locus-tag	class	description
HWQ50_00030	COG0840	transmembrane signaling receptor activity
HWQ50_00040	COG1126	abc transporter atp-binding protein
HWQ50_00045	COG0765	amino acid transport
HWQ50_00075	COG1051	belongs to the nudix hydrolase family
HWQ50_00080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_00085	COG0251	oxidation-reduction process
HWQ50_00110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ50_00130	COG2986	histidine ammonia-lyase
HWQ50_00135	COG4175	Glycine betaine
HWQ50_00140	COG4176	ABC-type proline glycine betaine transport system permease component
HWQ50_00160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWQ50_00195	COG0402	S-adenosylhomocysteine deaminase activity
HWQ50_00245	COG0789	Transcriptional regulator
HWQ50_00250	COG1217	gtp-binding protein TYPA
HWQ50_00270	COG0668	transmembrane transport
HWQ50_00285	COG3852	Histidine kinase
HWQ50_00300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWQ50_00330	COG4942	peptidase
HWQ50_00335	COG0793	Belongs to the peptidase S41A family
HWQ50_00340	COG2861	carbohydrate metabolic process
HWQ50_00400	COG0579	oxidoreductase
HWQ50_00410	COG1194	a g-specific adenine glycosylase
HWQ50_00420	COG0673	inositol 2-dehydrogenase activity
HWQ50_00430	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_00465	COG1846	Transcriptional regulator
HWQ50_00475	COG1566	PFAM secretion protein HlyD family protein
HWQ50_00480	COG2814	Major facilitator Superfamily
HWQ50_00490	COG1088	dTDP-glucose 4,6-dehydratase activity
HWQ50_00495	COG1091	dTDP-4-dehydrorhamnose reductase activity
HWQ50_00575	COG1218	3'(2'),5'-bisphosphate nucleotidase
HWQ50_00580	COG0494	nUDIX hydrolase
HWQ50_00585	COG1011	Hydrolase
HWQ50_00590	COG1652	LysM domain
HWQ50_00600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWQ50_00620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HWQ50_00630	COG0824	Thioesterase
HWQ50_00635	COG1454	alcohol dehydrogenase
HWQ50_00640	COG1960	acyl-CoA dehydrogenase activity
HWQ50_00645	COG1024	Enoyl-CoA hydratase
HWQ50_00645	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ50_00655	COG0778	Nitroreductase
HWQ50_00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWQ50_00685	COG0189	ligase activity
HWQ50_00685	COG4067	protein conserved in archaea
HWQ50_00710	COG2183	response to ionizing radiation
HWQ50_00740	COG0306	phosphate transporter
HWQ50_00745	COG1392	Phosphate transport regulator
HWQ50_00750	COG3025	triphosphatase activity
HWQ50_00755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWQ50_00785	COG1178	ABC-type Fe3 transport system permease component
HWQ50_00795	COG0583	DNA-binding transcription factor activity
HWQ50_00810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ50_00820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ50_00825	COG0006	proline dipeptidase activity
HWQ50_00845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWQ50_00860	COG0842	Transport permease protein
HWQ50_00865	COG1129	ABC transporter
HWQ50_00865	COG0842	Transport permease protein
HWQ50_00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_00885	COG2271	Major facilitator Superfamily
HWQ50_00900	COG2755	lipolytic protein G-D-S-L family
HWQ50_00900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HWQ50_00915	COG0248	Ppx GppA phosphatase
HWQ50_00930	COG0586	Pfam SNARE associated Golgi protein
HWQ50_00935	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HWQ50_00940	COG2050	protein possibly involved in aromatic compounds catabolism
HWQ50_00950	COG0672	)-iron permease
HWQ50_00955	COG1280	lysine exporter protein (LysE YggA)
HWQ50_00960	COG0861	Integral membrane protein TerC family
HWQ50_00970	COG0488	(ABC) transporter
HWQ50_01025	COG3275	phosphorelay sensor kinase activity
HWQ50_01085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWQ50_01145	COG0432	Pfam Uncharacterised protein family UPF0047
HWQ50_01150	COG0004	ammonium transporteR
HWQ50_01155	COG0347	Belongs to the P(II) protein family
HWQ50_01165	COG0606	chelatase, subunit chli
HWQ50_01170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ50_01180	COG0583	DNA-binding transcription factor activity
HWQ50_01195	COG0210	DNA helicase
HWQ50_01200	COG0028	Belongs to the TPP enzyme family
HWQ50_01210	COG0427	acetyl-CoA hydrolase
HWQ50_01220	COG1917	Cupin 2, conserved barrel domain protein
HWQ50_01220	COG1396	sequence-specific DNA binding
HWQ50_01230	COG0251	oxidation-reduction process
HWQ50_01260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_01265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ50_01270	COG2814	Major facilitator Superfamily
HWQ50_01275	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_01280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWQ50_01300	COG0747	negative chemotaxis
HWQ50_01315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWQ50_01355	COG3245	cytochrome
HWQ50_01375	COG0708	Exodeoxyribonuclease III
HWQ50_01390	COG1561	YicC-like family, N-terminal region
HWQ50_01405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ50_01425	COG4753	response regulator
HWQ50_01425	COG2207	Transcriptional regulator
HWQ50_01435	COG0583	DNA-binding transcription factor activity
HWQ50_01440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWQ50_01475	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HWQ50_01480	COG0247	lactate metabolic process
HWQ50_01485	COG0277	FAD linked oxidase domain protein
HWQ50_01490	COG0277	FAD linked oxidase domain protein
HWQ50_01495	COG2186	Transcriptional regulator
HWQ50_01525	COG1253	flavin adenine dinucleotide binding
HWQ50_01530	COG0739	heme binding
HWQ50_01550	COG0573	inorganic phosphate transmembrane transporter activity
HWQ50_01590	COG0477	Major facilitator Superfamily
HWQ50_01595	COG1607	acyl-coa hydrolase
HWQ50_01615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ50_01620	COG4175	Glycine betaine
HWQ50_01625	COG4176	ABC-type proline glycine betaine transport system permease component
HWQ50_01635	COG1760	l-serine dehydratase
HWQ50_01650	COG0583	DNA-binding transcription factor activity
HWQ50_01660	COG0657	acetylesterase activity
HWQ50_01675	COG3246	L-lysine catabolic process to acetate
HWQ50_01730	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ50_01730	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_01735	COG0247	lactate metabolic process
HWQ50_01735	COG2181	nitrate reductase activity
HWQ50_01755	COG3655	Transcriptional regulator
HWQ50_01800	COG1017	nitric oxide dioxygenase activity
HWQ50_01800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ50_01885	COG0583	DNA-binding transcription factor activity
HWQ50_01895	COG2391	methyltransferase activity
HWQ50_01920	COG0511	ligase activity, forming carbon-carbon bonds
HWQ50_01920	COG5016	pyruvate
HWQ50_01925	COG0439	Biotin carboxylase
HWQ50_01930	COG0583	DNA-binding transcription factor activity
HWQ50_01945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HWQ50_01950	COG0826	peptidase U32
HWQ50_01970	COG0210	DNA helicase
HWQ50_01980	COG0427	acetyl-CoA hydrolase
HWQ50_01995	COG0438	transferase activity, transferring glycosyl groups
HWQ50_02040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWQ50_02045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HWQ50_02045	COG2755	lipolytic protein G-D-S-L family
HWQ50_02085	COG0679	Auxin Efflux Carrier
HWQ50_02095	COG2851	Citrate transporter
HWQ50_02100	COG0861	Integral membrane protein TerC family
HWQ50_02105	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HWQ50_02110	COG1690	Belongs to the RtcB family
HWQ50_02145	COG0700	Nucleoside recognition
HWQ50_02150	COG1301	dicarboxylic acid transport
HWQ50_02170	COG5002	protein histidine kinase activity
HWQ50_02175	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWQ50_02180	COG2095	MarC family integral membrane protein
HWQ50_02205	COG3245	cytochrome
HWQ50_02240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HWQ50_02245	COG0735	belongs to the Fur family
HWQ50_02255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWQ50_02270	COG2011	ABC-type metal ion transport system permease component
HWQ50_02300	COG0531	amino acid
HWQ50_02310	COG4191	Histidine kinase
HWQ50_02340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ50_02340	COG4651	solute:proton antiporter activity
HWQ50_02345	COG1607	acyl-coa hydrolase
HWQ50_02355	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_02360	COG0174	glutamine synthetase
HWQ50_02365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWQ50_02370	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_02395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ50_02395	COG4651	solute:proton antiporter activity
HWQ50_02400	COG0477	Major facilitator Superfamily
HWQ50_02410	COG0523	cobalamin synthesis protein
HWQ50_02455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWQ50_02475	COG2358	TRAP transporter, solute receptor (TAXI family
HWQ50_02480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWQ50_02500	COG1349	DNA-binding transcription factor activity
HWQ50_02560	COG1475	DNA binding
HWQ50_02565	COG1192	Involved in chromosome partitioning
HWQ50_02635	COG2010	Cytochrome c
HWQ50_02650	COG2818	Glycosylase
HWQ50_02665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HWQ50_02680	COG0569	domain protein
HWQ50_02700	COG1652	LysM domain
HWQ50_02705	COG0758	DNA mediated transformation
HWQ50_02735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ50_02755	COG3119	arylsulfatase activity
HWQ50_02760	COG0583	DNA-binding transcription factor activity
HWQ50_02795	COG3360	Dodecin
HWQ50_02830	COG3174	membrane
HWQ50_02875	COG0367	asparagine synthase
HWQ50_02905	COG0583	DNA-binding transcription factor activity
HWQ50_02920	COG1764	response to oxidative stress
HWQ50_02955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWQ50_02960	COG0339	signal peptide processing
HWQ50_02965	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HWQ50_02980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWQ50_02995	COG0515	serine threonine protein kinase
HWQ50_02995	COG2815	serine threonine protein kinase
HWQ50_03000	COG0631	protein serine/threonine phosphatase activity
HWQ50_03015	COG1360	Flagellar Motor Protein
HWQ50_03140	COG0659	secondary active sulfate transmembrane transporter activity
HWQ50_03150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWQ50_03155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWQ50_03160	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HWQ50_03200	COG2153	protein acetylation
HWQ50_03240	COG0583	DNA-binding transcription factor activity
HWQ50_03265	COG2824	Alkylphosphonate utilization operon protein PhnA
HWQ50_03295	COG0402	S-adenosylhomocysteine deaminase activity
HWQ50_03305	COG3845	ABC transporter
HWQ50_03310	COG4603	Belongs to the binding-protein-dependent transport system permease family
HWQ50_03315	COG1079	Belongs to the binding-protein-dependent transport system permease family
HWQ50_03390	COG0583	DNA-binding transcription factor activity
HWQ50_03395	COG3485	protocatechuate 3,4-dioxygenase
HWQ50_03400	COG3485	protocatechuate 3,4-dioxygenase
HWQ50_03405	COG1414	Transcriptional regulator
HWQ50_03420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_03425	COG0583	DNA-binding transcription factor activity
HWQ50_03455	COG2233	PERMEase
HWQ50_03460	COG1309	transcriptional regulator
HWQ50_03495	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HWQ50_03510	COG0835	chemotaxis
HWQ50_03515	COG2198	Histidine kinase
HWQ50_03515	COG0643	Histidine kinase
HWQ50_03520	COG0745	RESPONSE REGULATOR receiver
HWQ50_03530	COG0583	DNA-binding transcription factor activity
HWQ50_03535	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_03545	COG1116	anion transmembrane transporter activity
HWQ50_03550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ50_03555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_03595	COG2175	clavaminate synthase activity
HWQ50_03670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWQ50_03695	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_03700	COG1113	amino acid transport
HWQ50_03715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ50_03720	COG0235	Class ii aldolase
HWQ50_03725	COG1396	sequence-specific DNA binding
HWQ50_03730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ50_03735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ50_03745	COG0477	Major facilitator Superfamily
HWQ50_03755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ50_03760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ50_03765	COG0583	DNA-binding transcription factor activity
HWQ50_03785	COG0673	inositol 2-dehydrogenase activity
HWQ50_03805	COG2271	Major facilitator Superfamily
HWQ50_03815	COG1309	transcriptional regulator
HWQ50_03820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWQ50_03830	COG0477	Major facilitator Superfamily
HWQ50_03850	COG2239	Acts as a magnesium transporter
HWQ50_03885	COG2801	Transposase and inactivated derivatives
HWQ50_03950	COG0745	RESPONSE REGULATOR receiver
HWQ50_03960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ50_03975	COG0583	DNA-binding transcription factor activity
HWQ50_03980	COG2807	transmembrane transport
HWQ50_04000	COG0501	Belongs to the peptidase M48B family
HWQ50_04020	COG4208	sulfate ABC transporter
HWQ50_04030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWQ50_04050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ50_04065	COG2199	diguanylate cyclase activity
HWQ50_04090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HWQ50_04095	COG0174	glutamine synthetase
HWQ50_04100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HWQ50_04105	COG0174	glutamine synthetase
HWQ50_04125	COG3842	ATPase activity
HWQ50_04130	COG1176	ABC-type spermidine putrescine transport system, permease component I
HWQ50_04135	COG1177	transmembrane transport
HWQ50_04190	COG0765	amino acid transport
HWQ50_04205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWQ50_04210	COG0277	FAD linked oxidase domain protein
HWQ50_04215	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWQ50_04225	COG3111	PFAM Bacterial OB fold (BOF) protein
HWQ50_04235	COG0531	amino acid
HWQ50_04240	COG2182	Extracellular solute-binding protein
HWQ50_04245	COG1177	transmembrane transport
HWQ50_04255	COG3842	ATPase activity
HWQ50_04260	COG3204	pilus organization
HWQ50_04265	COG2234	aminopeptidase activity
HWQ50_04285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWQ50_04295	COG0702	epimerase
HWQ50_04335	COG0730	response to heat
HWQ50_04370	COG0584	glycerophosphoryl diester phosphodiesterase
HWQ50_04390	COG0622	Phosphoesterase
HWQ50_04395	COG2233	PERMEase
HWQ50_04410	COG0693	protein deglycase activity
HWQ50_04445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ50_04455	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HWQ50_04480	COG0429	hydrolase of the alpha beta-hydrolase fold
HWQ50_04490	COG0742	ribosomal rna small subunit methyltransferase
HWQ50_04495	COG0612	Peptidase, M16
HWQ50_04500	COG0612	Peptidase, M16
HWQ50_04505	COG0552	protein localization to endoplasmic reticulum
HWQ50_04510	COG2884	Cell division ATP-binding protein ftsE
HWQ50_04515	COG2177	Part of the ABC transporter FtsEX involved in
HWQ50_04535	COG2363	Small membrane protein
HWQ50_04570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWQ50_04585	COG2813	Specifically methylates the guanine in position
HWQ50_04585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ50_04595	COG1160	GTP binding
HWQ50_04600	COG1872	DUF167
HWQ50_04645	COG0626	cystathionine gamma-synthase activity
HWQ50_04710	COG0784	Response regulator, receiver
HWQ50_04710	COG0643	Histidine kinase
HWQ50_04710	COG2198	Histidine kinase
HWQ50_04740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWQ50_04755	COG3038	cytochrome b561
HWQ50_04785	COG0513	Belongs to the DEAD box helicase family
HWQ50_04795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWQ50_04800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ50_04825	COG1309	transcriptional regulator
HWQ50_04830	COG0402	S-adenosylhomocysteine deaminase activity
HWQ50_04835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWQ50_04845	COG0493	'glutamate synthase
HWQ50_04855	COG1953	Uracil, thiamine, allantoin
HWQ50_04870	COG1960	acyl-CoA dehydrogenase activity
HWQ50_04875	COG0583	DNA-binding transcription factor activity
HWQ50_04885	COG0306	phosphate transporter
HWQ50_04895	COG0330	HflC and HflK could
HWQ50_04905	COG1289	transmembrane transporter activity
HWQ50_04910	COG0513	Belongs to the DEAD box helicase family
HWQ50_04920	COG0189	ligase activity
HWQ50_04920	COG4067	protein conserved in archaea
HWQ50_04930	COG0477	Major facilitator Superfamily
HWQ50_04935	COG0542	response to heat
HWQ50_04945	COG0204	Acyl-transferase
HWQ50_04955	COG0745	RESPONSE REGULATOR receiver
HWQ50_04960	COG2205	protein histidine kinase activity
HWQ50_04965	COG4452	Inner membrane protein CreD
HWQ50_04995	COG4774	siderophore transport
HWQ50_05000	COG3712	iron ion homeostasis
HWQ50_05005	COG1595	DNA-templated transcription, initiation
HWQ50_05010	COG0625	glutathione transferase activity
HWQ50_05020	COG1309	transcriptional regulator
HWQ50_05025	COG1953	Uracil, thiamine, allantoin
HWQ50_05045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ50_05080	COG2005	Transcriptional regulator
HWQ50_05080	COG3585	molybdate ion transport
HWQ50_05085	COG5544	Lipoprotein
HWQ50_05090	COG1040	competence protein
HWQ50_05110	COG0511	ligase activity, forming carbon-carbon bonds
HWQ50_05125	COG1984	allophanate hydrolase subunit 2
HWQ50_05135	COG3121	Chaperone
HWQ50_05150	COG1073	alpha beta
HWQ50_05150	COG2226	methyltransferase
HWQ50_05170	COG1960	acyl-CoA dehydrogenase activity
HWQ50_05175	COG1960	acyl-CoA dehydrogenase activity
HWQ50_05180	COG1960	acyl-CoA dehydrogenase activity
HWQ50_05190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWQ50_05190	COG1648	precorrin-2 dehydrogenase activity
HWQ50_05275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWQ50_05280	COG0583	DNA-binding transcription factor activity
HWQ50_05285	COG2258	MOSC domain
HWQ50_05295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWQ50_05315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_05325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWQ50_05380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWQ50_05385	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWQ50_05395	COG3622	Belongs to the hyi family
HWQ50_05400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWQ50_05440	COG2081	HI0933 family
HWQ50_05445	COG1451	nucleotide metabolic process
HWQ50_05455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWQ50_05460	COG3152	Membrane
HWQ50_05465	COG4977	sequence-specific DNA binding
HWQ50_05465	COG1917	Cupin 2, conserved barrel domain protein
HWQ50_05470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ50_05565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWQ50_05585	COG2719	SpoVR family
HWQ50_05595	COG2766	serine protein kinase
HWQ50_05645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HWQ50_05660	COG2197	response regulator
HWQ50_05670	COG3842	ATPase activity
HWQ50_05680	COG1176	ABC-type spermidine putrescine transport system, permease component I
HWQ50_05690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWQ50_05720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWQ50_05805	COG3179	chitinase
HWQ50_05840	COG1765	OsmC-like protein
HWQ50_05855	COG0537	adenosine 5'-monophosphoramidase activity
HWQ50_05880	COG1981	membrane
HWQ50_05910	COG0739	heme binding
HWQ50_06075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HWQ50_06200	COG2814	Major facilitator Superfamily
HWQ50_06225	COG1021	2,3-dihydroxybenzoate-AMP ligase
HWQ50_06235	COG2226	methyltransferase
HWQ50_06235	COG3433	isochorismatase activity
HWQ50_06235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ50_06240	COG3433	isochorismatase activity
HWQ50_06240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ50_06240	COG2226	methyltransferase
HWQ50_06250	COG1132	(ABC) transporter
HWQ50_06250	COG2375	cellular response to nickel ion
HWQ50_06335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_06350	COG2706	6-phosphogluconolactonase activity
HWQ50_06370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ50_06375	COG1960	acyl-CoA dehydrogenase activity
HWQ50_06385	COG4191	Histidine kinase
HWQ50_06390	COG4566	intracellular signal transduction
HWQ50_06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_06400	COG0765	amino acid transport
HWQ50_06405	COG0765	amino acid transport
HWQ50_06425	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_06430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ50_06435	COG2271	Major facilitator Superfamily
HWQ50_06480	COG2226	methyltransferase
HWQ50_06490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ50_06505	COG0251	oxidation-reduction process
HWQ50_06515	COG0693	protein deglycase activity
HWQ50_06520	COG0492	ferredoxin-NADP+ reductase activity
HWQ50_06525	COG1959	2 iron, 2 sulfur cluster binding
HWQ50_06555	COG0154	amidase activity
HWQ50_06575	COG0583	DNA-binding transcription factor activity
HWQ50_06580	COG2814	Major facilitator Superfamily
HWQ50_06585	COG0583	DNA-binding transcription factor activity
HWQ50_06590	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_06595	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWQ50_06600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWQ50_06605	COG4592	Periplasmic binding protein
HWQ50_06610	COG1120	ATPase activity
HWQ50_06620	COG1629	transport
HWQ50_06620	COG4774	siderophore transport
HWQ50_06625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ50_06630	COG4991	sh3 domain protein
HWQ50_06635	COG1063	alcohol dehydrogenase
HWQ50_06645	COG0022	dehydrogenase e1 component
HWQ50_06650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWQ50_06655	COG3199	ATP-NAD kinase
HWQ50_06665	COG3284	Transcriptional regulator
HWQ50_06690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_06720	COG2814	Major facilitator Superfamily
HWQ50_06725	COG1846	Transcriptional regulator
HWQ50_06735	COG3278	Belongs to the heme-copper respiratory oxidase family
HWQ50_06740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ50_06750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ50_06765	COG3971	2-oxopent-4-enoate hydratase activity
HWQ50_06770	COG2271	Major facilitator Superfamily
HWQ50_06780	COG3384	dioxygenase
HWQ50_06785	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_06825	COG1611	Belongs to the LOG family
HWQ50_06885	COG2259	Doxx family
HWQ50_06895	COG2205	protein histidine kinase activity
HWQ50_06920	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_06925	COG1063	alcohol dehydrogenase
HWQ50_06930	COG2271	Major facilitator Superfamily
HWQ50_06965	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_06970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWQ50_06985	COG3121	Chaperone
HWQ50_06990	COG3188	usher protein
HWQ50_07000	COG3210	domain, Protein
HWQ50_07010	COG2197	response regulator
HWQ50_07050	COG0531	amino acid
HWQ50_07070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWQ50_07080	COG3047	cAMP biosynthetic process
HWQ50_07110	COG3118	belongs to the thioredoxin family
HWQ50_07115	COG2264	protein methyltransferase activity
HWQ50_07130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWQ50_07130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWQ50_07155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWQ50_07160	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWQ50_07170	COG3577	Aspartyl protease
HWQ50_07185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWQ50_07195	COG0142	geranyltranstransferase activity
HWQ50_07205	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ50_07295	COG1131	(ABC) transporter
HWQ50_07300	COG5002	protein histidine kinase activity
HWQ50_07320	COG0745	RESPONSE REGULATOR receiver
HWQ50_07330	COG3228	Belongs to the MtfA family
HWQ50_07335	COG0586	Pfam SNARE associated Golgi protein
HWQ50_07350	COG0456	acetyltransferase
HWQ50_07360	COG4303	Ethanolamine ammonia lyase large subunit
HWQ50_07365	COG0531	amino acid
HWQ50_07375	COG3284	Transcriptional regulator
HWQ50_07380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWQ50_07395	COG0702	epimerase
HWQ50_07415	COG1346	cytolysis
HWQ50_07425	COG0586	Pfam SNARE associated Golgi protein
HWQ50_07465	COG0768	penicillin binding
HWQ50_07470	COG0772	Belongs to the SEDS family
HWQ50_07475	COG2951	lytic endotransglycosylase activity
HWQ50_07485	COG1686	Belongs to the peptidase S11 family
HWQ50_07515	COG2951	lytic endotransglycosylase activity
HWQ50_07545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HWQ50_07555	COG4535	Mg2 and Co2 transporter CorC
HWQ50_07565	COG1702	phosphate starvation-inducible protein PhoH
HWQ50_07595	COG0351	phosphomethylpyrimidine kinase
HWQ50_07600	COG2205	protein histidine kinase activity
HWQ50_07600	COG2198	Histidine kinase
HWQ50_07600	COG0784	Response regulator, receiver
HWQ50_07610	COG1960	acyl-CoA dehydrogenase activity
HWQ50_07620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWQ50_07660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWQ50_07670	COG1643	Atp-dependent helicase
HWQ50_07715	COG3416	Protein conserved in bacteria
HWQ50_07725	COG0513	Belongs to the DEAD box helicase family
HWQ50_07735	COG2197	response regulator
HWQ50_07740	COG2202	Pas domain
HWQ50_07740	COG2200	EAL domain
HWQ50_07740	COG2199	diguanylate cyclase activity
HWQ50_07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_07745	COG2205	protein histidine kinase activity
HWQ50_07765	COG1946	Acyl-CoA thioesterase
HWQ50_07785	COG4521	taurine ABC transporter
HWQ50_07795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ50_07800	COG2175	clavaminate synthase activity
HWQ50_07805	COG1297	OPT oligopeptide transporter protein
HWQ50_07810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ50_07825	COG1271	oxidase subunit
HWQ50_07830	COG1294	oxidase, subunit
HWQ50_07840	COG2207	Transcriptional regulator
HWQ50_07850	COG0183	Belongs to the thiolase family
HWQ50_07855	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_07880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWQ50_07890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HWQ50_07900	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWQ50_07905	COG0303	'Molybdopterin
HWQ50_07910	COG0826	peptidase U32
HWQ50_07915	COG0826	peptidase U32
HWQ50_07920	COG3154	lipid carrier protein
HWQ50_07970	COG4772	TonB-dependent receptor
HWQ50_07975	COG3712	iron ion homeostasis
HWQ50_07980	COG1595	DNA-templated transcription, initiation
HWQ50_07990	COG0697	spore germination
HWQ50_08000	COG0583	DNA-binding transcription factor activity
HWQ50_08020	COG1566	PFAM secretion protein HlyD family protein
HWQ50_08075	COG0300	oxidoreductase activity
HWQ50_08080	COG2226	methyltransferase
HWQ50_08095	COG2197	response regulator
HWQ50_08100	COG3850	Histidine kinase
HWQ50_08110	COG2223	nitrite transmembrane transporter activity
HWQ50_08115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HWQ50_08120	COG1140	nitrate reductase beta subunit
HWQ50_08125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HWQ50_08130	COG2181	nitrate reductase activity
HWQ50_08135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ50_08145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_08170	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_08180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_08245	COG0583	DNA-binding transcription factor activity
HWQ50_08275	COG0471	metal ion transport
HWQ50_08275	COG0490	domain, Protein
HWQ50_08280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HWQ50_08285	COG4120	Belongs to the binding-protein-dependent transport system permease family
HWQ50_08330	COG0795	lipopolysaccharide-transporting ATPase activity
HWQ50_08335	COG0795	lipopolysaccharide-transporting ATPase activity
HWQ50_08345	COG2200	EAL domain
HWQ50_08390	COG1862	Preprotein translocase
HWQ50_08405	COG3134	Outer membrane lipoprotein
HWQ50_08420	COG1045	serine acetyltransferase
HWQ50_08510	COG0436	Aminotransferase
HWQ50_08525	COG0667	Aldo Keto reductase
HWQ50_08550	COG4771	TonB-dependent receptor
HWQ50_08565	COG0739	heme binding
HWQ50_08575	COG2847	Copper chaperone PCu(A)C
HWQ50_08600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HWQ50_08610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HWQ50_08615	COG0583	DNA-binding transcription factor activity
HWQ50_08670	COG0738	Major facilitator superfamily
HWQ50_08680	COG2130	NADP-dependent
HWQ50_08685	COG2132	Multicopper oxidase
HWQ50_08690	COG0590	tRNA wobble adenosine to inosine editing
HWQ50_08725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWQ50_08725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWQ50_08730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWQ50_08735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HWQ50_08740	COG2188	Transcriptional regulator
HWQ50_08780	COG0477	Major facilitator Superfamily
HWQ50_08785	COG4536	flavin adenine dinucleotide binding
HWQ50_08795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWQ50_08820	COG1607	acyl-coa hydrolase
HWQ50_08840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ50_08865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWQ50_08905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWQ50_08915	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_08955	COG2197	response regulator
HWQ50_08960	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HWQ50_08980	COG0477	Major facilitator Superfamily
HWQ50_09015	COG5001	Diguanylate cyclase
HWQ50_09015	COG2203	Gaf domain
HWQ50_09015	COG4251	negative regulation of phosphorylation
HWQ50_09015	COG3706	GGDEF domain
HWQ50_09020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HWQ50_09050	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HWQ50_09050	COG1073	alpha beta
HWQ50_09050	COG3064	Membrane
HWQ50_09065	COG2885	chlorophyll binding
HWQ50_09080	COG0789	Transcriptional regulator
HWQ50_09100	COG1214	PFAM Peptidase M22, glycoprotease
HWQ50_09110	COG1801	Protein of unknown function DUF72
HWQ50_09115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HWQ50_09140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_09185	COG2166	iron-sulfur cluster assembly
HWQ50_09205	COG1393	Belongs to the ArsC family
HWQ50_09225	COG0025	NhaP-type Na H and K H
HWQ50_09230	COG0436	Aminotransferase
HWQ50_09240	COG0024	Methionine aminopeptidase
HWQ50_09285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWQ50_09320	COG1115	amino acid carrier protein
HWQ50_09370	COG2391	methyltransferase activity
HWQ50_09375	COG0583	DNA-binding transcription factor activity
HWQ50_09380	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWQ50_09385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HWQ50_09435	COG1546	Belongs to the CinA family
HWQ50_09455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HWQ50_09460	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HWQ50_09465	COG3530	Putative quorum-sensing-regulated virulence factor
HWQ50_09480	COG1177	transmembrane transport
HWQ50_09485	COG1176	ABC-type spermidine putrescine transport system, permease component I
HWQ50_09495	COG3148	PFAM DTW domain containing protein
HWQ50_09515	COG0069	glutamate synthase activity
HWQ50_09540	COG0531	amino acid
HWQ50_09545	COG2169	Transcriptional regulator
HWQ50_09545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ50_09550	COG0477	Major facilitator Superfamily
HWQ50_09555	COG0583	DNA-binding transcription factor activity
HWQ50_09560	COG1960	acyl-CoA dehydrogenase activity
HWQ50_09565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWQ50_09570	COG1024	Enoyl-CoA hydratase
HWQ50_09575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ50_09580	COG0183	Belongs to the thiolase family
HWQ50_09590	COG0583	DNA-binding transcription factor activity
HWQ50_09625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWQ50_09665	COG2814	Major facilitator Superfamily
HWQ50_09705	COG0583	DNA-binding transcription factor activity
HWQ50_09725	COG0084	hydrolase, TatD family'
HWQ50_09730	COG1609	Transcriptional regulator
HWQ50_09740	COG1105	Belongs to the carbohydrate kinase PfkB family
HWQ50_09745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWQ50_09745	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HWQ50_09745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWQ50_09855	COG3842	ATPase activity
HWQ50_09875	COG0243	molybdopterin cofactor binding
HWQ50_09880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HWQ50_09885	COG2223	nitrite transmembrane transporter activity
HWQ50_09900	COG0450	alkyl hydroperoxide reductase
HWQ50_09930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_09965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWQ50_09970	COG2264	protein methyltransferase activity
HWQ50_09980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWQ50_10050	COG0489	protein tyrosine kinase activity
HWQ50_10095	COG0791	NLP P60 protein
HWQ50_10110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWQ50_10115	COG0668	transmembrane transport
HWQ50_10120	COG0477	Major facilitator Superfamily
HWQ50_10125	COG0513	Belongs to the DEAD box helicase family
HWQ50_10145	COG0784	Response regulator, receiver
HWQ50_10145	COG2205	protein histidine kinase activity
HWQ50_10145	COG5002	protein histidine kinase activity
HWQ50_10150	COG1363	Peptidase, m42
HWQ50_10155	COG0189	ligase activity
HWQ50_10155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWQ50_10160	COG0367	asparagine synthase
HWQ50_10185	COG0183	Belongs to the thiolase family
HWQ50_10205	COG0450	alkyl hydroperoxide reductase
HWQ50_10210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_10215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ50_10225	COG0431	NADPH-dependent FMN reductase
HWQ50_10230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_10240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ50_10265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWQ50_10290	COG0583	DNA-binding transcription factor activity
HWQ50_10295	COG1380	Effector of murein hydrolase LrgA
HWQ50_10300	COG1346	cytolysis
HWQ50_10320	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_10325	COG1024	Enoyl-CoA hydratase
HWQ50_10335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HWQ50_10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWQ50_10420	COG1629	transport
HWQ50_10475	COG0583	DNA-binding transcription factor activity
HWQ50_10550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HWQ50_10555	COG3639	organic phosphonate transmembrane transporter activity
HWQ50_10560	COG2188	Transcriptional regulator
HWQ50_10565	COG3624	Phosphonate C-P lyase system protein PhnG
HWQ50_10575	COG3626	phosphonate metabolism
HWQ50_10580	COG3627	carbon phosphorus lyase activity
HWQ50_10585	COG4107	phosphonate C-P lyase system protein PhnK
HWQ50_10590	COG4778	phosphonate C-P lyase system protein PhnL
HWQ50_10595	COG3454	Phosphonate metabolism
HWQ50_10605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HWQ50_10695	COG0697	spore germination
HWQ50_10720	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HWQ50_10740	COG0784	Response regulator, receiver
HWQ50_10740	COG0835	chemotaxis
HWQ50_10755	COG0745	RESPONSE REGULATOR receiver
HWQ50_10765	COG0514	ATP-dependent DNA helicase (RecQ)
HWQ50_10770	COG4251	negative regulation of phosphorylation
HWQ50_10770	COG5001	Diguanylate cyclase
HWQ50_10770	COG2203	Gaf domain
HWQ50_10770	COG3706	GGDEF domain
HWQ50_10790	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWQ50_10830	COG2124	cytochrome p450
HWQ50_10835	COG4221	oxidoreductase activity
HWQ50_10880	COG0583	DNA-binding transcription factor activity
HWQ50_10910	COG3639	organic phosphonate transmembrane transporter activity
HWQ50_10920	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HWQ50_10925	COG2084	Dehydrogenase
HWQ50_10940	COG0589	response to stress
HWQ50_10985	COG2814	Major facilitator Superfamily
HWQ50_10990	COG2030	dehydratase
HWQ50_10995	COG2267	carboxylic ester hydrolase activity
HWQ50_11000	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_11005	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_11015	COG1643	Atp-dependent helicase
HWQ50_11025	COG0537	adenosine 5'-monophosphoramidase activity
HWQ50_11065	COG1595	DNA-templated transcription, initiation
HWQ50_11135	COG1201	RNA secondary structure unwinding
HWQ50_11140	COG0784	Response regulator, receiver
HWQ50_11140	COG2205	protein histidine kinase activity
HWQ50_11155	COG4772	TonB-dependent receptor
HWQ50_11170	COG2076	Multidrug Resistance protein
HWQ50_11175	COG0385	Bile acid
HWQ50_11225	COG2200	EAL domain
HWQ50_11235	COG3321	synthase
HWQ50_11235	COG0604	alcohol dehydrogenase
HWQ50_11240	COG0560	Phosphoserine phosphatase
HWQ50_11255	COG1176	ABC-type spermidine putrescine transport system, permease component I
HWQ50_11285	COG0564	pseudouridine synthase activity
HWQ50_11295	COG2894	cell division
HWQ50_11305	COG1560	Kdo2-lipid A biosynthetic process
HWQ50_11320	COG2853	Lipoprotein
HWQ50_11340	COG3162	membrane
HWQ50_11345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ50_11375	COG1132	(ABC) transporter
HWQ50_11385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ50_11410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ50_11425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWQ50_11425	COG0438	transferase activity, transferring glycosyl groups
HWQ50_11455	COG1127	ABC transporter
HWQ50_11460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWQ50_11465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWQ50_11470	COG0727	PFAM Uncharacterised protein family (UPF0153)
HWQ50_11475	COG0778	Nitroreductase
HWQ50_11495	COG0745	RESPONSE REGULATOR receiver
HWQ50_11505	COG2350	Protein conserved in bacteria
HWQ50_11515	COG0613	PHP domain protein
HWQ50_11520	COG0009	L-threonylcarbamoyladenylate synthase
HWQ50_11530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWQ50_11575	COG1175	transmembrane transport
HWQ50_11580	COG0395	ABC-type sugar transport system, permease component
HWQ50_11585	COG3842	ATPase activity
HWQ50_11595	COG0676	glucose-6-phosphate 1-epimerase activity
HWQ50_11640	COG0786	glutamate:sodium symporter activity
HWQ50_11655	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_11670	COG0402	S-adenosylhomocysteine deaminase activity
HWQ50_11700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWQ50_11740	COG1086	Polysaccharide biosynthesis protein
HWQ50_11765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWQ50_11805	COG0583	DNA-binding transcription factor activity
HWQ50_11840	COG0596	Alpha beta hydrolase
HWQ50_11845	COG0800	Aldolase
HWQ50_11860	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_11880	COG0583	DNA-binding transcription factor activity
HWQ50_11885	COG0251	oxidation-reduction process
HWQ50_11905	COG2226	methyltransferase
HWQ50_11945	COG0285	dihydrofolate synthase activity
HWQ50_11950	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWQ50_11955	COG1286	toxin biosynthetic process
HWQ50_12055	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_12055	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ50_12080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWQ50_12090	COG3139	Protein of unknown function (DUF1315)
HWQ50_12100	COG0308	aminopeptidase N
HWQ50_12130	COG0745	RESPONSE REGULATOR receiver
HWQ50_12165	COG0714	Associated with various cellular activities
HWQ50_12185	COG1335	isochorismatase
HWQ50_12195	COG2342	PFAM TM1410 hypothetical-related protein
HWQ50_12220	COG0297	glycogen (starch) synthase activity
HWQ50_12275	COG2027	D-alanyl-D-alanine carboxypeptidase
HWQ50_12280	COG3171	Protein conserved in bacteria
HWQ50_12285	COG2197	response regulator
HWQ50_12290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_12290	COG2205	protein histidine kinase activity
HWQ50_12315	COG0004	ammonium transporteR
HWQ50_12325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ50_12335	COG0625	glutathione transferase activity
HWQ50_12340	COG1309	transcriptional regulator
HWQ50_12370	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWQ50_12390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWQ50_12395	COG1070	Carbohydrate kinase
HWQ50_12415	COG0741	lytic transglycosylase activity
HWQ50_12420	COG0488	(ABC) transporter
HWQ50_12430	COG0589	response to stress
HWQ50_12505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWQ50_12515	COG1113	amino acid transport
HWQ50_12550	COG1477	protein flavinylation
HWQ50_12565	COG0584	glycerophosphoryl diester phosphodiesterase
HWQ50_12580	COG4591	ABC-type transport system involved in lipoprotein release permease component
HWQ50_12600	COG0658	competence protein
HWQ50_12600	COG2333	competence protein COMEC
HWQ50_12605	COG0811	peptide transport
HWQ50_12610	COG0848	biopolymer transport protein
HWQ50_12630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWQ50_12640	COG1530	ribonuclease E activity
HWQ50_12650	COG0546	phosphoglycolate phosphatase activity
HWQ50_12655	COG0616	signal peptide processing
HWQ50_12655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWQ50_12665	COG1399	metal-binding, possibly nucleic acid-binding protein
HWQ50_12695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWQ50_12705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWQ50_12725	COG0084	hydrolase, TatD family'
HWQ50_12810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HWQ50_12825	COG0183	Belongs to the thiolase family
HWQ50_12835	COG2233	PERMEase
HWQ50_12865	COG2814	Major facilitator Superfamily
HWQ50_12870	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_12875	COG1309	transcriptional regulator
HWQ50_12905	COG4160	amino acid transport
HWQ50_12910	COG4215	(ABC) transporter
HWQ50_12915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_12920	COG1473	amidohydrolase
HWQ50_12925	COG0583	DNA-binding transcription factor activity
HWQ50_12930	COG0840	transmembrane signaling receptor activity
HWQ50_12960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWQ50_12970	COG1120	ATPase activity
HWQ50_13000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ50_13030	COG2885	chlorophyll binding
HWQ50_13030	COG3047	cAMP biosynthetic process
HWQ50_13035	COG2197	response regulator
HWQ50_13045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ50_13050	COG1595	DNA-templated transcription, initiation
HWQ50_13065	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_13080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HWQ50_13085	COG1960	acyl-CoA dehydrogenase activity
HWQ50_13090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWQ50_13105	COG1309	transcriptional regulator
HWQ50_13135	COG0583	DNA-binding transcription factor activity
HWQ50_13145	COG0583	DNA-binding transcription factor activity
HWQ50_13155	COG0714	Associated with various cellular activities
HWQ50_13200	COG0084	hydrolase, TatD family'
HWQ50_13210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HWQ50_13215	COG2259	Doxx family
HWQ50_13230	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HWQ50_13245	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HWQ50_13250	COG4181	ATPase activity
HWQ50_13285	COG1764	response to oxidative stress
HWQ50_13290	COG1846	Transcriptional regulator
HWQ50_13295	COG0583	DNA-binding transcription factor activity
HWQ50_13305	COG0583	DNA-binding transcription factor activity
HWQ50_13315	COG3214	Protein conserved in bacteria
HWQ50_13320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HWQ50_13330	COG1024	Enoyl-CoA hydratase
HWQ50_13340	COG3384	dioxygenase
HWQ50_13380	COG2866	Carboxypeptidase
HWQ50_13395	COG0436	Aminotransferase
HWQ50_13405	COG0386	Belongs to the glutathione peroxidase family
HWQ50_13410	COG1846	Transcriptional regulator
HWQ50_13415	COG0784	Response regulator, receiver
HWQ50_13415	COG2205	protein histidine kinase activity
HWQ50_13415	COG5002	protein histidine kinase activity
HWQ50_13420	COG2255	four-way junction helicase activity
HWQ50_13425	COG1956	GAF domain-containing protein
HWQ50_13430	COG0625	glutathione transferase activity
HWQ50_13525	COG0625	glutathione transferase activity
HWQ50_13530	COG1131	(ABC) transporter
HWQ50_13535	COG0842	Transport permease protein
HWQ50_13580	COG2188	Transcriptional regulator
HWQ50_13590	COG2853	Lipoprotein
HWQ50_13600	COG0745	RESPONSE REGULATOR receiver
HWQ50_13660	COG1403	HNH endonuclease
HWQ50_13690	COG0419	ATPase involved in DNA repair
HWQ50_13695	COG1674	ftsk spoiiie
HWQ50_13705	COG3723	Recombinational DNA repair protein, rece pathway
HWQ50_13730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HWQ50_13910	COG3179	chitinase
HWQ50_13940	COG1335	isochorismatase
HWQ50_14000	COG3655	Transcriptional regulator
HWQ50_14040	COG2116	formate transmembrane transporter activity
HWQ50_14045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_14095	COG1051	belongs to the nudix hydrolase family
HWQ50_14105	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ50_14105	COG1024	Enoyl-CoA hydratase
HWQ50_14120	COG2837	iron assimilation
HWQ50_14205	COG1238	metal cluster binding
HWQ50_14215	COG1295	ribonuclease BN
HWQ50_14245	COG0024	Methionine aminopeptidase
HWQ50_14335	COG3177	Filamentation induced by cAMP protein fic
HWQ50_14340	COG0514	ATP-dependent DNA helicase (RecQ)
HWQ50_14345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWQ50_14345	COG1754	DNA topoisomerase type I activity
HWQ50_14365	COG2801	Transposase and inactivated derivatives
HWQ50_14370	COG2963	transposase activity
HWQ50_14395	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HWQ50_14395	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HWQ50_14405	COG0542	response to heat
HWQ50_14440	COG0789	Transcriptional regulator
HWQ50_14450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ50_14450	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_14455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWQ50_14460	COG0243	molybdopterin cofactor binding
HWQ50_14480	COG1280	lysine exporter protein (LysE YggA)
HWQ50_14495	COG0542	response to heat
HWQ50_14565	COG1607	acyl-coa hydrolase
HWQ50_14570	COG1959	2 iron, 2 sulfur cluster binding
HWQ50_14580	COG2819	hydrolase of the alpha beta superfamily
HWQ50_14625	COG0583	DNA-binding transcription factor activity
HWQ50_14635	COG4106	trans-aconitate 2-methyltransferase activity
HWQ50_14645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWQ50_14650	COG1459	type II secretion system
HWQ50_14660	COG2165	general secretion pathway protein
HWQ50_14700	COG0720	synthase
HWQ50_14705	COG3604	Transcriptional regulator
HWQ50_14765	COG0840	transmembrane signaling receptor activity
HWQ50_14770	COG2056	Na+-H+ antiporter family
HWQ50_14790	COG2226	methyltransferase
HWQ50_14885	COG2153	protein acetylation
HWQ50_14890	COG2850	peptidyl-arginine hydroxylation
HWQ50_14930	COG1278	Cold shock
HWQ50_14940	COG0542	response to heat
HWQ50_14945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HWQ50_14960	COG0492	ferredoxin-NADP+ reductase activity
HWQ50_14975	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWQ50_14990	COG0435	Glutathione S-transferase
HWQ50_14995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWQ50_15000	COG2920	part of a sulfur-relay system
HWQ50_15040	COG0583	DNA-binding transcription factor activity
HWQ50_15045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ50_15050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_15060	COG1960	acyl-CoA dehydrogenase activity
HWQ50_15065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_15075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_15090	COG2197	response regulator
HWQ50_15095	COG4771	TonB-dependent receptor
HWQ50_15140	COG2205	protein histidine kinase activity
HWQ50_15140	COG0784	Response regulator, receiver
HWQ50_15140	COG2198	Histidine kinase
HWQ50_15140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ50_15205	COG0419	ATPase involved in DNA repair
HWQ50_15220	COG3723	Recombinational DNA repair protein, rece pathway
HWQ50_15250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HWQ50_15345	COG5484	DNA packaging
HWQ50_15345	COG3728	DNA packaging
HWQ50_15455	COG3179	chitinase
HWQ50_15490	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ50_15505	COG1522	sequence-specific DNA binding
HWQ50_15535	COG4191	Histidine kinase
HWQ50_15560	COG5001	Diguanylate cyclase
HWQ50_15560	COG2203	Gaf domain
HWQ50_15560	COG4251	negative regulation of phosphorylation
HWQ50_15560	COG3706	GGDEF domain
HWQ50_15570	COG0659	secondary active sulfate transmembrane transporter activity
HWQ50_15610	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_15620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ50_15630	COG0183	Belongs to the thiolase family
HWQ50_15635	COG1960	acyl-CoA dehydrogenase activity
HWQ50_15685	COG0729	surface antigen
HWQ50_15695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWQ50_15700	COG2267	carboxylic ester hydrolase activity
HWQ50_15705	COG0671	phosphoesterase, PA-phosphatase related
HWQ50_15705	COG2453	phosphatase
HWQ50_15720	COG4589	Belongs to the CDS family
HWQ50_15725	COG0667	Aldo Keto reductase
HWQ50_15735	COG1115	amino acid carrier protein
HWQ50_15745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWQ50_15765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_15770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_15775	COG1538	Outer membrane efflux protein
HWQ50_15835	COG0543	2 iron, 2 sulfur cluster binding
HWQ50_15835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ50_15840	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWQ50_15845	COG4638	Rieske (2fe-2S)
HWQ50_15860	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ50_15870	COG3485	protocatechuate 3,4-dioxygenase
HWQ50_15905	COG2807	transmembrane transport
HWQ50_15910	COG0590	tRNA wobble adenosine to inosine editing
HWQ50_15925	COG2318	DinB family
HWQ50_15990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ50_15995	COG2863	cytochrome
HWQ50_16000	COG3258	Cytochrome c
HWQ50_16005	COG0642	Histidine kinase
HWQ50_16040	COG0625	glutathione transferase activity
HWQ50_16060	COG0583	DNA-binding transcription factor activity
HWQ50_16065	COG1595	DNA-templated transcription, initiation
HWQ50_16070	COG3712	iron ion homeostasis
HWQ50_16095	COG3210	domain, Protein
HWQ50_16130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWQ50_16140	COG2382	esterase
HWQ50_16160	COG0583	DNA-binding transcription factor activity
HWQ50_16180	COG1760	l-serine dehydratase
HWQ50_16185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWQ50_16220	COG2217	Heavy metal translocating P-type atpase
HWQ50_16235	COG0583	DNA-binding transcription factor activity
HWQ50_16250	COG1566	PFAM secretion protein HlyD family protein
HWQ50_16305	COG1335	isochorismatase
HWQ50_16315	COG0583	DNA-binding transcription factor activity
HWQ50_16355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWQ50_16360	COG1121	(ABC) transporter
HWQ50_16455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_16480	COG0735	belongs to the Fur family
HWQ50_16490	COG1304	FMN binding
HWQ50_16520	COG4566	intracellular signal transduction
HWQ50_16610	COG3829	transcription factor binding
HWQ50_16635	COG3829	transcription factor binding
HWQ50_16640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWQ50_16645	COG0584	glycerophosphoryl diester phosphodiesterase
HWQ50_16650	COG2011	ABC-type metal ion transport system permease component
HWQ50_16660	COG1464	Belongs to the NlpA lipoprotein family
HWQ50_16685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWQ50_16690	COG1070	Carbohydrate kinase
HWQ50_16695	COG0246	Mannitol dehydrogenase
HWQ50_16710	COG1175	transmembrane transport
HWQ50_16730	COG4771	TonB-dependent receptor
HWQ50_16745	COG1917	Cupin 2, conserved barrel domain protein
HWQ50_16745	COG4977	sequence-specific DNA binding
HWQ50_16760	COG1116	anion transmembrane transporter activity
HWQ50_16765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ50_16770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ50_16790	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_16805	COG3265	gluconokinase activity
HWQ50_16810	COG1609	Transcriptional regulator
HWQ50_16820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_16825	COG0583	DNA-binding transcription factor activity
HWQ50_16845	COG1396	sequence-specific DNA binding
HWQ50_16855	COG2175	clavaminate synthase activity
HWQ50_16865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HWQ50_16895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ50_16895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ50_16905	COG3469	chitinase activity
HWQ50_16910	COG2188	Transcriptional regulator
HWQ50_16915	COG1053	succinate dehydrogenase
HWQ50_16930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ50_16960	COG4772	TonB-dependent receptor
HWQ50_17005	COG0431	NADPH-dependent FMN reductase
HWQ50_17010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWQ50_17020	COG0640	Transcriptional regulator
HWQ50_17025	COG2207	Transcriptional regulator
HWQ50_17030	COG1064	alcohol dehydrogenase
HWQ50_17055	COG1309	transcriptional regulator
HWQ50_17065	COG2329	Antibiotic biosynthesis monooxygenase
HWQ50_17100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWQ50_17110	COG1609	Transcriptional regulator
HWQ50_17140	COG0252	asparaginase activity
HWQ50_17145	COG1115	amino acid carrier protein
HWQ50_17195	COG1053	succinate dehydrogenase
HWQ50_17205	COG0728	peptidoglycan biosynthetic process
HWQ50_17265	COG2258	MOSC domain
HWQ50_17300	COG2801	Transposase and inactivated derivatives
HWQ50_17320	COG2963	transposase activity
HWQ50_17330	COG2508	Transcriptional regulator
HWQ50_17340	COG4447	cellulose binding
HWQ50_17345	COG2409	Drug exporters of the RND superfamily
HWQ50_17380	COG2072	flavoprotein involved in K transport
HWQ50_17395	COG0531	amino acid
HWQ50_17400	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_17405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWQ50_17420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ50_17425	COG3162	membrane
HWQ50_17430	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_17435	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_17465	COG3008	intermembrane lipid transfer
HWQ50_17470	COG2995	paraquat-inducible protein a
HWQ50_17475	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_17485	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ50_17490	COG2271	Major facilitator Superfamily
HWQ50_17505	COG3618	amidohydrolase
HWQ50_17510	COG2271	Major facilitator Superfamily
HWQ50_17545	COG0765	amino acid transport
HWQ50_17550	COG0765	amino acid transport
HWQ50_17565	COG2084	Dehydrogenase
HWQ50_17575	COG2130	NADP-dependent
HWQ50_17580	COG1309	transcriptional regulator
HWQ50_17600	COG0366	Alpha amylase catalytic
HWQ50_17605	COG0517	IMP dehydrogenase activity
HWQ50_17640	COG2890	protein-(glutamine-N5) methyltransferase activity
HWQ50_17655	COG0784	Response regulator, receiver
HWQ50_17655	COG4191	Histidine kinase
HWQ50_17685	COG1363	Peptidase, m42
HWQ50_17725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWQ50_17765	COG3568	Endonuclease Exonuclease Phosphatase
HWQ50_17770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ50_17775	COG0392	lysyltransferase activity
HWQ50_17785	COG0366	Alpha amylase catalytic
HWQ50_17805	COG1285	pathogenesis
HWQ50_17835	COG0058	SHG alpha-glucan phosphorylase activity
HWQ50_17850	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_17855	COG1546	Belongs to the CinA family
HWQ50_17885	COG2323	membrane
HWQ50_17905	COG3121	Chaperone
HWQ50_17920	COG3121	Chaperone
HWQ50_17930	COG3969	phosphoadenosine phosphosulfate
HWQ50_17935	COG1475	DNA binding
HWQ50_17940	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_17945	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HWQ50_17950	COG0583	DNA-binding transcription factor activity
HWQ50_17980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ50_17980	COG2169	Transcriptional regulator
HWQ50_17995	COG0583	DNA-binding transcription factor activity
HWQ50_18000	COG2814	Major facilitator Superfamily
HWQ50_18020	COG1984	allophanate hydrolase subunit 2
HWQ50_18030	COG0028	Belongs to the TPP enzyme family
HWQ50_18040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWQ50_18045	COG1045	serine acetyltransferase
HWQ50_18050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWQ50_18070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ50_18075	COG0300	oxidoreductase activity
HWQ50_18115	COG2814	Major facilitator Superfamily
HWQ50_18125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ50_18145	COG0596	Alpha beta hydrolase
HWQ50_18150	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWQ50_18155	COG0367	asparagine synthase
HWQ50_18165	COG1522	sequence-specific DNA binding
HWQ50_18180	COG1113	amino acid transport
HWQ50_18185	COG2010	Cytochrome c
HWQ50_18190	COG2010	Cytochrome c
HWQ50_18210	COG5001	Diguanylate cyclase
HWQ50_18225	COG2192	nodulation
HWQ50_18230	COG2814	Major facilitator Superfamily
HWQ50_18260	COG1104	cysteine desulfurase activity
HWQ50_18265	COG4172	Belongs to the ABC transporter superfamily
HWQ50_18270	COG4239	(ABC) transporter, permease
HWQ50_18275	COG4174	ABC transporter (Permease)
HWQ50_18285	COG4771	TonB-dependent receptor
HWQ50_18300	COG0583	DNA-binding transcription factor activity
HWQ50_18320	COG1595	DNA-templated transcription, initiation
HWQ50_18340	COG2207	Transcriptional regulator
HWQ50_18360	COG0564	pseudouridine synthase activity
HWQ50_18370	COG0531	amino acid
HWQ50_18375	COG0174	glutamine synthetase
HWQ50_18395	COG0028	Belongs to the TPP enzyme family
HWQ50_18410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ50_18430	COG1522	sequence-specific DNA binding
HWQ50_18470	COG1309	transcriptional regulator
HWQ50_18475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_18480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_18490	COG3204	pilus organization
HWQ50_18495	COG0789	Transcriptional regulator
HWQ50_18500	COG1960	acyl-CoA dehydrogenase activity
HWQ50_18505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWQ50_18535	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWQ50_18545	COG2271	Major facilitator Superfamily
HWQ50_18550	COG3290	protein histidine kinase activity
HWQ50_18550	COG3829	transcription factor binding
HWQ50_18555	COG2610	gluconate transmembrane transporter activity
HWQ50_18560	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_18565	COG2031	fatty acid transporter
HWQ50_18580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ50_18585	COG0583	DNA-binding transcription factor activity
HWQ50_18590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ50_18595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ50_18615	COG2205	protein histidine kinase activity
HWQ50_18680	COG3851	Histidine kinase
HWQ50_18700	COG0784	Response regulator, receiver
HWQ50_18700	COG2205	protein histidine kinase activity
HWQ50_18720	COG2194	sulfuric ester hydrolase activity
HWQ50_18760	COG0488	(ABC) transporter
HWQ50_18775	COG0583	DNA-binding transcription factor activity
HWQ50_18780	COG1278	Cold shock
HWQ50_18830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWQ50_18835	COG1609	Transcriptional regulator
HWQ50_18840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWQ50_18845	COG1129	ABC transporter
HWQ50_18855	COG2204	response regulator
HWQ50_18875	COG2010	Cytochrome c
HWQ50_18880	COG0753	catalase activity
HWQ50_18905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWQ50_18910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HWQ50_18915	COG2080	2 iron, 2 sulfur cluster binding
HWQ50_18940	COG1944	ATP diphosphatase activity
HWQ50_18960	COG4771	TonB-dependent receptor
HWQ50_18965	COG0275	rRNA processing
HWQ50_18970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWQ50_18970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWQ50_18985	COG0579	oxidoreductase
HWQ50_19015	COG1595	DNA-templated transcription, initiation
HWQ50_19020	COG3712	iron ion homeostasis
HWQ50_19040	COG2814	Major facilitator Superfamily
HWQ50_19090	COG2197	response regulator
HWQ50_19115	COG2366	antibiotic biosynthetic process
HWQ50_19130	COG0625	glutathione transferase activity
HWQ50_19145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ50_19150	COG0417	DNA replication proofreading
HWQ50_19195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_19265	COG1309	transcriptional regulator
HWQ50_19285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HWQ50_19290	COG0583	DNA-binding transcription factor activity
HWQ50_19305	COG2354	Protein conserved in bacteria
HWQ50_19310	COG3278	Belongs to the heme-copper respiratory oxidase family
HWQ50_19320	COG2239	Acts as a magnesium transporter
HWQ50_19335	COG2203	Gaf domain
HWQ50_19335	COG4251	negative regulation of phosphorylation
HWQ50_19335	COG5001	Diguanylate cyclase
HWQ50_19335	COG3706	GGDEF domain
HWQ50_19340	COG4977	sequence-specific DNA binding
HWQ50_19345	COG3813	Protein conserved in bacteria
HWQ50_19410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ50_19435	COG0604	alcohol dehydrogenase
HWQ50_19440	COG0616	signal peptide processing
HWQ50_19460	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_19465	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_19470	COG0583	DNA-binding transcription factor activity
HWQ50_19495	COG1024	Enoyl-CoA hydratase
HWQ50_19505	COG0531	amino acid
HWQ50_19520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWQ50_19540	COG0741	lytic transglycosylase activity
HWQ50_19540	COG1388	LysM domain
HWQ50_19545	COG4166	transmembrane transport
HWQ50_19550	COG4166	transmembrane transport
HWQ50_19555	COG4174	ABC transporter (Permease)
HWQ50_19560	COG4239	(ABC) transporter, permease
HWQ50_19565	COG4172	Belongs to the ABC transporter superfamily
HWQ50_19575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ50_19590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWQ50_19610	COG0745	RESPONSE REGULATOR receiver
HWQ50_19615	COG2205	protein histidine kinase activity
HWQ50_19620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWQ50_19675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWQ50_19695	COG0589	response to stress
HWQ50_19715	COG2201	protein-glutamate methylesterase activity
HWQ50_19725	COG2223	nitrite transmembrane transporter activity
HWQ50_19730	COG0515	serine threonine protein kinase
HWQ50_19735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ50_19740	COG2146	nitrite reductase [NAD(P)H] activity
HWQ50_19745	COG0243	molybdopterin cofactor binding
HWQ50_19765	COG0668	transmembrane transport
HWQ50_19800	COG0189	ligase activity
HWQ50_19800	COG4067	protein conserved in archaea
HWQ50_19840	COG2909	trisaccharide binding
HWQ50_19845	COG2909	trisaccharide binding
HWQ50_19880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWQ50_19930	COG0519	Catalyzes the synthesis of GMP from XMP
HWQ50_19945	COG0667	Aldo Keto reductase
HWQ50_19955	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ50_19955	COG1024	Enoyl-CoA hydratase
HWQ50_19960	COG0183	Belongs to the thiolase family
HWQ50_19985	COG1305	Transglutaminase-like
HWQ50_19995	COG2308	Evidence 4 Homologs of previously reported genes of
HWQ50_20020	COG1317	bacterial-type flagellum organization
HWQ50_20130	COG4789	Type iii secretion
HWQ50_20180	COG4790	Type iii secretion
HWQ50_20185	COG4794	Type iii secretion
HWQ50_20190	COG4791	protein targeting
HWQ50_20195	COG4792	protein secretion
HWQ50_20275	COG2840	Smr protein MutS2
HWQ50_20295	COG0515	serine threonine protein kinase
HWQ50_20295	COG2815	serine threonine protein kinase
HWQ50_20335	COG2204	response regulator
HWQ50_20390	COG3209	COG3209 Rhs family protein
HWQ50_20400	COG0625	glutathione transferase activity
HWQ50_20405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ50_20420	COG3135	benzoate transporter
HWQ50_20435	COG2130	NADP-dependent
HWQ50_20445	COG0840	transmembrane signaling receptor activity
HWQ50_20455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ50_20495	COG0745	RESPONSE REGULATOR receiver
HWQ50_20500	COG2205	protein histidine kinase activity
HWQ50_20525	COG1960	acyl-CoA dehydrogenase activity
HWQ50_20535	COG1024	Enoyl-CoA hydratase
HWQ50_20540	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ50_20545	COG2186	Transcriptional regulator
HWQ50_20550	COG2807	transmembrane transport
HWQ50_20555	COG0628	permease
HWQ50_20565	COG0625	glutathione transferase activity
HWQ50_20595	COG1022	Amp-dependent synthetase and ligase
HWQ50_20625	COG0784	Response regulator, receiver
HWQ50_20625	COG2205	protein histidine kinase activity
HWQ50_20625	COG5002	protein histidine kinase activity
HWQ50_20665	COG1846	Transcriptional regulator
HWQ50_20670	COG2080	2 iron, 2 sulfur cluster binding
HWQ50_20675	COG2010	Cytochrome c
HWQ50_20675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWQ50_20680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWQ50_20680	COG2010	Cytochrome c
HWQ50_20685	COG2207	Transcriptional regulator
HWQ50_20760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWQ50_20765	COG1053	succinate dehydrogenase
HWQ50_20770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HWQ50_20775	COG2009	succinate dehydrogenase
HWQ50_20805	COG2084	Dehydrogenase
HWQ50_20820	COG3738	Protein conserved in bacteria
HWQ50_20845	COG0251	oxidation-reduction process
HWQ50_20850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_20855	COG0174	glutamine synthetase
HWQ50_20860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_20885	COG0840	transmembrane signaling receptor activity
HWQ50_20900	COG3278	Belongs to the heme-copper respiratory oxidase family
HWQ50_20915	COG2010	Cytochrome c
HWQ50_20920	COG3278	Belongs to the heme-copper respiratory oxidase family
HWQ50_20935	COG2010	Cytochrome c
HWQ50_20940	COG0348	domain, Protein
HWQ50_20950	COG2217	Heavy metal translocating P-type atpase
HWQ50_20990	COG2076	Multidrug Resistance protein
HWQ50_21020	COG1960	acyl-CoA dehydrogenase activity
HWQ50_21035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWQ50_21060	COG1196	nuclear chromosome segregation
HWQ50_21090	COG0402	S-adenosylhomocysteine deaminase activity
HWQ50_21100	COG2252	PERMEase
HWQ50_21160	COG2233	PERMEase
HWQ50_21175	COG1309	transcriptional regulator
HWQ50_21185	COG3960	tartronate-semialdehyde synthase activity
HWQ50_21190	COG3622	Belongs to the hyi family
HWQ50_21195	COG2084	Dehydrogenase
HWQ50_21205	COG0469	pyruvate kinase activity
HWQ50_21210	COG4413	Urea transporter
HWQ50_21215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWQ50_21230	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWQ50_21240	COG3192	ethanolamine utilization protein
HWQ50_21255	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ50_21260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWQ50_21335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWQ50_21350	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_21355	COG1496	oxidoreductase activity
HWQ50_21380	COG0835	chemotaxis
HWQ50_21390	COG1192	Involved in chromosome partitioning
HWQ50_21395	COG1360	Flagellar Motor Protein
HWQ50_21400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWQ50_21410	COG0643	Histidine kinase
HWQ50_21410	COG0784	Response regulator, receiver
HWQ50_21410	COG2198	Histidine kinase
HWQ50_21440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWQ50_21445	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWQ50_21465	COG1987	bacterial-type flagellum assembly
HWQ50_21505	COG2832	Protein of unknown function (DUF454)
HWQ50_21520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_21525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_21535	COG3300	MHYT domain
HWQ50_21535	COG5001	Diguanylate cyclase
HWQ50_21570	COG0488	(ABC) transporter
HWQ50_21625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ50_21635	COG0583	DNA-binding transcription factor activity
HWQ50_21650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HWQ50_21660	COG1196	nuclear chromosome segregation
HWQ50_21660	COG3264	Mechanosensitive ion channel
HWQ50_21665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HWQ50_21665	COG0116	Belongs to the methyltransferase superfamily
HWQ50_21675	COG0210	DNA helicase
HWQ50_21700	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HWQ50_21740	COG0438	transferase activity, transferring glycosyl groups
HWQ50_21750	COG0438	transferase activity, transferring glycosyl groups
HWQ50_21775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWQ50_21785	COG1450	Type ii and iii secretion system protein
HWQ50_21795	COG2207	Transcriptional regulator
HWQ50_21800	COG4221	oxidoreductase activity
HWQ50_21820	COG1247	-acetyltransferase
HWQ50_21840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWQ50_21865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_21870	COG4221	oxidoreductase activity
HWQ50_21875	COG2020	methyltransferase activity
HWQ50_21880	COG3634	alkyl hydroperoxide reductase activity
HWQ50_21885	COG1309	transcriptional regulator
HWQ50_21890	COG0384	phenazine biosynthesis protein PhzF
HWQ50_21930	COG5006	permease, DMT superfamily
HWQ50_21945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWQ50_21960	COG3795	YCII-related domain
HWQ50_21970	COG2814	Major facilitator Superfamily
HWQ50_21975	COG4941	Belongs to the sigma-70 factor family
HWQ50_21985	COG3795	YCII-related domain
HWQ50_21995	COG2197	response regulator
HWQ50_22000	COG1982	Orn Lys Arg decarboxylase major
HWQ50_22005	COG0189	ligase activity
HWQ50_22010	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_22025	COG0765	amino acid transport
HWQ50_22030	COG0765	amino acid transport
HWQ50_22035	COG1126	abc transporter atp-binding protein
HWQ50_22060	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_22075	COG1253	flavin adenine dinucleotide binding
HWQ50_22080	COG0300	oxidoreductase activity
HWQ50_22090	COG0583	DNA-binding transcription factor activity
HWQ50_22095	COG3591	Belongs to the peptidase S1B family
HWQ50_22095	COG1864	DNA RNA non-specific endonuclease
HWQ50_22100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWQ50_22105	COG4319	ketosteroid isomerase
HWQ50_22120	COG4774	siderophore transport
HWQ50_22165	COG2814	Major facilitator Superfamily
HWQ50_22185	COG0583	DNA-binding transcription factor activity
HWQ50_22195	COG0121	glutamine amidotransferase
HWQ50_22225	COG3712	iron ion homeostasis
HWQ50_22230	COG1595	DNA-templated transcription, initiation
HWQ50_22245	COG1230	cation diffusion facilitator family transporter
HWQ50_22250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWQ50_22310	COG1960	acyl-CoA dehydrogenase activity
HWQ50_22330	COG0406	alpha-ribazole phosphatase activity
HWQ50_22360	COG0778	Nitroreductase
HWQ50_22375	COG4206	TonB-dependent receptor
HWQ50_22385	COG1802	Transcriptional regulator
HWQ50_22395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_22425	COG0477	Major facilitator Superfamily
HWQ50_22445	COG0765	amino acid transport
HWQ50_22455	COG1126	abc transporter atp-binding protein
HWQ50_22465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ50_22470	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_22525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWQ50_22530	COG1518	maintenance of DNA repeat elements
HWQ50_22545	COG1857	crispr-associated protein
HWQ50_22570	COG0784	Response regulator, receiver
HWQ50_22570	COG4191	Histidine kinase
HWQ50_22630	COG1289	transmembrane transporter activity
HWQ50_22645	COG2207	Transcriptional regulator
HWQ50_22670	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ50_22680	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HWQ50_22705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWQ50_22715	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ50_22720	COG0367	asparagine synthase
HWQ50_22730	COG2211	Major facilitator Superfamily
HWQ50_22780	COG1335	isochorismatase
HWQ50_22785	COG0583	DNA-binding transcription factor activity
HWQ50_22795	COG0791	NLP P60 protein
HWQ50_22800	COG0791	NLP P60 protein
HWQ50_22810	COG3829	transcription factor binding
HWQ50_22825	COG2818	Glycosylase
HWQ50_22850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWQ50_22855	COG1960	acyl-CoA dehydrogenase activity
HWQ50_22865	COG0625	glutathione transferase activity
HWQ50_22885	COG5002	protein histidine kinase activity
HWQ50_22885	COG3447	MASE1 domain protein
HWQ50_22885	COG5001	Diguanylate cyclase
HWQ50_22905	COG4459	periplasmic nitrate reductase
HWQ50_22910	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ50_22910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ50_22925	COG3043	anaerobic respiration
HWQ50_22930	COG3005	denitrification pathway
HWQ50_22935	COG2951	lytic endotransglycosylase activity
HWQ50_22940	COG0861	Integral membrane protein TerC family
HWQ50_22945	COG0753	catalase activity
HWQ50_22965	COG2977	Belongs to the P-Pant transferase superfamily
HWQ50_22970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWQ50_22985	COG2226	methyltransferase
HWQ50_23000	COG2205	protein histidine kinase activity
HWQ50_23005	COG0745	RESPONSE REGULATOR receiver
HWQ50_23010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWQ50_23010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWQ50_23015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWQ50_23020	COG1943	Transposase
HWQ50_23045	COG0531	amino acid
HWQ50_23075	COG0583	DNA-binding transcription factor activity
HWQ50_23080	COG3257	ureidoglycine aminohydrolase activity
HWQ50_23095	COG3321	synthase
HWQ50_23095	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_23095	COG0604	alcohol dehydrogenase
HWQ50_23100	COG2197	response regulator
HWQ50_23140	COG0583	DNA-binding transcription factor activity
HWQ50_23145	COG0667	Aldo Keto reductase
HWQ50_23170	COG0242	peptide deformylase activity
HWQ50_23180	COG2199	diguanylate cyclase activity
HWQ50_23185	COG2885	chlorophyll binding
HWQ50_23215	COG1132	(ABC) transporter
HWQ50_23225	COG4628	conserved protein (DUF2132)
HWQ50_23230	COG2133	pyrroloquinoline quinone binding
HWQ50_23245	COG2207	Transcriptional regulator
HWQ50_23250	COG0477	Major facilitator Superfamily
HWQ50_23265	COG2882	bacterial-type flagellum organization
HWQ50_23320	COG1516	flagellar protein fliS
HWQ50_23325	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HWQ50_23335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWQ50_23340	COG0438	transferase activity, transferring glycosyl groups
HWQ50_23340	COG1216	Glycosyl transferase, family 2
HWQ50_23365	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_23370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWQ50_23390	COG1256	bacterial-type flagellum assembly
HWQ50_23415	COG4787	bacterial-type flagellum-dependent cell motility
HWQ50_23425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HWQ50_23435	COG1815	bacterial-type flagellum-dependent cell motility
HWQ50_23480	COG0326	Molecular chaperone. Has ATPase activity
HWQ50_23495	COG3189	MarR family transcriptional regulator
HWQ50_23515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWQ50_23530	COG2212	antiporter activity
HWQ50_23535	COG1863	multisubunit Na H antiporter MnhE subunit
HWQ50_23540	COG0651	ATP synthesis coupled electron transport
HWQ50_23545	COG1006	Multisubunit Na H antiporter MnhC subunit
HWQ50_23550	COG2111	Na H antiporter
HWQ50_23550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWQ50_23555	COG3133	Outer membrane lipoprotein
HWQ50_23565	COG1929	Belongs to the glycerate kinase type-1 family
HWQ50_23570	COG2610	gluconate transmembrane transporter activity
HWQ50_23575	COG3835	regulator
HWQ50_23585	COG2885	chlorophyll binding
HWQ50_23600	COG1199	ATP-dependent helicase activity
HWQ50_23640	COG2860	membrane
HWQ50_23655	COG0653	protein targeting
HWQ50_23660	COG0625	glutathione transferase activity
HWQ50_23685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ50_23690	COG1012	belongs to the aldehyde dehydrogenase family
HWQ50_23710	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_23715	COG1960	acyl-CoA dehydrogenase activity
HWQ50_23720	COG1024	Enoyl-CoA hydratase
HWQ50_23725	COG1960	acyl-CoA dehydrogenase activity
HWQ50_23735	COG2814	Major facilitator Superfamily
HWQ50_23740	COG2030	dehydratase
HWQ50_23780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HWQ50_23785	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HWQ50_23800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWQ50_23810	COG0425	Belongs to the sulfur carrier protein TusA family
HWQ50_23865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ50_23870	COG3188	usher protein
HWQ50_23890	COG1051	belongs to the nudix hydrolase family
HWQ50_23915	COG0602	queuosine metabolic process
HWQ50_23920	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HWQ50_23950	COG0824	Thioesterase
HWQ50_23980	COG0783	Belongs to the Dps family
HWQ50_24025	COG3118	belongs to the thioredoxin family
HWQ50_24060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWQ50_24075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWQ50_24115	COG3122	Protein conserved in bacteria
HWQ50_24125	COG3956	TIGRFAM MazG family protein
HWQ50_24130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ50_24160	COG2205	protein histidine kinase activity
HWQ50_24160	COG5002	protein histidine kinase activity
HWQ50_24160	COG0784	Response regulator, receiver
HWQ50_24165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWQ50_24215	COG3038	cytochrome b561
HWQ50_24230	COG4807	Protein conserved in bacteria
HWQ50_24240	COG2239	Acts as a magnesium transporter
HWQ50_24310	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HWQ50_24405	COG2301	Belongs to the HpcH HpaI aldolase family
HWQ50_24415	COG2079	MmgE PrpD family protein
HWQ50_24425	COG1960	acyl-CoA dehydrogenase activity
HWQ50_24430	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HWQ50_24435	COG0583	DNA-binding transcription factor activity
HWQ50_24440	COG0583	DNA-binding transcription factor activity
HWQ50_24490	COG1113	amino acid transport
HWQ50_24510	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_24510	COG3321	synthase
HWQ50_24510	COG0604	alcohol dehydrogenase
HWQ50_24520	COG5002	protein histidine kinase activity
HWQ50_24520	COG5001	Diguanylate cyclase
HWQ50_24540	COG0271	Belongs to the BolA IbaG family
HWQ50_24580	COG0492	ferredoxin-NADP+ reductase activity
HWQ50_24585	COG0450	alkyl hydroperoxide reductase
HWQ50_24620	COG1307	EDD domain protein, DegV family
HWQ50_24630	COG1309	transcriptional regulator
HWQ50_24635	COG0386	Belongs to the glutathione peroxidase family
HWQ50_24655	COG0204	Acyl-transferase
HWQ50_24660	COG2885	chlorophyll binding
HWQ50_24665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ50_24680	COG2267	carboxylic ester hydrolase activity
HWQ50_24695	COG1432	Conserved Protein
HWQ50_24700	COG4974	Belongs to the 'phage' integrase family
HWQ50_24800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWQ50_24815	COG0546	phosphoglycolate phosphatase activity
HWQ50_24830	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWQ50_24845	COG0656	L-ascorbic acid biosynthetic process
HWQ50_24870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWQ50_24880	COG1802	Transcriptional regulator
HWQ50_24890	COG0372	Belongs to the citrate synthase family
HWQ50_24905	COG2079	MmgE PrpD family protein
HWQ50_24920	COG1113	amino acid transport
HWQ50_24950	COG0583	DNA-binding transcription factor activity
HWQ50_24955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ50_24965	COG4206	TonB-dependent receptor
HWQ50_24975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWQ50_25040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWQ50_25120	COG3180	Ammonia monooxygenase
HWQ50_25130	COG2720	vancomycin resistance protein
HWQ50_25145	COG1960	acyl-CoA dehydrogenase activity
HWQ50_25150	COG1024	Enoyl-CoA hydratase
HWQ50_25170	COG2910	NAD(P)H-binding
HWQ50_25175	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HWQ50_25275	COG0583	DNA-binding transcription factor activity
HWQ50_25290	COG0463	Glycosyl transferase, family 2
HWQ50_25300	COG0154	amidase activity
HWQ50_25320	COG0583	DNA-binding transcription factor activity
HWQ50_25330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ50_25365	COG2831	hemolysin activation secretion protein
HWQ50_25505	COG0420	3'-5' exonuclease activity
HWQ50_25515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWQ50_25520	COG1074	ATP-dependent DNA helicase activity
HWQ50_25525	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HWQ50_25530	COG0095	Lipoate-protein ligase
HWQ50_25535	COG0697	spore germination
HWQ50_25550	COG0840	transmembrane signaling receptor activity
HWQ50_25560	COG0306	phosphate transporter
HWQ50_25620	COG4964	Belongs to the GSP D family
HWQ50_25640	COG0433	COG0433 Predicted ATPase
HWQ50_25675	COG0788	formyltetrahydrofolate deformylase activity
HWQ50_25685	COG2925	Exonuclease
HWQ50_25715	COG0714	Associated with various cellular activities
HWQ50_25745	COG0589	response to stress
HWQ50_25755	COG1024	Enoyl-CoA hydratase
HWQ50_25765	COG3706	GGDEF domain
HWQ50_25785	COG0693	protein deglycase activity
HWQ50_25800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ50_25815	COG0154	amidase activity
HWQ50_25825	COG1473	amidohydrolase
HWQ50_25840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWQ50_25845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ50_25845	COG0426	domain, Protein
HWQ50_25865	COG0589	response to stress
HWQ50_25880	COG2814	Major facilitator Superfamily
HWQ50_25885	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_25900	COG1918	ferrous iron import across plasma membrane
HWQ50_25915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWQ50_25955	COG1704	LemA family
HWQ50_25980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_25985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_26000	COG3642	lipopolysaccharide core region biosynthetic process
HWQ50_26010	COG2205	protein histidine kinase activity
HWQ50_26015	COG0745	RESPONSE REGULATOR receiver
HWQ50_26050	COG3030	protein affecting phage T7 exclusion by the F plasmid
HWQ50_26060	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_26085	COG0668	transmembrane transport
HWQ50_26095	COG0745	RESPONSE REGULATOR receiver
HWQ50_26110	COG2096	Adenosyltransferase
HWQ50_26115	COG0494	nUDIX hydrolase
HWQ50_26135	COG1196	nuclear chromosome segregation
HWQ50_26135	COG0741	lytic transglycosylase activity
HWQ50_26135	COG0739	heme binding
HWQ50_26180	COG0772	Belongs to the SEDS family
HWQ50_26195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWQ50_26230	COG3107	peptidoglycan biosynthetic process
HWQ50_26245	COG2823	Periplasmic or secreted lipoprotein
HWQ50_26250	COG2969	positive regulation of protein catabolic process
HWQ50_26255	COG0625	glutathione transferase activity
HWQ50_26260	COG2857	Cytochrome c1
HWQ50_26265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWQ50_26270	COG0723	plastoquinol--plastocyanin reductase activity
HWQ50_26285	COG0667	Aldo Keto reductase
HWQ50_26290	COG1960	acyl-CoA dehydrogenase activity
HWQ50_26305	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWQ50_26315	COG2945	thiolester hydrolase activity
HWQ50_26335	COG2951	lytic endotransglycosylase activity
HWQ50_26345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWQ50_26385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWQ50_26390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWQ50_26395	COG1127	ABC transporter
HWQ50_26410	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HWQ50_26425	COG1137	ATPase activity
HWQ50_26455	COG4974	Belongs to the 'phage' integrase family
HWQ50_26520	COG4695	Portal protein
HWQ50_26580	COG3772	lysozyme
HWQ50_26680	COG0312	modulator of DNA gyrase
HWQ50_26690	COG0312	modulator of DNA gyrase
HWQ50_26695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWQ50_26705	COG1530	ribonuclease E activity
HWQ50_26720	COG1792	Involved in formation and maintenance of cell shape
HWQ50_26725	COG1077	Cell shape determining protein MreB Mrl
HWQ50_26745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWQ50_26750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ50_26755	COG4676	Protein conserved in bacteria
HWQ50_26760	COG5445	Predicted secreted protein (DUF2300)
HWQ50_26775	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HWQ50_26780	COG4676	Protein conserved in bacteria
HWQ50_26785	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HWQ50_26800	COG0747	negative chemotaxis
HWQ50_26805	COG0747	negative chemotaxis
HWQ50_26820	COG0747	negative chemotaxis
HWQ50_26830	COG0747	negative chemotaxis
HWQ50_26835	COG0601	transmembrane transport
HWQ50_26840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWQ50_26845	COG0444	Belongs to the ABC transporter superfamily
HWQ50_26850	COG4608	Belongs to the ABC transporter superfamily
HWQ50_26865	COG1984	allophanate hydrolase subunit 2
HWQ50_26885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWQ50_26890	COG4774	siderophore transport
HWQ50_26905	COG2194	sulfuric ester hydrolase activity
HWQ50_26915	COG0019	diaminopimelate decarboxylase activity
HWQ50_26950	COG0582	viral genome integration into host DNA
HWQ50_27110	COG1252	NADH dehydrogenase
HWQ50_27115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWQ50_27230	COG1047	Peptidyl-prolyl cis-trans
HWQ50_27245	COG0196	riboflavin kinase activity
HWQ50_27260	COG3045	CreA protein
HWQ50_27285	COG0142	geranyltranstransferase activity
HWQ50_27300	COG0545	Peptidyl-prolyl cis-trans isomerase
HWQ50_27320	COG1067	ATP-dependent peptidase activity
HWQ50_27345	COG4650	regulator
HWQ50_27360	COG1690	Belongs to the RtcB family
HWQ50_27365	COG3541	Predicted nucleotidyltransferase
HWQ50_27385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWQ50_27410	COG0577	efflux transmembrane transporter activity
HWQ50_27410	COG1136	(ABC) transporter
HWQ50_27415	COG1136	(ABC) transporter
HWQ50_27415	COG0577	efflux transmembrane transporter activity
HWQ50_27420	COG0488	(ABC) transporter
HWQ50_27440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ50_27445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ50_27470	COG0523	cobalamin synthesis protein
HWQ50_27475	COG2879	small protein
HWQ50_27480	COG1966	Carbon starvation protein
HWQ50_27545	COG3608	succinylglutamate desuccinylase aspartoacylase
HWQ50_27545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HWQ50_27550	COG2010	Cytochrome c
HWQ50_27585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWQ50_27595	COG0833	amino acid
HWQ50_27600	COG2119	membrane
HWQ50_27615	COG0501	Belongs to the peptidase M48B family
HWQ50_27620	COG0840	transmembrane signaling receptor activity
HWQ50_27625	COG2135	peptidase activity
HWQ50_27630	COG1285	pathogenesis
HWQ50_27690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HWQ50_27745	COG1090	epimerase
HWQ50_27750	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HWQ50_27760	COG0789	Transcriptional regulator
HWQ50_27780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWQ50_27835	COG0012	GTP binding
HWQ50_27855	COG0288	reversible hydration of carbon dioxide
HWQ50_27865	COG0456	acetyltransferase
HWQ50_27910	COG1840	ABC-type Fe3 transport system, periplasmic component
HWQ50_27915	COG1178	ABC-type Fe3 transport system permease component
HWQ50_27920	COG3008	intermembrane lipid transfer
HWQ50_27925	COG2995	paraquat-inducible protein a
HWQ50_27930	COG2995	paraquat-inducible protein a
HWQ50_27970	COG1183	phosphatidylcholine synthase activity
HWQ50_27985	COG0028	Belongs to the TPP enzyme family
HWQ50_27995	COG3098	single-species biofilm formation
HWQ50_28005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWQ50_28040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWQ50_28045	COG4558	Periplasmic binding protein
HWQ50_28050	COG3720	iron ion transport
HWQ50_28055	COG4771	TonB-dependent receptor
HWQ50_28080	COG0436	Aminotransferase
HWQ50_28090	COG2321	neutral zinc metallopeptidase
HWQ50_28100	COG2252	PERMEase
HWQ50_28115	COG0436	Aminotransferase
HWQ50_28120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWQ50_28135	COG4191	Histidine kinase
HWQ50_28235	COG0195	Participates in both transcription termination and antitermination
HWQ50_28265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWQ50_28330	COG0497	DNA recombination
HWQ50_28360	COG2186	Transcriptional regulator
HWQ50_28365	COG1620	l-lactate permease
HWQ50_28415	COG0697	spore germination
HWQ50_28435	COG0697	spore germination
HWQ50_28440	COG1522	sequence-specific DNA binding
HWQ50_28450	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ50_28470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWQ50_28500	COG0509	glycine decarboxylation via glycine cleavage system
HWQ50_28575	COG4128	Pfam Zonular occludens toxin
HWQ50_28590	COG4974	Belongs to the 'phage' integrase family
HWQ50_28605	COG0531	amino acid
HWQ50_28620	COG3276	selenocysteine insertion sequence binding
HWQ50_28635	COG2864	formate dehydrogenase
HWQ50_28640	COG0437	4 iron, 4 sulfur cluster binding
HWQ50_28645	COG3383	formate dehydrogenase (NAD+) activity
HWQ50_28645	COG0243	molybdopterin cofactor binding
HWQ50_28650	COG3383	formate dehydrogenase (NAD+) activity
HWQ50_28650	COG0243	molybdopterin cofactor binding
HWQ50_28655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWQ50_28660	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ50_28660	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_28685	COG0463	Glycosyl transferase, family 2
HWQ50_28695	COG0534	Mate efflux family protein
HWQ50_28705	COG1283	sodium-dependent phosphate transmembrane transporter activity
HWQ50_28735	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HWQ50_28760	COG4221	oxidoreductase activity
HWQ50_28765	COG1272	protein, Hemolysin III
HWQ50_28800	COG0023	Translation Initiation Factor
HWQ50_28890	COG2095	MarC family integral membrane protein
HWQ50_28895	COG0683	leucine binding
HWQ50_28910	COG0411	ABC transporter
HWQ50_28955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWQ50_28970	COG0443	Heat shock 70 kDa protein
HWQ50_28995	COG0789	Transcriptional regulator
HWQ50_29000	COG2982	Protein involved in outer membrane biogenesis
HWQ50_29005	COG2193	ferroxidase activity
HWQ50_29015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWQ50_29020	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HWQ50_29080	COG3712	iron ion homeostasis
HWQ50_29085	COG1595	DNA-templated transcription, initiation
HWQ50_29105	COG2814	Major facilitator Superfamily
HWQ50_29115	COG0583	DNA-binding transcription factor activity
HWQ50_29140	COG4221	oxidoreductase activity
HWQ50_29145	COG2423	ornithine cyclodeaminase activity
HWQ50_29175	COG0583	DNA-binding transcription factor activity
HWQ50_29190	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HWQ50_29230	COG0668	transmembrane transport
HWQ50_29250	COG5001	Diguanylate cyclase
HWQ50_29250	COG3300	MHYT domain
HWQ50_29265	COG0305	Participates in initiation and elongation during chromosome replication
HWQ50_29295	COG0557	exoribonuclease II activity
HWQ50_29325	COG0330	HflC and HflK could
HWQ50_29330	COG0330	HflC and HflK could
HWQ50_29335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWQ50_29355	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWQ50_29360	COG0802	atpase or kinase
HWQ50_29365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HWQ50_29365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWQ50_29415	COG3300	MHYT domain
HWQ50_29415	COG5001	Diguanylate cyclase
HWQ50_29420	COG0560	Phosphoserine phosphatase
HWQ50_29420	COG3830	Belongs to the UPF0237 family
HWQ50_29430	COG1988	membrane-bound metal-dependent
HWQ50_29445	COG3577	Aspartyl protease
HWQ50_29460	COG3150	esterase
HWQ50_29465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWQ50_29475	COG0494	nUDIX hydrolase
HWQ50_29490	COG1538	Outer membrane efflux protein
HWQ50_29495	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ50_29510	COG0045	succinate-CoA ligase (ADP-forming) activity
HWQ50_29515	COG1960	acyl-CoA dehydrogenase activity
HWQ50_29520	COG1024	Enoyl-CoA hydratase
HWQ50_29525	COG0833	amino acid
HWQ50_29555	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ50_29555	COG1902	pentaerythritol trinitrate reductase activity
HWQ50_29565	COG1519	Transferase
HWQ50_29570	COG0583	DNA-binding transcription factor activity
HWQ50_29585	COG0667	Aldo Keto reductase
HWQ50_29595	COG1960	acyl-CoA dehydrogenase activity
HWQ50_29600	COG1960	acyl-CoA dehydrogenase activity
HWQ50_29625	COG1215	transferase activity, transferring glycosyl groups
HWQ50_29645	COG0438	transferase activity, transferring glycosyl groups
HWQ50_29650	COG2192	nodulation
HWQ50_29675	COG0438	transferase activity, transferring glycosyl groups
HWQ50_29680	COG0859	PFAM glycosyl transferase family 9
HWQ50_29685	COG0859	PFAM glycosyl transferase family 9
HWQ50_29720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HWQ50_29725	COG1960	acyl-CoA dehydrogenase activity
HWQ50_29735	COG1196	nuclear chromosome segregation
HWQ50_29735	COG3264	Mechanosensitive ion channel
HWQ50_29745	COG0730	response to heat
HWQ50_29750	COG2873	o-acetylhomoserine
HWQ50_29765	COG1192	Involved in chromosome partitioning
HWQ50_29770	COG0583	DNA-binding transcription factor activity
HWQ50_29775	COG2814	Major facilitator Superfamily
HWQ50_29800	COG0493	'glutamate synthase
HWQ50_29805	COG0070	glutamate synthase
HWQ50_29805	COG0067	glutamate synthase
HWQ50_29805	COG0069	glutamate synthase activity
HWQ50_29855	COG0281	malic enzyme
HWQ50_29875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA