locus-tag class description Y89_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Y89_0004 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y89_0009 ENOG4105C0D helicase Y89_0012 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Y89_0014 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Y89_0016 ENOG4108R3E Dna-3-methyladenine glycosylase i Y89_0019 ENOG4105EX9 Membrane Y89_0021 ENOG4105WAP TPR repeat-containing protein Y89_0022 ENOG4105C1A potassium transporter peripheral membrane Y89_0023 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Y89_0025 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Y89_0026 ENOG4108WZM domain protein Y89_0027 ENOG4105C79 DNA protecting protein DprA Y89_0029 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Y89_0031 ENOG4105E2X shikimate dehydrogenase Y89_0033 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase Y89_0037 ENOG4105CBG Sulfatase Y89_0038 ENOG4105ETT transcriptional Regulator, LysR family Y89_0041 ENOG4107ZHV Transcriptional regulator Y89_0042 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Y89_0043 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Y89_0044 ENOG4108MGI Transcriptional regulator Y89_0045 ENOG4105WKW Pfam:DUF1458 Y89_0047 ENOG4105D5K Hemolysin activator protein Y89_0048 ENOG4105CKT filamentous hemagglutinin Y89_0048 ENOG4105CKT filamentous hemagglutinin Y89_0053 ENOG4107PU6 Membrane Y89_0054 ENOG41072JS exoenzyme T Y89_0055 ENOG4106B0W Curli production assembly transport component CsgG Y89_0057 ENOG4107Y60 (LipO)protein Y89_0059 ENOG4105NGS secreted protein Y89_0062 ENOG4105CAQ asparagine synthetase Y89_0064 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) Y89_0066 ENOG4105CC0 LysR family Transcriptional regulator Y89_0069 ENOG4108Z9K Osmotically inducible protein Y89_0070 ENOG4105KBG Protein of unknown function (DUF1161) Y89_0075 ENOG4107XGZ Hydrolase Y89_0076 ENOG4108Z0R Transferase Y89_0077 ENOG4105DGW oligopeptidase A Y89_0078 ENOG4105VKU nucleicacid-binding protein Y89_0081 ENOG4105E6M Sulphatase-modifying factor protein Y89_0083 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y89_0084 ENOG4105D9P serine threonine protein kinase Y89_0085 ENOG4108ZF3 Phosphatase Y89_0088 ENOG4105ER2 Ompa motb domain protein Y89_0095 ENOG4108WC9 type VI secretion system effector, hcp1 family Y89_0100 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_0106 ENOG4105CS6 Rhs element vgr protein Y89_0113 ENOG4107B2H carbonic anhydrase Y89_0114 ENOG4105CHH sulfate transporter Y89_0117 ENOG4105BZ9 Cytochrome C oxidase, subunit I Y89_0118 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) Y89_0119 ENOG4107QS1 Cytochrome C Oxidase, Subunit III Y89_0126 ENOG4107YB6 acetyltransferase, (GNAT) family Y89_0127 ENOG4107YPT transcriptional regulator Y89_0130 ENOG4105CK2 sodium dicarboxylate symporter Y89_0134 ENOG4105CR8 Transcriptional regulator Y89_0139 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Y89_0140 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Y89_0143 ENOG4105C26 Dehydrogenase Y89_0144 ENOG4105K8K Cupin 2, conserved barrel Y89_0145 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Y89_0146 ENOG4105EVZ LysR family transcriptional regulator Y89_0147 ENOG4107QUY Guanine deaminase Y89_0149 ENOG4105C2J ABC transporter Y89_0150 ENOG4105UIB (ABC) transporter Y89_0153 ENOG4108JU3 Alkyl hydroperoxide reductase Y89_0154 ENOG4105CSR polyphosphate kinase 2 Y89_0155 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Y89_0165 ENOG4105DDW LysR family Transcriptional regulator Y89_0166 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta Y89_0167 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha Y89_0168 ENOG4107HP6 Transcriptional regulator Y89_0171 ENOG4105BZS acriflavin resistance protein Y89_0172 ENOG4105CC0 LysR family Transcriptional regulator Y89_0174 ENOG4105J5J Outer membrane porin Y89_0176 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Y89_0178 ENOG4105C2W permease Y89_0179 ENOG4108R86 Transcriptional regulator Y89_0181 ENOG4105BZU Histidine kinase Y89_0185 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Y89_0186 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Y89_0187 ENOG4105BZU Histidine kinase Y89_0188 ENOG4105C8Q Methyl-accepting chemotaxis Y89_0189 ENOG4108V3W Chemotaxis protein, CheW Y89_0190 ENOG4105CBS Chea signal transduction histidine kinase Y89_0191 ENOG4108VYJ response regulator receiver protein Y89_0193 ENOG4105EJC lysr family transcriptional regulator Y89_0194 ENOG4105F6U Short-chain dehydrogenase reductase Sdr Y89_0195 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Y89_0196 ENOG4105E2Y ABC, transporter Y89_0197 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Y89_0198 ENOG4107Z6I Thiamine biosynthesis protein Y89_0201 ENOG4105J5J Outer membrane porin Y89_0206 ENOG4105E2B Taurine dioxygenase Y89_0207 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Y89_0208 ENOG4105W8H transhydrogenase (subunit alpha Y89_0209 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Y89_0210 ENOG4105WQ5 TonB family Y89_0212 ENOG4105SG9 biopolymer transport protein, ExbD Y89_0220 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase Y89_0221 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Y89_0224 ENOG4108K70 Transcriptional regulator Y89_0226 ENOG4105C26 Dehydrogenase Y89_0227 ENOG4105C85 amino acid Y89_0228 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Y89_0230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Y89_0231 ENOG4107W7X Aldolase Y89_0235 ENOG4105CHU acetyl-coa acetyltransferase Y89_0236 ENOG4105CSH Transporter Y89_0237 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Y89_0238 ENOG4105F2Z 3-oxoadipate enol-lactonase Y89_0239 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Y89_0242 ENOG4105D2S major facilitator superfamily Y89_0244 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Y89_0247 ENOG41090KI Outer membrane porin Y89_0249 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Y89_0250 ENOG4108W9H Tetr family transcriptional regulator Y89_0251 ENOG4107S9B Shikimate dehydrogenase Y89_0252 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Y89_0253 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y89_0254 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase Y89_0257 ENOG4105CJW magnesium transporter Y89_0260 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes Y89_0261 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Y89_0270 ENOG4105CS6 Rhs element vgr protein Y89_0271 ENOG4108WC9 type VI secretion system effector, hcp1 family Y89_0282 ENOG4105DFP Integrase Y89_0283 ENOG4105C26 Dehydrogenase Y89_0284 ENOG4108JPW Aminotransferase Y89_0285 ENOG4108VYJ response regulator receiver protein Y89_0287 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Y89_0290 ENOG4105G2Y Transcriptional regulator Y89_0291 ENOG4105DJ2 Major Facilitator Superfamily Y89_0295 ENOG4108K0D peptidase, M48 Y89_0298 ENOG4108IJ6 ABC transporter Y89_0299 ENOG4105ECW sulfate abc transporter Y89_0300 ENOG4108I5D sulfate abc transporter Y89_0301 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Y89_0303 ENOG4105BZU Histidine kinase Y89_0306 ENOG4105CYW agmatinase Y89_0307 ENOG4105EVZ LysR family transcriptional regulator Y89_0308 ENOG4105BZU Histidine kinase Y89_0309 ENOG41090KI Outer membrane porin Y89_0313 ENOG4107RUE extracellular solute-binding protein family 1 Y89_0314 ENOG4105CFQ glutamine synthetase Y89_0315 ENOG4108Z86 Glutamine amidotransferase Y89_0316 ENOG4105CFQ glutamine synthetase Y89_0317 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Y89_0319 ENOG4108HM4 ABC transporter Y89_0320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y89_0321 ENOG4105F38 ABC transporter, permease Y89_0322 ENOG4105D38 putrescine abc transporter Y89_0333 ENOG4105E5Q amino acid AbC transporter Y89_0336 ENOG4108JQ1 Dehydrogenase Y89_0337 ENOG4105CQB FAD linked oxidase domain protein Y89_0338 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase Y89_0340 ENOG4105H4F exported protein Y89_0341 ENOG41067B5 Histone deacetylase superfamily protein Y89_0342 ENOG4105CUB amino acid Y89_0343 ENOG4107FKK extracellular solute-binding protein family 1 Y89_0344 ENOG4105D38 putrescine abc transporter Y89_0345 ENOG4105F38 ABC transporter, permease Y89_0346 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y89_0347 ENOG4108ZK4 sdia-regulated domain-containing protein Y89_0348 ENOG4108MXK alkaline phosphatase isozyme conversion Y89_0349 ENOG4105KWI UPF0339 protein Y89_0351 ENOG4105C7B Threonine dehydratase Y89_0353 ENOG4105CGD Nad-dependent epimerase dehydratase Y89_0358 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase Y89_0359 ENOG4105BZU Histidine kinase Y89_0361 ENOG4105HF0 Membrane Y89_0368 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Y89_0372 ENOG4108RE9 Phosphodiesterase Y89_0373 ENOG4105C2W permease Y89_0375 ENOG4105DR4 Methyltransferase Y89_0376 ENOG4107RKG DJ-1/PfpI family Y89_0383 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding Y89_0387 ENOG4107RGH Aldehyde dehydrogenase Y89_0390 ENOG4105DNZ Alpha Beta Hydrolase Y89_0392 ENOG4106H78 methyltransferase Y89_0395 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Y89_0396 ENOG4105CAK Cell division ATP-binding protein ftsE Y89_0397 ENOG4105CRP Part of the ABC transporter FtsEX involved in Y89_0398 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y89_0400 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Y89_0402 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Y89_0404 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Y89_0405 ENOG4105D25 secreted protein Y89_0408 ENOG4105CSA Coproporphyrinogen iii oxidase Y89_0409 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Y89_0411 ENOG4105DWV Homoserine O-trans-acetylase Y89_0413 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Y89_0414 ENOG4105VZ9 UPF0235 protein Y89_0415 ENOG4108VIA integral membrane protein Y89_0416 ENOG4105II7 pyrroline-5-carboxylate reductase Y89_0417 ENOG4105DFA alanine racemase domain protein Y89_0418 ENOG4105CZX twitching motility protein Y89_0419 ENOG4105CZX twitching motility protein Y89_0423 ENOG4105C28 cystathionine Y89_0424 ENOG4105CD3 dihydroorotase Y89_0430 ENOG4105D7Z glutathione synthase Y89_0431 ENOG4108UNF response regulator Y89_0433 ENOG4108ZGA chew protein Y89_0434 ENOG4105C8Q Methyl-accepting chemotaxis Y89_0435 ENOG4105BZU Histidine kinase Y89_0436 ENOG4105CBS Chea signal transduction histidine kinase Y89_0442 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Y89_0445 ENOG4105DS1 cytochrome b561 Y89_0447 ENOG4107MHI Transcriptional regulator, MarR family Y89_0448 ENOG4105C1P efflux transporter, rnd family, mfp subunit Y89_0449 ENOG4105BZS acriflavin resistance protein Y89_0450 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_0451 ENOG4105C1J atp-dependent rna helicase Y89_0453 ENOG4105SYT Methylenetetrahydrofolate reductase Y89_0457 ENOG4105CNM Receptor Y89_0459 ENOG4108R86 Transcriptional regulator Y89_0460 ENOG4105DZC cytosine deaminase Y89_0461 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin Y89_0462 ENOG4107SJI Dehydrogenase Y89_0463 ENOG4105BZ8 glutamate synthase Y89_0464 ENOG4105CD3 dihydroorotase Y89_0465 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Y89_0466 ENOG4105CE7 Amidase, hydantoinase carbamoylase family Y89_0468 ENOG4105C1G acyl-Coa dehydrogenase Y89_0469 ENOG4105ETT transcriptional Regulator, LysR family Y89_0471 ENOG4105CJ3 phosphate transporter Y89_0473 ENOG4107QX8 SPFH domain, Band 7 family protein Y89_0475 ENOG4105EM2 membrane Y89_0476 ENOG4105C1J atp-dependent rna helicase Y89_0477 ENOG4105VEQ Cold shock protein Y89_0478 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Y89_0479 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y89_0480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_0482 ENOG4106HNH Acyl-transferase Y89_0484 ENOG4105E3W Two component transcriptional regulator (Winged helix family Y89_0485 ENOG4105EB3 Histidine kinase Y89_0486 ENOG4105CT7 inner membrane cred family protein Y89_0491 ENOG4105E0K tonB-dependent siderophore receptor Y89_0492 ENOG4108S3W Anti-feci sigma factor, fecr Y89_0493 ENOG4108SF5 RNA Polymerase Y89_0494 ENOG4108U78 Glutathione S-transferase Y89_0495 ENOG41060I7 thioesterase Superfamily protein Y89_0496 ENOG4105J7D transcriptional regulator Y89_0497 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Y89_0501 ENOG4105F2Z 3-oxoadipate enol-lactonase Y89_0507 ENOG4105FR1 rard protein Y89_0508 ENOG4105E27 serine threonine protein kinase Y89_0509 ENOG4105F4R Transcriptional regulator mode Y89_0510 ENOG4105T42 (LipO)protein Y89_0511 ENOG4105MJ2 Competence protein Y89_0514 ENOG4105E7W lamb ycsf family protein Y89_0515 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Y89_0516 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Y89_0520 ENOG4105GQR Chaperone Y89_0523 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Y89_0525 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Y89_0527 ENOG4105CSU acyl-Coa dehydrogenase Y89_0528 ENOG4105CSU acyl-Coa dehydrogenase Y89_0529 ENOG4105CSU acyl-Coa dehydrogenase Y89_0531 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y89_0533 ENOG4108UMR transcriptional regulator AsnC family Y89_0534 ENOG4108ZGY Transcriptional regulator (AsnC family) Y89_0535 ENOG4108UMR transcriptional regulator AsnC family Y89_0536 ENOG4108ZGY Transcriptional regulator (AsnC family) Y89_0537 ENOG4106P6N cytochrome d1 heme region Y89_0538 ENOG4105Y7H Cytochrome Y89_0539 ENOG4105W2Z cytochrome C, class I Y89_0540 ENOG4105F64 nitrite reductase Y89_0541 ENOG4105GMT ATPase associated with various cellular activities aaa_5 Y89_0544 ENOG4108VKQ nitriC oxide reductase Y89_0546 ENOG4105FAE von Willebrand factor, type A Y89_0548 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Y89_0549 ENOG4105DND Transcriptional regulator Y89_0550 ENOG4108RPX mosc domain containing protein Y89_0552 ENOG4105C8Y Acetylornithine aminotransferase Y89_0553 ENOG41089BK Glutamine amido-transferase Y89_0555 ENOG4108UDW Transcriptional regulator, luxr family Y89_0556 ENOG4105CJP fad dependent oxidoreductase Y89_0558 ENOG4105HA9 of methanol dehydrogenase type Y89_0569 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Y89_0570 ENOG4105CV1 Transketolase (EC 2.2.1.1) Y89_0572 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Y89_0573 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Y89_0577 ENOG4105D2N Aldolase Y89_0581 ENOG4105CBX hi0933 family Y89_0583 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 Y89_0584 ENOG4105KAF membrAne Y89_0585 ENOG4105E7U AraC family transcriptional regulator Y89_0592 ENOG4107H8F Y89_0593 ENOG4108UNC Y89_0596 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Y89_0601 ENOG4105F9F transposase Y89_0621 ENOG4105KUS lysozyme Y89_0646 ENOG4105EKQ RNA-directed DNA polymerase Y89_0647 ENOG4105BZU Histidine kinase Y89_0648 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y89_0649 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Y89_0651 ENOG4105VCC 30S ribosomal protein S21 Y89_0654 ENOG4107ZVW dihydroneopterin aldolase Y89_0658 ENOG4105ED1 spovr family Y89_0660 ENOG4105CYN Serine protein kinase Y89_0664 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Y89_0665 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Y89_0666 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Y89_0667 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Y89_0668 ENOG4105EKQ RNA-directed DNA polymerase Y89_0670 ENOG4105EHM Aminoglycoside phosphotransferase Y89_0671 ENOG4108S0S Nucleotidyl transferase Y89_0672 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) Y89_0675 ENOG4105WH1 Two component transcriptional regulator luxr family Y89_0677 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y89_0679 ENOG4105F38 ABC transporter, permease Y89_0681 ENOG4105DJV ribulose-phosphate 3-epimerase Y89_0682 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Y89_0683 ENOG4105CRQ synthase (Component I) Y89_0685 ENOG4108XTP Transcriptional regulator Y89_0703 ENOG4105NVB glycoside hydrolase, family 19 Y89_0722 ENOG4105DDQ anthranilate synthase Y89_0725 ENOG4107RYR Transcriptional regulator, Crp Fnr family Y89_0726 ENOG4108UKZ OsmC family Y89_0729 ENOG4107YU2 histidine triad (hIT) protein Y89_0731 ENOG4108W6C Dehydrogenase Y89_0734 ENOG4108YXA Membrane Y89_0735 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Y89_0739 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Y89_0740 ENOG4105DR5 peptidase Y89_0741 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Y89_0742 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Y89_0747 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Y89_0756 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Y89_0779 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Y89_0782 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Y89_0786 ENOG4105CH6 catalase Y89_0787 ENOG4108UWD Iron-storage protein Y89_0788 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Y89_0789 ENOG4107RDB Major Facilitator Y89_0790 ENOG4108UUM single-stranded DNA-binding protein Y89_0791 ENOG4105E4F Isochorismate synthase Y89_0792 ENOG4105VIA Chorismate mutase Y89_0794 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Y89_0795 ENOG4105WPR Transcriptional regulator, ARAC family Y89_0796 ENOG4105C0W non-ribosomal peptide synthetase Y89_0797 ENOG4105C0W non-ribosomal peptide synthetase Y89_0801 ENOG4105CNM Receptor Y89_0803 ENOG4108VN5 Inherit from COG: PepSY-associated TM helix Y89_0805 ENOG41061H0 Monooxygenase Y89_0807 ENOG4105JAB phenazine biosynthesis protein, phzf family Y89_0811 ENOG4106SDP Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control Y89_0813 ENOG4107WY9 o-methyltransferase Y89_0814 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_0815 ENOG4105BZS acriflavin resistance protein Y89_0816 ENOG4105ENT Efflux transporter rnd family, mfp subunit Y89_0818 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Y89_0819 ENOG4105EGI Transcriptional regulator Y89_0820 ENOG4107QWG 2-Nitropropane dioxygenase Y89_0821 ENOG4105CPF Cell wall formation (By similarity) Y89_0822 ENOG4105C8F Beta-lactamase domain protein Y89_0823 ENOG4105CSU acyl-Coa dehydrogenase Y89_0825 ENOG4105BZU Histidine kinase Y89_0826 ENOG4108ZXC Two component transcriptional regulator, luxr family Y89_0827 ENOG4107UBR Extracellular solute-binding protein family 3 Y89_0828 ENOG4105EAD ABC transporter Y89_0829 ENOG4105DRP amino acid AbC transporter Y89_0833 ENOG4105C26 Dehydrogenase Y89_0834 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Y89_0835 ENOG4105C54 Major Facilitator superfamily Y89_0838 ENOG4105ECQ AraC Family Transcriptional Regulator Y89_0842 ENOG4105C7K acetolactate synthase Y89_0843 ENOG41090KI Outer membrane porin Y89_0846 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Y89_0847 ENOG4108MHS Lysyl endopeptidase Y89_0849 ENOG4108UQ8 endoribonuclease L-psp Y89_0851 ENOG4107RKG DJ-1/PfpI family Y89_0852 ENOG4105CAY ferredoxin--nadp reductase Y89_0853 ENOG41062ES Transcriptional regulator Y89_0854 ENOG4105CNM Receptor Y89_0855 ENOG4105CV8 reductase Y89_0859 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Y89_0860 ENOG4105CHR reductase Y89_0861 ENOG4105TVJ transport system, permease Y89_0862 ENOG4105DQ5 transport system permease protein Y89_0863 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein Y89_0864 ENOG4105E0A ABC, transporter Y89_0866 ENOG4107RBR Receptor Y89_0867 ENOG4105CPU Monooxygenase Y89_0868 ENOG4106MWK domain protein Y89_0870 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 Y89_0871 ENOG4105CPP Dehydrogenase, E1 component Y89_0873 ENOG4106Z86 ATP-nad acox kinase Y89_0874 ENOG4105CHR reductase Y89_0875 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Y89_0879 ENOG4108JJA ABC, transporter Y89_0880 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Y89_0885 ENOG4105EPF Outer membrane porin Y89_0886 ENOG4105C2C drug resistance transporter, Bcr CflA Y89_0887 ENOG4108V8F Transcriptional regulator, MarR family Y89_0889 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Y89_0890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y89_0892 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Y89_0896 ENOG4105CSP Major Facilitator Superfamily Y89_0898 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase Y89_0899 ENOG4105C26 Dehydrogenase Y89_0905 ENOG4105BZU Histidine kinase Y89_0907 ENOG4105EWT decarboxylase family Y89_0909 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) Y89_0910 ENOG4105BZU Histidine kinase Y89_0912 ENOG41066YJ Beta-lactamase Y89_0913 ENOG4105ETT transcriptional Regulator, LysR family Y89_0915 ENOG4105CPI Metal Dependent Phosphohydrolase Y89_0917 ENOG4105E18 UPF0276 protein Y89_0919 ENOG4109045 doxx family Y89_0921 ENOG4105E0F Histidine kinase Y89_0922 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Y89_0926 ENOG4105CHR reductase Y89_0928 ENOG4108I5G Major Facilitator superfamily Y89_0932 ENOG4107UWN reductase Y89_0933 ENOG4105EFA 4-hydroxyphenylacetate Y89_0935 ENOG4105CHR reductase Y89_0936 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Y89_0939 ENOG4105GQR Chaperone Y89_0940 ENOG4105CW0 outer membrane usher protein Y89_0944 ENOG41068CG regulatoR Y89_0945 ENOG4108RU0 short-chain dehydrogenase reductase Y89_0952 ENOG4105CUB amino acid Y89_0954 ENOG4105E7U AraC family transcriptional regulator Y89_0956 ENOG4105C1B dTDP-glucose 4-6-dehydratase Y89_0957 ENOG4108YY7 Invasion gene expression up-regulator SirB Y89_0958 ENOG4105EIF outer membrane protein W Y89_0964 ENOG4107QR8 Thioredoxin Y89_0965 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Y89_0968 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Y89_0970 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Y89_0972 ENOG4107YIM Involved in the transcription termination process (By similarity) Y89_0973 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Y89_0974 ENOG4108ZAI phosphatidylglycerophosphatase a Y89_0976 ENOG4108WIW Aspartyl protease Y89_0979 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Y89_0981 ENOG4105CTB Polyprenyl synthetase Y89_0983 ENOG4105CMJ mandelate racemase muconate lactonizing Y89_0987 ENOG4105CJ1 ABC, transporter Y89_0988 ENOG4105BZU Histidine kinase Y89_0990 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Y89_0992 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Y89_0993 ENOG4105F0N pyrophosphate phospho-hydrolase Y89_0994 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) Y89_0995 ENOG4105DQR SNARE associated Golgi Y89_0998 ENOG4105KD7 acetyltransferase Y89_1000 ENOG4105CPD ethanolamine ammonia-lyase Y89_1001 ENOG4105CUB amino acid Y89_1002 ENOG4105C26 Dehydrogenase Y89_1003 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Y89_1004 ENOG4105DFU Cell wall formation (By similarity) Y89_1005 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Y89_1007 ENOG4105K4T epimerase Y89_1011 ENOG41067MG lrgb family Y89_1013 ENOG4108KF1 Membrane Y89_1021 ENOG4105CJN penicillin-binding protein Y89_1022 ENOG4105CNI cell division protein FtsW Y89_1023 ENOG4105CVE Lytic murein transglycosylase Y89_1024 ENOG4105K6T rare lipoprotein A Y89_1025 ENOG4105DZ1 carboxypeptidase Y89_1029 ENOG4105EXG Transcriptional regulator Y89_1031 ENOG4105CVE Lytic murein transglycosylase Y89_1035 ENOG4105C8T Leucyl-tRNA synthetase Y89_1037 ENOG41080C8 DUF218 domain Y89_1038 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Y89_1039 ENOG4108JU5 Magnesium and cobalt efflux protein Y89_1041 ENOG4105C9A Phoh family Y89_1046 ENOG4107S5G Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Y89_1047 ENOG4105DWF phosphomethylpyrimidine kinase Y89_1048 ENOG4105BZU Histidine kinase Y89_1050 ENOG4105CSU acyl-Coa dehydrogenase Y89_1052 ENOG4105FYV Amp nucleosidase Y89_1055 ENOG4108R99 pseudouridine synthase Y89_1058 ENOG4105EW9 transcriptional regulator AsnC family Y89_1060 ENOG41076HS cation diffusion facilitator family transporter Y89_1062 ENOG4105CQ7 ATP-dependent helicase Y89_1069 ENOG4105FBW Monooxygenase Y89_1071 ENOG4105G4C Periplasmic ligand-binding sensor protein Y89_1073 ENOG4105C1J atp-dependent rna helicase Y89_1074 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_1075 ENOG4108WQH regulatoR Y89_1076 ENOG4105BZU Histidine kinase Y89_1077 ENOG4105BZU Histidine kinase Y89_1078 ENOG4108YYQ gCN5-related N-acetyltransferase Y89_1079 ENOG4108YYQ gCN5-related N-acetyltransferase Y89_1081 ENOG4105C29 acyl-CoA thioesterase Y89_1085 ENOG4106FTQ Taurine ABC transporter, periplasmic Y89_1087 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Y89_1088 ENOG4105E2B Taurine dioxygenase Y89_1089 ENOG4105EPD Oligopeptide transporter, Opt family Y89_1090 ENOG4105C94 Transporter Y89_1092 ENOG4105D01 (LipO)protein Y89_1093 ENOG4105C4M (Ubiquinol oxidase) subunit I Y89_1094 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Y89_1096 ENOG4105R1U AraC Family Transcriptional Regulator Y89_1098 ENOG4105CHU acetyl-coa acetyltransferase Y89_1099 ENOG4105CEY Amp-dependent synthetase and ligase Y89_1101 ENOG4105D25 secreted protein Y89_1104 ENOG4108IAB Phoh family Y89_1106 ENOG4105M00 molybdopterin converting factor, subunit 1 Y89_1107 ENOG4108ZAF Molybdopterin Y89_1108 ENOG4108RIR Molybdenum cofactor biosynthesis protein Y89_1109 ENOG4105CVM Molybdenum cofactor synthesis domain protein Y89_1110 ENOG4105CFP Peptidase U32 Y89_1111 ENOG4106RZ4 Peptidase U32 Y89_1112 ENOG4105XPQ lipid carrier protein Y89_1121 ENOG4108ZGU inhibitor of vertebrate lysozyme Y89_1122 ENOG4105GAV receptor Y89_1123 ENOG4108S3W Anti-feci sigma factor, fecr Y89_1124 ENOG4108SF5 RNA Polymerase Y89_1125 ENOG4105ECQ AraC Family Transcriptional Regulator Y89_1126 ENOG4108Q5Y Membrane Y89_1127 ENOG4105C5I Dehydrogenase Y89_1128 ENOG4105CC0 LysR family Transcriptional regulator Y89_1132 ENOG4105Y49 secretion protein, HlyD family Y89_1133 ENOG4108IJ8 ABC transporter Y89_1134 ENOG4105E90 ABC transporter Y89_1135 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system Y89_1136 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component Y89_1137 ENOG4105EEQ Na H antiporter Y89_1143 ENOG4105E1F short-chain dehydrogenase reductase Y89_1147 ENOG4105WH1 Two component transcriptional regulator luxr family Y89_1148 ENOG4105BZU Histidine kinase Y89_1150 ENOG4105DQQ Major facilitator superfamily MFS_1 Y89_1151 ENOG4105CRU nitrate reductase, alpha subunit Y89_1152 ENOG4108IUE nitrate reductase beta subunit Y89_1153 ENOG4105R3A Nitrate reductase Y89_1154 ENOG4105D0D Nitrate reductase 2, gamma subunit Y89_1155 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Y89_1156 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Y89_1158 ENOG4105D05 Receptor Y89_1159 ENOG4105E89 ABC transporter Y89_1160 ENOG4108SGR YheO domain-containing protein Y89_1161 ENOG4105FC8 fad dependent oxidoreductase Y89_1164 ENOG4105CEY Amp-dependent synthetase and ligase Y89_1167 ENOG4105VE1 Phosphatidylcholine synthase Y89_1179 ENOG4105ETT transcriptional Regulator, LysR family Y89_1183 ENOG41072JS exoenzyme T Y89_1185 ENOG4107QWE )-transporter Y89_1186 ENOG4105D5T phosphonate abc transporter Y89_1187 ENOG4105C7J ABC transporter, permease Y89_1192 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Y89_1194 ENOG4105MYG DNA polymerase iii, chi subunit Y89_1196 ENOG4108ZX5 transcriptional regulator Y89_1198 ENOG4108M8S permease YjgP YjgQ family protein Y89_1199 ENOG4108K5H permease YjgP YjgQ family protein Y89_1201 ENOG4105BZU Histidine kinase Y89_1202 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Y89_1204 ENOG4105VIE preprotein translocase, subunit YajC Y89_1205 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Y89_1206 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Y89_1207 ENOG4107MBR 17 kDa surface antigen Y89_1208 ENOG4105ECY inositol monophosphatase Y89_1210 ENOG4105D7W serine acetyltransferase Y89_1211 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Y89_1213 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Y89_1214 ENOG4108Z4V iron-sulfur cluster assembly Y89_1216 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB Y89_1217 ENOG4108ZIT Ferredoxin, 2FE-2S Y89_1218 ENOG4105WVQ Fe-S assembly protein IscX Y89_1226 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Y89_1228 ENOG4105CHM Aminotransferase Y89_1231 ENOG4105CPC Aldo Keto reductase Y89_1234 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Y89_1236 ENOG4107RNH Outer membrane receptor FepA Y89_1239 ENOG4105DR5 peptidase Y89_1241 ENOG41080T7 secreted protein Y89_1243 ENOG4108RWI nicotinamidase Y89_1244 ENOG4105ECQ AraC Family Transcriptional Regulator Y89_1246 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Y89_1248 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Y89_1249 ENOG4108M0I Transcriptional regulator Y89_1250 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Y89_1253 ENOG4105DGU Histone deacetylase Y89_1257 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Y89_1259 ENOG4107R16 Multicopper oxidase Y89_1260 ENOG4108Z6B deaminase Y89_1263 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Y89_1264 ENOG4108ETH Formylglycinamide ribotide synthetase Y89_1266 ENOG4105CI1 PTS System Y89_1267 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Y89_1268 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Y89_1269 ENOG4105CE4 GlcNAc 6-P deacetylase Y89_1270 ENOG4105FDP GntR family transcriptional regulator Y89_1272 ENOG4105E09 nadh pyrophosphatase Y89_1273 ENOG4105P8F nudix hydrolase Y89_1274 ENOG4108Z0R Transferase Y89_1278 ENOG4105CSH Transporter Y89_1279 ENOG4108JU6 CBS domain protein Y89_1281 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Y89_1289 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y89_1290 ENOG4105T95 Thiol disulfide interChange protein Y89_1292 ENOG4105D6E homoserine dehydrogenase Y89_1293 ENOG4105D98 threonine synthase Y89_1296 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Y89_1301 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Y89_1303 ENOG4108VWS Yaeq family Y89_1304 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Y89_1305 ENOG4105D4Y metalloprotease Y89_1312 ENOG41068CG regulatoR Y89_1315 ENOG4108KSA LysR family transcriptional regulator Y89_1317 ENOG4105CSH Transporter Y89_1320 ENOG4108KTQ Methyltransferase Y89_1322 ENOG4105CBS Chea signal transduction histidine kinase Y89_1323 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Y89_1325 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Y89_1331 ENOG4105EUK rtx toxin RtxA Y89_1333 ENOG4108UVJ appr-1-p processing domain protein Y89_1334 ENOG4105KCK Peptidoglycan-associated lipoprotein Y89_1337 ENOG4105W1Y Transcriptional regulator Y89_1339 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Y89_1341 ENOG41072GX Peptidase M22 Glycoprotease Y89_1343 ENOG41081XQ Conserved Protein Y89_1344 ENOG4105CR4 methylisocitrate lyase Y89_1346 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) Y89_1349 ENOG4105DJY efflux transporter, rnd family, mfp subunit Y89_1358 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Y89_1359 ENOG4105C9B Cysteine desulfurase Y89_1360 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) Y89_1362 ENOG4105KUZ arsenate reductase Y89_1366 ENOG4105EEQ Na H antiporter Y89_1367 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) Y89_1368 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Y89_1369 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Y89_1374 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Y89_1375 ENOG4105KNE Phosphatidate cytidylyltransferase Y89_1377 ENOG4105DZP Membrane-associated zinc metalloprotease Y89_1378 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Y89_1379 ENOG4105X4K outer membrane chaperone skp Y89_1385 ENOG4105BZG amino acid carrier protein Y89_1386 ENOG4105C0B DNA polymerase III (alpha subunit) Y89_1388 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Y89_1392 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Y89_1393 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Y89_1395 ENOG41066VF YeeE YedE family protein Y89_1396 ENOG4105CC0 LysR family Transcriptional regulator Y89_1398 ENOG4105C4W S-formylglutathione hydrolase Y89_1400 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Y89_1403 ENOG4108K5P (LipO)protein Y89_1404 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y89_1405 ENOG4108Z4U Ferredoxin Y89_1406 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Y89_1408 ENOG4107TH8 cina domain protein Y89_1410 ENOG4105Y3E Modulates RecA activity (By similarity) Y89_1412 ENOG4105CY0 Metallo-Beta-Lactamase Y89_1413 ENOG4107QRI Phosphoketolase Y89_1414 ENOG4105VRT cytoplasmic protein Y89_1417 ENOG4105D38 putrescine abc transporter Y89_1418 ENOG4105F38 ABC transporter, permease Y89_1419 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y89_1420 ENOG4106IUH DTW domain containing protein Y89_1423 ENOG41080IJ Diacylglycerol kinase Y89_1424 ENOG4105CBC glutamate synthase Y89_1429 ENOG4105CUB amino acid Y89_1430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Y89_1431 ENOG4105CSH Transporter Y89_1432 ENOG4105CN8 Transcriptional regulator Y89_1433 ENOG4105CSU acyl-Coa dehydrogenase Y89_1434 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Y89_1435 ENOG4105E39 Enoyl-CoA hydratase Y89_1436 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y89_1437 ENOG4105CHU acetyl-coa acetyltransferase Y89_1438 ENOG41090KI Outer membrane porin Y89_1439 ENOG4105DZ2 Transcriptional regulator Y89_1441 ENOG4105RA2 Membrane Y89_1442 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Y89_1443 ENOG4105E98 transcriptional regulator DeoR family Y89_1444 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Y89_1445 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Y89_1446 ENOG4108Z66 YbaK ebsC protein Y89_1447 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Y89_1448 ENOG4105JAB phenazine biosynthesis protein, phzf family Y89_1453 ENOG4105C2C drug resistance transporter, Bcr CflA Y89_1455 ENOG41063TF transcriptional regulator (AraC Y89_1456 ENOG4105C26 Dehydrogenase Y89_1457 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Y89_1458 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Y89_1461 ENOG4105CBN LysR family transcriptional regulator Y89_1463 ENOG4105EYA deoxyribonuclease Y89_1464 ENOG4107B7Y DNA-binding transcriptional regulator FruR Y89_1465 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Y89_1466 ENOG4105DE4 1-phosphofructokinase Y89_1467 ENOG4105DM4 PTS System Y89_1468 ENOG4105C6Y Udp-glucose 6-dehydrogenase Y89_1471 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Y89_1476 ENOG4105CJT Mannose-1-phosphate guanylyltransferase Y89_1477 ENOG4105ZJ4 Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate is important for the architecture of biofilms and increases Y89_1478 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate Y89_1479 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Y89_1481 ENOG4105JHR Alginate biosynthesis protein AlgX Y89_1482 ENOG4108C0K Bifunctional protein that converts poly(beta-D- mannuronate) to alpha-L-guluronate and that is also part of a periplasmic protein complex that serves as a scaffold that leads the newly formed alginate polymer through the periplasmic space to the outer membrane secretin AlgE Y89_1483 ENOG4105Y9T outer membrane protein AlgE Y89_1484 ENOG4105XJP alginate biosynthesis protein Y89_1485 ENOG4108UIA Alginate biosynthesis protein Alg44 Y89_1486 ENOG4105KZJ alginate biosynthesis protein Alg8 Y89_1487 ENOG4105C6Y Udp-glucose 6-dehydrogenase Y89_1489 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y89_1490 ENOG4105DBV ornithine carbamoyltransferase Y89_1493 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Y89_1494 ENOG4105M2J Glutaredoxin Y89_1495 ENOG4106UW1 Major Facilitator superfamily Y89_1496 ENOG4108UQY Iron-storage protein Y89_1497 ENOG4105W53 bacterioferritin-associated ferredoxin Y89_1498 ENOG4105D3R alkyl hydroperoxide reductase Y89_1504 ENOG4105C1P efflux transporter, rnd family, mfp subunit Y89_1506 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_1510 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Y89_1511 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Y89_1512 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Y89_1514 ENOG4105CSM endonuclease III Y89_1529 ENOG4105VJY transcriptional regulator Y89_1530 ENOG4108MVS synthase Y89_1531 ENOG4105F87 Dehydratase Y89_1532 ENOG4105EMK carboxylate amino acid amine transporter Y89_1534 ENOG4105K4H Nlp p60 protein Y89_1535 ENOG4107R1I NAD-dependent malic enzyme Y89_1537 ENOG4105NAE bifunctional deaminase-reductase domain protein Y89_1538 ENOG4105CUY Mechanosensitive ion channel Y89_1539 ENOG41079KZ Major Facilitator Superfamily Y89_1540 ENOG4105C1J atp-dependent rna helicase Y89_1544 ENOG4105BZU Histidine kinase Y89_1545 ENOG4105DER m42 family Y89_1546 ENOG4107RRY Cyanophycin synthetase Y89_1547 ENOG4105CAQ asparagine synthetase Y89_1550 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Y89_1551 ENOG4105CSR polyphosphate kinase 2 Y89_1552 ENOG4105CHU acetyl-coa acetyltransferase Y89_1554 ENOG4105DWT malate dehydrogenase (quinone) Y89_1556 ENOG4105D3R alkyl hydroperoxide reductase Y89_1557 ENOG4105GVF (ABC) transporter Y89_1558 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Y89_1561 ENOG4105GVF (ABC) transporter Y89_1562 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Y89_1563 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Y89_1564 ENOG4105E2Y ABC, transporter Y89_1565 ENOG4105F4R Transcriptional regulator mode Y89_1568 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase Y89_1569 ENOG4105EUJ GTP cyclohydrolase i Y89_1570 ENOG410642E Short chain dehydrogenase Y89_1572 ENOG4105QDK Flavodoxin Y89_1573 ENOG4105EQR Transposase IS116 IS110 IS902 Y89_1574 ENOG4108KB2 LysR family Transcriptional regulator Y89_1575 ENOG4105VAW lrga family Y89_1576 ENOG41067MG lrgb family Y89_1577 ENOG4105MP9 class II Aldolase Y89_1580 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Y89_1581 ENOG4105E39 Enoyl-CoA hydratase Y89_1583 ENOG4105IQJ Involved in biosynthesis of the thiamine precursor thiazole (By similarity) Y89_1586 ENOG4105D25 secreted protein Y89_1588 ENOG41063JG Transcriptional regulator Y89_1590 ENOG4107RUY (E1 component), alpha subunit Y89_1591 ENOG4105CPP Dehydrogenase, E1 component Y89_1592 ENOG4105C7S Dehydrogenase Y89_1600 ENOG4105X58 receptor Y89_1602 ENOG4108JJ6 Type I secretion system ATPase Y89_1603 ENOG4107QZV Type I secretion membrane fusion protein Y89_1604 ENOG4105DFG type I secretion outer membrane protein Y89_1611 ENOG4105DUM transcriptional regulator, lysR family Y89_1612 ENOG4105DP0 ferredoxin-NADP reductase Y89_1614 ENOG4108T0W nitrous oxide maturation protein NosY Y89_1615 ENOG4105CIG ABC transporter Y89_1616 ENOG4105DH4 Periplasmic copper-binding protein Y89_1617 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) Y89_1618 ENOG4105HEE Binding Domain protein Y89_1621 ENOG4108R96 Methyltransferase, YaeB family Y89_1622 ENOG4105CHR reductase Y89_1626 ENOG4105EHI Phosphonate ABC transporter, periplasmic Y89_1628 ENOG4107RJJ Transcriptional regulator Y89_1631 ENOG4105EKV Phosphonate metabolism protein Y89_1632 ENOG4105FT8 Phosphonate metabolism Y89_1633 ENOG4105ENV phosphonate C-P lyase system protein PhnK Y89_1634 ENOG4105HRV phosphonate c-p lyase system protein phnl Y89_1635 ENOG4105FD8 phosphonate metabolism protein PhnM Y89_1637 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein Y89_1642 ENOG4105UPP uncharacterized protein ydcA Y89_1645 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein Y89_1646 ENOG4108S3N antar domain-containing protein Y89_1647 ENOG4105IW1 AmiS UreI transporter Y89_1651 ENOG4105FDR Membrane Y89_1656 ENOG4106825 Type iv pilus assembly Y89_1660 ENOG4107R88 Chemotaxis protein (CheV) Y89_1661 ENOG4105BZU Histidine kinase Y89_1663 ENOG4108KXV response regulator Y89_1665 ENOG4105C9U ATP-dependent DNA helicase RecQ Y89_1670 ENOG4105D78 K07001 NTE family protein Y89_1677 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein Y89_1678 ENOG4106A3M Cytochrome p-450 Y89_1679 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr Y89_1683 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Y89_1690 ENOG4105HSS phospholipase C Y89_1695 ENOG4105D5T phosphonate abc transporter Y89_1696 ENOG4107T9Q phosphonate abc transporter Y89_1697 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Y89_1698 ENOG4105BZU Histidine kinase Y89_1699 ENOG4105DIJ Phosphoethanolamine transferase Y89_1700 ENOG4107YZX Universal stress protein Y89_1701 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Y89_1709 ENOG4108SUT Major Facilitator Superfamily Y89_1710 ENOG4108Z7G MaoC domain protein dehydratase Y89_1711 ENOG4105E8V Alpha Beta Hydrolase Fold protein Y89_1712 ENOG4105CEY Amp-dependent synthetase and ligase Y89_1713 ENOG4105CEY Amp-dependent synthetase and ligase Y89_1715 ENOG4105CQ7 ATP-dependent helicase Y89_1717 ENOG4105K59 histidine triad (HIT) protein Y89_1724 ENOG4105JXB ankyrin repeat-containing protein Y89_1733 ENOG4108SDF phosphate-selective porin O and P Y89_1740 ENOG4107QRT dEAD DEAH box helicase Y89_1741 ENOG4105BZU Histidine kinase Y89_1744 ENOG4105GAV receptor Y89_1746 ENOG4105VEQ Cold shock protein Y89_1747 ENOG4105KPY Small multidrug resistance protein Y89_1748 ENOG4105C09 Bile acid Y89_1750 ENOG4108V1T peptidylprolyl cis-trans isomerase Y89_1756 ENOG4105BZU Histidine kinase Y89_1757 ENOG4105CN1 protease Y89_1758 ENOG4108JA1 polyketide synthase Y89_1759 ENOG4105EAC phosphoserine phosphatase Y89_1762 ENOG4105F38 ABC transporter, permease Y89_1766 ENOG4105D9U N-acetyltransferase Y89_1768 ENOG4105D3G Pseudouridine synthase Y89_1770 ENOG4107QMS site-determining protein Y89_1772 ENOG4105D1S lipid A biosynthesis Y89_1774 ENOG4105EUB pirin domain protein Y89_1775 ENOG410903C (LipO)protein Y89_1779 ENOG41062QD Membrane Y89_1780 ENOG4107QN1 sodium solute Y89_1784 ENOG4105EQR Transposase IS116 IS110 IS902 Y89_1787 ENOG4105BZ1 (ABC) transporter Y89_1788 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Y89_1789 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Y89_1792 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Y89_1794 ENOG4108Z7R Chaperone CsaA Y89_1797 ENOG4105BZF Glycosyl transferase (Group 1 Y89_1798 ENOG4105F8J Adenylate Guanylate cyclase Y89_1800 ENOG4108ZX5 transcriptional regulator Y89_1803 ENOG4105DHJ ABC, transporter Y89_1805 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Y89_1806 ENOG4105PI0 Ferredoxin Y89_1807 ENOG41069NU Nitroreductase Y89_1809 ENOG410804D Sensor Signal Transduction Histidine Kinase Y89_1811 ENOG4105E3W Two component transcriptional regulator (Winged helix family Y89_1813 ENOG4105K9H YciI-like protein Y89_1815 ENOG4105DB7 PHP domain protein Y89_1816 ENOG4107RTD sua5 ycio yrdc ywlc family protein Y89_1818 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Y89_1821 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Y89_1822 ENOG4105C01 Dihydroxy-acid dehydratase Y89_1824 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Y89_1825 ENOG4105E0F Histidine kinase Y89_1827 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Y89_1829 ENOG4108IJ9 (ABC) transporter Y89_1830 ENOG4105TW1 Carbohydrate-selective porin OprB Y89_1831 ENOG4105DSB aldose 1-epimerase Y89_1832 ENOG4106KNT transcriptional regulator Y89_1833 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Y89_1834 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Y89_1835 ENOG4108UHU Aldolase Y89_1837 ENOG4105FE9 pseudouridine synthase Y89_1839 ENOG4105BZU Histidine kinase Y89_1840 ENOG4105D6U Sodium Glutamate Symporter Y89_1843 ENOG4105UBK short-chain dehydrogenase reductase Y89_1844 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Y89_1846 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Y89_1848 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y89_1850 ENOG4105CQC Prephenate dehydratase Y89_1851 ENOG4105CIH Imidazole acetol-phosphate transaminase Y89_1852 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Y89_1854 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Y89_1857 ENOG4108IAJ Nad-dependent epimerase dehydratase Y89_1858 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Y89_1859 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase Y89_1860 ENOG4105D2T synthase Y89_1870 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Y89_1871 ENOG4108REZ Imidazole glycerol phosphate synthase Y89_1877 ENOG4105ESV Glycosyl transferase, family 4 Y89_1880 ENOG4105CGF Aromatic amino acid aminotransferase Y89_1881 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Y89_1884 ENOG4105HEI LysR family (Transcriptional regulator Y89_1885 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Y89_1887 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Y89_1888 ENOG4108UHU Aldolase Y89_1890 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Y89_1891 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Y89_1895 ENOG4105HEI LysR family (Transcriptional regulator Y89_1896 ENOG4105KME endoribonuclease L-psp Y89_1897 ENOG4108MP6 LysR family Transcriptional regulator Y89_1900 ENOG4105F2W methyltransferase Y89_1901 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Y89_1902 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Y89_1903 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Y89_1905 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Y89_1906 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Y89_1908 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Y89_1909 ENOG41063M6 Cell Division Protein Y89_1910 ENOG4105E96 Colicin v production protein Y89_1911 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Y89_1912 ENOG4105C28 cystathionine Y89_1913 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Y89_1914 ENOG4105GVR general secretion pathway protein D Y89_1915 ENOG4106I3Z Y89_1916 ENOG4107QHF type ii secretion system protein e Y89_1917 ENOG4105D7Q type ii secretion system Y89_1918 ENOG4108VAU general secretion pathway protein G Y89_1919 ENOG4105VWV general secretion pathway protein h Y89_1920 ENOG4105X5Z General secretion pathway protein I Y89_1921 ENOG4108WWZ General secretion pathway protein J Y89_1922 ENOG4108RTD type II secretion system protein K Y89_1923 ENOG4108ADH Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) Y89_1924 ENOG41064QQ General secretion pathway Y89_1925 ENOG4108ZX5 transcriptional regulator Y89_1927 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_1932 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Y89_1934 ENOG4105VUT cytoplasmic protein Y89_1936 ENOG4105CD8 aminopeptidase N Y89_1938 ENOG4105D25 secreted protein Y89_1941 ENOG4105US7 Histidine kinase Y89_1942 ENOG4105ETX regulatoR Y89_1949 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Y89_1951 ENOG4105C7I Dehydrogenase Y89_1953 ENOG4105D3W isochorismatase Y89_1955 ENOG4105GSQ TM1410 hypothetical-related protein Y89_1960 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Y89_1970 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) Y89_1971 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Y89_1972 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family Y89_1973 ENOG41090ED Protein with unknown function (DUF469) Y89_1974 ENOG4108WQH regulatoR Y89_1975 ENOG4105BZU Histidine kinase Y89_1981 ENOG4105EPF Outer membrane porin Y89_1982 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Y89_1985 ENOG4105J7D transcriptional regulator Y89_1990 ENOG4108RIR Molybdenum cofactor biosynthesis protein Y89_1991 ENOG4105CVM Molybdenum cofactor synthesis domain protein Y89_1994 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Y89_1995 ENOG4108CWB sugar kinase ygcE Y89_1996 ENOG4107TE5 Lipid kinase Y89_1999 ENOG4107SC1 transglycosylase Y89_2000 ENOG4105C5H ABC transporter Y89_2002 ENOG41081QV Universal stress protein Y89_2008 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Y89_2011 ENOG4106AIJ Cell Division Y89_2015 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Y89_2017 ENOG4108JA2 transcriptioN-repair coupling factor Y89_2019 ENOG4105C85 amino acid Y89_2020 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y89_2022 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y89_2025 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) Y89_2026 ENOG4105CJ2 (LipO)protein Y89_2029 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Y89_2032 ENOG4105D60 lipoprotein releasing system transmembrane protein Y89_2033 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Y89_2034 ENOG4105D60 lipoprotein releasing system transmembrane protein Y89_2036 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Y89_2038 ENOG4109015 Biopolymer transport protein exbD tolR Y89_2041 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Y89_2043 ENOG4105D4A Cell wall formation (By similarity) Y89_2044 ENOG4105C03 ribonuclease Y89_2045 ENOG4105EI2 Pseudouridine synthase Y89_2047 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Y89_2048 ENOG4108UHJ MAF-like protein Y89_2049 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein Y89_2052 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Y89_2053 ENOG4105CHR reductase Y89_2054 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Y89_2055 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y89_2057 ENOG4105HHA aminodeoxychorismate lyase Y89_2059 ENOG4107QRG dna polymerase iii Y89_2061 ENOG4105F8V Hydrolase, tatD family Y89_2062 ENOG4105C9B Cysteine desulfurase Y89_2067 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase Y89_2068 ENOG4105BZJ Electron transfer flavoprotein Y89_2069 ENOG4105C10 Electron transfer flavoprotein Y89_2072 ENOG4105CIA precorrin-4 C(11)-methyltransferase Y89_2073 ENOG4108P62 biosynthesis protein (CbiG) Y89_2076 ENOG4107QRP cobalamin biosynthesis protein CobW Y89_2077 ENOG4105CTK cobaltochelatase, cobn subunit Y89_2078 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Y89_2081 ENOG4105CHU acetyl-coa acetyltransferase Y89_2083 ENOG4105C2W permease Y89_2085 ENOG4105CPW cytochrome b561 Y89_2089 ENOG4105F27 Major Facilitator Y89_2090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_2091 ENOG4108IND Tetr family transcriptional regulator Y89_2092 ENOG4108MGI Transcriptional regulator Y89_2096 ENOG4108JEH abc transporter atp-binding protein Y89_2097 ENOG4106YG3 ABC transporter Y89_2098 ENOG4105DSP amino acid AbC transporter Y89_2099 ENOG4105E89 ABC transporter Y89_2100 ENOG4105CH2 amidohydrolase Y89_2101 ENOG4107F9Y LysR family transcriptional regulator Y89_2102 ENOG4105C8Q Methyl-accepting chemotaxis Y89_2108 ENOG4105DQ5 transport system permease protein Y89_2110 ENOG4105E0A ABC, transporter Y89_2115 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase Y89_2116 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Y89_2117 ENOG41081F0 Precorrin-8x methylmutase Y89_2118 ENOG4105DVK Precorrin-2 c20-methyltransferase Y89_2123 ENOG41068CG regulatoR Y89_2125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y89_2126 ENOG4108WQI RNA Polymerase Y89_2130 ENOG4105CHR reductase Y89_2132 ENOG4108IPT Naphthoate synthase Y89_2133 ENOG4105C1G acyl-Coa dehydrogenase Y89_2134 ENOG4107QX3 carboxylase Y89_2137 ENOG4108RZE Tetr family transcriptional regulator Y89_2141 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_2143 ENOG4105CWB LysR family transcriptional Regulator Y89_2145 ENOG4105CBN LysR family transcriptional regulator Y89_2147 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Y89_2149 ENOG4105F8C transglutaminase domain-containing protein Y89_2152 ENOG4105BZU Histidine kinase Y89_2157 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Y89_2158 ENOG4108VGI doxx family Y89_2159 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) Y89_2160 ENOG4107IFA Lipase (EC 3.1.1.3) Y89_2161 ENOG4107XID 2'-5' rna ligase Y89_2163 ENOG4108RRZ Transcription elongation factor GreB Y89_2164 ENOG4105CV6 ABC transporter, permease Y89_2165 ENOG4108I0Y (ABC) transporter Y89_2166 ENOG4108UJV acyl-CoA thioesterase i Y89_2168 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein Y89_2171 ENOG4108ZHJ Organic hydroperoxide resistance protein Y89_2172 ENOG4105K56 Transcriptional regulator Y89_2173 ENOG4105EJC lysr family transcriptional regulator Y89_2177 ENOG4105T0Z Conserved Protein Y89_2178 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Y89_2180 ENOG4105E39 Enoyl-CoA hydratase Y89_2182 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Y89_2186 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y89_2188 ENOG41068KF Universal stress protein Y89_2193 ENOG4105CHM Aminotransferase Y89_2196 ENOG4105K56 Transcriptional regulator Y89_2197 ENOG4105BZU Histidine kinase Y89_2198 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Y89_2199 ENOG4108ZGC gaf domain protein Y89_2200 ENOG4107MKT Stringent starvation protein a Y89_2214 ENOG4107QPN acyl-Coa dehydrogenase Y89_2216 ENOG4108TGY Glutathione S-transferase Y89_2217 ENOG4105DA5 (ABC) transporter Y89_2218 ENOG4105E3A (ABC) transporter Y89_2227 ENOG4106S9K Transcriptional regulator Y89_2231 ENOG4105I93 response regulator Y89_2234 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Y89_2245 ENOG4105VMP Transcriptional regulator Y89_2253 ENOG4105S64 Formate nitrite transporter Y89_2254 ENOG4105CJP fad dependent oxidoreductase Y89_2260 ENOG4105BZU Histidine kinase Y89_2262 ENOG4105JAB phenazine biosynthesis protein, phzf family Y89_2263 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Y89_2265 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y89_2268 ENOG4105EZR dyp-type peroxidase family protein Y89_2275 ENOG4105J5J Outer membrane porin Y89_2285 ENOG4105W39 Membrane Y89_2287 ENOG4107U9T Pfam:Ribonuclease_BN Y89_2293 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Y89_2301 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Y89_2305 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Y89_2311 ENOG4108YGG dna repair protein Y89_2322 ENOG4107QJE Chromosome Partitioning Protein Y89_2327 ENOG4105JQN Transcriptional regulator Y89_2330 ENOG4105CHR reductase Y89_2332 ENOG4105CHR reductase Y89_2333 ENOG4106NZI LysR family Transcriptional regulator Y89_2371 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_2372 ENOG4108Z4U Ferredoxin Y89_2374 ENOG4107YPT transcriptional regulator Y89_2376 ENOG4108HM4 ABC transporter Y89_2378 ENOG4105C6T cysteine synthase Y89_2380 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_2383 ENOG4108ZX5 transcriptional regulator Y89_2387 ENOG4105J5J Outer membrane porin Y89_2392 ENOG4107QS8 (LipO)protein Y89_2395 ENOG4105KPV Transcriptional regulator Y89_2397 ENOG4105NIV Esterase Y89_2398 ENOG4107RNH Outer membrane receptor FepA Y89_2399 ENOG410804D Sensor Signal Transduction Histidine Kinase Y89_2401 ENOG4105CS6 Rhs element vgr protein Y89_2402 ENOG4105CNA YD repeat protein Y89_2406 ENOG4105CC0 LysR family Transcriptional regulator Y89_2407 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Y89_2408 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Y89_2410 ENOG4107QHF type ii secretion system protein e Y89_2411 ENOG4105D7Q type ii secretion system Y89_2412 ENOG4108VAU general secretion pathway protein G Y89_2413 ENOG4108VAU general secretion pathway protein G Y89_2421 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Y89_2423 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Y89_2426 ENOG4105M0Y Y89_2431 ENOG4105XJC Two component transcriptional regulator (Winged helix family Y89_2434 ENOG4105C8Q Methyl-accepting chemotaxis Y89_2435 ENOG4105D3Y Na H antiporter Y89_2436 ENOG4105C8Q Methyl-accepting chemotaxis Y89_2438 ENOG4108I0C methyltransferase Y89_2439 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y89_2440 ENOG4105C8S subunit m Y89_2441 ENOG4105D65 subunit l Y89_2443 ENOG4107UFS subunit j Y89_2446 ENOG4108IEH NADH dehydrogenase subunit g Y89_2447 ENOG4107QIZ NADH dehydrogenase Y89_2448 ENOG4105GKE subunit e Y89_2454 ENOG4107RET Isocitrate lyase Y89_2457 ENOG41082BV acetyltransferase Y89_2458 ENOG4105EZE Cupin 4 family protein Y89_2459 ENOG4107QTF adenylosuccinate lyase Y89_2464 ENOG4105E9K Isocitrate dehydrogenase Y89_2466 ENOG4105VEQ Cold shock protein Y89_2468 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_2469 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Y89_2472 ENOG4105C3M thioredoxin reductase Y89_2473 ENOG4105CNU cell division protein FtsK Y89_2475 ENOG4105D1H recombination factor protein RarA Y89_2477 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y89_2478 ENOG4105CHF Glutathione S-transferase Y89_2479 ENOG4107QYG anthranilate phosphoribosyltransferase Y89_2480 ENOG4108Z0T Part of a sulfur-relay system (By similarity) Y89_2482 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) Y89_2483 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) Y89_2484 ENOG4108MN8 Membrane Y89_2486 ENOG4108T2C cysteine dioxygenase type I Y89_2487 ENOG4105C5Q Transcriptional regulator Y89_2489 ENOG4105GVF (ABC) transporter Y89_2491 ENOG4105FDT acyl-CoA dehydrogenase Y89_2492 ENOG4105GVF (ABC) transporter Y89_2494 ENOG4105GVF (ABC) transporter Y89_2496 ENOG4108HM4 ABC transporter Y89_2497 ENOG4105WH1 Two component transcriptional regulator luxr family Y89_2498 ENOG4105D05 Receptor Y89_2502 ENOG4105WH1 Two component transcriptional regulator luxr family Y89_2505 ENOG4105DFP Integrase Y89_2506 ENOG4105VTW prevent-host-death family Y89_2507 ENOG4105KRQ Addiction module toxin, Txe YoeB family Y89_2513 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Y89_2515 ENOG4105CHU acetyl-coa acetyltransferase Y89_2518 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Y89_2520 ENOG4108VUG Enoyl-CoA hydratase Y89_2521 ENOG4107QX3 carboxylase Y89_2522 ENOG4105C1G acyl-Coa dehydrogenase Y89_2523 ENOG4108Z6Z Transcriptional regulator Y89_2526 ENOG4105D25 secreted protein Y89_2527 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Y89_2532 ENOG4105CPQ Dehydrogenase Y89_2537 ENOG4105C26 Dehydrogenase Y89_2539 ENOG4105D25 secreted protein Y89_2542 ENOG4105DND Transcriptional regulator Y89_2543 ENOG4108V06 Glutathione peroxidase Y89_2544 ENOG4105DTD Dehydrogenase Y89_2546 ENOG4105D25 secreted protein Y89_2547 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity Y89_2550 ENOG4105E39 Enoyl-CoA hydratase Y89_2551 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Y89_2552 ENOG4105C2C drug resistance transporter, Bcr CflA Y89_2553 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Y89_2554 ENOG4108W9H Tetr family transcriptional regulator Y89_2555 ENOG4106A3M Cytochrome p-450 Y89_2557 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Y89_2564 ENOG4108SBK dioxygenase, subunit beta Y89_2566 ENOG4105F9N Major Facilitator Superfamily Y89_2568 ENOG4107Z7P Ferredoxin Y89_2575 ENOG4107SFI Major Facilitator superfamily Y89_2579 ENOG4105K6S Short-chain dehydrogenase reductase Sdr Y89_2580 ENOG4105ERH Fumarylacetoacetate hydrolase Y89_2582 ENOG4106DX9 Aromatic-ring-hydroxylating dioxygenase beta subunit Y89_2584 ENOG4105CHR reductase Y89_2585 ENOG4105CEY Amp-dependent synthetase and ligase Y89_2588 ENOG4105ERH Fumarylacetoacetate hydrolase Y89_2589 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y89_2590 ENOG4105CHU acetyl-coa acetyltransferase Y89_2592 ENOG4106A3M Cytochrome p-450 Y89_2594 ENOG4105D2B acyl-CoA dehydrogenase Y89_2596 ENOG4105E39 Enoyl-CoA hydratase Y89_2597 ENOG4105C1G acyl-Coa dehydrogenase Y89_2601 ENOG4105E1F short-chain dehydrogenase reductase Y89_2604 ENOG4105BZU Histidine kinase Y89_2607 ENOG4105NF4 modulator of drug activity Y89_2608 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) Y89_2609 ENOG4105VDT -acetyltransferase Y89_2613 ENOG4105EEF Alkane 1-monooxygenase Y89_2615 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Y89_2616 ENOG4105BZU Histidine kinase Y89_2617 ENOG4106W3I PA-I galactophilic lectin Y89_2624 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Y89_2625 ENOG4105CHH sulfate transporter Y89_2627 ENOG4108NVR Methyl-accepting chemotaxis Y89_2633 ENOG4105CEY Amp-dependent synthetase and ligase Y89_2634 ENOG4108ZX5 transcriptional regulator Y89_2637 ENOG4105CHU acetyl-coa acetyltransferase Y89_2638 ENOG4105C1G acyl-Coa dehydrogenase Y89_2642 ENOG4105DU1 integral membrane protein, terc Y89_2644 ENOG4105EXG Transcriptional regulator Y89_2645 ENOG4108UYE Lactoylglutathione lyase Y89_2646 ENOG4105CGK Exodeoxyribonuclease III Y89_2648 ENOG4105CFU surface antigen Y89_2650 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase Y89_2651 ENOG4105E8V Alpha Beta Hydrolase Fold protein Y89_2652 ENOG41077RS Phosphatase Y89_2655 ENOG4108HPI phosphatidate Cytidylyltransferase Y89_2656 ENOG4105CPC Aldo Keto reductase Y89_2658 ENOG4105BZG amino acid carrier protein Y89_2659 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Y89_2660 ENOG4105CIH Imidazole acetol-phosphate transaminase Y89_2664 ENOG4105BZS acriflavin resistance protein Y89_2665 ENOG4105BZS acriflavin resistance protein Y89_2666 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_2678 ENOG4105F57 Anthranilate dioxygenase reductase Y89_2679 ENOG4108YS2 small subunit Y89_2680 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit Y89_2682 ENOG4108KB2 LysR family Transcriptional regulator Y89_2683 ENOG4105DTQ mandelate racemase muconate lactonizing Y89_2684 ENOG4105NN7 muconolactone delta-isomerase Y89_2685 ENOG410626B catechol 1,2-dioxygenase Y89_2687 ENOG4105J5J Outer membrane porin Y89_2692 ENOG4105DJ2 Major Facilitator Superfamily Y89_2693 ENOG4107Y2X deaminase Y89_2695 ENOG4105JQN Transcriptional regulator Y89_2700 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression Y89_2718 ENOG4105DEN Luciferase family Y89_2719 ENOG41090Y2 cytochrome C Y89_2720 ENOG4105NQN cytochrome C Y89_2721 ENOG4105DHQ Histidine kinase Y89_2722 ENOG4105XJC Two component transcriptional regulator (Winged helix family Y89_2723 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Y89_2725 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase Y89_2728 ENOG4108RXX maleylacetoacetate isomerase Y89_2729 ENOG4105D2S major facilitator superfamily Y89_2732 ENOG4107R11 Transcriptional regulator Y89_2733 ENOG4108SF5 RNA Polymerase Y89_2734 ENOG4108S3W Anti-feci sigma factor, fecr Y89_2738 ENOG4105D5K Hemolysin activator protein Y89_2739 ENOG4105CKT filamentous hemagglutinin Y89_2745 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Y89_2747 ENOG4105E93 esterase Y89_2751 ENOG4105EJC lysr family transcriptional regulator Y89_2752 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Y89_2753 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Y89_2754 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Y89_2755 ENOG4105EJQ L-serine dehydratase Y89_2756 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Y89_2766 ENOG4108NUU Transcriptional regulator Y89_2767 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) Y89_2769 ENOG4105Y49 secretion protein, HlyD family Y89_2771 ENOG4105CSR polyphosphate kinase 2 Y89_2779 ENOG4105J5J Outer membrane porin Y89_2780 ENOG4105CHJ isochorismatase hydrolase Y89_2781 ENOG4105CHJ isochorismatase hydrolase Y89_2782 ENOG4105EUB pirin domain protein Y89_2783 ENOG4105HEI LysR family (Transcriptional regulator Y89_2784 ENOG4105E53 ec 3.2.1.28 Y89_2792 ENOG4105FDK ABC transporter Y89_2802 ENOG4105IBP Cyclic peptide transporter Y89_2808 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_2810 ENOG4105DJY efflux transporter, rnd family, mfp subunit Y89_2813 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) Y89_2814 ENOG4107SQI penicillin amidase Y89_2815 ENOG41090R7 Ferric uptake Y89_2816 ENOG4108MGI Transcriptional regulator Y89_2817 ENOG4105DMF Dehydrogenase Y89_2823 ENOG4108ZXC Two component transcriptional regulator, luxr family Y89_2826 ENOG4105CS6 Rhs element vgr protein Y89_2829 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_2843 ENOG4108UZX fmn reductase Y89_2844 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Y89_2845 ENOG4107T8P acyl-Coa dehydrogenase Y89_2846 ENOG4107SM7 Transcriptional regulator Y89_2847 ENOG4105D6Z AFG1 family ATPase Y89_2848 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Y89_2849 ENOG4108UMI ABC transporter, permease Y89_2850 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Y89_2851 ENOG4105D01 (LipO)protein Y89_2853 ENOG4107T8P acyl-Coa dehydrogenase Y89_2878 ENOG4107SC1 transglycosylase Y89_2884 ENOG4105CF2 Mu-like prophage FluMu protein GP28 Y89_2886 ENOG4108QUU Morphogenesis Protein Y89_2910 ENOG4107Y7Q pfkb domain protein Y89_2911 ENOG4105CMG Carbohydrate kinase Y89_2912 ENOG4105DEI Mannitol dehydrogenase Y89_2913 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y89_2915 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Y89_2919 ENOG4107ZSV Receptor Y89_2922 ENOG4105E7U AraC family transcriptional regulator Y89_2925 ENOG4105D7T ABC transporter Y89_2926 ENOG4105I5W Transporter Y89_2927 ENOG4105DG7 nitrate ABC transporter Y89_2929 ENOG4107T8P acyl-Coa dehydrogenase Y89_2931 ENOG4105C26 Dehydrogenase Y89_2933 ENOG4105C6Z Gluconate Y89_2934 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Y89_2935 ENOG4105DIQ Transcriptional regulator Y89_2937 ENOG4105CJP fad dependent oxidoreductase Y89_2938 ENOG4105HEI LysR family (Transcriptional regulator Y89_2939 ENOG4107S1E Beta-lactamase Y89_2942 ENOG4108JCI Transcriptional regulator Y89_2944 ENOG4105E2B Taurine dioxygenase Y89_2947 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Y89_2952 ENOG4105CEY Amp-dependent synthetase and ligase Y89_2952 ENOG4105CEY Amp-dependent synthetase and ligase Y89_2954 ENOG4105E03 chitinase Y89_2955 ENOG4108X79 transcriptional regulator Y89_2956 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Y89_2959 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Y89_2963 ENOG4105TW1 Carbohydrate-selective porin OprB Y89_2964 ENOG4105DZG Dehydrogenase Y89_2965 ENOG4105CHB tonB-dependent Receptor Y89_2974 ENOG4105CAU Arsenical resistance protein, ArsH Y89_2975 ENOG4107WAU Protein tyrosine phosphatase Y89_2977 ENOG41082YX Transcriptional regulator, arsr family Y89_2978 ENOG4105CF7 AraC family transcriptional regulator Y89_2979 ENOG4105DQ4 alcohol dehydrogenase Y89_2981 ENOG4108Z4X TRANSCRIPTIONal Y89_2982 ENOG4105CJN penicillin-binding protein Y89_2983 ENOG4105XYF acetyltransferase Y89_2986 ENOG4105KAC Antibiotic biosynthesis monooxygenase Y89_2993 ENOG4105D7K pfkb domain protein Y89_2995 ENOG4108M60 Transcriptional regulator Y89_2996 ENOG4105JQN Transcriptional regulator Y89_2998 ENOG4105EFA 4-hydroxyphenylacetate Y89_3001 ENOG4105HDK L-asparaginase Y89_3004 ENOG4107QN2 dihydrolipoyl dehydrogenase Y89_3005 ENOG4107QSN dihydrolipoamide acetyltransferase Y89_3006 ENOG4105CPP Dehydrogenase, E1 component Y89_3007 ENOG4107R0V Pyruvate dehydrogenase Y89_3009 ENOG4105J0Q Transcriptional regulator Y89_3012 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Y89_3014 ENOG4105CJR Integral membrane protein (MviN Y89_3021 ENOG4105DAY polysaccharide export protein Y89_3022 ENOG4108KBE Glycosyl transferase, family 2 Y89_3024 ENOG4105D3Q Sugar transferase Y89_3026 ENOG4108RPX mosc domain containing protein Y89_3033 ENOG4105G9B Transcriptional regulator Y89_3035 ENOG4107SP2 The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity Y89_3036 ENOG4107R13 MMPL domain protein Y89_3040 ENOG4105CJP fad dependent oxidoreductase Y89_3043 ENOG4105CT3 Monooxygenase Y89_3046 ENOG4105CUB amino acid Y89_3047 ENOG4105C26 Dehydrogenase Y89_3048 ENOG4108JPW Aminotransferase Y89_3051 ENOG4107QN1 sodium solute Y89_3052 ENOG41062QD Membrane Y89_3053 ENOG4105CEY Amp-dependent synthetase and ligase Y89_3054 ENOG4105CHR reductase Y89_3055 ENOG4105C1G acyl-Coa dehydrogenase Y89_3058 ENOG4108JU7 Transcriptional regulator Y89_3060 ENOG4105DY2 Paraquat-inducible protein b Y89_3061 ENOG4105F1S paraquat-inducible protein a Y89_3062 ENOG4105CZJ Aldehyde dehydrogenase Y89_3064 ENOG4105CXK mandelate racemase muconate lactonizing Y89_3065 ENOG4105CSP Major Facilitator Superfamily Y89_3066 ENOG4105EPF Outer membrane porin Y89_3067 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Y89_3069 ENOG4105DJB Major Facilitator Superfamily Y89_3077 ENOG4105DRP amino acid AbC transporter Y89_3079 ENOG4105BZU Histidine kinase Y89_3080 ENOG4106KE4 Dehydrogenase Y89_3082 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Y89_3083 ENOG4108WUH Transcriptional regulator, TetR family Y89_3084 ENOG4105MWK D-amino acid dehydrogenase, small subunit Y89_3085 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein Y89_3086 ENOG41065RR hydrogen cyanide synthase HcnA Y89_3087 ENOG41080XP Cbs domain Y89_3094 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Y89_3097 ENOG4105BZU Histidine kinase Y89_3103 ENOG4105CN9 Peptidase m42 family protein Y89_3111 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Y89_3112 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Y89_3120 ENOG4105X23 Endonuclease Exonuclease phosphatase Y89_3121 ENOG4105DZQ phospholipase D Transphosphatidylase Y89_3122 ENOG4107UXM Membrane Y89_3123 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Y89_3124 ENOG4105CG3 alpha amylase, catalytic region Y89_3125 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) Y89_3126 ENOG4105FDF Could be involved in DNA repair (By similarity) Y89_3128 ENOG4105KT7 mgtC SapB transporter Y89_3130 ENOG4105CH6 catalase Y89_3134 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Y89_3138 ENOG4108WTK competence damage-inducible protein Y89_3141 ENOG4105DQE DNA ligase Y89_3148 ENOG4105GQR Chaperone Y89_3150 ENOG4105CW0 outer membrane usher protein Y89_3151 ENOG4105GQR Chaperone Y89_3153 ENOG4105BZV Phosphoadenosine phosphosulfate reductase Y89_3154 ENOG4105GTN ParB Domain Protein Nuclease Y89_3155 ENOG4105C26 Dehydrogenase Y89_3156 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Y89_3157 ENOG4105CC0 LysR family Transcriptional regulator Y89_3161 ENOG4105CPQ Dehydrogenase Y89_3163 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Y89_3167 ENOG4107RGD Major Facilitator superfamily Y89_3171 ENOG4107R7A Allophanate hydrolase subunit 2 Y89_3177 ENOG4107RN6 Monooxygenase Y89_3181 ENOG4105K6V RNA polymerase Y89_3182 ENOG4105F27 Major Facilitator Y89_3184 ENOG4105FBW Monooxygenase Y89_3185 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Y89_3188 ENOG4105EBM Alpha Beta Hydrolase Fold protein Y89_3189 ENOG4106DX9 Aromatic-ring-hydroxylating dioxygenase beta subunit Y89_3190 ENOG4105CAQ asparagine synthetase Y89_3191 ENOG4105FUY alpha subunit Y89_3192 ENOG4105F7P transcriptional regulator AsnC family Y89_3195 ENOG4105C85 amino acid Y89_3201 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Y89_3202 ENOG4105ETS cytosine purines uracil thiamine allantoin Y89_3204 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Y89_3207 ENOG4105D8G Major Facilitator superfamily Y89_3213 ENOG4105C3J Cysteine desulfurase Y89_3214 ENOG4108JQ5 ABC transporter Y89_3215 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component Y89_3216 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component Y89_3218 ENOG4105D05 Receptor Y89_3219 ENOG4105EQ2 LysR family Transcriptional regulator Y89_3221 ENOG4105DND Transcriptional regulator Y89_3222 ENOG4107B2H carbonic anhydrase Y89_3225 ENOG4108SF5 RNA Polymerase Y89_3244 ENOG4105EFV Major head subunit Y89_3249 ENOG4105QIB mu-like prophage Flumu protein gp29 Y89_3250 ENOG4105CF2 Mu-like prophage FluMu protein GP28 Y89_3255 ENOG4107SC1 transglycosylase Y89_3276 ENOG4105CF7 AraC family transcriptional regulator Y89_3280 ENOG4105D3G Pseudouridine synthase Y89_3281 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Y89_3282 ENOG4105CUB amino acid Y89_3283 ENOG4105CFQ glutamine synthetase Y89_3287 ENOG4105C7K acetolactate synthase Y89_3290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y89_3294 ENOG4108XM1 transcriptional regulator AsnC family Y89_3296 ENOG4105DHU Bile acid Y89_3297 ENOG4105DC8 reductase Y89_3298 ENOG4105HUJ glyoxalase bleomycin resistance protein dioxygenase Y89_3299 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Y89_3300 ENOG4105C6Y Udp-glucose 6-dehydrogenase Y89_3302 ENOG4108IG5 Transcriptional regulator Y89_3303 ENOG4105C1P efflux transporter, rnd family, mfp subunit Y89_3304 ENOG4105BZS acriflavin resistance protein Y89_3306 ENOG4108ZK4 sdia-regulated domain-containing protein Y89_3307 ENOG4108Z6Z Transcriptional regulator Y89_3308 ENOG4105C1G acyl-Coa dehydrogenase Y89_3309 ENOG4107QX3 carboxylase Y89_3312 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Y89_3315 ENOG4105ERH Fumarylacetoacetate hydrolase Y89_3316 ENOG4108RXX maleylacetoacetate isomerase Y89_3317 ENOG4105D2S major facilitator superfamily Y89_3318 ENOG4108JUB Transcriptional regulator Y89_3319 ENOG4105CY2 Citrate transporter Y89_3320 ENOG4105DTD Dehydrogenase Y89_3321 ENOG4105CRW Short chain fatty acid transporter Y89_3322 ENOG4105CHU acetyl-coa acetyltransferase Y89_3324 ENOG4105D6N CoA-transferase, subunit a Y89_3325 ENOG4105DND Transcriptional regulator Y89_3326 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Y89_3327 ENOG4105KQ5 peptidylprolyl cis-trans isomerase Y89_3330 ENOG4105F9N Major Facilitator Superfamily Y89_3331 ENOG4105I8F Histidine kinase Y89_3339 ENOG4105C26 Dehydrogenase Y89_3340 ENOG4105DZG Dehydrogenase Y89_3341 ENOG4105DZG Dehydrogenase Y89_3346 ENOG4108W5X Transcriptional Regulator, LuxR family Y89_3348 ENOG4105BZU Histidine kinase Y89_3351 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF Y89_3352 ENOG4105DIJ Phosphoethanolamine transferase Y89_3353 ENOG4105CWM branched-chain amino acid transport system II carrier protein Y89_3360 ENOG4105C5H ABC transporter Y89_3362 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Y89_3363 ENOG4105CC0 LysR family Transcriptional regulator Y89_3365 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Y89_3374 ENOG4108RVA ribokinase Y89_3375 ENOG4105ETE Transcriptional regulator (LacI family Y89_3376 ENOG4105CNN ABC, transporter Y89_3377 ENOG4105C2J ABC transporter Y89_3378 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Y89_3388 ENOG4105C7W Xanthine dehydrogenase Y89_3389 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding Y89_3390 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit Y89_3391 ENOG4107SDU Methyl-accepting chemotaxis Y89_3393 ENOG4105D9U N-acetyltransferase Y89_3395 ENOG4105DDY UPF0142 protein ycaO Y89_3399 ENOG4105D05 Receptor Y89_3401 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Y89_3404 ENOG4105D5U fad dependent oxidoreductase Y89_3411 ENOG4108SF5 RNA Polymerase Y89_3412 ENOG4108S3W Anti-feci sigma factor, fecr Y89_3414 ENOG4108VN5 Inherit from COG: PepSY-associated TM helix Y89_3416 ENOG4107RDB Major Facilitator Y89_3420 ENOG4105JAB phenazine biosynthesis protein, phzf family Y89_3426 ENOG4105VJY transcriptional regulator Y89_3431 ENOG4105CUJ penicillin amidase Y89_3434 ENOG4108TGY Glutathione S-transferase Y89_3439 ENOG4105CQ2 DNA polymerase Y89_3442 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Y89_3454 ENOG4108VC8 Peptidase family M23 Y89_3457 ENOG4105GVR general secretion pathway protein D Y89_3461 ENOG4105F2V VRR-NUC domain-containing protein Y89_3462 ENOG4108IG5 Transcriptional regulator Y89_3463 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Y89_3464 ENOG4105E0C molybdate abc transporter Y89_3465 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Y89_3467 ENOG4105HEI LysR family (Transcriptional regulator Y89_3470 ENOG4105CKW Inner membrane protein yedI Y89_3471 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Y89_3473 ENOG4105CJW magnesium transporter Y89_3478 ENOG4105XDF Protein of unknown function (DUF1272) Y89_3484 ENOG4105C3R Methionine synthase Y89_3488 ENOG4105EVD ribosomal RNA large subunit methyltransferase N Y89_3491 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Y89_3497 ENOG4105ERU peptidase Y89_3501 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Y89_3502 ENOG4105CHR reductase Y89_3503 ENOG4108KB2 LysR family Transcriptional regulator Y89_3506 ENOG4105E09 nadh pyrophosphatase Y89_3508 ENOG4105E39 Enoyl-CoA hydratase Y89_3510 ENOG4105D5Q Arginine ornithine antiporter Y89_3511 ENOG4105CXN decarboxylase Y89_3513 ENOG4107RZZ dna polymerase iii epsilon subunit Y89_3516 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Y89_3517 ENOG4105E9H Lytic Murein transglycosylase Y89_3518 ENOG4105E43 Extracellular solute-binding protein, family 5 Y89_3519 ENOG4105E43 Extracellular solute-binding protein, family 5 Y89_3520 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component Y89_3521 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component Y89_3522 ENOG4108JQ5 ABC transporter Y89_3523 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Y89_3524 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Y89_3525 ENOG4105K70 DNA-binding protein Y89_3526 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Y89_3528 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Y89_3530 ENOG4107EXC regulatoR Y89_3531 ENOG4105JJR Histidine kinase Y89_3532 ENOG4108A04 Beta-lactamase Y89_3538 ENOG4105CX6 glutaminyL-tRNA synthetase Y89_3539 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Y89_3542 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase Y89_3543 ENOG4105Q9Y Universal stress protein Y89_3545 ENOG4107QIJ Aconitate hydratase 2 Y89_3547 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Y89_3551 ENOG4108IFG nitrite reductase, (NAD(P)H) Y89_3552 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit Y89_3554 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y89_3555 ENOG4105CDV Ompa motb domain protein Y89_3564 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Y89_3572 ENOG41061ZR Transcriptional regulator Y89_3573 ENOG41061ZR Transcriptional regulator Y89_3574 ENOG4105CRQ synthase (Component I) Y89_3575 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein Y89_3578 ENOG4107R11 Transcriptional regulator Y89_3580 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Y89_3582 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Y89_3590 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Y89_3593 ENOG4105CPC Aldo Keto reductase Y89_3594 ENOG4105EQ2 LysR family Transcriptional regulator Y89_3595 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y89_3596 ENOG4105CHU acetyl-coa acetyltransferase Y89_3604 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Y89_3606 ENOG4105BZU Histidine kinase Y89_3607 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Y89_3613 ENOG41070MY type iii secretion Y89_3614 ENOG41066XE Type III export protein Y89_3620 ENOG4108KB1 transcriptional regulator, arac family Y89_3623 ENOG4106V6P Exoenzyme S synthesis protein C Y89_3646 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Y89_3651 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) Y89_3656 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) Y89_3660 ENOG4105EUJ GTP cyclohydrolase i Y89_3671 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_3672 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_3680 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y89_3683 ENOG4105DKK Benzoate Y89_3686 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Y89_3688 ENOG4108NVR Methyl-accepting chemotaxis Y89_3690 ENOG4105EW6 flavin reductase domain protein, FMN-binding Y89_3693 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) Y89_3698 ENOG4105EEX Two component transcriptional regulator (Winged helix family Y89_3699 ENOG4105C08 Histidine kinase Y89_3701 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Y89_3702 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Y89_3704 ENOG4105C1G acyl-Coa dehydrogenase Y89_3706 ENOG4105E39 Enoyl-CoA hydratase Y89_3707 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y89_3708 ENOG41073TP transcriptional regulator Y89_3709 ENOG4105DJ2 Major Facilitator Superfamily Y89_3710 ENOG4105IPI Membrane Y89_3712 ENOG4105CYM Glutathione S-transferase Y89_3716 ENOG41063TF transcriptional regulator (AraC Y89_3717 ENOG4105KA0 thioesterase Superfamily protein Y89_3718 ENOG4108IQE Amp-dependent synthetase and ligase Y89_3722 ENOG4107RNH Outer membrane receptor FepA Y89_3724 ENOG4105BZU Histidine kinase Y89_3732 ENOG4108VHT MarR family transcriptional regulator Y89_3733 ENOG4108XHQ (2Fe-2S)-binding domain protein Y89_3734 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Y89_3735 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Y89_3736 ENOG4105R1U AraC Family Transcriptional Regulator Y89_3739 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Y89_3745 ENOG4105CWM branched-chain amino acid transport system II carrier protein Y89_3746 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Y89_3748 ENOG4107QN2 dihydrolipoyl dehydrogenase Y89_3749 ENOG4105C7S Dehydrogenase Y89_3750 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Y89_3751 ENOG4105E33 succinate dehydrogenase Y89_3752 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Y89_3753 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein Y89_3754 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit Y89_3755 ENOG4105BZN citrate synthase Y89_3756 ENOG4105VV6 START domain-containing protein Y89_3760 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Y89_3763 ENOG4108XC3 NADH ubiquinone oxidoreductase Y89_3766 ENOG4105DUM transcriptional regulator, lysR family Y89_3768 ENOG4105M4H endoribonuclease L-psp Y89_3769 ENOG4105CJP fad dependent oxidoreductase Y89_3770 ENOG4105CFQ glutamine synthetase Y89_3771 ENOG4105CJP fad dependent oxidoreductase Y89_3774 ENOG4107QM5 aconitate hydratase Y89_3776 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Y89_3779 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Y89_3782 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) Y89_3783 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i Y89_3786 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) Y89_3787 ENOG4105C58 cytochrome c oxidase accessory protein ccog Y89_3789 ENOG4105C59 p-type ATPase Y89_3792 ENOG4105D4P Coproporphyrinogen iii oxidase Y89_3794 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Y89_3797 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) Y89_3799 ENOG4105EJ2 Transcriptional regulator Y89_3800 ENOG4107RN6 Monooxygenase Y89_3802 ENOG4106611 bacteriocin immunity Y89_3803 ENOG4105C1G acyl-Coa dehydrogenase Y89_3805 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Y89_3806 ENOG4107QMP dna polymerase iii subunits gamma and tau Y89_3811 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Y89_3813 ENOG4105EEF Alkane 1-monooxygenase Y89_3817 ENOG4107QUY Guanine deaminase Y89_3819 ENOG4105C7N Xanthine uracil vitamin C permease Y89_3820 ENOG4105VT2 5-hydroxyisourate hydrolase Y89_3826 ENOG4108WC9 type VI secretion system effector, hcp1 family Y89_3827 ENOG4105CS6 Rhs element vgr protein Y89_3831 ENOG4105C2W permease Y89_3833 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Y89_3834 ENOG4108R86 Transcriptional regulator Y89_3836 ENOG41060W2 glyoxylate carboligase Y89_3837 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Y89_3838 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Y89_3840 ENOG4105CA9 Pyruvate kinase Y89_3842 ENOG4105EYW Ion transport protein Y89_3845 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Y89_3847 ENOG4105ENY Ethanolamine utilization protein eutH Y89_3848 ENOG4105E98 transcriptional regulator DeoR family Y89_3849 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein Y89_3851 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Y89_3854 ENOG4105WH1 Two component transcriptional regulator luxr family Y89_3856 ENOG4108M1T Cytochrome c-type biogenesis protein Y89_3857 ENOG4105KWW Biogenesis protein Y89_3858 ENOG4107QX9 Thiol disulfide interChange protein Y89_3859 ENOG4105DA4 cytochrome c-type biogenesis protein Y89_3861 ENOG41067VX Heme exporter protein Y89_3862 ENOG41060IM Heme exporter protein Y89_3863 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) Y89_3864 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) Y89_3867 ENOG4105KNA -acetyltransferase Y89_3870 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Y89_3875 ENOG4108V3W Chemotaxis protein, CheW Y89_3877 ENOG4107QJE Chromosome Partitioning Protein Y89_3878 ENOG4105ER2 Ompa motb domain protein Y89_3879 ENOG4105E14 MotA TolQ exbB proton channel Y89_3880 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Y89_3881 ENOG4105CBS Chea signal transduction histidine kinase Y89_3883 ENOG4108VYJ response regulator receiver protein Y89_3884 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y89_3886 ENOG4105FZW flagellar biosynthesis regulator FlhF Y89_3887 ENOG4105D7B Flagellar biosynthesis protein flha Y89_3888 ENOG4105HA9 of methanol dehydrogenase type Y89_3890 ENOG4105D00 flagellar biosynthetic protein flhB Y89_3891 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Y89_3892 ENOG4105VS8 Flagellar biosynthetic protein fliq Y89_3893 ENOG4105CN7 Flagellar biosynthetic protein FliP Y89_3894 ENOG4105VTB flagellar biosynthesis protein fliO Y89_3895 ENOG4105DD5 Flagellar motor switch protein Y89_3896 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Y89_3900 ENOG4105WD1 Membrane Y89_3903 ENOG4105BZS acriflavin resistance protein Y89_3906 ENOG4105BZU Histidine kinase Y89_3907 ENOG4105NNS Autoinducer synthesis protein Y89_3909 ENOG4105VJY transcriptional regulator Y89_3911 ENOG4105K5X acetyltransferase Y89_3913 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) Y89_3916 ENOG4105K9H YciI-like protein Y89_3919 ENOG4105C26 Dehydrogenase Y89_3922 ENOG4105CBN LysR family transcriptional regulator Y89_3926 ENOG4107SDU Methyl-accepting chemotaxis Y89_3927 ENOG4105EVZ LysR family transcriptional regulator Y89_3928 ENOG4105CYW agmatinase Y89_3932 ENOG4105C7K acetolactate synthase Y89_3934 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Y89_3936 ENOG4105EGI Transcriptional regulator Y89_3938 ENOG4105FR1 rard protein Y89_3939 ENOG4107RUE extracellular solute-binding protein family 1 Y89_3940 ENOG41067B5 Histone deacetylase superfamily protein Y89_3941 ENOG4105EGS Mechanosensitive ion channel Y89_3942 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Y89_3944 ENOG41088T4 Helicase IV Y89_3946 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Y89_3949 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Y89_3953 ENOG4105BZU Histidine kinase Y89_3956 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) Y89_3958 ENOG4105CG5 Glycosyl transferase (Group 1 Y89_3960 ENOG4107TAE Glycosyl transferase (Group 1 Y89_3963 ENOG4105EY8 ABC transporter Y89_3965 ENOG4105CMR udp-glucose 4-epimerase Y89_3967 ENOG4105GVR general secretion pathway protein D Y89_3969 ENOG4105CF7 AraC family transcriptional regulator Y89_3970 ENOG4105EMU Dehydrogenase Y89_3972 ENOG4105WCN acetyltransferase Y89_3973 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) Y89_3979 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) Y89_3980 ENOG4107YPT transcriptional regulator Y89_3981 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y89_3988 ENOG4107QI1 Mate efflux family protein Y89_3989 ENOG4107AQZ Membrane Y89_3992 ENOG4108UIN ybak prolyl-trna synthetase associated region Y89_3995 ENOG4105GRZ Ycii-related protein Y89_3997 ENOG4105EQ0 Major Facilitator superfamily Y89_3998 ENOG4105CHP RNA polymerase Y89_4001 ENOG4105GRZ Ycii-related protein Y89_4003 ENOG4108Q9V regulatoR Y89_4004 ENOG4105CXN decarboxylase Y89_4005 ENOG4105D7Z glutathione synthase Y89_4006 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Y89_4008 ENOG4107RP9 extracellular solute-binding protein, family 3 Y89_4009 ENOG4105EAD ABC transporter Y89_4010 ENOG4105DRP amino acid AbC transporter Y89_4011 ENOG4105CDA abc transporter atp-binding protein Y89_4012 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Y89_4013 ENOG4105HDK L-asparaginase Y89_4014 ENOG4105CQZ Histidine kinase Y89_4015 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_4016 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_4019 ENOG4105EE5 Membrane protein terC Y89_4020 ENOG4105E1F short-chain dehydrogenase reductase Y89_4022 ENOG410642W LysR family Transcriptional regulator Y89_4024 ENOG4105C7B Threonine dehydratase Y89_4025 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein Y89_4028 ENOG4108ESX Receptor Y89_4030 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Y89_4031 ENOG4105CCU oxidase (Subunit III) Y89_4032 ENOG4105BZ9 Cytochrome C oxidase, subunit I Y89_4033 ENOG4105E2S oxidase) subunit II Y89_4037 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y89_4038 ENOG4105JQN Transcriptional regulator Y89_4041 ENOG4105DUM transcriptional regulator, lysR family Y89_4043 ENOG4105E7A Glutamine amidotransferase Y89_4047 ENOG4105C3F Signal peptidase i Y89_4049 ENOG4108S3W Anti-feci sigma factor, fecr Y89_4050 ENOG410904A RNA polymerase Y89_4051 ENOG4108ZZ3 UPF0260 protein Y89_4053 ENOG4105PGM cation diffusion facilitator family transporter Y89_4054 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Y89_4058 ENOG4105KHC sulfurtransferase Y89_4062 ENOG4105ISI outer membrane protein, OMPP1 FadL TodX family Y89_4066 ENOG4105CSU acyl-Coa dehydrogenase Y89_4070 ENOG4108TGR phosphatase Y89_4071 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Y89_4072 ENOG4108YZT Adenosylcobinamide kinase Y89_4073 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Y89_4074 ENOG4105EFT decarboxylase Y89_4075 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Y89_4076 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Y89_4077 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Y89_4078 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Y89_4079 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Y89_4081 ENOG4105G3Z GntR family transcriptional regulator Y89_4082 ENOG4105CTU Proline racemase Y89_4093 ENOG4105DRP amino acid AbC transporter Y89_4095 ENOG4105CDA abc transporter atp-binding protein Y89_4096 ENOG4105CTU Proline racemase Y89_4097 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Y89_4098 ENOG4105CZJ Aldehyde dehydrogenase Y89_4099 ENOG4105DG4 malate L-lactate dehydrogenase Y89_4101 ENOG41065N1 inhibitor Y89_4102 ENOG4105QNJ serralysin (EC 3.4.24.40) Y89_4103 ENOG4105DFG type I secretion outer membrane protein Y89_4104 ENOG4107QZV Type I secretion membrane fusion protein Y89_4105 ENOG4108JJ6 Type I secretion system ATPase Y89_4108 ENOG4105CQZ Histidine kinase Y89_4115 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_4116 ENOG4105CW7 secretion protein, HlyD family Y89_4121 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) Y89_4124 ENOG4105R1U AraC Family Transcriptional Regulator Y89_4128 ENOG4105DYS nad(p)h dehydrogenase (quinone) Y89_4129 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF Y89_4131 ENOG4105CA3 membrane-bound lytic murein transglycosylase Y89_4136 ENOG4107SDT Homocitrate synthase Y89_4138 ENOG4105CEY Amp-dependent synthetase and ligase Y89_4139 ENOG4105CAQ asparagine synthetase Y89_4141 ENOG4105E5W Transporter Y89_4143 ENOG4105C2I pirin domain protein Y89_4146 ENOG4105CKD glutathione-regulated potassium-efflux system protein Y89_4148 ENOG4105EUB pirin domain protein Y89_4149 ENOG4108YYH Nadph-dependent fmn reductase Y89_4151 ENOG4105CHJ isochorismatase hydrolase Y89_4152 ENOG4105CC0 LysR family Transcriptional regulator Y89_4154 ENOG4105K4H Nlp p60 protein Y89_4155 ENOG4108QBX (LipO)protein Y89_4156 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Y89_4157 ENOG4108JUB Transcriptional regulator Y89_4158 ENOG4106V2I dimethylaminohydrolase Y89_4159 ENOG4105D5Q Arginine ornithine antiporter Y89_4160 ENOG4108R3E Dna-3-methyladenine glycosylase i Y89_4163 ENOG41069YE inner membrane protein yohC Y89_4165 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Y89_4166 ENOG4105C1G acyl-Coa dehydrogenase Y89_4168 ENOG4105CYM Glutathione S-transferase Y89_4169 ENOG4105ETT transcriptional Regulator, LysR family Y89_4172 ENOG4105BZU Histidine kinase Y89_4174 ENOG4105XJC Two component transcriptional regulator (Winged helix family Y89_4177 ENOG4108ZNS ferredoxin-type protein NapF Y89_4178 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase Y89_4182 ENOG4105CVE Lytic murein transglycosylase Y89_4183 ENOG4108ZCF integral membrane protein Y89_4184 ENOG4107EFQ arachidonate 15-lipoxygenase Y89_4188 ENOG4108TSE Transferase Y89_4189 ENOG4105CUZ uba thif-type nad fad binding protein Y89_4192 ENOG4105DHI Methyltransferase Y89_4194 ENOG4105VEQ Cold shock protein Y89_4195 ENOG4105JJR Histidine kinase Y89_4196 ENOG4107EXC regulatoR Y89_4197 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Y89_4198 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Y89_4199 ENOG4108UK5 Transposase Y89_4201 ENOG41060S4 immunity protein Y89_4205 ENOG4105CUB amino acid Y89_4206 ENOG4105C0A alcohol dehydrogenase Y89_4207 ENOG4105EVZ LysR family transcriptional regulator Y89_4209 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Y89_4211 ENOG4105EGI Transcriptional regulator Y89_4212 ENOG4105S0E allantoin catabolism protein Y89_4216 ENOG4107WYG Transcriptional regulator, luxr family Y89_4223 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) Y89_4224 ENOG410642W LysR family Transcriptional regulator Y89_4225 ENOG4108FN7 Aldo keto reductase Y89_4227 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Y89_4228 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Y89_4230 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Y89_4231 ENOG4108WS1 Y89_4232 ENOG4108KHX Diguanylate cyclase Y89_4233 ENOG41090EK ompa motb domain protein Y89_4239 ENOG4105BZ1 (ABC) transporter Y89_4241 ENOG4105VYA Uncharacterized conserved protein (DUF2132) Y89_4242 ENOG4105D8V Glucose sorbosone dehydrogenase Y89_4245 ENOG4105R1U AraC Family Transcriptional Regulator Y89_4246 ENOG41079KZ Major Facilitator Superfamily Y89_4249 ENOG4105GSA Flagellar export protein flij Y89_4250 ENOG4108JIR Flagellum-specific ATP synthase Y89_4252 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Y89_4253 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Y89_4255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_4256 ENOG4105BZU Histidine kinase Y89_4257 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_4259 ENOG4105MQ3 flagellar protein FliS Y89_4260 ENOG4105DTS flagellar hook-associated Y89_4261 ENOG41063QE flagellar protein FlaG Y89_4262 ENOG4105I03 Flagellin Y89_4263 ENOG4107RGC Glycosyl transferase, family 2 Y89_4264 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Y89_4267 ENOG4105DTJ flagellar hook-associated protein Y89_4268 ENOG4105E1Q flagellar hook-associated protein Y89_4269 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Y89_4272 ENOG4105CGA flagellar basal-body rod protein FlgG Y89_4273 ENOG4108KPB Flagellar basal-body rod protein FlgF Y89_4274 ENOG4105BZE flagellar hook protein, FlgE Y89_4275 ENOG4105W00 Flagellar hook capping protein Y89_4276 ENOG4108ZC9 flagellar basal-body rod protein flgc Y89_4277 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Y89_4280 ENOG4105CP9 extracellular ligand-binding receptor Y89_4281 ENOG4105C32 Amino acid ABC transporter (Permease) Y89_4282 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Y89_4283 ENOG4105C0Z ABC transporter Y89_4284 ENOG4108IV0 ABC, transporter Y89_4286 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Y89_4287 ENOG4105JQN Transcriptional regulator Y89_4289 ENOG4105K78 MarR family Transcriptional regulator Y89_4293 ENOG4105C6T cysteine synthase Y89_4296 ENOG4105W4C monovalent cation H antiporter subunit F Y89_4297 ENOG4105SC1 monovalent cation H antiporter subunit E Y89_4298 ENOG4107R4Z monovalent cation h antiporter subunit d Y89_4299 ENOG4108ZE9 Monovalent cation H antiporter subunit C Y89_4300 ENOG4105D65 subunit l Y89_4301 ENOG4108XTF Outer Membrane Lipoprotein Y89_4303 ENOG4105BZW Glycerate kinase Y89_4304 ENOG4105C6Z Gluconate Y89_4305 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR Y89_4306 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Y89_4307 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 Y89_4310 ENOG4105DVT helicase Y89_4314 ENOG4105CDV Ompa motb domain protein Y89_4316 ENOG4105K5B UPF0225 protein Y89_4318 ENOG4105EN6 Membrane Y89_4322 ENOG4105CYM Glutathione S-transferase Y89_4323 ENOG4105CUJ penicillin amidase Y89_4324 ENOG4105CGY Dna recombination protein Y89_4327 ENOG4105CJP fad dependent oxidoreductase Y89_4328 ENOG4105C26 Dehydrogenase Y89_4330 ENOG4105EPF Outer membrane porin Y89_4331 ENOG4105EA8 2-Nitropropane dioxygenase Y89_4332 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Y89_4333 ENOG4105CC9 acyl-Coa dehydrogenase Y89_4334 ENOG4105E39 Enoyl-CoA hydratase Y89_4335 ENOG4105D2B acyl-CoA dehydrogenase Y89_4337 ENOG4107RGD Major Facilitator superfamily Y89_4338 ENOG410900P UPF0336 protein Y89_4339 ENOG4105CD5 CoA-binding domain protein Y89_4343 ENOG4107QJZ Glycosyl transferase, family 2 Y89_4345 ENOG4105CY0 Metallo-Beta-Lactamase Y89_4346 ENOG4105GJM (LipO)protein Y89_4347 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Y89_4349 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Y89_4351 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) Y89_4352 ENOG4105ERG peptidase m48, ste24p Y89_4354 ENOG4105DUM transcriptional regulator, lysR family Y89_4355 ENOG4105DDQ anthranilate synthase Y89_4356 ENOG4105CRQ synthase (Component I) Y89_4357 ENOG4105R2E Metallo-beta-lactamase superfamily Y89_4358 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Y89_4359 ENOG4108MJ1 3-oxoacyl-(ACP) synthase Y89_4361 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Y89_4362 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Y89_4363 ENOG4105CW0 outer membrane usher protein Y89_4364 ENOG4108AF8 Chaperone Y89_4370 ENOG4105CMM transposase Y89_4372 ENOG4108MA7 Inherit from COG: YD repeat protein Y89_4380 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Y89_4381 ENOG4105UFD tol-pal system protein YbgF Y89_4382 ENOG4105KCK Peptidoglycan-associated lipoprotein Y89_4383 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Y89_4385 ENOG4105M8F Biopolymer transport protein exbD tolR Y89_4386 ENOG4105E02 MotA TolQ exbB proton channel Y89_4387 ENOG4107YD3 Thioesterase Y89_4391 ENOG4105CDY transcriptional regulatory protein Y89_4394 ENOG4105VEQ Cold shock protein Y89_4402 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Y89_4403 ENOG4105R2R Thioredoxin Y89_4408 ENOG4105CS1 NAD(P)H quinone oxidoreductase Y89_4411 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) Y89_4414 ENOG4108V3E phosphoribosylglycinamide formyltransferase Y89_4422 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme Y89_4424 ENOG4105DXN mazG family Y89_4425 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Y89_4427 ENOG4105C6T cysteine synthase Y89_4428 ENOG4107RNH Outer membrane receptor FepA Y89_4429 ENOG410804D Sensor Signal Transduction Histidine Kinase Y89_4431 ENOG4105BZU Histidine kinase Y89_4432 ENOG4105C5I Dehydrogenase Y89_4435 ENOG4105E68 Sulfatase Y89_4441 ENOG4108VKM cytochrome b561 Y89_4443 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Y89_4444 ENOG4108W15 Protein of unknown function (DUF1456) Y89_4446 ENOG4105CJW magnesium transporter Y89_4453 ENOG4108XTP Transcriptional regulator Y89_4455 ENOG4105CFH Aspartokinase Y89_4456 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Y89_4457 ENOG4105C5W Aldolase Y89_4461 ENOG4105C26 Dehydrogenase Y89_4462 ENOG4105F4X arginine Y89_4463 ENOG4108T2Z Arginine Y89_4464 ENOG4105C8Y Acetylornithine aminotransferase Y89_4466 ENOG4105ECQ AraC Family Transcriptional Regulator Y89_4467 ENOG4108JEH abc transporter atp-binding protein Y89_4470 ENOG4105DSP amino acid AbC transporter Y89_4471 ENOG4105E89 ABC transporter Y89_4472 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Y89_4473 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Y89_4474 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ Y89_4475 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Y89_4476 ENOG4105CI0 Citrate lyase Y89_4479 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase Y89_4480 ENOG4105C1G acyl-Coa dehydrogenase Y89_4481 ENOG4108M9J MaoC like domain protein Y89_4483 ENOG4105EJC lysr family transcriptional regulator Y89_4486 ENOG4108JU8 Transcriptional regulator Y89_4487 ENOG4105MIR Phenylalanine 4-monooxygenase Y89_4489 ENOG4105CGF Aromatic amino acid aminotransferase Y89_4490 ENOG41061WM D-Alanyl-D-Alanine Y89_4491 ENOG4108YZN class I peptide chain release factor Y89_4492 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Y89_4493 ENOG4105C85 amino acid Y89_4494 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Y89_4499 ENOG4105BZU Histidine kinase Y89_4500 ENOG4105BZ1 (ABC) transporter Y89_4503 ENOG4105M85 Bola protein Y89_4506 ENOG4105C9Q fumarate hydratase class II Y89_4508 ENOG4108M1A Chitin-binding protein Y89_4511 ENOG4105C3M thioredoxin reductase Y89_4512 ENOG4105D3R alkyl hydroperoxide reductase Y89_4513 ENOG4105BZU Histidine kinase Y89_4515 ENOG4107R72 Ceramidase Y89_4516 ENOG4105HSS phospholipase C Y89_4519 ENOG4108RMV DegV Family Y89_4521 ENOG4108WUH Transcriptional regulator, TetR family Y89_4522 ENOG4108V06 Glutathione peroxidase Y89_4523 ENOG4108YZY peptidylprolyl cis-trans isomerase Y89_4525 ENOG4105C6K Malic enzyme Y89_4526 ENOG4106HNH Acyl-transferase Y89_4527 ENOG4108ZG0 Ompa motb domain protein Y89_4528 ENOG4105C5X domain protein Y89_4529 ENOG4108ZX5 transcriptional regulator Y89_4531 ENOG4106HB6 Alpha beta hydrolase Y89_4532 ENOG4108IG5 Transcriptional regulator Y89_4535 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y89_4541 ENOG4105DUM transcriptional regulator, lysR family Y89_4542 ENOG4105DUM transcriptional regulator, lysR family Y89_4544 ENOG4105C92 Aminotransferase class V Y89_4547 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Y89_4548 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Y89_4550 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase Y89_4553 ENOG4105CV8 reductase Y89_4558 ENOG4105C0D helicase Y89_4559 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase Y89_4560 ENOG4105DRR Transcriptional regulator, GntR family Y89_4561 ENOG4105CR4 methylisocitrate lyase Y89_4562 ENOG4105BZN citrate synthase Y89_4563 ENOG4108I0Z Aconitate hydratase Y89_4564 ENOG4105C7F AcnD-accessory protein PrpF Y89_4565 ENOG4105DXD 2-methylcitrate dehydratase Y89_4568 ENOG4105C85 amino acid Y89_4572 ENOG4105KPY Small multidrug resistance protein Y89_4574 ENOG4105ETT transcriptional Regulator, LysR family Y89_4575 ENOG4105CK7 Sodium proline symporter Y89_4576 ENOG4105C26 Dehydrogenase Y89_4577 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Y89_4579 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Y89_4590 ENOG4105C3F Signal peptidase i Y89_4592 ENOG4105C0H protease Y89_4594 ENOG4105VQK sigma E regulatory protein, MucB RseB Y89_4595 ENOG41069E1 anti sigma-E protein RseA Y89_4596 ENOG4105EMN RNA polymerase sigma factor Y89_4597 ENOG4108IYU L-aspartate oxidase Y89_4599 ENOG4105Y75 tpr repeat protein Y89_4600 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Y89_4604 ENOG4105EPF Outer membrane porin Y89_4608 ENOG4108KK1 membrane protein AbrB duplication Y89_4610 ENOG4107RBI VanW family Y89_4612 ENOG4105C26 Dehydrogenase Y89_4613 ENOG4105C1G acyl-Coa dehydrogenase Y89_4614 ENOG4105E39 Enoyl-CoA hydratase Y89_4616 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Y89_4618 ENOG4108RYK Nad-dependent epimerase dehydratase Y89_4619 ENOG4105EUZ Beta-lactamase domain protein Y89_4628 ENOG4105I08 Pseudouridine synthase Y89_4631 ENOG4108YI3 3-hydroxyacyl-CoA-acyl carrier protein transferase Y89_4632 ENOG4105DFP Integrase Y89_4635 ENOG4107QJE Chromosome Partitioning Protein Y89_4642 ENOG4107YH6 single-stranded DNA-binding protein Y89_4643 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Y89_4675 ENOG4105W5Q DNA repair protein (RadC Y89_4682 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression Y89_4694 ENOG4108C33 Resolvase Y89_4697 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Y89_4712 ENOG4108HFV Y89_4714 ENOG4105C0D helicase Y89_4716 ENOG4106NZI LysR family Transcriptional regulator Y89_4725 ENOG4105EGI Transcriptional regulator Y89_4727 ENOG4105EQK -acetyltransferase Y89_4728 ENOG4105K64 Glycosyl transferase, family 2 Y89_4729 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Y89_4730 ENOG4105CSH Transporter Y89_4733 ENOG4107RSM transcriptional regulator Y89_4735 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Y89_4740 ENOG4105SG9 biopolymer transport protein, ExbD Y89_4741 ENOG4105E02 MotA TolQ exbB proton channel Y89_4742 ENOG4105D5K Hemolysin activator protein Y89_4746 ENOG4105D7Q type ii secretion system Y89_4747 ENOG4107QHF type ii secretion system protein e Y89_4748 ENOG4105GVR general secretion pathway protein D Y89_4752 ENOG4108VAU general secretion pathway protein G Y89_4753 ENOG4105X5Z General secretion pathway protein I Y89_4756 ENOG4108WWZ General secretion pathway protein J Y89_4761 ENOG4108YNN Heme oxygenase Y89_4764 ENOG4105C0B DNA polymerase III (alpha subunit) Y89_4765 ENOG4107RH8 nuclease SbcCD subunit D Y89_4766 ENOG4105EYH Exonuclease Y89_4767 ENOG4107QYX exodeoxyribonuclease v alpha Y89_4768 ENOG4107QKA exodeoxyribonuclease V beta Y89_4769 ENOG4105DSY exodeoxyribonuclease V, gamma Y89_4770 ENOG4108KMH lipoate-protein ligase a Y89_4771 ENOG410631K Membrane Y89_4774 ENOG4105C8Q Methyl-accepting chemotaxis Y89_4776 ENOG4105CJ3 phosphate transporter Y89_4780 ENOG4108ZXC Two component transcriptional regulator, luxr family Y89_4783 ENOG4105VK0 repeat-containing protein Y89_4791 ENOG4105C8Q Methyl-accepting chemotaxis Y89_4792 ENOG4105D7A ATP-binding protein Y89_4793 ENOG4105C8Q Methyl-accepting chemotaxis Y89_4794 ENOG4105C8Q Methyl-accepting chemotaxis Y89_4801 ENOG4105CJB Exodeoxyribonuclease I Y89_4807 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Y89_4813 ENOG4105Q9Y Universal stress protein Y89_4814 ENOG4105CA9 Pyruvate kinase Y89_4815 ENOG4105E39 Enoyl-CoA hydratase Y89_4817 ENOG4105BZU Histidine kinase Y89_4818 ENOG4107GFK fumarate Y89_4819 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Y89_4821 ENOG4107R7Y intracellular protease Pfpi family Y89_4824 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Y89_4827 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Y89_4828 ENOG4105CSH Transporter Y89_4829 ENOG4105CH2 amidohydrolase Y89_4832 ENOG4105FQP Beta-lactamase Y89_4840 ENOG4105F27 Major Facilitator Y89_4841 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_4842 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) Y89_4844 ENOG4105XFK Ferrous iron transport protein A Y89_4847 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase Y89_4852 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Y89_4856 ENOG4108V0P LemA family Y89_4861 ENOG410624X efflux transporter, rnd family, mfp subunit Y89_4862 ENOG4105BZS acriflavin resistance protein Y89_4863 ENOG4107RH7 Nicotinate phosphoribosyltransferase Y89_4865 ENOG4105FQR PH-inducible protein involved in stress response Y89_4868 ENOG4106F60 Histidine kinase Y89_4869 ENOG4105ETX regulatoR Y89_4876 ENOG4105FS0 cytoplasmic membrane protein Y89_4883 ENOG4105D64 Mechanosensitive ion channel Y89_4884 ENOG4108VPT UPF0234 protein Y89_4885 ENOG4108VYJ response regulator receiver protein Y89_4886 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Y89_4888 ENOG4108WBT adenosyltransferase Y89_4889 ENOG4105M6F mutator MutT protein Y89_4891 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Y89_4893 ENOG4105E4C Lytic transglycosylase catalytic Y89_4896 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Y89_4897 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Y89_4898 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) Y89_4899 ENOG4105CPF Cell wall formation (By similarity) Y89_4902 ENOG4105CNI cell division protein FtsW Y89_4903 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Y89_4905 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Y89_4906 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Y89_4907 ENOG4105CJN penicillin-binding protein Y89_4911 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Y89_4912 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) Y89_4915 ENOG4105W4M Transport-associated protein Y89_4916 ENOG4105KB2 stringent starvation protein b Y89_4917 ENOG4107MKT Stringent starvation protein a Y89_4918 ENOG4105EIX cytochrome c1 Y89_4919 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Y89_4920 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Y89_4923 ENOG4105CPC Aldo Keto reductase Y89_4924 ENOG4105C1G acyl-Coa dehydrogenase Y89_4927 ENOG4105D6Z AFG1 family ATPase Y89_4928 ENOG4105C31 Tryptophanyl-tRNA synthetase Y89_4929 ENOG4105DHZ alpha beta Y89_4931 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) Y89_4933 ENOG4105CVE Lytic murein transglycosylase Y89_4934 ENOG4107QNR UPF0135 protein Y89_4935 ENOG4105C0H protease Y89_4936 ENOG4105CIH Imidazole acetol-phosphate transaminase Y89_4937 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Y89_4943 ENOG4107PE3 Mammalian cell entry related domain protein Y89_4944 ENOG4105CY3 ABC transporter, permease Y89_4945 ENOG4105DHJ ABC, transporter Y89_4947 ENOG4105C2X Arabinose 5-phosphate isomerase Y89_4948 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Y89_4951 ENOG4108IUZ ABC transporter Y89_4952 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y89_4953 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA Y89_4954 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Y89_4955 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Y89_4956 ENOG41080Z8 PHOSPHOCARRIER protein Y89_4958 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Y89_4960 ENOG4105C9Q fumarate hydratase class II Y89_4962 ENOG4105CMS peptidase U62, modulator of DNA gyrase Y89_4963 ENOG4105N42 UPF0307 protein Y89_4964 ENOG4105D1U peptidase U62 modulator of DNA gyrase Y89_4967 ENOG4105C03 ribonuclease Y89_4968 ENOG4108Z03 MAF-like protein Y89_4970 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) Y89_4971 ENOG4105DFF Rod shape-determining protein mreb Y89_4972 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Y89_4973 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Y89_4975 ENOG4105K6T rare lipoprotein A Y89_4976 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Y89_4977 ENOG4105EDV vault protein Y89_4978 ENOG41081SK signal peptide protein Y89_4979 ENOG4107S52 alpha-2-macroglobulin domain protein Y89_4980 ENOG4108QJJ Protein of unknown function (DUF1175) Y89_4981 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) Y89_4982 ENOG4105EDV vault protein Y89_4983 ENOG4108UYB regulatoR Y89_4984 ENOG4105TX3 Histidine kinase Y89_4986 ENOG4105DEF Extracellular solute-binding protein, family 5 Y89_4988 ENOG4105DEF Extracellular solute-binding protein, family 5 Y89_4989 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Y89_4990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Y89_4991 ENOG4105C3U ABC transporter Y89_4992 ENOG4108JQ7 (ABC) transporter Y89_4993 ENOG4108NIW Leucine export protein LeuE Y89_4994 ENOG4105EW9 transcriptional regulator AsnC family Y89_4995 ENOG4107R7A Allophanate hydrolase subunit 2 Y89_4997 ENOG4105E7W lamb ycsf family protein Y89_4999 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Y89_5000 ENOG4108ESX Receptor Y89_5001 ENOG4107E2E PKHD-type hydroxylase Y89_5003 ENOG4105DIJ Phosphoethanolamine transferase Y89_5005 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Y89_5006 ENOG4105C8Q Methyl-accepting chemotaxis Y89_5010 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Y89_5011 ENOG4108KU3 Integrase Y89_5023 ENOG4108UK2 deaminase Y89_5032 ENOG4105CN7 Flagellar biosynthetic protein FliP Y89_5033 ENOG4105VS8 Flagellar biosynthetic protein fliq Y89_5034 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Y89_5035 ENOG4105D00 flagellar biosynthetic protein flhB Y89_5037 ENOG4107QHF type ii secretion system protein e Y89_5039 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) Y89_5040 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Y89_5049 ENOG4105CEP NADH dehydrogenase Y89_5050 ENOG4105D6Z AFG1 family ATPase Y89_5053 ENOG4107QJE Chromosome Partitioning Protein Y89_5060 ENOG4105CDU Replicative dna helicase Y89_5082 ENOG4105C0D helicase Y89_5083 ENOG4105YES addiction module antidote protein Y89_5088 ENOG4107QHF type ii secretion system protein e Y89_5091 ENOG4107QHF type ii secretion system protein e Y89_5116 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Y89_5138 ENOG4105X54 addiction module antidote protein Y89_5139 ENOG4105VV5 Plasmid stabilization system Y89_5148 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y89_5149 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Y89_5150 ENOG4105C34 Pseudouridine synthase Y89_5151 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Y89_5153 ENOG4107TUY Histidine kinase Y89_5154 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_5155 ENOG4105MWK D-amino acid dehydrogenase, small subunit Y89_5165 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase Y89_5167 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Y89_5168 ENOG4105DTN riboflavin biosynthesis protein ribF Y89_5169 ENOG4105CJR Integral membrane protein (MviN Y89_5171 ENOG4108RH0 Crea protein Y89_5176 ENOG4105EAH synthase Y89_5179 ENOG4108V1T peptidylprolyl cis-trans isomerase Y89_5181 ENOG4108TEB UPF0114 protein Y89_5183 ENOG4105DAN ATP-dependent protease Y89_5188 ENOG4105CYB regulatoR Y89_5190 ENOG4105E0Y RtcB Protein Y89_5191 ENOG410756H nucleotidyltransferase Y89_5194 ENOG4105CA0 peroxidase Y89_5195 ENOG4105D82 Glutamate dehydrogenase Y89_5200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y89_5201 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y89_5202 ENOG4105C5H ABC transporter Y89_5204 ENOG4105RJZ Transcriptional regulator Y89_5205 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y89_5206 ENOG4105BZS acriflavin resistance protein Y89_5207 ENOG4105C1P efflux transporter, rnd family, mfp subunit Y89_5208 ENOG4105RJZ Transcriptional regulator Y89_5209 ENOG4105BZU Histidine kinase Y89_5210 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Y89_5212 ENOG4105CKI cobalamin synthesis protein Y89_5213 ENOG4105VCD cytoplasmic protein Y89_5214 ENOG4105D22 carbon starvation protein Y89_5217 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Y89_5221 ENOG4105CH6 catalase Y89_5223 ENOG4105DP0 ferredoxin-NADP reductase Y89_5224 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Y89_5225 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Y89_5227 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Y89_5228 ENOG4107TJ9 Cytochrome Y89_5235 ENOG4105C5I Dehydrogenase Y89_5237 ENOG4108IQI permease Y89_5241 ENOG4108K0D peptidase, M48 Y89_5242 ENOG4105C8Q Methyl-accepting chemotaxis Y89_5243 ENOG4108RAV Conserved protein Y89_5244 ENOG4105KT7 mgtC SapB transporter Y89_5251 ENOG4105DWT malate dehydrogenase (quinone) Y89_5256 ENOG4108UGV hypoxanthine phosphoribosyltransferase Y89_5258 ENOG4105C2W permease Y89_5267 ENOG4105ECP epimerase Y89_5268 ENOG4108QDE fad dependent oxidoreductase Y89_5270 ENOG4108XDN Transcriptional regulator Y89_5271 ENOG4105CVP deoxyribo-dipyrimidine photolyase Y89_5272 ENOG41061N2 exported protein Y89_5274 ENOG4105D06 uba thif-type nad fad binding protein Y89_5275 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Y89_5276 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Y89_5278 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein Y89_5280 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Y89_5284 ENOG4105C3G gtp-binding protein Y89_5285 ENOG4105VDM plasmid maintenance system antidote protein, xre family Y89_5287 ENOG41077A9 carbonic anhydrase Y89_5289 ENOG410801F ribosomal-protein-alanine acetyltransferase Y89_5298 ENOG4107QKW extracellular solute-binding protein family 1 Y89_5299 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Y89_5300 ENOG4105DY2 Paraquat-inducible protein b Y89_5301 ENOG4105F1S paraquat-inducible protein a Y89_5302 ENOG4105H2K paraquat-inducible protein a Y89_5304 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Y89_5305 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Y89_5307 ENOG4108ZP8 Acetolactate synthase small subunit Y89_5308 ENOG4105C7K acetolactate synthase Y89_5310 ENOG4105WP7 tRNA pseudouridine synthase C Y89_5312 ENOG4105BZ4 penicillin-binding protein Y89_5319 ENOG4105EHG Permease protein Y89_5320 ENOG4107R4I Periplasmic binding protein Y89_5321 ENOG4106QJH hemin transport protein Y89_5322 ENOG4107ENK receptor Y89_5327 ENOG4105CHM Aminotransferase Y89_5329 ENOG4105CGZ zinc metallopeptidase Y89_5331 ENOG4105C7N Xanthine uracil vitamin C permease Y89_5335 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Y89_5338 ENOG4105BZU Histidine kinase Y89_5339 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_5340 ENOG4105DJ0 Poly(A) Polymerase Y89_5341 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Y89_5346 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Y89_5351 ENOG4105VDW Csbd family Y89_5352 ENOG4105W4M Transport-associated protein Y89_5355 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Y89_5358 ENOG4105CHV Transcription elongation factor NusA Y89_5362 ENOG4105EEI dihydropteroate synthase Y89_5363 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Y89_5365 ENOG4105HBR Rna-binding protein Y89_5367 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Y89_5368 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Y89_5369 ENOG4108NIW Leucine export protein LeuE Y89_5370 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Y89_5375 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Y89_5376 ENOG41090R7 Ferric uptake Y89_5377 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Y89_5379 ENOG4108Z1B Cyclase dehydrase Y89_5381 ENOG41073TP transcriptional regulator Y89_5382 ENOG4105DAA L-lactate Y89_5386 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Y89_5388 ENOG4105XJC Two component transcriptional regulator (Winged helix family Y89_5389 ENOG4105DHQ Histidine kinase Y89_5390 ENOG4108Z6Z Transcriptional regulator Y89_5392 ENOG4108594 Permease of the drug metabolite transporter Y89_5394 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Y89_5396 ENOG4105FDR Membrane Y89_5399 ENOG4105CHR reductase Y89_5400 ENOG4108ZX5 transcriptional regulator Y89_5403 ENOG4106371 Methyltransferase Y89_5409 ENOG4105PHD The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Y89_5410 ENOG4108MTT Glutamate-rich protein grpB Y89_5416 ENOG410839U amino acid Y89_5417 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Y89_5419 ENOG4105EM7 Selenocysteine-specific translation elongation factor Y89_5421 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) Y89_5422 ENOG4108MG3 formate dehydrogenase Y89_5423 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Y89_5426 ENOG4107IFA Lipase (EC 3.1.1.3) Y89_5427 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_5456 ENOG4108QUU Morphogenesis Protein Y89_5458 ENOG4105CF2 Mu-like prophage FluMu protein GP28 Y89_5464 ENOG4107SC1 transglycosylase Y89_5487 ENOG4105CKK Glycosyl transferase, family 2 Y89_5489 ENOG4107R73 Mate efflux family protein Y89_5491 ENOG4105EAM Na Pi-cotransporter Y89_5494 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Y89_5496 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase Y89_5498 ENOG4107QN2 dihydrolipoyl dehydrogenase Y89_5501 ENOG4105EMU Dehydrogenase Y89_5502 ENOG4108UT2 hemolysin iii Y89_5503 ENOG4108I0N Transporter, RarD family, DMT superfamily protein Y89_5505 ENOG410642S Nicotianamine synthase protein Y89_5508 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) Y89_5509 ENOG4108ZJT translation initiation factor, Sui1 Y89_5510 ENOG4105PTV Nudix Hydrolase Y89_5514 ENOG4108W2P Methyl-accepting chemotaxis Y89_5515 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Y89_5516 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Y89_5517 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Y89_5518 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Y89_5521 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Y89_5522 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) Y89_5524 ENOG4105C12 Phosphoribosylglycinamide synthetase Y89_5525 ENOG4105BZU Histidine kinase Y89_5526 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Y89_5527 ENOG41083Z3 extracellular ligand-binding receptor Y89_5528 ENOG4105C32 Amino acid ABC transporter (Permease) Y89_5529 ENOG4105CNN ABC, transporter Y89_5530 ENOG4105C0Z ABC transporter Y89_5531 ENOG4108IV0 ABC, transporter Y89_5533 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Y89_5535 ENOG4108Z7F N-acetyltransferase Y89_5537 ENOG4105CQM Urea amidohydrolase subunit alpha Y89_5539 ENOG4105KSC Transcriptional regulator, TraR DksA family Y89_5542 ENOG4105R8A Heat shock protein Y89_5548 ENOG41066T0 asmA family Y89_5549 ENOG4108UQY Iron-storage protein Y89_5551 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Y89_5552 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) Y89_5564 ENOG4108S3W Anti-feci sigma factor, fecr Y89_5565 ENOG4108SF5 RNA Polymerase Y89_5567 ENOG41090KI Outer membrane porin Y89_5571 ENOG4105FP9 thiamine pyrophosphate Y89_5572 ENOG4108PTX LysR family Transcriptional regulator Y89_5573 ENOG4105D2S major facilitator superfamily Y89_5577 ENOG4105EMU Dehydrogenase Y89_5578 ENOG4105CIF Ornithine Cyclodeaminase Y89_5579 ENOG4108IV0 ABC, transporter Y89_5580 ENOG4105C0Z ABC transporter Y89_5581 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Y89_5582 ENOG4105C32 Amino acid ABC transporter (Permease) Y89_5584 ENOG4105ETT transcriptional Regulator, LysR family Y89_5587 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Y89_5589 ENOG4107RH7 Nicotinate phosphoribosyltransferase Y89_5592 ENOG41090JD Blue (Type 1) copper domain protein Y89_5593 ENOG4108URH decarboxylase Y89_5594 ENOG4108K5P (LipO)protein Y89_5595 ENOG4105D64 Mechanosensitive ion channel Y89_5598 ENOG4105CCT upf0313 protein Y89_5599 ENOG4105BZU Histidine kinase Y89_5600 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Y89_5601 ENOG4105CDU Replicative dna helicase Y89_5606 ENOG4105C2N RNA methyltransferase TrmH family group 3 Y89_5607 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Y89_5611 ENOG4105EPW hflc protein Y89_5612 ENOG4107QJR hflk protein Y89_5613 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Y89_5617 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Y89_5618 ENOG4105K8N protein family UPF0079, ATPase Y89_5619 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Y89_5620 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Y89_5622 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Y89_5623 ENOG4105ER2 Ompa motb domain protein Y89_5624 ENOG4107RD7 Flagellar Motor Protein, MotA Y89_5626 ENOG4105KHC sulfurtransferase Y89_5629 ENOG4105BZU Histidine kinase Y89_5630 ENOG4105EAC phosphoserine phosphatase Y89_5632 ENOG4105S2T inner membrane protein YbcI Y89_5634 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y89_5635 ENOG4108WIW Aspartyl protease Y89_5637 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y89_5638 ENOG4105IPS esterase Y89_5639 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Y89_5641 ENOG41087AY ADP-Ribose pyrophosphatase Y89_5644 ENOG4105DFG type I secretion outer membrane protein Y89_5645 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF Y89_5646 ENOG4105CHM Aminotransferase Y89_5647 ENOG4105C7K acetolactate synthase Y89_5648 ENOG4105CMV Succinyl-CoA synthetase subunit beta Y89_5649 ENOG4105C1G acyl-Coa dehydrogenase Y89_5650 ENOG4105E39 Enoyl-CoA hydratase Y89_5651 ENOG4108IQI permease Y89_5652 ENOG4105BZU Histidine kinase Y89_5654 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Y89_5657 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_5659 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Y89_5660 ENOG4106P55 Transcriptional regulator Y89_5661 ENOG410814C multidrug resistance protein Y89_5663 ENOG4107SET aldo keto reductase Y89_5665 ENOG4105C1G acyl-Coa dehydrogenase Y89_5666 ENOG4105C1G acyl-Coa dehydrogenase Y89_5667 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Y89_5668 ENOG4105BZ1 (ABC) transporter Y89_5671 ENOG4108SHN Glycosyl transferase, family 2 Y89_5676 ENOG4107TAE Glycosyl transferase (Group 1 Y89_5681 ENOG4107543 (lipo)polysaccharide Y89_5682 ENOG4107RJ7 Glycosyl transferase (Group 1 Y89_5683 ENOG4105D16 lipopolysaccharide heptosyltransferase i Y89_5684 ENOG4105XA0 heptosyltransferase ii Y89_5685 ENOG4105CM2 brancheD-chain amino acid aminotransferase Y89_5686 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Y89_5687 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Y89_5688 ENOG4107QSN dihydrolipoamide acetyltransferase Y89_5689 ENOG4105BZU Histidine kinase Y89_5691 ENOG4105D6S protein involved in catabolism of external DNA Y89_5692 ENOG4105CSU acyl-Coa dehydrogenase Y89_5693 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) Y89_5694 ENOG4105EGS Mechanosensitive ion channel Y89_5696 ENOG410635A Membrane Y89_5697 ENOG4108IQK o-acetylhomoserine Y89_5700 ENOG4107SKI cobyrinic Acid a,c-diamide synthase Y89_5701 ENOG4106NZI LysR family Transcriptional regulator Y89_5702 ENOG4105D94 Major Facilitator Superfamily Y89_5707 ENOG4105BZ8 glutamate synthase Y89_5708 ENOG4105CBC glutamate synthase Y89_5710 ENOG4105D49 3-dehydroquinate synthase Y89_5712 ENOG4105E4G Type IV pilus Y89_5717 ENOG4108JQC penicillin-binding protein 1A Y89_5718 ENOG4105C6K Malic enzyme Y89_5722 ENOG4105C25 Primosomal protein n' Y89_5723 ENOG4105C75 arginyL-tRNA synthetase Y89_5737 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Y89_5744 ENOG4105C8Q Methyl-accepting chemotaxis Y89_5745 ENOG41067ZM Uncharacterised protein family (UPF0158) Y89_5746 ENOG4105CDA abc transporter atp-binding protein Y89_5747 ENOG4105E5Q amino acid AbC transporter Y89_5748 ENOG4106PMH Extracellular solute-binding protein family 3 Y89_5753 ENOG4108Z4K mutator MutT protein Y89_5754 ENOG4107RP9 extracellular solute-binding protein, family 3 Y89_5755 ENOG4105KME endoribonuclease L-psp Y89_5756 ENOG4105MWK D-amino acid dehydrogenase, small subunit Y89_5760 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Y89_5763 ENOG4105CI2 imidazolone-5-propionate hydrolase Y89_5764 ENOG4105C84 Histidine ammonia-lyase Y89_5766 ENOG4108HQS Glycine betaine Y89_5768 ENOG4105C85 amino acid Y89_5770 ENOG4105ETS cytosine purines uracil thiamine allantoin Y89_5775 ENOG41090B9 response to stress Y89_5776 ENOG4105CZE histidine utilization repressor Y89_5777 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Y89_5782 ENOG4107XDR Lactoylglutathione lyase Y89_5783 ENOG4108FHP Autotransporter beta-domain Y89_5787 ENOG4108Z4X TRANSCRIPTIONal Y89_5790 ENOG4105C5F glutamine synthetase Y89_5792 ENOG4105D8X mechanosensitive ion channel Y89_5795 ENOG4105CUX Signal transduction histidine kinase Y89_5796 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_5799 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Y89_5801 ENOG4105VW4 glutaredoxin 3 Y89_5805 ENOG41063SB peptidase Y89_5806 ENOG4105CN1 protease Y89_5807 ENOG4105PXI polysaccharide deacetylase Y89_5812 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Y89_5815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Y89_5821 ENOG4105CEN a g-specific adenine glycosylase Y89_5823 ENOG4105D9R oxidoreductase Y89_5824 ENOG4106PGW Short-chain dehydrogenase reductase Sdr Y89_5826 ENOG4108JEH abc transporter atp-binding protein Y89_5827 ENOG4105E89 ABC transporter Y89_5831 ENOG4105K56 Transcriptional regulator Y89_5833 ENOG4105CW7 secretion protein, HlyD family Y89_5834 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y89_5846 ENOG4105DFP Integrase Y89_5847 ENOG4105C1B dTDP-glucose 4-6-dehydratase Y89_5848 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Y89_5850 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Y89_5851 ENOG4105CQZ Histidine kinase Y89_5852 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_5853 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Y89_5854 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ Y89_5855 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Y89_5856 ENOG4105D5Q Arginine ornithine antiporter Y89_5857 ENOG4105CEU Arginine dihydrolase Y89_5858 ENOG4105DBV ornithine carbamoyltransferase Y89_5859 ENOG4105C5B carbamate kinase Y89_5860 ENOG4107RX2 synthase Y89_5861 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Y89_5862 ENOG4107RK2 ADP-ribose diphosphatase NudE Y89_5863 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 Y89_5864 ENOG4109066 lysm domain bon superfamily protein Y89_5865 ENOG4105C5Q Transcriptional regulator Y89_5866 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Y89_5870 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Y89_5873 ENOG4105C0A alcohol dehydrogenase Y89_5874 ENOG4105CSU acyl-Coa dehydrogenase Y89_5875 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y89_5882 ENOG4105VEJ Heat shock protein Y89_5883 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Y89_5885 ENOG4107WMG L,D-carboxypeptidase Y89_5886 ENOG4105E0F Histidine kinase Y89_5887 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Y89_5888 ENOG4105BZM domain protein Y89_5890 ENOG4105D9M gamma-glutamylcysteine synthetase Y89_5894 ENOG4105CJ3 phosphate transporter Y89_5895 ENOG4107IX6 phosphate transport regulator Y89_5896 ENOG4105I7R Adenylate cyclase Y89_5897 ENOG4107QHF type ii secretion system protein e Y89_5900 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Y89_5901 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Y89_5902 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Y89_5903 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component Y89_5904 ENOG4107QKW extracellular solute-binding protein family 1 Y89_5905 ENOG4106NZI LysR family Transcriptional regulator Y89_5908 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family Y89_5910 ENOG4105D0A hydroxylase Y89_5911 ENOG4107RAQ aminopeptidase Y89_5914 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Y89_5915 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Y89_5918 ENOG4105CMI transporter Y89_5919 ENOG4105CJ1 ABC, transporter Y89_5920 ENOG4105D0S secretion protein (HlyD Y89_5923 ENOG4105CXY transporter Y89_5926 ENOG4105EXC Acyl-transferase Y89_5927 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Y89_5928 ENOG4105K63 Thioredoxin Y89_5929 ENOG4105C9X ppx gppa phosphatase Y89_5931 ENOG4105D52 delta-aminolevulinic acid dehydratase Y89_5932 ENOG4105KHU inner membrane protein YohD Y89_5933 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain Y89_5934 ENOG4108VUY thioesterase Superfamily protein Y89_5936 ENOG4107SJW iron permease, FTR1 Y89_5937 ENOG410829K Lysine exporter protein (Lyse ygga) Y89_5938 ENOG4105EE5 Membrane protein terC Y89_5940 ENOG4105C5H ABC transporter Y89_5944 ENOG4105PBF Anti-RNA polymerase sigma 70 factor Y89_5945 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) Y89_5948 ENOG41076E6 Uroporphyrinogen-III Synthase Y89_5950 ENOG4108NEV two component transcriptional regulator, LytTR family Y89_5951 ENOG4108HRK Histidine kinase Y89_5952 ENOG4105CH7 arginosuccinase Y89_5956 ENOG4108WC9 type VI secretion system effector, hcp1 family Y89_5957 ENOG4107QUT magnesium and cobalt transport protein CorA Y89_5961 ENOG4107T0K Adenylate cyclase Y89_5963 ENOG4105NXH GreA GreB family elongation factor Y89_5964 ENOG4105XQ6 frataxin-like protein Y89_5966 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Y89_5975 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Y89_5976 ENOG4105BZU Histidine kinase Y89_5977 ENOG4108YZA Nitrogen regulatory protein pii Y89_5978 ENOG4105W0Z cytoplasmic protein Y89_5979 ENOG4105C0P Mg chelatase subunit ChlI Y89_5992 ENOG4105EMU Dehydrogenase Y89_5993 ENOG4105EMY transcriptional regulator Y89_5999 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_6000 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Y89_6009 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Y89_6010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y89_6028 ENOG4105C0P Mg chelatase subunit ChlI Y89_6029 ENOG4105C94 Transporter Y89_6031 ENOG4105ETT transcriptional Regulator, LysR family Y89_6032 ENOG4107QI1 Mate efflux family protein Y89_6033 ENOG4105BZU Histidine kinase Y89_6034 ENOG4105C4R Atp-dependent dna helicase Y89_6035 ENOG4105C7K acetolactate synthase Y89_6036 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) Y89_6037 ENOG4105CYC Transferase Y89_6038 ENOG4105MPD Cytochrome Y89_6039 ENOG4107VRI Transcriptional regulator Y89_6040 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Y89_6041 ENOG4105M4H endoribonuclease L-psp Y89_6042 ENOG4105MWK D-amino acid dehydrogenase, small subunit Y89_6044 ENOG410689M (LipO)protein Y89_6046 ENOG4105EW9 transcriptional regulator AsnC family Y89_6047 ENOG4105CJP fad dependent oxidoreductase Y89_6048 ENOG4107RZC phospholipase d Y89_6049 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y89_6050 ENOG4105C26 Dehydrogenase Y89_6051 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Y89_6053 ENOG4105W0E 50S ribosomal protein L33 Y89_6055 ENOG4105DEF Extracellular solute-binding protein, family 5 Y89_6058 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Y89_6066 ENOG4105MPD Cytochrome Y89_6070 ENOG4105CGK Exodeoxyribonuclease III Y89_6073 ENOG4105DSJ YicC domain protein Y89_6074 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Y89_6076 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Y89_6077 ENOG4105KME endoribonuclease L-psp Y89_6082 ENOG4105C5Q Transcriptional regulator Y89_6083 ENOG4105CB5 ATP-dependent DNA helicase recG Y89_6086 ENOG4105NYX DNA-binding protein Y89_6087 ENOG4107QZF nitrite reductase NADPH large subunit Y89_6088 ENOG4105VCQ rubredoxin Y89_6090 ENOG4108ZJF Glcg protein Y89_6091 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Y89_6092 ENOG4105EU8 FAD linked oxidase domain protein Y89_6093 ENOG4105CQB FAD linked oxidase domain protein Y89_6094 ENOG4108KWP DNA-binding transcriptional regulator GlcC Y89_6095 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) Y89_6098 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Y89_6099 ENOG4105BZU Histidine kinase Y89_6100 ENOG4105C37 (CBS) domain Y89_6101 ENOG4105DR5 peptidase Y89_6102 ENOG4108VYJ response regulator receiver protein Y89_6103 ENOG4108UTW Plays a role in the regulation of phosphate uptake Y89_6104 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Y89_6105 ENOG4105C8U phosphate abc transporter Y89_6106 ENOG4105C8U phosphate abc transporter Y89_6108 ENOG4105CSH Transporter Y89_6109 ENOG4105NAU thioesterase Superfamily protein Y89_6113 ENOG4105C94 Transporter Y89_6114 ENOG4108IJ7 Glycine betaine Y89_6115 ENOG4108HQS Glycine betaine Y89_6117 ENOG4105EJQ L-serine dehydratase Y89_6118 ENOG4105ECQ AraC Family Transcriptional Regulator Y89_6120 ENOG4105DUM transcriptional regulator, lysR family Y89_6121 ENOG4105HMI Membrane Y89_6124 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) Y89_6125 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Y89_6127 ENOG4105ECQ AraC Family Transcriptional Regulator Y89_6128 ENOG4105CWC Acetylornithine deacetylase Y89_6130 ENOG4105KME endoribonuclease L-psp Y89_6131 ENOG4105H3G oxidoreductase Y89_6134 ENOG4108IGT Dipeptidase Y89_6137 ENOG4105DF6 Fe-S oxidoreductase Y89_6141 ENOG4105VMP Transcriptional regulator Y89_6149 ENOG4105DVW rieske (2Fe-2S) Y89_6150 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Y89_6152 ENOG4105C5W Aldolase Y89_6154 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Y89_6160 ENOG4105E2A Dehydrogenase Y89_6161 ENOG4105DSB aldose 1-epimerase Y89_6164 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Y89_6165 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Y89_6167 ENOG4107YNJ LysR family Transcriptional regulator Y89_6168 ENOG4108IJ0 Aspartate ammonia-lyase Y89_6169 ENOG41066VF YeeE YedE family protein Y89_6174 ENOG4107QSA Oxaloacetate decarboxylase Y89_6175 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Y89_6176 ENOG4105DUM transcriptional regulator, lysR family Y89_6178 ENOG4106KNT transcriptional regulator Y89_6179 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Y89_6180 ENOG4105CFP Peptidase U32 Y89_6183 ENOG4105BZU Histidine kinase Y89_6184 ENOG4105C4R Atp-dependent dna helicase Y89_6186 ENOG4105CYC Transferase Y89_6189 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Y89_6191 ENOG4105EY8 ABC transporter Y89_6194 ENOG4105C0K Gdp-mannose 4,6-dehydratase Y89_6195 ENOG4108DMA Nad-dependent epimerase dehydratase Y89_6198 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Y89_6199 ENOG4105EXC Acyl-transferase Y89_6207 ENOG4105RK9 auxin efflux carrier Y89_6209 ENOG4105D4T Citrate transporter Y89_6210 ENOG4105EE5 Membrane protein terC Y89_6211 ENOG4108S2Y peptide Chain Release factor Y89_6214 ENOG4105EAM Na Pi-cotransporter Y89_6216 ENOG41090JX gCN5-related N-acetyltransferase Y89_6220 ENOG4105CK2 sodium dicarboxylate symporter Y89_6221 ENOG4108ZGU inhibitor of vertebrate lysozyme Y89_6223 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_6224 ENOG4105ES5 Histidine kinase Y89_6225 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase Y89_6226 ENOG41076UM multiple antibiotic resistance (MarC)-related protein Y89_6227 ENOG4105BZU Histidine kinase Y89_6230 ENOG4106RE7 Cytochrome Y89_6231 ENOG4105MPD Cytochrome Y89_6233 ENOG4105C2M dna polymerase I Y89_6235 ENOG4105CUV Homoserine Kinase Y89_6238 ENOG4105NXV High-affinity zinc uptake system protein Y89_6239 ENOG4105MYN Zinc uptake regulation protein Y89_6241 ENOG4105FAV ABC, transporter Y89_6244 ENOG4108UMI ABC transporter, permease Y89_6245 ENOG4105D01 (LipO)protein Y89_6250 ENOG4105CUB amino acid Y89_6251 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y89_6254 ENOG4108HWY Beta-lactamase Y89_6256 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) Y89_6258 ENOG4105CKD glutathione-regulated potassium-efflux system protein Y89_6261 ENOG4105CHR reductase Y89_6262 ENOG4105CFQ glutamine synthetase Y89_6263 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Y89_6264 ENOG4105CHR reductase Y89_6269 ENOG4105CKD glutathione-regulated potassium-efflux system protein Y89_6270 ENOG4105CSH Transporter Y89_6271 ENOG410822N TonB family Y89_6272 ENOG4105CKI cobalamin synthesis protein Y89_6276 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Y89_6278 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Y89_6281 ENOG4105CD3 dihydroorotase Y89_6286 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Y89_6287 ENOG41083B3 HAD-superfamily subfamily IB hydrolase Y89_6289 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Y89_6290 ENOG410804X Transcriptional regulator Y89_6301 ENOG41064MJ ATP synthase, subunit I Y89_6302 ENOG4105FA0 parb-like partition protein Y89_6303 ENOG4107QJE Chromosome Partitioning Protein Y89_6316 ENOG4105X54 addiction module antidote protein Y89_6323 ENOG4107QJE Chromosome Partitioning Protein Y89_6330 ENOG4105CDU Replicative dna helicase Y89_6350 ENOG4105C0D helicase Y89_6351 ENOG4105YES addiction module antidote protein Y89_6356 ENOG4107QHF type ii secretion system protein e Y89_6359 ENOG4107QHF type ii secretion system protein e Y89_6386 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation