locus-tag	class	description
GU243_00095	COG0358	DNA primase activity
GU243_00140	COG0741	lytic transglycosylase activity
GU243_00215	COG4974	Belongs to the 'phage' integrase family
GU243_00225	COG1280	lysine exporter protein (LysE YggA)
GU243_00240	COG3344	reverse transcriptase
GU243_00275	COG0179	Fumarylacetoacetate (FAA) hydrolase
GU243_00280	COG0251	oxidation-reduction process
GU243_00305	COG2211	Major facilitator Superfamily
GU243_00325	COG0747	negative chemotaxis
GU243_00335	COG0444	Belongs to the ABC transporter superfamily
GU243_00350	COG1285	pathogenesis
GU243_00360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GU243_00385	COG1940	carbohydrate kinase activity
GU243_00400	COG3328	transposase activity
GU243_00460	COG3850	Histidine kinase
GU243_00460	COG0642	Histidine kinase
GU243_00465	COG0745	RESPONSE REGULATOR receiver
GU243_00475	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
GU243_00480	COG0288	reversible hydration of carbon dioxide
GU243_00570	COG3340	Belongs to the peptidase S51 family
GU243_00580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GU243_00585	COG0346	lactoylglutathione lyase activity
GU243_00590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GU243_00635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GU243_00650	COG0251	oxidation-reduction process
GU243_00655	COG1921	L-seryl-tRNASec selenium transferase activity
GU243_00660	COG1414	Transcriptional regulator
GU243_00680	COG0395	ABC-type sugar transport system, permease component
GU243_00685	COG3842	ATPase activity
GU243_00695	COG0800	Aldolase
GU243_00770	COG1012	belongs to the aldehyde dehydrogenase family
GU243_00775	COG2814	Major facilitator Superfamily
GU243_00850	COG0765	amino acid transport
GU243_00855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GU243_00885	COG3835	regulator
GU243_00920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GU243_00930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GU243_00945	COG1175	transmembrane transport
GU243_00950	COG0395	ABC-type sugar transport system, permease component
GU243_00955	COG1486	melibiose metabolic process
GU243_00970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GU243_01105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GU243_01130	COG2814	Major facilitator Superfamily
GU243_01140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GU243_01150	COG0297	glycogen (starch) synthase activity
GU243_01170	COG0052	Belongs to the universal ribosomal protein uS2 family
GU243_01175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GU243_01180	COG0528	UMP kinase activity
GU243_01185	COG0233	cytoplasmic translational termination
GU243_01200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GU243_01215	COG3275	phosphorelay sensor kinase activity
GU243_01225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GU243_01235	COG3959	Transketolase, thiamine diphosphate binding domain
GU243_01260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GU243_01270	COG5002	protein histidine kinase activity
GU243_01275	COG0745	RESPONSE REGULATOR receiver
GU243_01325	COG0022	dehydrogenase e1 component
GU243_01330	COG0508	dehydrogenase complex catalyzes the overall conversion of
GU243_01340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GU243_01350	COG1960	acyl-CoA dehydrogenase activity
GU243_01385	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GU243_01390	COG0750	zinc metalloprotease
GU243_01415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GU243_01425	COG1309	transcriptional regulator
GU243_01440	COG0442	prolyl-tRNA aminoacylation
GU243_01470	COG0779	Required for maturation of 30S ribosomal subunits
GU243_01490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GU243_01500	COG0590	tRNA wobble adenosine to inosine editing
GU243_01515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GU243_01530	COG0196	riboflavin kinase activity
GU243_01535	COG3483	tryptophan 2,3-dioxygenase activity
GU243_01540	COG3844	kynureninase activity
GU243_01545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GU243_01555	COG0612	Peptidase, M16
GU243_01605	COG0521	Mo-molybdopterin cofactor biosynthetic process
GU243_01615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GU243_01640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GU243_01645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GU243_01650	COG1674	ftsk spoiiie
GU243_01660	COG1058	Belongs to the CinA family
GU243_01660	COG1546	Belongs to the CinA family
GU243_01665	COG1396	sequence-specific DNA binding
GU243_01680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GU243_01685	COG2137	regulation of response to DNA damage stimulus
GU243_01690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GU243_01695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GU243_01700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GU243_01705	COG2813	Specifically methylates the guanine in position
GU243_01710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GU243_01720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GU243_01730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GU243_01735	COG0131	Imidazoleglycerol-phosphate dehydratase
GU243_01740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GU243_01745	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GU243_01765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GU243_01770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GU243_01775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GU243_01780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GU243_01795	COG2814	Major facilitator Superfamily
GU243_01800	COG2816	NAD+ diphosphatase activity
GU243_01820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GU243_01825	COG0072	phenylalanine-tRNA ligase activity
GU243_01825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GU243_01855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GU243_01860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GU243_01865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GU243_01870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GU243_01875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GU243_01880	COG1438	arginine binding
GU243_01885	COG0137	argininosuccinate synthase activity
GU243_01890	COG0165	Argininosuccinate lyase
GU243_01895	COG0259	pyridoxamine-phosphate oxidase activity
GU243_01905	COG2169	Transcriptional regulator
GU243_01905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GU243_01915	COG2094	Belongs to the DNA glycosylase MPG family
GU243_01920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GU243_01930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GU243_01960	COG0647	UMP catabolic process
GU243_01975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GU243_01980	COG0497	DNA recombination
GU243_01985	COG0504	CTP synthase activity
GU243_02010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GU243_02015	COG2079	MmgE PrpD family protein
GU243_02030	COG1953	Uracil, thiamine, allantoin
GU243_02035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GU243_02040	COG4565	transcriptional regulatory protein
GU243_02045	COG3290	protein histidine kinase activity
GU243_02050	COG1301	dicarboxylic acid transport
GU243_02060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GU243_02065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GU243_02080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GU243_02090	COG1160	GTP binding
GU243_02100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GU243_02110	COG0509	glycine decarboxylation via glycine cleavage system
GU243_02150	COG1940	carbohydrate kinase activity
GU243_02175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GU243_02180	COG2815	serine threonine protein kinase
GU243_02180	COG0515	serine threonine protein kinase
GU243_02185	COG3942	CHAP domain
GU243_02185	COG1388	LysM domain
GU243_02205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GU243_02215	COG2001	Belongs to the MraZ family
GU243_02220	COG0275	rRNA processing
GU243_02230	COG0768	penicillin binding
GU243_02240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GU243_02250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GU243_02255	COG0772	Belongs to the SEDS family
GU243_02260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GU243_02265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GU243_02275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GU243_02285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GU243_02290	COG1799	cell septum assembly
GU243_02315	COG0587	DNA-directed DNA polymerase activity
GU243_02330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GU243_02335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GU243_02355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GU243_02360	COG0174	glutamine synthetase
GU243_02455	COG0582	viral genome integration into host DNA
GU243_02480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GU243_02485	COG0321	lipoyl(octanoyl) transferase activity
GU243_02495	COG1090	epimerase
GU243_02515	COG0508	dehydrogenase complex catalyzes the overall conversion of
GU243_02520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GU243_02525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GU243_02545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GU243_02570	COG1271	oxidase subunit
GU243_02575	COG1294	oxidase, subunit
GU243_02580	COG4988	ABC transporter
GU243_02590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GU243_02595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GU243_02595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GU243_02625	COG0756	dUTP diphosphatase activity
GU243_02650	COG0569	domain protein
GU243_02660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GU243_02665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GU243_02675	COG3557	Belongs to the UPF0374 family
GU243_02685	COG0667	Aldo Keto reductase
GU243_02730	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GU243_02755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GU243_02770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GU243_02835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GU243_02845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GU243_02870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GU243_02875	COG0140	phosphoribosyl-ATP diphosphatase activity
GU243_02880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GU243_02895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GU243_02915	COG0134	indole-3-glycerol-phosphate synthase activity
GU243_02920	COG0133	tryptophan synthase activity
GU243_02925	COG0159	tryptophan synthase activity
GU243_02930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GU243_03000	COG1196	nuclear chromosome segregation
GU243_03030	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_03055	COG1309	transcriptional regulator
GU243_03060	COG0300	oxidoreductase activity
GU243_03120	COG0506	proline dehydrogenase activity
GU243_03135	COG0765	amino acid transport
GU243_03140	COG0765	amino acid transport
GU243_03160	COG0583	DNA-binding transcription factor activity
GU243_03165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GU243_03210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GU243_03215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GU243_03225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GU243_03235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GU243_03240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GU243_03295	COG1131	(ABC) transporter
GU243_03315	COG2197	response regulator
GU243_03330	COG1733	regulation of RNA biosynthetic process
GU243_03335	COG1595	DNA-templated transcription, initiation
GU243_03395	COG0583	DNA-binding transcription factor activity
GU243_03405	COG1595	DNA-templated transcription, initiation
GU243_03415	COG0463	Glycosyl transferase, family 2
GU243_03455	COG3654	unkown
GU243_03490	COG4565	transcriptional regulatory protein
GU243_03495	COG3290	protein histidine kinase activity
GU243_03500	COG1116	anion transmembrane transporter activity
GU243_03570	COG2986	histidine ammonia-lyase
GU243_03580	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_03590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GU243_03620	COG1414	Transcriptional regulator
GU243_03630	COG1396	sequence-specific DNA binding
GU243_03635	COG0492	ferredoxin-NADP+ reductase activity
GU243_03640	COG2226	methyltransferase
GU243_03670	COG0589	response to stress
GU243_03730	COG2217	Heavy metal translocating P-type atpase
GU243_03765	COG1250	3-hydroxyacyl-CoA dehydrogenase
GU243_03775	COG1960	acyl-CoA dehydrogenase activity
GU243_03780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GU243_03785	COG1960	acyl-CoA dehydrogenase activity
GU243_03790	COG0477	Major facilitator Superfamily
GU243_03795	COG0583	DNA-binding transcription factor activity
GU243_03800	COG3408	Glycogen debranching enzyme
GU243_03815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GU243_03840	COG3971	2-oxopent-4-enoate hydratase activity
GU243_03860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GU243_03865	COG2017	converts alpha-aldose to the beta-anomer
GU243_03875	COG0251	oxidation-reduction process
GU243_03880	COG0477	Major facilitator Superfamily
GU243_03890	COG0028	Belongs to the TPP enzyme family
GU243_03895	COG1012	belongs to the aldehyde dehydrogenase family
GU243_03910	COG1082	Xylose isomerase domain protein TIM barrel
GU243_03915	COG0149	triose-phosphate isomerase activity
GU243_03920	COG0698	ribose 5-phosphate isomerase
GU243_03925	COG2376	Dihydroxyacetone kinase
GU243_03935	COG2186	Transcriptional regulator
GU243_03950	COG2031	fatty acid transporter
GU243_03970	COG1162	GTPase activity
GU243_03985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GU243_04010	COG0405	Gamma-glutamyltransferase
GU243_04020	COG1643	Atp-dependent helicase
GU243_04035	COG4566	intracellular signal transduction
GU243_04050	COG0009	L-threonylcarbamoyladenylate synthase
GU243_04085	COG0179	Fumarylacetoacetate (FAA) hydrolase
GU243_04100	COG2814	Major facilitator Superfamily
GU243_04105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GU243_04130	COG2050	protein possibly involved in aromatic compounds catabolism
GU243_04145	COG4552	Acetyltransferase involved in intracellular survival and related
GU243_04155	COG0539	negative regulation of cytoplasmic translation
GU243_04165	COG1739	Uncharacterized protein family UPF0029
GU243_04185	COG0477	Major facilitator Superfamily
GU243_04210	COG4106	trans-aconitate 2-methyltransferase activity
GU243_04235	COG0546	phosphoglycolate phosphatase activity
GU243_04240	COG0204	Acyl-transferase
GU243_04240	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_04250	COG1660	Displays ATPase and GTPase activities
GU243_04260	COG1481	regulation of sporulation
GU243_04265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GU243_04270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GU243_04275	COG0126	phosphoglycerate kinase activity
GU243_04280	COG0149	triose-phosphate isomerase activity
GU243_04285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GU243_04295	COG0363	glucosamine-6-phosphate deaminase activity
GU243_04310	COG0166	Belongs to the GPI family
GU243_04315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GU243_04325	COG0109	protoheme IX farnesyltransferase activity
GU243_04330	COG1612	heme a metabolic process
GU243_04355	COG0719	Fe-S assembly protein
GU243_04365	COG0396	ATPase activity
GU243_04370	COG2151	metal-sulfur cluster biosynthetic enzyme
GU243_04380	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_04395	COG1122	ATPase activity
GU243_04400	COG1268	BioY protein
GU243_04405	COG0488	(ABC) transporter
GU243_04430	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_04435	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_04445	COG3830	Belongs to the UPF0237 family
GU243_04445	COG0560	Phosphoserine phosphatase
GU243_04450	COG1119	ATPase activity
GU243_04465	COG0254	rRNA binding
GU243_04470	COG0095	Lipoate-protein ligase
GU243_04480	COG2855	membrane
GU243_04510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GU243_04515	COG0297	glycogen (starch) synthase activity
GU243_04530	COG0183	Belongs to the thiolase family
GU243_04535	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_04585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GU243_04605	COG0667	Aldo Keto reductase
GU243_04610	COG1968	undecaprenyl-diphosphatase activity
GU243_04615	COG0215	cysteine-tRNA ligase activity
GU243_04625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GU243_04630	COG0517	IMP dehydrogenase activity
GU243_04630	COG1994	Peptidase M50
GU243_04640	COG1222	aaa ATPase
GU243_04645	COG4122	O-methyltransferase activity
GU243_04655	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GU243_04660	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GU243_04665	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GU243_04670	COG0545	Peptidyl-prolyl cis-trans isomerase
GU243_04690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GU243_04695	COG0805	protein transport
GU243_04705	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GU243_04710	COG1216	Glycosyl transferase, family 2
GU243_04735	COG4946	Tricorn protease homolog
GU243_04735	COG1506	peptidase
GU243_04735	COG0823	Involved in the tonB-independent uptake of proteins
GU243_04740	COG0242	peptide deformylase activity
GU243_04750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GU243_04760	COG3424	synthase
GU243_04795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GU243_04800	COG1845	cytochrome c oxidase, subunit III
GU243_04805	COG2010	Cytochrome c
GU243_04815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GU243_04825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GU243_04835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GU243_04840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GU243_04850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GU243_04865	COG2267	carboxylic ester hydrolase activity
GU243_04875	COG1381	Involved in DNA repair and RecF pathway recombination
GU243_04880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GU243_04885	COG3590	peptidase
GU243_04890	COG1316	TRANSCRIPTIONal
GU243_04895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GU243_04905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GU243_04920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GU243_04925	COG0484	heat shock protein binding
GU243_04930	COG1420	regulation of RNA biosynthetic process
GU243_04960	COG0268	Binds directly to 16S ribosomal RNA
GU243_04980	COG1307	EDD domain protein, DegV family
GU243_04985	COG0495	leucyl-tRNA aminoacylation
GU243_04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GU243_05010	COG0656	L-ascorbic acid biosynthetic process
GU243_05020	COG0438	transferase activity, transferring glycosyl groups
GU243_05045	COG0194	GDP metabolic process
GU243_05050	COG0194	GDP metabolic process
GU243_05060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GU243_05065	COG0505	Belongs to the CarA family
GU243_05075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GU243_05080	COG0540	Belongs to the ATCase OTCase family
GU243_05085	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GU243_05095	COG0149	triose-phosphate isomerase activity
GU243_05100	COG2271	Major facilitator Superfamily
GU243_05105	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_05110	COG1250	3-hydroxyacyl-CoA dehydrogenase
GU243_05115	COG0698	ribose 5-phosphate isomerase
GU243_05120	COG2376	Dihydroxyacetone kinase
GU243_05135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GU243_05140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GU243_05150	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GU243_05155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GU243_05160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GU243_05165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GU243_05175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GU243_05180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GU243_05195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GU243_05210	COG3384	dioxygenase
GU243_05230	COG2040	homocysteine
GU243_05245	COG1414	Transcriptional regulator
GU243_05250	COG1414	Transcriptional regulator
GU243_05260	COG0833	amino acid
GU243_05265	COG0460	homoserine dehydrogenase
GU243_05270	COG1012	belongs to the aldehyde dehydrogenase family
GU243_05330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GU243_05340	COG0124	histidyl-tRNA synthetase
GU243_05360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GU243_05365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GU243_05370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GU243_05385	COG0632	four-way junction helicase activity
GU243_05390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GU243_05395	COG0217	transcriptional regulatory protein
GU243_05400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GU243_05425	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GU243_05430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GU243_05440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GU243_05445	COG0587	DNA-directed DNA polymerase activity
GU243_05460	COG0077	Prephenate dehydratase
GU243_05460	COG1605	Chorismate mutase
GU243_05470	COG2135	peptidase activity
GU243_05555	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GU243_05570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GU243_05575	COG1846	Transcriptional regulator
GU243_05585	COG1012	belongs to the aldehyde dehydrogenase family
GU243_05590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GU243_05595	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_05630	COG0723	plastoquinol--plastocyanin reductase activity
GU243_05630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GU243_05640	COG0431	NADPH-dependent FMN reductase
GU243_05665	COG2161	toxin-antitoxin pair type II binding
GU243_05680	COG2161	toxin-antitoxin pair type II binding
GU243_05690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GU243_05695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GU243_05700	COG1780	Probably involved in ribonucleotide reductase function
GU243_05715	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_05725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GU243_05740	COG0583	DNA-binding transcription factor activity
