locus-tag	class	description
B2J77_00005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B2J77_00010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B2J77_00015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B2J77_00020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B2J77_00025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B2J77_00030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B2J77_00035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B2J77_00045	COG0356	it plays a direct role in the translocation of protons across the membrane
B2J77_00050	COG3312	ion transport
B2J77_00055	COG1475	DNA binding
B2J77_00060	COG1192	Involved in chromosome partitioning
B2J77_00065	COG0357	Ribosomal RNA small subunit methyltransferase G
B2J77_00070	COG0445	tRNA wobble uridine modification
B2J77_00075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2J77_00080	COG0706	membrane insertase activity
B2J77_00085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B2J77_00090	COG0594	ribonuclease P activity
B2J77_00095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B2J77_00100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B2J77_00105	COG0592	DNA-directed DNA polymerase activity
B2J77_00110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B2J77_00115	COG0187	DNA topoisomerase II activity
B2J77_00120	COG4221	oxidoreductase activity
B2J77_00155	COG0477	Major facilitator Superfamily
B2J77_00165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B2J77_00170	COG0751	glycine-tRNA ligase activity
B2J77_00175	COG0752	glycyl-tRNA synthetase alpha subunit
B2J77_00180	COG2818	Glycosylase
B2J77_00195	COG0569	domain protein
B2J77_00200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B2J77_00205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B2J77_00210	COG0242	peptide deformylase activity
B2J77_00215	COG0758	DNA mediated transformation
B2J77_00220	COG0009	L-threonylcarbamoyladenylate synthase
B2J77_00235	COG0408	coproporphyrinogen oxidase activity
B2J77_00240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B2J77_00245	COG0659	secondary active sulfate transmembrane transporter activity
B2J77_00255	COG3119	arylsulfatase activity
B2J77_00270	COG0159	tryptophan synthase activity
B2J77_00275	COG0133	tryptophan synthase activity
B2J77_00290	COG3360	Dodecin
B2J77_00300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2J77_00305	COG1764	response to oxidative stress
B2J77_00335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B2J77_00340	COG0339	signal peptide processing
B2J77_00345	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B2J77_00360	COG4962	Type ii secretion system protein e
B2J77_00375	COG3451	type IV secretory pathway VirB4
B2J77_00470	COG0659	secondary active sulfate transmembrane transporter activity
B2J77_00490	COG2011	ABC-type metal ion transport system permease component
B2J77_00495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B2J77_00510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B2J77_00515	COG1121	(ABC) transporter
B2J77_00520	COG0735	belongs to the Fur family
B2J77_00525	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B2J77_00545	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B2J77_00560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B2J77_00570	COG3706	GGDEF domain
B2J77_00570	COG0745	RESPONSE REGULATOR receiver
B2J77_00575	COG3023	N-Acetylmuramoyl-L-alanine amidase
B2J77_00580	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B2J77_00585	COG5002	protein histidine kinase activity
B2J77_00590	COG2204	response regulator
B2J77_00615	COG1301	dicarboxylic acid transport
B2J77_00620	COG0700	Nucleoside recognition
B2J77_00635	COG1283	sodium-dependent phosphate transmembrane transporter activity
B2J77_00640	COG0861	Integral membrane protein TerC family
B2J77_00645	COG2851	Citrate transporter
B2J77_00675	COG0427	acetyl-CoA hydrolase
B2J77_00680	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B2J77_00685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B2J77_00690	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B2J77_00695	COG0583	DNA-binding transcription factor activity
B2J77_00700	COG1960	acyl-CoA dehydrogenase activity
B2J77_00705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2J77_00765	COG1595	DNA-templated transcription, initiation
B2J77_00770	COG1802	Transcriptional regulator
B2J77_00780	COG3300	MHYT domain
B2J77_00780	COG5001	Diguanylate cyclase
B2J77_00785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_00805	COG2175	clavaminate synthase activity
B2J77_00820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2J77_00840	COG1289	transmembrane transporter activity
B2J77_00850	COG1566	PFAM secretion protein HlyD family protein
B2J77_00870	COG0625	glutathione transferase activity
B2J77_00875	COG0165	Argininosuccinate lyase
B2J77_00885	COG0181	hydroxymethylbilane synthase activity
B2J77_00905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B2J77_00930	COG0488	(ABC) transporter
B2J77_00935	COG1280	lysine exporter protein (LysE YggA)
B2J77_00955	COG2814	Major facilitator Superfamily
B2J77_01005	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2J77_01015	COG0745	RESPONSE REGULATOR receiver
B2J77_01015	COG3706	GGDEF domain
B2J77_01030	COG2011	ABC-type metal ion transport system permease component
B2J77_01035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B2J77_01040	COG1464	Belongs to the NlpA lipoprotein family
B2J77_01075	COG1045	serine acetyltransferase
B2J77_01080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2J77_01085	COG2175	clavaminate synthase activity
B2J77_01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2J77_01095	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B2J77_01100	COG4521	taurine ABC transporter
B2J77_01110	COG0450	alkyl hydroperoxide reductase
B2J77_01115	COG0431	NADPH-dependent FMN reductase
B2J77_01120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2J77_01125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2J77_01130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2J77_01135	COG1116	anion transmembrane transporter activity
B2J77_01155	COG2918	glutathione biosynthetic process
B2J77_01165	COG2183	response to ionizing radiation
B2J77_01170	COG0745	RESPONSE REGULATOR receiver
B2J77_01180	COG0189	ligase activity
B2J77_01185	COG0189	ligase activity
B2J77_01185	COG4067	protein conserved in archaea
B2J77_01190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B2J77_01200	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B2J77_01205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B2J77_01225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B2J77_01230	COG1652	LysM domain
B2J77_01235	COG1011	Hydrolase
B2J77_01240	COG0494	nUDIX hydrolase
B2J77_01270	COG2957	Belongs to the agmatine deiminase family
B2J77_01290	COG2205	protein histidine kinase activity
B2J77_01295	COG0745	RESPONSE REGULATOR receiver
B2J77_01310	COG0596	Alpha beta hydrolase
B2J77_01315	COG2205	protein histidine kinase activity
B2J77_01360	COG4215	(ABC) transporter
B2J77_01395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B2J77_01400	COG1194	a g-specific adenine glycosylase
B2J77_01415	COG0131	Imidazoleglycerol-phosphate dehydratase
B2J77_01420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B2J77_01430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B2J77_01435	COG0107	imidazoleglycerol-phosphate synthase activity
B2J77_01440	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B2J77_01445	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_01450	COG1309	transcriptional regulator
B2J77_01455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2J77_01485	COG2861	carbohydrate metabolic process
B2J77_01490	COG0793	Belongs to the peptidase S41A family
B2J77_01495	COG4942	peptidase
B2J77_01500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B2J77_01505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2J77_01515	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B2J77_01520	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B2J77_01535	COG3852	Histidine kinase
B2J77_01550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2J77_01550	COG0301	tRNA thio-modification
B2J77_01580	COG0058	SHG alpha-glucan phosphorylase activity
B2J77_01585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B2J77_01605	COG0402	S-adenosylhomocysteine deaminase activity
B2J77_01610	COG2188	Transcriptional regulator
B2J77_01620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B2J77_01625	COG2986	histidine ammonia-lyase
B2J77_01635	COG1228	amidohydrolase
B2J77_01650	COG0596	Alpha beta hydrolase
B2J77_01655	COG1490	D-aminoacyl-tRNA deacylase activity
B2J77_01660	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B2J77_01665	COG2943	transferase activity, transferring hexosyl groups
B2J77_01675	COG0765	amino acid transport
B2J77_01680	COG1126	abc transporter atp-binding protein
B2J77_01690	COG0840	transmembrane signaling receptor activity
B2J77_01695	COG0840	transmembrane signaling receptor activity
B2J77_01710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B2J77_01715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B2J77_01720	COG0140	phosphoribosyl-ATP diphosphatase activity
B2J77_01725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B2J77_01730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B2J77_01740	COG2226	methyltransferase
B2J77_01765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B2J77_01770	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B2J77_01775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B2J77_01780	COG0540	Belongs to the ATCase OTCase family
B2J77_01785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B2J77_01790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B2J77_01795	COG1678	Uncharacterized ACR, COG1678
B2J77_01805	COG0189	ligase activity
B2J77_01840	COG1272	protein, Hemolysin III
B2J77_01845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B2J77_01860	COG3038	cytochrome b561
B2J77_01865	COG2353	YceI-like domain
B2J77_01870	COG0513	Belongs to the DEAD box helicase family
B2J77_01880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B2J77_01885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B2J77_01925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B2J77_01930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B2J77_01935	COG0640	Transcriptional regulator
B2J77_01940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B2J77_01950	COG0126	phosphoglycerate kinase activity
B2J77_01975	COG1451	nucleotide metabolic process
B2J77_01990	COG1289	transmembrane transporter activity
B2J77_01995	COG2081	HI0933 family
B2J77_02000	COG0513	Belongs to the DEAD box helicase family
B2J77_02005	COG0477	Major facilitator Superfamily
B2J77_02020	COG0583	DNA-binding transcription factor activity
B2J77_02030	COG1960	acyl-CoA dehydrogenase activity
B2J77_02035	COG0506	proline dehydrogenase activity
B2J77_02035	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B2J77_02035	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B2J77_02040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2J77_02045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B2J77_02050	COG2192	nodulation
B2J77_02055	COG0438	transferase activity, transferring glycosyl groups
B2J77_02075	COG1215	transferase activity, transferring glycosyl groups
B2J77_02095	COG1132	(ABC) transporter
B2J77_02100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B2J77_02100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2J77_02110	COG0667	Aldo Keto reductase
B2J77_02130	COG1519	Transferase
B2J77_02135	COG1538	Outer membrane efflux protein
B2J77_02140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B2J77_02155	COG0494	nUDIX hydrolase
B2J77_02165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B2J77_02170	COG3150	esterase
B2J77_02185	COG3577	Aspartyl protease
B2J77_02205	COG3830	Belongs to the UPF0237 family
B2J77_02205	COG0560	Phosphoserine phosphatase
B2J77_02210	COG0688	phosphatidylethanolamine metabolic process
B2J77_02225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B2J77_02235	COG1162	GTPase activity
B2J77_02240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B2J77_02245	COG2860	membrane
B2J77_02255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B2J77_02255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B2J77_02260	COG0802	atpase or kinase
B2J77_02265	COG0860	N-Acetylmuramoyl-L-alanine amidase
B2J77_02270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B2J77_02275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B2J77_02280	COG1923	regulation of RNA biosynthetic process
B2J77_02285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B2J77_02290	COG0330	HflC and HflK could
B2J77_02295	COG0330	HflC and HflK could
B2J77_02300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B2J77_02305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B2J77_02315	COG1178	ABC-type Fe3 transport system permease component
B2J77_02320	COG1840	ABC-type Fe3 transport system, periplasmic component
B2J77_02335	COG0557	exoribonuclease II activity
B2J77_02340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2J77_02345	COG0360	Binds together with S18 to 16S ribosomal RNA
B2J77_02350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B2J77_02360	COG0359	binds to the 23S rRNA
B2J77_02365	COG0305	Participates in initiation and elongation during chromosome replication
B2J77_02370	COG1032	radical SAM domain protein
B2J77_02380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B2J77_02385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B2J77_02410	COG0410	ABC transporter
B2J77_02415	COG4221	oxidoreductase activity
B2J77_02445	COG2982	Protein involved in outer membrane biogenesis
B2J77_02470	COG0443	Heat shock 70 kDa protein
B2J77_02475	COG0484	heat shock protein binding
B2J77_02480	COG0789	Transcriptional regulator
B2J77_02495	COG0411	ABC transporter
B2J77_02505	COG0559	Belongs to the binding-protein-dependent transport system permease family
B2J77_02520	COG1113	amino acid transport
B2J77_02550	COG0330	HflC and HflK could
B2J77_02565	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B2J77_02575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B2J77_02615	COG0151	Belongs to the GarS family
B2J77_02620	COG0138	bifunctional purine biosynthesis protein purh
B2J77_02630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B2J77_02640	COG2264	protein methyltransferase activity
B2J77_02655	COG1346	cytolysis
B2J77_02665	COG0586	Pfam SNARE associated Golgi protein
B2J77_02670	COG2094	Belongs to the DNA glycosylase MPG family
B2J77_02675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B2J77_02680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B2J77_02690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B2J77_02695	COG0768	penicillin binding
B2J77_02700	COG0772	Belongs to the SEDS family
B2J77_02705	COG2951	lytic endotransglycosylase activity
B2J77_02715	COG1686	Belongs to the peptidase S11 family
B2J77_02720	COG2921	Belongs to the UPF0250 family
B2J77_02725	COG0321	lipoyl(octanoyl) transferase activity
B2J77_02730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B2J77_02735	COG1619	proteins homologs of microcin C7 resistance protein MccF
B2J77_02740	COG2951	lytic endotransglycosylase activity
B2J77_02760	COG0495	leucyl-tRNA aminoacylation
B2J77_02775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B2J77_02780	COG4535	Mg2 and Co2 transporter CorC
B2J77_02785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B2J77_02790	COG1702	phosphate starvation-inducible protein PhoH
B2J77_02800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B2J77_02805	COG0352	thiamine-phosphate diphosphorylase activity
B2J77_02810	COG0351	phosphomethylpyrimidine kinase
B2J77_02815	COG3850	Histidine kinase
B2J77_02815	COG3437	response regulator, receiver
B2J77_02815	COG2205	protein histidine kinase activity
B2J77_02815	COG4999	Histidine kinase
B2J77_02830	COG1960	acyl-CoA dehydrogenase activity
B2J77_02835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2J77_02850	COG1522	sequence-specific DNA binding
B2J77_02870	COG1643	Atp-dependent helicase
B2J77_02880	COG0531	amino acid
B2J77_02890	COG2197	response regulator
B2J77_02900	COG3416	Protein conserved in bacteria
B2J77_02910	COG1199	ATP-dependent helicase activity
B2J77_02910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2J77_02915	COG0697	spore germination
B2J77_02920	COG0513	Belongs to the DEAD box helicase family
B2J77_02930	COG0123	including yeast histone deacetylase and acetoin utilization protein
B2J77_02945	COG1946	Acyl-CoA thioesterase
B2J77_02965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2J77_02970	COG1120	ATPase activity
B2J77_02980	COG1366	Belongs to the anti-sigma-factor antagonist family
B2J77_02985	COG1366	Belongs to the anti-sigma-factor antagonist family
B2J77_02990	COG2172	sigma factor antagonist activity
B2J77_03000	COG2205	protein histidine kinase activity
B2J77_03010	COG4774	siderophore transport
B2J77_03015	COG1074	ATP-dependent DNA helicase activity
B2J77_03020	COG0583	DNA-binding transcription factor activity
B2J77_03025	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
B2J77_03065	COG0165	Argininosuccinate lyase
B2J77_03115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B2J77_03150	COG3135	benzoate transporter
B2J77_03160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2J77_03165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2J77_03175	COG1304	FMN binding
B2J77_03180	COG1620	l-lactate permease
B2J77_03185	COG2186	Transcriptional regulator
B2J77_03190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B2J77_03200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2J77_03205	COG0735	belongs to the Fur family
B2J77_03210	COG0497	DNA recombination
B2J77_03215	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B2J77_03220	COG0443	Heat shock 70 kDa protein
B2J77_03225	COG0484	heat shock protein binding
B2J77_03230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B2J77_03235	COG0505	Belongs to the CarA family
B2J77_03240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B2J77_03245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2J77_03260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B2J77_03265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2J77_03270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B2J77_03275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2J77_03280	COG0149	triose-phosphate isomerase activity
B2J77_03285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B2J77_03300	COG0779	Required for maturation of 30S ribosomal subunits
B2J77_03305	COG0195	Participates in both transcription termination and antitermination
B2J77_03310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B2J77_03315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B2J77_03320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B2J77_03325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B2J77_03330	COG1185	polyribonucleotide nucleotidyltransferase activity
B2J77_03335	COG2823	Periplasmic or secreted lipoprotein
B2J77_03350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2J77_03355	COG0166	Belongs to the GPI family
B2J77_03360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B2J77_03365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B2J77_03375	COG0617	tRNA 3'-terminal CCA addition
B2J77_03385	COG4191	Histidine kinase
B2J77_03395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2J77_03400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B2J77_03410	COG1489	DNA binding
B2J77_03425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2J77_03430	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B2J77_03445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B2J77_03455	COG3098	single-species biofilm formation
B2J77_03460	COG0028	Belongs to the TPP enzyme family
B2J77_03470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B2J77_03475	COG1183	phosphatidylcholine synthase activity
B2J77_03480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B2J77_03485	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B2J77_03505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B2J77_03510	COG1074	ATP-dependent DNA helicase activity
B2J77_03515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B2J77_03540	COG4589	Belongs to the CDS family
B2J77_03555	COG2267	carboxylic ester hydrolase activity
B2J77_03560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B2J77_03565	COG0583	DNA-binding transcription factor activity
B2J77_03580	COG2249	NAD(P)H dehydrogenase (quinone) activity
B2J77_03585	COG0583	DNA-binding transcription factor activity
B2J77_03595	COG2801	Transposase and inactivated derivatives
B2J77_03600	COG2963	transposase activity
B2J77_03605	COG0840	transmembrane signaling receptor activity
B2J77_03610	COG2321	neutral zinc metallopeptidase
B2J77_03615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B2J77_03620	COG2252	PERMEase
B2J77_03630	COG1271	oxidase subunit
B2J77_03635	COG1294	oxidase, subunit
B2J77_03645	COG2813	Specifically methylates the guanine in position
B2J77_03660	COG1970	mechanosensitive ion channel activity
B2J77_03670	COG2233	PERMEase
B2J77_03685	COG1966	Carbon starvation protein
B2J77_03690	COG2879	small protein
B2J77_03695	COG0523	cobalamin synthesis protein
B2J77_03705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B2J77_03715	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B2J77_03745	COG1366	Belongs to the anti-sigma-factor antagonist family
B2J77_03765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B2J77_03790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2J77_03845	COG2207	Transcriptional regulator
B2J77_03845	COG3708	Transcriptional regulator
B2J77_03850	COG0697	spore germination
B2J77_03855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2J77_03860	COG0583	DNA-binding transcription factor activity
B2J77_03880	COG1566	PFAM secretion protein HlyD family protein
B2J77_03895	COG0477	Major facilitator Superfamily
B2J77_03910	COG0300	oxidoreductase activity
B2J77_03935	COG3022	response to hydroperoxide
B2J77_03945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B2J77_03950	COG0315	cyclic pyranopterin monophosphate synthase activity
B2J77_03955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B2J77_03965	COG0513	Belongs to the DEAD box helicase family
B2J77_03970	COG0400	carboxylic ester hydrolase activity
B2J77_03975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_03980	COG4597	amino acid ABC transporter
B2J77_03985	COG0765	amino acid transport
B2J77_03990	COG1126	abc transporter atp-binding protein
B2J77_03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2J77_04005	COG0175	sulfate reduction
B2J77_04020	COG1522	sequence-specific DNA binding
B2J77_04040	COG0180	Tryptophanyl-tRNA synthetase
B2J77_04045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B2J77_04055	COG0667	Aldo Keto reductase
B2J77_04060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B2J77_04065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B2J77_04070	COG0723	plastoquinol--plastocyanin reductase activity
B2J77_04075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B2J77_04080	COG2857	Cytochrome c1
B2J77_04085	COG0625	glutathione transferase activity
B2J77_04090	COG2969	positive regulation of protein catabolic process
B2J77_04095	COG2823	Periplasmic or secreted lipoprotein
B2J77_04100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B2J77_04105	COG0792	nuclease activity
B2J77_04110	COG3107	peptidoglycan biosynthetic process
B2J77_04125	COG2001	Belongs to the MraZ family
B2J77_04130	COG0275	rRNA processing
B2J77_04145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B2J77_04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B2J77_04155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2J77_04160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B2J77_04165	COG0772	Belongs to the SEDS family
B2J77_04170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B2J77_04175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B2J77_04180	COG1181	Belongs to the D-alanine--D-alanine ligase family
B2J77_04195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B2J77_04200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B2J77_04210	COG0653	protein targeting
B2J77_04215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B2J77_04220	COG0494	nUDIX hydrolase
B2J77_04225	COG2096	Adenosyltransferase
B2J77_04230	COG4191	Histidine kinase
B2J77_04230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_04240	COG1666	GTP binding
B2J77_04245	COG0668	transmembrane transport
B2J77_04260	COG3695	enzyme binding
B2J77_04280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B2J77_04285	COG0459	protein refolding
B2J77_04300	COG0642	Histidine kinase
B2J77_04350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B2J77_04360	COG0583	DNA-binding transcription factor activity
B2J77_04365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2J77_04375	COG1902	pentaerythritol trinitrate reductase activity
B2J77_04380	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
B2J77_04400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2J77_04405	COG0693	protein deglycase activity
B2J77_04420	COG3153	acetyltransferase
B2J77_04420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2J77_04435	COG0469	pyruvate kinase activity
B2J77_04450	COG2925	Exonuclease
B2J77_04460	COG0788	formyltetrahydrofolate deformylase activity
B2J77_04480	COG0438	transferase activity, transferring glycosyl groups
B2J77_04480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B2J77_04485	COG0840	transmembrane signaling receptor activity
B2J77_04490	COG0433	COG0433 Predicted ATPase
B2J77_04495	COG0306	phosphate transporter
B2J77_04510	COG1414	Transcriptional regulator
B2J77_04515	COG0183	Belongs to the thiolase family
B2J77_04520	COG0477	Major facilitator Superfamily
B2J77_04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_04545	COG1309	transcriptional regulator
B2J77_04550	COG0477	Major facilitator Superfamily
B2J77_04555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B2J77_04570	COG2207	Transcriptional regulator
B2J77_04595	COG0477	Major facilitator Superfamily
B2J77_04605	COG4191	Histidine kinase
B2J77_04655	COG0745	RESPONSE REGULATOR receiver
B2J77_04655	COG3706	GGDEF domain
B2J77_04670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B2J77_04720	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B2J77_04745	COG2801	Transposase and inactivated derivatives
B2J77_04775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2J77_04780	COG0481	GTPase activity
B2J77_04785	COG0681	Belongs to the peptidase S26 family
B2J77_04790	COG0571	ribonuclease III activity
B2J77_04795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B2J77_04800	COG1381	Involved in DNA repair and RecF pathway recombination
B2J77_04805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B2J77_04810	COG0500	methyltransferase
B2J77_04815	COG2226	methyltransferase
B2J77_04825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2J77_04840	COG4206	TonB-dependent receptor
B2J77_04845	COG4628	conserved protein (DUF2132)
B2J77_04855	COG2375	cellular response to nickel ion
B2J77_04860	COG1695	Transcriptional regulator
B2J77_04870	COG0069	glutamate synthase activity
B2J77_04875	COG1201	RNA secondary structure unwinding
B2J77_04880	COG0494	nUDIX hydrolase
B2J77_04885	COG0583	DNA-binding transcription factor activity
B2J77_04900	COG1126	abc transporter atp-binding protein
B2J77_04905	COG0765	amino acid transport
B2J77_04910	COG0765	amino acid transport
B2J77_04915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_04935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B2J77_04945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B2J77_04950	COG3842	ATPase activity
B2J77_04955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B2J77_04960	COG0243	molybdopterin cofactor binding
B2J77_04965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B2J77_04975	COG2906	2 iron, 2 sulfur cluster binding
B2J77_04980	COG0450	alkyl hydroperoxide reductase
B2J77_04985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2J77_04990	COG0418	dihydroorotase activity
B2J77_05000	COG0137	argininosuccinate synthase activity
B2J77_05010	COG2197	response regulator
B2J77_05020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B2J77_05025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2J77_05025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2J77_05030	COG0489	protein tyrosine kinase activity
B2J77_05035	COG1278	Cold shock
B2J77_05040	COG0717	Belongs to the dCTP deaminase family
B2J77_05055	COG1201	RNA secondary structure unwinding
B2J77_05065	COG1793	dna ligase
B2J77_05070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B2J77_05070	COG1793	dna ligase
B2J77_05075	COG2366	antibiotic biosynthetic process
B2J77_05080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_05085	COG2814	Major facilitator Superfamily
B2J77_05090	COG0653	protein targeting
B2J77_05100	COG3012	SEC-C Motif Domain Protein
B2J77_05130	COG1199	ATP-dependent helicase activity
B2J77_05145	COG2885	chlorophyll binding
B2J77_05150	COG0259	pyridoxamine-phosphate oxidase activity
B2J77_05165	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B2J77_05210	COG2084	Dehydrogenase
B2J77_05215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B2J77_05245	COG3706	GGDEF domain
B2J77_05250	COG2116	formate transmembrane transporter activity
B2J77_05285	COG3012	SEC-C Motif Domain Protein
B2J77_05285	COG3318	Belongs to the UPF0149 family
B2J77_05290	COG0625	glutathione transferase activity
B2J77_05415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B2J77_05420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B2J77_05420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B2J77_05430	COG0745	RESPONSE REGULATOR receiver
B2J77_05435	COG2205	protein histidine kinase activity
B2J77_05455	COG0745	RESPONSE REGULATOR receiver
B2J77_05465	COG1301	dicarboxylic acid transport
B2J77_05475	COG4807	Protein conserved in bacteria
B2J77_05490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B2J77_05495	COG3158	transport of potassium into the cell
B2J77_05525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B2J77_05535	COG0442	prolyl-tRNA aminoacylation
B2J77_05550	COG2900	Belongs to the SlyX family
B2J77_05560	COG0783	Belongs to the Dps family
B2J77_05575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B2J77_05580	COG0217	transcriptional regulatory protein
B2J77_05585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B2J77_05590	COG0632	four-way junction helicase activity
B2J77_05595	COG2255	four-way junction helicase activity
B2J77_05600	COG0824	Thioesterase
B2J77_05620	COG0823	Involved in the tonB-independent uptake of proteins
B2J77_05625	COG2885	chlorophyll binding
B2J77_05630	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B2J77_05635	COG0602	queuosine metabolic process
B2J77_05640	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B2J77_05665	COG2200	EAL domain
B2J77_05675	COG0531	amino acid
B2J77_05690	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B2J77_05695	COG4783	chaperone-mediated protein folding
B2J77_05700	COG0425	Belongs to the sulfur carrier protein TusA family
B2J77_05710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B2J77_05720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2J77_05725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B2J77_05730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B2J77_05735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B2J77_05785	COG0456	acetyltransferase
B2J77_05800	COG0579	oxidoreductase
B2J77_05805	COG0640	Transcriptional regulator
B2J77_05810	COG1902	pentaerythritol trinitrate reductase activity
B2J77_05815	COG0583	DNA-binding transcription factor activity
B2J77_05820	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2J77_05830	COG0776	regulation of translation
B2J77_05840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B2J77_05845	COG2755	lipolytic protein G-D-S-L family
B2J77_05845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B2J77_05855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2J77_05875	COG0438	transferase activity, transferring glycosyl groups
B2J77_05930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2J77_05940	COG1216	Glycosyl transferase, family 2
B2J77_05940	COG0438	transferase activity, transferring glycosyl groups
B2J77_05965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_05975	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B2J77_05985	COG0438	transferase activity, transferring glycosyl groups
B2J77_06000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2J77_06010	COG2963	transposase activity
B2J77_06015	COG2801	Transposase and inactivated derivatives
B2J77_06020	COG1555	photosystem II stabilization
B2J77_06030	COG0284	orotidine-5'-phosphate decarboxylase activity
B2J77_06035	COG2130	NADP-dependent
B2J77_06045	COG0840	transmembrane signaling receptor activity
B2J77_06050	COG3135	benzoate transporter
B2J77_06055	COG0625	glutathione transferase activity
B2J77_06065	COG0302	gtp cyclohydrolase
B2J77_06100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B2J77_06105	COG2814	Major facilitator Superfamily
B2J77_06110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B2J77_06140	COG1368	sulfuric ester hydrolase activity
B2J77_06160	COG0519	Catalyzes the synthesis of GMP from XMP
B2J77_06165	COG0598	Magnesium transport protein CorA
B2J77_06170	COG0204	Acyl-transferase
B2J77_06190	COG2814	Major facilitator Superfamily
B2J77_06195	COG0583	DNA-binding transcription factor activity
B2J77_06215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B2J77_06220	COG1846	Transcriptional regulator
B2J77_06225	COG0583	DNA-binding transcription factor activity
B2J77_06235	COG0583	DNA-binding transcription factor activity
B2J77_06245	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B2J77_06260	COG3384	dioxygenase
B2J77_06265	COG0500	methyltransferase
B2J77_06270	COG0501	Belongs to the peptidase M48B family
B2J77_06275	COG0436	Aminotransferase
B2J77_06280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2J77_06285	COG0386	Belongs to the glutathione peroxidase family
B2J77_06300	COG1956	GAF domain-containing protein
B2J77_06380	COG3539	Fimbrial protein
B2J77_06385	COG3121	Chaperone
B2J77_06405	COG1960	acyl-CoA dehydrogenase activity
B2J77_06410	COG0625	glutathione transferase activity
B2J77_06415	COG1131	(ABC) transporter
B2J77_06420	COG0842	Transport permease protein
B2J77_06440	COG0848	biopolymer transport protein
B2J77_06445	COG1663	tetraacyldisaccharide 4'-kinase activity
B2J77_06450	COG2835	tetraacyldisaccharide 4'-kinase activity
B2J77_06455	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B2J77_06460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B2J77_06465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B2J77_06470	COG1530	ribonuclease E activity
B2J77_06485	COG0546	phosphoglycolate phosphatase activity
B2J77_06490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B2J77_06490	COG0616	signal peptide processing
B2J77_06495	COG0424	maF-like protein
B2J77_06500	COG1399	metal-binding, possibly nucleic acid-binding protein
B2J77_06505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B2J77_06510	COG0416	fatty acid biosynthetic process
B2J77_06525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B2J77_06530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B2J77_06535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2J77_06540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B2J77_06545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B2J77_06555	COG0084	hydrolase, TatD family'
B2J77_06565	COG2801	Transposase and inactivated derivatives
B2J77_06615	COG0556	nucleotide-excision repair
B2J77_06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2J77_06660	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B2J77_06680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B2J77_06685	COG0066	3-isopropylmalate dehydratase activity
B2J77_06690	COG2226	methyltransferase
B2J77_06695	COG0473	3-isopropylmalate dehydrogenase activity
B2J77_06720	COG0135	phosphoribosylanthranilate isomerase activity
B2J77_06725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B2J77_06730	COG0285	dihydrofolate synthase activity
B2J77_06740	COG1286	toxin biosynthetic process
B2J77_06785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B2J77_06805	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2J77_06805	COG1902	pentaerythritol trinitrate reductase activity
B2J77_06815	COG3038	cytochrome b561
B2J77_06825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B2J77_06830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2J77_06840	COG3139	Protein of unknown function (DUF1315)
B2J77_06850	COG0308	aminopeptidase N
B2J77_06870	COG2706	6-phosphogluconolactonase activity
B2J77_06885	COG0420	3'-5' exonuclease activity
B2J77_06915	COG0714	Associated with various cellular activities
B2J77_06935	COG3237	CsbD-like
B2J77_06940	COG0789	Transcriptional regulator
B2J77_06945	COG2188	Transcriptional regulator
B2J77_06970	COG0019	diaminopimelate decarboxylase activity
B2J77_06975	COG0583	DNA-binding transcription factor activity
B2J77_06990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B2J77_07005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B2J77_07020	COG0668	transmembrane transport
B2J77_07035	COG0167	dihydroorotate dehydrogenase activity
B2J77_07040	COG3130	regulation of translation
B2J77_07045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B2J77_07045	COG0116	Belongs to the methyltransferase superfamily
B2J77_07050	COG2027	D-alanyl-D-alanine carboxypeptidase
B2J77_07055	COG3171	Protein conserved in bacteria
B2J77_07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_07060	COG2205	protein histidine kinase activity
B2J77_07065	COG2197	response regulator
B2J77_07090	COG0004	ammonium transporteR
B2J77_07115	COG0840	transmembrane signaling receptor activity
B2J77_07125	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B2J77_07140	COG0425	Belongs to the sulfur carrier protein TusA family
B2J77_07145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2J77_07155	COG1132	(ABC) transporter
B2J77_07170	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2J77_07180	COG1597	lipid kinase activity
B2J77_07185	COG2197	response regulator
B2J77_07190	COG3851	Histidine kinase
B2J77_07210	COG0741	lytic transglycosylase activity
B2J77_07220	COG0589	response to stress
B2J77_07230	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2J77_07230	COG1024	Enoyl-CoA hydratase
B2J77_07235	COG0183	Belongs to the thiolase family
B2J77_07265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B2J77_07280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B2J77_07290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B2J77_07300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2J77_07305	COG0584	glycerophosphoryl diester phosphodiesterase
B2J77_07315	COG4591	ABC-type transport system involved in lipoprotein release permease component
B2J77_07320	COG1136	(ABC) transporter
B2J77_07325	COG4591	ABC-type transport system involved in lipoprotein release permease component
B2J77_07345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B2J77_07345	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B2J77_07365	COG4566	intracellular signal transduction
B2J77_07390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2J77_07395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2J77_07410	COG0601	transmembrane transport
B2J77_07415	COG0747	negative chemotaxis
B2J77_07420	COG0235	Class ii aldolase
B2J77_07425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2J77_07430	COG1960	acyl-CoA dehydrogenase activity
B2J77_07435	COG0583	DNA-binding transcription factor activity
B2J77_07445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2J77_07450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B2J77_07455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B2J77_07465	COG1126	abc transporter atp-binding protein
B2J77_07475	COG0165	Argininosuccinate lyase
B2J77_07480	COG0765	amino acid transport
B2J77_07485	COG0765	amino acid transport
B2J77_07490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_07505	COG0745	RESPONSE REGULATOR receiver
B2J77_07515	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_07565	COG3383	formate dehydrogenase (NAD+) activity
B2J77_07575	COG0589	response to stress
B2J77_07615	COG2133	pyrroloquinoline quinone binding
B2J77_07620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B2J77_07625	COG0596	Alpha beta hydrolase
B2J77_07650	COG2207	Transcriptional regulator
B2J77_07660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2J77_07670	COG0183	Belongs to the thiolase family
B2J77_07675	COG1960	acyl-CoA dehydrogenase activity
B2J77_07680	COG1024	Enoyl-CoA hydratase
B2J77_07705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2J77_07715	COG4172	Belongs to the ABC transporter superfamily
B2J77_07720	COG4239	(ABC) transporter, permease
B2J77_07725	COG4174	ABC transporter (Permease)
B2J77_07730	COG4166	transmembrane transport
B2J77_07735	COG4166	transmembrane transport
B2J77_07740	COG0741	lytic transglycosylase activity
B2J77_07740	COG1388	LysM domain
B2J77_07745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B2J77_07755	COG0328	RNA-DNA hybrid ribonuclease activity
B2J77_07760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2J77_07770	COG0431	NADPH-dependent FMN reductase
B2J77_07805	COG1007	ATP synthesis coupled electron transport
B2J77_07820	COG0713	ATP synthesis coupled electron transport
B2J77_07830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2J77_07835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B2J77_07840	COG1034	ATP synthesis coupled electron transport
B2J77_07855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2J77_07855	COG0649	NAD binding
B2J77_07860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2J77_07865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2J77_07910	COG1404	Belongs to the peptidase S8 family
B2J77_07915	COG0659	secondary active sulfate transmembrane transporter activity
B2J77_07930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2J77_07935	COG1113	amino acid transport
B2J77_07960	COG0322	excinuclease ABC activity
B2J77_07980	COG2066	Belongs to the glutaminase family
B2J77_07990	COG0583	DNA-binding transcription factor activity
B2J77_07995	COG2828	Protein conserved in bacteria
B2J77_08000	COG1301	dicarboxylic acid transport
B2J77_08005	COG2851	Citrate transporter
B2J77_08035	COG1024	Enoyl-CoA hydratase
B2J77_08040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B2J77_08045	COG1960	acyl-CoA dehydrogenase activity
B2J77_08050	COG0318	PFAM AMP-dependent synthetase and ligase
B2J77_08065	COG0366	Alpha amylase catalytic
B2J77_08070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B2J77_08090	COG1640	4-alpha-glucanotransferase
B2J77_08100	COG0297	glycogen (starch) synthase activity
B2J77_08105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B2J77_08110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B2J77_08115	COG3387	PFAM Glycoside hydrolase 15-related
B2J77_08120	COG1309	transcriptional regulator
B2J77_08130	COG0493	'glutamate synthase
B2J77_08140	COG1953	Uracil, thiamine, allantoin
B2J77_08150	COG1234	tRNA 3'-trailer cleavage
B2J77_08155	COG3040	lipid binding
B2J77_08160	COG1024	Enoyl-CoA hydratase
B2J77_08165	COG2816	NAD+ diphosphatase activity
B2J77_08175	COG0174	glutamine synthetase
B2J77_08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B2J77_08185	COG2153	protein acetylation
B2J77_08190	COG2850	peptidyl-arginine hydroxylation
B2J77_08200	COG2915	High frequency lysogenization protein hflD homolog
B2J77_08205	COG0482	sulfurtransferase activity
B2J77_08220	COG1278	Cold shock
B2J77_08225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B2J77_08230	COG0542	response to heat
B2J77_08235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B2J77_08240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B2J77_08245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B2J77_08250	COG1674	ftsk spoiiie
B2J77_08255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B2J77_08260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B2J77_08265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B2J77_08270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B2J77_08275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B2J77_08275	COG1648	precorrin-2 dehydrogenase activity
B2J77_08305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B2J77_08315	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_08320	COG0583	DNA-binding transcription factor activity
B2J77_08325	COG3284	Transcriptional regulator
B2J77_08335	COG0435	Glutathione S-transferase
B2J77_08340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B2J77_08345	COG2920	part of a sulfur-relay system
B2J77_08365	COG2233	PERMEase
B2J77_08410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B2J77_08440	COG1309	transcriptional regulator
B2J77_08445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2J77_08445	COG2010	Cytochrome c
B2J77_08450	COG2080	2 iron, 2 sulfur cluster binding
B2J77_08455	COG1846	Transcriptional regulator
B2J77_08460	COG2309	aminopeptidase activity
B2J77_08465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2J77_08470	COG0596	Alpha beta hydrolase
B2J77_08475	COG3473	Maleate cis-trans isomerase
B2J77_08480	COG1335	isochorismatase
B2J77_08485	COG2271	Major facilitator Superfamily
B2J77_08500	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B2J77_08520	COG2199	diguanylate cyclase activity
B2J77_08525	COG0490	domain, Protein
B2J77_08525	COG0471	metal ion transport
B2J77_08540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B2J77_08545	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_08565	COG0616	signal peptide processing
B2J77_08585	COG5383	Protein conserved in bacteria
B2J77_08590	COG2814	Major facilitator Superfamily
B2J77_08600	COG2135	peptidase activity
B2J77_08615	COG3642	lipopolysaccharide core region biosynthetic process
B2J77_08665	COG1064	alcohol dehydrogenase
B2J77_08680	COG4191	Histidine kinase
B2J77_08680	COG0784	Response regulator, receiver
B2J77_08685	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B2J77_08690	COG0745	RESPONSE REGULATOR receiver
B2J77_08695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B2J77_08705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B2J77_08740	COG2863	cytochrome
B2J77_08745	COG3258	Cytochrome c
B2J77_08760	COG0450	alkyl hydroperoxide reductase
B2J77_08765	COG3634	alkyl hydroperoxide reductase activity
B2J77_08775	COG3132	Protein of unknown function, DUF480
B2J77_08780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B2J77_08785	COG0583	DNA-binding transcription factor activity
B2J77_08795	COG1253	flavin adenine dinucleotide binding
B2J77_08810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_08840	COG4772	TonB-dependent receptor
B2J77_08845	COG0252	asparaginase activity
B2J77_08850	COG1879	ABC-type sugar transport system periplasmic component
B2J77_08855	COG1129	ABC transporter
B2J77_08860	COG1172	Belongs to the binding-protein-dependent transport system permease family
B2J77_08865	COG1609	Transcriptional regulator
B2J77_08870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2J77_08875	COG1869	D-ribose catabolic process
B2J77_08895	COG1278	Cold shock
B2J77_08905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B2J77_08910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B2J77_08915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B2J77_08920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B2J77_08925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B2J77_08930	COG0072	phenylalanine-tRNA ligase activity
B2J77_08935	COG0776	regulation of translation
B2J77_09035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2J77_09065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B2J77_09260	COG3617	BRO family, N-terminal domain
B2J77_09340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_09345	COG1126	abc transporter atp-binding protein
B2J77_09350	COG0765	amino acid transport
B2J77_09355	COG0765	amino acid transport
B2J77_09370	COG2814	Major facilitator Superfamily
B2J77_09385	COG2186	Transcriptional regulator
B2J77_09405	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_09430	COG0667	Aldo Keto reductase
B2J77_09475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2J77_09480	COG0590	tRNA wobble adenosine to inosine editing
B2J77_09485	COG2807	transmembrane transport
B2J77_09500	COG0247	lactate metabolic process
B2J77_09505	COG0277	FAD linked oxidase domain protein
B2J77_09525	COG0768	penicillin binding
B2J77_09555	COG2801	Transposase and inactivated derivatives
B2J77_09565	COG0210	DNA helicase
B2J77_09570	COG0596	Alpha beta hydrolase
B2J77_09580	COG0346	lactoylglutathione lyase activity
B2J77_09590	COG0456	acetyltransferase
B2J77_09605	COG0583	DNA-binding transcription factor activity
B2J77_09635	COG1304	FMN binding
B2J77_09645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_09655	COG4106	trans-aconitate 2-methyltransferase activity
B2J77_09660	COG0217	transcriptional regulatory protein
B2J77_09665	COG0583	DNA-binding transcription factor activity
B2J77_09670	COG0076	glutamate decarboxylase activity
B2J77_09690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2J77_09695	COG5001	Diguanylate cyclase
B2J77_09695	COG3300	MHYT domain
B2J77_09700	COG5001	Diguanylate cyclase
B2J77_09700	COG3300	MHYT domain
B2J77_09705	COG1611	Belongs to the LOG family
B2J77_09710	COG2855	membrane
B2J77_09740	COG4191	Histidine kinase
B2J77_09740	COG0784	Response regulator, receiver
B2J77_09745	COG0784	Response regulator, receiver
B2J77_09745	COG4191	Histidine kinase
B2J77_09755	COG2186	Transcriptional regulator
B2J77_09760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2J77_09770	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_09775	COG2267	carboxylic ester hydrolase activity
B2J77_09785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2J77_09790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2J77_09795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B2J77_09820	COG1116	anion transmembrane transporter activity
B2J77_09825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2J77_09830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2J77_09840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2J77_09845	COG0583	DNA-binding transcription factor activity
B2J77_09850	COG4991	sh3 domain protein
B2J77_09860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2J77_09890	COG1944	ATP diphosphatase activity
B2J77_09915	COG2391	methyltransferase activity
B2J77_09930	COG2186	Transcriptional regulator
B2J77_09935	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_09940	COG2721	sulfolactate sulfo-lyase activity
B2J77_09945	COG2271	Major facilitator Superfamily
B2J77_09950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2J77_09955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B2J77_09965	COG1448	Aminotransferase
B2J77_09970	COG0814	amino acid
B2J77_09995	COG1538	Outer membrane efflux protein
B2J77_10020	COG1595	DNA-templated transcription, initiation
B2J77_10025	COG3712	iron ion homeostasis
B2J77_10045	COG4176	ABC-type proline glycine betaine transport system permease component
B2J77_10055	COG0840	transmembrane signaling receptor activity
B2J77_10060	COG2056	Na+-H+ antiporter family
B2J77_10070	COG1846	Transcriptional regulator
B2J77_10075	COG1566	PFAM secretion protein HlyD family protein
B2J77_10080	COG2814	Major facilitator Superfamily
B2J77_10085	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_10095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_10100	COG0348	domain, Protein
B2J77_10110	COG1285	pathogenesis
B2J77_10120	COG0789	Transcriptional regulator
B2J77_10125	COG0405	Gamma-glutamyltransferase
B2J77_10130	COG0583	DNA-binding transcription factor activity
B2J77_10140	COG3257	ureidoglycine aminohydrolase activity
B2J77_10150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2J77_10185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2J77_10190	COG0488	(ABC) transporter
B2J77_10220	COG2204	response regulator
B2J77_10225	COG0826	peptidase U32
B2J77_10235	COG2384	SAM-dependent methyltransferase
B2J77_10245	COG1960	acyl-CoA dehydrogenase activity
B2J77_10280	COG0477	Major facilitator Superfamily
B2J77_10290	COG0307	riboflavin synthase, alpha
B2J77_10315	COG0019	diaminopimelate decarboxylase activity
B2J77_10335	COG0154	amidase activity
B2J77_10340	COG0625	glutathione transferase activity
B2J77_10350	COG0488	(ABC) transporter
B2J77_10370	COG0431	NADPH-dependent FMN reductase
B2J77_10375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B2J77_10385	COG0640	Transcriptional regulator
B2J77_10405	COG0456	acetyltransferase
B2J77_10475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2J77_10490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2J77_10515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2J77_10520	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_10525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2J77_10530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2J77_10545	COG2814	Major facilitator Superfamily
B2J77_10550	COG2801	Transposase and inactivated derivatives
B2J77_10575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_10580	COG0745	RESPONSE REGULATOR receiver
B2J77_10585	COG2205	protein histidine kinase activity
B2J77_10595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2J77_10635	COG1253	flavin adenine dinucleotide binding
B2J77_10645	COG2200	EAL domain
B2J77_10665	COG4191	Histidine kinase
B2J77_10665	COG0784	Response regulator, receiver
B2J77_10685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_10700	COG3265	gluconokinase activity
B2J77_10710	COG2205	protein histidine kinase activity
B2J77_10710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_10715	COG2197	response regulator
B2J77_10720	COG3813	Protein conserved in bacteria
B2J77_10795	COG1609	Transcriptional regulator
B2J77_10805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2J77_10810	COG2271	Major facilitator Superfamily
B2J77_10820	COG2356	endonuclease I
B2J77_10825	COG0667	Aldo Keto reductase
B2J77_10835	COG2814	Major facilitator Superfamily
B2J77_10850	COG4251	negative regulation of phosphorylation
B2J77_10855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B2J77_10870	COG2323	membrane
B2J77_10910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2J77_10915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B2J77_10950	COG4106	trans-aconitate 2-methyltransferase activity
B2J77_11005	COG0494	nUDIX hydrolase
B2J77_11020	COG3568	Endonuclease Exonuclease Phosphatase
B2J77_11030	COG0392	lysyltransferase activity
B2J77_11055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B2J77_11080	COG2890	protein-(glutamine-N5) methyltransferase activity
B2J77_11125	COG3706	GGDEF domain
B2J77_11155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2J77_11160	COG2423	ornithine cyclodeaminase activity
B2J77_11165	COG0402	S-adenosylhomocysteine deaminase activity
B2J77_11170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B2J77_11190	COG1929	Belongs to the glycerate kinase type-1 family
B2J77_11195	COG3835	regulator
B2J77_11200	COG2271	Major facilitator Superfamily
B2J77_11205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B2J77_11210	COG3284	Transcriptional regulator
B2J77_11215	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_11250	COG2197	response regulator
B2J77_11255	COG1136	(ABC) transporter
B2J77_11255	COG0577	efflux transmembrane transporter activity
B2J77_11260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_11295	COG0583	DNA-binding transcription factor activity
B2J77_11300	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_11305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B2J77_11315	COG0174	glutamine synthetase
B2J77_11325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_11335	COG1760	l-serine dehydratase
B2J77_11340	COG0583	DNA-binding transcription factor activity
B2J77_11375	COG1045	serine acetyltransferase
B2J77_11415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B2J77_11445	COG2031	fatty acid transporter
B2J77_11455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B2J77_11465	COG0656	L-ascorbic acid biosynthetic process
B2J77_11470	COG0587	DNA-directed DNA polymerase activity
B2J77_11485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B2J77_11490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2J77_11520	COG2801	Transposase and inactivated derivatives
B2J77_11535	COG0215	cysteine-tRNA ligase activity
B2J77_11540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2J77_11550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2J77_11555	COG2366	antibiotic biosynthetic process
B2J77_11595	COG0729	surface antigen
B2J77_11605	COG0708	Exodeoxyribonuclease III
B2J77_11615	COG1595	DNA-templated transcription, initiation
B2J77_11620	COG0753	catalase activity
B2J77_11625	COG3038	cytochrome b561
B2J77_11630	COG1917	Cupin 2, conserved barrel domain protein
B2J77_11630	COG1396	sequence-specific DNA binding
B2J77_11660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B2J77_11675	COG1968	undecaprenyl-diphosphatase activity
B2J77_11680	COG0840	transmembrane signaling receptor activity
B2J77_11730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B2J77_11735	COG0830	nickel cation binding
B2J77_11745	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B2J77_11750	COG0804	urea catabolic process
B2J77_11755	COG0832	Belongs to the urease beta subunit family
B2J77_11760	COG0831	urea catabolic process
B2J77_11765	COG0829	nickel cation binding
B2J77_11770	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B2J77_11775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2J77_11775	COG1199	ATP-dependent helicase activity
B2J77_11785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_11835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B2J77_11840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B2J77_11845	COG1845	cytochrome c oxidase, subunit III
B2J77_11855	COG2814	Major facilitator Superfamily
B2J77_11860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B2J77_11865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2J77_11905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B2J77_11910	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_11940	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_11965	COG2010	Cytochrome c
B2J77_11965	COG4993	Dehydrogenase
B2J77_11985	COG4585	Histidine kinase
B2J77_12000	COG1131	(ABC) transporter
B2J77_12020	COG2205	protein histidine kinase activity
B2J77_12020	COG0784	Response regulator, receiver
B2J77_12045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B2J77_12050	COG0581	inorganic phosphate transmembrane transporter activity
B2J77_12060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B2J77_12090	COG0784	Response regulator, receiver
B2J77_12090	COG4191	Histidine kinase
B2J77_12095	COG0596	Alpha beta hydrolase
B2J77_12100	COG2205	protein histidine kinase activity
B2J77_12105	COG1063	alcohol dehydrogenase
B2J77_12110	COG0784	Response regulator, receiver
B2J77_12110	COG4191	Histidine kinase
B2J77_12140	COG3387	PFAM Glycoside hydrolase 15-related
B2J77_12150	COG0673	inositol 2-dehydrogenase activity
B2J77_12180	COG0668	transmembrane transport
B2J77_12185	COG3546	catalase activity
B2J77_12200	COG0477	Major facilitator Superfamily
B2J77_12210	COG0028	Belongs to the TPP enzyme family
B2J77_12215	COG2080	2 iron, 2 sulfur cluster binding
B2J77_12220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B2J77_12225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2J77_12250	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_12255	COG0583	DNA-binding transcription factor activity
B2J77_12260	COG1132	(ABC) transporter
B2J77_12285	COG2814	Major facilitator Superfamily
B2J77_12290	COG0583	DNA-binding transcription factor activity
B2J77_12295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B2J77_12300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_12305	COG0697	spore germination
B2J77_12310	COG2205	protein histidine kinase activity
B2J77_12310	COG2198	Histidine kinase
B2J77_12310	COG0784	Response regulator, receiver
B2J77_12310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_12315	COG2205	protein histidine kinase activity
B2J77_12315	COG0784	Response regulator, receiver
B2J77_12325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B2J77_12355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B2J77_12365	COG0784	Response regulator, receiver
B2J77_12365	COG2205	protein histidine kinase activity
B2J77_12365	COG5002	protein histidine kinase activity
B2J77_12380	COG1686	Belongs to the peptidase S11 family
B2J77_12420	COG1121	(ABC) transporter
B2J77_12460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B2J77_12470	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2J77_12475	COG1177	transmembrane transport
B2J77_12480	COG3842	ATPase activity
B2J77_12485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B2J77_12490	COG0861	Integral membrane protein TerC family
B2J77_12520	COG1104	cysteine desulfurase activity
B2J77_12530	COG0583	DNA-binding transcription factor activity
B2J77_12545	COG2814	Major facilitator Superfamily
B2J77_12555	COG1064	alcohol dehydrogenase
B2J77_12560	COG2207	Transcriptional regulator
B2J77_12590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2J77_12595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B2J77_12615	COG3706	GGDEF domain
B2J77_12620	COG0477	Major facilitator Superfamily
B2J77_12635	COG0417	DNA replication proofreading
B2J77_12640	COG0583	DNA-binding transcription factor activity
B2J77_12675	COG2207	Transcriptional regulator
B2J77_12690	COG1999	signal sequence binding
B2J77_12695	COG0316	Belongs to the HesB IscA family
B2J77_12695	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B2J77_12700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B2J77_12715	COG1879	ABC-type sugar transport system periplasmic component
B2J77_12735	COG2866	Carboxypeptidase
B2J77_12775	COG4251	negative regulation of phosphorylation
B2J77_12780	COG0745	RESPONSE REGULATOR receiver
B2J77_12800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B2J77_12825	COG0745	RESPONSE REGULATOR receiver
B2J77_12845	COG0720	synthase
B2J77_12875	COG2828	Protein conserved in bacteria
B2J77_12885	COG0372	Belongs to the citrate synthase family
B2J77_12895	COG1802	Transcriptional regulator
B2J77_12900	COG0189	ligase activity
B2J77_12900	COG4067	protein conserved in archaea
B2J77_12930	COG0589	response to stress
B2J77_12935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B2J77_12940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2J77_12955	COG1388	LysM domain
B2J77_12955	COG1376	ErfK ybiS ycfS ynhG family protein
B2J77_12970	COG4181	ATPase activity
B2J77_12975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B2J77_12980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2J77_12995	COG4175	Glycine betaine
B2J77_12995	COG0517	IMP dehydrogenase activity
B2J77_13000	COG1414	Transcriptional regulator
B2J77_13010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2J77_13015	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B2J77_13035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2J77_13045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B2J77_13050	COG0084	hydrolase, TatD family'
B2J77_13085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2J77_13095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2J77_13100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B2J77_13105	COG0740	serine-type endopeptidase activity
B2J77_13110	COG0544	peptidyl-prolyl cis-trans isomerase activity
B2J77_13140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B2J77_13170	COG0840	transmembrane signaling receptor activity
B2J77_13175	COG0730	response to heat
B2J77_13235	COG1335	isochorismatase
B2J77_13250	COG2111	Na H antiporter
B2J77_13250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B2J77_13255	COG1006	Multisubunit Na H antiporter MnhC subunit
B2J77_13260	COG0651	ATP synthesis coupled electron transport
B2J77_13270	COG2212	antiporter activity
B2J77_13275	COG1320	monovalent cation:proton antiporter activity
B2J77_13290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B2J77_13320	COG0745	RESPONSE REGULATOR receiver
B2J77_13325	COG2205	protein histidine kinase activity
B2J77_13330	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B2J77_13340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B2J77_13350	COG0628	permease
B2J77_13360	COG0596	Alpha beta hydrolase
B2J77_13375	COG2062	phosphohistidine phosphatase, SixA
B2J77_13385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B2J77_13400	COG4999	Histidine kinase
B2J77_13400	COG3850	Histidine kinase
B2J77_13400	COG3437	response regulator, receiver
B2J77_13400	COG2205	protein histidine kinase activity
B2J77_13405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B2J77_13425	COG0326	Molecular chaperone. Has ATPase activity
B2J77_13450	COG0045	succinate-CoA ligase (ADP-forming) activity
B2J77_13455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2J77_13470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B2J77_13475	COG1053	succinate dehydrogenase
B2J77_13480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B2J77_13485	COG2009	succinate dehydrogenase
B2J77_13510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_13515	COG3047	cAMP biosynthetic process
B2J77_13515	COG2885	chlorophyll binding
B2J77_13560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_13565	COG0577	efflux transmembrane transporter activity
B2J77_13565	COG1136	(ABC) transporter
B2J77_13570	COG1538	Outer membrane efflux protein
B2J77_13645	COG2801	Transposase and inactivated derivatives
B2J77_13650	COG0642	Histidine kinase
B2J77_13655	COG0745	RESPONSE REGULATOR receiver
B2J77_13660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B2J77_13690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B2J77_13715	COG3436	PFAM IS66 Orf2 family protein
B2J77_13730	COG1131	(ABC) transporter
B2J77_13760	COG3123	guanosine phosphorylase activity
B2J77_13770	COG3278	Belongs to the heme-copper respiratory oxidase family
B2J77_13785	COG2010	Cytochrome c
B2J77_13795	COG3278	Belongs to the heme-copper respiratory oxidase family
B2J77_13810	COG2010	Cytochrome c
B2J77_13815	COG0348	domain, Protein
B2J77_13825	COG2217	Heavy metal translocating P-type atpase
B2J77_13845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B2J77_13850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B2J77_13855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B2J77_13860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B2J77_13865	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B2J77_13890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B2J77_13895	COG3115	cell septum assembly
B2J77_13915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2J77_13925	COG0402	S-adenosylhomocysteine deaminase activity
B2J77_13935	COG2252	PERMEase
B2J77_13960	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B2J77_13970	COG2233	PERMEase
B2J77_13975	COG3248	Nucleoside-binding outer membrane protein
B2J77_13985	COG2354	Protein conserved in bacteria
B2J77_13990	COG0028	Belongs to the TPP enzyme family
B2J77_14005	COG3960	tartronate-semialdehyde synthase activity
B2J77_14010	COG3622	Belongs to the hyi family
B2J77_14015	COG2084	Dehydrogenase
B2J77_14025	COG0469	pyruvate kinase activity
B2J77_14030	COG4413	Urea transporter
B2J77_14035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B2J77_14050	COG1953	Uracil, thiamine, allantoin
B2J77_14080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2J77_14105	COG1138	Cytochrome C-type biogenesis protein
B2J77_14110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B2J77_14130	COG4133	protoheme IX ABC transporter activity
B2J77_14140	COG2257	FlhB HrpN YscU SpaS Family
B2J77_14155	COG0835	chemotaxis
B2J77_14165	COG1192	Involved in chromosome partitioning
B2J77_14170	COG1360	Flagellar Motor Protein
B2J77_14175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B2J77_14180	COG2201	protein-glutamate methylesterase activity
B2J77_14185	COG0643	Histidine kinase
B2J77_14185	COG2198	Histidine kinase
B2J77_14190	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B2J77_14205	COG0455	bacterial-type flagellum organization
B2J77_14215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B2J77_14230	COG1987	bacterial-type flagellum assembly
B2J77_14270	COG0745	RESPONSE REGULATOR receiver
B2J77_14280	COG2882	bacterial-type flagellum organization
B2J77_14305	COG1677	Flagellar hook-basal body complex protein FliE
B2J77_14310	COG2204	response regulator
B2J77_14315	COG4191	Histidine kinase
B2J77_14320	COG2204	response regulator
B2J77_14340	COG1334	flagellar protein FlaG
B2J77_14350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2J77_14360	COG1256	bacterial-type flagellum assembly
B2J77_14360	COG4786	Flagellar basal body rod
B2J77_14370	COG1706	bacterial-type flagellum-dependent cell motility
B2J77_14375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B2J77_14380	COG4786	Flagellar basal body rod
B2J77_14385	COG4787	bacterial-type flagellum-dependent cell motility
B2J77_14395	COG1749	Flagellar hook protein flgE
B2J77_14400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B2J77_14405	COG1558	bacterial-type flagellum-dependent cell motility
B2J77_14410	COG1815	bacterial-type flagellum-dependent cell motility
B2J77_14415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B2J77_14420	COG0835	chemotaxis
B2J77_14420	COG0784	Response regulator, receiver
B2J77_14440	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B2J77_14450	COG0477	Major facilitator Superfamily
B2J77_14455	COG1522	sequence-specific DNA binding
B2J77_14460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B2J77_14465	COG0022	dehydrogenase e1 component
B2J77_14475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2J77_14480	COG3706	GGDEF domain
B2J77_14490	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B2J77_14500	COG2239	Acts as a magnesium transporter
B2J77_14525	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B2J77_14530	COG0527	aspartate kinase activity
B2J77_14535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B2J77_14550	COG2988	succinylglutamate desuccinylase activity
B2J77_14560	COG3724	N-succinylarginine dihydrolase activity
B2J77_14565	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_14580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2J77_14600	COG4215	(ABC) transporter
B2J77_14605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_14610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2J77_14620	COG3283	Transcriptional regulator of aromatic amino acids metabolism
B2J77_14630	COG2154	pterin-4-alpha-carbinolamine dehydratase
B2J77_14640	COG0247	lactate metabolic process
B2J77_14640	COG0277	FAD linked oxidase domain protein
B2J77_14650	COG1113	amino acid transport
B2J77_14660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B2J77_14665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B2J77_14670	COG0009	L-threonylcarbamoyladenylate synthase
B2J77_14675	COG0613	PHP domain protein
B2J77_14680	COG2917	probably involved in intracellular septation
B2J77_14685	COG2350	Protein conserved in bacteria
B2J77_14690	COG0745	RESPONSE REGULATOR receiver
B2J77_14705	COG0778	Nitroreductase
B2J77_14710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B2J77_14735	COG0514	ATP-dependent DNA helicase (RecQ)
B2J77_14750	COG2832	Protein of unknown function (DUF454)
B2J77_14765	COG0840	transmembrane signaling receptor activity
B2J77_14770	COG0697	spore germination
B2J77_14785	COG0513	Belongs to the DEAD box helicase family
B2J77_14790	COG0668	transmembrane transport
B2J77_14800	COG0679	Auxin Efflux Carrier
B2J77_14815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B2J77_14820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B2J77_14830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B2J77_14845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B2J77_14850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B2J77_14855	COG0546	phosphoglycolate phosphatase activity
B2J77_14860	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_14870	COG5002	protein histidine kinase activity
B2J77_14870	COG5001	Diguanylate cyclase
B2J77_14885	COG2851	Citrate transporter
B2J77_14890	COG0583	DNA-binding transcription factor activity
B2J77_14910	COG0271	Belongs to the BolA IbaG family
B2J77_14920	COG0114	fumarate hydratase activity
B2J77_14925	COG0697	spore germination
B2J77_14930	COG2326	polyphosphate kinase activity
B2J77_14935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_14935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B2J77_14950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2J77_14960	COG1120	ATPase activity
B2J77_14965	COG4774	siderophore transport
B2J77_14975	COG0367	asparagine synthase
B2J77_14985	COG1363	Peptidase, m42
B2J77_14990	COG3089	Belongs to the UPF0270 family
B2J77_15010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2J77_15015	COG3162	membrane
B2J77_15025	COG2801	Transposase and inactivated derivatives
B2J77_15045	COG0174	glutamine synthetase
B2J77_15050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_15055	COG0318	PFAM AMP-dependent synthetase and ligase
B2J77_15060	COG0318	PFAM AMP-dependent synthetase and ligase
B2J77_15065	COG2030	dehydratase
B2J77_15075	COG1295	ribonuclease BN
B2J77_15115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B2J77_15125	COG3604	Transcriptional regulator
B2J77_15135	COG1984	allophanate hydrolase subunit 2
B2J77_15140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B2J77_15145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B2J77_15155	COG0583	DNA-binding transcription factor activity
B2J77_15165	COG0121	glutamine amidotransferase
B2J77_15185	COG1403	HNH endonuclease
B2J77_15205	COG2983	Belongs to the UPF0260 family
B2J77_15210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2J77_15215	COG3100	YcgL domain-containing protein
B2J77_15235	COG0626	cystathionine gamma-synthase activity
B2J77_15240	COG1522	sequence-specific DNA binding
B2J77_15250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B2J77_15255	COG3781	membrane
B2J77_15260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B2J77_15280	COG1132	(ABC) transporter
B2J77_15295	COG2188	Transcriptional regulator
B2J77_15305	COG1643	Atp-dependent helicase
B2J77_15310	COG2113	Glycine betaine
B2J77_15330	COG2853	Lipoprotein
B2J77_15335	COG1560	Kdo2-lipid A biosynthetic process
B2J77_15340	COG0850	regulation of cytokinetic process
B2J77_15345	COG2894	cell division
B2J77_15350	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B2J77_15355	COG0564	pseudouridine synthase activity
B2J77_15360	COG1362	aminopeptidase activity
B2J77_15370	COG0668	transmembrane transport
B2J77_15385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B2J77_15390	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2J77_15430	COG3339	Conserved Protein
B2J77_15440	COG0024	Methionine aminopeptidase
B2J77_15465	COG2974	May be involved in recombination
B2J77_15470	COG0385	Bile acid
B2J77_15475	COG2076	Multidrug Resistance protein
B2J77_15485	COG3618	amidohydrolase
B2J77_15495	COG2188	Transcriptional regulator
B2J77_15500	COG2205	protein histidine kinase activity
B2J77_15530	COG0583	DNA-binding transcription factor activity
B2J77_15580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B2J77_15590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B2J77_15600	COG1492	cobalamin metabolic process
B2J77_15615	COG0778	Nitroreductase
B2J77_15620	COG1797	cobyrinic acid a,c-diamide synthase activity
B2J77_15635	COG0791	NLP P60 protein
B2J77_15645	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B2J77_15650	COG0628	permease
B2J77_15660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B2J77_15665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B2J77_15680	COG3122	Protein conserved in bacteria
B2J77_15685	COG3956	TIGRFAM MazG family protein
B2J77_15690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2J77_15695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B2J77_15705	COG5002	protein histidine kinase activity
B2J77_15705	COG2205	protein histidine kinase activity
B2J77_15705	COG0784	Response regulator, receiver
B2J77_15710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2J77_15730	COG1393	Belongs to the ArsC family
B2J77_15750	COG0037	tRNA processing
B2J77_15755	COG3091	SprT-like family
B2J77_15765	COG0583	DNA-binding transcription factor activity
B2J77_15795	COG2137	regulation of response to DNA damage stimulus
B2J77_15800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B2J77_15805	COG1546	Belongs to the CinA family
B2J77_15810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B2J77_15815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B2J77_15830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B2J77_15835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B2J77_15840	COG0585	pseudouridine synthase activity
B2J77_15845	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B2J77_15855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B2J77_15865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B2J77_15875	COG0148	phosphopyruvate hydratase activity
B2J77_15880	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B2J77_15885	COG0504	CTP synthase activity
B2J77_15895	COG0037	tRNA processing
B2J77_15900	COG0825	malonyl-CoA metabolic process
B2J77_15910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B2J77_15915	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2J77_15920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2J77_15925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B2J77_15930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2J77_15950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B2J77_15960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B2J77_15965	COG0233	cytoplasmic translational termination
B2J77_15970	COG0528	UMP kinase activity
B2J77_15975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B2J77_15980	COG0052	Belongs to the universal ribosomal protein uS2 family
B2J77_15985	COG0024	Methionine aminopeptidase
B2J77_15990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B2J77_15995	COG0436	Aminotransferase
B2J77_16000	COG0025	NhaP-type Na H and K H
B2J77_16005	COG1393	Belongs to the ArsC family
B2J77_16010	COG2171	N-acyltransferase activity
B2J77_16015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B2J77_16025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B2J77_16030	COG1215	transferase activity, transferring glycosyl groups
B2J77_16035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2J77_16040	COG2226	methyltransferase
B2J77_16055	COG2937	Belongs to the GPAT DAPAT family
B2J77_16085	COG0742	ribosomal rna small subunit methyltransferase
B2J77_16105	COG1801	Protein of unknown function DUF72
B2J77_16120	COG0563	adenylate kinase activity
B2J77_16125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B2J77_16140	COG2885	chlorophyll binding
B2J77_16150	COG1073	alpha beta
B2J77_16170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B2J77_16180	COG5001	Diguanylate cyclase
B2J77_16180	COG3706	GGDEF domain
B2J77_16180	COG2203	Gaf domain
B2J77_16180	COG4251	negative regulation of phosphorylation
B2J77_16185	COG2201	protein-glutamate methylesterase activity
B2J77_16200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B2J77_16200	COG0457	Tetratricopeptide repeat
B2J77_16220	COG1902	pentaerythritol trinitrate reductase activity
B2J77_16230	COG4681	YaeQ
B2J77_16235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2J77_16270	COG4974	Belongs to the 'phage' integrase family
B2J77_16275	COG1607	acyl-coa hydrolase
B2J77_16280	COG0335	large ribosomal subunit rRNA binding
B2J77_16285	COG0336	Belongs to the RNA methyltransferase TrmD family
B2J77_16290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B2J77_16295	COG0228	four-way junction DNA binding
B2J77_16300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B2J77_16310	COG4536	flavin adenine dinucleotide binding
B2J77_16315	COG0477	Major facilitator Superfamily
B2J77_16320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B2J77_16350	COG3034	peptidoglycan biosynthetic process
B2J77_16395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B2J77_16395	COG0047	phosphoribosylformylglycinamidine synthase activity
B2J77_16400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B2J77_16405	COG0590	tRNA wobble adenosine to inosine editing
B2J77_16445	COG0583	DNA-binding transcription factor activity
B2J77_16450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2J77_16460	COG0583	DNA-binding transcription factor activity
B2J77_16465	COG0402	S-adenosylhomocysteine deaminase activity
B2J77_16475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B2J77_16475	COG0519	Catalyzes the synthesis of GMP from XMP
B2J77_16500	COG1570	exodeoxyribonuclease VII activity
B2J77_16505	COG0739	heme binding
B2J77_16515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2J77_16520	COG0800	Aldolase
B2J77_16535	COG1737	Transcriptional regulator
B2J77_16540	COG0676	glucose-6-phosphate 1-epimerase activity
B2J77_16550	COG3842	ATPase activity
B2J77_16575	COG2205	protein histidine kinase activity
B2J77_16580	COG0745	RESPONSE REGULATOR receiver
B2J77_16600	COG1595	DNA-templated transcription, initiation
B2J77_16610	COG4771	TonB-dependent receptor
B2J77_16635	COG2235	arginine
B2J77_16640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B2J77_16660	COG0786	glutamate:sodium symporter activity
B2J77_16675	COG0509	glycine decarboxylation via glycine cleavage system
B2J77_16680	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B2J77_16680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B2J77_16685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B2J77_16690	COG1278	Cold shock
B2J77_16700	COG0795	lipopolysaccharide-transporting ATPase activity
B2J77_16705	COG0795	lipopolysaccharide-transporting ATPase activity
B2J77_16715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B2J77_16730	COG0525	valine-tRNA ligase activity
B2J77_16735	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B2J77_16745	COG3081	Nucleoid-associated protein
B2J77_16750	COG2827	Endonuclease containing a URI domain
B2J77_16765	COG2807	transmembrane transport
B2J77_16770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B2J77_16775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B2J77_16780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B2J77_16785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2J77_16805	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B2J77_16810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B2J77_16815	COG1127	ABC transporter
B2J77_16825	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B2J77_16835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B2J77_16840	COG1137	ATPase activity
B2J77_16845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B2J77_16850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B2J77_16860	COG1660	Displays ATPase and GTPase activities
B2J77_16865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2J77_16895	COG0312	modulator of DNA gyrase
B2J77_16900	COG3028	Belongs to the UPF0307 family
B2J77_16905	COG0312	modulator of DNA gyrase
B2J77_16910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2J77_16920	COG1530	ribonuclease E activity
B2J77_16925	COG0424	maF-like protein
B2J77_16935	COG1792	Involved in formation and maintenance of cell shape
B2J77_16940	COG1077	Cell shape determining protein MreB Mrl
B2J77_16945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2J77_16950	COG0154	amidase activity
B2J77_16955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2J77_16970	COG1113	amino acid transport
B2J77_16980	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B2J77_16995	COG0747	negative chemotaxis
B2J77_17000	COG0747	negative chemotaxis
B2J77_17010	COG0747	negative chemotaxis
B2J77_17015	COG0601	transmembrane transport
B2J77_17020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2J77_17025	COG0444	Belongs to the ABC transporter superfamily
B2J77_17030	COG4608	Belongs to the ABC transporter superfamily
B2J77_17045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_17060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B2J77_17085	COG0019	diaminopimelate decarboxylase activity
B2J77_17090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B2J77_17095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2J77_17100	COG0436	Aminotransferase
B2J77_17110	COG1160	GTP binding
B2J77_17125	COG0124	histidyl-tRNA synthetase
B2J77_17130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B2J77_17145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B2J77_17150	COG0105	UTP biosynthetic process
B2J77_17160	COG0633	Ferredoxin
B2J77_17165	COG0443	Heat shock 70 kDa protein
B2J77_17170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B2J77_17175	COG0316	Belongs to the HesB IscA family
B2J77_17185	COG1104	cysteine desulfurase activity
B2J77_17195	COG1045	serine acetyltransferase
B2J77_17210	COG3134	Outer membrane lipoprotein
B2J77_17225	COG1862	Preprotein translocase
B2J77_17230	COG0343	queuine tRNA-ribosyltransferase activity
B2J77_17235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B2J77_17250	COG3706	GGDEF domain
B2J77_17255	COG3781	membrane
B2J77_17260	COG3639	organic phosphonate transmembrane transporter activity
B2J77_17265	COG3639	organic phosphonate transmembrane transporter activity
B2J77_17270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B2J77_17275	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B2J77_17280	COG0709	Synthesizes selenophosphate from selenide and ATP
B2J77_17285	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B2J77_17315	COG0436	Aminotransferase
B2J77_17320	COG0109	protoheme IX farnesyltransferase activity
B2J77_17330	COG1845	cytochrome c oxidase, subunit III
B2J77_17335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B2J77_17340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B2J77_17345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B2J77_17350	COG1017	nitric oxide dioxygenase activity
B2J77_17350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B2J77_17355	COG3604	Transcriptional regulator
B2J77_17405	COG2203	Gaf domain
B2J77_17405	COG4251	negative regulation of phosphorylation
B2J77_17405	COG5001	Diguanylate cyclase
B2J77_17405	COG3706	GGDEF domain
B2J77_17415	COG3530	Putative quorum-sensing-regulated virulence factor
B2J77_17420	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B2J77_17420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2J77_17420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B2J77_17425	COG1105	Belongs to the carbohydrate kinase PfkB family
B2J77_17435	COG1609	Transcriptional regulator
B2J77_17440	COG0084	hydrolase, TatD family'
B2J77_17445	COG3725	Membrane protein required for beta-lactamase induction
B2J77_17450	COG3023	N-Acetylmuramoyl-L-alanine amidase
B2J77_17465	COG0492	ferredoxin-NADP+ reductase activity
B2J77_17470	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B2J77_17490	COG0386	Belongs to the glutathione peroxidase family
B2J77_17505	COG0280	phosphate acetyltransferase
B2J77_17505	COG0857	belongs to the CobB CobQ family
B2J77_17510	COG2885	chlorophyll binding
B2J77_17525	COG2909	trisaccharide binding
B2J77_17540	COG0318	PFAM AMP-dependent synthetase and ligase
B2J77_17545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2J77_17550	COG2813	Specifically methylates the guanine in position
B2J77_17555	COG2119	membrane
B2J77_17560	COG0501	Belongs to the peptidase M48B family
B2J77_17565	COG2135	peptidase activity
B2J77_17605	COG0579	oxidoreductase
B2J77_17625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B2J77_17635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B2J77_17640	COG1090	epimerase
B2J77_17645	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B2J77_17655	COG0789	Transcriptional regulator
B2J77_17670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B2J77_17675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B2J77_17685	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B2J77_17690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B2J77_17710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B2J77_17715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B2J77_17725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B2J77_17730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B2J77_17735	COG0193	aminoacyl-tRNA hydrolase activity
B2J77_17755	COG3264	Mechanosensitive ion channel
B2J77_17755	COG1511	domain protein
B2J77_17760	COG2169	Transcriptional regulator
B2J77_17760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2J77_17765	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B2J77_17770	COG1595	DNA-templated transcription, initiation
B2J77_17785	COG2223	nitrite transmembrane transporter activity
B2J77_17800	COG0456	acetyltransferase
B2J77_17825	COG3045	CreA protein
B2J77_17830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B2J77_17835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B2J77_17840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B2J77_17845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B2J77_17850	COG0142	geranyltranstransferase activity
B2J77_17855	COG2824	Alkylphosphonate utilization operon protein PhnA
B2J77_17865	COG0545	Peptidyl-prolyl cis-trans isomerase
B2J77_17870	COG2862	Uncharacterized protein family, UPF0114
B2J77_17880	COG1067	ATP-dependent peptidase activity
B2J77_17900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2J77_17910	COG0488	(ABC) transporter
B2J77_17925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2J77_17930	COG2197	response regulator
B2J77_17935	COG2205	protein histidine kinase activity
B2J77_17935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_17940	COG2200	EAL domain
B2J77_17940	COG2199	diguanylate cyclase activity
B2J77_17940	COG2202	Pas domain
B2J77_17945	COG2205	protein histidine kinase activity
B2J77_17945	COG0784	Response regulator, receiver
B2J77_17950	COG3121	Chaperone
B2J77_17960	COG3188	usher protein
B2J77_17965	COG3121	Chaperone
B2J77_17980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2J77_17990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2J77_17995	COG0765	amino acid transport
B2J77_18010	COG4191	Histidine kinase
B2J77_18010	COG0784	Response regulator, receiver
B2J77_18050	COG0653	protein targeting
B2J77_18090	COG0582	viral genome integration into host DNA
B2J77_18115	COG0237	dephospho-CoA kinase activity
B2J77_18120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B2J77_18135	COG1252	NADH dehydrogenase
B2J77_18140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_18160	COG0542	response to heat
B2J77_18185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_18215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B2J77_18220	COG1047	Peptidyl-prolyl cis-trans
B2J77_18225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B2J77_18230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B2J77_18235	COG0196	riboflavin kinase activity
B2J77_18245	COG0268	Binds directly to 16S ribosomal RNA
B2J77_18250	COG3008	intermembrane lipid transfer
B2J77_18255	COG2995	paraquat-inducible protein a
B2J77_18260	COG2995	paraquat-inducible protein a
B2J77_18305	COG1309	transcriptional regulator
B2J77_18315	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_18320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B2J77_18330	COG2814	Major facilitator Superfamily
B2J77_18335	COG2217	Heavy metal translocating P-type atpase
B2J77_18345	COG2217	Heavy metal translocating P-type atpase
B2J77_18360	COG2207	Transcriptional regulator
B2J77_18365	COG0183	Belongs to the thiolase family
B2J77_18380	COG1028	Short-chain dehydrogenase reductase Sdr
B2J77_18395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B2J77_18415	COG0745	RESPONSE REGULATOR receiver
B2J77_18420	COG4953	penicillin-binding protein 1C
B2J77_18430	COG2373	Large extracellular alpha-helical protein
B2J77_18435	COG0534	Mate efflux family protein
B2J77_18440	COG1166	arginine decarboxylase activity
B2J77_18445	COG0023	Translation Initiation Factor
B2J77_18460	COG0745	RESPONSE REGULATOR receiver
B2J77_18460	COG3706	GGDEF domain
B2J77_18475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B2J77_18490	COG3284	Transcriptional regulator
B2J77_18495	COG3199	ATP-NAD kinase
B2J77_18500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B2J77_18505	COG0022	dehydrogenase e1 component
B2J77_18515	COG1063	alcohol dehydrogenase
B2J77_18525	COG0702	epimerase
B2J77_18540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B2J77_18545	COG3284	Transcriptional regulator
B2J77_18550	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_18555	COG0531	amino acid
B2J77_18560	COG4303	Ethanolamine ammonia lyase large subunit
B2J77_18565	COG4302	ethanolamine ammonia-lyase activity
B2J77_18570	COG0586	Pfam SNARE associated Golgi protein
B2J77_18580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B2J77_18610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B2J77_18615	COG1722	exodeoxyribonuclease VII activity
B2J77_18620	COG0142	geranyltranstransferase activity
B2J77_18625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B2J77_18630	COG4206	TonB-dependent receptor
B2J77_18635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B2J77_18645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B2J77_18655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B2J77_18660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B2J77_18665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2J77_18670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B2J77_18685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B2J77_18685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B2J77_18690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B2J77_18700	COG2264	protein methyltransferase activity
B2J77_18705	COG3118	belongs to the thioredoxin family
B2J77_18720	COG0577	efflux transmembrane transporter activity
B2J77_18720	COG1136	(ABC) transporter
B2J77_18735	COG3047	cAMP biosynthetic process
B2J77_18740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2J77_18755	COG1115	amino acid carrier protein
B2J77_18760	COG0252	asparaginase activity
B2J77_18770	COG3276	selenocysteine insertion sequence binding
B2J77_18775	COG1921	L-seryl-tRNASec selenium transferase activity
B2J77_18780	COG3058	Necessary for formate dehydrogenase activity
B2J77_18785	COG2864	formate dehydrogenase
B2J77_18790	COG0437	4 iron, 4 sulfur cluster binding
B2J77_18795	COG0243	molybdopterin cofactor binding
B2J77_18795	COG3383	formate dehydrogenase (NAD+) activity
B2J77_18800	COG0243	molybdopterin cofactor binding
B2J77_18800	COG3383	formate dehydrogenase (NAD+) activity
B2J77_18805	COG0629	single-stranded DNA binding
B2J77_18810	COG2814	Major facilitator Superfamily
B2J77_18815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B2J77_18820	COG2193	ferroxidase activity
B2J77_18825	COG0753	catalase activity
B2J77_18830	COG0203	ribosomal protein L17
B2J77_18835	COG0202	RNA polymerase activity
B2J77_18840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B2J77_18845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B2J77_18850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B2J77_18855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B2J77_18865	COG0200	Binds to the 23S rRNA
B2J77_18870	COG1841	ribosomal large subunit assembly
B2J77_18875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B2J77_18880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B2J77_18885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B2J77_18890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B2J77_18895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B2J77_18900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B2J77_18905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B2J77_18910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B2J77_18915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B2J77_18920	COG0255	Belongs to the universal ribosomal protein uL29 family
B2J77_18925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B2J77_18930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B2J77_18940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B2J77_18945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B2J77_18950	COG0089	rRNA binding
B2J77_18955	COG0088	Forms part of the polypeptide exit tunnel
B2J77_18960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B2J77_18965	COG0051	transcription antitermination factor activity, RNA binding
B2J77_18970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2J77_18975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2J77_18980	COG0049	tRNA binding
B2J77_18985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B2J77_18990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B2J77_18995	COG0085	RNA polymerase activity
B2J77_19000	COG0222	ribosome binding
B2J77_19005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B2J77_19010	COG0081	regulation of translation
B2J77_19015	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B2J77_19035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2J77_19060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B2J77_19065	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B2J77_19065	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B2J77_19095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B2J77_19100	COG0739	heme binding
B2J77_19105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B2J77_19110	COG0316	Belongs to the HesB IscA family
B2J77_19115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2J77_19125	COG0300	oxidoreductase activity
B2J77_19130	COG0537	adenosine 5'-monophosphoramidase activity
B2J77_19135	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B2J77_19145	COG1765	OsmC-like protein
B2J77_19160	COG0134	indole-3-glycerol-phosphate synthase activity
B2J77_19165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B2J77_19170	COG0512	Glutamine amidotransferase of anthranilate synthase
B2J77_19175	COG3240	lipase activity
B2J77_19175	COG4625	pathogenesis
B2J77_19180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B2J77_19185	COG0546	phosphoglycolate phosphatase activity
B2J77_19190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B2J77_19200	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2J77_19210	COG3842	ATPase activity
B2J77_19215	COG2197	response regulator
B2J77_19235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B2J77_19240	COG3178	'Phosphotransferase
B2J77_19245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B2J77_19250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2J77_19255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B2J77_19260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B2J77_19265	COG2967	ApaG domain
B2J77_19270	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2J77_19275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2J77_19280	COG2766	serine protein kinase
B2J77_19285	COG2718	Belongs to the UPF0229 family
B2J77_19290	COG2719	SpoVR family
B2J77_19295	COG0617	tRNA 3'-terminal CCA addition
B2J77_19305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B2J77_19310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B2J77_19315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B2J77_19320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B2J77_19325	COG0358	DNA primase activity
B2J77_19395	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B2J77_19405	COG1396	sequence-specific DNA binding
B2J77_19425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2J77_19430	COG1025	Belongs to the peptidase M16 family
B2J77_19440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B2J77_19445	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B2J77_19455	COG0535	radical SAM domain protein
B2J77_19470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2J77_19475	COG0583	DNA-binding transcription factor activity
B2J77_19480	COG1960	acyl-CoA dehydrogenase activity
B2J77_19485	COG3706	GGDEF domain
B2J77_19490	COG1960	acyl-CoA dehydrogenase activity
B2J77_19510	COG1073	alpha beta
B2J77_19510	COG2226	methyltransferase
B2J77_19515	COG0156	8-amino-7-oxononanoate synthase activity
B2J77_19520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B2J77_19530	COG3585	molybdate ion transport
B2J77_19530	COG2005	Transcriptional regulator
B2J77_19535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B2J77_19550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B2J77_19565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2J77_19595	COG0438	transferase activity, transferring glycosyl groups
B2J77_19605	COG0859	PFAM glycosyl transferase family 9
B2J77_19610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B2J77_19635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2J77_19650	COG0204	Acyl-transferase
B2J77_19655	COG0531	amino acid
B2J77_19695	COG1063	alcohol dehydrogenase
B2J77_19730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2J77_19755	COG1017	nitric oxide dioxygenase activity
B2J77_19755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B2J77_19780	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B2J77_19785	COG0247	lactate metabolic process
B2J77_19785	COG2181	nitrate reductase activity
B2J77_19790	COG1902	pentaerythritol trinitrate reductase activity
B2J77_19790	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2J77_19830	COG3246	L-lysine catabolic process to acetate
B2J77_19835	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2J77_19855	COG1760	l-serine dehydratase
B2J77_19865	COG4176	ABC-type proline glycine betaine transport system permease component
B2J77_19870	COG4175	Glycine betaine
B2J77_19875	COG3263	regulation of cellular component size
B2J77_19880	COG3264	Mechanosensitive ion channel
B2J77_19880	COG1196	nuclear chromosome segregation
B2J77_19885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B2J77_19890	COG3118	belongs to the thioredoxin family
B2J77_19905	COG1192	Involved in chromosome partitioning
B2J77_19925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B2J77_19940	COG0583	DNA-binding transcription factor activity
B2J77_19945	COG2814	Major facilitator Superfamily
B2J77_19955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B2J77_19960	COG0493	'glutamate synthase
B2J77_19965	COG0069	glutamate synthase activity
B2J77_19965	COG0067	glutamate synthase
B2J77_19965	COG0070	glutamate synthase
B2J77_19975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B2J77_19980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B2J77_20010	COG0281	malic enzyme
B2J77_20020	COG0254	rRNA binding
B2J77_20025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B2J77_20030	COG0018	arginyl-trna synthetase
B2J77_20045	COG0791	NLP P60 protein
B2J77_20070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2J77_20075	COG2813	Specifically methylates the guanine in position
B2J77_20075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2J77_20085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B2J77_20090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B2J77_20100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B2J77_20105	COG2022	thiamine diphosphate biosynthetic process
B2J77_20115	COG2363	Small membrane protein
B2J77_20120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B2J77_20130	COG2177	Part of the ABC transporter FtsEX involved in
B2J77_20135	COG2884	Cell division ATP-binding protein ftsE
B2J77_20140	COG0552	protein localization to endoplasmic reticulum
B2J77_20150	COG0612	Peptidase, M16
B2J77_20155	COG0612	Peptidase, M16
B2J77_20160	COG0742	ribosomal rna small subunit methyltransferase
B2J77_20165	COG0612	Peptidase, M16
B2J77_20175	COG0429	hydrolase of the alpha beta-hydrolase fold
B2J77_20185	COG1309	transcriptional regulator
B2J77_20190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B2J77_20195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B2J77_20200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B2J77_20205	COG1639	'signal transduction protein
B2J77_20210	COG0693	protein deglycase activity
B2J77_20215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B2J77_20220	COG2239	Acts as a magnesium transporter
B2J77_20225	COG0129	dihydroxy-acid dehydratase activity
B2J77_20245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2J77_20255	COG0789	Transcriptional regulator
B2J77_20385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B2J77_20405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B2J77_20410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B2J77_20415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B2J77_20420	COG0730	response to heat
B2J77_20430	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B2J77_20435	COG0494	nUDIX hydrolase
B2J77_20445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2J77_20450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B2J77_20455	COG3204	pilus organization
B2J77_20465	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2J77_20470	COG0277	FAD linked oxidase domain protein
B2J77_20475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2J77_20515	COG3829	transcription factor binding
B2J77_20525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B2J77_20530	COG4208	sulfate ABC transporter
B2J77_20540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B2J77_20550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B2J77_20560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2J77_20565	COG1177	transmembrane transport
B2J77_20570	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2J77_20575	COG3842	ATPase activity
B2J77_20595	COG0174	glutamine synthetase
B2J77_20605	COG0174	glutamine synthetase
B2J77_20610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2J77_20610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B2J77_20625	COG1522	sequence-specific DNA binding
B2J77_20645	COG0509	glycine decarboxylation via glycine cleavage system
B2J77_20650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B2J77_20655	COG1178	ABC-type Fe3 transport system permease component
B2J77_20665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2J77_20675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2J77_20680	COG0006	proline dipeptidase activity
B2J77_20685	COG3079	Belongs to the UPF0149 family
B2J77_20705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B2J77_20725	COG0604	alcohol dehydrogenase
B2J77_20740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B2J77_20755	COG0248	Ppx GppA phosphatase
B2J77_20760	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B2J77_20765	COG0586	Pfam SNARE associated Golgi protein
B2J77_20770	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B2J77_20775	COG1671	Belongs to the UPF0178 family
B2J77_20780	COG3072	Adenylate cyclase
B2J77_20785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2J77_20795	COG1965	Belongs to the frataxin family
B2J77_20810	COG0019	diaminopimelate decarboxylase activity
B2J77_20815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B2J77_20825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B2J77_20830	COG0546	phosphoglycolate phosphatase activity
B2J77_20840	COG0004	ammonium transporteR
B2J77_20845	COG0347	Belongs to the P(II) protein family
B2J77_20860	COG0606	chelatase, subunit chli
B2J77_20865	COG2267	carboxylic ester hydrolase activity
B2J77_20875	COG0583	DNA-binding transcription factor activity
B2J77_20895	COG1335	isochorismatase
B2J77_20905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_20910	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_20915	COG0583	DNA-binding transcription factor activity
B2J77_20920	COG5383	Protein conserved in bacteria
B2J77_20935	COG0534	Mate efflux family protein
B2J77_20950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B2J77_20955	COG0427	acetyl-CoA hydrolase
B2J77_20975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B2J77_20980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_20985	COG1522	sequence-specific DNA binding
B2J77_20995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2J77_21005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2J77_21010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2J77_21020	COG1012	belongs to the aldehyde dehydrogenase family
B2J77_21030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B2J77_21035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B2J77_21040	COG0747	negative chemotaxis
B2J77_21045	COG2003	Belongs to the UPF0758 family
B2J77_21050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B2J77_21055	COG0756	dUTP diphosphatase activity
B2J77_21060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2J77_21065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2J77_21070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B2J77_21075	COG0708	Exodeoxyribonuclease III
B2J77_21085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B2J77_21090	COG1561	YicC-like family, N-terminal region
B2J77_21095	COG0194	GDP metabolic process
B2J77_21105	COG0174	glutamine synthetase
B2J77_21115	COG1758	RNA polymerase activity
B2J77_21120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2J77_21145	COG0848	biopolymer transport protein
B2J77_21155	COG0583	DNA-binding transcription factor activity
B2J77_21160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B2J77_21190	COG3161	chorismate lyase activity
B2J77_21195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B2J77_21210	COG1253	flavin adenine dinucleotide binding
B2J77_21215	COG0739	heme binding
B2J77_21225	COG0704	Plays a role in the regulation of phosphate uptake
B2J77_21230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B2J77_21235	COG0573	inorganic phosphate transmembrane transporter activity
B2J77_21250	COG0477	Major facilitator Superfamily
B2J77_21255	COG1607	acyl-coa hydrolase
B2J77_21290	COG0583	DNA-binding transcription factor activity
B2J77_21295	COG1027	Aspartate ammonia-lyase
B2J77_21335	COG0511	ligase activity, forming carbon-carbon bonds
B2J77_21335	COG5016	pyruvate
B2J77_21340	COG0439	Biotin carboxylase
B2J77_21345	COG0583	DNA-binding transcription factor activity
B2J77_21360	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B2J77_21370	COG0210	DNA helicase
B2J77_21385	COG4651	solute:proton antiporter activity
B2J77_21385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B2J77_21390	COG1607	acyl-coa hydrolase
B2J77_21395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B2J77_21405	COG0523	cobalamin synthesis protein
B2J77_21420	COG1469	GTP cyclohydrolase I activity
B2J77_21430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2J77_21435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B2J77_21445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B2J77_21450	COG1349	DNA-binding transcription factor activity