase complex catalyzes the overall conversion of
GCE56_13755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GCE56_13760	COG2186	Transcriptional regulator
GCE56_13765	COG3023	N-Acetylmuramoyl-L-alanine amidase
GCE56_13770	COG4969	Belongs to the N-Me-Phe pilin family
GCE56_13775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GCE56_13785	COG0237	dephospho-CoA kinase activity
GCE56_13790	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GCE56_13795	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GCE56_13820	COG0789	Transcriptional regulator
GCE56_13825	COG0653	protein targeting
GCE56_13840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GCE56_13850	COG0849	cell division
GCE56_13855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GCE56_13865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GCE56_13870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GCE56_13875	COG0772	Belongs to the SEDS family
GCE56_13885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GCE56_13890	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GCE56_13895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GCE56_13900	COG0768	penicillin binding
GCE56_13910	COG0275	rRNA processing
GCE56_13915	COG2001	Belongs to the MraZ family
GCE56_13925	COG1022	Amp-dependent synthetase and ligase
GCE56_13940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GCE56_13945	COG0473	3-isopropylmalate dehydrogenase activity
GCE56_13950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GCE56_13955	COG0066	3-isopropylmalate dehydratase activity
GCE56_13960	COG4533	DNA binding
GCE56_13965	COG3066	DNA modification
GCE56_13975	COG3657	addiction module killer protein
GCE56_13985	COG0010	Belongs to the arginase family
GCE56_13990	COG1166	arginine decarboxylase activity
GCE56_13995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GCE56_14010	COG1192	Involved in chromosome partitioning
GCE56_14020	COG1215	transferase activity, transferring glycosyl groups
GCE56_14025	COG0457	Tetratricopeptide repeat
GCE56_14025	COG3118	belongs to the thioredoxin family
GCE56_14040	COG0640	Transcriptional regulator
GCE56_14045	COG3091	SprT-like family
GCE56_14050	COG2239	Acts as a magnesium transporter
GCE56_14060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GCE56_14065	COG1151	hydroxylamine reductase activity
GCE56_14075	COG1115	amino acid carrier protein
GCE56_14090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCE56_14095	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GCE56_14100	COG2353	YceI-like domain
GCE56_14105	COG3038	cytochrome b561
GCE56_14120	COG5295	Hep Hag repeat protein
GCE56_14130	COG3119	arylsulfatase activity
GCE56_14175	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_14185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GCE56_14190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCE56_14190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_14195	COG3716	PTS system mannose fructose sorbose family IID component
GCE56_14200	COG3715	PTS system
GCE56_14205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_14210	COG2222	sugar isomerase
GCE56_14220	COG1349	DNA-binding transcription factor activity
GCE56_14225	COG0641	radical SAM
GCE56_14230	COG3119	arylsulfatase activity
GCE56_14245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCE56_14250	COG0800	Aldolase
GCE56_14270	COG0384	phenazine biosynthesis protein PhzF
GCE56_14275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GCE56_14280	COG0640	Transcriptional regulator
GCE56_14285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GCE56_14425	COG3561	AntA/AntB antirepressor
GCE56_14440	COG0582	viral genome integration into host DNA
GCE56_14450	COG3594	Acyltransferase
GCE56_14675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GCE56_14685	COG2974	May be involved in recombination
GCE56_14695	COG1846	Transcriptional regulator
GCE56_14700	COG3646	Phage regulatory protein
GCE56_14700	COG3645	SOS response
GCE56_14815	COG0582	viral genome integration into host DNA
GCE56_14825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GCE56_14830	COG2501	S4 domain
GCE56_14835	COG1105	Belongs to the carbohydrate kinase PfkB family
GCE56_14840	COG0215	cysteine-tRNA ligase activity
GCE56_14845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCE56_14850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCE56_14855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GCE56_14860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GCE56_14870	COG0668	transmembrane transport
GCE56_14875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GCE56_14880	COG4181	ATPase activity
GCE56_14885	COG2755	lipolytic protein G-D-S-L family
GCE56_14890	COG0300	oxidoreductase activity
GCE56_14895	COG3118	belongs to the thioredoxin family
GCE56_14900	COG0330	HflC and HflK could
GCE56_14910	COG0789	Transcriptional regulator
GCE56_14915	COG2217	Heavy metal translocating P-type atpase
GCE56_14925	COG3735	TraB family
GCE56_14935	COG0737	Belongs to the 5'-nucleotidase family
GCE56_14940	COG4651	solute:proton antiporter activity
GCE56_14940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GCE56_14945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCE56_14950	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GCE56_14955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GCE56_14960	COG0563	adenylate kinase activity
GCE56_14965	COG0326	Molecular chaperone. Has ATPase activity
GCE56_14970	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GCE56_14975	COG2962	Rard protein
GCE56_14995	COG4566	intracellular signal transduction
GCE56_15010	COG4589	Belongs to the CDS family
GCE56_15020	COG0583	DNA-binding transcription factor activity
GCE56_15030	COG0549	Belongs to the carbamate kinase family
GCE56_15040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GCE56_15045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GCE56_15050	COG1335	isochorismatase
GCE56_15065	COG0471	metal ion transport
GCE56_15090	COG3539	Fimbrial protein
GCE56_15160	COG0613	PHP domain protein
GCE56_15165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_15165	COG2190	(PTS) system
GCE56_15165	COG1263	PTS System
GCE56_15170	COG3711	transcriptional antiterminator
GCE56_15210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GCE56_15220	COG4942	peptidase
GCE56_15220	COG1388	LysM domain
GCE56_15225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GCE56_15230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GCE56_15235	COG0585	pseudouridine synthase activity
GCE56_15240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GCE56_15245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GCE56_15260	COG2895	sulfate adenylyltransferase (ATP) activity
GCE56_15265	COG0175	sulfate reduction
GCE56_15270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GCE56_15270	COG1648	precorrin-2 dehydrogenase activity
GCE56_15275	COG0175	sulfate reduction
GCE56_15280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GCE56_15285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GCE56_15290	COG0720	synthase
GCE56_15295	COG0602	queuosine metabolic process
GCE56_15350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GCE56_15355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GCE56_15360	COG2011	ABC-type metal ion transport system permease component
GCE56_15365	COG1464	Belongs to the NlpA lipoprotein family
GCE56_15375	COG1720	tRNA m6t6A37 methyltransferase activity
GCE56_15380	COG0442	prolyl-tRNA aminoacylation
GCE56_15385	COG3015	lipoprotein NlpE involved in copper resistance
GCE56_15390	COG4568	rho-dependent transcription termination
GCE56_15395	COG0037	tRNA processing
GCE56_15405	COG0825	malonyl-CoA metabolic process
GCE56_15415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GCE56_15420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCE56_15425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCE56_15430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCE56_15435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GCE56_15455	COG0575	Belongs to the CDS family
GCE56_15460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GCE56_15465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GCE56_15470	COG0233	cytoplasmic translational termination
GCE56_15475	COG0528	UMP kinase activity
GCE56_15480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GCE56_15485	COG0052	Belongs to the universal ribosomal protein uS2 family
GCE56_15495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GCE56_15500	COG2171	N-acyltransferase activity
GCE56_15510	COG0716	FMN binding
GCE56_15525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_15525	COG1263	PTS System
GCE56_15535	COG3098	single-species biofilm formation
GCE56_15545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCE56_15545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GCE56_15550	COG1611	Belongs to the LOG family
GCE56_15555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GCE56_15560	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GCE56_15565	COG2363	Small membrane protein
GCE56_15570	COG0583	DNA-binding transcription factor activity
GCE56_15575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GCE56_15580	COG2166	iron-sulfur cluster assembly
GCE56_15585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GCE56_15590	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GCE56_15610	COG0860	N-Acetylmuramoyl-L-alanine amidase
GCE56_15615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GCE56_15615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GCE56_15620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GCE56_15625	COG1074	ATP-dependent DNA helicase activity
GCE56_15630	COG1025	Belongs to the peptidase M16 family
GCE56_15635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GCE56_15670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GCE56_15680	COG0494	nUDIX hydrolase
GCE56_15685	COG4143	(ABC) transporter
GCE56_15690	COG1178	ABC-type Fe3 transport system permease component
GCE56_15695	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GCE56_15700	COG3311	Transcriptional regulator
GCE56_15710	COG0417	DNA replication proofreading
GCE56_15715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GCE56_15720	COG0564	pseudouridine synthase activity
GCE56_15725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GCE56_15730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GCE56_15735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GCE56_15740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GCE56_15745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GCE56_15750	COG2967	ApaG domain
GCE56_15755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GCE56_15775	COG2132	Multicopper oxidase
GCE56_15780	COG0204	Acyl-transferase
GCE56_15785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GCE56_15790	COG0187	DNA topoisomerase II activity
GCE56_15795	COG3150	esterase
GCE56_15800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GCE56_15805	COG0494	nUDIX hydrolase
GCE56_15810	COG1538	Outer membrane efflux protein
GCE56_15815	COG5463	Belongs to the UPF0441 family
GCE56_15820	COG0754	glutathionylspermidine amidase activity
GCE56_15825	COG3384	dioxygenase
GCE56_15830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GCE56_15850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GCE56_15850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GCE56_15855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GCE56_15860	COG3025	triphosphatase activity
GCE56_15865	COG4991	sh3 domain protein
GCE56_15870	COG0617	tRNA 3'-terminal CCA addition
GCE56_15875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GCE56_15880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GCE56_15900	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GCE56_15905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GCE56_15910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GCE56_15915	COG0358	DNA primase activity
GCE56_15945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GCE56_15965	COG2963	transposase activity
GCE56_15970	COG3781	membrane
GCE56_15980	COG1294	oxidase, subunit
GCE56_15985	COG1271	oxidase subunit
GCE56_15990	COG0243	molybdopterin cofactor binding
GCE56_15995	COG0583	DNA-binding transcription factor activity
GCE56_16000	COG0840	transmembrane signaling receptor activity
GCE56_16005	COG0840	transmembrane signaling receptor activity
GCE56_16055	COG1358	cellular component organization or biogenesis
GCE56_16110	COG2376	Dihydroxyacetone kinase
GCE56_16115	COG1461	Dihydroxyacetone kinase
GCE56_16120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GCE56_16120	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GCE56_16120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GCE56_16130	COG4191	Histidine kinase
GCE56_16140	COG2271	Major facilitator Superfamily
GCE56_16145	COG0469	pyruvate kinase activity
GCE56_16150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GCE56_16160	COG2851	Citrate transporter
GCE56_16165	COG0813	purine-nucleoside phosphorylase activity
GCE56_16170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GCE56_16175	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GCE56_16180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GCE56_16185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GCE56_16190	COG0084	hydrolase, TatD family'
GCE56_16195	COG4667	esterase of the alpha-beta hydrolase superfamily
GCE56_16205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GCE56_16270	COG1401	restriction endodeoxyribonuclease activity
GCE56_16290	COG2003	Belongs to the UPF0758 family
GCE56_16315	COG0714	Associated with various cellular activities
GCE56_16330	COG0629	single-stranded DNA binding
GCE56_16370	COG0681	Belongs to the peptidase S26 family
GCE56_16385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCE56_16460	COG1196	nuclear chromosome segregation
GCE56_16535	COG4591	ABC-type transport system involved in lipoprotein release permease component
GCE56_16545	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
GCE56_16565	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GCE56_16590	COG5295	Hep Hag repeat protein
GCE56_16660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCE56_16695	COG3550	peptidyl-serine autophosphorylation
GCE56_16700	COG3620	sequence-specific DNA binding
GCE56_16705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GCE56_16730	COG2813	Specifically methylates the guanine in position
GCE56_16745	COG1283	sodium-dependent phosphate transmembrane transporter activity
GCE56_16755	COG0675	Transposase, IS605 OrfB family
GCE56_16765	COG2382	esterase
GCE56_16785	COG0560	Phosphoserine phosphatase
GCE56_16790	COG3726	membrane protein affecting hemolysin expression
GCE56_16795	COG1328	CTP reductase activity
GCE56_16800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCE56_16820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCE56_16835	COG1216	Glycosyl transferase, family 2
GCE56_16840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GCE56_16850	COG3260	NADH ubiquinone oxidoreductase 20
GCE56_16855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GCE56_16860	COG3261	NADH dehydrogenase
GCE56_16860	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GCE56_16865	COG0651	ATP synthesis coupled electron transport
GCE56_16870	COG4237	Hydrogenase 4 membrane
GCE56_16875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GCE56_16880	COG0650	Formate hydrogenlyase subunit 4
GCE56_16885	COG0651	ATP synthesis coupled electron transport
GCE56_16890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GCE56_16895	COG0698	ribose 5-phosphate isomerase
GCE56_16900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GCE56_16915	COG3188	usher protein
GCE56_16950	COG0702	epimerase
GCE56_16965	COG0459	protein refolding
GCE56_16970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GCE56_16985	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GCE56_16990	COG1309	transcriptional regulator
GCE56_17215	COG4771	TonB-dependent receptor
GCE56_17220	COG2814	Major facilitator Superfamily
GCE56_17230	COG3433	isochorismatase activity
GCE56_17230	COG2226	methyltransferase
GCE56_17230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GCE56_17250	COG1132	(ABC) transporter
GCE56_17320	COG3059	membrane
GCE56_17345	COG1982	Orn Lys Arg decarboxylase major
GCE56_17380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GCE56_17430	COG0305	Participates in initiation and elongation during chromosome replication
GCE56_17450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GCE56_17455	COG1704	LemA family
GCE56_17470	COG2255	four-way junction helicase activity
GCE56_17475	COG4977	sequence-specific DNA binding
GCE56_17480	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GCE56_17485	COG0644	oxidoreductase
GCE56_17490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GCE56_17495	COG2086	electron transfer activity
GCE56_17500	COG1960	acyl-CoA dehydrogenase activity
GCE56_17505	COG2610	gluconate transmembrane transporter activity
GCE56_17520	COG1924	4 iron, 4 sulfur cluster binding
GCE56_17530	COG0318	PFAM AMP-dependent synthetase and ligase
GCE56_17535	COG2271	Major facilitator Superfamily
GCE56_17540	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GCE56_17545	COG0644	oxidoreductase
GCE56_17565	COG1960	acyl-CoA dehydrogenase activity
GCE56_17570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GCE56_17575	COG0318	PFAM AMP-dependent synthetase and ligase
GCE56_17580	COG1024	Enoyl-CoA hydratase
GCE56_17600	COG3397	chitin binding
GCE56_17605	COG2137	regulation of response to DNA damage stimulus
GCE56_17625	COG2992	FlgJ-related protein
GCE56_17650	COG2610	gluconate transmembrane transporter activity
GCE56_17655	COG3265	gluconokinase activity
GCE56_17660	COG1609	Transcriptional regulator
GCE56_17675	COG1120	ATPase activity
GCE56_17680	COG0500	methyltransferase
GCE56_17685	COG0157	Belongs to the NadC ModD family
GCE56_17730	COG4790	Type iii secretion
GCE56_17775	COG2207	Transcriptional regulator
GCE56_17815	COG0789	Transcriptional regulator
GCE56_17830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GCE56_17855	COG4869	propanediol catabolic process
GCE56_17865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GCE56_17870	COG1882	Formate acetyltransferase
GCE56_17880	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GCE56_17885	COG1012	belongs to the aldehyde dehydrogenase family
GCE56_17885	COG1454	alcohol dehydrogenase
GCE56_17920	COG2873	o-acetylhomoserine
GCE56_17940	COG3188	usher protein
GCE56_17945	COG3539	Fimbrial protein
GCE56_17965	COG1177	transmembrane transport
GCE56_17990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GCE56_18010	COG1448	Aminotransferase
GCE56_18020	COG0814	amino acid
GCE56_18025	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GCE56_18035	COG0735	belongs to the Fur family
GCE56_18040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GCE56_18045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GCE56_18050	COG2937	Belongs to the GPAT DAPAT family
GCE56_18055	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GCE56_18060	COG3161	chorismate lyase activity
GCE56_18065	COG0166	Belongs to the GPI family
GCE56_18070	COG0527	aspartate kinase activity
GCE56_18085	COG1410	methionine synthase
GCE56_18085	COG0646	methionine synthase
GCE56_18095	COG0129	dihydroxy-acid dehydratase activity
GCE56_18100	COG0800	Aldolase
GCE56_18110	COG2224	Isocitrate lyase
GCE56_18115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GCE56_18120	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GCE56_18130	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GCE56_18160	COG0138	bifunctional purine biosynthesis protein purh
GCE56_18165	COG0151	Belongs to the GarS family
GCE56_18180	COG3068	Protein conserved in bacteria
GCE56_18185	COG1515	deoxyribonuclease V activity
GCE56_18190	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GCE56_18195	COG2816	NAD+ diphosphatase activity
GCE56_18205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GCE56_18210	COG0352	thiamine-phosphate diphosphorylase activity
GCE56_18215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GCE56_18220	COG2104	thiamine diphosphate biosynthetic process
GCE56_18225	COG2022	thiamine diphosphate biosynthetic process
GCE56_18235	COG5464	transposase or invertase
GCE56_18240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GCE56_18245	COG0085	RNA polymerase activity
GCE56_18250	COG0222	ribosome binding
GCE56_18255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GCE56_18260	COG0081	regulation of translation
GCE56_18265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GCE56_18270	COG0250	Participates in transcription elongation, termination and antitermination
GCE56_18285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GCE56_18290	COG0049	tRNA binding
GCE56_18295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GCE56_18305	COG2923	Belongs to the DsrF TusC family
GCE56_18310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GCE56_18315	COG2964	Protein conserved in bacteria
GCE56_18325	COG0545	Peptidyl-prolyl cis-trans isomerase
GCE56_18330	COG2900	Belongs to the SlyX family
GCE56_18335	COG1047	Peptidyl-prolyl cis-trans
GCE56_18340	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GCE56_18350	COG2249	NAD(P)H dehydrogenase (quinone) activity
GCE56_18355	COG0488	(ABC) transporter
GCE56_18360	COG0840	transmembrane signaling receptor activity
GCE56_18365	COG0840	transmembrane signaling receptor activity
GCE56_18370	COG0840	transmembrane signaling receptor activity
GCE56_18385	COG0429	hydrolase of the alpha beta-hydrolase fold
GCE56_18390	COG3089	Belongs to the UPF0270 family
GCE56_18395	COG3954	Phosphoribulokinase
GCE56_18400	COG1765	OsmC-like protein
GCE56_18405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GCE56_18410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GCE56_18420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GCE56_18430	COG0242	peptide deformylase activity
GCE56_18435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GCE56_18435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GCE56_18445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GCE56_18450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GCE56_18455	COG3084	Protein conserved in bacteria
GCE56_18460	COG0746	molybdenum cofactor guanylyltransferase activity
GCE56_18465	COG1763	Mo-molybdopterin cofactor biosynthetic process
GCE56_18480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GCE56_18485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GCE56_18495	COG1295	ribonuclease BN
GCE56_18500	COG1942	4-Oxalocrotonate Tautomerase
GCE56_18510	COG2199	diguanylate cyclase activity
GCE56_18510	COG2200	EAL domain
GCE56_18515	COG3210	domain, Protein
GCE56_18520	COG4608	Belongs to the ABC transporter superfamily
GCE56_18525	COG0444	Belongs to the ABC transporter superfamily
GCE56_18530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GCE56_18535	COG0601	transmembrane transport
GCE56_18540	COG0747	negative chemotaxis
GCE56_18545	COG2831	hemolysin activation secretion protein
GCE56_18560	COG5645	(Lipo)protein
GCE56_18565	COG2985	domain, Protein
GCE56_18565	COG0569	domain protein
GCE56_18570	COG3977	Valine--pyruvate aminotransferase
GCE56_18575	COG2818	Glycosylase
GCE56_18580	COG0752	glycyl-tRNA synthetase alpha subunit
GCE56_18585	COG0751	glycine-tRNA ligase activity
GCE56_18610	COG0823	Involved in the tonB-independent uptake of proteins
GCE56_18615	COG2860	membrane
GCE56_18620	COG0194	GDP metabolic process
GCE56_18625	COG1758	RNA polymerase activity
GCE56_18630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GCE56_18635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GCE56_18640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GCE56_18645	COG0786	glutamate:sodium symporter activity
GCE56_18650	COG2233	PERMEase
GCE56_18660	COG2982	Protein involved in outer membrane biogenesis
GCE56_18670	COG1187	pseudouridine synthase activity
GCE56_18675	COG0456	acetyltransferase
GCE56_18680	COG1490	D-aminoacyl-tRNA deacylase activity
GCE56_18685	COG1011	Hydrolase
GCE56_18750	COG2183	response to ionizing radiation
GCE56_18755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GCE56_18760	COG0745	RESPONSE REGULATOR receiver
GCE56_18765	COG2205	protein histidine kinase activity
GCE56_18770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GCE56_18775	COG0573	inorganic phosphate transmembrane transporter activity
GCE56_18780	COG0581	inorganic phosphate transmembrane transporter activity
GCE56_18790	COG0704	Plays a role in the regulation of phosphate uptake
GCE56_18795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GCE56_18805	COG0765	amino acid transport
GCE56_18830	COG1136	(ABC) transporter
GCE56_18845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GCE56_18850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GCE56_18855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GCE56_18860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GCE56_18865	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_18870	COG0736	holo-[acyl-carrier-protein] synthase activity
GCE56_18880	COG2252	PERMEase
GCE56_18885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GCE56_18905	COG1918	ferrous iron import across plasma membrane
GCE56_18910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GCE56_18925	COG2267	carboxylic ester hydrolase activity
GCE56_18930	COG1040	competence protein
GCE56_18935	COG0316	Belongs to the HesB IscA family
GCE56_18935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GCE56_18940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GCE56_18945	COG0705	Rhomboid family
GCE56_18950	COG1349	DNA-binding transcription factor activity
GCE56_18955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GCE56_18960	COG3189	MarR family transcriptional regulator
GCE56_19000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GCE56_19020	COG1124	(ABC) transporter
GCE56_19035	COG0601	transmembrane transport
GCE56_19040	COG0747	negative chemotaxis
GCE56_19045	COG1073	alpha beta
GCE56_19045	COG2226	methyltransferase
GCE56_19060	COG3394	polysaccharide catabolic process
GCE56_19065	COG1486	melibiose metabolic process
GCE56_19070	COG2169	Transcriptional regulator
GCE56_19070	COG1917	Cupin 2, conserved barrel domain protein
GCE56_19075	COG1447	Phosphotransferase system cellobiose-specific component IIA
GCE56_19080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GCE56_19085	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GCE56_19090	COG4607	ABC-type enterochelin transport system periplasmic component
GCE56_19095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GCE56_19100	COG4605	iron ion homeostasis
GCE56_19105	COG4604	ABC transporter, ATP-binding protein
GCE56_19125	COG0243	molybdopterin cofactor binding
GCE56_19130	COG0437	4 iron, 4 sulfur cluster binding
GCE56_19135	COG3302	dmso reductase anchor subunit
GCE56_19140	COG1609	Transcriptional regulator
GCE56_19150	COG2211	Major facilitator Superfamily
GCE56_19155	COG1285	pathogenesis
GCE56_19160	COG2755	lipolytic protein G-D-S-L family
GCE56_19160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GCE56_19175	COG1737	Transcriptional regulator
GCE56_19180	COG2731	YhcH YjgK YiaL family protein
GCE56_19185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCE56_19195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GCE56_19200	COG3383	formate dehydrogenase (NAD+) activity
GCE56_19205	COG0733	neurotransmitter:sodium symporter activity
GCE56_19210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GCE56_19215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GCE56_19215	COG1263	PTS System
GCE56_19220	COG1737	Transcriptional regulator
GCE56_19225	COG1278	Cold shock
GCE56_19230	COG0564	pseudouridine synthase activity
GCE56_19235	COG3122	Protein conserved in bacteria
GCE56_19245	COG0675	Transposase, IS605 OrfB family
GCE56_19260	COG3501	Rhs element vgr protein
GCE56_19300	COG3188	usher protein
GCE56_19360	COG2003	Belongs to the UPF0758 family
GCE56_19390	COG3468	outer membrane autotransporter barrel domain protein
GCE56_19470	COG4372	Transposase
GCE56_19475	COG3436	PFAM IS66 Orf2 family protein
GCE56_19485	COG3039	Transposase
GCE56_19620	COG1660	Displays ATPase and GTPase activities
GCE56_19730	COG3300	MHYT domain
GCE56_19730	COG5001	Diguanylate cyclase
GCE56_19795	COG0582	viral genome integration into host DNA
GCE56_19810	COG0742	ribosomal rna small subunit methyltransferase
GCE56_19815	COG1028	Short-chain dehydrogenase reductase Sdr
GCE56_19825	COG0589	response to stress
GCE56_19835	COG0306	phosphate transporter
GCE56_19840	COG2081	HI0933 family
GCE56_19860	COG1741	Belongs to the pirin family
GCE56_19865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GCE56_19870	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GCE56_19875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GCE56_19885	COG0494	nUDIX hydrolase
GCE56_19895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GCE56_19915	COG4796	Type ii and iii secretion system protein
GCE56_19920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GCE56_19925	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GCE56_19940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GCE56_19945	COG0546	phosphoglycolate phosphatase activity
GCE56_19950	COG0180	Tryptophanyl-tRNA synthetase
GCE56_19965	COG2258	MOSC domain
GCE56_19970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GCE56_19975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GCE56_19980	COG3162	membrane
GCE56_19985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GCE56_19990	COG2194	sulfuric ester hydrolase activity
GCE56_19995	COG0675	Transposase, IS605 OrfB family
GCE56_20005	COG1556	Lactate utilization protein
GCE56_20010	COG1139	Iron-sulfur cluster binding protein
GCE56_20015	COG0247	lactate metabolic process
GCE56_20040	COG2186	Transcriptional regulator
GCE56_20045	COG0477	Major facilitator Superfamily
GCE56_20050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GCE56_20055	COG0714	Associated with various cellular activities
GCE56_20060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GCE56_20065	COG2502	aspartate--ammonia ligase
GCE56_20070	COG1522	sequence-specific DNA binding
GCE56_20075	COG0716	FMN binding
GCE56_20080	COG0445	tRNA wobble uridine modification
GCE56_20085	COG0357	Ribosomal RNA small subunit methyltransferase G
GCE56_20090	COG3312	ion transport
GCE56_20095	COG0356	it plays a direct role in the translocation of protons across the membrane
GCE56_20105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GCE56_20110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GCE56_20115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GCE56_20120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GCE56_20125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GCE56_20130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GCE56_20135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GCE56_20140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GCE56_20220	COG3842	ATPase activity
GCE56_20225	COG1178	ABC-type Fe3 transport system permease component
GCE56_20230	COG1840	ABC-type Fe3 transport system, periplasmic component
GCE56_20235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GCE56_20250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GCE56_20260	COG1288	antiporter activity
GCE56_20295	COG3188	usher protein
GCE56_20320	COG3111	PFAM Bacterial OB fold (BOF) protein
GCE56_20330	COG1940	carbohydrate kinase activity
GCE56_20340	COG1215	transferase activity, transferring glycosyl groups
GCE56_20350	COG0457	Tetratricopeptide repeat
GCE56_20360	COG3706	GGDEF domain
GCE56_20365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GCE56_20370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GCE56_20375	COG1368	sulfuric ester hydrolase activity
GCE56_20380	COG3276	selenocysteine insertion sequence binding
GCE56_20385	COG1921	L-seryl-tRNASec selenium transferase activity
GCE56_20390	COG3058	Necessary for formate dehydrogenase activity
GCE56_20395	COG2864	formate dehydrogenase
GCE56_20400	COG0437	4 iron, 4 sulfur cluster binding
GCE56_20410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GCE56_20430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GCE56_20435	COG0583	DNA-binding transcription factor activity
GCE56_20475	COG3550	peptidyl-serine autophosphorylation
GCE56_20485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GCE56_20490	COG0706	membrane insertase activity
GCE56_20495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GCE56_20500	COG0594	ribonuclease P activity
GCE56_20505	COG0230	Belongs to the bacterial ribosomal protein bL34 family