GU243_05750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GU243_05785	COG0714	Associated with various cellular activities
GU243_05800	COG1175	transmembrane transport
GU243_05810	COG1940	carbohydrate kinase activity
GU243_05820	COG0492	ferredoxin-NADP+ reductase activity
GU243_05825	COG2824	Alkylphosphonate utilization operon protein PhnA
GU243_05830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GU243_05845	COG0799	negative regulation of ribosome biogenesis
GU243_05855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GU243_05865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GU243_05870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GU243_05875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GU243_05880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GU243_05885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GU243_05890	COG0351	phosphomethylpyrimidine kinase
GU243_05890	COG0352	thiamine-phosphate diphosphorylase activity
GU243_05890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GU243_05915	COG0285	dihydrofolate synthase activity
GU243_05920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GU243_05925	COG0584	glycerophosphoryl diester phosphodiesterase
GU243_05940	COG3189	MarR family transcriptional regulator
GU243_05945	COG0525	valine-tRNA ligase activity
GU243_05950	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GU243_05955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GU243_05960	COG0740	serine-type endopeptidase activity
GU243_05965	COG0740	serine-type endopeptidase activity
GU243_06015	COG0668	transmembrane transport
GU243_06030	COG1946	Acyl-CoA thioesterase
GU243_06180	COG0673	inositol 2-dehydrogenase activity
GU243_06190	COG0657	acetylesterase activity
GU243_06190	COG2755	lipolytic protein G-D-S-L family
GU243_06220	COG0242	peptide deformylase activity
GU243_06245	COG0330	HflC and HflK could
GU243_06250	COG3022	response to hydroperoxide
GU243_06260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GU243_06265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GU243_06275	COG1045	serine acetyltransferase
GU243_06280	COG0300	oxidoreductase activity
GU243_06285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GU243_06295	COG1063	alcohol dehydrogenase
GU243_06300	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_06310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GU243_06315	COG0477	Major facilitator Superfamily
GU243_06350	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GU243_06365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GU243_06370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GU243_06375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GU243_06385	COG4974	Belongs to the 'phage' integrase family
GU243_06400	COG0792	nuclease activity
GU243_06410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GU243_06420	COG0681	Belongs to the peptidase S26 family
GU243_06425	COG0335	large ribosomal subunit rRNA binding
GU243_06430	COG0336	Belongs to the RNA methyltransferase TrmD family
GU243_06435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GU243_06440	COG1837	Belongs to the UPF0109 family
GU243_06445	COG0228	four-way junction DNA binding
GU243_06475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GU243_06490	COG0477	Major facilitator Superfamily
GU243_06505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GU243_06510	COG0571	ribonuclease III activity
GU243_06515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GU243_06525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GU243_06540	COG0742	ribosomal rna small subunit methyltransferase
GU243_06550	COG1461	Dihydroxyacetone kinase
GU243_06565	COG1181	Belongs to the D-alanine--D-alanine ligase family
GU243_06570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GU243_06580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GU243_06585	COG0066	3-isopropylmalate dehydratase activity
GU243_06590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GU243_06595	COG1414	Transcriptional regulator
GU243_06635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GU243_06640	COG0179	Fumarylacetoacetate (FAA) hydrolase
GU243_06645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GU243_06655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GU243_06660	COG0473	3-isopropylmalate dehydrogenase activity
GU243_06680	COG0577	efflux transmembrane transporter activity
GU243_06680	COG1136	(ABC) transporter
GU243_06690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GU243_06695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GU243_06700	COG0440	acetolactate synthase activity
GU243_06710	COG0129	dihydroxy-acid dehydratase activity
GU243_06715	COG0088	Forms part of the polypeptide exit tunnel
GU243_06755	COG0747	negative chemotaxis
GU243_06780	COG1305	Transglutaminase-like
GU243_06805	COG1104	cysteine desulfurase activity
GU243_06815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GU243_06820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GU243_06830	COG1522	sequence-specific DNA binding
GU243_06835	COG1113	amino acid transport
GU243_06845	COG0022	dehydrogenase e1 component
GU243_06870	COG0477	Major facilitator Superfamily
GU243_06875	COG1414	Transcriptional regulator
GU243_06885	COG0419	ATPase involved in DNA repair
GU243_06890	COG0420	3'-5' exonuclease activity
GU243_06915	COG0586	Pfam SNARE associated Golgi protein
GU243_06920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GU243_06925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GU243_06930	COG1234	tRNA 3'-trailer cleavage
GU243_06935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GU243_06945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GU243_06950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GU243_06955	COG1335	isochorismatase
GU243_06970	COG0363	glucosamine-6-phosphate deaminase activity
GU243_06985	COG1902	pentaerythritol trinitrate reductase activity
GU243_07015	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GU243_07025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GU243_07030	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GU243_07040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GU243_07045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GU243_07050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GU243_07055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GU243_07060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GU243_07065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GU243_07070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GU243_07110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GU243_07130	COG0460	homoserine dehydrogenase
GU243_07140	COG0018	arginyl-trna synthetase
GU243_07155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GU243_07155	COG1017	nitric oxide dioxygenase activity
GU243_07185	COG3485	protocatechuate 3,4-dioxygenase
GU243_07195	COG0583	DNA-binding transcription factor activity
GU243_07200	COG4638	Rieske (2fe-2S)
GU243_07220	COG2814	Major facilitator Superfamily
GU243_07230	COG1643	Atp-dependent helicase
GU243_07235	COG0537	adenosine 5'-monophosphoramidase activity
GU243_07240	COG1064	alcohol dehydrogenase
GU243_07250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GU243_07265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GU243_07270	COG1121	(ABC) transporter
GU243_07275	COG0803	Belongs to the bacterial solute-binding protein 9 family
GU243_07290	COG0508	dehydrogenase complex catalyzes the overall conversion of
GU243_07290	COG0567	Dehydrogenase, E1 component
GU243_07320	COG1595	DNA-templated transcription, initiation
GU243_07330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GU243_07340	COG0483	inositol monophosphate 1-phosphatase activity
GU243_07360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GU243_07365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GU243_07385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GU243_07400	COG2884	Cell division ATP-binding protein ftsE
GU243_07405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GU243_07470	COG1088	dTDP-glucose 4,6-dehydratase activity
GU243_07475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GU243_07495	COG1216	Glycosyl transferase, family 2
GU243_07505	COG0463	Glycosyl transferase, family 2
GU243_07520	COG1215	transferase activity, transferring glycosyl groups
GU243_07605	COG2902	Dehydrogenase
GU243_07640	COG0653	protein targeting
GU243_07645	COG3214	Protein conserved in bacteria
GU243_07650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GU243_07665	COG5401	PFAM Sporulation and spore germination
GU243_07670	COG5002	protein histidine kinase activity
GU243_07675	COG0745	RESPONSE REGULATOR receiver
GU243_07695	COG0714	Associated with various cellular activities
GU243_07725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GU243_07730	COG0601	transmembrane transport
GU243_07775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GU243_07780	COG1595	DNA-templated transcription, initiation
GU243_07800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GU243_07810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GU243_07820	COG1842	Phage shock protein A
GU243_07845	COG1615	UPF0182 protein
GU243_07850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GU243_07860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GU243_07905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GU243_07915	COG1126	abc transporter atp-binding protein
GU243_07920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GU243_07930	COG0113	porphobilinogen synthase activity
GU243_07940	COG0181	hydroxymethylbilane synthase activity
GU243_07965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GU243_07970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GU243_07995	COG2154	pterin-4-alpha-carbinolamine dehydratase
GU243_08000	COG2022	thiamine diphosphate biosynthetic process
GU243_08010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GU243_08010	COG2022	thiamine diphosphate biosynthetic process
GU243_08015	COG0352	thiamine-phosphate diphosphorylase activity
GU243_08020	COG0557	exoribonuclease II activity
GU243_08025	COG0513	Belongs to the DEAD box helicase family
GU243_08030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GU243_08040	COG0006	proline dipeptidase activity
GU243_08050	COG1175	transmembrane transport
GU243_08055	COG0395	ABC-type sugar transport system, permease component
GU243_08080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GU243_08090	COG1595	DNA-templated transcription, initiation
GU243_08095	COG4122	O-methyltransferase activity
GU243_08115	COG1611	Belongs to the LOG family
GU243_08120	COG1126	abc transporter atp-binding protein
GU243_08125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GU243_08130	COG0765	amino acid transport
GU243_08135	COG0765	amino acid transport
GU243_08140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GU243_08145	COG2171	N-acyltransferase activity
GU243_08160	COG3226	Transcriptional regulator
GU243_08205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GU243_08255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GU243_08325	COG3655	Transcriptional regulator
GU243_08370	COG0745	RESPONSE REGULATOR receiver
GU243_08450	COG1302	Protein conserved in bacteria
GU243_08525	COG1278	Cold shock
GU243_08580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GU243_08585	COG3387	PFAM Glycoside hydrolase 15-related
GU243_08600	COG0574	Belongs to the PEP-utilizing enzyme family
GU243_08600	COG3848	Pyruvate phosphate dikinase
GU243_08745	COG0012	GTP binding
GU243_08750	COG1322	Protein conserved in bacteria
GU243_08755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GU243_08765	COG1570	exodeoxyribonuclease VII activity
GU243_08770	COG1722	exodeoxyribonuclease VII activity
GU243_08775	COG2326	polyphosphate kinase activity
GU243_08795	COG1174	glycine betaine transport
GU243_08810	COG2971	BadF BadG BcrA BcrD
GU243_08815	COG0583	DNA-binding transcription factor activity
GU243_08820	COG2814	Major facilitator Superfamily
GU243_08845	COG0598	Magnesium transport protein CorA
GU243_08850	COG0488	(ABC) transporter
GU243_08855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GU243_08860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GU243_08865	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GU243_08885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GU243_08930	COG0732	type I restriction modification DNA specificity domain
GU243_09045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GU243_09075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GU243_09075	COG0519	Catalyzes the synthesis of GMP from XMP
GU243_09095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GU243_09100	COG0516	GMP reductase activity
GU243_09125	COG1793	dna ligase
GU243_09140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GU243_09155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GU243_09160	COG1472	Belongs to the glycosyl hydrolase 3 family
GU243_09165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GU243_09170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GU243_09185	COG0802	atpase or kinase
GU243_09190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GU243_09200	COG1486	melibiose metabolic process
GU243_09210	COG0438	transferase activity, transferring glycosyl groups
GU243_09225	COG1260	myo-inositol-1-phosphate synthase
GU243_09230	COG0667	Aldo Keto reductase
GU243_09260	COG0736	holo-[acyl-carrier-protein] synthase activity
GU243_09275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GU243_09285	COG1072	(Pantothenic acid kinase))
GU243_09290	COG1876	peptidase activity
GU243_09295	COG1970	mechanosensitive ion channel activity
GU243_09305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GU243_09315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GU243_09320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GU243_09325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GU243_09360	COG2894	cell division
GU243_09400	COG1192	Involved in chromosome partitioning
GU243_09425	COG0745	RESPONSE REGULATOR receiver
GU243_09435	COG0101	tRNA pseudouridine synthase activity
GU243_09440	COG0203	ribosomal protein L17
GU243_09445	COG0202	RNA polymerase activity
GU243_09450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GU243_09455	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GU243_09460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GU243_09465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GU243_09495	COG0563	adenylate kinase activity
GU243_09510	COG1841	ribosomal large subunit assembly
GU243_09515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GU243_09525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GU243_09530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GU243_09535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GU243_09540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GU243_09545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GU243_09560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GU243_09565	COG0255	Belongs to the universal ribosomal protein uL29 family
GU243_09570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GU243_09575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GU243_09580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GU243_09585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GU243_09590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GU243_09595	COG0089	rRNA binding
GU243_09600	COG0088	Forms part of the polypeptide exit tunnel
GU243_09605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GU243_09610	COG0051	transcription antitermination factor activity, RNA binding
GU243_09625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GU243_09630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GU243_09635	COG0049	tRNA binding
GU243_09640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GU243_09645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GU243_09650	COG0085	RNA polymerase activity
GU243_09660	COG0183	Belongs to the thiolase family
GU243_09665	COG0442	prolyl-tRNA aminoacylation
GU243_09670	COG0222	ribosome binding
GU243_09675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GU243_09690	COG0081	regulation of translation
GU243_09695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GU243_09715	COG0436	Aminotransferase
GU243_09720	COG2197	response regulator
GU243_09765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GU243_09775	COG3485	protocatechuate 3,4-dioxygenase
GU243_09785	COG0745	RESPONSE REGULATOR receiver
GU243_09790	COG0456	acetyltransferase
GU243_09795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GU243_09805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GU243_09835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GU243_09840	COG0738	Major facilitator superfamily
GU243_09850	COG2030	dehydratase
GU243_09860	COG0659	secondary active sulfate transmembrane transporter activity
GU243_09875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GU243_09885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GU243_09910	COG3848	Pyruvate phosphate dikinase
GU243_09910	COG0574	Belongs to the PEP-utilizing enzyme family
GU243_09915	COG4989	oxidoreductase activity
GU243_09920	COG0366	Alpha amylase catalytic
GU243_09925	COG0395	ABC-type sugar transport system, permease component
GU243_09930	COG1175	transmembrane transport
GU243_09940	COG1940	carbohydrate kinase activity
GU243_09950	COG0702	epimerase
GU243_09960	COG0706	membrane insertase activity
GU243_09990	COG0754	glutathionylspermidine amidase activity
GU243_10015	COG1175	transmembrane transport
GU243_10020	COG0395	ABC-type sugar transport system, permease component
GU243_10065	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_10075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GU243_10085	COG1131	(ABC) transporter
GU243_10100	COG1388	LysM domain
GU243_10100	COG3942	CHAP domain
GU243_10120	COG1666	GTP binding
GU243_10125	COG0501	Belongs to the peptidase M48B family
GU243_10155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GU243_10160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GU243_10175	COG1414	Transcriptional regulator
GU243_10185	COG0800	Aldolase
GU243_10190	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_10205	COG0477	Major facilitator Superfamily
GU243_10210	COG0531	amino acid
GU243_10255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GU243_10260	COG3693	PFAM glycoside hydrolase, family 10
GU243_10275	COG1216	Glycosyl transferase, family 2
GU243_10290	COG1012	belongs to the aldehyde dehydrogenase family
GU243_10310	COG2186	Transcriptional regulator
GU243_10330	COG1648	precorrin-2 dehydrogenase activity
GU243_10330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GU243_10350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GU243_10355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GU243_10380	COG0175	sulfate reduction
GU243_10385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GU243_10395	COG2860	membrane
GU243_10420	COG2226	methyltransferase
GU243_10425	COG1063	alcohol dehydrogenase
GU243_10430	COG0477	Major facilitator Superfamily
GU243_10440	COG1169	isochorismate synthase
GU243_10450	COG0765	amino acid transport
GU243_10455	COG1126	abc transporter atp-binding protein
GU243_10460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GU243_10470	COG4948	Mandelate Racemase Muconate Lactonizing
GU243_10475	COG0598	Magnesium transport protein CorA
GU243_10480	COG2132	Multicopper oxidase
GU243_10530	COG0395	ABC-type sugar transport system, permease component
GU243_10535	COG1175	transmembrane transport
GU243_10620	COG1309	transcriptional regulator
GU243_10655	COG2329	Antibiotic biosynthesis monooxygenase
GU243_10665	COG1473	amidohydrolase
GU243_10710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GU243_10720	COG1086	Polysaccharide biosynthesis protein
GU243_10725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GU243_10740	COG0489	protein tyrosine kinase activity
GU243_10840	COG0508	dehydrogenase complex catalyzes the overall conversion of
GU243_10845	COG0022	dehydrogenase e1 component
GU243_10885	COG2755	lipolytic protein G-D-S-L family
GU243_10885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GU243_10935	COG3344	reverse transcriptase
GU243_10940	COG2826	transposase and inactivated derivatives, IS30 family
GU243_10975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GU243_10980	COG0489	protein tyrosine kinase activity
GU243_10990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GU243_11010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GU243_11015	COG1024	Enoyl-CoA hydratase
GU243_11020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GU243_11025	COG2151	metal-sulfur cluster biosynthetic enzyme
GU243_11030	COG3396	Phenylacetate-CoA oxygenase
GU243_11035	COG3460	Phenylacetate-CoA oxygenase
GU243_11075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GU243_11095	COG1937	Protein conserved in bacteria
GU243_11170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GU243_11175	COG2186	Transcriptional regulator
GU243_11180	COG0531	amino acid
GU243_11200	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_11220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GU243_11225	COG0747	negative chemotaxis
GU243_11230	COG0601	transmembrane transport
GU243_11250	COG1113	amino acid transport
GU243_11260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GU243_11270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GU243_11275	COG0509	glycine decarboxylation via glycine cleavage system
GU243_11280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GU243_11305	COG2217	Heavy metal translocating P-type atpase
GU243_11310	COG2217	Heavy metal translocating P-type atpase
GU243_11330	COG0739	heme binding
GU243_11340	COG1309	transcriptional regulator
GU243_11360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GU243_11375	COG1595	DNA-templated transcription, initiation
GU243_11390	COG1316	TRANSCRIPTIONal
GU243_11460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GU243_11490	COG0857	belongs to the CobB CobQ family
GU243_11490	COG0280	phosphate acetyltransferase
GU243_11495	COG2050	protein possibly involved in aromatic compounds catabolism
GU243_11505	COG0477	Major facilitator Superfamily
GU243_11520	COG1012	belongs to the aldehyde dehydrogenase family
GU243_11520	COG2030	dehydratase
GU243_11525	COG2050	protein possibly involved in aromatic compounds catabolism
GU243_11555	COG1250	3-hydroxyacyl-CoA dehydrogenase
GU243_11560	COG1024	Enoyl-CoA hydratase
GU243_11565	COG0183	Belongs to the thiolase family
GU243_11580	COG3237	CsbD-like
GU243_11595	COG2146	nitrite reductase [NAD(P)H] activity
GU243_11600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GU243_11610	COG0488	(ABC) transporter
GU243_11625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GU243_11640	COG1266	CAAX protease self-immunity
GU243_11650	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GU243_11685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GU243_11695	COG0785	Cytochrome C biogenesis protein
GU243_11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GU243_11705	COG0406	alpha-ribazole phosphatase activity
GU243_11725	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GU243_11750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GU243_11755	COG3458	cephalosporin-C deacetylase activity
GU243_11765	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_11765	COG3347	Dehydrogenase
GU243_11775	COG3254	rhamnose metabolic process
GU243_11780	COG1609	Transcriptional regulator
GU243_11800	COG0395	ABC-type sugar transport system, permease component
GU243_11810	COG1653	transport
GU243_11820	COG1874	Beta-galactosidase
GU243_11825	COG5578	integral membrane protein
GU243_11830	COG0673	inositol 2-dehydrogenase activity
GU243_11855	COG0395	ABC-type sugar transport system, permease component
GU243_11860	COG1175	transmembrane transport
GU243_11895	COG1609	Transcriptional regulator
GU243_11900	COG0366	Alpha amylase catalytic
GU243_11900	COG1470	cell adhesion involved in biofilm formation
GU243_11920	COG1940	carbohydrate kinase activity
GU243_11930	COG4209	transmembrane transport
GU243_11935	COG0395	ABC-type sugar transport system, permease component
GU243_11950	COG0673	inositol 2-dehydrogenase activity
GU243_11965	COG0395	ABC-type sugar transport system, permease component
GU243_11970	COG1175	transmembrane transport
GU243_12005	COG3328	transposase activity
GU243_12065	COG2826	transposase and inactivated derivatives, IS30 family
GU243_12075	COG4948	Mandelate Racemase Muconate Lactonizing
GU243_12080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GU243_12090	COG0673	inositol 2-dehydrogenase activity
GU243_12100	COG1802	Transcriptional regulator
GU243_12110	COG0640	Transcriptional regulator
GU243_12115	COG0123	including yeast histone deacetylase and acetoin utilization protein
GU243_12120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GU243_12125	COG0569	domain protein
GU243_12130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GU243_12135	COG0248	Ppx GppA phosphatase
GU243_12145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GU243_12145	COG1754	DNA topoisomerase type I activity
GU243_12150	COG2890	protein-(glutamine-N5) methyltransferase activity
GU243_12155	COG0789	Transcriptional regulator
GU243_12240	COG0494	nUDIX hydrolase
GU243_12255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GU243_12270	COG0395	ABC-type sugar transport system, permease component
GU243_12275	COG1349	DNA-binding transcription factor activity
GU243_12280	COG1609	Transcriptional regulator
GU243_12290	COG4209	transmembrane transport
GU243_12310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GU243_12340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GU243_12345	COG1408	metallophosphoesterase
GU243_12350	COG1132	(ABC) transporter
GU243_12355	COG1132	(ABC) transporter
GU243_12375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GU243_12380	COG0151	Belongs to the GarS family
GU243_12400	COG0546	phosphoglycolate phosphatase activity
GU243_12410	COG3387	PFAM Glycoside hydrolase 15-related
GU243_12430	COG0395	ABC-type sugar transport system, permease component
GU243_12435	COG1175	transmembrane transport
GU243_12450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GU243_12500	COG4948	Mandelate Racemase Muconate Lactonizing
GU243_12505	COG0395	ABC-type sugar transport system, permease component
GU243_12510	COG1175	transmembrane transport
GU243_12530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GU243_12535	COG0563	adenylate kinase activity
GU243_12570	COG0745	RESPONSE REGULATOR receiver
GU243_12585	COG2267	carboxylic ester hydrolase activity
GU243_12605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GU243_12650	COG0477	Major facilitator Superfamily
GU243_12690	COG1473	amidohydrolase
GU243_12695	COG0477	Major facilitator Superfamily
GU243_12745	COG0477	Major facilitator Superfamily
GU243_12750	COG0028	Belongs to the TPP enzyme family
GU243_12760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GU243_12765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GU243_12805	COG4106	trans-aconitate 2-methyltransferase activity
GU243_12810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GU243_12820	COG0251	oxidation-reduction process
GU243_12830	COG0477	Major facilitator Superfamily
GU243_12855	COG0277	FAD linked oxidase domain protein
GU243_12855	COG0277	FAD linked oxidase domain protein
GU243_12880	COG2188	Transcriptional regulator
GU243_12895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GU243_12900	COG3639	organic phosphonate transmembrane transporter activity
GU243_12910	COG2351	hydroxyisourate hydrolase activity
GU243_12915	COG2271	Major facilitator Superfamily
GU243_12920	COG1802	Transcriptional regulator
GU243_12930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GU243_12940	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GU243_12950	COG0656	L-ascorbic acid biosynthetic process
GU243_12960	COG0667	Aldo Keto reductase
GU243_12965	COG1301	dicarboxylic acid transport
GU243_12980	COG1953	Uracil, thiamine, allantoin
GU243_12985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GU243_12995	COG3608	succinylglutamate desuccinylase aspartoacylase
GU243_12995	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GU243_13000	COG2252	PERMEase
GU243_13005	COG0590	tRNA wobble adenosine to inosine editing
GU243_13015	COG3285	dna ligase
GU243_13015	COG1793	dna ligase
GU243_13030	COG2233	PERMEase
GU243_13035	COG1414	Transcriptional regulator
GU243_13055	COG3257	ureidoglycine aminohydrolase activity
GU243_13080	COG0656	L-ascorbic acid biosynthetic process
GU243_13090	COG3338	carbonate dehydratase activity
GU243_13095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GU243_13130	COG3622	Belongs to the hyi family
GU243_13135	COG2084	Dehydrogenase
GU243_13140	COG3960	tartronate-semialdehyde synthase activity
GU243_13145	COG1929	Belongs to the glycerate kinase type-1 family
GU243_13150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GU243_13190	COG1063	alcohol dehydrogenase
GU243_13195	COG0395	ABC-type sugar transport system, permease component
GU243_13255	COG1250	3-hydroxyacyl-CoA dehydrogenase
GU243_13255	COG1024	Enoyl-CoA hydratase
GU243_13260	COG1960	acyl-CoA dehydrogenase activity
GU243_13265	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_13270	COG0183	Belongs to the thiolase family
GU243_13275	COG1309	transcriptional regulator
GU243_13280	COG2197	response regulator
GU243_13285	COG0477	Major facilitator Superfamily
GU243_13300	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_13325	COG2271	Major facilitator Superfamily
GU243_13355	COG4948	Mandelate Racemase Muconate Lactonizing
GU243_13370	COG0179	Fumarylacetoacetate (FAA) hydrolase
GU243_13375	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_13395	COG1126	abc transporter atp-binding protein
GU243_13415	COG2610	gluconate transmembrane transporter activity
GU243_13420	COG0800	Aldolase
GU243_13425	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GU243_13440	COG1414	Transcriptional regulator
GU243_13455	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GU243_13460	COG0395	ABC-type sugar transport system, permease component
GU243_13475	COG1940	carbohydrate kinase activity
GU243_13505	COG1737	Transcriptional regulator
GU243_13515	COG1012	belongs to the aldehyde dehydrogenase family
GU243_13540	COG0402	S-adenosylhomocysteine deaminase activity
GU243_13555	COG0402	S-adenosylhomocysteine deaminase activity
GU243_13590	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_13595	COG0395	ABC-type sugar transport system, permease component
GU243_13600	COG1175	transmembrane transport
GU243_13605	COG2182	Extracellular solute-binding protein
GU243_13610	COG1414	Transcriptional regulator
GU243_13615	COG3458	cephalosporin-C deacetylase activity
GU243_13620	COG0477	Major facilitator Superfamily
GU243_13640	COG4336	lyase activity
GU243_13660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GU243_13685	COG0395	ABC-type sugar transport system, permease component
GU243_13690	COG1175	transmembrane transport
GU243_13705	COG0277	FAD linked oxidase domain protein
GU243_13710	COG2026	Addiction module toxin, RelE StbE family
GU243_13715	COG2161	toxin-antitoxin pair type II binding
GU243_13725	COG1653	transport
GU243_13730	COG1175	transmembrane transport
GU243_13740	COG0673	inositol 2-dehydrogenase activity
GU243_13770	COG1070	Carbohydrate kinase
GU243_13775	COG2115	Belongs to the xylose isomerase family
GU243_13780	COG0277	FAD linked oxidase domain protein
GU243_13790	COG2017	converts alpha-aldose to the beta-anomer
GU243_13810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GU243_13815	COG1012	belongs to the aldehyde dehydrogenase family
GU243_13825	COG4221	oxidoreductase activity
GU243_13840	COG0477	Major facilitator Superfamily
GU243_13845	COG1473	amidohydrolase
GU243_13855	COG0444	Belongs to the ABC transporter superfamily
GU243_13875	COG0477	Major facilitator Superfamily
GU243_13880	COG0477	Major facilitator Superfamily
GU243_13885	COG0583	DNA-binding transcription factor activity
GU243_13895	COG0028	Belongs to the TPP enzyme family
GU243_13900	COG1012	belongs to the aldehyde dehydrogenase family
GU243_13910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GU243_13920	COG0454	-acetyltransferase
GU243_14030	COG3265	gluconokinase activity
GU243_14035	COG1846	Transcriptional regulator
GU243_14055	COG0028	Belongs to the TPP enzyme family
GU243_14065	COG2066	Belongs to the glutaminase family
GU243_14080	COG0583	DNA-binding transcription factor activity
GU243_14090	COG4191	Histidine kinase
GU243_14145	COG0745	RESPONSE REGULATOR receiver
GU243_14155	COG1366	Belongs to the anti-sigma-factor antagonist family
GU243_14180	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GU243_14200	COG4829	muconolactone delta-isomerase
GU243_14205	COG2031	fatty acid transporter
GU243_14210	COG0583	DNA-binding transcription factor activity
GU243_14220	COG1595	DNA-templated transcription, initiation
GU243_14225	COG2329	Antibiotic biosynthesis monooxygenase
GU243_14265	COG3585	molybdate ion transport
GU243_14290	COG0135	phosphoribosylanthranilate isomerase activity
GU243_14305	COG1528	Iron-storage protein
GU243_14315	COG2076	Multidrug Resistance protein
GU243_14325	COG2855	membrane
GU243_14330	COG0280	phosphate acetyltransferase
GU243_14335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GU243_14340	COG0686	Belongs to the AlaDH PNT family
GU243_14345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GU243_14385	COG1113	amino acid transport
GU243_14390	COG1072	(Pantothenic acid kinase))
GU243_14395	COG0667	Aldo Keto reductase
GU243_14410	COG0500	methyltransferase
GU243_14420	COG2807	transmembrane transport
GU243_14430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GU243_14545	COG3387	PFAM Glycoside hydrolase 15-related
GU243_14570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GU243_14600	COG0363	glucosamine-6-phosphate deaminase activity
GU243_14610	COG1263	PTS System
GU243_14615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GU243_14620	COG2190	(PTS) system
GU243_14620	COG1263	PTS System
GU243_14620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GU243_14625	COG2188	Transcriptional regulator
GU243_14640	COG0402	S-adenosylhomocysteine deaminase activity
GU243_14645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GU243_14650	COG0747	negative chemotaxis
GU243_14655	COG0601	transmembrane transport
GU243_14660	COG0444	Belongs to the ABC transporter superfamily
GU243_14665	COG4608	Belongs to the ABC transporter superfamily
GU243_14695	COG0789	Transcriptional regulator
GU243_14700	COG0484	heat shock protein binding
GU243_14705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GU243_14710	COG0443	Heat shock 70 kDa protein
GU243_14755	COG1280	lysine exporter protein (LysE YggA)
GU243_14760	COG0385	Bile acid
GU243_14765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GU243_14770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GU243_14770	COG0512	Glutamine amidotransferase of anthranilate synthase
GU243_14775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GU243_14800	COG0183	Belongs to the thiolase family
GU243_14805	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_14845	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GU243_14850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GU243_14870	COG4721	ABC-type cobalt transport system, permease component
GU243_14875	COG4702	Belongs to the UPF0303 family
GU243_14885	COG1320	monovalent cation:proton antiporter activity
GU243_14890	COG2212	antiporter activity
GU243_14905	COG1006	Multisubunit Na H antiporter MnhC subunit
GU243_14910	COG2111	Na H antiporter
GU243_14910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GU243_14920	COG0569	domain protein
GU243_14920	COG2985	domain, Protein
GU243_14925	COG0475	glutathione-regulated potassium exporter activity
GU243_14935	COG0717	Belongs to the dCTP deaminase family
GU243_14970	COG0583	DNA-binding transcription factor activity
GU243_14980	COG0531	amino acid
GU243_14985	COG0583	DNA-binding transcription factor activity
GU243_14990	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GU243_14995	COG0679	Auxin Efflux Carrier
GU243_15005	COG3387	PFAM Glycoside hydrolase 15-related
GU243_15010	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GU243_15020	COG1175	transmembrane transport
GU243_15030	COG1609	Transcriptional regulator
GU243_15035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GU243_15055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GU243_15115	COG3336	cytochrome c oxidase
GU243_15120	COG0776	regulation of translation
GU243_15125	COG3328	transposase activity
GU243_15145	COG2226	methyltransferase
GU243_15170	COG4176	ABC-type proline glycine betaine transport system permease component
GU243_15175	COG0517	IMP dehydrogenase activity
GU243_15175	COG4175	Glycine betaine
GU243_15205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GU243_15225	COG1802	Transcriptional regulator
GU243_15230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GU243_15255	COG1760	l-serine dehydratase
GU243_15280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GU243_15290	COG1957	nucleoside hydrolase
GU243_15295	COG1609	Transcriptional regulator
GU243_15325	COG2814	Major facilitator Superfamily
GU243_15335	COG1070	Carbohydrate kinase
GU243_15340	COG0588	phosphoglycerate mutase activity
GU243_15350	COG1349	DNA-binding transcription factor activity
GU243_15355	COG4213	ABC transporter substrate-binding protein
GU243_15365	COG4214	carbohydrate transport
GU243_15375	COG0659	secondary active sulfate transmembrane transporter activity
GU243_15380	COG3706	GGDEF domain
GU243_15385	COG2197	response regulator
GU243_15390	COG4585	Histidine kinase
GU243_15400	COG1136	(ABC) transporter
GU243_15425	COG0698	ribose 5-phosphate isomerase
GU243_15430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GU243_15435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GU243_15445	COG2197	response regulator
GU243_15455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GU243_15550	COG3547	Transposase (IS116 IS110 IS902 family)
GU243_15575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GU243_15600	COG2814	Major facilitator Superfamily
GU243_15620	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GU243_15630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GU243_15635	COG0830	nickel cation binding
GU243_15640	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GU243_15645	COG0804	urea catabolic process
GU243_15650	COG0832	Belongs to the urease beta subunit family
GU243_15655	COG0831	urea catabolic process
GU243_15690	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GU243_15695	COG2186	Transcriptional regulator
GU243_15705	COG1129	ABC transporter
GU243_15710	COG4213	ABC transporter substrate-binding protein
GU243_15715	COG2017	converts alpha-aldose to the beta-anomer
GU243_15720	COG2160	L-arabinose isomerase activity
GU243_15735	COG1609	Transcriptional regulator
GU243_15755	COG0346	lactoylglutathione lyase activity
GU243_15795	COG1609	Transcriptional regulator
GU243_15825	COG1716	ATPase activity
GU243_15830	COG1716	ATPase activity
GU243_15845	COG0768	penicillin binding
GU243_15855	COG0515	serine threonine protein kinase
GU243_15865	COG3764	Sortase (surface protein transpeptidase)
GU243_15875	COG2818	Glycosylase
GU243_15880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GU243_15890	COG0705	Rhomboid family
GU243_15905	COG1215	transferase activity, transferring glycosyl groups
GU243_15925	COG3266	domain, Protein
GU243_15930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GU243_15935	COG0187	DNA topoisomerase II activity
GU243_15940	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GU243_15950	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GU243_15955	COG0592	DNA-directed DNA polymerase activity
GU243_15960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GU243_15965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GU243_15970	COG0594	ribonuclease P activity
GU243_15975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GU243_15980	COG0706	membrane insertase activity
GU243_15990	COG0357	Ribosomal RNA small subunit methyltransferase G
GU243_15995	COG1192	Involved in chromosome partitioning
GU243_16005	COG3118	belongs to the thioredoxin family
GU243_16010	COG0492	ferredoxin-NADP+ reductase activity
GU243_16030	COG0617	tRNA 3'-terminal CCA addition
GU243_16035	COG0406	alpha-ribazole phosphatase activity
GU243_16055	COG0768	penicillin binding
GU243_16060	COG0488	(ABC) transporter
GU243_16070	COG0738	Major facilitator superfamily
GU243_16090	COG4585	Histidine kinase
GU243_16095	COG2197	response regulator
GU243_16105	COG1362	aminopeptidase activity
GU243_16115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GU243_16125	COG0360	Binds together with S18 to 16S ribosomal RNA
GU243_16135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GU243_16140	COG0359	binds to the 23S rRNA
GU243_16150	COG2132	Multicopper oxidase
GU243_16200	COG0534	Mate efflux family protein
GU243_16245	COG1937	Protein conserved in bacteria
GU243_16300	COG1414	Transcriptional regulator
GU243_16305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GU243_16315	COG3485	protocatechuate 3,4-dioxygenase
GU243_16320	COG3485	protocatechuate 3,4-dioxygenase
GU243_16325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GU243_16335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GU243_16340	COG0183	Belongs to the thiolase family
GU243_16350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GU243_16355	COG1414	Transcriptional regulator
GU243_16405	COG1597	lipid kinase activity
GU243_16420	COG1435	thymidine kinase activity
GU243_16430	COG3842	ATPase activity
GU243_16435	COG1840	ABC-type Fe3 transport system, periplasmic component
GU243_16440	COG1607	acyl-coa hydrolase
GU243_16455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GU243_16465	COG1950	PFAM Membrane protein of
GU243_16470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GU243_16480	COG0022	dehydrogenase e1 component
GU243_16485	COG0508	dehydrogenase complex catalyzes the overall conversion of
GU243_16520	COG1309	transcriptional regulator
GU243_16545	COG0673	inositol 2-dehydrogenase activity
GU243_16555	COG0686	Belongs to the AlaDH PNT family
GU243_16575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GU243_16580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GU243_16595	COG0246	Mannitol dehydrogenase
GU243_16605	COG0477	Major facilitator Superfamily
GU243_16610	COG3135	benzoate transporter
GU243_16615	COG0477	Major facilitator Superfamily
GU243_16630	COG1309	transcriptional regulator
GU243_16635	COG0281	malic enzyme
GU243_16655	COG1280	lysine exporter protein (LysE YggA)
GU243_16660	COG1522	sequence-specific DNA binding
GU243_16670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GU243_16685	COG0477	Major facilitator Superfamily
GU243_16695	COG1960	acyl-CoA dehydrogenase activity
GU243_16705	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_16715	COG2814	Major facilitator Superfamily
GU243_16725	COG1802	Transcriptional regulator
GU243_16730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GU243_16735	COG0183	Belongs to the thiolase family
GU243_16755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GU243_16775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GU243_16800	COG2186	Transcriptional regulator
GU243_16810	COG1301	dicarboxylic acid transport
GU243_16815	COG1027	Aspartate ammonia-lyase
GU243_16825	COG0586	Pfam SNARE associated Golgi protein
GU243_16865	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GU243_16880	COG0586	Pfam SNARE associated Golgi protein
GU243_16885	COG0671	phosphoesterase, PA-phosphatase related
GU243_16905	COG0702	epimerase
GU243_16910	COG0667	Aldo Keto reductase
GU243_16915	COG0667	Aldo Keto reductase
GU243_16925	COG3012	SEC-C Motif Domain Protein
GU243_16975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GU243_16980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GU243_16985	COG1120	ATPase activity
GU243_17010	COG1177	transmembrane transport
GU243_17015	COG3842	ATPase activity
GU243_17045	COG1017	nitric oxide dioxygenase activity
GU243_17045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GU243_17050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GU243_17055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GU243_17060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GU243_17090	COG2801	Transposase and inactivated derivatives
GU243_17220	COG0363	glucosamine-6-phosphate deaminase activity
GU243_17225	COG2226	methyltransferase
GU243_17240	COG3511	phospholipase C
GU243_17260	COG3328	transposase activity
GU243_17270	COG1595	DNA-templated transcription, initiation
GU243_17305	COG1228	amidohydrolase
GU243_17310	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GU243_17315	COG1940	carbohydrate kinase activity
GU243_17320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GU243_17325	COG4608	Belongs to the ABC transporter superfamily
GU243_17330	COG0444	Belongs to the ABC transporter superfamily
GU243_17340	COG0747	negative chemotaxis
GU243_17360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GU243_17365	COG0561	phosphatase activity
GU243_17375	COG0584	glycerophosphoryl diester phosphodiesterase
GU243_17380	COG2200	EAL domain
GU243_17390	COG2205	protein histidine kinase activity
GU243_17405	COG1929	Belongs to the glycerate kinase type-1 family
GU243_17430	COG2755	lipolytic protein G-D-S-L family
GU243_17435	COG2233	PERMEase
GU243_17440	COG0778	Nitroreductase
GU243_17485	COG1597	lipid kinase activity
GU243_17490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GU243_17500	COG0561	phosphatase activity
GU243_17510	COG0673	inositol 2-dehydrogenase activity
GU243_17525	COG1653	transport
GU243_17530	COG1609	Transcriptional regulator
GU243_17540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GU243_17570	COG0037	tRNA processing
GU243_17590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GU243_17595	COG0302	gtp cyclohydrolase
GU243_17600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GU243_17605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GU243_17635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GU243_17665	COG1309	transcriptional regulator
GU243_17670	COG0640	Transcriptional regulator
GU243_17695	COG2814	Major facilitator Superfamily
GU243_17715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GU243_17760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GU243_17770	COG1461	Dihydroxyacetone kinase
GU243_17815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GU243_17835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GU243_17855	COG0583	DNA-binding transcription factor activity
GU243_17865	COG3842	ATPase activity
GU243_17870	COG1176	ABC-type spermidine putrescine transport system, permease component I
GU243_17875	COG1177	transmembrane transport
GU243_17880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GU243_17885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GU243_17895	COG0477	Major facilitator Superfamily
GU243_17900	COG4221	oxidoreductase activity
GU243_17905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GU243_17915	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_17920	COG1063	alcohol dehydrogenase
GU243_17950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GU243_17965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GU243_17970	COG0306	phosphate transporter
GU243_18000	COG1473	amidohydrolase
GU243_18035	COG2890	protein-(glutamine-N5) methyltransferase activity
GU243_18055	COG2261	transglycosylase associated protein
GU243_18060	COG0656	L-ascorbic acid biosynthetic process
GU243_18080	COG0667	Aldo Keto reductase
GU243_18085	COG0656	L-ascorbic acid biosynthetic process
GU243_18100	COG3360	Dodecin
GU243_18105	COG2186	Transcriptional regulator
GU243_18115	COG2084	Dehydrogenase
GU243_18120	COG2610	gluconate transmembrane transporter activity
GU243_18145	COG0076	glutamate decarboxylase activity
GU243_18150	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GU243_18165	COG4941	Belongs to the sigma-70 factor family
GU243_18170	COG3795	YCII-related domain
GU243_18175	COG0300	oxidoreductase activity
GU243_18185	COG0477	Major facilitator Superfamily
GU243_18205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GU243_18240	COG1349	DNA-binding transcription factor activity
GU243_18275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GU243_18330	COG4122	O-methyltransferase activity
GU243_18335	COG0783	Belongs to the Dps family
GU243_18355	COG1295	ribonuclease BN
GU243_18395	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_18405	COG1733	regulation of RNA biosynthetic process
GU243_18410	COG0702	epimerase
GU243_18415	COG1280	lysine exporter protein (LysE YggA)
GU243_18430	COG1476	TRANSCRIPTIONal
GU243_18435	COG0604	alcohol dehydrogenase
GU243_18445	COG2318	DinB family
GU243_18460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GU243_18480	COG0589	response to stress
GU243_18500	COG3290	protein histidine kinase activity
GU243_18510	COG0010	Belongs to the arginase family
GU243_18515	COG2252	PERMEase
GU243_18520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GU243_18580	COG0697	spore germination
GU243_18615	COG0601	transmembrane transport
GU243_18620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GU243_18625	COG0444	Belongs to the ABC transporter superfamily
GU243_18650	COG1621	beta-fructofuranosidase activity
GU243_18685	COG0366	Alpha amylase catalytic
GU243_18710	COG1609	Transcriptional regulator
GU243_18730	COG1024	Enoyl-CoA hydratase
GU243_18740	COG1024	Enoyl-CoA hydratase
GU243_18765	COG0765	amino acid transport
GU243_18770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GU243_18800	COG1960	acyl-CoA dehydrogenase activity
GU243_18805	COG1278	Cold shock
GU243_18810	COG2197	response regulator
GU243_18815	COG4585	Histidine kinase
GU243_18870	COG1609	Transcriptional regulator
GU243_18880	COG0673	inositol 2-dehydrogenase activity
GU243_18910	COG0673	inositol 2-dehydrogenase activity
GU243_18915	COG1609	Transcriptional regulator
GU243_18920	COG1904	glucuronate isomerase
GU243_18925	COG0246	Mannitol dehydrogenase
GU243_18935	COG4948	Mandelate Racemase Muconate Lactonizing
GU243_18950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GU243_18965	COG0357	Ribosomal RNA small subunit methyltransferase G
GU243_18965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GU243_18995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GU243_19015	COG1832	CoA-binding protein
GU243_19030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GU243_19035	COG1832	CoA-binding protein
GU243_19045	COG2315	Protein conserved in bacteria
GU243_19070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GU243_19075	COG0047	phosphoribosylformylglycinamidine synthase activity
GU243_19125	COG1846	Transcriptional regulator
GU243_19145	COG4555	ABC transporter
GU243_19160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GU243_19175	COG4115	mRNA cleavage
GU243_19180	COG2161	toxin-antitoxin pair type II binding
GU243_19200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GU243_19200	COG3323	Protein of unknown function (DUF1653)
GU243_19215	COG0739	heme binding
GU243_19215	COG1196	nuclear chromosome segregation
GU243_19215	COG0741	lytic transglycosylase activity
GU243_19220	COG0386	Belongs to the glutathione peroxidase family
GU243_19230	COG0438	transferase activity, transferring glycosyl groups
GU243_19260	COG1309	transcriptional regulator
GU243_19280	COG0673	inositol 2-dehydrogenase activity
GU243_19285	COG0673	inositol 2-dehydrogenase activity
GU243_19295	COG0395	ABC-type sugar transport system, permease component
GU243_19315	COG0673	inositol 2-dehydrogenase activity
GU243_19320	COG1940	carbohydrate kinase activity
GU243_19325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GU243_19330	COG2807	transmembrane transport
GU243_19355	COG2205	protein histidine kinase activity
GU243_19360	COG0745	RESPONSE REGULATOR receiver
GU243_19365	COG0477	Major facilitator Superfamily
GU243_19370	COG0028	Belongs to the TPP enzyme family
GU243_19380	COG0351	phosphomethylpyrimidine kinase
GU243_19410	COG0343	queuine tRNA-ribosyltransferase activity
GU243_19440	COG3842	ATPase activity
GU243_19455	COG0390	transport system, permease component
GU243_19470	COG1960	acyl-CoA dehydrogenase activity
GU243_19480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GU243_19530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GU243_19550	COG0375	protein maturation
GU243_19555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GU243_19605	COG0564	pseudouridine synthase activity
GU243_19630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GU243_19640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GU243_19645	COG1201	RNA secondary structure unwinding
GU243_19650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GU243_19650	COG0723	plastoquinol--plastocyanin reductase activity
GU243_19655	COG1609	Transcriptional regulator
GU243_19660	COG4209	transmembrane transport
GU243_19665	COG0395	ABC-type sugar transport system, permease component
GU243_19670	COG1653	transport
GU243_19675	COG1621	beta-fructofuranosidase activity
GU243_19680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GU243_19705	COG2070	2-Nitropropane dioxygenase
GU243_19740	COG0438	transferase activity, transferring glycosyl groups
GU243_19755	COG0671	phosphoesterase, PA-phosphatase related
GU243_19760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GU243_19780	COG2205	protein histidine kinase activity
GU243_19785	COG0745	RESPONSE REGULATOR receiver
GU243_19795	COG2062	phosphohistidine phosphatase, SixA
GU243_19815	COG1309	transcriptional regulator
GU243_19820	COG1511	domain protein
GU243_19830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GU243_19840	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GU243_19845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GU243_19845	COG1017	nitric oxide dioxygenase activity
GU243_19860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GU243_19865	COG0514	ATP-dependent DNA helicase (RecQ)
GU243_19905	COG0604	alcohol dehydrogenase
GU243_19915	COG1136	(ABC) transporter
GU243_19915	COG0577	efflux transmembrane transporter activity
GU243_19930	COG1966	Carbon starvation protein
GU243_19975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GU243_19980	COG1263	PTS System
GU243_19985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GU243_19990	COG2190	(PTS) system
GU243_19990	COG1263	PTS System
GU243_19990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GU243_19995	COG2188	Transcriptional regulator
GU243_20010	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GU243_20025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GU243_20030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GU243_20050	COG0588	phosphoglycerate mutase activity
GU243_20080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GU243_20085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GU243_20090	COG0215	cysteine-tRNA ligase activity
GU243_20095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GU243_20120	COG0366	Alpha amylase catalytic
GU243_20130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GU243_20155	COG1609	Transcriptional regulator
GU243_20160	COG0366	Alpha amylase catalytic
GU243_20165	COG0277	FAD linked oxidase domain protein
GU243_20230	COG2957	Belongs to the agmatine deiminase family
GU243_20235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GU243_20240	COG0783	Belongs to the Dps family
GU243_20255	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GU243_20255	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GU243_20295	COG1278	Cold shock
GU243_20305	COG0459	protein refolding
GU243_20310	COG0328	RNA-DNA hybrid ribonuclease activity
GU243_20320	COG2205	protein histidine kinase activity
GU243_20325	COG0745	RESPONSE REGULATOR receiver
GU243_20345	COG1278	Cold shock
GU243_20370	COG0739	heme binding
GU243_20400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GU243_20415	COG2267	carboxylic ester hydrolase activity
GU243_20450	COG1132	(ABC) transporter
GU243_20455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GU243_20480	COG0483	inositol monophosphate 1-phosphatase activity
GU243_20500	COG0045	succinate-CoA ligase (ADP-forming) activity
GU243_20530	COG0640	Transcriptional regulator
GU243_20535	COG1942	4-Oxalocrotonate Tautomerase
GU243_20540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GU243_20550	COG3962	Belongs to the TPP enzyme family
GU243_20565	COG0673	inositol 2-dehydrogenase activity
GU243_20570	COG1082	Xylose isomerase domain protein TIM barrel
GU243_20575	COG2814	Major facilitator Superfamily
GU243_20605	COG1172	Belongs to the binding-protein-dependent transport system permease family
GU243_20615	COG0673	inositol 2-dehydrogenase activity
GU243_20620	COG0673	inositol 2-dehydrogenase activity
GU243_20625	COG0673	inositol 2-dehydrogenase activity
GU243_20635	COG0673	inositol 2-dehydrogenase activity
GU243_20650	COG3718	enzyme involved in inositol metabolism
GU243_20680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GU243_20685	COG1396	sequence-specific DNA binding
GU243_20695	COG0028	Belongs to the TPP enzyme family
GU243_20730	COG1401	restriction endodeoxyribonuclease activity
GU243_20740	COG5002	protein histidine kinase activity
GU243_20745	COG0745	RESPONSE REGULATOR receiver
GU243_20775	COG1902	pentaerythritol trinitrate reductase activity
GU243_20805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GU243_20820	COG3583	domain protein
GU243_20830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GU243_20845	COG1254	Belongs to the acylphosphatase family
GU243_20850	COG2814	Major facilitator Superfamily
GU243_20880	COG1063	alcohol dehydrogenase
GU243_20910	COG0640	Transcriptional regulator
GU243_20975	COG0726	polysaccharide deacetylase
GU243_20985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GU243_21045	COG1073	alpha beta
GU243_21055	COG0667	Aldo Keto reductase
GU243_21135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GU243_21150	COG0477	Major facilitator Superfamily
GU243_21160	COG5002	protein histidine kinase activity
GU243_21200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GU243_21210	COG0477	Major facilitator Superfamily
GU243_21230	COG3795	YCII-related domain
GU243_21290	COG0667	Aldo Keto reductase
GU243_21300	COG0076	glutamate decarboxylase activity
GU243_21335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GU243_21340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GU243_21345	COG0765	amino acid transport
GU243_21370	COG1597	lipid kinase activity
GU243_21375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GU243_21390	COG0028	Belongs to the TPP enzyme family
GU243_21400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GU243_21405	COG1113	amino acid transport
GU243_21490	COG1063	alcohol dehydrogenase
GU243_21525	COG2337	Toxic component of a toxin-antitoxin (TA) module
GU243_21585	COG0633	Ferredoxin
GU243_21585	COG0543	2 iron, 2 sulfur cluster binding
GU243_21590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GU243_21595	COG0456	acetyltransferase
GU243_21600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GU243_21615	COG1404	Belongs to the peptidase S8 family
GU243_21620	COG2186	Transcriptional regulator
GU243_21650	COG3540	Alkaline phosphatase
GU243_21680	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_21775	COG2337	Toxic component of a toxin-antitoxin (TA) module
GU243_21785	COG3550	peptidyl-serine autophosphorylation
GU243_21835	COG4942	peptidase
GU243_21870	COG0673	inositol 2-dehydrogenase activity
GU243_21935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GU243_21940	COG0667	Aldo Keto reductase
GU243_21945	COG1278	Cold shock
GU243_21960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GU243_21970	COG3265	gluconokinase activity
GU243_21975	COG2610	gluconate transmembrane transporter activity
GU243_22000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GU243_22025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GU243_22025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GU243_22030	COG5001	Diguanylate cyclase
GU243_22030	COG3300	MHYT domain
GU243_22040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GU243_22040	COG0438	transferase activity, transferring glycosyl groups
GU243_22065	COG1012	belongs to the aldehyde dehydrogenase family
GU243_22070	COG1028	Short-chain dehydrogenase reductase Sdr
GU243_22080	COG1024	Enoyl-CoA hydratase
GU243_22085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GU243_22090	COG0446	pyridine nucleotide-disulphide oxidoreductase
GU243_22095	COG0477	Major facilitator Superfamily
GU243_22100	COG1396	sequence-specific DNA binding
GU243_22130	COG0477	Major facilitator Superfamily
GU243_22135	COG0138	bifunctional purine biosynthesis protein purh
GU243_22150	COG2838	Isocitrate dehydrogenase
GU243_22160	COG0515	serine threonine protein kinase
GU243_22175	COG0673	inositol 2-dehydrogenase activity
GU243_22180	COG1136	(ABC) transporter
GU243_22185	COG1136	(ABC) transporter
GU243_22185	COG0577	efflux transmembrane transporter activity
GU243_22195	COG1172	Belongs to the binding-protein-dependent transport system permease family
GU243_22210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GU243_22235	COG2226	methyltransferase
GU243_22250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GU243_22265	COG0180	Tryptophanyl-tRNA synthetase
GU243_22285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GU243_22300	COG2009	succinate dehydrogenase
GU243_22310	COG1473	amidohydrolase
GU243_22310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GU243_22315	COG1846	Transcriptional regulator
GU243_22320	COG1764	response to oxidative stress
GU243_22325	COG2130	NADP-dependent
GU243_22360	COG0586	Pfam SNARE associated Golgi protein
GU243_22370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GU243_22375	COG3956	TIGRFAM MazG family protein
GU243_22380	COG0148	phosphopyruvate hydratase activity
GU243_22400	COG1404	Belongs to the peptidase S8 family
GU243_22405	COG1252	NADH dehydrogenase
GU243_22440	COG0559	Belongs to the binding-protein-dependent transport system permease family
GU243_22450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GU243_22460	COG2017	converts alpha-aldose to the beta-anomer
GU243_22470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GU243_22480	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GU243_22490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GU243_22505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GU243_22510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GU243_22540	COG0114	fumarate hydratase activity
GU243_22545	COG0288	reversible hydration of carbon dioxide
GU243_22580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GU243_22585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GU243_22630	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GU243_22690	COG0714	Associated with various cellular activities
GU243_22695	COG0084	hydrolase, TatD family'
GU243_22700	COG3583	domain protein
GU243_22705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GU243_22715	COG0488	(ABC) transporter
GU243_22730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GU243_22740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GU243_22745	COG0193	aminoacyl-tRNA hydrolase activity
GU243_22765	COG0822	iron-sulfur transferase activity
GU243_22770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GU243_22805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GU243_22810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GU243_22825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GU243_22835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GU243_22840	COG1959	2 iron, 2 sulfur cluster binding
GU243_22870	COG0243	molybdopterin cofactor binding
GU243_22875	COG2223	nitrite transmembrane transporter activity
GU243_22880	COG0477	Major facilitator Superfamily
GU243_22895	COG4770	biotin carboxylase activity
GU243_22900	COG0424	maF-like protein
GU243_22935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GU243_22945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GU243_22945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GU243_22965	COG0714	Associated with various cellular activities
GU243_22985	COG0631	protein serine/threonine phosphatase activity
GU243_23005	COG1674	ftsk spoiiie
GU243_23020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GU243_23025	COG0483	inositol monophosphate 1-phosphatase activity
GU243_23035	COG0251	oxidation-reduction process
GU243_23040	COG4565	transcriptional regulatory protein
GU243_23050	COG2851	Citrate transporter
GU243_23055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GU243_23060	COG0154	amidase activity
GU243_23065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GU243_23075	COG0583	DNA-binding transcription factor activity
GU243_23080	COG1063	alcohol dehydrogenase
GU243_23085	COG0156	8-amino-7-oxononanoate synthase activity
GU243_23120	COG2873	o-acetylhomoserine
GU243_23125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GU243_23170	COG0400	carboxylic ester hydrolase activity
GU243_23190	COG0423	glycine-tRNA ligase activity
GU243_23300	COG1192	Involved in chromosome partitioning
GU243_23335	COG1475	DNA binding
GU243_23390	COG0629	single-stranded DNA binding
GU243_23405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GU243_23410	COG1609	Transcriptional regulator
GU243_23425	COG0251	oxidation-reduction process
GU243_23430	COG0640	Transcriptional regulator
GU243_23475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GU243_23680	COG0741	lytic transglycosylase activity
GU243_23745	COG1793	dna ligase
GU243_23810	COG1960	acyl-CoA dehydrogenase activity
GU243_23820	COG1024	Enoyl-CoA hydratase
GU243_23830	COG2814	Major facilitator Superfamily
GU243_23835	COG0318	PFAM AMP-dependent synthetase and ligase
GU243_23845	COG1024	Enoyl-CoA hydratase
GU243_23845	COG1250	3-hydroxyacyl-CoA dehydrogenase
GU243_23855	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GU243_23870	COG0444	Belongs to the ABC transporter superfamily
GU243_23880	COG4166	transmembrane transport
GU243_23900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GU243_23955	COG1192	Involved in chromosome partitioning
GU243_24030	COG1063	alcohol dehydrogenase
GU243_24035	COG0477	Major facilitator Superfamily
GU243_24050	COG2814	Major facilitator Superfamily
GU243_24090	COG2188	Transcriptional regulator
GU243_24095	COG3718	enzyme involved in inositol metabolism
GU243_24100	COG0673	inositol 2-dehydrogenase activity
GU243_24120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GU243_24135	COG4644	lycopene metabolic process
GU243_24210	COG1475	DNA binding