locus-tag	class	description
GO498_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO498_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO498_00020	COG0187	DNA topoisomerase II activity
GO498_00025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO498_00030	COG4106	trans-aconitate 2-methyltransferase activity
GO498_00035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO498_00055	COG1561	YicC-like family, N-terminal region
GO498_00060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO498_00065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO498_00070	COG1309	transcriptional regulator
GO498_00075	COG0756	dUTP diphosphatase activity
GO498_00080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO498_00085	COG2003	Belongs to the UPF0758 family
GO498_00090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO498_00095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO498_00100	COG0438	transferase activity, transferring glycosyl groups
GO498_00110	COG0297	glycogen (starch) synthase activity
GO498_00125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO498_00130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO498_00140	COG1519	Transferase
GO498_00145	COG0859	PFAM glycosyl transferase family 9
GO498_00150	COG0438	transferase activity, transferring glycosyl groups
GO498_00155	COG0438	transferase activity, transferring glycosyl groups
GO498_00165	COG0859	PFAM glycosyl transferase family 9
GO498_00170	COG1216	Glycosyl transferase, family 2
GO498_00170	COG1442	glycosyl transferase family 8
GO498_00175	COG0859	PFAM glycosyl transferase family 9
GO498_00180	COG0859	PFAM glycosyl transferase family 9
GO498_00185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO498_00190	COG0156	8-amino-7-oxononanoate synthase activity
GO498_00195	COG1063	alcohol dehydrogenase
GO498_00200	COG2861	carbohydrate metabolic process
GO498_00205	COG4942	peptidase
GO498_00210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO498_00220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO498_00225	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GO498_00235	COG1045	serine acetyltransferase
GO498_00240	COG1045	serine acetyltransferase
GO498_00245	COG1216	Glycosyl transferase, family 2
GO498_00250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO498_00270	COG1216	Glycosyl transferase, family 2
GO498_00290	COG1216	Glycosyl transferase, family 2
GO498_00295	COG2205	protein histidine kinase activity
GO498_00300	COG0745	RESPONSE REGULATOR receiver
GO498_00305	COG3678	ATP-independent chaperone mediated protein folding
GO498_00310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GO498_00380	COG4695	Portal protein
GO498_00465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
GO498_00520	COG2194	sulfuric ester hydrolase activity
GO498_00525	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_00530	COG0205	6-phosphofructokinase activity
GO498_00535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GO498_00540	COG0149	triose-phosphate isomerase activity
GO498_00550	COG3152	Membrane
GO498_00555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO498_00560	COG2814	Major facilitator Superfamily
GO498_00565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO498_00575	COG3074	FtsZ-dependent cytokinesis
GO498_00580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO498_00585	COG1575	Belongs to the MenA family. Type 1 subfamily
GO498_00590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO498_00595	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO498_00600	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO498_00605	COG1609	Transcriptional regulator
GO498_00610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO498_00615	COG0254	rRNA binding
GO498_00620	COG3550	peptidyl-serine autophosphorylation
GO498_00625	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GO498_00630	COG0626	cystathionine gamma-synthase activity
GO498_00635	COG0460	homoserine dehydrogenase
GO498_00635	COG0527	aspartate kinase activity
GO498_00640	COG2862	Uncharacterized protein family, UPF0114
GO498_00650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GO498_00655	COG1216	Glycosyl transferase, family 2
GO498_00665	COG0477	Major facilitator Superfamily
GO498_00670	COG0583	DNA-binding transcription factor activity
GO498_00690	COG0028	Belongs to the TPP enzyme family
GO498_00695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO498_00700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO498_00705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO498_00710	COG0137	argininosuccinate synthase activity
GO498_00715	COG0165	Argininosuccinate lyase
GO498_00725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO498_00740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO498_00745	COG4206	TonB-dependent receptor
GO498_00750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO498_00785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO498_00795	COG1072	(Pantothenic acid kinase))
GO498_00840	COG0051	transcription antitermination factor activity, RNA binding
GO498_00845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO498_00850	COG0088	Forms part of the polypeptide exit tunnel
GO498_00855	COG0089	rRNA binding
GO498_00860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO498_00865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GO498_00870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GO498_00880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GO498_00885	COG0255	Belongs to the universal ribosomal protein uL29 family
GO498_00890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO498_00895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO498_00900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GO498_00905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO498_00910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO498_00915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO498_00920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO498_00925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO498_00930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO498_00935	COG1841	ribosomal large subunit assembly
GO498_00940	COG0200	Binds to the 23S rRNA
GO498_00945	COG0201	protein transport
GO498_00950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO498_00955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO498_00965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO498_00975	COG0203	ribosomal protein L17
GO498_00980	COG0789	Transcriptional regulator
GO498_00985	COG3036	rescue of stalled ribosome
GO498_00990	COG1970	mechanosensitive ion channel activity
GO498_00995	COG0569	domain protein
GO498_01000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO498_01000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO498_01005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO498_01010	COG0242	peptide deformylase activity
GO498_01015	COG0758	DNA mediated transformation
GO498_01020	COG0551	DNA topoisomerase type I activity
GO498_01025	COG0009	L-threonylcarbamoyladenylate synthase
GO498_01030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO498_01040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO498_01080	COG0583	DNA-binding transcription factor activity
GO498_01085	COG3085	chromosome segregation
GO498_01090	COG0606	chelatase, subunit chli
GO498_01105	COG3978	acetolactate synthase activity
GO498_01110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO498_01115	COG0129	dihydroxy-acid dehydratase activity
GO498_01125	COG0583	DNA-binding transcription factor activity
GO498_01130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GO498_01135	COG3041	Addiction module toxin RelE StbE family
GO498_01145	COG0210	DNA helicase
GO498_01150	COG0248	Ppx GppA phosphatase
GO498_01155	COG0513	Belongs to the DEAD box helicase family
GO498_01160	COG3118	belongs to the thioredoxin family
GO498_01165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO498_01170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO498_01180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GO498_01185	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GO498_01190	COG1088	dTDP-glucose 4,6-dehydratase activity
GO498_01195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GO498_01200	COG0456	acetyltransferase
GO498_01205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO498_01210	COG2244	polysaccharide biosynthetic process
GO498_01215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO498_01225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GO498_01255	COG3071	HemY protein
GO498_01260	COG2959	enzyme of heme biosynthesis
GO498_01280	COG1965	Belongs to the frataxin family
GO498_01285	COG5567	small periplasmic lipoprotein
GO498_01290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO498_01305	COG1011	Hydrolase
GO498_01310	COG0210	DNA helicase
GO498_01320	COG2962	Rard protein
GO498_01325	COG2050	protein possibly involved in aromatic compounds catabolism
GO498_01340	COG2267	carboxylic ester hydrolase activity
GO498_01345	COG0561	phosphatase activity
GO498_01355	COG3188	usher protein
GO498_01360	COG3121	Chaperone
GO498_01365	COG3539	Fimbrial protein
GO498_01375	COG1511	domain protein
GO498_01375	COG3264	Mechanosensitive ion channel
GO498_01380	COG0688	phosphatidylethanolamine metabolic process
GO498_01385	COG1162	GTPase activity
GO498_01390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GO498_01420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO498_01425	COG0802	atpase or kinase
GO498_01430	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO498_01435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO498_01440	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO498_01445	COG1923	regulation of RNA biosynthetic process
GO498_01450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO498_01455	COG0330	HflC and HflK could
GO498_01460	COG0330	HflC and HflK could
GO498_01465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GO498_01470	COG1959	2 iron, 2 sulfur cluster binding
GO498_01475	COG0557	exoribonuclease II activity
GO498_01480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO498_01485	COG0360	Binds together with S18 to 16S ribosomal RNA
GO498_01490	COG2965	DNA replication, synthesis of RNA primer
GO498_01500	COG0359	binds to the 23S rRNA
GO498_01505	COG3061	Opacity-associated protein A
GO498_01510	COG0254	rRNA binding
GO498_01515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO498_01520	COG3443	Belongs to the bacterial solute-binding protein 9 family
GO498_01530	COG0675	Transposase, IS605 OrfB family
GO498_01535	COG1012	belongs to the aldehyde dehydrogenase family
GO498_01540	COG0545	Peptidyl-prolyl cis-trans isomerase
GO498_01550	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GO498_01560	COG1253	flavin adenine dinucleotide binding
GO498_01565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO498_01570	COG0729	surface antigen
GO498_01575	COG2911	Protein conserved in bacteria
GO498_01580	COG2105	PFAM AIG2 family protein
GO498_01600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO498_01605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GO498_01610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO498_01615	COG1438	arginine binding
GO498_01620	COG0039	L-malate dehydrogenase activity
GO498_01625	COG3423	Transcriptional regulator
GO498_01640	COG0142	geranyltranstransferase activity
GO498_01645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO498_01650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO498_01655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO498_01660	COG2027	D-alanyl-D-alanine carboxypeptidase
GO498_01665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO498_01670	COG1534	Rna-binding protein
GO498_01675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GO498_01680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO498_01685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO498_01690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO498_01695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO498_01710	COG0779	Required for maturation of 30S ribosomal subunits
GO498_01715	COG0195	Participates in both transcription termination and antitermination
GO498_01720	COG3064	Membrane
GO498_01720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO498_01725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO498_01730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO498_01735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO498_01740	COG1185	polyribonucleotide nucleotidyltransferase activity
GO498_01750	COG0513	Belongs to the DEAD box helicase family
GO498_01755	COG2964	Protein conserved in bacteria
GO498_01765	COG0251	oxidation-reduction process
GO498_01770	COG2271	Major facilitator Superfamily
GO498_01795	COG3275	phosphorelay sensor kinase activity
GO498_01800	COG1566	PFAM secretion protein HlyD family protein
GO498_01815	COG3539	Fimbrial protein
GO498_01820	COG3121	Chaperone
GO498_01825	COG3188	usher protein
GO498_01830	COG3539	Fimbrial protein
GO498_01835	COG3539	Fimbrial protein
GO498_01840	COG3539	Fimbrial protein
GO498_01860	COG3153	acetyltransferase
GO498_01865	COG2827	Endonuclease containing a URI domain
GO498_01890	COG0602	queuosine metabolic process
GO498_01895	COG1328	CTP reductase activity
GO498_01905	COG0251	oxidation-reduction process
GO498_01910	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GO498_01915	COG0540	Belongs to the ATCase OTCase family
GO498_01925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO498_01935	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GO498_01950	COG0456	acetyltransferase
GO498_01955	COG0525	valine-tRNA ligase activity
GO498_01960	COG2927	DNA polymerase III (CHI subunit)
GO498_01965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO498_01970	COG0795	lipopolysaccharide-transporting ATPase activity
GO498_01975	COG0795	lipopolysaccharide-transporting ATPase activity
GO498_01980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO498_01990	COG0582	viral genome integration into host DNA
GO498_02035	COG0675	Transposase, IS605 OrfB family
GO498_02050	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GO498_02055	COG1690	Belongs to the RtcB family
GO498_02060	COG1349	DNA-binding transcription factor activity
GO498_02065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO498_02070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_02075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO498_02080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_02080	COG1263	PTS System
GO498_02100	COG0028	Belongs to the TPP enzyme family
GO498_02105	COG0440	acetolactate synthase activity
GO498_02125	COG2252	PERMEase
GO498_02130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO498_02135	COG0025	NhaP-type Na H and K H
GO498_02140	COG0697	spore germination
GO498_02145	COG0583	DNA-binding transcription factor activity
GO498_02150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO498_02160	COG3753	Protein conserved in bacteria
GO498_02165	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GO498_02175	COG0586	Pfam SNARE associated Golgi protein
GO498_02180	COG1322	Protein conserved in bacteria
GO498_02185	COG2226	methyltransferase
GO498_02190	COG3165	ubiquinone biosynthetic process from chorismate
GO498_02200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO498_02205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO498_02210	COG0805	protein transport
GO498_02225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO498_02235	COG0183	Belongs to the thiolase family
GO498_02240	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO498_02240	COG1024	Enoyl-CoA hydratase
GO498_02245	COG0006	proline dipeptidase activity
GO498_02250	COG1739	Uncharacterized protein family UPF0029
GO498_02255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO498_02290	COG1914	H( )-stimulated, divalent metal cation uptake system
GO498_02295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GO498_02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GO498_02305	COG4770	biotin carboxylase activity
GO498_02310	COG0730	response to heat
GO498_02325	COG0583	DNA-binding transcription factor activity
GO498_02330	COG2197	response regulator
GO498_02335	COG3850	Histidine kinase
GO498_02340	COG2223	nitrite transmembrane transporter activity
GO498_02345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GO498_02350	COG1140	nitrate reductase beta subunit
GO498_02355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GO498_02360	COG2181	nitrate reductase activity
GO498_02365	COG1304	FMN binding
GO498_02370	COG2194	sulfuric ester hydrolase activity
GO498_02385	COG3604	Transcriptional regulator
GO498_02390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO498_02395	COG0375	protein maturation
GO498_02400	COG0298	carbon dioxide binding
GO498_02405	COG2076	Multidrug Resistance protein
GO498_02410	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO498_02415	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GO498_02420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO498_02425	COG1053	succinate dehydrogenase
GO498_02430	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GO498_02435	COG0584	glycerophosphoryl diester phosphodiesterase
GO498_02440	COG2271	Major facilitator Superfamily
GO498_02445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO498_02455	COG0247	lactate metabolic process
GO498_02465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO498_02475	COG0425	Belongs to the sulfur carrier protein TusA family
GO498_02485	COG0675	Transposase, IS605 OrfB family
GO498_02500	COG2217	Heavy metal translocating P-type atpase
GO498_02505	COG3714	YhhN family
GO498_02515	COG3776	membrane
GO498_02520	COG0742	ribosomal rna small subunit methyltransferase
GO498_02525	COG0552	protein localization to endoplasmic reticulum
GO498_02530	COG2884	Cell division ATP-binding protein ftsE
GO498_02535	COG2177	Part of the ABC transporter FtsEX involved in
GO498_02545	COG1929	Belongs to the glycerate kinase type-1 family
GO498_02555	COG2814	Major facilitator Superfamily
GO498_02560	COG1846	Transcriptional regulator
GO498_02565	COG0501	Belongs to the peptidase M48B family
GO498_02570	COG3842	ATPase activity
GO498_02575	COG0395	ABC-type sugar transport system, permease component
GO498_02585	COG1653	transport
GO498_02590	COG0584	glycerophosphoryl diester phosphodiesterase
GO498_02595	COG2807	transmembrane transport
GO498_02625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO498_02630	COG2264	protein methyltransferase activity
GO498_02635	COG4145	pantothenate transmembrane transporter activity
GO498_02640	COG3924	membrane
GO498_02645	COG0439	Biotin carboxylase
GO498_02650	COG0511	ligase activity, forming carbon-carbon bonds
GO498_02655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO498_02660	COG0604	alcohol dehydrogenase
GO498_02665	COG1077	Cell shape determining protein MreB Mrl
GO498_02670	COG1792	Involved in formation and maintenance of cell shape
GO498_02675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO498_02680	COG0424	maF-like protein
GO498_02685	COG1530	ribonuclease E activity
GO498_02690	COG3164	Protein of unknown function
GO498_02695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO498_02700	COG0312	modulator of DNA gyrase
GO498_02710	COG2732	(Barnase) inhibitor
GO498_02715	COG3028	Belongs to the UPF0307 family
GO498_02720	COG0312	modulator of DNA gyrase
GO498_02725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO498_02730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO498_02735	COG1660	Displays ATPase and GTPase activities
GO498_02740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO498_02745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO498_02750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO498_02755	COG1137	ATPase activity
GO498_02760	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GO498_02765	COG3117	lipopolysaccharide transmembrane transporter activity
GO498_02770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GO498_02775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO498_02775	COG0517	IMP dehydrogenase activity
GO498_02780	COG0530	calcium, potassium:sodium antiporter activity
GO498_02785	COG1127	ABC transporter
GO498_02790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO498_02795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO498_02800	COG2854	intermembrane phospholipid transfer
GO498_02810	COG5007	Belongs to the BolA IbaG family
GO498_02815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO498_02825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO498_02830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO498_02835	COG3105	Protein conserved in bacteria
GO498_02840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO498_02845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO498_02850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO498_02855	COG0625	glutathione transferase activity
GO498_02860	COG2969	positive regulation of protein catabolic process
GO498_02870	COG1473	amidohydrolase
GO498_02875	COG3069	C4-dicarboxylate transmembrane transporter activity
GO498_02880	COG0493	'glutamate synthase
GO498_02885	COG0067	glutamate synthase
GO498_02885	COG0069	glutamate synthase activity
GO498_02885	COG0070	glutamate synthase
GO498_02890	COG0784	Response regulator, receiver
GO498_02890	COG2198	Histidine kinase
GO498_02890	COG5002	protein histidine kinase activity
GO498_02895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GO498_02900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO498_02905	COG2207	Transcriptional regulator
GO498_02910	COG0829	nickel cation binding
GO498_02915	COG0831	urea catabolic process
GO498_02920	COG0832	Belongs to the urease beta subunit family
GO498_02925	COG0804	urea catabolic process
GO498_02930	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GO498_02935	COG0830	nickel cation binding
GO498_02940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GO498_02945	COG2823	Periplasmic or secreted lipoprotein
GO498_02950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO498_02955	COG0792	nuclease activity
GO498_02965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO498_02975	COG1741	Belongs to the pirin family
GO498_02980	COG0583	DNA-binding transcription factor activity
GO498_02985	COG2259	Doxx family
GO498_02995	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
GO498_03000	COG4575	ribosome binding
GO498_03005	COG0586	Pfam SNARE associated Golgi protein
GO498_03010	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GO498_03015	COG1902	pentaerythritol trinitrate reductase activity
GO498_03015	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO498_03025	COG0612	Peptidase, M16
GO498_03030	COG4178	(ABC) transporter
GO498_03035	COG4771	TonB-dependent receptor
GO498_03045	COG1595	DNA-templated transcription, initiation
GO498_03055	COG0488	(ABC) transporter
GO498_03060	COG0741	lytic transglycosylase activity
GO498_03065	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GO498_03070	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GO498_03075	COG0406	alpha-ribazole phosphatase activity
GO498_03080	COG3708	Transcriptional regulator
GO498_03080	COG2207	Transcriptional regulator
GO498_03085	COG3045	CreA protein
GO498_03090	COG0745	RESPONSE REGULATOR receiver
GO498_03100	COG0083	homoserine kinase activity
GO498_03115	COG3022	response to hydroperoxide
GO498_03120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO498_03130	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO498_03135	COG0443	Heat shock 70 kDa protein
GO498_03140	COG0484	heat shock protein binding
GO498_03145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO498_03150	COG0583	DNA-binding transcription factor activity
GO498_03155	COG0268	Binds directly to 16S ribosomal RNA
GO498_03165	COG0196	riboflavin kinase activity
GO498_03170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO498_03175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO498_03180	COG1047	Peptidyl-prolyl cis-trans
GO498_03185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO498_03190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO498_03195	COG0505	Belongs to the CarA family
GO498_03220	COG1979	alcohol dehydrogenase
GO498_03225	COG2226	methyltransferase
GO498_03230	COG0586	Pfam SNARE associated Golgi protein
GO498_03235	COG0626	cystathionine gamma-synthase activity
GO498_03240	COG0811	peptide transport
GO498_03245	COG0848	biopolymer transport protein
GO498_03250	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GO498_03255	COG0437	4 iron, 4 sulfur cluster binding
GO498_03260	COG5557	Pfam Polysulphide reductase, NrfD
GO498_03265	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GO498_03270	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO498_03275	COG1773	rubredoxin
GO498_03280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GO498_03285	COG0298	carbon dioxide binding
GO498_03290	COG0409	Hydrogenase expression formation protein
GO498_03295	COG0309	Hydrogenase expression formation protein (HypE)
GO498_03300	COG2391	methyltransferase activity
GO498_03305	COG0425	Belongs to the sulfur carrier protein TusA family
GO498_03310	COG2974	May be involved in recombination
GO498_03320	COG0737	Belongs to the 5'-nucleotidase family
GO498_03325	COG3719	Belongs to the RNase T2 family
GO498_03330	COG0737	Belongs to the 5'-nucleotidase family
GO498_03345	COG0419	ATPase involved in DNA repair
GO498_03350	COG0420	3'-5' exonuclease activity
GO498_03360	COG5002	protein histidine kinase activity
GO498_03365	COG1114	Component of the transport system for branched-chain amino acids
GO498_03410	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GO498_03415	COG0437	4 iron, 4 sulfur cluster binding
GO498_03425	COG2414	aldehyde ferredoxin oxidoreductase
GO498_03430	COG0437	4 iron, 4 sulfur cluster binding
GO498_03440	COG0450	alkyl hydroperoxide reductase
GO498_03445	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GO498_03450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO498_03455	COG0343	queuine tRNA-ribosyltransferase activity
GO498_03460	COG1862	Preprotein translocase
GO498_03465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO498_03470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO498_03475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO498_03480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO498_03480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO498_03485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO498_03490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO498_03500	COG2824	Alkylphosphonate utilization operon protein PhnA
GO498_03515	COG1609	Transcriptional regulator
GO498_03520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_03525	COG1879	ABC-type sugar transport system periplasmic component
GO498_03530	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO498_03535	COG1129	ABC transporter
GO498_03540	COG1869	D-ribose catabolic process
GO498_03545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO498_03550	COG0142	geranyltranstransferase activity
GO498_03560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO498_03560	COG0301	tRNA thio-modification
GO498_03570	COG0693	protein deglycase activity
GO498_03575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO498_03580	COG1666	GTP binding
GO498_03585	COG2814	Major facilitator Superfamily
GO498_03590	COG0109	protoheme IX farnesyltransferase activity
GO498_03595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO498_03600	COG1845	cytochrome c oxidase, subunit III
GO498_03605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO498_03610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO498_03620	COG0513	Belongs to the DEAD box helicase family
GO498_03625	COG2223	nitrite transmembrane transporter activity
GO498_03630	COG3056	Lipoprotein
GO498_03635	COG0271	Belongs to the BolA IbaG family
GO498_03640	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO498_03645	COG0740	serine-type endopeptidase activity
GO498_03650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO498_03655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO498_03660	COG0776	regulation of translation
GO498_03665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO498_03670	COG1596	polysaccharide export
GO498_03670	COG1555	photosystem II stabilization
GO498_03675	COG0824	Thioesterase
GO498_03680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO498_03685	COG1522	sequence-specific DNA binding
GO498_03690	COG1132	(ABC) transporter
GO498_03695	COG1132	(ABC) transporter
GO498_03700	COG0347	Belongs to the P(II) protein family
GO498_03705	COG0004	ammonium transporteR
GO498_03710	COG1946	Acyl-CoA thioesterase
GO498_03730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO498_03735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO498_03740	COG1309	transcriptional regulator
GO498_03745	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GO498_03750	COG3264	Mechanosensitive ion channel
GO498_03750	COG1196	nuclear chromosome segregation
GO498_03765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO498_03775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO498_03780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO498_03785	COG1966	Carbon starvation protein
GO498_03790	COG2879	small protein
GO498_03795	COG0523	cobalamin synthesis protein
GO498_03805	COG3069	C4-dicarboxylate transmembrane transporter activity
GO498_03810	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO498_03820	COG0534	Mate efflux family protein
GO498_03825	COG0673	inositol 2-dehydrogenase activity
GO498_03830	COG5564	TIM-barrel signal transduction protein
GO498_03835	COG5441	Belongs to the UPF0261 family
GO498_03870	COG2132	Multicopper oxidase
GO498_03880	COG0288	reversible hydration of carbon dioxide
GO498_03885	COG1131	(ABC) transporter
GO498_03890	COG0842	Transport permease protein
GO498_03895	COG0477	Major facilitator Superfamily
GO498_03905	COG0501	Belongs to the peptidase M48B family
GO498_03920	COG0437	4 iron, 4 sulfur cluster binding
GO498_03925	COG0243	molybdopterin cofactor binding
GO498_03935	COG2837	iron assimilation
GO498_03950	COG4633	Protein conserved in bacteria
GO498_03960	COG2963	transposase activity
GO498_03965	COG3157	Type VI secretion system effector, Hcp
GO498_03980	COG0754	glutathionylspermidine amidase activity
GO498_03985	COG0583	DNA-binding transcription factor activity
GO498_03990	COG2610	gluconate transmembrane transporter activity
GO498_03995	COG3048	D-serine ammonia-lyase activity
GO498_04000	COG3842	ATPase activity
GO498_04010	COG1840	ABC-type Fe3 transport system, periplasmic component
GO498_04015	COG2271	Major facilitator Superfamily
GO498_04020	COG3851	Histidine kinase
GO498_04030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GO498_04035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO498_04040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO498_04045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO498_04060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO498_04065	COG1489	DNA binding
GO498_04070	COG1643	Atp-dependent helicase
GO498_04075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO498_04080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO498_04085	COG0316	Belongs to the HesB IscA family
GO498_04095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO498_04105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO498_04110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO498_04115	COG3956	TIGRFAM MazG family protein
GO498_04125	COG0504	CTP synthase activity
GO498_04130	COG0148	phosphopyruvate hydratase activity
GO498_04135	COG0471	metal ion transport
GO498_04145	COG0741	lytic transglycosylase activity
GO498_04145	COG1388	LysM domain
GO498_04150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO498_04155	COG2226	methyltransferase
GO498_04160	COG0328	RNA-DNA hybrid ribonuclease activity
GO498_04165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO498_04200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO498_04205	COG1120	ATPase activity
GO498_04215	COG4264	IucA IucC family
GO498_04225	COG0019	diaminopimelate decarboxylase activity
GO498_04230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO498_04235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO498_04240	COG2814	Major facilitator Superfamily
GO498_04255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO498_04260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO498_04265	COG0126	phosphoglycerate kinase activity
GO498_04275	COG2314	TM2 domain
GO498_04280	COG3104	oligopeptide transport
GO498_04295	COG1846	Transcriptional regulator
GO498_04300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO498_04315	COG1234	tRNA 3'-trailer cleavage
GO498_04320	COG3539	Fimbrial protein
GO498_04325	COG3188	usher protein
GO498_04330	COG3121	Chaperone
GO498_04335	COG3539	Fimbrial protein
GO498_04340	COG3539	Fimbrial protein
GO498_04360	COG0582	viral genome integration into host DNA
GO498_04365	COG3539	Fimbrial protein
GO498_04375	COG3188	usher protein
GO498_04380	COG3121	Chaperone
GO498_04395	COG3539	Fimbrial protein
GO498_04410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GO498_04420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO498_04425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO498_04480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO498_04485	COG1554	hydrolase, family 65, central catalytic
GO498_04490	COG1263	PTS System
GO498_04490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_04555	COG2207	Transcriptional regulator
GO498_04555	COG3708	Transcriptional regulator
GO498_04585	COG2274	protein secretion by the type I secretion system
GO498_04595	COG1309	transcriptional regulator
GO498_04600	COG0531	amino acid
GO498_04605	COG1982	Orn Lys Arg decarboxylase major
GO498_04645	COG0305	Participates in initiation and elongation during chromosome replication
GO498_04825	COG2831	hemolysin activation secretion protein
GO498_04830	COG3210	domain, Protein
GO498_04935	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GO498_04945	COG0741	lytic transglycosylase activity
GO498_04950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GO498_04955	COG1194	a g-specific adenine glycosylase
GO498_04965	COG3171	Protein conserved in bacteria
GO498_04970	COG2066	Belongs to the glutaminase family
GO498_04980	COG4607	ABC-type enterochelin transport system periplasmic component
GO498_04985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO498_04990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO498_04995	COG0762	integral membrane protein
GO498_05000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO498_05005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO498_05010	COG2805	Type II/IV secretion system protein
GO498_05015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO498_05020	COG1678	Uncharacterized ACR, COG1678
GO498_05025	COG0189	ligase activity
GO498_05030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO498_05055	COG0583	DNA-binding transcription factor activity
GO498_05060	COG0019	diaminopimelate decarboxylase activity
GO498_05065	COG1960	acyl-CoA dehydrogenase activity
GO498_05070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GO498_05075	COG0121	glutamine amidotransferase
GO498_05080	COG3034	peptidoglycan biosynthetic process
GO498_05085	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO498_05090	COG1805	sodium ion transport
GO498_05095	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO498_05100	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO498_05105	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GO498_05110	COG2871	sodium ion transport
GO498_05115	COG1477	protein flavinylation
GO498_05120	COG2991	Protein conserved in bacteria
GO498_05125	COG3237	CsbD-like
GO498_05135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO498_05140	COG4774	siderophore transport
GO498_05145	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO498_05150	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GO498_05165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO498_05170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO498_05175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO498_05180	COG0318	PFAM AMP-dependent synthetase and ligase
GO498_05180	COG0204	Acyl-transferase
GO498_05185	COG2814	Major facilitator Superfamily
GO498_05190	COG1546	Belongs to the CinA family
GO498_05195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO498_05200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO498_05205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GO498_05235	COG2918	glutathione biosynthetic process
GO498_05240	COG1854	S-ribosylhomocysteine lyase activity
GO498_05245	COG4536	flavin adenine dinucleotide binding
GO498_05250	COG4137	Cytochrome C assembly protein
GO498_05255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO498_05260	COG0228	four-way junction DNA binding
GO498_05270	COG0336	Belongs to the RNA methyltransferase TrmD family
GO498_05275	COG0335	large ribosomal subunit rRNA binding
GO498_05280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO498_05285	COG1605	Chorismate mutase
GO498_05285	COG0287	Prephenate dehydrogenase
GO498_05290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO498_05295	COG0077	Prephenate dehydratase
GO498_05295	COG1605	Chorismate mutase
GO498_05300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO498_05305	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO498_05310	COG0564	pseudouridine synthase activity
GO498_05320	COG0542	response to heat
GO498_05350	COG5544	Lipoprotein
GO498_05355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO498_05360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO498_05360	COG1042	CoA-binding domain protein
GO498_05360	COG0045	succinate-CoA ligase (ADP-forming) activity
GO498_05370	COG5160	protein modification by small protein removal
GO498_05375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO498_05380	COG2814	Major facilitator Superfamily
GO498_05385	COG1566	PFAM secretion protein HlyD family protein
GO498_05395	COG2814	Major facilitator Superfamily
GO498_05400	COG1335	isochorismatase
GO498_05405	COG1846	Transcriptional regulator
GO498_05410	COG2814	Major facilitator Superfamily
GO498_05415	COG1629	transport
GO498_05420	COG2113	Glycine betaine
GO498_05425	COG4176	ABC-type proline glycine betaine transport system permease component
GO498_05430	COG4175	Glycine betaine
GO498_05445	COG1780	Probably involved in ribonucleotide reductase function
GO498_05455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO498_05460	COG1278	Cold shock
GO498_05470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO498_05475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO498_05480	COG0321	lipoyl(octanoyl) transferase activity
GO498_05490	COG1686	Belongs to the peptidase S11 family
GO498_05495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO498_05500	COG0772	Belongs to the SEDS family
GO498_05505	COG0768	penicillin binding
GO498_05510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO498_05515	COG0799	negative regulation of ribosome biogenesis
GO498_05525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO498_05530	COG1466	dna polymerase III delta subunit
GO498_05535	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GO498_05540	COG0495	leucyl-tRNA aminoacylation
GO498_05545	COG1126	abc transporter atp-binding protein
GO498_05550	COG0765	amino acid transport
GO498_05555	COG0765	amino acid transport
GO498_05580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO498_05590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GO498_05595	COG4535	Mg2 and Co2 transporter CorC
GO498_05600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO498_05605	COG1702	phosphate starvation-inducible protein PhoH
GO498_05610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO498_05615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO498_05620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GO498_05670	COG1846	Transcriptional regulator
GO498_05670	COG1940	carbohydrate kinase activity
GO498_05675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO498_05680	COG0363	glucosamine-6-phosphate deaminase activity
GO498_05690	COG0582	viral genome integration into host DNA
GO498_05780	COG0305	Participates in initiation and elongation during chromosome replication
GO498_05810	COG3477	response to acidic pH
GO498_05825	COG3772	lysozyme
GO498_06025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO498_06040	COG0735	belongs to the Fur family
GO498_06045	COG0716	FMN binding
GO498_06055	COG0596	Alpha beta hydrolase
GO498_06060	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GO498_06065	COG0033	Phosphoglucomutase
GO498_06070	COG4807	Protein conserved in bacteria
GO498_06075	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
GO498_06090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO498_06100	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GO498_06105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GO498_06110	COG0714	Associated with various cellular activities
GO498_06120	COG2814	Major facilitator Superfamily
GO498_06135	COG2009	succinate dehydrogenase
GO498_06140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO498_06145	COG1053	succinate dehydrogenase
GO498_06155	COG0567	Dehydrogenase, E1 component
GO498_06160	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO498_06165	COG0045	succinate-CoA ligase (ADP-forming) activity
GO498_06170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO498_06175	COG1271	oxidase subunit
GO498_06180	COG1294	oxidase, subunit
GO498_06185	COG4890	Cyd operon protein YbgT
GO498_06190	COG3790	cyd operon protein YbgE
GO498_06195	COG0583	DNA-binding transcription factor activity
GO498_06200	COG0477	Major facilitator Superfamily
GO498_06210	COG0824	Thioesterase
GO498_06215	COG0811	peptide transport
GO498_06220	COG0848	biopolymer transport protein
GO498_06225	COG3064	Membrane
GO498_06230	COG0823	Involved in the tonB-independent uptake of proteins
GO498_06235	COG2885	chlorophyll binding
GO498_06240	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GO498_06265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO498_06270	COG0588	phosphoglycerate mutase activity
GO498_06275	COG1119	ATPase activity
GO498_06280	COG2831	hemolysin activation secretion protein
GO498_06310	COG2005	Transcriptional regulator
GO498_06310	COG3585	molybdate ion transport
GO498_06320	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO498_06325	COG4149	molybdate abc transporter
GO498_06330	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GO498_06335	COG0561	phosphatase activity
GO498_06340	COG2706	6-phosphogluconolactonase activity
GO498_06350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO498_06355	COG0156	8-amino-7-oxononanoate synthase activity
GO498_06360	COG2226	methyltransferase
GO498_06365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GO498_06370	COG0556	nucleotide-excision repair
GO498_06385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO498_06390	COG0315	cyclic pyranopterin monophosphate synthase activity
GO498_06395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO498_06400	COG0314	molybdopterin synthase activity
GO498_06405	COG0670	Belongs to the BI1 family
GO498_06410	COG0842	Transport permease protein
GO498_06415	COG0842	Transport permease protein
GO498_06420	COG1131	(ABC) transporter
GO498_06430	COG1309	transcriptional regulator
GO498_06435	COG0513	Belongs to the DEAD box helicase family
GO498_06440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO498_06450	COG2897	thiosulfate sulfurtransferase activity
GO498_06460	COG3069	C4-dicarboxylate transmembrane transporter activity
GO498_06475	COG2079	MmgE PrpD family protein
GO498_06480	COG0583	DNA-binding transcription factor activity
GO498_06515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO498_06525	COG0477	Major facilitator Superfamily
GO498_06530	COG0302	gtp cyclohydrolase
GO498_06535	COG2311	Membrane
GO498_06540	COG2949	membrane
GO498_06545	COG0281	malic enzyme
GO498_06550	COG0295	cytidine deaminase activity
GO498_06555	COG1346	cytolysis
GO498_06560	COG1380	Effector of murein hydrolase LrgA
GO498_06565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO498_06565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO498_06570	COG0489	protein tyrosine kinase activity
GO498_06575	COG0572	uridine kinase
GO498_06580	COG0717	Belongs to the dCTP deaminase family
GO498_06585	COG2982	Protein involved in outer membrane biogenesis
GO498_06590	COG3069	C4-dicarboxylate transmembrane transporter activity
GO498_06595	COG1253	flavin adenine dinucleotide binding
GO498_06600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO498_06605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO498_06610	COG1454	alcohol dehydrogenase
GO498_06615	COG0140	phosphoribosyl-ATP diphosphatase activity
GO498_06615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO498_06620	COG0107	imidazoleglycerol-phosphate synthase activity
GO498_06625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO498_06630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO498_06635	COG0131	Imidazoleglycerol-phosphate dehydratase
GO498_06635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO498_06645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO498_06650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO498_06655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO498_06660	COG0625	glutathione transferase activity
GO498_06665	COG1686	Belongs to the peptidase S11 family
GO498_06670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GO498_06675	COG1760	l-serine dehydratase
GO498_06680	COG0814	amino acid
GO498_06685	COG0671	phosphoesterase, PA-phosphatase related
GO498_06690	COG0432	Pfam Uncharacterised protein family UPF0047
GO498_06695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO498_06710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO498_06715	COG4160	amino acid transport
GO498_06720	COG4215	(ABC) transporter
GO498_06725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO498_06730	COG1126	abc transporter atp-binding protein
GO498_06735	COG0702	epimerase
GO498_06740	COG2431	L-lysine efflux transmembrane transporter activity
GO498_06745	COG3593	DNA synthesis involved in DNA repair
GO498_06750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO498_06755	COG1136	(ABC) transporter
GO498_06755	COG0577	efflux transmembrane transporter activity
GO498_06760	COG1278	Cold shock
GO498_06765	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO498_06770	COG0542	response to heat
GO498_06775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GO498_06780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO498_06785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO498_06795	COG0492	ferredoxin-NADP+ reductase activity
GO498_06800	COG1522	sequence-specific DNA binding
GO498_06805	COG3107	peptidoglycan biosynthetic process
GO498_06805	COG1674	ftsk spoiiie
GO498_06810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO498_06815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO498_06820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO498_06830	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GO498_06840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO498_06845	COG1882	Formate acetyltransferase
GO498_06850	COG2116	formate transmembrane transporter activity
GO498_06855	COG1944	ATP diphosphatase activity
GO498_06860	COG0252	asparaginase activity
GO498_06865	COG3210	domain, Protein
GO498_06875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO498_06880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO498_06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO498_06890	COG0539	negative regulation of cytoplasmic translation
GO498_06895	COG0776	regulation of translation
GO498_06900	COG0658	competence protein
GO498_06900	COG2333	competence protein COMEC
GO498_06905	COG1132	(ABC) transporter
GO498_06910	COG1663	tetraacyldisaccharide 4'-kinase activity
GO498_06920	COG2835	tetraacyldisaccharide 4'-kinase activity
GO498_06925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GO498_06930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GO498_06935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO498_06940	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GO498_06945	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GO498_06950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GO498_06960	COG3700	Belongs to the class B bacterial acid phosphatase family
GO498_06965	COG2989	Protein conserved in bacteria
GO498_06970	COG3108	Peptidase M15
GO498_06975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO498_06980	COG3157	Type VI secretion system effector, Hcp
GO498_07070	COG3501	Rhs element vgr protein
GO498_07170	COG1448	Aminotransferase
GO498_07175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GO498_07180	COG0017	Asparaginyl-tRNA synthetase
GO498_07190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GO498_07195	COG0308	aminopeptidase N
GO498_07205	COG0167	dihydroorotate dehydrogenase activity
GO498_07215	COG0633	Ferredoxin
GO498_07215	COG3217	Mosc domain protein beta barrel domain protein
GO498_07220	COG0116	Belongs to the methyltransferase superfamily
GO498_07220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO498_07225	COG0488	(ABC) transporter
GO498_07230	COG2995	paraquat-inducible protein a
GO498_07235	COG3008	intermembrane lipid transfer
GO498_07235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO498_07240	COG3009	Protein conserved in bacteria
GO498_07250	COG3130	regulation of translation
GO498_07255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO498_07260	COG1067	ATP-dependent peptidase activity
GO498_07265	COG3120	sequence-specific DNA binding
GO498_07270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GO498_07270	COG2885	chlorophyll binding
GO498_07280	COG3070	regulator of competence-specific genes
GO498_07285	COG1289	transmembrane transporter activity
GO498_07290	COG0210	DNA helicase
GO498_07295	COG1803	Methylglyoxal synthase
GO498_07300	COG1832	CoA-binding protein
GO498_07305	COG3785	DNA binding
GO498_07310	COG1254	Belongs to the acylphosphatase family
GO498_07315	COG2920	part of a sulfur-relay system
GO498_07335	COG3615	Tellurite resistance protein tehB
GO498_07350	COG0583	DNA-binding transcription factor activity
GO498_07355	COG0656	L-ascorbic acid biosynthetic process
GO498_07365	COG3708	Transcriptional regulator
GO498_07365	COG2207	Transcriptional regulator
GO498_07380	COG1278	Cold shock
GO498_07385	COG1560	Kdo2-lipid A biosynthetic process
GO498_07400	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GO498_07415	COG1280	lysine exporter protein (LysE YggA)
GO498_07505	COG3083	sulfuric ester hydrolase activity
GO498_07510	COG3082	Protein of unknown function (DUF1414)
GO498_07515	COG3081	Nucleoid-associated protein
GO498_07520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO498_07525	COG1061	Type III restriction enzyme res subunit
GO498_07530	COG1187	pseudouridine synthase activity
GO498_07535	COG2814	Major facilitator Superfamily
GO498_07545	COG0791	NLP P60 protein
GO498_07550	COG0671	phosphoesterase, PA-phosphatase related
GO498_07565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO498_07575	COG0494	nUDIX hydrolase
GO498_07580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GO498_07585	COG2855	membrane
GO498_07590	COG0583	DNA-binding transcription factor activity
GO498_07595	COG0833	amino acid
GO498_07600	COG4771	TonB-dependent receptor
GO498_07610	COG0531	amino acid
GO498_07620	COG3961	Belongs to the TPP enzyme family
GO498_07625	COG0583	DNA-binding transcription factor activity
GO498_07630	COG0277	FAD linked oxidase domain protein
GO498_07640	COG2925	Exonuclease
GO498_07645	COG2211	Major facilitator Superfamily
GO498_07650	COG2926	Belongs to the UPF0265 family
GO498_07655	COG1530	ribonuclease E activity
GO498_07660	COG0564	pseudouridine synthase activity
GO498_07670	COG0424	maF-like protein
GO498_07675	COG1399	metal-binding, possibly nucleic acid-binding protein
GO498_07680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GO498_07685	COG0416	fatty acid biosynthetic process
GO498_07690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO498_07700	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_07705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO498_07710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO498_07715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO498_07720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO498_07725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO498_07730	COG0470	DNA polymerase III
GO498_07735	COG0084	hydrolase, TatD family'
GO498_07740	COG0537	adenosine 5'-monophosphoramidase activity
GO498_07745	COG5633	Lipoprotein
GO498_07750	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
GO498_07755	COG0510	thiamine kinase activity
GO498_07760	COG1472	Belongs to the glycosyl hydrolase 3 family
GO498_07770	COG1252	NADH dehydrogenase
GO498_07775	COG3134	Outer membrane lipoprotein
GO498_07780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO498_07785	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO498_07795	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO498_07800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO498_07815	COG2850	peptidyl-arginine hydroxylation
GO498_07820	COG2205	protein histidine kinase activity
GO498_07825	COG0745	RESPONSE REGULATOR receiver
GO498_07830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO498_07835	COG2915	High frequency lysogenization protein hflD homolog
GO498_07840	COG0482	sulfurtransferase activity
GO498_07850	COG1187	pseudouridine synthase activity
GO498_07855	COG0538	isocitrate dehydrogenase activity
GO498_07895	COG0538	isocitrate dehydrogenase activity
GO498_07905	COG1078	dGTPase activity
GO498_07910	COG0538	isocitrate dehydrogenase activity
GO498_07925	COG1278	Cold shock
GO498_07930	COG0071	Belongs to the small heat shock protein (HSP20) family
GO498_07940	COG1733	regulation of RNA biosynthetic process
GO498_07945	COG0702	epimerase
GO498_07955	COG0572	uridine kinase
GO498_07970	COG1475	DNA binding
GO498_07975	COG3969	phosphoadenosine phosphosulfate
GO498_07980	COG0500	methyltransferase
GO498_07990	COG3272	Protein of unknown function (DUF1722)
GO498_07995	COG2841	Protein conserved in bacteria
GO498_08025	COG0024	Methionine aminopeptidase
GO498_08035	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO498_08040	COG1598	PFAM Uncharacterised protein family UPF0150
GO498_08045	COG1943	Transposase
GO498_08050	COG0675	Transposase, IS605 OrfB family
GO498_08055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO498_08070	COG0589	response to stress
GO498_08075	COG1528	Iron-storage protein
GO498_08080	COG2372	response to copper ion
GO498_08085	COG1276	copper resistance
GO498_08100	COG3008	intermembrane lipid transfer
GO498_08105	COG2995	paraquat-inducible protein a
GO498_08110	COG1956	GAF domain-containing protein
GO498_08115	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GO498_08130	COG0501	Belongs to the peptidase M48B family
GO498_08140	COG1988	membrane-bound metal-dependent
GO498_08145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO498_08160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO498_08165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO498_08170	COG1121	(ABC) transporter
GO498_08175	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO498_08195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO498_08205	COG3539	Fimbrial protein
GO498_08210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO498_08215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO498_08220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO498_08225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO498_08235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO498_08240	COG0072	phenylalanine-tRNA ligase activity
GO498_08240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO498_08245	COG0776	regulation of translation
GO498_08250	COG4139	cobalamin transport
GO498_08255	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GO498_08260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO498_08265	COG0463	Glycosyl transferase, family 2
GO498_08270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO498_08270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO498_08275	COG0726	polysaccharide deacetylase
GO498_08280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO498_08285	COG2076	Multidrug Resistance protein
GO498_08290	COG2076	Multidrug Resistance protein
GO498_08295	COG0791	NLP P60 protein
GO498_08300	COG0095	Lipoate-protein ligase
GO498_08305	COG2207	Transcriptional regulator
GO498_08310	COG0579	oxidoreductase
GO498_08315	COG2186	Transcriptional regulator
GO498_08330	COG0586	Pfam SNARE associated Golgi protein
GO498_08390	COG0012	GTP binding
GO498_08395	COG0193	aminoacyl-tRNA hydrolase activity
GO498_08405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO498_08410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO498_08415	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GO498_08420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO498_08425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO498_08435	COG2912	Transglutaminase-like superfamily
GO498_08440	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GO498_08445	COG1242	4 iron, 4 sulfur cluster binding
GO498_08455	COG0659	secondary active sulfate transmembrane transporter activity
GO498_08465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO498_08480	COG3381	protein complex oligomerization
GO498_08490	COG0477	Major facilitator Superfamily
GO498_08495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO498_08500	COG0728	peptidoglycan biosynthetic process
GO498_08510	COG0018	arginyl-trna synthetase
GO498_08515	COG3102	Protein conserved in bacteria
GO498_08520	COG3142	Participates in the control of copper homeostasis
GO498_08530	COG0488	(ABC) transporter
GO498_08535	COG0500	methyltransferase
GO498_08540	COG2226	methyltransferase
GO498_08545	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GO498_08550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO498_08555	COG0494	nUDIX hydrolase
GO498_08560	COG0217	transcriptional regulatory protein
GO498_08565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GO498_08570	COG0632	four-way junction helicase activity
GO498_08575	COG2255	four-way junction helicase activity
GO498_08585	COG3501	Rhs element vgr protein
GO498_08595	COG3209	COG3209 Rhs family protein
GO498_08620	COG3209	COG3209 Rhs family protein
GO498_08645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO498_08650	COG1121	(ABC) transporter
GO498_08655	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GO498_08660	COG0739	heme binding
GO498_08665	COG1560	Kdo2-lipid A biosynthetic process
GO498_08670	COG0469	pyruvate kinase activity
GO498_08675	COG1737	Transcriptional regulator
GO498_08680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO498_08685	COG2076	Multidrug Resistance protein
GO498_08690	COG2076	Multidrug Resistance protein
GO498_08695	COG0702	epimerase
GO498_08700	COG0251	oxidation-reduction process
GO498_08705	COG1199	ATP-dependent helicase activity
GO498_08715	COG3065	identical protein binding
GO498_08720	COG0318	PFAM AMP-dependent synthetase and ligase
GO498_08725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GO498_08730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GO498_08735	COG2894	cell division
GO498_08740	COG0850	regulation of cytokinetic process
GO498_08745	COG3100	YcgL domain-containing protein
GO498_08750	COG2951	lytic endotransglycosylase activity
GO498_08755	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO498_08760	COG2983	Belongs to the UPF0260 family
GO498_08765	COG0390	transport system, permease component
GO498_08770	COG4619	ABC transporter
GO498_08780	COG3708	Transcriptional regulator
GO498_08780	COG2207	Transcriptional regulator
GO498_08795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO498_08800	COG2911	Protein conserved in bacteria
GO498_08810	COG3784	Protein of unknown function (DUF1318)
GO498_08840	COG1643	Atp-dependent helicase
GO498_08855	COG3188	usher protein
GO498_08860	COG3121	Chaperone
GO498_08870	COG0531	amino acid
GO498_08880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GO498_08885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO498_08890	COG0589	response to stress
GO498_08895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO498_08900	COG0243	molybdopterin cofactor binding
GO498_08905	COG0437	4 iron, 4 sulfur cluster binding
GO498_08930	COG1695	Transcriptional regulator
GO498_08940	COG0450	alkyl hydroperoxide reductase
GO498_08945	COG3634	alkyl hydroperoxide reductase activity
GO498_09045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO498_09050	COG4974	Belongs to the 'phage' integrase family
GO498_09060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO498_09065	COG1129	ABC transporter
GO498_09065	COG0842	Transport permease protein
GO498_09070	COG0842	Transport permease protein
GO498_09075	COG0745	RESPONSE REGULATOR receiver
GO498_09080	COG2205	protein histidine kinase activity
GO498_09085	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GO498_09095	COG3302	dmso reductase anchor subunit
GO498_09100	COG0437	4 iron, 4 sulfur cluster binding
GO498_09105	COG0243	molybdopterin cofactor binding
GO498_09110	COG1349	DNA-binding transcription factor activity
GO498_09130	COG2376	Dihydroxyacetone kinase
GO498_09140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO498_09150	COG0251	oxidation-reduction process
GO498_09170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO498_09175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO498_09175	COG2169	Transcriptional regulator
GO498_09190	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO498_09210	COG1464	Belongs to the NlpA lipoprotein family
GO498_09230	COG2814	Major facilitator Superfamily
GO498_09240	COG0583	DNA-binding transcription factor activity
GO498_09250	COG1309	transcriptional regulator
GO498_09260	COG0488	(ABC) transporter
GO498_09265	COG1671	Belongs to the UPF0178 family
GO498_09270	COG0402	S-adenosylhomocysteine deaminase activity
GO498_09275	COG0583	DNA-binding transcription factor activity
GO498_09280	COG2814	Major facilitator Superfamily
GO498_09290	COG0477	Major facilitator Superfamily
GO498_09295	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GO498_09310	COG1289	transmembrane transporter activity
GO498_09315	COG1538	Outer membrane efflux protein
GO498_09325	COG0443	Heat shock 70 kDa protein
GO498_09345	COG1070	Carbohydrate kinase
GO498_09350	COG2115	Belongs to the xylose isomerase family
GO498_09355	COG1757	Na H antiporter
GO498_09365	COG1609	Transcriptional regulator
GO498_09365	COG2207	Transcriptional regulator
GO498_09370	COG4628	conserved protein (DUF2132)
GO498_09440	COG4221	oxidoreductase activity
GO498_09455	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GO498_09460	COG1940	carbohydrate kinase activity
GO498_09465	COG0583	DNA-binding transcription factor activity
GO498_09470	COG2814	Major facilitator Superfamily
GO498_09480	COG0114	fumarate hydratase activity
GO498_09485	COG5339	Protein conserved in bacteria
GO498_09495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO498_09500	COG0385	Bile acid
GO498_09505	COG0673	inositol 2-dehydrogenase activity
GO498_09515	COG4657	Part of a membrane complex involved in electron transport
GO498_09525	COG4656	Part of a membrane complex involved in electron transport
GO498_09535	COG4659	FMN binding
GO498_09545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO498_09550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GO498_09555	COG0023	Translation Initiation Factor
GO498_09560	COG0284	orotidine-5'-phosphate decarboxylase activity
GO498_09565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GO498_09570	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GO498_09575	COG0671	phosphoesterase, PA-phosphatase related
GO498_09580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO498_09585	COG1464	Belongs to the NlpA lipoprotein family
GO498_09595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO498_09605	COG0583	DNA-binding transcription factor activity
GO498_09620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO498_09630	COG0616	signal peptide processing
GO498_09635	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_09650	COG1187	pseudouridine synthase activity
GO498_09655	COG0009	L-threonylcarbamoyladenylate synthase
GO498_09665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO498_09670	COG0512	Glutamine amidotransferase of anthranilate synthase
GO498_09675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO498_09685	COG0133	tryptophan synthase activity
GO498_09690	COG0159	tryptophan synthase activity
GO498_09700	COG3047	cAMP biosynthetic process
GO498_09715	COG2917	probably involved in intracellular septation
GO498_09720	COG1607	acyl-coa hydrolase
GO498_09735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO498_09750	COG0346	lactoylglutathione lyase activity
GO498_09770	COG0598	Magnesium transport protein CorA
GO498_09785	COG4166	transmembrane transport
GO498_09790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GO498_09805	COG3768	UPF0283 membrane protein
GO498_09810	COG3106	COG3106 Predicted ATPase
GO498_09820	COG1983	PspC domain protein
GO498_09830	COG1842	Phage shock protein A
GO498_09835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO498_09840	COG4166	transmembrane transport
GO498_09845	COG4168	peptide transport system, permease
GO498_09850	COG4171	peptide transport system, permease
GO498_09855	COG4172	Belongs to the ABC transporter superfamily
GO498_09865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO498_09880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO498_09885	COG0259	pyridoxamine-phosphate oxidase activity
GO498_09890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO498_09895	COG3133	Outer membrane lipoprotein
GO498_09905	COG3313	Fe-S protein
GO498_09910	COG0346	lactoylglutathione lyase activity
GO498_09915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO498_09920	COG0675	Transposase, IS605 OrfB family
GO498_09925	COG1943	Transposase
GO498_09930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO498_10165	COG0305	Participates in initiation and elongation during chromosome replication
GO498_10245	COG3723	Recombinational DNA repair protein, rece pathway
GO498_10255	COG0629	single-stranded DNA binding
GO498_10305	COG0582	viral genome integration into host DNA
GO498_10310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO498_10325	COG0730	response to heat
GO498_10330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO498_10340	COG1609	Transcriptional regulator
GO498_10345	COG0583	DNA-binding transcription factor activity
GO498_10350	COG2814	Major facilitator Superfamily
GO498_10355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO498_10360	COG0307	riboflavin synthase, alpha
GO498_10365	COG0534	Mate efflux family protein
GO498_10385	COG0531	amino acid
GO498_10390	COG0076	glutamate decarboxylase activity
GO498_10405	COG1388	LysM domain
GO498_10405	COG1376	ErfK ybiS ycfS ynhG family protein
GO498_10410	COG2166	iron-sulfur cluster assembly
GO498_10415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO498_10420	COG0719	Fe-S assembly protein
GO498_10425	COG0396	ATPase activity
GO498_10430	COG0719	Fe-S assembly protein
GO498_10435	COG0316	Belongs to the HesB IscA family
GO498_10445	COG2050	protein possibly involved in aromatic compounds catabolism
GO498_10450	COG0277	FAD linked oxidase domain protein
GO498_10450	COG0247	lactate metabolic process
GO498_10455	COG0628	permease
GO498_10460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO498_10460	COG0574	Belongs to the PEP-utilizing enzyme family
GO498_10465	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GO498_10470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO498_10485	COG4771	TonB-dependent receptor
GO498_10490	COG3720	iron ion transport
GO498_10495	COG4558	Periplasmic binding protein
GO498_10500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO498_10505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GO498_10515	COG1280	lysine exporter protein (LysE YggA)
GO498_10520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO498_10525	COG1271	oxidase subunit
GO498_10530	COG1294	oxidase, subunit
GO498_10545	COG3152	Membrane
GO498_10550	COG1702	phosphate starvation-inducible protein PhoH
GO498_10560	COG2356	endonuclease I
GO498_10570	COG3610	response to peptide
GO498_10575	COG2966	Psort location CytoplasmicMembrane, score
GO498_10600	COG0589	response to stress
GO498_10610	COG0589	response to stress
GO498_10630	COG0113	porphobilinogen synthase activity
GO498_10640	COG0402	S-adenosylhomocysteine deaminase activity
GO498_10645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO498_10650	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GO498_10655	COG1012	belongs to the aldehyde dehydrogenase family
GO498_10660	COG1309	transcriptional regulator
GO498_10665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO498_10670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO498_10685	COG3188	usher protein
GO498_10695	COG3539	Fimbrial protein
GO498_10705	COG1396	sequence-specific DNA binding
GO498_10715	COG0444	Belongs to the ABC transporter superfamily
GO498_10720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO498_10725	COG0601	transmembrane transport
GO498_10745	COG2146	nitrite reductase [NAD(P)H] activity
GO498_10750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO498_10755	COG4166	transmembrane transport
GO498_10760	COG0601	transmembrane transport
GO498_10775	COG4608	Belongs to the ABC transporter superfamily
GO498_10780	COG2095	MarC family integral membrane protein
GO498_10785	COG1012	belongs to the aldehyde dehydrogenase family
GO498_10785	COG1454	alcohol dehydrogenase
GO498_10790	COG1435	thymidine kinase activity
GO498_10805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO498_10810	COG0745	RESPONSE REGULATOR receiver
GO498_10815	COG3012	SEC-C Motif Domain Protein
GO498_10820	COG0788	formyltetrahydrofolate deformylase activity
GO498_10830	COG0583	DNA-binding transcription factor activity
GO498_10835	COG0708	Exodeoxyribonuclease III
GO498_10840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO498_10845	COG0709	Synthesizes selenophosphate from selenide and ATP
GO498_10850	COG0778	Nitroreductase
GO498_10855	COG0616	signal peptide processing
GO498_10860	COG0252	asparaginase activity
GO498_10865	COG1335	isochorismatase
GO498_10870	COG3139	Protein of unknown function (DUF1315)
GO498_10875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO498_10890	COG3713	MltA-interacting MipA family protein
GO498_10895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GO498_10900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO498_10905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO498_10910	COG2186	Transcriptional regulator
GO498_10915	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO498_10920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO498_10930	COG2076	Multidrug Resistance protein
GO498_10950	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GO498_10955	COG3683	transport system, periplasmic component
GO498_10985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO498_10990	COG0322	excinuclease ABC activity
GO498_10995	COG2197	response regulator
GO498_11000	COG0778	Nitroreductase
GO498_11005	COG1494	fructose-1,6-bisphosphatase
GO498_11010	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GO498_11025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_11070	COG3842	ATPase activity
GO498_11080	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO498_11085	COG2390	Transcriptional regulator
GO498_11090	COG1324	tolerance protein
GO498_11105	COG3541	Predicted nucleotidyltransferase
GO498_11150	COG0582	viral genome integration into host DNA
GO498_11155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO498_11155	COG0519	Catalyzes the synthesis of GMP from XMP
GO498_11160	COG0517	IMP dehydrogenase activity
GO498_11160	COG0516	GMP reductase activity
GO498_11165	COG1570	exodeoxyribonuclease VII activity
GO498_11175	COG1770	oligopeptidase
GO498_11190	COG0280	phosphate acetyltransferase
GO498_11190	COG0281	malic enzyme
GO498_11195	COG2197	response regulator
GO498_11205	COG1393	Belongs to the ArsC family
GO498_11210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO498_11215	COG1876	peptidase activity
GO498_11225	COG0675	Transposase, IS605 OrfB family
GO498_11230	COG2832	Protein of unknown function (DUF454)
GO498_11240	COG1444	tRNA N-acetyltransferase activity
GO498_11245	COG2707	UPF0756 membrane protein
GO498_11250	COG2321	neutral zinc metallopeptidase
GO498_11255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO498_11260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GO498_11265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO498_11270	COG2716	regulation of RNA biosynthetic process
GO498_11275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO498_11280	COG0628	permease
GO498_11285	COG4783	chaperone-mediated protein folding
GO498_11290	COG1393	Belongs to the ArsC family
GO498_11295	COG2211	Major facilitator Superfamily
GO498_11300	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO498_11305	COG0668	transmembrane transport
GO498_11310	COG2233	PERMEase
GO498_11315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO498_11320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO498_11325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO498_11330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO498_11335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GO498_11340	COG0248	Ppx GppA phosphatase
GO498_11345	COG2239	Acts as a magnesium transporter
GO498_11370	COG3104	oligopeptide transport
GO498_11375	COG0675	Transposase, IS605 OrfB family
GO498_11385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO498_11390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO498_11395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO498_11400	COG2205	protein histidine kinase activity
GO498_11405	COG0745	RESPONSE REGULATOR receiver
GO498_11415	COG1597	lipid kinase activity
GO498_11420	COG1830	Aldolase
GO498_11435	COG1113	amino acid transport
GO498_11450	COG0561	phosphatase activity
GO498_11455	COG1114	Component of the transport system for branched-chain amino acids
GO498_11460	COG3023	N-Acetylmuramoyl-L-alanine amidase
GO498_11465	COG1115	amino acid carrier protein
GO498_11480	COG3140	Belongs to the UPF0181 family
GO498_11490	COG0494	nUDIX hydrolase
GO498_11495	COG1760	l-serine dehydratase
GO498_11500	COG1971	Probably functions as a manganese efflux pump
GO498_11505	COG2226	methyltransferase
GO498_11515	COG0589	response to stress
GO498_11525	COG0589	response to stress
GO498_11530	COG1113	amino acid transport
GO498_11540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO498_11545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO498_11545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO498_11545	COG0506	proline dehydrogenase activity
GO498_11555	COG1191	sigma factor activity
GO498_11605	COG1677	Flagellar hook-basal body complex protein FliE
GO498_11610	COG1766	The M ring may be actively involved in energy transduction
GO498_11615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO498_11625	COG1157	protein secretion by the type III secretion system
GO498_11630	COG2882	bacterial-type flagellum organization
GO498_11640	COG1580	Controls the rotational direction of flagella during chemotaxis
GO498_11655	COG3190	flagellar
GO498_11660	COG1338	Plays a role in the flagellum-specific transport system
GO498_11665	COG1987	bacterial-type flagellum assembly
GO498_11680	COG1256	bacterial-type flagellum assembly
GO498_11690	COG1706	bacterial-type flagellum-dependent cell motility
GO498_11695	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GO498_11700	COG4786	Flagellar basal body rod
GO498_11710	COG1749	Flagellar hook protein flgE
GO498_11715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO498_11720	COG1558	bacterial-type flagellum-dependent cell motility
GO498_11725	COG1815	bacterial-type flagellum-dependent cell motility
GO498_11745	COG3210	domain, Protein
GO498_11760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO498_11775	COG0745	RESPONSE REGULATOR receiver
GO498_11780	COG2201	protein-glutamate methylesterase activity
GO498_11790	COG0840	transmembrane signaling receptor activity
GO498_11795	COG0840	transmembrane signaling receptor activity
GO498_11800	COG0835	chemotaxis
GO498_11805	COG2198	Histidine kinase
GO498_11805	COG0643	Histidine kinase
GO498_11810	COG1360	Flagellar Motor Protein
GO498_11830	COG1285	pathogenesis
GO498_11840	COG1278	Cold shock
GO498_11870	COG0418	dihydroorotase activity
GO498_11910	COG1560	Kdo2-lipid A biosynthetic process
GO498_11915	COG2814	Major facilitator Superfamily
GO498_11920	COG3104	oligopeptide transport
GO498_11930	COG1607	acyl-coa hydrolase
GO498_11945	COG1902	pentaerythritol trinitrate reductase activity
GO498_11970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GO498_11975	COG1396	sequence-specific DNA binding
GO498_11985	COG3247	response to pH
GO498_11990	COG0668	transmembrane transport
GO498_11995	COG0243	molybdopterin cofactor binding
GO498_12000	COG0437	4 iron, 4 sulfur cluster binding
GO498_12005	COG3302	dmso reductase anchor subunit
GO498_12300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO498_12500	COG0582	viral genome integration into host DNA
GO498_12510	COG2198	Histidine kinase
GO498_12510	COG0642	Histidine kinase
GO498_12515	COG2197	response regulator
GO498_12520	COG2205	protein histidine kinase activity
GO498_12520	COG0784	Response regulator, receiver
GO498_12530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO498_12535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO498_12540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO498_12545	COG0633	Ferredoxin
GO498_12555	COG0814	amino acid
GO498_12575	COG1441	menaquinone biosynthetic process
GO498_12580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO498_12585	COG0596	Alpha beta hydrolase
GO498_12590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO498_12595	COG1169	isochorismate synthase
GO498_12610	COG1007	ATP synthesis coupled electron transport
GO498_12615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO498_12620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO498_12625	COG0713	ATP synthesis coupled electron transport
GO498_12630	COG0839	Belongs to the complex I subunit 6 family
GO498_12635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO498_12640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GO498_12645	COG1034	ATP synthesis coupled electron transport
GO498_12650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GO498_12655	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GO498_12660	COG0649	NAD binding
GO498_12660	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO498_12665	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO498_12670	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO498_12680	COG0583	DNA-binding transcription factor activity
GO498_12685	COG0436	Aminotransferase
GO498_12690	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GO498_12695	COG0471	metal ion transport
GO498_12695	COG0490	domain, Protein
GO498_12700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO498_12705	COG3013	Belongs to the UPF0304 family
GO498_12710	COG3092	negative regulation of chromosome organization
GO498_12715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO498_12720	COG0857	belongs to the CobB CobQ family
GO498_12720	COG0280	phosphate acetyltransferase
GO498_12750	COG3037	sugar-specific permease SgaT UlaA
GO498_12760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO498_12770	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GO498_12775	COG0625	glutathione transferase activity
GO498_12780	COG1090	epimerase
GO498_12785	COG0163	prenyltransferase activity
GO498_12790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO498_12795	COG1286	toxin biosynthetic process
GO498_12800	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GO498_12805	COG0285	dihydrofolate synthase activity
GO498_12810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO498_12815	COG0586	Pfam SNARE associated Golgi protein
GO498_12825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO498_12830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO498_12835	COG2207	Transcriptional regulator
GO498_12840	COG0697	spore germination
GO498_12845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO498_12850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GO498_12850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO498_12870	COG3101	peptidyl-lysine hydroxylation
GO498_12875	COG0730	response to heat
GO498_12880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO498_12885	COG2890	protein-(glutamine-N5) methyltransferase activity
GO498_12890	COG0783	Belongs to the Dps family
GO498_12895	COG2840	Smr protein MutS2
GO498_12900	COG2062	phosphohistidine phosphatase, SixA
GO498_12905	COG1024	Enoyl-CoA hydratase
GO498_12905	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO498_12910	COG0183	Belongs to the thiolase family
GO498_12915	COG3691	Protein conserved in bacteria
GO498_12920	COG2067	long-chain fatty acid transport protein
GO498_12950	COG0437	4 iron, 4 sulfur cluster binding
GO498_12960	COG1396	sequence-specific DNA binding
GO498_13005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO498_13020	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_13030	COG3530	Putative quorum-sensing-regulated virulence factor
GO498_13035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO498_13040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO498_13050	COG3115	cell septum assembly
GO498_13060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO498_13065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO498_13075	COG2190	(PTS) system
GO498_13080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO498_13085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GO498_13090	COG4208	sulfate ABC transporter
GO498_13095	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GO498_13105	COG2837	iron assimilation
GO498_13115	COG0456	acetyltransferase
GO498_13120	COG0408	coproporphyrinogen oxidase activity
GO498_13130	COG1160	GTP binding
GO498_13135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO498_13140	COG2976	Protein conserved in bacteria
GO498_13145	COG0124	histidyl-tRNA synthetase
GO498_13150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO498_13165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GO498_13170	COG0105	UTP biosynthetic process
GO498_13175	COG4953	penicillin-binding protein 1C
GO498_13180	COG2373	Large extracellular alpha-helical protein
GO498_13190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO498_13195	COG2975	iron-sulfur cluster assembly
GO498_13200	COG0633	Ferredoxin
GO498_13205	COG0443	Heat shock 70 kDa protein
GO498_13210	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO498_13215	COG0316	Belongs to the HesB IscA family
GO498_13220	COG0822	iron-sulfur transferase activity
GO498_13225	COG1104	cysteine desulfurase activity
GO498_13230	COG1959	2 iron, 2 sulfur cluster binding
GO498_13235	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GO498_13240	COG0483	inositol monophosphate 1-phosphatase activity
GO498_13255	COG2814	Major facilitator Superfamily
GO498_13260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO498_13265	COG1017	nitric oxide dioxygenase activity
GO498_13265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO498_13275	COG0347	Belongs to the P(II) protein family
GO498_13280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO498_13280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO498_13285	COG2204	response regulator
GO498_13290	COG3170	Tfp pilus assembly protein FimV
GO498_13295	COG2205	protein histidine kinase activity
GO498_13300	COG0047	phosphoribosylformylglycinamidine synthase activity
GO498_13300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO498_13305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GO498_13310	COG3539	Fimbrial protein
GO498_13315	COG3188	usher protein
GO498_13320	COG3121	Chaperone
GO498_13325	COG3539	Fimbrial protein
GO498_13330	COG3539	Fimbrial protein
GO498_13335	COG0590	tRNA wobble adenosine to inosine editing
GO498_13340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO498_13345	COG0736	holo-[acyl-carrier-protein] synthase activity
GO498_13350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO498_13355	COG1381	Involved in DNA repair and RecF pathway recombination
GO498_13360	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO498_13365	COG0571	ribonuclease III activity
GO498_13370	COG0681	Belongs to the peptidase S26 family
GO498_13375	COG0481	GTPase activity
GO498_13380	COG3086	response to oxidative stress
GO498_13385	COG3026	antisigma factor binding
GO498_13390	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GO498_13395	COG1595	DNA-templated transcription, initiation
GO498_13400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO498_13405	COG0513	Belongs to the DEAD box helicase family
GO498_13410	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GO498_13420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO498_13425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO498_13430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO498_13435	COG0497	DNA recombination
GO498_13445	COG2914	Belongs to the UPF0125 (RnfH) family
GO498_13450	COG2867	negative regulation of translational initiation
GO498_13455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO498_13470	COG0494	nUDIX hydrolase
GO498_13500	COG1479	Protein of unknown function DUF262
GO498_13505	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GO498_13525	COG0697	spore germination
GO498_13530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO498_13565	COG2831	hemolysin activation secretion protein
GO498_13590	COG0579	oxidoreductase
GO498_13605	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO498_13610	COG2814	Major facilitator Superfamily
GO498_13615	COG1620	l-lactate permease
GO498_13620	COG0247	lactate metabolic process
GO498_13625	COG1139	Iron-sulfur cluster binding protein
GO498_13630	COG1556	Lactate utilization protein
GO498_13650	COG3738	Protein conserved in bacteria
GO498_13660	COG2819	hydrolase of the alpha beta superfamily
GO498_13665	COG4771	TonB-dependent receptor
GO498_13675	COG1609	Transcriptional regulator
GO498_13680	COG2017	converts alpha-aldose to the beta-anomer
GO498_13685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO498_13690	COG1085	galactose-1-phosphate uridylyltransferase
GO498_13695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO498_13705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO498_13710	COG0589	response to stress
GO498_13715	COG4574	serine-type endopeptidase inhibitor activity
GO498_13720	COG2841	Protein conserved in bacteria
GO498_13795	COG3188	usher protein
GO498_13800	COG3121	Chaperone
GO498_13805	COG3539	Fimbrial protein
GO498_13845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO498_13855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO498_13860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO498_13870	COG0716	FMN binding
GO498_13885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GO498_13890	COG0354	folic acid binding
GO498_13900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO498_13900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO498_13905	COG0509	glycine decarboxylation via glycine cleavage system
GO498_13910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO498_13915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO498_13920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO498_13925	COG0006	proline dipeptidase activity
GO498_13930	COG3079	Belongs to the UPF0149 family
GO498_13935	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GO498_13945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO498_13955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO498_13965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO498_13970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GO498_13975	COG0583	DNA-binding transcription factor activity
GO498_13995	COG1279	arginine transmembrane transporter activity
GO498_14005	COG3112	Uncharacterised protein family (UPF0231)
GO498_14025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO498_14030	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO498_14035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GO498_14040	COG2186	Transcriptional regulator
GO498_14045	COG3023	N-Acetylmuramoyl-L-alanine amidase
GO498_14050	COG4969	Belongs to the N-Me-Phe pilin family
GO498_14055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO498_14065	COG0237	dephospho-CoA kinase activity
GO498_14070	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GO498_14075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO498_14100	COG0789	Transcriptional regulator
GO498_14105	COG0653	protein targeting
GO498_14120	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GO498_14130	COG0849	cell division
GO498_14135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO498_14145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO498_14150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO498_14155	COG0772	Belongs to the SEDS family
GO498_14165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO498_14170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO498_14175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO498_14180	COG0768	penicillin binding
GO498_14190	COG0275	rRNA processing
GO498_14195	COG2001	Belongs to the MraZ family
GO498_14200	COG1609	Transcriptional regulator
GO498_14205	COG1022	Amp-dependent synthetase and ligase
GO498_14220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO498_14225	COG0473	3-isopropylmalate dehydrogenase activity
GO498_14230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO498_14235	COG0066	3-isopropylmalate dehydratase activity
GO498_14240	COG4533	DNA binding
GO498_14245	COG3066	DNA modification
GO498_14255	COG3657	addiction module killer protein
GO498_14265	COG0010	Belongs to the arginase family
GO498_14270	COG1166	arginine decarboxylase activity
GO498_14275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GO498_14290	COG1192	Involved in chromosome partitioning
GO498_14300	COG1215	transferase activity, transferring glycosyl groups
GO498_14320	COG0640	Transcriptional regulator
GO498_14325	COG3091	SprT-like family
GO498_14330	COG2239	Acts as a magnesium transporter
GO498_14340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO498_14345	COG1151	hydroxylamine reductase activity
GO498_14355	COG1115	amino acid carrier protein
GO498_14370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO498_14375	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GO498_14380	COG2353	YceI-like domain
GO498_14385	COG3038	cytochrome b561
GO498_14400	COG5295	Hep Hag repeat protein
GO498_14410	COG3119	arylsulfatase activity
GO498_14440	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_14450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO498_14455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO498_14455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_14460	COG3716	PTS system mannose fructose sorbose family IID component
GO498_14465	COG3715	PTS system
GO498_14470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_14475	COG2222	sugar isomerase
GO498_14485	COG1349	DNA-binding transcription factor activity
GO498_14490	COG0641	radical SAM
GO498_14495	COG3119	arylsulfatase activity
GO498_14505	COG0191	fructose-bisphosphate aldolase activity
GO498_14510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_14515	COG0800	Aldolase
GO498_14530	COG0384	phenazine biosynthesis protein PhzF
GO498_14535	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO498_14540	COG0640	Transcriptional regulator
GO498_14550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GO498_14815	COG0305	Participates in initiation and elongation during chromosome replication
GO498_14895	COG3723	Recombinational DNA repair protein, rece pathway
GO498_14955	COG0582	viral genome integration into host DNA
GO498_14965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO498_14970	COG2501	S4 domain
GO498_14975	COG1105	Belongs to the carbohydrate kinase PfkB family
GO498_14980	COG0215	cysteine-tRNA ligase activity
GO498_14985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO498_14990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO498_14995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO498_15000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO498_15010	COG0668	transmembrane transport
GO498_15015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GO498_15020	COG4181	ATPase activity
GO498_15025	COG2755	lipolytic protein G-D-S-L family
GO498_15030	COG0300	oxidoreductase activity
GO498_15035	COG3118	belongs to the thioredoxin family
GO498_15040	COG0330	HflC and HflK could
GO498_15050	COG0789	Transcriptional regulator
GO498_15065	COG3735	TraB family
GO498_15075	COG0737	Belongs to the 5'-nucleotidase family
GO498_15080	COG4651	solute:proton antiporter activity
GO498_15080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO498_15085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_15090	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GO498_15095	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO498_15100	COG0563	adenylate kinase activity
GO498_15105	COG0326	Molecular chaperone. Has ATPase activity
GO498_15110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO498_15115	COG2962	Rard protein
GO498_15135	COG4566	intracellular signal transduction
GO498_15150	COG4589	Belongs to the CDS family
GO498_15160	COG0583	DNA-binding transcription factor activity
GO498_15170	COG0549	Belongs to the carbamate kinase family
GO498_15180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO498_15185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO498_15190	COG1335	isochorismatase
GO498_15205	COG0471	metal ion transport
GO498_15230	COG3539	Fimbrial protein
GO498_15240	COG3121	Chaperone
GO498_15295	COG1396	sequence-specific DNA binding
GO498_15300	COG0613	PHP domain protein
GO498_15305	COG2190	(PTS) system
GO498_15305	COG1263	PTS System
GO498_15305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_15310	COG3711	transcriptional antiterminator
GO498_15315	COG0456	acetyltransferase
GO498_15320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO498_15330	COG1388	LysM domain
GO498_15330	COG4942	peptidase
GO498_15335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GO498_15340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO498_15345	COG0585	pseudouridine synthase activity
GO498_15350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO498_15355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO498_15370	COG2895	sulfate adenylyltransferase (ATP) activity
GO498_15375	COG0175	sulfate reduction
GO498_15380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO498_15380	COG1648	precorrin-2 dehydrogenase activity
GO498_15385	COG0175	sulfate reduction
GO498_15390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO498_15395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO498_15400	COG0720	synthase
GO498_15405	COG0602	queuosine metabolic process
GO498_15460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GO498_15465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO498_15470	COG2011	ABC-type metal ion transport system permease component
GO498_15475	COG1464	Belongs to the NlpA lipoprotein family
GO498_15485	COG1720	tRNA m6t6A37 methyltransferase activity
GO498_15490	COG0442	prolyl-tRNA aminoacylation
GO498_15495	COG3015	lipoprotein NlpE involved in copper resistance
GO498_15500	COG4568	rho-dependent transcription termination
GO498_15505	COG0037	tRNA processing
GO498_15515	COG0825	malonyl-CoA metabolic process
GO498_15525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO498_15530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO498_15535	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO498_15540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO498_15545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO498_15565	COG0575	Belongs to the CDS family
GO498_15570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO498_15575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO498_15580	COG0233	cytoplasmic translational termination
GO498_15585	COG0528	UMP kinase activity
GO498_15590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO498_15595	COG0052	Belongs to the universal ribosomal protein uS2 family
GO498_15600	COG0024	Methionine aminopeptidase
GO498_15605	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GO498_15610	COG2171	N-acyltransferase activity
GO498_15620	COG0716	FMN binding
GO498_15630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_15630	COG1263	PTS System
GO498_15640	COG3098	single-species biofilm formation
GO498_15650	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO498_15650	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO498_15655	COG1611	Belongs to the LOG family
GO498_15660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO498_15665	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GO498_15670	COG2363	Small membrane protein
GO498_15675	COG0583	DNA-binding transcription factor activity
GO498_15680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO498_15685	COG2166	iron-sulfur cluster assembly
GO498_15690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO498_15695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GO498_15715	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO498_15720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GO498_15720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO498_15725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO498_15730	COG1074	ATP-dependent DNA helicase activity
GO498_15735	COG1025	Belongs to the peptidase M16 family
GO498_15740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GO498_15780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO498_15790	COG0494	nUDIX hydrolase
GO498_15795	COG4143	(ABC) transporter
GO498_15800	COG1178	ABC-type Fe3 transport system permease component
GO498_15805	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GO498_15810	COG3311	Transcriptional regulator
GO498_15820	COG0417	DNA replication proofreading
GO498_15825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO498_15830	COG0564	pseudouridine synthase activity
GO498_15835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GO498_15840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GO498_15845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO498_15850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GO498_15855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO498_15860	COG2967	ApaG domain
GO498_15865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO498_15885	COG2132	Multicopper oxidase
GO498_15890	COG0204	Acyl-transferase
GO498_15895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO498_15900	COG0187	DNA topoisomerase II activity
GO498_15905	COG3150	esterase
GO498_15910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO498_15915	COG0494	nUDIX hydrolase
GO498_15920	COG1538	Outer membrane efflux protein
GO498_15925	COG5463	Belongs to the UPF0441 family
GO498_15930	COG0754	glutathionylspermidine amidase activity
GO498_15935	COG3384	dioxygenase
GO498_15940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO498_15950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO498_15950	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GO498_15955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO498_15960	COG3025	triphosphatase activity
GO498_15965	COG4991	sh3 domain protein
GO498_15970	COG0617	tRNA 3'-terminal CCA addition
GO498_15975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO498_15980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO498_16000	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GO498_16005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO498_16015	COG0358	DNA primase activity
GO498_16020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO498_16035	COG3781	membrane
GO498_16045	COG1294	oxidase, subunit
GO498_16050	COG1271	oxidase subunit
GO498_16055	COG0243	molybdopterin cofactor binding
GO498_16060	COG0583	DNA-binding transcription factor activity
GO498_16065	COG0840	transmembrane signaling receptor activity
GO498_16070	COG0840	transmembrane signaling receptor activity
GO498_16075	COG0560	Phosphoserine phosphatase
GO498_16120	COG1358	cellular component organization or biogenesis
GO498_16175	COG2376	Dihydroxyacetone kinase
GO498_16180	COG1461	Dihydroxyacetone kinase
GO498_16185	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GO498_16185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO498_16185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO498_16195	COG4191	Histidine kinase
GO498_16205	COG2271	Major facilitator Superfamily
GO498_16210	COG0469	pyruvate kinase activity
GO498_16215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO498_16225	COG2851	Citrate transporter
GO498_16230	COG0813	purine-nucleoside phosphorylase activity
GO498_16235	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO498_16240	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO498_16245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO498_16250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO498_16255	COG0084	hydrolase, TatD family'
GO498_16260	COG4667	esterase of the alpha-beta hydrolase superfamily
GO498_16270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO498_16295	COG2813	Specifically methylates the guanine in position
GO498_16310	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO498_16320	COG2382	esterase
GO498_16340	COG0560	Phosphoserine phosphatase
GO498_16345	COG3726	membrane protein affecting hemolysin expression
GO498_16350	COG1328	CTP reductase activity
GO498_16355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO498_16375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO498_16390	COG1216	Glycosyl transferase, family 2
GO498_16395	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO498_16405	COG3260	NADH ubiquinone oxidoreductase 20
GO498_16410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO498_16415	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GO498_16415	COG3261	NADH dehydrogenase
GO498_16420	COG0651	ATP synthesis coupled electron transport
GO498_16425	COG4237	Hydrogenase 4 membrane
GO498_16430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO498_16435	COG0650	Formate hydrogenlyase subunit 4
GO498_16440	COG0651	ATP synthesis coupled electron transport
GO498_16445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO498_16450	COG0698	ribose 5-phosphate isomerase
GO498_16455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO498_16460	COG1509	lysine 2,3-aminomutase activity
GO498_16470	COG3188	usher protein
GO498_16505	COG0702	epimerase
GO498_16515	COG0675	Transposase, IS605 OrfB family
GO498_16520	COG1943	Transposase
GO498_16525	COG0459	protein refolding
GO498_16530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GO498_16545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GO498_16550	COG1309	transcriptional regulator
GO498_16785	COG4771	TonB-dependent receptor
GO498_16790	COG2814	Major facilitator Superfamily
GO498_16800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO498_16800	COG3433	isochorismatase activity
GO498_16800	COG2226	methyltransferase
GO498_16815	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GO498_16820	COG1132	(ABC) transporter
GO498_16890	COG3059	membrane
GO498_16915	COG1982	Orn Lys Arg decarboxylase major
GO498_16950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO498_16995	COG0305	Participates in initiation and elongation during chromosome replication
GO498_17020	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO498_17025	COG1704	LemA family
GO498_17040	COG2255	four-way junction helicase activity
GO498_17045	COG2271	Major facilitator Superfamily
GO498_17050	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GO498_17055	COG0644	oxidoreductase
GO498_17075	COG1960	acyl-CoA dehydrogenase activity
GO498_17080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GO498_17085	COG0318	PFAM AMP-dependent synthetase and ligase
GO498_17090	COG1024	Enoyl-CoA hydratase
GO498_17110	COG3397	chitin binding
GO498_17115	COG2137	regulation of response to DNA damage stimulus
GO498_17135	COG2992	FlgJ-related protein
GO498_17160	COG2610	gluconate transmembrane transporter activity
GO498_17165	COG3265	gluconokinase activity
GO498_17170	COG1609	Transcriptional regulator
GO498_17185	COG1120	ATPase activity
GO498_17190	COG0500	methyltransferase
GO498_17195	COG0157	Belongs to the NadC ModD family
GO498_17240	COG4790	Type iii secretion
GO498_17260	COG1157	protein secretion by the type III secretion system
GO498_17270	COG4789	Type iii secretion
GO498_17285	COG2207	Transcriptional regulator
GO498_17325	COG0789	Transcriptional regulator
GO498_17340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO498_17365	COG4869	propanediol catabolic process
GO498_17370	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GO498_17375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GO498_17380	COG1882	Formate acetyltransferase
GO498_17390	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GO498_17395	COG1454	alcohol dehydrogenase
GO498_17395	COG1012	belongs to the aldehyde dehydrogenase family
GO498_17400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GO498_17405	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GO498_17410	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
GO498_17450	COG3188	usher protein
GO498_17455	COG3539	Fimbrial protein
GO498_17470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GO498_17475	COG1177	transmembrane transport
GO498_17480	COG1176	ABC-type spermidine putrescine transport system, permease component I
GO498_17500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO498_17510	COG0305	Participates in initiation and elongation during chromosome replication
GO498_17520	COG1448	Aminotransferase
GO498_17530	COG0814	amino acid
GO498_17535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO498_17545	COG0735	belongs to the Fur family
GO498_17550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO498_17555	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO498_17560	COG2937	Belongs to the GPAT DAPAT family
GO498_17565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO498_17570	COG3161	chorismate lyase activity
GO498_17575	COG0166	Belongs to the GPI family
GO498_17580	COG0527	aspartate kinase activity
GO498_17595	COG0646	methionine synthase
GO498_17595	COG1410	methionine synthase
GO498_17605	COG0129	dihydroxy-acid dehydratase activity
GO498_17610	COG0800	Aldolase
GO498_17620	COG2224	Isocitrate lyase
GO498_17625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GO498_17630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO498_17640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GO498_17670	COG0138	bifunctional purine biosynthesis protein purh
GO498_17675	COG0151	Belongs to the GarS family
GO498_17685	COG0776	regulation of translation
GO498_17690	COG3068	Protein conserved in bacteria
GO498_17695	COG1515	deoxyribonuclease V activity
GO498_17700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO498_17705	COG2816	NAD+ diphosphatase activity
GO498_17715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO498_17720	COG0352	thiamine-phosphate diphosphorylase activity
GO498_17725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO498_17730	COG2104	thiamine diphosphate biosynthetic process
GO498_17735	COG2022	thiamine diphosphate biosynthetic process
GO498_17745	COG5464	transposase or invertase
GO498_17750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO498_17755	COG0085	RNA polymerase activity
GO498_17760	COG0222	ribosome binding
GO498_17765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO498_17770	COG0081	regulation of translation
GO498_17775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GO498_17780	COG0250	Participates in transcription elongation, termination and antitermination
GO498_17785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO498_17795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO498_17800	COG0049	tRNA binding
GO498_17805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO498_17815	COG2923	Belongs to the DsrF TusC family
GO498_17820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GO498_17825	COG2964	Protein conserved in bacteria
GO498_17835	COG0545	Peptidyl-prolyl cis-trans isomerase
GO498_17840	COG2900	Belongs to the SlyX family
GO498_17845	COG1047	Peptidyl-prolyl cis-trans
GO498_17850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GO498_17860	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO498_17865	COG0488	(ABC) transporter
GO498_17870	COG0840	transmembrane signaling receptor activity
GO498_17875	COG0840	transmembrane signaling receptor activity
GO498_17880	COG0840	transmembrane signaling receptor activity
GO498_17895	COG0429	hydrolase of the alpha beta-hydrolase fold
GO498_17900	COG3089	Belongs to the UPF0270 family
GO498_17905	COG3954	Phosphoribulokinase
GO498_17910	COG1765	OsmC-like protein
GO498_17915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO498_17920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO498_17930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO498_17940	COG0242	peptide deformylase activity
GO498_17945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO498_17945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO498_17955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO498_17960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO498_17965	COG3084	Protein conserved in bacteria
GO498_17970	COG0746	molybdenum cofactor guanylyltransferase activity
GO498_17975	COG1763	Mo-molybdopterin cofactor biosynthetic process
GO498_17990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO498_17995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GO498_18005	COG1295	ribonuclease BN
GO498_18010	COG1942	4-Oxalocrotonate Tautomerase
GO498_18020	COG2199	diguanylate cyclase activity
GO498_18020	COG2200	EAL domain
GO498_18025	COG3210	domain, Protein
GO498_18030	COG4608	Belongs to the ABC transporter superfamily
GO498_18035	COG0444	Belongs to the ABC transporter superfamily
GO498_18040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO498_18045	COG0601	transmembrane transport
GO498_18050	COG0747	negative chemotaxis
GO498_18055	COG2831	hemolysin activation secretion protein
GO498_18070	COG5645	(Lipo)protein
GO498_18080	COG3977	Valine--pyruvate aminotransferase
GO498_18085	COG2818	Glycosylase
GO498_18090	COG0752	glycyl-tRNA synthetase alpha subunit
GO498_18095	COG0751	glycine-tRNA ligase activity
GO498_18120	COG0823	Involved in the tonB-independent uptake of proteins
GO498_18125	COG2860	membrane
GO498_18130	COG0194	GDP metabolic process
GO498_18135	COG1758	RNA polymerase activity
GO498_18140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO498_18145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO498_18150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO498_18155	COG0786	glutamate:sodium symporter activity
GO498_18160	COG2233	PERMEase
GO498_18165	COG2982	Protein involved in outer membrane biogenesis
GO498_18175	COG1187	pseudouridine synthase activity
GO498_18180	COG0456	acetyltransferase
GO498_18185	COG1490	D-aminoacyl-tRNA deacylase activity
GO498_18190	COG1011	Hydrolase
GO498_18230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO498_18250	COG2183	response to ionizing radiation
GO498_18255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO498_18260	COG0745	RESPONSE REGULATOR receiver
GO498_18265	COG2205	protein histidine kinase activity
GO498_18270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO498_18275	COG0573	inorganic phosphate transmembrane transporter activity
GO498_18280	COG0581	inorganic phosphate transmembrane transporter activity
GO498_18290	COG0704	Plays a role in the regulation of phosphate uptake
GO498_18295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO498_18305	COG0765	amino acid transport
GO498_18330	COG1136	(ABC) transporter
GO498_18345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO498_18350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO498_18355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO498_18360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO498_18370	COG0736	holo-[acyl-carrier-protein] synthase activity
GO498_18380	COG2252	PERMEase
GO498_18405	COG1918	ferrous iron import across plasma membrane
GO498_18410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GO498_18425	COG2267	carboxylic ester hydrolase activity
GO498_18430	COG1040	competence protein
GO498_18435	COG0316	Belongs to the HesB IscA family
GO498_18435	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO498_18440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO498_18445	COG0705	Rhomboid family
GO498_18450	COG1349	DNA-binding transcription factor activity
GO498_18455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO498_18460	COG3189	MarR family transcriptional regulator
GO498_18500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO498_18510	COG1069	ribulokinase activity
GO498_18520	COG1124	(ABC) transporter
GO498_18535	COG0601	transmembrane transport
GO498_18540	COG0747	negative chemotaxis
GO498_18545	COG1073	alpha beta
GO498_18545	COG2226	methyltransferase
GO498_18560	COG3394	polysaccharide catabolic process
GO498_18565	COG1486	melibiose metabolic process
GO498_18570	COG2169	Transcriptional regulator
GO498_18570	COG1917	Cupin 2, conserved barrel domain protein
GO498_18575	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO498_18580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO498_18585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO498_18590	COG4607	ABC-type enterochelin transport system periplasmic component
GO498_18595	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO498_18600	COG4605	iron ion homeostasis
GO498_18605	COG4604	ABC transporter, ATP-binding protein
GO498_18615	COG2271	Major facilitator Superfamily
GO498_18620	COG4948	Mandelate Racemase Muconate Lactonizing
GO498_18625	COG1802	Transcriptional regulator
GO498_18630	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_18635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_18640	COG0800	Aldolase
GO498_18660	COG1982	Orn Lys Arg decarboxylase major
GO498_18665	COG0531	amino acid
GO498_18675	COG0243	molybdopterin cofactor binding
GO498_18680	COG0437	4 iron, 4 sulfur cluster binding
GO498_18685	COG3302	dmso reductase anchor subunit
GO498_18690	COG1609	Transcriptional regulator
GO498_18700	COG2211	Major facilitator Superfamily
GO498_18705	COG1285	pathogenesis
GO498_18725	COG1737	Transcriptional regulator
GO498_18730	COG2731	YhcH YjgK YiaL family protein
GO498_18735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO498_18745	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GO498_18750	COG3383	formate dehydrogenase (NAD+) activity
GO498_18755	COG0733	neurotransmitter:sodium symporter activity
GO498_18760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO498_18765	COG1263	PTS System
GO498_18765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO498_18770	COG1737	Transcriptional regulator
GO498_18775	COG1278	Cold shock
GO498_18780	COG0564	pseudouridine synthase activity
GO498_18785	COG3122	Protein conserved in bacteria
GO498_18790	COG1403	HNH endonuclease
GO498_18800	COG3501	Rhs element vgr protein
GO498_18840	COG3188	usher protein
GO498_18875	COG0742	ribosomal rna small subunit methyltransferase
GO498_18880	COG1028	Short-chain dehydrogenase reductase Sdr
GO498_18890	COG0589	response to stress
GO498_18900	COG0306	phosphate transporter
GO498_18905	COG2081	HI0933 family
GO498_18910	COG1741	Belongs to the pirin family
GO498_18915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO498_18920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO498_18925	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO498_18935	COG0494	nUDIX hydrolase
GO498_18945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GO498_18965	COG4796	Type ii and iii secretion system protein
GO498_18970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO498_18975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO498_18990	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO498_18995	COG0546	phosphoglycolate phosphatase activity
GO498_19000	COG0180	Tryptophanyl-tRNA synthetase
GO498_19005	COG0675	Transposase, IS605 OrfB family
GO498_19010	COG1943	Transposase
GO498_19015	COG2258	MOSC domain
GO498_19020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO498_19025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO498_19030	COG3162	membrane
GO498_19035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO498_19040	COG2194	sulfuric ester hydrolase activity
GO498_19045	COG1556	Lactate utilization protein
GO498_19050	COG1139	Iron-sulfur cluster binding protein
GO498_19055	COG0247	lactate metabolic process
GO498_19080	COG2186	Transcriptional regulator
GO498_19090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO498_19095	COG0714	Associated with various cellular activities
GO498_19100	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GO498_19105	COG2502	aspartate--ammonia ligase
GO498_19110	COG1522	sequence-specific DNA binding
GO498_19115	COG0716	FMN binding
GO498_19120	COG0445	tRNA wobble uridine modification
GO498_19125	COG0357	Ribosomal RNA small subunit methyltransferase G
GO498_19130	COG3312	ion transport
GO498_19135	COG0356	it plays a direct role in the translocation of protons across the membrane
GO498_19145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO498_19150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO498_19155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GO498_19160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO498_19165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO498_19170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO498_19175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO498_19180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO498_19185	COG3842	ATPase activity
GO498_19190	COG1178	ABC-type Fe3 transport system permease component
GO498_19195	COG1840	ABC-type Fe3 transport system, periplasmic component
GO498_19200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO498_19215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO498_19225	COG1288	antiporter activity
GO498_19260	COG3188	usher protein
GO498_19285	COG3111	PFAM Bacterial OB fold (BOF) protein
GO498_19295	COG1940	carbohydrate kinase activity
GO498_19305	COG1215	transferase activity, transferring glycosyl groups
GO498_19315	COG0457	Tetratricopeptide repeat
GO498_19325	COG3706	GGDEF domain
GO498_19330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO498_19335	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GO498_19340	COG1368	sulfuric ester hydrolase activity
GO498_19345	COG3276	selenocysteine insertion sequence binding
GO498_19350	COG1921	L-seryl-tRNASec selenium transferase activity
GO498_19355	COG3058	Necessary for formate dehydrogenase activity
GO498_19360	COG2864	formate dehydrogenase
GO498_19365	COG0437	4 iron, 4 sulfur cluster binding
GO498_19375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO498_19390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO498_19395	COG0583	DNA-binding transcription factor activity
GO498_19435	COG3550	peptidyl-serine autophosphorylation
GO498_19450	COG3316	Transposase and inactivated derivatives
GO498_19490	COG0464	growth
GO498_19505	COG1074	ATP-dependent DNA helicase activity
GO498_19590	COG4974	Belongs to the 'phage' integrase family
GO498_19595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO498_19600	COG0706	membrane insertase activity
GO498_19605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO498_19610	COG0594	ribonuclease P activity
GO498_19615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO498_19640	COG3316	Transposase and inactivated derivatives
GO498_19670	COG3316	Transposase and inactivated derivatives
GO498_19785	COG0681	Belongs to the peptidase S26 family
GO498_19975	COG3316	Transposase and inactivated derivatives
GO498_19995	COG3316	Transposase and inactivated derivatives
GO498_20030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO498_20065	COG3316	Transposase and inactivated derivatives
GO498_20125	COG1357	PFAM Pentapeptide repeats (8 copies)
GO498_20130	COG3316	Transposase and inactivated derivatives
GO498_20140	COG3173	Aminoglycoside phosphotransferase
GO498_20150	COG3316	Transposase and inactivated derivatives
GO498_20160	COG3316	Transposase and inactivated derivatives
GO498_20260	COG3316	Transposase and inactivated derivatives
GO498_20320	COG2337	Toxic component of a toxin-antitoxin (TA) module
GO498_20325	COG2336	PFAM SpoVT AbrB
GO498_20330	COG1192	Involved in chromosome partitioning
GO498_20350	COG3157	Type VI secretion system effector, Hcp
GO498_20365	COG0629	single-stranded DNA binding
GO498_20375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO498_20380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair