locus-tag	class	description
H681_00030	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H681_00050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H681_00060	COG0484	heat shock protein binding
H681_00140	COG2856	Zn peptidase
H681_00200	COG2818	Glycosylase
H681_00220	COG1126	abc transporter atp-binding protein
H681_00225	COG0765	amino acid transport
H681_00230	COG0765	amino acid transport
H681_00235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_00240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_00245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H681_00250	COG2423	ornithine cyclodeaminase activity
H681_00255	COG0006	proline dipeptidase activity
H681_00260	COG3608	succinylglutamate desuccinylase aspartoacylase
H681_00265	COG1522	sequence-specific DNA binding
H681_00270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H681_00275	COG1012	belongs to the aldehyde dehydrogenase family
H681_00280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H681_00290	COG0569	domain protein
H681_00310	COG1652	LysM domain
H681_00315	COG0758	DNA mediated transformation
H681_00335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H681_00340	COG0659	secondary active sulfate transmembrane transporter activity
H681_00350	COG3119	arylsulfatase activity
H681_00355	COG0583	DNA-binding transcription factor activity
H681_00365	COG1595	DNA-templated transcription, initiation
H681_00385	COG2207	Transcriptional regulator
H681_00390	COG0346	lactoylglutathione lyase activity
H681_00415	COG3360	Dodecin
H681_00445	COG1250	3-hydroxyacyl-CoA dehydrogenase
H681_00450	COG0318	PFAM AMP-dependent synthetase and ligase
H681_00465	COG1960	acyl-CoA dehydrogenase activity
H681_00470	COG1250	3-hydroxyacyl-CoA dehydrogenase
H681_00470	COG1024	Enoyl-CoA hydratase
H681_00475	COG2267	carboxylic ester hydrolase activity
H681_00480	COG2153	protein acetylation
H681_00565	COG2755	lipolytic protein G-D-S-L family
H681_00565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H681_00585	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H681_00585	COG0662	Cupin 2, conserved barrel domain protein
H681_00605	COG0438	transferase activity, transferring glycosyl groups
H681_00620	COG0427	acetyl-CoA hydrolase
H681_00625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H681_00630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H681_00635	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H681_00675	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H681_00680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H681_00685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H681_00705	COG0306	phosphate transporter
H681_00735	COG2072	flavoprotein involved in K transport
H681_00765	COG0454	-acetyltransferase
H681_00770	COG3706	GGDEF domain
H681_00795	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H681_00805	COG0840	transmembrane signaling receptor activity
H681_00810	COG0835	chemotaxis
H681_00820	COG0745	RESPONSE REGULATOR receiver
H681_00840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H681_00845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H681_00855	COG4771	TonB-dependent receptor
H681_00880	COG0477	Major facilitator Superfamily
H681_00885	COG2207	Transcriptional regulator
H681_00900	COG1309	transcriptional regulator
H681_00910	COG0840	transmembrane signaling receptor activity
H681_00920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H681_00980	COG2011	ABC-type metal ion transport system permease component
H681_00995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H681_01005	COG0735	belongs to the Fur family
H681_01010	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H681_01065	COG3706	GGDEF domain
H681_01065	COG0745	RESPONSE REGULATOR receiver
H681_01070	COG1349	DNA-binding transcription factor activity
H681_01085	COG0463	Glycosyl transferase, family 2
H681_01090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H681_01105	COG0477	Major facilitator Superfamily
H681_01110	COG0477	Major facilitator Superfamily
H681_01115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H681_01120	COG0456	acetyltransferase
H681_01150	COG0523	cobalamin synthesis protein
H681_01165	COG0387	Pfam Sodium calcium exchanger
H681_01170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H681_01175	COG0659	secondary active sulfate transmembrane transporter activity
H681_01180	COG2076	Multidrug Resistance protein
H681_01205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H681_01250	COG2972	Histidine kinase
H681_01250	COG0745	RESPONSE REGULATOR receiver
H681_01310	COG0488	(ABC) transporter
H681_01320	COG0861	Integral membrane protein TerC family
H681_01330	COG1280	lysine exporter protein (LysE YggA)
H681_01335	COG0672	)-iron permease
H681_01340	COG1671	Belongs to the UPF0178 family
H681_01345	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H681_01355	COG0586	Pfam SNARE associated Golgi protein
H681_01370	COG0248	Ppx GppA phosphatase
H681_01395	COG0604	alcohol dehydrogenase
H681_01405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_01410	COG0842	Transport permease protein
H681_01410	COG1129	ABC transporter
H681_01415	COG0842	Transport permease protein
H681_01420	COG0745	RESPONSE REGULATOR receiver
H681_01420	COG3706	GGDEF domain
H681_01435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H681_01455	COG0006	proline dipeptidase activity
H681_01460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H681_01465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H681_01475	COG1178	ABC-type Fe3 transport system permease component
H681_01540	COG1454	alcohol dehydrogenase
H681_01545	COG0824	Thioesterase
H681_01570	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H681_01575	COG0583	DNA-binding transcription factor activity
H681_01580	COG1652	LysM domain
H681_01585	COG1011	Hydrolase
H681_01590	COG0494	nUDIX hydrolase
H681_01625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H681_01630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H681_01635	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H681_01660	COG0429	hydrolase of the alpha beta-hydrolase fold
H681_01670	COG0742	ribosomal rna small subunit methyltransferase
H681_01675	COG0612	Peptidase, M16
H681_01680	COG0612	Peptidase, M16
H681_01685	COG0552	protein localization to endoplasmic reticulum
H681_01690	COG2884	Cell division ATP-binding protein ftsE
H681_01695	COG2177	Part of the ABC transporter FtsEX involved in
H681_01715	COG2363	Small membrane protein
H681_01730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H681_01750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H681_01765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H681_01765	COG2813	Specifically methylates the guanine in position
H681_01780	COG1872	DUF167
H681_01815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H681_01820	COG0626	cystathionine gamma-synthase activity
H681_01900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H681_01915	COG3038	cytochrome b561
H681_01950	COG0840	transmembrane signaling receptor activity
H681_01955	COG0840	transmembrane signaling receptor activity
H681_01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H681_02065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H681_02085	COG0281	malic enzyme
H681_02095	COG0330	HflC and HflK could
H681_02110	COG1289	transmembrane transporter activity
H681_02115	COG0513	Belongs to the DEAD box helicase family
H681_02125	COG0189	ligase activity
H681_02125	COG4067	protein conserved in archaea
H681_02130	COG0477	Major facilitator Superfamily
H681_02145	COG0204	Acyl-transferase
H681_02155	COG0745	RESPONSE REGULATOR receiver
H681_02160	COG2205	protein histidine kinase activity
H681_02165	COG4452	Inner membrane protein CreD
H681_02195	COG4774	siderophore transport
H681_02200	COG3712	iron ion homeostasis
H681_02205	COG1595	DNA-templated transcription, initiation
H681_02215	COG1953	Uracil, thiamine, allantoin
H681_02245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H681_02255	COG3585	molybdate ion transport
H681_02255	COG2005	Transcriptional regulator
H681_02260	COG1040	competence protein
H681_02280	COG0511	ligase activity, forming carbon-carbon bonds
H681_02285	COG0439	Biotin carboxylase
H681_02295	COG1984	allophanate hydrolase subunit 2
H681_02315	COG2226	methyltransferase
H681_02315	COG1073	alpha beta
H681_02335	COG1960	acyl-CoA dehydrogenase activity
H681_02340	COG3706	GGDEF domain
H681_02340	COG0745	RESPONSE REGULATOR receiver
H681_02345	COG1960	acyl-CoA dehydrogenase activity
H681_02350	COG1960	acyl-CoA dehydrogenase activity
H681_02355	COG0583	DNA-binding transcription factor activity
H681_02360	COG2258	MOSC domain
H681_02370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H681_02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_02390	COG0174	glutamine synthetase
H681_02425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H681_02440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H681_02460	COG2719	SpoVR family
H681_02470	COG2766	serine protein kinase
H681_02495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H681_02510	COG3344	reverse transcriptase
H681_02530	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H681_02545	COG2197	response regulator
H681_02555	COG3842	ATPase activity
H681_02565	COG1176	ABC-type spermidine putrescine transport system, permease component I
H681_02575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H681_02610	COG1765	OsmC-like protein
H681_02625	COG0537	adenosine 5'-monophosphoramidase activity
H681_02660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H681_02665	COG0316	Belongs to the HesB IscA family
H681_02675	COG0739	heme binding
H681_02685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H681_02690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H681_02690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H681_02760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H681_02770	COG0051	transcription antitermination factor activity, RNA binding
H681_02800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H681_02805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H681_02870	COG0200	Binds to the 23S rRNA
H681_02880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H681_02890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H681_02935	COG2814	Major facilitator Superfamily
H681_02995	COG2271	Major facilitator Superfamily
H681_03035	COG0625	glutathione transferase activity
H681_03055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H681_03090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_03095	COG0348	domain, Protein
H681_03100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H681_03115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H681_03120	COG3094	Invasion gene expression up-regulator, SirB
H681_03125	COG3047	cAMP biosynthetic process
H681_03140	COG4181	ATPase activity
H681_03155	COG3118	belongs to the thioredoxin family
H681_03160	COG2264	protein methyltransferase activity
H681_03175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H681_03175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H681_03205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H681_03215	COG3577	Aspartyl protease
H681_03220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H681_03245	COG0583	DNA-binding transcription factor activity
H681_03250	COG0586	Pfam SNARE associated Golgi protein
H681_03290	COG0768	penicillin binding
H681_03295	COG0772	Belongs to the SEDS family
H681_03300	COG2951	lytic endotransglycosylase activity
H681_03310	COG1686	Belongs to the peptidase S11 family
H681_03335	COG3121	Chaperone
H681_03340	COG3188	usher protein
H681_03350	COG2951	lytic endotransglycosylase activity
H681_03360	COG3795	YCII-related domain
H681_03395	COG4535	Mg2 and Co2 transporter CorC
H681_03405	COG1702	phosphate starvation-inducible protein PhoH
H681_03435	COG0351	phosphomethylpyrimidine kinase
H681_03440	COG0784	Response regulator, receiver
H681_03440	COG5002	protein histidine kinase activity
H681_03445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H681_03475	COG2814	Major facilitator Superfamily
H681_03485	COG1960	acyl-CoA dehydrogenase activity
H681_03490	COG1024	Enoyl-CoA hydratase
H681_03495	COG1960	acyl-CoA dehydrogenase activity
H681_03500	COG1028	Short-chain dehydrogenase reductase Sdr
H681_03520	COG1960	acyl-CoA dehydrogenase activity
H681_03535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H681_03540	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H681_03545	COG0653	protein targeting
H681_03565	COG1522	sequence-specific DNA binding
H681_03580	COG2318	DinB family
H681_03590	COG1643	Atp-dependent helicase
H681_03625	COG3416	Protein conserved in bacteria
H681_03635	COG0513	Belongs to the DEAD box helicase family
H681_03655	COG0123	including yeast histone deacetylase and acetoin utilization protein
H681_03660	COG2814	Major facilitator Superfamily
H681_03675	COG1946	Acyl-CoA thioesterase
H681_03685	COG4206	TonB-dependent receptor
H681_03690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H681_03700	COG1012	belongs to the aldehyde dehydrogenase family
H681_03705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H681_03715	COG1126	abc transporter atp-binding protein
H681_03720	COG0765	amino acid transport
H681_03725	COG0765	amino acid transport
H681_03745	COG2378	regulation of single-species biofilm formation
H681_03765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_03775	COG2186	Transcriptional regulator
H681_03780	COG0142	geranyltranstransferase activity
H681_03810	COG3501	Rhs element vgr protein
H681_03935	COG3501	Rhs element vgr protein
H681_03965	COG0738	Major facilitator superfamily
H681_03975	COG1028	Short-chain dehydrogenase reductase Sdr
H681_03985	COG4948	Mandelate Racemase Muconate Lactonizing
H681_03990	COG0179	Fumarylacetoacetate (FAA) hydrolase
H681_03995	COG1028	Short-chain dehydrogenase reductase Sdr
H681_04015	COG3228	Belongs to the MtfA family
H681_04020	COG0586	Pfam SNARE associated Golgi protein
H681_04025	COG0456	acetyltransferase
H681_04030	COG4302	ethanolamine ammonia-lyase activity
H681_04035	COG4303	Ethanolamine ammonia lyase large subunit
H681_04050	COG1012	belongs to the aldehyde dehydrogenase family
H681_04055	COG3284	Transcriptional regulator
H681_04060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H681_04075	COG0702	epimerase
H681_04095	COG1346	cytolysis
H681_04125	COG1802	Transcriptional regulator
H681_04170	COG1126	abc transporter atp-binding protein
H681_04175	COG0765	amino acid transport
H681_04180	COG0765	amino acid transport
H681_04200	COG0784	Response regulator, receiver
H681_04200	COG5002	protein histidine kinase activity
H681_04200	COG2205	protein histidine kinase activity
H681_04220	COG0697	spore germination
H681_04250	COG1309	transcriptional regulator
H681_04265	COG2814	Major facilitator Superfamily
H681_04295	COG2321	neutral zinc metallopeptidase
H681_04305	COG0436	Aminotransferase
H681_04340	COG2252	PERMEase
H681_04380	COG1061	Type III restriction enzyme res subunit
H681_04405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H681_04435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H681_04440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H681_04495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H681_04500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_04505	COG0583	DNA-binding transcription factor activity
H681_04515	COG1335	isochorismatase
H681_04525	COG1902	pentaerythritol trinitrate reductase activity
H681_04530	COG0583	DNA-binding transcription factor activity
H681_04560	COG0488	(ABC) transporter
H681_04585	COG1690	Belongs to the RtcB family
H681_04605	COG1067	ATP-dependent peptidase activity
H681_04615	COG2862	Uncharacterized protein family, UPF0114
H681_04625	COG0545	Peptidyl-prolyl cis-trans isomerase
H681_04635	COG0142	geranyltranstransferase activity
H681_04645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H681_04660	COG3045	CreA protein
H681_04670	COG0728	peptidoglycan biosynthetic process
H681_04675	COG0196	riboflavin kinase activity
H681_04690	COG1047	Peptidyl-prolyl cis-trans
H681_04785	COG0753	catalase activity
H681_04790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H681_04795	COG1252	NADH dehydrogenase
H681_04815	COG4566	intracellular signal transduction
H681_04830	COG1028	Short-chain dehydrogenase reductase Sdr
H681_04840	COG1028	Short-chain dehydrogenase reductase Sdr
H681_04880	COG1252	NADH dehydrogenase
H681_04940	COG4969	Belongs to the N-Me-Phe pilin family
H681_04960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H681_04990	COG0084	hydrolase, TatD family'
H681_04995	COG1609	Transcriptional regulator
H681_05005	COG1105	Belongs to the carbohydrate kinase PfkB family
H681_05010	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H681_05010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H681_05010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H681_05025	COG2076	Multidrug Resistance protein
H681_05035	COG0726	polysaccharide deacetylase
H681_05050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H681_05075	COG1309	transcriptional regulator
H681_05095	COG0019	diaminopimelate decarboxylase activity
H681_05100	COG2194	sulfuric ester hydrolase activity
H681_05115	COG4774	siderophore transport
H681_05120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H681_05135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H681_05140	COG1984	allophanate hydrolase subunit 2
H681_05150	COG1280	lysine exporter protein (LysE YggA)
H681_05160	COG4608	Belongs to the ABC transporter superfamily
H681_05165	COG0444	Belongs to the ABC transporter superfamily
H681_05170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H681_05175	COG0601	transmembrane transport
H681_05180	COG0747	negative chemotaxis
H681_05190	COG0747	negative chemotaxis
H681_05205	COG0747	negative chemotaxis
H681_05210	COG0747	negative chemotaxis
H681_05225	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H681_05230	COG4178	(ABC) transporter
H681_05235	COG0739	heme binding
H681_05255	COG4676	Protein conserved in bacteria
H681_05260	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
H681_05275	COG5445	Predicted secreted protein (DUF2300)
H681_05280	COG4676	Protein conserved in bacteria
H681_05285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H681_05290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H681_05295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H681_05310	COG1077	Cell shape determining protein MreB Mrl
H681_05315	COG1792	Involved in formation and maintenance of cell shape
H681_05325	COG0424	maF-like protein
H681_05330	COG1530	ribonuclease E activity
H681_05340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H681_05345	COG0312	modulator of DNA gyrase
H681_05355	COG0312	modulator of DNA gyrase
H681_05385	COG1137	ATPase activity
H681_05390	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H681_05400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H681_05410	COG1127	ABC transporter
H681_05415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H681_05420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H681_05460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H681_05470	COG2951	lytic endotransglycosylase activity
H681_05475	COG0175	sulfate reduction
H681_05490	COG2945	thiolester hydrolase activity
H681_05500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H681_05515	COG1960	acyl-CoA dehydrogenase activity
H681_05520	COG0667	Aldo Keto reductase
H681_05530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H681_05535	COG0723	plastoquinol--plastocyanin reductase activity
H681_05540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H681_05545	COG2857	Cytochrome c1
H681_05550	COG0625	glutathione transferase activity
H681_05555	COG2969	positive regulation of protein catabolic process
H681_05560	COG2823	Periplasmic or secreted lipoprotein
H681_05570	COG0792	nuclease activity
H681_05575	COG3107	peptidoglycan biosynthetic process
H681_05610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H681_05625	COG0772	Belongs to the SEDS family
H681_05685	COG0494	nUDIX hydrolase
H681_05690	COG2096	Adenosyltransferase
H681_05715	COG0668	transmembrane transport
H681_05720	COG2211	Major facilitator Superfamily
H681_05735	COG1028	Short-chain dehydrogenase reductase Sdr
H681_05740	COG0748	coenzyme F420 binding
H681_05745	COG3030	protein affecting phage T7 exclusion by the F plasmid
H681_05780	COG0642	Histidine kinase
H681_05790	COG3642	lipopolysaccharide core region biosynthetic process
H681_05805	COG0433	COG0433 Predicted ATPase
H681_05825	COG4964	Belongs to the GSP D family
H681_05865	COG4566	intracellular signal transduction
H681_05880	COG4191	Histidine kinase
H681_05885	COG0306	phosphate transporter
H681_05910	COG1230	cation diffusion facilitator family transporter
H681_05935	COG2326	polyphosphate kinase activity
H681_05940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H681_05945	COG1074	ATP-dependent DNA helicase activity
H681_05950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H681_05955	COG2205	protein histidine kinase activity
H681_05955	COG0784	Response regulator, receiver
H681_05965	COG0784	Response regulator, receiver
H681_05965	COG2205	protein histidine kinase activity
H681_05970	COG2197	response regulator
H681_06025	COG2801	Transposase and inactivated derivatives
H681_06030	COG2963	transposase activity
H681_06050	COG3501	Rhs element vgr protein
H681_06060	COG3121	Chaperone
H681_06070	COG3188	usher protein
H681_06075	COG3121	Chaperone
H681_06085	COG3795	YCII-related domain
H681_06105	COG4941	Belongs to the sigma-70 factor family
H681_06115	COG1566	PFAM secretion protein HlyD family protein
H681_06125	COG1028	Short-chain dehydrogenase reductase Sdr
H681_06130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H681_06135	COG3706	GGDEF domain
H681_06165	COG3220	belongs to the UPF0276 family
H681_06175	COG1764	response to oxidative stress
H681_06180	COG2259	Doxx family
H681_06195	COG0745	RESPONSE REGULATOR receiver
H681_06295	COG0633	Ferredoxin
H681_06300	COG0789	Transcriptional regulator
H681_06335	COG4974	Belongs to the 'phage' integrase family
H681_06360	COG1566	PFAM secretion protein HlyD family protein
H681_06395	COG2130	NADP-dependent
H681_06415	COG3039	Transposase
H681_06460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H681_06460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H681_06485	COG4206	TonB-dependent receptor
H681_06490	COG4974	Belongs to the 'phage' integrase family
H681_06510	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H681_06555	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H681_06565	COG3300	MHYT domain
H681_06565	COG5001	Diguanylate cyclase
H681_06580	COG1538	Outer membrane efflux protein
H681_06590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_06595	COG2910	NAD(P)H-binding
H681_06600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H681_06615	COG1024	Enoyl-CoA hydratase
H681_06640	COG3180	Ammonia monooxygenase
H681_06715	COG3086	response to oxidative stress
H681_06720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H681_06755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H681_06790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H681_06795	COG2207	Transcriptional regulator
H681_06805	COG4206	TonB-dependent receptor
H681_06815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H681_06825	COG0583	DNA-binding transcription factor activity
H681_06830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H681_06835	COG2076	Multidrug Resistance protein
H681_06840	COG4628	conserved protein (DUF2132)
H681_06855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H681_06860	COG1113	amino acid transport
H681_06865	COG0501	Belongs to the peptidase M48B family
H681_06870	COG1704	LemA family
H681_06875	COG1335	isochorismatase
H681_06890	COG0662	Cupin 2, conserved barrel domain protein
H681_06900	COG4206	TonB-dependent receptor
H681_06915	COG1181	Belongs to the D-alanine--D-alanine ligase family
H681_06920	COG0656	L-ascorbic acid biosynthetic process
H681_06930	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H681_06940	COG3011	Protein conserved in bacteria
H681_06955	COG4772	TonB-dependent receptor
H681_06970	COG0583	DNA-binding transcription factor activity
H681_06975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H681_06980	COG0069	glutamate synthase activity
H681_06985	COG1760	l-serine dehydratase
H681_07000	COG0531	amino acid
H681_07010	COG0477	Major facilitator Superfamily
H681_07015	COG0583	DNA-binding transcription factor activity
H681_07020	COG1960	acyl-CoA dehydrogenase activity
H681_07025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H681_07030	COG1024	Enoyl-CoA hydratase
H681_07035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H681_07040	COG0183	Belongs to the thiolase family
H681_07050	COG0583	DNA-binding transcription factor activity
H681_07090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H681_07100	COG3842	ATPase activity
H681_07115	COG0243	molybdopterin cofactor binding
H681_07120	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H681_07135	COG2906	2 iron, 2 sulfur cluster binding
H681_07140	COG0450	alkyl hydroperoxide reductase
H681_07165	COG0346	lactoylglutathione lyase activity
H681_07170	COG1611	Belongs to the LOG family
H681_07180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H681_07230	COG0489	protein tyrosine kinase activity
H681_07250	COG0653	protein targeting
H681_07265	COG2860	membrane
H681_07300	COG1199	ATP-dependent helicase activity
H681_07315	COG2885	chlorophyll binding
H681_07325	COG1929	Belongs to the glycerate kinase type-1 family
H681_07335	COG3133	Outer membrane lipoprotein
H681_07340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H681_07340	COG2111	Na H antiporter
H681_07345	COG1006	Multisubunit Na H antiporter MnhC subunit
H681_07350	COG0651	ATP synthesis coupled electron transport
H681_07360	COG2212	antiporter activity
H681_07365	COG1320	monovalent cation:proton antiporter activity
H681_07380	COG1794	racemase activity, acting on amino acids and derivatives
H681_07390	COG3189	MarR family transcriptional regulator
H681_07400	COG0583	DNA-binding transcription factor activity
H681_07410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H681_07425	COG1028	Short-chain dehydrogenase reductase Sdr
H681_07430	COG1802	Transcriptional regulator
H681_07450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H681_07465	COG1131	(ABC) transporter
H681_07495	COG2226	methyltransferase
H681_07510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H681_07530	COG1280	lysine exporter protein (LysE YggA)
H681_07535	COG1393	Belongs to the ArsC family
H681_07540	COG0025	NhaP-type Na H and K H
H681_07545	COG0436	Aminotransferase
H681_07555	COG0024	Methionine aminopeptidase
H681_07565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H681_07600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H681_07630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H681_07640	COG0825	malonyl-CoA metabolic process
H681_07645	COG0037	tRNA processing
H681_07655	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H681_07660	COG0148	phosphopyruvate hydratase activity
H681_07675	COG0425	Belongs to the sulfur carrier protein TusA family
H681_07680	COG2391	methyltransferase activity
H681_07685	COG0583	DNA-binding transcription factor activity
H681_07690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H681_07695	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H681_07700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H681_07705	COG0585	pseudouridine synthase activity
H681_07740	COG1546	Belongs to the CinA family
H681_07760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H681_07770	COG3530	Putative quorum-sensing-regulated virulence factor
H681_07830	COG4807	Protein conserved in bacteria
H681_07835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H681_07845	COG3038	cytochrome b561
H681_07855	COG0392	lysyltransferase activity
H681_07855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H681_07860	COG2365	Tyrosine phosphatase family
H681_07865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H681_07880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H681_07885	COG5002	protein histidine kinase activity
H681_07885	COG2205	protein histidine kinase activity
H681_07885	COG0784	Response regulator, receiver
H681_07910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H681_07915	COG3956	TIGRFAM MazG family protein
H681_07925	COG3122	Protein conserved in bacteria
H681_07945	COG1846	Transcriptional regulator
H681_07950	COG2067	long-chain fatty acid transport protein
H681_07990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H681_08000	COG2983	Belongs to the UPF0260 family
H681_08010	COG1770	oligopeptidase
H681_08025	COG0121	glutamine amidotransferase
H681_08040	COG1247	-acetyltransferase
H681_08045	COG0697	spore germination
H681_08060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H681_08070	COG0542	response to heat
H681_08090	COG4106	trans-aconitate 2-methyltransferase activity
H681_08095	COG1196	nuclear chromosome segregation
H681_08095	COG3264	Mechanosensitive ion channel
H681_08105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_08115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H681_08155	COG0488	(ABC) transporter
H681_08185	COG2274	protein secretion by the type I secretion system
H681_08200	COG0183	Belongs to the thiolase family
H681_08210	COG0450	alkyl hydroperoxide reductase
H681_08215	COG0431	NADPH-dependent FMN reductase
H681_08220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H681_08230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H681_08250	COG0697	spore germination
H681_08290	COG0271	Belongs to the BolA IbaG family
H681_08320	COG5001	Diguanylate cyclase
H681_08320	COG5002	protein histidine kinase activity
H681_08330	COG1063	alcohol dehydrogenase
H681_08350	COG0625	glutathione transferase activity
H681_08355	COG1113	amino acid transport
H681_08375	COG1620	l-lactate permease
H681_08380	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H681_08385	COG0247	lactate metabolic process
H681_08390	COG0277	FAD linked oxidase domain protein
H681_08395	COG0277	FAD linked oxidase domain protein
H681_08400	COG2186	Transcriptional regulator
H681_08415	COG0446	pyridine nucleotide-disulphide oxidoreductase
H681_08415	COG1902	pentaerythritol trinitrate reductase activity
H681_08420	COG3971	2-oxopent-4-enoate hydratase activity
H681_08485	COG1215	transferase activity, transferring glycosyl groups
H681_08520	COG0791	NLP P60 protein
H681_08530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H681_08535	COG0477	Major facilitator Superfamily
H681_08540	COG0513	Belongs to the DEAD box helicase family
H681_08565	COG0583	DNA-binding transcription factor activity
H681_08585	COG4215	(ABC) transporter
H681_08645	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H681_08650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H681_08670	COG2239	Acts as a magnesium transporter
H681_08695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H681_08700	COG0583	DNA-binding transcription factor activity
H681_08705	COG3842	ATPase activity
H681_08715	COG1840	ABC-type Fe3 transport system, periplasmic component
H681_08735	COG0477	Major facilitator Superfamily
H681_08740	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H681_08760	COG0835	chemotaxis
H681_08760	COG0784	Response regulator, receiver
H681_08770	COG1815	bacterial-type flagellum-dependent cell motility
H681_08775	COG1558	bacterial-type flagellum-dependent cell motility
H681_08780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H681_08785	COG1749	Flagellar hook protein flgE
H681_08790	COG4786	Flagellar basal body rod
H681_08795	COG4786	Flagellar basal body rod
H681_08850	COG3604	Transcriptional regulator
H681_08855	COG4191	Histidine kinase
H681_08860	COG2204	response regulator
H681_08925	COG0745	RESPONSE REGULATOR receiver
H681_08965	COG1987	bacterial-type flagellum assembly
H681_08990	COG3971	2-oxopent-4-enoate hydratase activity
H681_08995	COG2271	Major facilitator Superfamily
H681_09005	COG3384	dioxygenase
H681_09010	COG1012	belongs to the aldehyde dehydrogenase family
H681_09025	COG1846	Transcriptional regulator
H681_09035	COG2814	Major facilitator Superfamily
H681_09045	COG1960	acyl-CoA dehydrogenase activity
H681_09050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H681_09055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H681_09065	COG0455	bacterial-type flagellum organization
H681_09085	COG0643	Histidine kinase
H681_09085	COG2198	Histidine kinase
H681_09090	COG2201	protein-glutamate methylesterase activity
H681_09095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H681_09105	COG1192	Involved in chromosome partitioning
H681_09115	COG0835	chemotaxis
H681_09130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H681_09220	COG0628	permease
H681_09230	COG1132	(ABC) transporter
H681_09255	COG0242	peptide deformylase activity
H681_09270	COG1295	ribonuclease BN
H681_09285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H681_09290	COG2249	NAD(P)H dehydrogenase (quinone) activity
H681_09300	COG5001	Diguanylate cyclase
H681_09300	COG4251	negative regulation of phosphorylation
H681_09300	COG3706	GGDEF domain
H681_09300	COG2203	Gaf domain
H681_09310	COG3257	ureidoglycine aminohydrolase activity
H681_09315	COG0583	DNA-binding transcription factor activity
H681_09330	COG2274	protein secretion by the type I secretion system
H681_09340	COG0438	transferase activity, transferring glycosyl groups
H681_09345	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
H681_09355	COG1943	Transposase
H681_09365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H681_09370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H681_09370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H681_09375	COG0745	RESPONSE REGULATOR receiver
H681_09380	COG2205	protein histidine kinase activity
H681_09420	COG2951	lytic endotransglycosylase activity
H681_09430	COG0745	RESPONSE REGULATOR receiver
H681_09435	COG2205	protein histidine kinase activity
H681_09440	COG1917	Cupin 2, conserved barrel domain protein
H681_09440	COG4977	sequence-specific DNA binding
H681_09460	COG2197	response regulator
H681_09465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H681_09485	COG0469	pyruvate kinase activity
H681_09495	COG2084	Dehydrogenase
H681_09500	COG3622	Belongs to the hyi family
H681_09505	COG3960	tartronate-semialdehyde synthase activity
H681_09515	COG1309	transcriptional regulator
H681_09550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_09570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H681_09615	COG1028	Short-chain dehydrogenase reductase Sdr
H681_09625	COG0179	Fumarylacetoacetate (FAA) hydrolase
H681_09690	COG3451	type IV secretory pathway VirB4
H681_09700	COG3838	Conjugal transfer protein Trbc
H681_09705	COG4962	Type ii secretion system protein e
H681_09725	COG0583	DNA-binding transcription factor activity
H681_09730	COG1309	transcriptional regulator
H681_09740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_09745	COG1131	(ABC) transporter
H681_09750	COG0842	Transport permease protein
H681_09755	COG0842	Transport permease protein
H681_09770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H681_09775	COG1611	Belongs to the LOG family
H681_09800	COG4959	Type IV secretory pathway protease TraF
H681_09845	COG5489	Protein of unknown function (DUF736)
H681_09850	COG1475	DNA binding
H681_09865	COG3077	Addiction module antitoxin, RelB DinJ family
H681_09915	COG5002	protein histidine kinase activity
H681_09915	COG0784	Response regulator, receiver
H681_09915	COG2205	protein histidine kinase activity
H681_09945	COG1285	pathogenesis
H681_09950	COG1022	Amp-dependent synthetase and ligase
H681_09965	COG1280	lysine exporter protein (LysE YggA)
H681_09985	COG0628	permease
H681_09990	COG2807	transmembrane transport
H681_09995	COG2186	Transcriptional regulator
H681_10020	COG2205	protein histidine kinase activity
H681_10025	COG0745	RESPONSE REGULATOR receiver
H681_10050	COG0667	Aldo Keto reductase
H681_10065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_10070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H681_10075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H681_10080	COG1538	Outer membrane efflux protein
H681_10085	COG2329	Antibiotic biosynthesis monooxygenase
H681_10095	COG0583	DNA-binding transcription factor activity
H681_10110	COG0583	DNA-binding transcription factor activity
H681_10115	COG1028	Short-chain dehydrogenase reductase Sdr
H681_10120	COG1289	transmembrane transporter activity
H681_10130	COG0583	DNA-binding transcription factor activity
H681_10140	COG0590	tRNA wobble adenosine to inosine editing
H681_10145	COG2807	transmembrane transport
H681_10170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_10195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H681_10210	COG2130	NADP-dependent
H681_10230	COG3135	benzoate transporter
H681_10250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_10255	COG0625	glutathione transferase activity
H681_10300	COG1073	alpha beta
H681_10305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H681_10330	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H681_10340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H681_10365	COG0730	response to heat
H681_10385	COG0300	oxidoreductase activity
H681_10395	COG0697	spore germination
H681_10405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H681_10405	COG0519	Catalyzes the synthesis of GMP from XMP
H681_10415	COG1177	transmembrane transport
H681_10420	COG1176	ABC-type spermidine putrescine transport system, permease component I
H681_10425	COG3842	ATPase activity
H681_10430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_10440	COG0183	Belongs to the thiolase family
H681_10455	COG0519	Catalyzes the synthesis of GMP from XMP
H681_10455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H681_10470	COG0598	Magnesium transport protein CorA
H681_10505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H681_10520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H681_10570	COG2909	trisaccharide binding
H681_10600	COG0189	ligase activity
H681_10610	COG4067	protein conserved in archaea
H681_10610	COG0189	ligase activity
H681_10620	COG3064	Membrane
H681_10650	COG0598	Magnesium transport protein CorA
H681_10660	COG0668	transmembrane transport
H681_10680	COG0243	molybdopterin cofactor binding
H681_10685	COG2146	nitrite reductase [NAD(P)H] activity
H681_10690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H681_10695	COG0515	serine threonine protein kinase
H681_10700	COG2223	nitrite transmembrane transporter activity
H681_10715	COG3707	response regulator
H681_10720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H681_10755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H681_10760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H681_10765	COG0215	cysteine-tRNA ligase activity
H681_10790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H681_10800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H681_10810	COG4172	Belongs to the ABC transporter superfamily
H681_10815	COG4239	(ABC) transporter, permease
H681_10820	COG4174	ABC transporter (Permease)
H681_10825	COG4166	transmembrane transport
H681_10830	COG4166	transmembrane transport
H681_10835	COG1388	LysM domain
H681_10835	COG0741	lytic transglycosylase activity
H681_10855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H681_10860	COG1982	Orn Lys Arg decarboxylase major
H681_10875	COG0531	amino acid
H681_10880	COG1024	Enoyl-CoA hydratase
H681_10890	COG2816	NAD+ diphosphatase activity
H681_10905	COG1028	Short-chain dehydrogenase reductase Sdr
H681_10925	COG0616	signal peptide processing
H681_10930	COG0604	alcohol dehydrogenase
H681_10950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H681_10970	COG0534	Mate efflux family protein
H681_10995	COG3813	Protein conserved in bacteria
H681_11010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H681_11015	COG2866	Carboxypeptidase
H681_11040	COG0028	Belongs to the TPP enzyme family
H681_11060	COG0753	catalase activity
H681_11065	COG2010	Cytochrome c
H681_11085	COG0583	DNA-binding transcription factor activity
H681_11090	COG3485	protocatechuate 3,4-dioxygenase
H681_11095	COG3485	protocatechuate 3,4-dioxygenase
H681_11100	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H681_11140	COG0318	PFAM AMP-dependent synthetase and ligase
H681_11145	COG2188	Transcriptional regulator
H681_11150	COG1414	Transcriptional regulator
H681_11165	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H681_11165	COG0506	proline dehydrogenase activity
H681_11165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H681_11185	COG0385	Bile acid
H681_11200	COG0417	DNA replication proofreading
H681_11205	COG1522	sequence-specific DNA binding
H681_11225	COG1309	transcriptional regulator
H681_11230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H681_11235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H681_11240	COG1403	HNH endonuclease
H681_11245	COG2832	Protein of unknown function (DUF454)
H681_11265	COG1595	DNA-templated transcription, initiation
H681_11270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_11285	COG0583	DNA-binding transcription factor activity
H681_11370	COG4948	Mandelate Racemase Muconate Lactonizing
H681_11375	COG4829	muconolactone delta-isomerase
H681_11380	COG3485	protocatechuate 3,4-dioxygenase
H681_11385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H681_11390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H681_11395	COG0183	Belongs to the thiolase family
H681_11405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H681_11410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H681_11415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H681_11430	COG1024	Enoyl-CoA hydratase
H681_11435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H681_11440	COG1960	acyl-CoA dehydrogenase activity
H681_11445	COG0789	Transcriptional regulator
H681_11450	COG3284	Transcriptional regulator
H681_11455	COG1132	(ABC) transporter
H681_11470	COG0625	glutathione transferase activity
H681_11475	COG1012	belongs to the aldehyde dehydrogenase family
H681_11480	COG0583	DNA-binding transcription factor activity
H681_11485	COG1477	protein flavinylation
H681_11505	COG2233	PERMEase
H681_11510	COG0583	DNA-binding transcription factor activity
H681_11535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_11550	COG0154	amidase activity
H681_11575	COG0477	Major facilitator Superfamily
H681_11625	COG1686	Belongs to the peptidase S11 family
H681_11630	COG0318	PFAM AMP-dependent synthetase and ligase
H681_11640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H681_11650	COG0183	Belongs to the thiolase family
H681_11655	COG1960	acyl-CoA dehydrogenase activity
H681_11675	COG0861	Integral membrane protein TerC family
H681_11695	COG0708	Exodeoxyribonuclease III
H681_11705	COG0729	surface antigen
H681_11710	COG2911	Protein conserved in bacteria
H681_11750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H681_11765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H681_11915	COG0656	L-ascorbic acid biosynthetic process
H681_11925	COG3501	Rhs element vgr protein
H681_11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_11980	COG0174	glutamine synthetase
H681_12030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H681_12040	COG0640	Transcriptional regulator
H681_12045	COG2070	2-Nitropropane dioxygenase
H681_12050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H681_12075	COG1960	acyl-CoA dehydrogenase activity
H681_12085	COG2197	response regulator
H681_12100	COG2067	long-chain fatty acid transport protein
H681_12120	COG2197	response regulator
H681_12135	COG0714	Associated with various cellular activities
H681_12170	COG3119	arylsulfatase activity
H681_12180	COG0628	permease
H681_12190	COG2995	paraquat-inducible protein a
H681_12195	COG3008	intermembrane lipid transfer
H681_12215	COG0318	PFAM AMP-dependent synthetase and ligase
H681_12220	COG3119	arylsulfatase activity
H681_12235	COG2197	response regulator
H681_12245	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H681_12250	COG1960	acyl-CoA dehydrogenase activity
H681_12255	COG2079	MmgE PrpD family protein
H681_12265	COG2301	Belongs to the HpcH HpaI aldolase family
H681_12275	COG1960	acyl-CoA dehydrogenase activity
H681_12280	COG1960	acyl-CoA dehydrogenase activity
H681_12285	COG1024	Enoyl-CoA hydratase
H681_12300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H681_12310	COG0318	PFAM AMP-dependent synthetase and ligase
H681_12330	COG1028	Short-chain dehydrogenase reductase Sdr
H681_12335	COG1960	acyl-CoA dehydrogenase activity
H681_12340	COG1024	Enoyl-CoA hydratase
H681_12345	COG1012	belongs to the aldehyde dehydrogenase family
H681_12370	COG0183	Belongs to the thiolase family
H681_12375	COG1960	acyl-CoA dehydrogenase activity
H681_12380	COG1960	acyl-CoA dehydrogenase activity
H681_12455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H681_12560	COG1335	isochorismatase
H681_12575	COG0583	DNA-binding transcription factor activity
H681_12580	COG1335	isochorismatase
H681_12585	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H681_12590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H681_12595	COG0579	oxidoreductase
H681_12630	COG1595	DNA-templated transcription, initiation
H681_12635	COG3712	iron ion homeostasis
H681_12670	COG1960	acyl-CoA dehydrogenase activity
H681_12700	COG0583	DNA-binding transcription factor activity
H681_12710	COG4447	cellulose binding
H681_12730	COG2207	Transcriptional regulator
H681_12755	COG3246	L-lysine catabolic process to acetate
H681_12760	COG2175	clavaminate synthase activity
H681_12780	COG1131	(ABC) transporter
H681_12785	COG0842	Transport permease protein
H681_12790	COG0842	Transport permease protein
H681_12805	COG4319	ketosteroid isomerase
H681_12850	COG0583	DNA-binding transcription factor activity
H681_12855	COG0019	diaminopimelate decarboxylase activity
H681_12890	COG1191	sigma factor activity
H681_12895	COG2207	Transcriptional regulator
H681_12900	COG0697	spore germination
H681_12915	COG0477	Major facilitator Superfamily
H681_12920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H681_12935	COG1028	Short-chain dehydrogenase reductase Sdr
H681_12945	COG0668	transmembrane transport
H681_12975	COG0402	S-adenosylhomocysteine deaminase activity
H681_12985	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H681_13030	COG2837	iron assimilation
H681_13055	COG1595	DNA-templated transcription, initiation
H681_13070	COG4774	siderophore transport
H681_13085	COG2031	fatty acid transporter
H681_13095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H681_13100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H681_13110	COG1414	Transcriptional regulator
H681_13115	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H681_13125	COG1609	Transcriptional regulator
H681_13130	COG3265	gluconokinase activity
H681_13155	COG1288	antiporter activity
H681_13190	COG3038	cytochrome b561
H681_13195	COG0753	catalase activity
H681_13210	COG0252	asparaginase activity
H681_13215	COG1115	amino acid carrier protein
H681_13235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H681_13255	COG2194	sulfuric ester hydrolase activity
H681_13285	COG0488	(ABC) transporter
H681_13295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H681_13300	COG0583	DNA-binding transcription factor activity
H681_13305	COG1278	Cold shock
H681_13310	COG1968	undecaprenyl-diphosphatase activity
H681_13325	COG0583	DNA-binding transcription factor activity
H681_13335	COG0210	DNA helicase
H681_13340	COG1120	ATPase activity
H681_13345	COG2814	Major facilitator Superfamily
H681_13350	COG0656	L-ascorbic acid biosynthetic process
H681_13355	COG0583	DNA-binding transcription factor activity
H681_13360	COG1289	transmembrane transporter activity
H681_13370	COG1566	PFAM secretion protein HlyD family protein
H681_13385	COG4566	intracellular signal transduction
H681_13390	COG4191	Histidine kinase
H681_13400	COG1960	acyl-CoA dehydrogenase activity
H681_13415	COG0235	Class ii aldolase
H681_13420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_13425	COG0217	transcriptional regulatory protein
H681_13430	COG0583	DNA-binding transcription factor activity
H681_13445	COG3781	membrane
H681_13450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H681_13470	COG2356	endonuclease I
H681_13480	COG1522	sequence-specific DNA binding
H681_13510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H681_13520	COG2197	response regulator
H681_13550	COG2197	response regulator
H681_13555	COG2205	protein histidine kinase activity
H681_13555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_13600	COG2168	tRNA wobble position uridine thiolation
H681_13610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H681_13615	COG0435	Glutathione S-transferase
H681_13635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H681_13650	COG0492	ferredoxin-NADP+ reductase activity
H681_13665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H681_13670	COG0542	response to heat
H681_13675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H681_13680	COG1278	Cold shock
H681_13705	COG0482	sulfurtransferase activity
H681_13720	COG2850	peptidyl-arginine hydroxylation
H681_13725	COG2153	protein acetylation
H681_13780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H681_13795	COG0713	ATP synthesis coupled electron transport
H681_13820	COG2056	Na+-H+ antiporter family
H681_13825	COG0840	transmembrane signaling receptor activity
H681_13830	COG2205	protein histidine kinase activity
H681_13835	COG0745	RESPONSE REGULATOR receiver
H681_13870	COG3604	Transcriptional regulator
H681_13875	COG0720	synthase
H681_13895	COG1741	Belongs to the pirin family
H681_13970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H681_13975	COG1053	succinate dehydrogenase
H681_13980	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H681_13985	COG2009	succinate dehydrogenase
H681_14010	COG2084	Dehydrogenase
H681_14045	COG3795	YCII-related domain
H681_14050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H681_14055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H681_14105	COG4991	sh3 domain protein
H681_14130	COG0583	DNA-binding transcription factor activity
H681_14140	COG0826	peptidase U32
H681_14150	COG2808	Putative FMN-binding domain
H681_14155	COG2203	Gaf domain
H681_14155	COG3706	GGDEF domain
H681_14155	COG4251	negative regulation of phosphorylation
H681_14155	COG5001	Diguanylate cyclase
H681_14160	COG2957	Belongs to the agmatine deiminase family
H681_14180	COG0583	DNA-binding transcription factor activity
H681_14195	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H681_14200	COG3387	PFAM Glycoside hydrolase 15-related
H681_14205	COG1877	trehalose-phosphatase activity
H681_14220	COG5001	Diguanylate cyclase
H681_14220	COG3300	MHYT domain
H681_14240	COG3047	cAMP biosynthetic process
H681_14240	COG2885	chlorophyll binding
H681_14250	COG1064	alcohol dehydrogenase
H681_14255	COG0667	Aldo Keto reductase
H681_14260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H681_14265	COG0667	Aldo Keto reductase
H681_14275	COG2258	MOSC domain
H681_14280	COG2223	nitrite transmembrane transporter activity
H681_14285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H681_14290	COG1140	nitrate reductase beta subunit
H681_14295	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H681_14300	COG2181	nitrate reductase activity
H681_14305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H681_14310	COG0697	spore germination
H681_14315	COG0583	DNA-binding transcription factor activity
H681_14330	COG3278	Belongs to the heme-copper respiratory oxidase family
H681_14340	COG0517	IMP dehydrogenase activity
H681_14360	COG0583	DNA-binding transcription factor activity
H681_14365	COG1028	Short-chain dehydrogenase reductase Sdr
H681_14370	COG1942	4-Oxalocrotonate Tautomerase
H681_14375	COG2814	Major facilitator Superfamily
H681_14390	COG0659	secondary active sulfate transmembrane transporter activity
H681_14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_14405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H681_14435	COG1285	pathogenesis
H681_14455	COG2318	DinB family
H681_14465	COG0154	amidase activity
H681_14490	COG4638	Rieske (2fe-2S)
H681_14495	COG0583	DNA-binding transcription factor activity
H681_14510	COG2271	Major facilitator Superfamily
H681_14535	COG0583	DNA-binding transcription factor activity
H681_14540	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H681_14545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H681_14565	COG0583	DNA-binding transcription factor activity
H681_14595	COG2207	Transcriptional regulator
H681_14610	COG2207	Transcriptional regulator
H681_14620	COG4106	trans-aconitate 2-methyltransferase activity
H681_14675	COG0583	DNA-binding transcription factor activity
H681_14680	COG1028	Short-chain dehydrogenase reductase Sdr
H681_14700	COG0583	DNA-binding transcription factor activity
H681_14705	COG0778	Nitroreductase
H681_14725	COG0641	radical SAM
H681_14765	COG3008	intermembrane lipid transfer
H681_14770	COG2995	paraquat-inducible protein a
H681_14790	COG2067	long-chain fatty acid transport protein
H681_14800	COG0583	DNA-binding transcription factor activity
H681_14805	COG1024	Enoyl-CoA hydratase
H681_14825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H681_14915	COG3501	Rhs element vgr protein
H681_14940	COG3706	GGDEF domain
H681_14945	COG1335	isochorismatase
H681_14950	COG1335	isochorismatase
H681_14960	COG0583	DNA-binding transcription factor activity
H681_14970	COG0318	PFAM AMP-dependent synthetase and ligase
H681_14980	COG4221	oxidoreductase activity
H681_14985	COG0745	RESPONSE REGULATOR receiver
H681_14990	COG0642	Histidine kinase
H681_15015	COG5001	Diguanylate cyclase
H681_15015	COG4251	negative regulation of phosphorylation
H681_15015	COG3706	GGDEF domain
H681_15015	COG2203	Gaf domain
H681_15045	COG0640	Transcriptional regulator
H681_15065	COG0174	glutamine synthetase
H681_15070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_15075	COG0583	DNA-binding transcription factor activity
H681_15080	COG3842	ATPase activity
H681_15090	COG1176	ABC-type spermidine putrescine transport system, permease component I
H681_15095	COG1177	transmembrane transport
H681_15130	COG3278	Belongs to the heme-copper respiratory oxidase family
H681_15150	COG3278	Belongs to the heme-copper respiratory oxidase family
H681_15165	COG2010	Cytochrome c
H681_15205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H681_15255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H681_15260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H681_15270	COG2963	transposase activity
H681_15275	COG2801	Transposase and inactivated derivatives
H681_15345	COG0402	S-adenosylhomocysteine deaminase activity
H681_15370	COG2186	Transcriptional regulator
H681_15375	COG0579	oxidoreductase
H681_15390	COG2252	PERMEase
H681_15395	COG2197	response regulator
H681_15400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_15400	COG2205	protein histidine kinase activity
H681_15430	COG2233	PERMEase
H681_15435	COG0840	transmembrane signaling receptor activity
H681_15455	COG0745	RESPONSE REGULATOR receiver
H681_15460	COG2853	Lipoprotein
H681_15495	COG2132	Multicopper oxidase
H681_15515	COG0842	Transport permease protein
H681_15520	COG1131	(ABC) transporter
H681_15525	COG0625	glutathione transferase activity
H681_15535	COG1960	acyl-CoA dehydrogenase activity
H681_15555	COG2197	response regulator
H681_15580	COG0625	glutathione transferase activity
H681_15585	COG1956	GAF domain-containing protein
H681_15595	COG0784	Response regulator, receiver
H681_15595	COG5002	protein histidine kinase activity
H681_15595	COG2205	protein histidine kinase activity
H681_15600	COG1846	Transcriptional regulator
H681_15605	COG0386	Belongs to the glutathione peroxidase family
H681_15615	COG0436	Aminotransferase
H681_15635	COG3384	dioxygenase
H681_15650	COG1024	Enoyl-CoA hydratase
H681_15675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H681_15680	COG3214	Protein conserved in bacteria
H681_15695	COG0583	DNA-binding transcription factor activity
H681_15700	COG1846	Transcriptional regulator
H681_15705	COG1764	response to oxidative stress
H681_15740	COG4181	ATPase activity
H681_15745	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H681_15760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H681_15765	COG0583	DNA-binding transcription factor activity
H681_15770	COG2855	membrane
H681_15775	COG2259	Doxx family
H681_15780	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H681_15785	COG0084	hydrolase, TatD family'
H681_15805	COG3706	GGDEF domain
H681_15805	COG0745	RESPONSE REGULATOR receiver
H681_15830	COG0714	Associated with various cellular activities
H681_15835	COG0583	DNA-binding transcription factor activity
H681_15860	COG1309	transcriptional regulator
H681_15875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H681_15880	COG1960	acyl-CoA dehydrogenase activity
H681_15885	COG1024	Enoyl-CoA hydratase
H681_15915	COG1595	DNA-templated transcription, initiation
H681_15920	COG2304	oxidoreductase activity
H681_15925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_15950	COG2267	carboxylic ester hydrolase activity
H681_15990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H681_16005	COG0084	hydrolase, TatD family'
H681_16025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H681_16035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H681_16060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H681_16065	COG1399	metal-binding, possibly nucleic acid-binding protein
H681_16075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H681_16075	COG0616	signal peptide processing
H681_16080	COG0546	phosphoglycolate phosphatase activity
H681_16090	COG1530	ribonuclease E activity
H681_16100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H681_16105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H681_16110	COG2835	tetraacyldisaccharide 4'-kinase activity
H681_16120	COG0848	biopolymer transport protein
H681_16125	COG0811	peptide transport
H681_16130	COG2333	competence protein COMEC
H681_16130	COG0658	competence protein
H681_16150	COG4591	ABC-type transport system involved in lipoprotein release permease component
H681_16165	COG0584	glycerophosphoryl diester phosphodiesterase
H681_16175	COG1477	protein flavinylation
H681_16180	COG1113	amino acid transport
H681_16190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H681_16200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H681_16215	COG1376	ErfK ybiS ycfS ynhG family protein
H681_16275	COG0589	response to stress
H681_16290	COG0741	lytic transglycosylase activity
H681_16300	COG3217	Mosc domain protein beta barrel domain protein
H681_16300	COG0633	Ferredoxin
H681_16315	COG1070	Carbohydrate kinase
H681_16335	COG0303	'Molybdopterin
H681_16340	COG0521	Mo-molybdopterin cofactor biosynthetic process
H681_16360	COG1309	transcriptional regulator
H681_16365	COG0625	glutathione transferase activity
H681_16375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H681_16385	COG0004	ammonium transporteR
H681_16405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H681_16415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_16415	COG2205	protein histidine kinase activity
H681_16420	COG2197	response regulator
H681_16435	COG3171	Protein conserved in bacteria
H681_16440	COG2027	D-alanyl-D-alanine carboxypeptidase
H681_16445	COG0745	RESPONSE REGULATOR receiver
H681_16445	COG3706	GGDEF domain
H681_16455	COG3130	regulation of translation
H681_16500	COG0579	oxidoreductase
H681_16525	COG0714	Associated with various cellular activities
H681_16580	COG0308	aminopeptidase N
H681_16590	COG3139	Protein of unknown function (DUF1315)
H681_16600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H681_16625	COG0446	pyridine nucleotide-disulphide oxidoreductase
H681_16625	COG1902	pentaerythritol trinitrate reductase activity
H681_16655	COG1286	toxin biosynthetic process
H681_16660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H681_16665	COG0285	dihydrofolate synthase activity
H681_16675	COG0135	phosphoribosylanthranilate isomerase activity
H681_16710	COG2226	methyltransferase
H681_16715	COG0066	3-isopropylmalate dehydratase activity
H681_16720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H681_16745	COG0251	oxidation-reduction process
H681_16750	COG3949	Membrane
H681_16760	COG1028	Short-chain dehydrogenase reductase Sdr
H681_16775	COG0800	Aldolase
H681_16780	COG0596	Alpha beta hydrolase
H681_16795	COG0583	DNA-binding transcription factor activity
H681_16820	COG1555	photosystem II stabilization
H681_16830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H681_16840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H681_16855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H681_16880	COG1132	(ABC) transporter
H681_16905	COG0676	glucose-6-phosphate 1-epimerase activity
H681_16935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H681_16940	COG3153	acetyltransferase
H681_16950	COG0180	Tryptophanyl-tRNA synthetase
H681_16955	COG0009	L-threonylcarbamoyladenylate synthase
H681_16960	COG0613	PHP domain protein
H681_16965	COG2917	probably involved in intracellular septation
H681_16970	COG2350	Protein conserved in bacteria
H681_16980	COG0745	RESPONSE REGULATOR receiver
H681_16985	COG3678	ATP-independent chaperone mediated protein folding
H681_17000	COG0778	Nitroreductase
H681_17005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H681_17020	COG1201	RNA secondary structure unwinding
H681_17040	COG2154	pterin-4-alpha-carbinolamine dehydratase
H681_17090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H681_17105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H681_17135	COG0402	S-adenosylhomocysteine deaminase activity
H681_17140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H681_17150	COG1028	Short-chain dehydrogenase reductase Sdr
H681_17155	COG3706	GGDEF domain
H681_17170	COG3278	Belongs to the heme-copper respiratory oxidase family
H681_17205	COG2207	Transcriptional regulator
H681_17210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H681_17230	COG1752	Esterase of the alpha-beta hydrolase superfamily
H681_17240	COG1846	Transcriptional regulator
H681_17250	COG3706	GGDEF domain
H681_17250	COG5001	Diguanylate cyclase
H681_17250	COG4251	negative regulation of phosphorylation
H681_17250	COG2203	Gaf domain
H681_17255	COG0514	ATP-dependent DNA helicase (RecQ)
H681_17265	COG2832	Protein of unknown function (DUF454)
H681_17285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_17295	COG3300	MHYT domain
H681_17295	COG5001	Diguanylate cyclase
H681_17320	COG0367	asparagine synthase
H681_17330	COG1363	Peptidase, m42
H681_17370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H681_17375	COG3162	membrane
H681_17415	COG2853	Lipoprotein
H681_17430	COG1560	Kdo2-lipid A biosynthetic process
H681_17440	COG2894	cell division
H681_17495	COG0560	Phosphoserine phosphatase
H681_17500	COG0750	zinc metalloprotease
H681_17515	COG2200	EAL domain
H681_17540	COG3339	Conserved Protein
H681_17545	COG0545	Peptidyl-prolyl cis-trans isomerase
H681_17555	COG0385	Bile acid
H681_17560	COG2076	Multidrug Resistance protein
H681_17570	COG0477	Major facilitator Superfamily
H681_17575	COG4772	TonB-dependent receptor
H681_17590	COG2205	protein histidine kinase activity
H681_17625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_17650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H681_17670	COG0179	Fumarylacetoacetate (FAA) hydrolase
H681_17680	COG0778	Nitroreductase
H681_17710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H681_17715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H681_17730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H681_17740	COG0425	Belongs to the sulfur carrier protein TusA family
H681_17745	COG4783	chaperone-mediated protein folding
H681_17760	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H681_17765	COG0602	queuosine metabolic process
H681_17770	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H681_17800	COG0824	Thioesterase
H681_17835	COG0783	Belongs to the Dps family
H681_17920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H681_17935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H681_17965	COG1960	acyl-CoA dehydrogenase activity
H681_18005	COG0778	Nitroreductase
H681_18010	COG1797	cobyrinic acid a,c-diamide synthase activity
H681_18020	COG4206	TonB-dependent receptor
H681_18025	COG1289	transmembrane transporter activity
H681_18030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H681_18035	COG1127	ABC transporter
H681_18095	COG0791	NLP P60 protein
H681_18100	COG0791	NLP P60 protein
H681_18135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H681_18140	COG1960	acyl-CoA dehydrogenase activity
H681_18165	COG1595	DNA-templated transcription, initiation
H681_18180	COG3706	GGDEF domain
H681_18190	COG0537	adenosine 5'-monophosphoramidase activity
H681_18195	COG0625	glutathione transferase activity
H681_18200	COG1643	Atp-dependent helicase
H681_18210	COG0318	PFAM AMP-dependent synthetase and ligase
H681_18215	COG2841	Protein conserved in bacteria
H681_18220	COG0318	PFAM AMP-dependent synthetase and ligase
H681_18225	COG2267	carboxylic ester hydrolase activity
H681_18230	COG2030	dehydratase
H681_18235	COG2814	Major facilitator Superfamily
H681_18280	COG0589	response to stress
H681_18285	COG2194	sulfuric ester hydrolase activity
H681_18295	COG3622	Belongs to the hyi family
H681_18300	COG2084	Dehydrogenase
H681_18305	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
H681_18315	COG3639	organic phosphonate transmembrane transporter activity
H681_18365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_18370	COG1309	transcriptional regulator
H681_18385	COG1801	Protein of unknown function DUF72
H681_18395	COG1214	PFAM Peptidase M22, glycoprotease
H681_18400	COG0563	adenylate kinase activity
H681_18415	COG0789	Transcriptional regulator
H681_18435	COG1073	alpha beta
H681_18465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H681_18470	COG3706	GGDEF domain
H681_18470	COG4251	negative regulation of phosphorylation
H681_18470	COG2203	Gaf domain
H681_18470	COG5001	Diguanylate cyclase
H681_18500	COG0840	transmembrane signaling receptor activity
H681_18505	COG1238	metal cluster binding
H681_18520	COG0477	Major facilitator Superfamily
H681_18540	COG4574	serine-type endopeptidase inhibitor activity
H681_18555	COG1012	belongs to the aldehyde dehydrogenase family
H681_18560	COG1063	alcohol dehydrogenase
H681_18570	COG1902	pentaerythritol trinitrate reductase activity
H681_18580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H681_18595	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H681_18605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H681_18610	COG4681	YaeQ
H681_18615	COG3706	GGDEF domain
H681_18620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H681_18660	COG1607	acyl-coa hydrolase
H681_18675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H681_18680	COG0228	four-way junction DNA binding
H681_18685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H681_18695	COG4536	flavin adenine dinucleotide binding
H681_18700	COG0477	Major facilitator Superfamily
H681_18725	COG0494	nUDIX hydrolase
H681_18760	COG0590	tRNA wobble adenosine to inosine editing
H681_18765	COG2132	Multicopper oxidase
H681_18780	COG1570	exodeoxyribonuclease VII activity
H681_18790	COG0739	heme binding
H681_18825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H681_18840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H681_18845	COG0667	Aldo Keto reductase
H681_18855	COG0436	Aminotransferase
H681_18925	COG0316	Belongs to the HesB IscA family
H681_18945	COG1045	serine acetyltransferase
H681_18960	COG3134	Outer membrane lipoprotein
H681_18975	COG1862	Preprotein translocase
H681_18990	COG4969	Belongs to the N-Me-Phe pilin family
H681_19020	COG2200	EAL domain
H681_19030	COG0795	lipopolysaccharide-transporting ATPase activity
H681_19035	COG0795	lipopolysaccharide-transporting ATPase activity
H681_19065	COG0028	Belongs to the TPP enzyme family
H681_19070	COG0490	domain, Protein
H681_19070	COG0471	metal ion transport
H681_19085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H681_19095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H681_19100	COG0339	signal peptide processing
H681_19105	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H681_19110	COG0783	Belongs to the Dps family
H681_19130	COG0419	ATPase involved in DNA repair
H681_19135	COG0420	3'-5' exonuclease activity
H681_19185	COG1126	abc transporter atp-binding protein
H681_19190	COG0765	amino acid transport
H681_19195	COG4597	amino acid ABC transporter
H681_19200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_19205	COG0400	carboxylic ester hydrolase activity
H681_19210	COG1648	precorrin-2 dehydrogenase activity
H681_19210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H681_19240	COG2863	cytochrome
H681_19245	COG2010	Cytochrome c
H681_19255	COG0318	PFAM AMP-dependent synthetase and ligase
H681_19260	COG3706	GGDEF domain
H681_19290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_19305	COG2181	nitrate reductase activity
H681_19310	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H681_19315	COG1140	nitrate reductase beta subunit
H681_19320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H681_19325	COG2223	nitrite transmembrane transporter activity
H681_19335	COG3850	Histidine kinase
H681_19340	COG2197	response regulator
H681_19365	COG0303	'Molybdopterin
H681_19370	COG0521	Mo-molybdopterin cofactor biosynthetic process
H681_19385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H681_19395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H681_19410	COG0477	Major facilitator Superfamily
H681_19415	COG0583	DNA-binding transcription factor activity
H681_19420	COG3022	response to hydroperoxide
H681_19490	COG0300	oxidoreductase activity
H681_19510	COG1566	PFAM secretion protein HlyD family protein
H681_19530	COG0583	DNA-binding transcription factor activity
H681_19535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H681_19545	COG0697	spore germination
H681_19570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_19575	COG0697	spore germination
H681_19580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H681_19585	COG1028	Short-chain dehydrogenase reductase Sdr
H681_19605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_19665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_19675	COG0251	oxidation-reduction process
H681_19690	COG1231	oxidoreductase activity
H681_19710	COG1231	oxidoreductase activity
H681_19715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_19720	COG4221	oxidoreductase activity
H681_19720	COG3321	synthase
H681_19720	COG0300	oxidoreductase activity
H681_19720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H681_19745	COG4977	sequence-specific DNA binding
H681_19745	COG1917	Cupin 2, conserved barrel domain protein
H681_19750	COG0183	Belongs to the thiolase family
H681_19765	COG4447	cellulose binding
H681_19795	COG1028	Short-chain dehydrogenase reductase Sdr
H681_19800	COG1250	3-hydroxyacyl-CoA dehydrogenase
H681_19800	COG1024	Enoyl-CoA hydratase
H681_19825	COG1960	acyl-CoA dehydrogenase activity
H681_19830	COG0483	inositol monophosphate 1-phosphatase activity
H681_19870	COG2197	response regulator
H681_19905	COG1028	Short-chain dehydrogenase reductase Sdr
H681_19915	COG0596	Alpha beta hydrolase
H681_19930	COG1346	cytolysis
H681_19935	COG1380	Effector of murein hydrolase LrgA
H681_19940	COG0583	DNA-binding transcription factor activity
H681_19965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H681_19980	COG0492	ferredoxin-NADP+ reductase activity
H681_19985	COG5001	Diguanylate cyclase
H681_20000	COG1307	EDD domain protein, DegV family
H681_20010	COG1309	transcriptional regulator
H681_20015	COG0778	Nitroreductase
H681_20020	COG0386	Belongs to the glutathione peroxidase family
H681_20045	COG0204	Acyl-transferase
H681_20050	COG2885	chlorophyll binding
H681_20055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H681_20100	COG0318	PFAM AMP-dependent synthetase and ligase
H681_20105	COG0183	Belongs to the thiolase family
H681_20120	COG1280	lysine exporter protein (LysE YggA)
H681_20125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H681_20140	COG0833	amino acid
H681_20145	COG2119	membrane
H681_20160	COG0501	Belongs to the peptidase M48B family
H681_20165	COG0840	transmembrane signaling receptor activity
H681_20170	COG2135	peptidase activity
H681_20250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H681_20270	COG0788	formyltetrahydrofolate deformylase activity
H681_20280	COG2925	Exonuclease
H681_20310	COG0714	Associated with various cellular activities
H681_20340	COG0589	response to stress
H681_20350	COG1024	Enoyl-CoA hydratase
H681_20360	COG3706	GGDEF domain
H681_20375	COG0693	protein deglycase activity
H681_20395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H681_20405	COG0583	DNA-binding transcription factor activity
H681_20410	COG0477	Major facilitator Superfamily
H681_20430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H681_20430	COG0426	domain, Protein
H681_20450	COG0589	response to stress
H681_20455	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H681_20465	COG2814	Major facilitator Superfamily
H681_20470	COG1902	pentaerythritol trinitrate reductase activity
H681_20485	COG1918	ferrous iron import across plasma membrane
H681_20500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H681_20555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H681_20560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H681_20575	COG1090	epimerase
H681_20580	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
H681_20590	COG0789	Transcriptional regulator
H681_20595	COG0415	Belongs to the DNA photolyase family
H681_20605	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
H681_20620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H681_20625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H681_20655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H681_20685	COG3549	Plasmid maintenance system killer
H681_20690	COG4974	Belongs to the 'phage' integrase family
H681_20755	COG1487	ribonuclease activity
H681_20765	COG0473	3-isopropylmalate dehydrogenase activity
H681_20770	COG0288	reversible hydration of carbon dioxide
H681_20785	COG0456	acetyltransferase
H681_20830	COG3008	intermembrane lipid transfer
H681_20835	COG2995	paraquat-inducible protein a
H681_20840	COG2995	paraquat-inducible protein a
H681_20845	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H681_20850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H681_20855	COG1183	phosphatidylcholine synthase activity
H681_20860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H681_20870	COG0028	Belongs to the TPP enzyme family
H681_20880	COG3098	single-species biofilm formation
H681_20890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H681_20920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H681_20940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H681_20955	COG4191	Histidine kinase
H681_21045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H681_21055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H681_21065	COG0195	Participates in both transcription termination and antitermination
H681_21090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H681_21095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H681_21100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H681_21155	COG0497	DNA recombination
H681_21165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H681_21185	COG2186	Transcriptional regulator
H681_21190	COG1620	l-lactate permease
H681_21195	COG1304	FMN binding
H681_21205	COG0745	RESPONSE REGULATOR receiver
H681_21210	COG0642	Histidine kinase
H681_21220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H681_21245	COG0529	Catalyzes the synthesis of activated sulfate
H681_21250	COG3842	ATPase activity
H681_21260	COG0523	cobalamin synthesis protein
H681_21265	COG2879	small protein
H681_21270	COG1966	Carbon starvation protein
H681_21305	COG1253	flavin adenine dinucleotide binding
H681_21330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H681_21335	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H681_21335	COG3608	succinylglutamate desuccinylase aspartoacylase
H681_21340	COG2010	Cytochrome c
H681_21355	COG2814	Major facilitator Superfamily
H681_21365	COG1294	oxidase, subunit
H681_21370	COG1271	oxidase subunit
H681_21390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H681_21395	COG1297	OPT oligopeptide transporter protein
H681_21400	COG0697	spore germination
H681_21405	COG1522	sequence-specific DNA binding
H681_21410	COG0183	Belongs to the thiolase family
H681_21415	COG1028	Short-chain dehydrogenase reductase Sdr
H681_21440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H681_21465	COG0509	glycine decarboxylation via glycine cleavage system
H681_21470	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H681_21505	COG4974	Belongs to the 'phage' integrase family
H681_21510	COG3609	addiction module antidote protein, CC2985 family
H681_21520	COG3276	selenocysteine insertion sequence binding
H681_21535	COG2864	formate dehydrogenase
H681_21540	COG0437	4 iron, 4 sulfur cluster binding
H681_21545	COG3383	formate dehydrogenase (NAD+) activity
H681_21545	COG0243	molybdopterin cofactor binding
H681_21550	COG0243	molybdopterin cofactor binding
H681_21550	COG3383	formate dehydrogenase (NAD+) activity
H681_21555	COG1902	pentaerythritol trinitrate reductase activity
H681_21555	COG0446	pyridine nucleotide-disulphide oxidoreductase
H681_21570	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H681_21580	COG0534	Mate efflux family protein
H681_21600	COG1090	epimerase
H681_21605	COG0431	NADPH-dependent FMN reductase
H681_21610	COG0789	Transcriptional regulator
H681_21615	COG0484	heat shock protein binding
H681_21625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H681_21625	COG1328	CTP reductase activity
H681_21645	COG0023	Translation Initiation Factor
H681_21660	COG3706	GGDEF domain
H681_21660	COG0745	RESPONSE REGULATOR receiver
H681_21670	COG0010	Belongs to the arginase family
H681_21675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_21740	COG2095	MarC family integral membrane protein
H681_21745	COG0683	leucine binding
H681_21750	COG0559	Belongs to the binding-protein-dependent transport system permease family
H681_21760	COG0411	ABC transporter
H681_21780	COG0831	urea catabolic process
H681_21790	COG0832	Belongs to the urease beta subunit family
H681_21800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H681_21815	COG0443	Heat shock 70 kDa protein
H681_21840	COG2982	Protein involved in outer membrane biogenesis
H681_21890	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H681_21920	COG2814	Major facilitator Superfamily
H681_21935	COG2814	Major facilitator Superfamily
H681_21955	COG4221	oxidoreductase activity
H681_21965	COG0410	ABC transporter
H681_21980	COG0559	Belongs to the binding-protein-dependent transport system permease family
H681_21990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_21995	COG1012	belongs to the aldehyde dehydrogenase family
H681_22000	COG0583	DNA-binding transcription factor activity
H681_22005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H681_22010	COG1272	protein, Hemolysin III
H681_22025	COG4968	Prepilin-type N-terminal cleavage methylation domain
H681_22050	COG0668	transmembrane transport
H681_22070	COG3300	MHYT domain
H681_22070	COG5001	Diguanylate cyclase
H681_22080	COG0305	Participates in initiation and elongation during chromosome replication
H681_22100	COG0360	Binds together with S18 to 16S ribosomal RNA
H681_22110	COG0557	exoribonuclease II activity
H681_22130	COG0330	HflC and HflK could
H681_22135	COG0330	HflC and HflK could
H681_22140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H681_22165	COG0802	atpase or kinase
H681_22170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H681_22170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H681_22225	COG5002	protein histidine kinase activity
H681_22225	COG5001	Diguanylate cyclase
H681_22230	COG3830	Belongs to the UPF0237 family
H681_22230	COG0560	Phosphoserine phosphatase
H681_22240	COG1988	membrane-bound metal-dependent
H681_22265	COG3577	Aspartyl protease
H681_22280	COG3150	esterase
H681_22285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H681_22295	COG0494	nUDIX hydrolase
H681_22315	COG1538	Outer membrane efflux protein
H681_22320	COG0235	Class ii aldolase
H681_22335	COG1902	pentaerythritol trinitrate reductase activity
H681_22335	COG0446	pyridine nucleotide-disulphide oxidoreductase
H681_22345	COG1519	Transferase
H681_22365	COG0667	Aldo Keto reductase
H681_22380	COG1960	acyl-CoA dehydrogenase activity
H681_22405	COG1132	(ABC) transporter
H681_22420	COG0463	Glycosyl transferase, family 2
H681_22440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H681_22445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H681_22450	COG0438	transferase activity, transferring glycosyl groups
H681_22455	COG2192	nodulation
H681_22480	COG0438	transferase activity, transferring glycosyl groups
H681_22490	COG0859	PFAM glycosyl transferase family 9
H681_22515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H681_22520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H681_22525	COG1960	acyl-CoA dehydrogenase activity
H681_22535	COG1196	nuclear chromosome segregation
H681_22535	COG3264	Mechanosensitive ion channel
H681_22545	COG2873	o-acetylhomoserine
H681_22550	COG3118	belongs to the thioredoxin family
H681_22565	COG1192	Involved in chromosome partitioning
H681_22570	COG0583	DNA-binding transcription factor activity
H681_22575	COG2814	Major facilitator Superfamily
H681_22590	COG0493	'glutamate synthase
H681_22595	COG0069	glutamate synthase activity
H681_22595	COG0067	glutamate synthase
H681_22595	COG0070	glutamate synthase
H681_22635	COG0443	Heat shock 70 kDa protein
H681_22650	COG1451	nucleotide metabolic process
H681_22675	COG0126	phosphoglycerate kinase activity
H681_22680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H681_22700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H681_22705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H681_22745	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H681_22760	COG4521	taurine ABC transporter
H681_22770	COG0583	DNA-binding transcription factor activity
H681_22775	COG1960	acyl-CoA dehydrogenase activity
H681_22785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H681_22790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H681_22795	COG0513	Belongs to the DEAD box helicase family
H681_22800	COG1126	abc transporter atp-binding protein
H681_22805	COG0765	amino acid transport
H681_22825	COG1490	D-aminoacyl-tRNA deacylase activity
H681_22845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_22850	COG0251	oxidation-reduction process
H681_22875	COG2986	histidine ammonia-lyase
H681_22885	COG4176	ABC-type proline glycine betaine transport system permease component
H681_22895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H681_22900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H681_22905	COG2986	histidine ammonia-lyase
H681_22920	COG0402	S-adenosylhomocysteine deaminase activity
H681_22970	COG0668	transmembrane transport
H681_22985	COG3852	Histidine kinase
H681_22995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H681_23015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H681_23025	COG4942	peptidase
H681_23030	COG0793	Belongs to the peptidase S41A family
H681_23035	COG2861	carbohydrate metabolic process
H681_23050	COG0107	imidazoleglycerol-phosphate synthase activity
H681_23085	COG1194	a g-specific adenine glycosylase
H681_23090	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H681_23145	COG2801	Transposase and inactivated derivatives
H681_23150	COG2963	transposase activity
H681_23165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H681_23195	COG1566	PFAM secretion protein HlyD family protein
H681_23200	COG2814	Major facilitator Superfamily
H681_23260	COG1215	transferase activity, transferring glycosyl groups
H681_23270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H681_23285	COG1088	dTDP-glucose 4,6-dehydratase activity
H681_23290	COG1091	dTDP-4-dehydrorhamnose reductase activity
H681_23345	COG0693	protein deglycase activity
H681_23370	COG2233	PERMEase
H681_23380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H681_23405	COG1960	acyl-CoA dehydrogenase activity
H681_23420	COG0778	Nitroreductase
H681_23450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H681_23455	COG4067	protein conserved in archaea
H681_23455	COG0189	ligase activity
H681_23475	COG0745	RESPONSE REGULATOR receiver
H681_23480	COG2183	response to ionizing radiation
H681_23500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H681_23515	COG0330	HflC and HflK could
H681_23530	COG0730	response to heat
H681_23540	COG3706	GGDEF domain
H681_23545	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
H681_23550	COG0494	nUDIX hydrolase
H681_23575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H681_23590	COG2234	aminopeptidase activity
H681_23605	COG3842	ATPase activity
H681_23610	COG1176	ABC-type spermidine putrescine transport system, permease component I
H681_23615	COG1177	transmembrane transport
H681_23620	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_23625	COG0531	amino acid
H681_23635	COG3111	PFAM Bacterial OB fold (BOF) protein
H681_23645	COG0179	Fumarylacetoacetate (FAA) hydrolase
H681_23650	COG0277	FAD linked oxidase domain protein
H681_23655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H681_23665	COG1683	Conserved Protein
H681_23710	COG1177	transmembrane transport
H681_23715	COG1176	ABC-type spermidine putrescine transport system, permease component I
H681_23720	COG3842	ATPase activity
H681_23740	COG0174	glutamine synthetase
H681_23745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H681_23750	COG0174	glutamine synthetase
H681_23755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_23780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H681_23825	COG1215	transferase activity, transferring glycosyl groups
H681_23845	COG3706	GGDEF domain
H681_23865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H681_23875	COG4208	sulfate ABC transporter
H681_23885	COG1309	transcriptional regulator
H681_23890	COG4221	oxidoreductase activity
H681_23915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H681_23950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H681_24005	COG0432	Pfam Uncharacterised protein family UPF0047
H681_24010	COG0004	ammonium transporteR
H681_24015	COG0347	Belongs to the P(II) protein family
H681_24025	COG0606	chelatase, subunit chli
H681_24035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H681_24040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H681_24045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H681_24050	COG3209	COG3209 Rhs family protein
H681_24065	COG0583	DNA-binding transcription factor activity
H681_24095	COG1917	Cupin 2, conserved barrel domain protein
H681_24095	COG1396	sequence-specific DNA binding
H681_24130	COG1522	sequence-specific DNA binding
H681_24135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H681_24140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H681_24145	COG2814	Major facilitator Superfamily
H681_24150	COG1012	belongs to the aldehyde dehydrogenase family
H681_24170	COG0747	negative chemotaxis
H681_24180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H681_24185	COG0756	dUTP diphosphatase activity
H681_24215	COG0708	Exodeoxyribonuclease III
H681_24230	COG1561	YicC-like family, N-terminal region
H681_24245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H681_24265	COG2207	Transcriptional regulator
H681_24265	COG1917	Cupin 2, conserved barrel domain protein
H681_24275	COG0583	DNA-binding transcription factor activity
H681_24280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H681_24340	COG1253	flavin adenine dinucleotide binding
H681_24345	COG0739	heme binding
H681_24365	COG0581	inorganic phosphate transmembrane transporter activity
H681_24385	COG1607	acyl-coa hydrolase
H681_24405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H681_24420	COG2391	methyltransferase activity
H681_24440	COG0676	glucose-6-phosphate 1-epimerase activity
H681_24470	COG0583	DNA-binding transcription factor activity
H681_24495	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H681_24500	COG2181	nitrate reductase activity
H681_24500	COG0247	lactate metabolic process
H681_24505	COG1902	pentaerythritol trinitrate reductase activity
H681_24505	COG0446	pyridine nucleotide-disulphide oxidoreductase
H681_24525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H681_24525	COG1017	nitric oxide dioxygenase activity
H681_24535	COG0393	Putative heavy-metal-binding
H681_24605	COG1960	acyl-CoA dehydrogenase activity
H681_24610	COG1960	acyl-CoA dehydrogenase activity
H681_24620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H681_24635	COG1113	amino acid transport
H681_24640	COG1012	belongs to the aldehyde dehydrogenase family
H681_24645	COG0583	DNA-binding transcription factor activity
H681_24660	COG2824	Alkylphosphonate utilization operon protein PhnA
H681_24670	COG0511	ligase activity, forming carbon-carbon bonds
H681_24670	COG5016	pyruvate
H681_24675	COG0439	Biotin carboxylase
H681_24680	COG0583	DNA-binding transcription factor activity
H681_24695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H681_24725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H681_24730	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H681_24750	COG3256	nitric oxide reductase
H681_24755	COG2010	Cytochrome c
H681_24765	COG1845	cytochrome c oxidase, subunit III
H681_24820	COG0475	glutathione-regulated potassium exporter activity
H681_24845	COG1028	Short-chain dehydrogenase reductase Sdr
H681_24850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H681_24855	COG0174	glutamine synthetase
H681_24860	COG1028	Short-chain dehydrogenase reductase Sdr
H681_24865	COG1607	acyl-coa hydrolase
H681_24870	COG4651	solute:proton antiporter activity
H681_24870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H681_24895	COG4191	Histidine kinase
H681_24920	COG2249	NAD(P)H dehydrogenase (quinone) activity
H681_24940	COG1042	CoA-binding domain protein
H681_24940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H681_24940	COG0045	succinate-CoA ligase (ADP-forming) activity
H681_24945	COG1960	acyl-CoA dehydrogenase activity
H681_24950	COG1024	Enoyl-CoA hydratase
H681_24955	COG1396	sequence-specific DNA binding
H681_24960	COG0235	Class ii aldolase
H681_24965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H681_24970	COG0833	amino acid
H681_24995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H681_25005	COG2197	response regulator
H681_25010	COG0596	Alpha beta hydrolase
H681_25020	COG4176	ABC-type proline glycine betaine transport system permease component
H681_25030	COG1760	l-serine dehydratase
H681_25045	COG3657	addiction module killer protein
H681_25050	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H681_25085	COG3210	domain, Protein
H681_25085	COG3210	domain, Protein
H681_25090	COG2831	hemolysin activation secretion protein
H681_25110	COG0824	Thioesterase
H681_25110	COG1250	3-hydroxyacyl-CoA dehydrogenase
H681_25120	COG3246	L-lysine catabolic process to acetate
H681_25150	COG2851	Citrate transporter
H681_25155	COG0861	Integral membrane protein TerC family
H681_25205	COG0700	Nucleoside recognition
H681_25210	COG1301	dicarboxylic acid transport
H681_25250	COG5002	protein histidine kinase activity
H681_25255	COG3023	N-Acetylmuramoyl-L-alanine amidase
H681_25260	COG2095	MarC family integral membrane protein
H681_25265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H681_25310	COG3312	ion transport
H681_25315	COG1475	DNA binding
H681_25320	COG1192	Involved in chromosome partitioning
H681_25345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane