locus-tag class description Daes_0001 ENOG4107QJE Chromosome Partitioning Protein Daes_0003 ENOG4105FA0 parb-like partition protein Daes_0004 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Daes_0005 ENOG4105CTQ phosphohexokinase Daes_0008 ENOG4105F2W methyltransferase Daes_0011 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Daes_0012 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Daes_0013 ENOG4105C8M UPF0272 protein Daes_0015 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_0023 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_0026 ENOG4105BZU Histidine kinase Daes_0027 ENOG4105CPI Metal Dependent Phosphohydrolase Daes_0028 ENOG4108SHN Glycosyl transferase, family 2 Daes_0029 ENOG4105BZU Histidine kinase Daes_0031 ENOG4105BZU Histidine kinase Daes_0032 ENOG4105C0A alcohol dehydrogenase Daes_0033 ENOG4105BZU Histidine kinase Daes_0034 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Daes_0036 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_0038 ENOG4105D58 Diguanylate phosphodiesterase Daes_0039 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Daes_0043 ENOG4107RE7 phosphate butyryltransferase Daes_0044 ENOG4105CKM Branched-chain carboxylic acid kinase Daes_0045 ENOG4105BZU Histidine kinase Daes_0050 ENOG4105HA9 of methanol dehydrogenase type Daes_0051 ENOG4108V0P LemA family Daes_0054 ENOG4108ZUB Lysine exporter protein (Lyse ygga) Daes_0055 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Daes_0056 ENOG4107U9B transcriptional regulator Daes_0058 ENOG4105C9Q fumarate hydratase class II Daes_0062 ENOG4108UYB regulatoR Daes_0064 ENOG4105XJC Two component transcriptional regulator (Winged helix family Daes_0065 ENOG4105BZU Histidine kinase Daes_0067 ENOG4105CHH sulfate transporter Daes_0068 ENOG41062JF Transcriptional regulator Daes_0073 ENOG4105CMR udp-glucose 4-epimerase Daes_0077 ENOG4108IUS Transketolase Daes_0080 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Daes_0085 ENOG4105W3S hemerythrin-like, metal-binding protein Daes_0089 ENOG4105K64 Glycosyl transferase, family 2 Daes_0090 ENOG4108SHN Glycosyl transferase, family 2 Daes_0098 ENOG4105F0R Cytidylyltransferase Daes_0100 ENOG4105K64 Glycosyl transferase, family 2 Daes_0101 ENOG4105CNV Aldolase Daes_0102 ENOG4108JQ1 Dehydrogenase Daes_0103 ENOG4105C1B dTDP-glucose 4-6-dehydratase Daes_0105 ENOG4105F0R Cytidylyltransferase Daes_0110 ENOG4105BZU Histidine kinase Daes_0113 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0114 ENOG4105BZU Histidine kinase Daes_0116 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_0117 ENOG4105BZU Histidine kinase Daes_0118 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Daes_0119 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Daes_0123 ENOG4105HF0 Membrane Daes_0127 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Daes_0130 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Daes_0131 ENOG4105CJR Integral membrane protein (MviN Daes_0132 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Daes_0140 ENOG4105CRP Part of the ABC transporter FtsEX involved in Daes_0141 ENOG4105CAK Cell division ATP-binding protein ftsE Daes_0142 ENOG4105BZM domain protein Daes_0145 ENOG4105ES5 Histidine kinase Daes_0147 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_0148 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Daes_0149 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Daes_0150 ENOG4105K63 Thioredoxin Daes_0154 ENOG4105W87 Cbs domain Daes_0160 ENOG4107WHI formate dehydrogenase, beta subunit Daes_0165 ENOG4105CVM Molybdenum cofactor synthesis domain protein Daes_0166 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Daes_0167 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Daes_0168 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Daes_0169 ENOG4107XR4 alpha beta Daes_0175 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Daes_0176 ENOG4105C03 ribonuclease Daes_0177 ENOG4105WPN DNA integration recombination invertion protein Daes_0181 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Daes_0185 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_0186 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Daes_0189 ENOG4107QKV phosphomannomutase Daes_0190 ENOG4107QJR hflk protein Daes_0191 ENOG4105EPW hflc protein Daes_0193 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Daes_0199 ENOG4105CPK Glycosyl transferase (Group 1 Daes_0200 ENOG4105CD5 CoA-binding domain protein Daes_0202 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Daes_0203 ENOG4108V3W Chemotaxis protein, CheW Daes_0205 ENOG4105CI2 imidazolone-5-propionate hydrolase Daes_0206 ENOG4105D58 Diguanylate phosphodiesterase Daes_0207 ENOG41061GT Aldolase Daes_0218 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0219 ENOG4105DHT Metal Dependent Phosphohydrolase Daes_0221 ENOG4105D9P serine threonine protein kinase Daes_0223 ENOG4107X35 defense response to bacterium Daes_0224 ENOG4105F8V Hydrolase, tatD family Daes_0229 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Daes_0230 ENOG4105C9U ATP-dependent DNA helicase RecQ Daes_0234 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Daes_0235 ENOG4105C9M aspartyl-trna synthetase Daes_0236 ENOG4105CUT histidyl-tRNA synthetase Daes_0237 ENOG4108JB9 formate dehydrogenase Daes_0239 ENOG41083U2 ABC transporter, permease Daes_0240 ENOG4108JQ9 ABC transporter Daes_0241 ENOG4105DIH basic membrane Daes_0242 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Daes_0245 ENOG4105DGU Histone deacetylase Daes_0253 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Daes_0255 ENOG4105DFA alanine racemase domain protein Daes_0256 ENOG4105E14 MotA TolQ exbB proton channel Daes_0257 ENOG4106VK6 Flagellar motor protein Daes_0258 ENOG4105ER2 Ompa motb domain protein Daes_0260 ENOG4105DD5 Flagellar motor switch protein Daes_0262 ENOG4105CN7 Flagellar biosynthetic protein FliP Daes_0263 ENOG4105VS8 Flagellar biosynthetic protein fliq Daes_0264 ENOG4105DAN ATP-dependent protease Daes_0266 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Daes_0269 ENOG410814Y Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) Daes_0270 ENOG4107SGM protein serine threonine phosphatase Daes_0277 ENOG4105C75 arginyL-tRNA synthetase Daes_0281 ENOG4107SQD Transcriptional regulator, GntR family Daes_0284 ENOG4107QP8 phosphohexose isomerase Daes_0285 ENOG4105BZU Histidine kinase Daes_0295 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Daes_0296 ENOG4107QW8 radical SAM domain protein Daes_0298 ENOG4108IJ0 Aspartate ammonia-lyase Daes_0302 ENOG4107QHI -hydrogenase Daes_0303 ENOG41075H3 AraC family transcriptional regulator Daes_0304 ENOG4108PCN EamA-like transporter family Daes_0305 ENOG4108Q5Y Membrane Daes_0310 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Daes_0311 ENOG4107T8Q Glycosyl transferase (Group 1 Daes_0312 ENOG4105EGD dinuclear metal center protein, YbgI family Daes_0314 ENOG4108EM8 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity) Daes_0316 ENOG4105C8N cysteinyl-tRNA synthetase Daes_0332 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Daes_0334 ENOG410631K Membrane Daes_0343 ENOG4105BZU Histidine kinase Daes_0344 ENOG4105BZU Histidine kinase Daes_0349 ENOG4107Y03 Nitroreductase Daes_0352 ENOG4107FQX Alpha-acetolactate decarboxylase Daes_0353 ENOG4108KMV Glycosyl transferase (Group 1 Daes_0356 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0357 ENOG4105BZE flagellar hook protein, FlgE Daes_0361 ENOG4105D7X high-affinity nickel-transporter Daes_0365 ENOG4108IAB Phoh family Daes_0366 ENOG4105CEV competence damage-inducible protein Daes_0368 ENOG4107SFQ iron-sulfur binding Daes_0373 ENOG4105BZU Histidine kinase Daes_0376 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_0377 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Daes_0378 ENOG4105KT5 UmuD protein Daes_0381 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Daes_0382 ENOG4105C4M (Ubiquinol oxidase) subunit I Daes_0383 ENOG4105CTQ phosphohexokinase Daes_0388 ENOG4105DIN metallophosphoesterase Daes_0389 ENOG4105D0M Protease HtpX homolog Daes_0390 ENOG4105C0H protease Daes_0405 ENOG4108J1Q Daes_0446 ENOG4105ED4 portal protein Daes_0456 ENOG4105KSC Transcriptional regulator, TraR DksA family Daes_0463 ENOG4105VDM plasmid maintenance system antidote protein, xre family Daes_0486 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Daes_0491 ENOG4107R3N Filamentation induced by cAMP protein fic Daes_0499 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0500 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Daes_0501 ENOG4107R7Y intracellular protease Pfpi family Daes_0502 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Daes_0503 ENOG41082YX Transcriptional regulator, arsr family Daes_0511 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Daes_0513 ENOG4108ESY Metal dependent phosphohydrolase Daes_0515 ENOG4105ECQ AraC Family Transcriptional Regulator Daes_0516 ENOG4105BZU Histidine kinase Daes_0520 ENOG4108TVJ Nitroreductase Daes_0521 ENOG4105KVH Transcriptional regulator Daes_0522 ENOG4105BZU Histidine kinase Daes_0524 ENOG4105BZU Histidine kinase Daes_0528 ENOG41080XS Cobyrinic acid ac-diamide synthase Daes_0529 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit Daes_0531 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Daes_0532 ENOG4105EE5 Membrane protein terC Daes_0534 ENOG41086D8 Transcriptional regulator Daes_0538 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_0542 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Daes_0544 ENOG4105CEY Amp-dependent synthetase and ligase Daes_0547 ENOG4105D5T phosphonate abc transporter Daes_0549 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_0551 ENOG4105BZU Histidine kinase Daes_0552 ENOG4105CPK Glycosyl transferase (Group 1 Daes_0554 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Daes_0557 ENOG4105WN5 stage II sporulation protein Daes_0568 ENOG4105D05 Receptor Daes_0576 ENOG4109015 Biopolymer transport protein exbD tolR Daes_0583 ENOG4105D05 Receptor Daes_0585 ENOG4105BZ1 (ABC) transporter Daes_0586 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Daes_0592 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Daes_0593 ENOG4107QW8 radical SAM domain protein Daes_0595 ENOG4108IJ0 Aspartate ammonia-lyase Daes_0599 ENOG4107QHI -hydrogenase Daes_0600 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Daes_0601 ENOG4105DVH amino acid Daes_0602 ENOG4105DZ2 Transcriptional regulator Daes_0605 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_0609 ENOG4105BZU Histidine kinase Daes_0610 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Daes_0612 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Daes_0614 ENOG4105C0B DNA polymerase III (alpha subunit) Daes_0615 ENOG4105C8P )-transporter Daes_0616 ENOG4105BZU Histidine kinase Daes_0624 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Daes_0625 ENOG4105BZU Histidine kinase Daes_0629 ENOG4105CKT filamentous hemagglutinin Daes_0630 ENOG4105D5K Hemolysin activator protein Daes_0631 ENOG4107ZHV Transcriptional regulator Daes_0635 ENOG4105CH2 amidohydrolase Daes_0636 ENOG4105EJQ L-serine dehydratase Daes_0638 ENOG4108IJ9 (ABC) transporter Daes_0639 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Daes_0640 ENOG4105DRS transport system, permease Daes_0641 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Daes_0642 ENOG4105D4U had-superfamily hydrolase, subfamily iia Daes_0647 ENOG4107U4H Methyl-accepting chemotaxis Daes_0654 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Daes_0655 ENOG4108YZA Nitrogen regulatory protein pii Daes_0656 ENOG4105BZU Histidine kinase Daes_0658 ENOG4105EAC phosphoserine phosphatase Daes_0661 ENOG4105D7N magnesium and cobalt transport protein CorA Daes_0663 ENOG410829K Lysine exporter protein (Lyse ygga) Daes_0664 ENOG4105C02 permease Daes_0665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Daes_0666 ENOG4105DY0 carbon monoxide dehydrogenase operon C protein Daes_0669 ENOG4105CYC Transferase Daes_0674 ENOG4107U32 Beta-lactamase domain protein Daes_0675 ENOG4105D9N nucleoside Daes_0683 ENOG4106V2I dimethylaminohydrolase Daes_0687 ENOG4105CHM Aminotransferase Daes_0688 ENOG4105D07 Signal peptide peptidase, SppA Daes_0689 ENOG410857E Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Daes_0690 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase Daes_0691 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) Daes_0698 ENOG4108YRB methyltransferase Daes_0700 ENOG4105CAQ asparagine synthetase Daes_0701 ENOG4107QVI Methyltransferase, type 11 Daes_0703 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Daes_0706 ENOG4105UEI Transcriptional Regulator AraC Family Daes_0707 ENOG4105BZ1 (ABC) transporter Daes_0709 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Daes_0713 ENOG4108I69 Glycosyl transferases group 1 Daes_0715 ENOG4105CAQ asparagine synthetase Daes_0717 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Daes_0720 ENOG4107TH8 cina domain protein Daes_0723 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Daes_0725 ENOG4105CY3 ABC transporter, permease Daes_0732 ENOG4105BZU Histidine kinase Daes_0734 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Daes_0735 ENOG4105DEU major facilitator superfamily Daes_0736 ENOG4105NBF ammecr1 domain protein Daes_0737 ENOG4105CPI Metal Dependent Phosphohydrolase Daes_0744 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Daes_0747 ENOG4108V3E phosphoribosylglycinamide formyltransferase Daes_0748 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Daes_0749 ENOG4105CGD Nad-dependent epimerase dehydratase Daes_0751 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Daes_0753 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Daes_0754 ENOG4108P62 biosynthesis protein (CbiG) Daes_0755 ENOG4105E4R Precorrin-3B C17-methyltransferase Daes_0762 ENOG4105K5M 30s ribosomal protein S16 Daes_0763 ENOG4105VB6 UPF0109 protein Daes_0764 ENOG41082N4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Daes_0765 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Daes_0766 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Daes_0770 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Daes_0771 ENOG4105VKD bioY protein Daes_0773 ENOG41080Z8 PHOSPHOCARRIER protein Daes_0774 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Daes_0775 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Daes_0777 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_0782 ENOG4105CVN desaturase Daes_0784 ENOG41086B8 CoB-CoM heterodisulfide reductase Daes_0786 ENOG4107QQM Cysteine-rich domain Daes_0788 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit Daes_0789 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Daes_0791 ENOG4105CQB FAD linked oxidase domain protein Daes_0794 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Daes_0801 ENOG4105EAH synthase Daes_0802 ENOG4107QIK phosphoribosylformylglycinamidine synthase Daes_0804 ENOG4107U4H Methyl-accepting chemotaxis Daes_0806 ENOG4108RAC Rubrerythrin Daes_0807 ENOG4105MAX Superoxide reductase Daes_0808 ENOG41082X2 rubredoxin Daes_0810 ENOG4108UPT UPF0178 protein Daes_0813 ENOG4105CDV Ompa motb domain protein Daes_0815 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Daes_0816 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Daes_0817 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Daes_0819 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0820 ENOG4105BZU Histidine kinase Daes_0821 ENOG4105CJ3 phosphate transporter Daes_0823 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_0824 ENOG4105C01 Dihydroxy-acid dehydratase Daes_0828 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Daes_0829 ENOG4105VFU Rna-binding protein Daes_0831 ENOG4108UQY Iron-storage protein Daes_0832 ENOG4105C3F Signal peptidase i Daes_0833 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Daes_0839 ENOG4105NCT RNA Polymerase Daes_0842 ENOG4105EAB amino acid AbC transporter Daes_0843 ENOG4105E5Q amino acid AbC transporter Daes_0845 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Daes_0852 ENOG4105C1P efflux transporter, rnd family, mfp subunit Daes_0860 ENOG4105E8R UPF0173 metal-dependent hydrolase Daes_0861 ENOG4105CD5 CoA-binding domain protein Daes_0862 ENOG4105VSH 4-oxalocrotonate tautomerase Daes_0863 ENOG4105F1C cytochrome c Daes_0864 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Daes_0865 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit Daes_0867 ENOG4108SX7 hmc operon protein 5 Daes_0868 ENOG4107QQM Cysteine-rich domain Daes_0869 ENOG4108UVJ appr-1-p processing domain protein Daes_0870 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Daes_0871 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Daes_0872 ENOG4105CYW agmatinase Daes_0874 ENOG4105DTN riboflavin biosynthesis protein ribF Daes_0875 ENOG4105ERG peptidase m48, ste24p Daes_0876 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Daes_0878 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Daes_0879 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Daes_0880 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Daes_0881 ENOG4107Z7S Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Daes_0883 ENOG4107RA9 decarboxylase Daes_0884 ENOG4105C08 Histidine kinase Daes_0885 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0886 ENOG4108YYC ycei family Daes_0888 ENOG4105E0A ABC, transporter Daes_0889 ENOG4105EHG Permease protein Daes_0891 ENOG4105CYW agmatinase Daes_0894 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) Daes_0895 ENOG4105CHW UPF0052 protein Daes_0900 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_0901 ENOG4107QI1 Mate efflux family protein Daes_0904 ENOG4105BZU Histidine kinase Daes_0905 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Daes_0906 ENOG4108KK1 membrane protein AbrB duplication Daes_0907 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Daes_0908 ENOG4105DR5 peptidase Daes_0909 ENOG410873E Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Daes_0910 ENOG4105CTB Polyprenyl synthetase Daes_0911 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Daes_0912 ENOG4105K5B UPF0225 protein Daes_0913 ENOG4108YZN class I peptide chain release factor Daes_0917 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Daes_0920 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Daes_0922 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Daes_0923 ENOG4105BZU Histidine kinase Daes_0924 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_0927 ENOG4108W2P Methyl-accepting chemotaxis Daes_0929 ENOG4105C1J atp-dependent rna helicase Daes_0930 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Daes_0931 ENOG4105VFU Rna-binding protein Daes_0937 ENOG4105DZS Phenylacetate-CoA ligase Daes_0945 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Daes_0946 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Daes_0947 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Daes_0948 ENOG4105DK0 Indole-3-glycerol phosphate synthase Daes_0949 ENOG4108I0Q anthranilate phosphoribosyltransferase Daes_0950 ENOG4105DDQ anthranilate synthase Daes_0951 ENOG4105CRQ synthase (Component I) Daes_0953 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Daes_0954 ENOG4105CQC Prephenate dehydratase Daes_0955 ENOG4106M32 3-dehydroquinate synthase Daes_0956 ENOG41061GT Aldolase Daes_0958 ENOG4108YZA Nitrogen regulatory protein pii Daes_0959 ENOG4105EPM Diguanylate phosphodiesterase Daes_0966 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Daes_0967 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Daes_0968 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Daes_0969 ENOG4108K0B C-di-gmp phosphodiesterase Daes_0971 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Daes_0974 ENOG4105C8Q Methyl-accepting chemotaxis Daes_0976 ENOG4105D0M Protease HtpX homolog Daes_0982 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Daes_0983 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Daes_0984 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Daes_0985 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) Daes_0986 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) Daes_0987 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Daes_0992 ENOG4105EYW Ion transport protein Daes_0999 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Daes_1000 ENOG4105BZU Histidine kinase Daes_1001 ENOG4105BZU Histidine kinase Daes_1002 ENOG4105BZU Histidine kinase Daes_1003 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1007 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1008 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1009 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1011 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1012 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Daes_1013 ENOG4108PJD permease Daes_1016 ENOG4105DSE periplasmic solute binding protein Daes_1017 ENOG4105CIZ coA-substrate-specific enzyme activase Daes_1018 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase Daes_1020 ENOG4107SDT Homocitrate synthase Daes_1021 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Daes_1023 ENOG4108YZA Nitrogen regulatory protein pii Daes_1026 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB Daes_1030 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB Daes_1032 ENOG4108JUA Transcriptional regulator Daes_1034 ENOG4105PWN phosphate abc transporter Daes_1035 ENOG4105C8U phosphate abc transporter Daes_1036 ENOG4105C8U phosphate abc transporter Daes_1037 ENOG4107U4H Methyl-accepting chemotaxis Daes_1038 ENOG4105CCT upf0313 protein Daes_1040 ENOG4105C1J atp-dependent rna helicase Daes_1041 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Daes_1043 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Daes_1046 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Daes_1048 ENOG4105W3H MtN3 and saliva related transmembrane protein Daes_1049 ENOG4105DC1 bifunctional purine biosynthesis protein purh Daes_1050 ENOG4105C8Q Methyl-accepting chemotaxis Daes_1053 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Daes_1054 ENOG4107QRG dna polymerase iii Daes_1061 ENOG4108IJ0 Aspartate ammonia-lyase Daes_1065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1066 ENOG4105K70 DNA-binding protein Daes_1068 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Daes_1069 ENOG4105DAA L-lactate Daes_1070 ENOG4105CQB FAD linked oxidase domain protein Daes_1071 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Daes_1072 ENOG4105C6K Malic enzyme Daes_1073 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Daes_1074 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) Daes_1076 ENOG4107U4H Methyl-accepting chemotaxis Daes_1085 ENOG4105MKQ Monovalent cation H antiporter subunit C Daes_1086 ENOG4108JPZ Monovalent cation H antiporter subunit D Daes_1087 ENOG4108JPZ Monovalent cation H antiporter subunit D Daes_1089 ENOG4108JPZ Monovalent cation H antiporter subunit D Daes_1095 ENOG4108ZXC Two component transcriptional regulator, luxr family Daes_1097 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1100 ENOG4105CHH sulfate transporter Daes_1101 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1103 ENOG4105CJ1 ABC, transporter Daes_1105 ENOG4105I8F Histidine kinase Daes_1108 ENOG4105E3W Two component transcriptional regulator (Winged helix family Daes_1109 ENOG4105I03 Flagellin Daes_1111 ENOG4105W00 Flagellar hook capping protein Daes_1112 ENOG4105BZE flagellar hook protein, FlgE Daes_1113 ENOG4105E1Q flagellar hook-associated protein Daes_1116 ENOG4105EB3 Histidine kinase Daes_1117 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Daes_1119 ENOG4105ENT Efflux transporter rnd family, mfp subunit Daes_1122 ENOG4108NVR Methyl-accepting chemotaxis Daes_1126 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_1127 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Daes_1133 ENOG4105BZU Histidine kinase Daes_1134 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1140 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Daes_1141 ENOG4108IJ9 (ABC) transporter Daes_1142 ENOG4108IJ9 (ABC) transporter Daes_1144 ENOG4108J2R molybdopterin oxidoreductase Daes_1148 ENOG4108JGH Tetr family transcriptional regulator Daes_1152 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Daes_1153 ENOG4105DFM M18 family aminopeptidase Daes_1155 ENOG4105EM7 Selenocysteine-specific translation elongation factor Daes_1157 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Daes_1158 ENOG4107QP3 malate synthase g Daes_1159 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) Daes_1166 ENOG4105FT8 Phosphonate metabolism Daes_1167 ENOG4105ENV phosphonate C-P lyase system protein PhnK Daes_1168 ENOG4105HRV phosphonate c-p lyase system protein phnl Daes_1169 ENOG4105FD8 phosphonate metabolism protein PhnM Daes_1170 ENOG4105D5T phosphonate abc transporter Daes_1177 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Daes_1182 ENOG4107QJE Chromosome Partitioning Protein Daes_1184 ENOG4107QY8 reductase Daes_1190 ENOG4105BZU Histidine kinase Daes_1191 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1195 ENOG4108HU6 Metal dependent phosphohydrolase Daes_1196 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Daes_1197 ENOG4108STX response regulator Daes_1198 ENOG4105MA4 psp1 domain protein Daes_1199 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Daes_1204 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Daes_1206 ENOG4105C2X Arabinose 5-phosphate isomerase Daes_1208 ENOG4108JQC penicillin-binding protein 1A Daes_1209 ENOG4105JAB phenazine biosynthesis protein, phzf family Daes_1210 ENOG4105CFP Peptidase U32 Daes_1211 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Daes_1212 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Daes_1214 ENOG4105C09 Bile acid Daes_1217 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation Daes_1218 ENOG4108JJB ABC transporter Daes_1220 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) Daes_1223 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Daes_1225 ENOG4105DZS Phenylacetate-CoA ligase Daes_1226 ENOG4105CDU Replicative dna helicase Daes_1227 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Daes_1228 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Daes_1229 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Daes_1230 ENOG4105C8V SAICAR synthetase Daes_1231 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Daes_1233 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Daes_1234 ENOG4107T8T UPF0173 metal-dependent hydrolase Daes_1235 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Daes_1238 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Daes_1241 ENOG4107R88 Chemotaxis protein (CheV) Daes_1243 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Daes_1247 ENOG4108IY8 ABC, transporter Daes_1248 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component Daes_1249 ENOG4105C9A Phoh family Daes_1250 ENOG41084FD Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Daes_1252 ENOG4105DBV ornithine carbamoyltransferase Daes_1253 ENOG4105CDH Citrulline--aspartate ligase Daes_1254 ENOG4105CH7 arginosuccinase Daes_1255 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Daes_1257 ENOG4105C8B TIGR00159 family Daes_1259 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Daes_1260 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Daes_1262 ENOG4105C25 Primosomal protein n' Daes_1267 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Daes_1268 ENOG4105D41 biosynthesis protein thiH Daes_1270 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Daes_1271 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Daes_1275 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Daes_1278 ENOG4105CKK Glycosyl transferase, family 2 Daes_1281 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Daes_1282 ENOG4107TAE Glycosyl transferase (Group 1 Daes_1285 ENOG4108N5B 2-phosphosulfolactate phosphatase Daes_1286 ENOG4105BZU Histidine kinase Daes_1288 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Daes_1289 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Daes_1290 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Daes_1291 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Daes_1292 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Daes_1293 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Daes_1294 ENOG4107YX3 NADH dehydrogenase subunit j Daes_1295 ENOG4107EJQ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Daes_1296 ENOG4108JPZ Monovalent cation H antiporter subunit D Daes_1298 ENOG4108JPZ Monovalent cation H antiporter subunit D Daes_1299 ENOG4105C8S subunit m Daes_1300 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Daes_1304 ENOG4105C3G gtp-binding protein Daes_1305 ENOG4107ZC0 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Daes_1306 ENOG4105CZN Potassium uptake protein Daes_1309 ENOG41082IR Excinuclease ABC C subunit domain protein Daes_1310 ENOG4105C5H ABC transporter Daes_1311 ENOG4105M6F mutator MutT protein Daes_1312 ENOG4105SYT Methylenetetrahydrofolate reductase Daes_1313 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Daes_1314 ENOG4105CM2 brancheD-chain amino acid aminotransferase Daes_1317 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Daes_1319 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Daes_1322 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component Daes_1323 ENOG4105C8W ABC transporter Daes_1325 ENOG4105D06 uba thif-type nad fad binding protein Daes_1327 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Daes_1331 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_1335 ENOG4105DGN Electron transport complex Daes_1336 ENOG4105DZB Electron transport complex Daes_1338 ENOG4105D6A Electron transport complex Daes_1340 ENOG4105F1C cytochrome c Daes_1343 ENOG4105C3M thioredoxin reductase Daes_1344 ENOG4105BZU Histidine kinase Daes_1347 ENOG4108VYJ response regulator receiver protein Daes_1351 ENOG4108Z0T Part of a sulfur-relay system (By similarity) Daes_1352 ENOG41082DI 50s ribosomal protein l31 Daes_1353 ENOG4105CBJ Metal-dependent enzyme Daes_1354 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Daes_1355 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Daes_1356 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Daes_1361 ENOG4108VYJ response regulator receiver protein Daes_1362 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Daes_1364 ENOG4105FZW flagellar biosynthesis regulator FlhF Daes_1365 ENOG4105D7B Flagellar biosynthesis protein flha Daes_1366 ENOG4105D00 flagellar biosynthetic protein flhB Daes_1367 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Daes_1368 ENOG4105DR5 peptidase Daes_1369 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Daes_1371 ENOG41084BP Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Daes_1372 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Daes_1373 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Daes_1374 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Daes_1375 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Daes_1376 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Daes_1379 ENOG4105DC7 peptidase M24 Daes_1381 ENOG4105C0A alcohol dehydrogenase Daes_1382 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Daes_1384 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Daes_1388 ENOG4107TPS domain protein Daes_1391 ENOG4107QWP ABC-2 type transporter Daes_1392 ENOG4105CJ1 ABC, transporter Daes_1396 ENOG4105CRK lysyL-tRNA synthetase Daes_1397 ENOG4105D60 lipoprotein releasing system transmembrane protein Daes_1398 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Daes_1399 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Daes_1401 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Daes_1402 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Daes_1403 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Daes_1404 ENOG4105GYT Protein of unknown function (DUF1009) Daes_1407 ENOG4107S2Z UPF0761 membrane protein Daes_1409 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Daes_1411 ENOG4105VF7 tolerance protein Daes_1414 ENOG4107RIQ Sulfate adenylate transferase Daes_1415 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Daes_1418 ENOG4105E02 MotA TolQ exbB proton channel Daes_1419 ENOG4108ZZF transport protein (ExbD) Daes_1421 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Daes_1422 ENOG4105KCK Peptidoglycan-associated lipoprotein Daes_1423 ENOG4108ZAI phosphatidylglycerophosphatase a Daes_1425 ENOG4108Z03 MAF-like protein Daes_1427 ENOG4107R0U MotA TolQ exbB proton channel Daes_1429 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Daes_1431 ENOG4105UIB (ABC) transporter Daes_1433 ENOG4105C2J ABC transporter Daes_1434 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Daes_1438 ENOG4105E3H phosphoglycerate mutase Daes_1439 ENOG4105D6E homoserine dehydrogenase Daes_1440 ENOG4105CHM Aminotransferase Daes_1441 ENOG4105CM2 brancheD-chain amino acid aminotransferase Daes_1442 ENOG4105C6E dna polymerase iii Daes_1443 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Daes_1444 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Daes_1445 ENOG4105C7H Helicase, RecD TraA family Daes_1448 ENOG4105DQU oxidoreductase, subunit beta Daes_1449 ENOG4105C5H ABC transporter Daes_1451 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Daes_1452 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Daes_1454 ENOG4105F8J Adenylate Guanylate cyclase Daes_1456 ENOG4108JJA ABC, transporter Daes_1461 ENOG4105C8Q Methyl-accepting chemotaxis Daes_1467 ENOG4108Z6B deaminase Daes_1468 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Daes_1469 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Daes_1470 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Daes_1474 ENOG4108IUZ ABC transporter Daes_1475 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Daes_1477 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Daes_1478 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Daes_1480 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB Daes_1482 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase Daes_1483 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Daes_1485 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Daes_1487 ENOG4105BZU Histidine kinase Daes_1488 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Daes_1489 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Daes_1490 ENOG4108JU5 Magnesium and cobalt efflux protein Daes_1491 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Daes_1492 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Daes_1494 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Daes_1495 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Daes_1496 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Daes_1497 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Daes_1498 ENOG4105K70 DNA-binding protein Daes_1500 ENOG41084JP 30S ribosomal protein S21 Daes_1501 ENOG4105KTH gatB Yqey Daes_1502 ENOG4105C98 muts2 protein Daes_1503 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Daes_1504 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Daes_1505 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Daes_1507 ENOG4105II7 pyrroline-5-carboxylate reductase Daes_1508 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Daes_1509 ENOG4105D5T phosphonate abc transporter Daes_1510 ENOG4105C7J ABC transporter, permease Daes_1512 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Daes_1514 ENOG4105CN1 protease Daes_1517 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Daes_1519 ENOG4105C8Y Acetylornithine aminotransferase Daes_1524 ENOG4105CBC glutamate synthase Daes_1525 ENOG4108RC0 Electron transport protein Daes_1526 ENOG4108IFG nitrite reductase, (NAD(P)H) Daes_1527 ENOG4105EYU Glutamine amido-transferase Daes_1529 ENOG4105VIE preprotein translocase, subunit YajC Daes_1530 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Daes_1531 ENOG4108JIS Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Daes_1532 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Daes_1533 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Daes_1535 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Daes_1536 ENOG4105CRE cytochrome C Daes_1537 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Daes_1542 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Daes_1544 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Daes_1545 ENOG4105CFV Tetratricopeptide repeat protein Daes_1550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Daes_1551 ENOG4105CHM Aminotransferase Daes_1557 ENOG4105CP7 Triose-phosphate isomerase Daes_1558 ENOG4105BZA Phosphoglycerate kinase Daes_1559 ENOG410801F ribosomal-protein-alanine acetyltransferase Daes_1561 ENOG4105ECY inositol monophosphatase Daes_1564 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Daes_1568 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Daes_1569 ENOG4105CNU cell division protein FtsK Daes_1570 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Daes_1571 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Daes_1572 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Daes_1576 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Daes_1579 ENOG4108C33 Resolvase Daes_1582 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Daes_1592 ENOG4105C7H Helicase, RecD TraA family Daes_1593 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Daes_1607 ENOG4105C5S asparaginyl-tRNA synthetase Daes_1652 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Daes_1657 ENOG4105C0D helicase Daes_1660 ENOG4105D64 Mechanosensitive ion channel Daes_1661 ENOG4108K0D peptidase, M48 Daes_1664 ENOG4107V8I Glycosyl transferases group 1 Daes_1670 ENOG4105CP9 extracellular ligand-binding receptor Daes_1671 ENOG4105BZU Histidine kinase Daes_1672 ENOG4106VK6 Flagellar motor protein Daes_1673 ENOG4106VK6 Flagellar motor protein Daes_1674 ENOG4105E14 MotA TolQ exbB proton channel Daes_1678 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Daes_1680 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Daes_1682 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Daes_1684 ENOG4105BZU Histidine kinase Daes_1686 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Daes_1690 ENOG4105DIW FeS assembly protein SUFB Daes_1691 ENOG4105C3K feS assembly ATPase SufC Daes_1693 ENOG4108V3W Chemotaxis protein, CheW Daes_1695 ENOG4105M71 acetolactate synthase 1 regulatory subunit Daes_1696 ENOG4105C7K acetolactate synthase Daes_1697 ENOG4105DYS nad(p)h dehydrogenase (quinone) Daes_1699 ENOG4105DAN ATP-dependent protease Daes_1702 ENOG4105BZU Histidine kinase Daes_1705 ENOG4105C3J Cysteine desulfurase Daes_1707 ENOG4105D7W serine acetyltransferase Daes_1709 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Daes_1710 ENOG4107TEJ This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Daes_1716 ENOG4105CJW magnesium transporter Daes_1717 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Daes_1718 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Daes_1719 ENOG4108IYU L-aspartate oxidase Daes_1720 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Daes_1721 ENOG4105C1A potassium transporter peripheral membrane Daes_1722 ENOG4107RZH Nitrite and sulphite reductase 4Fe-4S region Daes_1723 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Daes_1726 ENOG4105IJJ transcriptional regulator, crp fnr family Daes_1727 ENOG4108317 Binds directly to 16S ribosomal RNA (By similarity) Daes_1728 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Daes_1729 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Daes_1730 ENOG4107Z50 Involved in DNA repair and RecF pathway recombination (By similarity) Daes_1732 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Daes_1734 ENOG4108JA2 transcriptioN-repair coupling factor Daes_1735 ENOG4108V3W Chemotaxis protein, CheW Daes_1737 ENOG4105C6Y Udp-glucose 6-dehydrogenase Daes_1738 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Daes_1739 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Daes_1740 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Daes_1741 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Daes_1743 ENOG4105CFH Aspartokinase Daes_1744 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Daes_1745 ENOG4105D58 Diguanylate phosphodiesterase Daes_1747 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Daes_1748 ENOG4105EQI Metal Dependent Phosphohydrolase Daes_1749 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Daes_1750 ENOG4105E5Q amino acid AbC transporter Daes_1752 ENOG4106TNF Periplasmic binding protein Daes_1753 ENOG4105DRP amino acid AbC transporter Daes_1756 ENOG4105DZP Membrane-associated zinc metalloprotease Daes_1758 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Daes_1759 ENOG4105C3U ABC transporter Daes_1760 ENOG4108JQ7 (ABC) transporter Daes_1763 ENOG4108JJB ABC transporter Daes_1764 ENOG4107QI1 Mate efflux family protein Daes_1768 ENOG4105C4R Atp-dependent dna helicase Daes_1769 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Daes_1770 ENOG4108R96 Methyltransferase, YaeB family Daes_1771 ENOG4107S9D Alpha beta hydrolase Daes_1772 ENOG4108U5N UPF0316 protein Daes_1773 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Daes_1774 ENOG4108ZP8 Acetolactate synthase small subunit Daes_1775 ENOG4105C7K acetolactate synthase Daes_1777 ENOG4105VZ9 UPF0235 protein Daes_1783 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Daes_1787 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Daes_1788 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Daes_1789 ENOG4106H78 methyltransferase Daes_1790 ENOG4105CY0 Metallo-Beta-Lactamase Daes_1791 ENOG4108URH decarboxylase Daes_1792 ENOG4107RT3 EamA-like transporter family Daes_1795 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Daes_1798 ENOG4105DZS Phenylacetate-CoA ligase Daes_1803 ENOG4105UQX Mate efflux family protein Daes_1804 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Daes_1806 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Daes_1807 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Daes_1808 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Daes_1810 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Daes_1811 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Daes_1812 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Daes_1814 ENOG4105WMR Protein CrcB homolog Daes_1815 ENOG4105KJJ Uncharacterized ACR, COG1993 Daes_1816 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Daes_1817 ENOG4105CBS Chea signal transduction histidine kinase Daes_1818 ENOG4107U4H Methyl-accepting chemotaxis Daes_1820 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Daes_1822 ENOG4107SG8 outer membrane assembly lipoprotein YfiO Daes_1823 ENOG4105C3M thioredoxin reductase Daes_1824 ENOG4105K63 Thioredoxin Daes_1825 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Daes_1826 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Daes_1831 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Daes_1832 ENOG4105D1F ATP-binding protein Daes_1834 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Daes_1838 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Daes_1840 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Daes_1841 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Daes_1842 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Daes_1843 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Daes_1848 ENOG4108YXV Transcriptional regulator Daes_1850 ENOG4105C5S asparaginyl-tRNA synthetase Daes_1851 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Daes_1852 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Daes_1855 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Daes_1858 ENOG4105D5U fad dependent oxidoreductase Daes_1860 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Daes_1861 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Daes_1863 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Daes_1865 ENOG4105C79 DNA protecting protein DprA Daes_1871 ENOG4105CBS Chea signal transduction histidine kinase Daes_1872 ENOG4108VYJ response regulator receiver protein Daes_1873 ENOG4105BZU Histidine kinase Daes_1875 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Daes_1883 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Daes_1885 ENOG4105QNJ serralysin (EC 3.4.24.40) Daes_1886 ENOG4107RRZ synthase Daes_1889 ENOG4105CE1 Ferrous iron transport protein b Daes_1890 ENOG4105XFK Ferrous iron transport protein A Daes_1892 ENOG41090R7 Ferric uptake Daes_1894 ENOG41090R7 Ferric uptake Daes_1896 ENOG4105EZM VWA-like domain (DUF2201) Daes_1901 ENOG4105BZU Histidine kinase Daes_1903 ENOG4105EJQ L-serine dehydratase Daes_1905 ENOG4106PMH Extracellular solute-binding protein family 3 Daes_1906 ENOG4105DRP amino acid AbC transporter Daes_1909 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Daes_1910 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Daes_1911 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Daes_1912 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Daes_1913 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Daes_1914 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme Daes_1917 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Daes_1921 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Daes_1923 ENOG4105K64 Glycosyl transferase, family 2 Daes_1928 ENOG4108RIR Molybdenum cofactor biosynthesis protein Daes_1944 ENOG4105VYW UPF0251 protein Daes_1953 ENOG4105BZ8 glutamate synthase Daes_1954 ENOG4105CBC glutamate synthase Daes_1960 ENOG4105IPI Membrane Daes_1961 ENOG4106PMH Extracellular solute-binding protein family 3 Daes_1962 ENOG4105EAD ABC transporter Daes_1968 ENOG4105CHR reductase Daes_1971 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Daes_1972 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Daes_1973 ENOG4108HHA Transketolase Daes_1975 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Daes_1977 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Daes_1984 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Daes_1985 ENOG4105D2T synthase Daes_1987 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Daes_1988 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Daes_1991 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Daes_1992 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Daes_1996 ENOG4105BZU Histidine kinase Daes_1998 ENOG4105BZU Histidine kinase Daes_2005 ENOG4105CE1 Ferrous iron transport protein b Daes_2007 ENOG4105DC1 bifunctional purine biosynthesis protein purh Daes_2009 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Daes_2010 ENOG4108ZC9 flagellar basal-body rod protein flgc Daes_2011 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Daes_2012 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Daes_2013 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Daes_2016 ENOG4108UXE Protein tyrosine phosphatase Daes_2018 ENOG4108XDN Transcriptional regulator Daes_2019 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Daes_2020 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Daes_2021 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Daes_2022 ENOG4105VJV 50s ribosomal protein L35 Daes_2023 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Daes_2024 ENOG4105C22 threonyL-tRNA synthetase Daes_2030 ENOG4105Z5G 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Daes_2033 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Daes_2035 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Daes_2037 ENOG4105KME endoribonuclease L-psp Daes_2038 ENOG41061GT Aldolase Daes_2040 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Daes_2044 ENOG4105XA0 heptosyltransferase ii Daes_2053 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Daes_2054 ENOG4105C3U ABC transporter Daes_2055 ENOG4108JQ7 (ABC) transporter Daes_2059 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Daes_2060 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Daes_2061 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Daes_2064 ENOG4106DSS Tartrate dehydratase subunit alpha Daes_2065 ENOG4105E33 succinate dehydrogenase Daes_2066 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Daes_2067 ENOG4108S24 Fumarate reduCtase Daes_2068 ENOG4105C1V Peptidase, M16 Daes_2070 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Daes_2071 ENOG4107ZYR domain protein Daes_2072 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Daes_2074 ENOG4105C0D helicase Daes_2080 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Daes_2081 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Daes_2083 ENOG4106VK6 Flagellar motor protein Daes_2084 ENOG4105E14 MotA TolQ exbB proton channel Daes_2088 ENOG4105DQU oxidoreductase, subunit beta Daes_2089 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Daes_2091 ENOG41081F0 Precorrin-8x methylmutase Daes_2092 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Daes_2093 ENOG4105DRP amino acid AbC transporter Daes_2094 ENOG4105EAD ABC transporter Daes_2095 ENOG4105CT1 (ABC) transporter Daes_2098 ENOG4105BZS acriflavin resistance protein Daes_2099 ENOG4105XA0 heptosyltransferase ii Daes_2101 ENOG4105DZC cytosine deaminase Daes_2102 ENOG4105EU4 polysulphide reductase NrfD Daes_2103 ENOG4107SFQ iron-sulfur binding Daes_2104 ENOG4107UQT molybdopterin oxidoreductase Daes_2106 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Daes_2109 ENOG4105DXN mazG family Daes_2111 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Daes_2112 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase Daes_2115 ENOG41090R7 Ferric uptake Daes_2117 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Daes_2118 ENOG4105C1J atp-dependent rna helicase Daes_2121 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Daes_2122 ENOG4107U4H Methyl-accepting chemotaxis Daes_2123 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Daes_2124 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Daes_2128 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Daes_2131 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Daes_2132 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Daes_2134 ENOG4105E1Q flagellar hook-associated protein Daes_2134 ENOG4105E1Q flagellar hook-associated protein Daes_2137 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Daes_2138 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Daes_2140 ENOG4105CGA flagellar basal-body rod protein FlgG Daes_2141 ENOG4105CGA flagellar basal-body rod protein FlgG Daes_2142 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Daes_2143 ENOG4105CHV Transcription elongation factor NusA Daes_2145 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Daes_2145 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Daes_2147 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Daes_2149 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Daes_2150 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Daes_2151 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Daes_2152 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein Daes_2154 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2156 ENOG4105DZ0 fad dependent oxidoreductase Daes_2159 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) Daes_2160 ENOG4105MRR Transcriptional regulator (By similarity) Daes_2162 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Daes_2163 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Daes_2164 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Daes_2165 ENOG4107QN2 dihydrolipoyl dehydrogenase Daes_2166 ENOG4105CHR reductase Daes_2170 ENOG4105CEM UPF0597 protein Daes_2175 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Daes_2180 ENOG4105CE9 30S ribosomal protein S2 Daes_2181 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Daes_2182 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Daes_2183 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Daes_2184 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Daes_2185 ENOG4105KNE Phosphatidate cytidylyltransferase Daes_2186 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Daes_2187 ENOG4105DZP Membrane-associated zinc metalloprotease Daes_2188 ENOG41072GX Peptidase M22 Glycoprotease Daes_2189 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Daes_2190 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) Daes_2196 ENOG4105I03 Flagellin Daes_2199 ENOG4105CPK Glycosyl transferase (Group 1 Daes_2203 ENOG4105UYK outer membrane protein a Daes_2204 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Daes_2205 ENOG4105D52 delta-aminolevulinic acid dehydratase Daes_2206 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Daes_2210 ENOG4105C5H ABC transporter Daes_2212 ENOG4105C26 Dehydrogenase Daes_2213 ENOG4105EW9 transcriptional regulator AsnC family Daes_2214 ENOG4105CY3 ABC transporter, permease Daes_2215 ENOG4105DHJ ABC, transporter Daes_2218 ENOG4105N42 UPF0307 protein Daes_2220 ENOG410631K Membrane Daes_2221 ENOG4105E63 Pfam:DUF178 Daes_2223 ENOG4105DVY radical SAM domain protein Daes_2224 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Daes_2226 ENOG4105DUM transcriptional regulator, lysR family Daes_2227 ENOG4108ZT0 50S ribosomal protein l17 Daes_2228 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Daes_2229 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Daes_2230 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Daes_2231 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Daes_2232 ENOG41067V7 50S ribosomal protein L36 Daes_2234 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Daes_2235 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Daes_2236 ENOG41087HB 50S ribosomal protein L30 Daes_2237 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Daes_2238 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Daes_2239 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Daes_2240 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Daes_2241 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Daes_2242 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Daes_2243 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Daes_2244 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Daes_2245 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Daes_2246 ENOG41082SA 50s ribosomal protein l29 Daes_2247 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Daes_2248 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Daes_2249 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Daes_2250 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Daes_2251 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Daes_2252 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Daes_2253 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Daes_2254 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Daes_2255 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Daes_2256 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Daes_2257 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Daes_2258 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Daes_2259 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Daes_2260 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Daes_2261 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Daes_2262 ENOG4108VZM 50s ribosomal protein L10 Daes_2263 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Daes_2264 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Daes_2265 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Daes_2266 ENOG4105PM1 preprotein translocase subunit SecE Daes_2267 ENOG41084ED 50S ribosomal protein L33 Daes_2268 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Daes_2269 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Daes_2270 ENOG4107R88 Chemotaxis protein (CheV) Daes_2271 ENOG4105C45 hydrogenase expression formation protein (HypE) Daes_2272 ENOG4105CQS hydrogenase expression formation protein HypD Daes_2276 ENOG4105CPF Cell wall formation (By similarity) Daes_2279 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Daes_2283 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Daes_2284 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Daes_2285 ENOG4108TIT dATP pyrophosphohydrolase Daes_2286 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Daes_2287 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase Daes_2288 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2290 ENOG4105CBS Chea signal transduction histidine kinase Daes_2291 ENOG4107PPM cobalt chelatase Daes_2292 ENOG4105EHG Permease protein Daes_2293 ENOG4105E0A ABC, transporter Daes_2295 ENOG4105DVK Precorrin-2 c20-methyltransferase Daes_2296 ENOG4107PPM cobalt chelatase Daes_2302 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Daes_2303 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Daes_2304 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Daes_2309 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Daes_2312 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Daes_2313 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Daes_2314 ENOG4105KC4 UPF0296 protein Daes_2315 ENOG4105DSJ YicC domain protein Daes_2317 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Daes_2320 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Daes_2321 ENOG4105DCT glycerol dehydrogenase Daes_2322 ENOG4105DZW Dipeptidase Daes_2323 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Daes_2324 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Daes_2326 ENOG4105CFG Acts as a chaperone (By similarity) Daes_2327 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Daes_2330 ENOG4105DNZ Alpha Beta Hydrolase Daes_2332 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Daes_2335 ENOG4105K3G Periplasmic Protein Daes_2336 ENOG4105E3H phosphoglycerate mutase Daes_2338 ENOG4105C34 Pseudouridine synthase Daes_2339 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Daes_2340 ENOG4105C2W permease Daes_2341 ENOG4106WTF Glycosyl transferase, family 2 Daes_2343 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Daes_2350 ENOG4105C6T cysteine synthase Daes_2351 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Daes_2355 ENOG4108JUA Transcriptional regulator Daes_2358 ENOG4107XZA Glycosyl transferase family 2 Daes_2361 ENOG4105VEQ Cold shock protein Daes_2362 ENOG4105DKW ABC transporter Daes_2365 ENOG4108JQ1 Dehydrogenase Daes_2367 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Daes_2368 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Daes_2369 ENOG4105C8Q Methyl-accepting chemotaxis Daes_2371 ENOG4108HM5 NADH-ubiquinone oxidoreductase chain 49kDa Daes_2373 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Daes_2375 ENOG4105D65 subunit l Daes_2376 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Daes_2379 ENOG4105CMM transposase Daes_2386 ENOG4105Y0G tail protein Daes_2387 ENOG4108T86 baseplate J family protein Daes_2388 ENOG4105WR6 Phage protein, GP46 Daes_2389 ENOG4105PZ7 Baseplate assembly protein Daes_2391 ENOG4108NKR DNA circulation protein Daes_2394 ENOG41062PQ Mu-like prophage FluMu protein gp41 Daes_2396 ENOG4105TKZ Tail Sheath Daes_2402 ENOG4105EFV Major head subunit Daes_2406 ENOG4105QIB mu-like prophage Flumu protein gp29 Daes_2407 ENOG4105CF2 Mu-like prophage FluMu protein GP28 Daes_2437 ENOG4105CQB FAD linked oxidase domain protein Daes_2438 ENOG4105BZU Histidine kinase Daes_2440 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Daes_2441 ENOG4105HHA aminodeoxychorismate lyase Daes_2443 ENOG4105K64 Glycosyl transferase, family 2 Daes_2444 ENOG4107R56 PP-loop domain protein Daes_2446 ENOG410812K response regulator receiver protein Daes_2447 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Daes_2453 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Daes_2454 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Daes_2455 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Daes_2456 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Daes_2457 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Daes_2458 ENOG4108IV0 ABC, transporter Daes_2459 ENOG4105C0Z ABC transporter Daes_2460 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Daes_2461 ENOG4105C32 Amino acid ABC transporter (Permease) Daes_2462 ENOG4105CP9 extracellular ligand-binding receptor Daes_2465 ENOG41060IM Heme exporter protein Daes_2467 ENOG4105CJ1 ABC, transporter Daes_2468 ENOG4105DA4 cytochrome c-type biogenesis protein Daes_2469 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) Daes_2472 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Daes_2473 ENOG4108Z4T Peptidase M50 Daes_2474 ENOG4105C31 Tryptophanyl-tRNA synthetase Daes_2475 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase Daes_2476 ENOG4105CHM Aminotransferase Daes_2479 ENOG4105E0X reductase Daes_2482 ENOG4105BZS acriflavin resistance protein Daes_2483 ENOG4105ENT Efflux transporter rnd family, mfp subunit Daes_2492 ENOG4105HF0 Membrane Daes_2494 ENOG4105JXH GntR family transcriptional regulator Daes_2496 ENOG4107RN3 metallophosphoesterase Daes_2498 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Daes_2507 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Daes_2508 ENOG4105C83 adenylosuccinate lyase Daes_2514 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Daes_2515 ENOG4105BZU Histidine kinase Daes_2516 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2517 ENOG4107R88 Chemotaxis protein (CheV) Daes_2519 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_2520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Daes_2521 ENOG4105ES5 Histidine kinase Daes_2523 ENOG4105BZU Histidine kinase Daes_2524 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Daes_2545 ENOG4105DBI uridine monophosphokinase Daes_2548 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2551 ENOG4105D2N Aldolase Daes_2552 ENOG4105CA9 Pyruvate kinase Daes_2553 ENOG4105BZA Phosphoglycerate kinase Daes_2554 ENOG4105CV1 Transketolase (EC 2.2.1.1) Daes_2556 ENOG4105P52 geranylgeranyl reductase Daes_2560 ENOG4105CMM transposase Daes_2563 ENOG4105CKT filamentous hemagglutinin Daes_2564 ENOG4105D5K Hemolysin activator protein Daes_2572 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Daes_2573 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Daes_2574 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Daes_2575 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Daes_2576 ENOG4108753 50S ribosomal protein l34 Daes_2579 ENOG4105IJJ transcriptional regulator, crp fnr family Daes_2582 ENOG4105E3S small subunit Daes_2583 ENOG4105DPX Hydrogenase, large subunit Daes_2584 ENOG4108USZ hydrogenase Daes_2585 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF Daes_2586 ENOG4105CGH 5'-nucleotidase Daes_2588 ENOG4105NBK UPF0345 protein Daes_2590 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_2595 ENOG4108URH decarboxylase Daes_2597 ENOG4108PHJ Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response Daes_2601 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Daes_2602 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Daes_2603 ENOG4105KAC Antibiotic biosynthesis monooxygenase Daes_2605 ENOG4105WE2 aldehyde ferredoxin oxidoreductase Daes_2608 ENOG4105D6J arsenicaL-resistance protein Daes_2612 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Daes_2613 ENOG4105CDY transcriptional regulatory protein Daes_2614 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Daes_2616 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Daes_2617 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Daes_2618 ENOG4105VCQ rubredoxin Daes_2621 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Daes_2622 ENOG4105E0C molybdate abc transporter Daes_2623 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Daes_2625 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Daes_2629 ENOG4105BZU Histidine kinase Daes_2629 ENOG4105BZU Histidine kinase Daes_2636 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2638 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2641 ENOG41062QK Cytochrome c class III Daes_2642 ENOG4107QQM Cysteine-rich domain Daes_2653 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Daes_2654 ENOG4105CEY Amp-dependent synthetase and ligase Daes_2655 ENOG4105BZU Histidine kinase Daes_2657 ENOG4108UMN azlc family Daes_2658 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Daes_2659 ENOG4105FR1 rard protein Daes_2664 ENOG4105BZU Histidine kinase Daes_2665 ENOG4105BZU Histidine kinase Daes_2670 ENOG4107T0K Adenylate cyclase Daes_2672 ENOG4105FDK ABC transporter Daes_2674 ENOG4105D17 glycoside hydrolase, family 3 domain protein Daes_2676 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Daes_2677 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Daes_2678 ENOG4108HMX isocitrate dehydrogenase (NADP) Daes_2681 ENOG4105D3G Pseudouridine synthase Daes_2683 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Daes_2685 ENOG4105C2J ABC transporter Daes_2686 ENOG4105UIB (ABC) transporter Daes_2688 ENOG4105C5I Dehydrogenase Daes_2690 ENOG4108UQS dipeptidase Daes_2692 ENOG4105BZU Histidine kinase Daes_2693 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Daes_2695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2697 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2698 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2705 ENOG4107AYK membrAne Daes_2707 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Daes_2710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2713 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Daes_2714 ENOG4105CPF Cell wall formation (By similarity) Daes_2715 ENOG4105CPF Cell wall formation (By similarity) Daes_2717 ENOG41067B5 Histone deacetylase superfamily protein Daes_2718 ENOG4108TGR phosphatase Daes_2726 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Daes_2727 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Daes_2728 ENOG4105HFZ Membrane Daes_2729 ENOG4105RAK Histidine kinase Daes_2734 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Daes_2735 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Daes_2736 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Daes_2737 ENOG4108UJD 30S ribosomal protein S9 Daes_2740 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein Daes_2742 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Daes_2743 ENOG4108UT2 hemolysin iii Daes_2745 ENOG4105VFU Rna-binding protein Daes_2748 ENOG4105D1F ATP-binding protein Daes_2750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2751 ENOG4107RSS Hydrogenase accessory protein HypB Daes_2752 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Daes_2753 ENOG4105BZU Histidine kinase Daes_2754 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Daes_2756 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Daes_2757 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Daes_2763 ENOG4105CXB phosphoribosylaminoimidazole synthetase Daes_2764 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Daes_2769 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_2771 ENOG4108V6E Cell division protein mraZ Daes_2772 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Daes_2775 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Daes_2776 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Daes_2777 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Daes_2778 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Daes_2779 ENOG4105CNI cell division protein FtsW Daes_2780 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Daes_2781 ENOG4105DFU Cell wall formation (By similarity) Daes_2782 ENOG4105D4A Cell wall formation (By similarity) Daes_2783 ENOG4108UFP Essential cell division protein (By similarity) Daes_2784 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Daes_2785 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Daes_2786 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Daes_2788 ENOG4105CMM transposase Daes_2793 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Daes_2794 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Daes_2795 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Daes_2796 ENOG4105CHR reductase Daes_2797 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Daes_2798 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Daes_2799 ENOG41084CW 50S ribosomal protein L32 Daes_2801 ENOG4105VB9 50S ribosomal protein l28 Daes_2805 ENOG4107WHI formate dehydrogenase, beta subunit Daes_2806 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Daes_2807 ENOG41083MR nifu domain-containing protein Daes_2808 ENOG4105C5X domain protein Daes_2809 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2810 ENOG4105BZU Histidine kinase Daes_2814 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Daes_2816 ENOG4108R6K riboflavin synthase, subunit alpha Daes_2818 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Daes_2819 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Daes_2820 ENOG4105M7K Involved in the transcription termination process (By similarity) Daes_2822 ENOG41066FR extracellular solute-binding protein Daes_2827 ENOG4105W5Q DNA repair protein (RadC Daes_2828 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Daes_2829 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Daes_2835 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Daes_2842 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Daes_2843 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Daes_2847 ENOG4108IV0 ABC, transporter Daes_2851 ENOG4105C32 Amino acid ABC transporter (Permease) Daes_2852 ENOG4108IQE Amp-dependent synthetase and ligase Daes_2853 ENOG4105C0Z ABC transporter Daes_2856 ENOG4107Y2X deaminase Daes_2857 ENOG4105CIH Imidazole acetol-phosphate transaminase Daes_2859 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Daes_2860 ENOG4106TNF Periplasmic binding protein Daes_2865 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_2871 ENOG4108TVJ Nitroreductase Daes_2874 ENOG4105MJ2 Competence protein Daes_2875 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Daes_2876 ENOG4105K46 50S ribosomal protein l27 Daes_2877 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Daes_2878 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Daes_2879 ENOG4105C6X Major Facilitator Daes_2882 ENOG4105CAS nag kinase Daes_2883 ENOG4105W3S hemerythrin-like, metal-binding protein Daes_2884 ENOG4105CVM Molybdenum cofactor synthesis domain protein Daes_2886 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Daes_2894 ENOG4105BZU Histidine kinase Daes_2899 ENOG4108ERU trap dicarboxylate transporter subunit DctP Daes_2900 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Daes_2902 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Daes_2903 ENOG4105DCF alanine dehydrogenase Daes_2917 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_2922 ENOG4107R0W ABC transporter Daes_2924 ENOG4105CX6 glutaminyL-tRNA synthetase Daes_2926 ENOG4107W2M Sodium hydrogen exchanger Daes_2935 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Daes_2937 ENOG4105RD8 TRAP dicarboxylate transporter Daes_2939 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Daes_2943 ENOG4105EI2 Pseudouridine synthase Daes_2945 ENOG4105K4H Nlp p60 protein Daes_2946 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Daes_2947 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Daes_2948 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Daes_2950 ENOG4105BZU Histidine kinase Daes_2952 ENOG4105BZU Histidine kinase Daes_2954 ENOG4105C72 UPF0176 protein Daes_2955 ENOG4107XKF NMT1 THI5 Like Domain Protein Daes_2961 ENOG4105C3G gtp-binding protein Daes_2966 ENOG4105C8Q Methyl-accepting chemotaxis Daes_2969 ENOG4107R88 Chemotaxis protein (CheV) Daes_2970 ENOG4105D2T synthase Daes_2972 ENOG4105CEY Amp-dependent synthetase and ligase Daes_2974 ENOG4105C32 Amino acid ABC transporter (Permease) Daes_2976 ENOG4105C0Z ABC transporter Daes_2977 ENOG4108IV0 ABC, transporter Daes_2980 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Daes_2982 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Daes_2983 ENOG4105Z0W Dissimilatory sulfite reductase D Daes_2984 ENOG4105PJW Sulfite reductase dissimilatory-type beta subunit Daes_2985 ENOG4105CY1 sulfite reductase, dissimilatory-type alpha subunit Daes_2988 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Daes_2989 ENOG4105BZU Histidine kinase Daes_2992 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Daes_2995 ENOG4105C6K Malic enzyme Daes_3000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Daes_3005 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Daes_3009 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Daes_3010 ENOG4105CIA precorrin-4 C(11)-methyltransferase Daes_3012 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Daes_3013 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Daes_3014 ENOG4105CGK Exodeoxyribonuclease III Daes_3016 ENOG4105CBX hi0933 family Daes_3017 ENOG4105CAT Cytidine monophosphate kinase Daes_3018 ENOG4105CIH Imidazole acetol-phosphate transaminase Daes_3019 ENOG41081QV Universal stress protein Daes_3021 ENOG4108IV0 ABC, transporter Daes_3022 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Daes_3023 ENOG4105C32 Amino acid ABC transporter (Permease) Daes_3024 ENOG4105CP9 extracellular ligand-binding receptor Daes_3025 ENOG4105C0Z ABC transporter Daes_3026 ENOG4105GIJ Glycine betaine Daes_3027 ENOG4108HQS Glycine betaine Daes_3028 ENOG4108IJ7 Glycine betaine Daes_3035 ENOG4107RIQ Sulfate adenylate transferase Daes_3038 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Daes_3043 ENOG4105W00 Flagellar hook capping protein Daes_3044 ENOG4105BZE flagellar hook protein, FlgE Daes_3045 ENOG4105I03 Flagellin Daes_3046 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Daes_3051 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Daes_3053 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Daes_3054 ENOG4108UTW Plays a role in the regulation of phosphate uptake Daes_3055 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Daes_3059 ENOG4107FQX Alpha-acetolactate decarboxylase Daes_3060 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Daes_3062 ENOG4105EWC Purine nucleoside phosphorylase Daes_3069 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Daes_3071 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Daes_3073 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Daes_3074 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Daes_3075 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Daes_3077 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) Daes_3078 ENOG4105BZU Histidine kinase Daes_3081 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase Daes_3083 ENOG4105PW4 Sugar fermentation stimulation protein homolog Daes_3088 ENOG4105DWV Homoserine O-trans-acetylase Daes_3091 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Daes_3092 ENOG4108T9Y Inner membrane protein ydcZ Daes_3093 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Daes_3094 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase Daes_3099 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Daes_3100 ENOG4105CHM Aminotransferase Daes_3101 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Daes_3102 ENOG4105D48 metallophosphoesterase Daes_3103 ENOG4105BZU Histidine kinase Daes_3104 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Daes_3107 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Daes_3108 ENOG41082MC Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Daes_3109 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Daes_3110 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Daes_3111 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Daes_3112 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Daes_3113 ENOG410835G Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Daes_3116 ENOG4105CNI cell division protein FtsW Daes_3117 ENOG4105CJN penicillin-binding protein Daes_3120 ENOG4105DFF Rod shape-determining protein mreb Daes_3123 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Daes_3124 ENOG4105VH4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Daes_3125 ENOG4107WJT it plays a direct role in the translocation of protons across the membrane (By similarity) Daes_3127 ENOG4106884 ATP synthase Daes_3129 ENOG4108UGV hypoxanthine phosphoribosyltransferase Daes_3132 ENOG4105C3R Methionine synthase Daes_3133 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Daes_3137 ENOG4108YZG isomerase Daes_3145 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Daes_3146 ENOG4105C59 p-type ATPase Daes_3147 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) Daes_3149 ENOG4108I5C dEAD DEAH box helicase Daes_3150 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Daes_3154 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Daes_3155 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Daes_3157 ENOG4105EUZ Beta-lactamase domain protein Daes_3163 ENOG4105K59 histidine triad (HIT) protein Daes_3165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Daes_3167 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Daes_3168 ENOG4105E2X shikimate dehydrogenase Daes_3169 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Daes_3171 ENOG4108094 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Daes_3172 ENOG4105BZ1 (ABC) transporter Daes_3174 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Daes_3175 ENOG4105SYT Methylenetetrahydrofolate reductase Daes_3179 ENOG4107QY8 reductase Daes_3180 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Daes_3186 ENOG4105VPX protein, conserved in bacteria Daes_3187 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Daes_3188 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin Daes_3189 ENOG4105CFP Peptidase U32 Daes_3190 ENOG4107Y70 Heat shock protein Daes_3191 ENOG4105MYT Heat shock protein Daes_3192 ENOG4105W49 UPF0434 protein Daes_3193 ENOG4105DB7 PHP domain protein Daes_3195 ENOG4105CD3 dihydroorotase Daes_3196 ENOG4105CXT aspartate transcarbamylase Daes_3197 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Daes_3199 ENOG410681U heavy metal transport detoxification protein Daes_3200 ENOG4105WH1 Two component transcriptional regulator luxr family Daes_3203 ENOG4105W87 Cbs domain Daes_3204 ENOG4105E3W Two component transcriptional regulator (Winged helix family Daes_3214 ENOG4105DZS Phenylacetate-CoA ligase Daes_3227 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Daes_3235 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Daes_3236 ENOG4105DG7 nitrate ABC transporter Daes_3247 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Daes_3249 ENOG4108HR6 Dehydrogenase Daes_3250 ENOG4107QI1 Mate efflux family protein Daes_3256 ENOG4105EAU Plays a role in nitrite reduction (By similarity) Daes_3257 ENOG4108W6G cytochrome C Daes_3258 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Daes_3262 ENOG4105DN3 alpha-2-macroglobulin domain protein Daes_3263 ENOG4108JQB penicillin-binding protein 1C Daes_3264 ENOG4105BZU Histidine kinase Daes_3265 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Daes_3270 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Daes_3271 ENOG4105FAW cDP-glucose 4,6-dehydratase Daes_3272 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Daes_3275 ENOG4108IAJ Nad-dependent epimerase dehydratase Daes_3277 ENOG410600T transposase Daes_3282 ENOG4105D3R alkyl hydroperoxide reductase Daes_3285 ENOG4107YZX Universal stress protein Daes_3286 ENOG4105D3Q Sugar transferase Daes_3289 ENOG4105C8Q Methyl-accepting chemotaxis Daes_3290 ENOG4105EGS Mechanosensitive ion channel Daes_3291 ENOG4107XGZ Hydrolase Daes_3292 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Daes_3298 ENOG4105DTA methyltransferase Daes_3299 ENOG4105C0P Mg chelatase subunit ChlI Daes_3304 ENOG4105CN8 Transcriptional regulator Daes_3309 ENOG4105CAQ asparagine synthetase Daes_3314 ENOG4105CVJ phosphoglycerate mutase Daes_3315 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Daes_3316 ENOG4105BZU Histidine kinase Daes_3318 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Daes_3319 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Daes_3321 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Daes_3323 ENOG4105CM2 brancheD-chain amino acid aminotransferase Daes_3325 ENOG4105DDQ anthranilate synthase Daes_3326 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Daes_3327 ENOG4105C12 Phosphoribosylglycinamide synthetase Daes_3333 ENOG4105CMM transposase Daes_3336 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Daes_3341 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase