locus-tag	class	description
PspR84_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PspR84_00010	COG0592	DNA-directed DNA polymerase activity
PspR84_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PspR84_00020	COG0187	DNA topoisomerase II activity
PspR84_00050	COG0495	leucyl-tRNA aminoacylation
PspR84_00105	COG0751	glycine-tRNA ligase activity
PspR84_00110	COG0752	glycyl-tRNA synthetase alpha subunit
PspR84_00115	COG2818	Glycosylase
PspR84_00135	COG0569	domain protein
PspR84_00140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PspR84_00145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PspR84_00150	COG0242	peptide deformylase activity
PspR84_00160	COG0758	DNA mediated transformation
PspR84_00165	COG0009	L-threonylcarbamoyladenylate synthase
PspR84_00185	COG0156	8-amino-7-oxononanoate synthase activity
PspR84_00200	COG0408	coproporphyrinogen oxidase activity
PspR84_00205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PspR84_00220	COG3119	arylsulfatase activity
PspR84_00245	COG2851	Citrate transporter
PspR84_00250	COG0861	Integral membrane protein TerC family
PspR84_00260	COG1283	sodium-dependent phosphate transmembrane transporter activity
PspR84_00265	COG0612	Peptidase, M16
PspR84_00275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PspR84_00280	COG1127	ABC transporter
PspR84_00295	COG0700	Nucleoside recognition
PspR84_00300	COG1301	dicarboxylic acid transport
PspR84_00315	COG5487	UPF0391 membrane protein
PspR84_00325	COG2204	response regulator
PspR84_00330	COG5002	protein histidine kinase activity
PspR84_00335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PspR84_00340	COG3023	N-Acetylmuramoyl-L-alanine amidase
PspR84_00345	COG3706	GGDEF domain
PspR84_00345	COG0745	RESPONSE REGULATOR receiver
PspR84_00355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PspR84_00370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PspR84_00390	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PspR84_00395	COG0735	belongs to the Fur family
PspR84_00400	COG1121	(ABC) transporter
PspR84_00405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PspR84_00420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PspR84_00425	COG2011	ABC-type metal ion transport system permease component
PspR84_00440	COG0109	protoheme IX farnesyltransferase activity
PspR84_00455	COG3346	SURF1 family
PspR84_00470	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PspR84_00475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PspR84_00480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PspR84_00490	COG0659	secondary active sulfate transmembrane transporter activity
PspR84_00535	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PspR84_00540	COG0339	signal peptide processing
PspR84_00545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PspR84_00575	COG1764	response to oxidative stress
PspR84_00580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspR84_00605	COG0133	tryptophan synthase activity
PspR84_00610	COG0159	tryptophan synthase activity
PspR84_00650	COG0427	acetyl-CoA hydrolase
PspR84_00655	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PspR84_00660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PspR84_00665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PspR84_00670	COG0583	DNA-binding transcription factor activity
PspR84_00730	COG3712	iron ion homeostasis
PspR84_00735	COG1595	DNA-templated transcription, initiation
PspR84_00740	COG0840	transmembrane signaling receptor activity
PspR84_00765	COG1802	Transcriptional regulator
PspR84_00775	COG5001	Diguanylate cyclase
PspR84_00775	COG3300	MHYT domain
PspR84_00790	COG1538	Outer membrane efflux protein
PspR84_00800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_00805	COG2175	clavaminate synthase activity
PspR84_00810	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PspR84_00815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspR84_00845	COG0330	HflC and HflK could
PspR84_00880	COG1289	transmembrane transporter activity
PspR84_00890	COG1566	PFAM secretion protein HlyD family protein
PspR84_00905	COG5339	Protein conserved in bacteria
PspR84_00910	COG0457	Tetratricopeptide repeat
PspR84_00915	COG1649	PFAM Uncharacterised BCR, COG1649
PspR84_00915	COG0726	polysaccharide deacetylase
PspR84_00920	COG1215	transferase activity, transferring glycosyl groups
PspR84_00930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PspR84_00940	COG2304	oxidoreductase activity
PspR84_00945	COG1595	DNA-templated transcription, initiation
PspR84_00965	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_00970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PspR84_00980	COG3706	GGDEF domain
PspR84_00980	COG0745	RESPONSE REGULATOR receiver
PspR84_01000	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PspR84_01010	COG4208	sulfate ABC transporter
PspR84_01015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PspR84_01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspR84_01085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspR84_01110	COG4771	TonB-dependent receptor
PspR84_01145	COG3829	transcription factor binding
PspR84_01155	COG0765	amino acid transport
PspR84_01160	COG0765	amino acid transport
PspR84_01165	COG1126	abc transporter atp-binding protein
PspR84_01170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_01175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PspR84_01205	COG2011	ABC-type metal ion transport system permease component
PspR84_01210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PspR84_01215	COG1464	Belongs to the NlpA lipoprotein family
PspR84_01255	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PspR84_01260	COG1045	serine acetyltransferase
PspR84_01265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PspR84_01275	COG1609	Transcriptional regulator
PspR84_01290	COG0667	Aldo Keto reductase
PspR84_01295	COG2175	clavaminate synthase activity
PspR84_01300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspR84_01305	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PspR84_01310	COG4521	taurine ABC transporter
PspR84_01315	COG2918	glutathione biosynthetic process
PspR84_01325	COG2183	response to ionizing radiation
PspR84_01330	COG0745	RESPONSE REGULATOR receiver
PspR84_01340	COG0189	ligase activity
PspR84_01345	COG0189	ligase activity
PspR84_01345	COG4067	protein conserved in archaea
PspR84_01350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PspR84_01360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PspR84_01365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PspR84_01405	COG0514	ATP-dependent DNA helicase (RecQ)
PspR84_01410	COG1024	Enoyl-CoA hydratase
PspR84_01410	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspR84_01425	COG0243	molybdopterin cofactor binding
PspR84_01430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PspR84_01435	COG0583	DNA-binding transcription factor activity
PspR84_01440	COG1652	LysM domain
PspR84_01445	COG1011	Hydrolase
PspR84_01450	COG0494	nUDIX hydrolase
PspR84_01455	COG1218	3'(2'),5'-bisphosphate nucleotidase
PspR84_01480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspR84_01490	COG2957	Belongs to the agmatine deiminase family
PspR84_01540	COG5642	Protein of unknown function (DUF2384)
PspR84_01555	COG1724	mRNA binding
PspR84_01560	COG1598	PFAM Uncharacterised protein family UPF0150
PspR84_01640	COG4695	Portal protein
PspR84_01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_01845	COG4804	nuclease activity
PspR84_01885	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PspR84_01890	COG1194	a g-specific adenine glycosylase
PspR84_01910	COG0131	Imidazoleglycerol-phosphate dehydratase
PspR84_01915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PspR84_01925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PspR84_01930	COG0107	imidazoleglycerol-phosphate synthase activity
PspR84_01945	COG2861	carbohydrate metabolic process
PspR84_01950	COG0793	Belongs to the peptidase S41A family
PspR84_01955	COG4942	peptidase
PspR84_01960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PspR84_01965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PspR84_01975	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PspR84_01980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PspR84_02000	COG3852	Histidine kinase
PspR84_02025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PspR84_02025	COG0301	tRNA thio-modification
PspR84_02040	COG0058	SHG alpha-glucan phosphorylase activity
PspR84_02055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PspR84_02085	COG3040	lipid binding
PspR84_02090	COG0402	S-adenosylhomocysteine deaminase activity
PspR84_02095	COG2188	Transcriptional regulator
PspR84_02105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PspR84_02110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PspR84_02120	COG4176	ABC-type proline glycine betaine transport system permease component
PspR84_02125	COG0517	IMP dehydrogenase activity
PspR84_02125	COG4175	Glycine betaine
PspR84_02130	COG2986	histidine ammonia-lyase
PspR84_02135	COG2986	histidine ammonia-lyase
PspR84_02140	COG1228	amidohydrolase
PspR84_02150	COG0596	Alpha beta hydrolase
PspR84_02155	COG1490	D-aminoacyl-tRNA deacylase activity
PspR84_02160	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PspR84_02165	COG2943	transferase activity, transferring hexosyl groups
PspR84_02175	COG0765	amino acid transport
PspR84_02185	COG0840	transmembrane signaling receptor activity
PspR84_02200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PspR84_02205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PspR84_02210	COG0140	phosphoribosyl-ATP diphosphatase activity
PspR84_02215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PspR84_02220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PspR84_02230	COG2226	methyltransferase
PspR84_02250	COG1309	transcriptional regulator
PspR84_02275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PspR84_02280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PspR84_02290	COG0018	arginyl-trna synthetase
PspR84_02295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PspR84_02300	COG0254	rRNA binding
PspR84_02310	COG0281	malic enzyme
PspR84_02345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PspR84_02350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PspR84_02365	COG0069	glutamate synthase activity
PspR84_02365	COG0067	glutamate synthase
PspR84_02365	COG0070	glutamate synthase
PspR84_02370	COG0493	'glutamate synthase
PspR84_02375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PspR84_02380	COG2814	Major facilitator Superfamily
PspR84_02385	COG0583	DNA-binding transcription factor activity
PspR84_02400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspR84_02405	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_02415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspR84_02425	COG2226	methyltransferase
PspR84_02455	COG2986	histidine ammonia-lyase
PspR84_02470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PspR84_02480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspR84_02485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspR84_02500	COG1192	Involved in chromosome partitioning
PspR84_02505	COG3118	belongs to the thioredoxin family
PspR84_02515	COG5499	transcription regulator containing HTH domain
PspR84_02520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PspR84_02525	COG1196	nuclear chromosome segregation
PspR84_02525	COG3264	Mechanosensitive ion channel
PspR84_02530	COG3263	regulation of cellular component size
PspR84_02550	COG0840	transmembrane signaling receptor activity
PspR84_02560	COG1960	acyl-CoA dehydrogenase activity
PspR84_02570	COG0506	proline dehydrogenase activity
PspR84_02570	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PspR84_02570	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PspR84_02575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PspR84_02580	COG3501	Rhs element vgr protein
PspR84_02595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PspR84_02600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspR84_02625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PspR84_02630	COG0859	PFAM glycosyl transferase family 9
PspR84_02635	COG0859	PFAM glycosyl transferase family 9
PspR84_02640	COG0438	transferase activity, transferring glycosyl groups
PspR84_02670	COG2192	nodulation
PspR84_02675	COG1215	transferase activity, transferring glycosyl groups
PspR84_02690	COG1132	(ABC) transporter
PspR84_02705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PspR84_02705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PspR84_02730	COG0667	Aldo Keto reductase
PspR84_02750	COG1519	Transferase
PspR84_02755	COG1538	Outer membrane efflux protein
PspR84_02760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PspR84_02775	COG0494	nUDIX hydrolase
PspR84_02785	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PspR84_02790	COG3150	esterase
PspR84_02805	COG3577	Aspartyl protease
PspR84_02840	COG0688	phosphatidylethanolamine metabolic process
PspR84_02860	COG1360	Flagellar Motor Protein
PspR84_02870	COG1162	GTPase activity
PspR84_02875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PspR84_02880	COG2860	membrane
PspR84_02890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PspR84_02890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PspR84_02895	COG0802	atpase or kinase
PspR84_02900	COG0860	N-Acetylmuramoyl-L-alanine amidase
PspR84_02905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PspR84_02910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PspR84_02915	COG1923	regulation of RNA biosynthetic process
PspR84_02920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PspR84_02925	COG0330	HflC and HflK could
PspR84_02930	COG0330	HflC and HflK could
PspR84_02935	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PspR84_02940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PspR84_02950	COG1178	ABC-type Fe3 transport system permease component
PspR84_02955	COG1840	ABC-type Fe3 transport system, periplasmic component
PspR84_02970	COG0557	exoribonuclease II activity
PspR84_02975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PspR84_02980	COG0360	Binds together with S18 to 16S ribosomal RNA
PspR84_02985	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PspR84_02995	COG0359	binds to the 23S rRNA
PspR84_03000	COG0305	Participates in initiation and elongation during chromosome replication
PspR84_03035	COG1032	radical SAM domain protein
PspR84_03045	COG2308	Evidence 4 Homologs of previously reported genes of
PspR84_03045	COG2307	Protein conserved in bacteria
PspR84_03070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PspR84_03075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PspR84_03080	COG0583	DNA-binding transcription factor activity
PspR84_03085	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_03090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_03100	COG0559	Belongs to the binding-protein-dependent transport system permease family
PspR84_03115	COG0410	ABC transporter
PspR84_03120	COG4221	oxidoreductase activity
PspR84_03140	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PspR84_03145	COG0830	nickel cation binding
PspR84_03150	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PspR84_03155	COG1309	transcriptional regulator
PspR84_03165	COG2982	Protein involved in outer membrane biogenesis
PspR84_03175	COG0583	DNA-binding transcription factor activity
PspR84_03185	COG2076	Multidrug Resistance protein
PspR84_03190	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PspR84_03200	COG0697	spore germination
PspR84_03220	COG0443	Heat shock 70 kDa protein
PspR84_03230	COG0484	heat shock protein binding
PspR84_03235	COG0789	Transcriptional regulator
PspR84_03245	COG0804	urea catabolic process
PspR84_03250	COG0832	Belongs to the urease beta subunit family
PspR84_03265	COG0831	urea catabolic process
PspR84_03270	COG0829	nickel cation binding
PspR84_03275	COG0410	ABC transporter
PspR84_03280	COG0411	ABC transporter
PspR84_03290	COG0559	Belongs to the binding-protein-dependent transport system permease family
PspR84_03295	COG0683	leucine binding
PspR84_03345	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PspR84_03385	COG2095	MarC family integral membrane protein
PspR84_03395	COG0151	Belongs to the GarS family
PspR84_03400	COG0138	bifunctional purine biosynthesis protein purh
PspR84_03410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PspR84_03420	COG2264	protein methyltransferase activity
PspR84_03450	COG3706	GGDEF domain
PspR84_03450	COG0745	RESPONSE REGULATOR receiver
PspR84_03465	COG0023	Translation Initiation Factor
PspR84_03470	COG1166	arginine decarboxylase activity
PspR84_03475	COG3501	Rhs element vgr protein
PspR84_03490	COG0534	Mate efflux family protein
PspR84_03505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PspR84_03580	COG4964	Belongs to the GSP D family
PspR84_03620	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_03625	COG0183	Belongs to the thiolase family
PspR84_03645	COG2217	Heavy metal translocating P-type atpase
PspR84_03660	COG2814	Major facilitator Superfamily
PspR84_03665	COG0604	alcohol dehydrogenase
PspR84_03675	COG0583	DNA-binding transcription factor activity
PspR84_03685	COG0477	Major facilitator Superfamily
PspR84_03690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PspR84_03705	COG0387	Pfam Sodium calcium exchanger
PspR84_03745	COG1739	Uncharacterized protein family UPF0029
PspR84_03750	COG1309	transcriptional regulator
PspR84_03755	COG2233	PERMEase
PspR84_03805	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PspR84_03810	COG1074	ATP-dependent DNA helicase activity
PspR84_03815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PspR84_03825	COG2199	diguanylate cyclase activity
PspR84_03855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspR84_03860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspR84_03870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspR84_03885	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_03915	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspR84_03935	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspR84_03940	COG0583	DNA-binding transcription factor activity
PspR84_03955	COG2610	gluconate transmembrane transporter activity
PspR84_03965	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PspR84_03990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PspR84_03995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PspR84_04020	COG0840	transmembrane signaling receptor activity
PspR84_04035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PspR84_04060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PspR84_04070	COG0582	viral genome integration into host DNA
PspR84_04085	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspR84_04145	COG1484	DNA-dependent DNA replication
PspR84_04150	COG0305	Participates in initiation and elongation during chromosome replication
PspR84_04205	COG4695	Portal protein
PspR84_04380	COG0247	lactate metabolic process
PspR84_04385	COG1620	l-lactate permease
PspR84_04390	COG2186	Transcriptional regulator
PspR84_04395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PspR84_04400	COG0733	neurotransmitter:sodium symporter activity
PspR84_04410	COG2914	Belongs to the UPF0125 (RnfH) family
PspR84_04415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PspR84_04420	COG0735	belongs to the Fur family
PspR84_04425	COG0497	DNA recombination
PspR84_04430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PspR84_04435	COG0443	Heat shock 70 kDa protein
PspR84_04440	COG0484	heat shock protein binding
PspR84_04445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PspR84_04450	COG0505	Belongs to the CarA family
PspR84_04455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PspR84_04460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspR84_04475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PspR84_04480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PspR84_04485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PspR84_04490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PspR84_04495	COG0149	triose-phosphate isomerase activity
PspR84_04500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PspR84_04515	COG0779	Required for maturation of 30S ribosomal subunits
PspR84_04520	COG0195	Participates in both transcription termination and antitermination
PspR84_04525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PspR84_04530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PspR84_04535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PspR84_04540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PspR84_04545	COG1185	polyribonucleotide nucleotidyltransferase activity
PspR84_04585	COG0084	hydrolase, TatD family'
PspR84_04590	COG1609	Transcriptional regulator
PspR84_04600	COG1105	Belongs to the carbohydrate kinase PfkB family
PspR84_04605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PspR84_04605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PspR84_04605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PspR84_04615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PspR84_04620	COG4774	siderophore transport
PspR84_04625	COG3128	pkhd-type hydroxylase
PspR84_04635	COG0019	diaminopimelate decarboxylase activity
PspR84_04665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PspR84_04680	COG4608	Belongs to the ABC transporter superfamily
PspR84_04685	COG0444	Belongs to the ABC transporter superfamily
PspR84_04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PspR84_04695	COG0601	transmembrane transport
PspR84_04700	COG0747	negative chemotaxis
PspR84_04710	COG0747	negative chemotaxis
PspR84_04715	COG0747	negative chemotaxis
PspR84_04720	COG0747	negative chemotaxis
PspR84_04740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PspR84_04745	COG4178	(ABC) transporter
PspR84_04760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspR84_04770	COG2271	Major facilitator Superfamily
PspR84_04775	COG2721	sulfolactate sulfo-lyase activity
PspR84_04785	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspR84_04795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PspR84_04800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PspR84_04805	COG0154	amidase activity
PspR84_04810	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PspR84_04815	COG1077	Cell shape determining protein MreB Mrl
PspR84_04820	COG1792	Involved in formation and maintenance of cell shape
PspR84_04825	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PspR84_04830	COG0424	maF-like protein
PspR84_04835	COG1530	ribonuclease E activity
PspR84_04845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspR84_04850	COG0312	modulator of DNA gyrase
PspR84_04855	COG3028	Belongs to the UPF0307 family
PspR84_04860	COG0312	modulator of DNA gyrase
PspR84_04895	COG1660	Displays ATPase and GTPase activities
PspR84_04905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PspR84_04910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PspR84_04915	COG1137	ATPase activity
PspR84_04920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PspR84_04930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PspR84_04940	COG1127	ABC transporter
PspR84_04945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PspR84_04950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PspR84_04970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PspR84_04975	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PspR84_04980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PspR84_04985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PspR84_05000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PspR84_05010	COG0175	sulfate reduction
PspR84_05020	COG0204	Acyl-transferase
PspR84_05025	COG0857	belongs to the CobB CobQ family
PspR84_05025	COG0280	phosphate acetyltransferase
PspR84_05040	COG0386	Belongs to the glutathione peroxidase family
PspR84_05055	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PspR84_05065	COG0492	ferredoxin-NADP+ reductase activity
PspR84_05080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PspR84_05085	COG0302	gtp cyclohydrolase
PspR84_05100	COG0789	Transcriptional regulator
PspR84_05110	COG1366	Belongs to the anti-sigma-factor antagonist family
PspR84_05120	COG0583	DNA-binding transcription factor activity
PspR84_05125	COG1380	Effector of murein hydrolase LrgA
PspR84_05130	COG1346	cytolysis
PspR84_05145	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_05160	COG2909	trisaccharide binding
PspR84_05175	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PspR84_05180	COG0179	Fumarylacetoacetate (FAA) hydrolase
PspR84_05200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PspR84_05220	COG0814	amino acid
PspR84_05225	COG1760	l-serine dehydratase
PspR84_05230	COG0583	DNA-binding transcription factor activity
PspR84_05240	COG2852	Protein conserved in bacteria
PspR84_05245	COG4772	TonB-dependent receptor
PspR84_05250	COG3712	iron ion homeostasis
PspR84_05255	COG1595	DNA-templated transcription, initiation
PspR84_05285	COG4774	siderophore transport
PspR84_05305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspR84_05320	COG0583	DNA-binding transcription factor activity
PspR84_05340	COG1566	PFAM secretion protein HlyD family protein
PspR84_05345	COG0300	oxidoreductase activity
PspR84_05360	COG0662	Cupin 2, conserved barrel domain protein
PspR84_05360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PspR84_05375	COG1696	Membrane protein involved in D-alanine export
PspR84_05390	COG3420	alginic acid biosynthetic process
PspR84_05400	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PspR84_05405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_05410	COG1215	transferase activity, transferring glycosyl groups
PspR84_05420	COG3022	response to hydroperoxide
PspR84_05430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PspR84_05435	COG0315	cyclic pyranopterin monophosphate synthase activity
PspR84_05440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PspR84_05450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_05470	COG0513	Belongs to the DEAD box helicase family
PspR84_05475	COG0400	carboxylic ester hydrolase activity
PspR84_05480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_05485	COG4597	amino acid ABC transporter
PspR84_05490	COG0765	amino acid transport
PspR84_05495	COG1126	abc transporter atp-binding protein
PspR84_05510	COG2186	Transcriptional regulator
PspR84_05515	COG2807	transmembrane transport
PspR84_05525	COG2827	Endonuclease containing a URI domain
PspR84_05540	COG3081	Nucleoid-associated protein
PspR84_05550	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PspR84_05555	COG0525	valine-tRNA ligase activity
PspR84_05570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PspR84_05575	COG0795	lipopolysaccharide-transporting ATPase activity
PspR84_05580	COG0795	lipopolysaccharide-transporting ATPase activity
PspR84_05585	COG0481	GTPase activity
PspR84_05590	COG0681	Belongs to the peptidase S26 family
PspR84_05595	COG0571	ribonuclease III activity
PspR84_05600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PspR84_05605	COG1381	Involved in DNA repair and RecF pathway recombination
PspR84_05610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PspR84_05615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PspR84_05620	COG0047	phosphoribosylformylglycinamidine synthase activity
PspR84_05620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PspR84_05625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PspR84_05635	COG1263	PTS System
PspR84_05635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PspR84_05635	COG2190	(PTS) system
PspR84_05640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PspR84_05640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PspR84_05645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PspR84_05650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PspR84_05655	COG2188	Transcriptional regulator
PspR84_05670	COG0494	nUDIX hydrolase
PspR84_05690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PspR84_05695	COG0477	Major facilitator Superfamily
PspR84_05700	COG4536	flavin adenine dinucleotide binding
PspR84_05710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PspR84_05715	COG0228	four-way junction DNA binding
PspR84_05720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PspR84_05725	COG0336	Belongs to the RNA methyltransferase TrmD family
PspR84_05730	COG0335	large ribosomal subunit rRNA binding
PspR84_05735	COG1607	acyl-coa hydrolase
PspR84_05745	COG4974	Belongs to the 'phage' integrase family
PspR84_05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_05765	COG2205	protein histidine kinase activity
PspR84_05785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PspR84_05790	COG4681	YaeQ
PspR84_05800	COG1902	pentaerythritol trinitrate reductase activity
PspR84_05805	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PspR84_05830	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_05835	COG1177	transmembrane transport
PspR84_05840	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspR84_05845	COG3842	ATPase activity
PspR84_05850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PspR84_05860	COG0583	DNA-binding transcription factor activity
PspR84_05885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PspR84_05885	COG0457	Tetratricopeptide repeat
PspR84_05900	COG2201	protein-glutamate methylesterase activity
PspR84_05905	COG5001	Diguanylate cyclase
PspR84_05905	COG2203	Gaf domain
PspR84_05905	COG3706	GGDEF domain
PspR84_05905	COG4251	negative regulation of phosphorylation
PspR84_05910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PspR84_05930	COG1073	alpha beta
PspR84_05940	COG2885	chlorophyll binding
PspR84_05955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PspR84_05965	COG0563	adenylate kinase activity
PspR84_05970	COG1214	PFAM Peptidase M22, glycoprotease
PspR84_05980	COG1801	Protein of unknown function DUF72
PspR84_06000	COG0742	ribosomal rna small subunit methyltransferase
PspR84_06010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_06035	COG2937	Belongs to the GPAT DAPAT family
PspR84_06050	COG2226	methyltransferase
PspR84_06055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PspR84_06060	COG1215	transferase activity, transferring glycosyl groups
PspR84_06065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PspR84_06075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PspR84_06080	COG2171	N-acyltransferase activity
PspR84_06085	COG1393	Belongs to the ArsC family
PspR84_06090	COG0025	NhaP-type Na H and K H
PspR84_06100	COG0436	Aminotransferase
PspR84_06105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PspR84_06110	COG0024	Methionine aminopeptidase
PspR84_06115	COG0052	Belongs to the universal ribosomal protein uS2 family
PspR84_06120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PspR84_06125	COG0528	UMP kinase activity
PspR84_06130	COG0233	cytoplasmic translational termination
PspR84_06135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PspR84_06145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PspR84_06165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspR84_06170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PspR84_06175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspR84_06180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspR84_06185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PspR84_06190	COG0587	DNA-directed DNA polymerase activity
PspR84_06195	COG0825	malonyl-CoA metabolic process
PspR84_06200	COG0037	tRNA processing
PspR84_06205	COG0504	CTP synthase activity
PspR84_06210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PspR84_06215	COG0148	phosphopyruvate hydratase activity
PspR84_06225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PspR84_06235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PspR84_06240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PspR84_06245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PspR84_06250	COG0585	pseudouridine synthase activity
PspR84_06255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PspR84_06260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PspR84_06280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PspR84_06395	COG4386	tail sheath protein
PspR84_06430	COG4381	Mu-like prophage protein gp46
PspR84_06485	COG3179	chitinase
PspR84_06495	COG1546	Belongs to the CinA family
PspR84_06500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PspR84_06505	COG2137	regulation of response to DNA damage stimulus
PspR84_06540	COG0583	DNA-binding transcription factor activity
PspR84_06560	COG4807	Protein conserved in bacteria
PspR84_06575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PspR84_06580	COG3158	transport of potassium into the cell
PspR84_06630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PspR84_06640	COG0442	prolyl-tRNA aminoacylation
PspR84_06645	COG2211	Major facilitator Superfamily
PspR84_06660	COG1278	Cold shock
PspR84_06665	COG0717	Belongs to the dCTP deaminase family
PspR84_06680	COG1201	RNA secondary structure unwinding
PspR84_06685	COG4598	ABC transporter
PspR84_06695	COG4160	amino acid transport
PspR84_06700	COG4215	(ABC) transporter
PspR84_06710	COG1793	dna ligase
PspR84_06720	COG2366	antibiotic biosynthetic process
PspR84_06725	COG0625	glutathione transferase activity
PspR84_06735	COG0653	protein targeting
PspR84_06745	COG3012	SEC-C Motif Domain Protein
PspR84_06780	COG1199	ATP-dependent helicase activity
PspR84_06795	COG2885	chlorophyll binding
PspR84_06800	COG0259	pyridoxamine-phosphate oxidase activity
PspR84_06825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PspR84_06835	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PspR84_06850	COG0583	DNA-binding transcription factor activity
PspR84_06865	COG3220	belongs to the UPF0276 family
PspR84_06915	COG2084	Dehydrogenase
PspR84_06930	COG2271	Major facilitator Superfamily
PspR84_06935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PspR84_06950	COG0306	phosphate transporter
PspR84_06960	COG1414	Transcriptional regulator
PspR84_06965	COG2814	Major facilitator Superfamily
PspR84_06970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PspR84_06975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PspR84_06980	COG0183	Belongs to the thiolase family
PspR84_06985	COG3485	protocatechuate 3,4-dioxygenase
PspR84_06990	COG3485	protocatechuate 3,4-dioxygenase
PspR84_06995	COG0477	Major facilitator Superfamily
PspR84_07005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspR84_07010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspR84_07030	COG1538	Outer membrane efflux protein
PspR84_07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_07045	COG1309	transcriptional regulator
PspR84_07050	COG1902	pentaerythritol trinitrate reductase activity
PspR84_07055	COG2814	Major facilitator Superfamily
PspR84_07100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspR84_07110	COG1704	LemA family
PspR84_07115	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PspR84_07130	COG0697	spore germination
PspR84_07135	COG0693	protein deglycase activity
PspR84_07145	COG3422	double-strand break repair
PspR84_07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspR84_07155	COG0235	Class ii aldolase
PspR84_07160	COG1396	sequence-specific DNA binding
PspR84_07170	COG1454	alcohol dehydrogenase
PspR84_07180	COG2814	Major facilitator Superfamily
PspR84_07190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PspR84_07195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PspR84_07200	COG2271	Major facilitator Superfamily
PspR84_07255	COG4106	trans-aconitate 2-methyltransferase activity
PspR84_07305	COG2267	carboxylic ester hydrolase activity
PspR84_07320	COG0745	RESPONSE REGULATOR receiver
PspR84_07320	COG3706	GGDEF domain
PspR84_07330	COG0439	Biotin carboxylase
PspR84_07345	COG3842	ATPase activity
PspR84_07395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PspR84_07445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PspR84_07475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PspR84_07480	COG4783	chaperone-mediated protein folding
PspR84_07485	COG0425	Belongs to the sulfur carrier protein TusA family
PspR84_07490	COG0628	permease
PspR84_07495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PspR84_07510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspR84_07515	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PspR84_07520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PspR84_07525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PspR84_07535	COG1216	Glycosyl transferase, family 2
PspR84_07535	COG0438	transferase activity, transferring glycosyl groups
PspR84_07545	COG0463	Glycosyl transferase, family 2
PspR84_07580	COG2807	transmembrane transport
PspR84_07585	COG2194	sulfuric ester hydrolase activity
PspR84_07595	COG3100	YcgL domain-containing protein
PspR84_07610	COG2983	Belongs to the UPF0260 family
PspR84_07630	COG1403	HNH endonuclease
PspR84_07650	COG1770	oligopeptidase
PspR84_07660	COG0121	glutamine amidotransferase
PspR84_07670	COG0583	DNA-binding transcription factor activity
PspR84_07680	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PspR84_07685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PspR84_07690	COG1984	allophanate hydrolase subunit 2
PspR84_07700	COG0542	response to heat
PspR84_07715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PspR84_07740	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PspR84_07745	COG1643	Atp-dependent helicase
PspR84_07755	COG1595	DNA-templated transcription, initiation
PspR84_07765	COG2188	Transcriptional regulator
PspR84_07775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PspR84_07780	COG1132	(ABC) transporter
PspR84_07790	COG2267	carboxylic ester hydrolase activity
PspR84_07805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspR84_07815	COG0668	transmembrane transport
PspR84_07820	COG0513	Belongs to the DEAD box helicase family
PspR84_07865	COG2996	Protein conserved in bacteria
PspR84_07875	COG0697	spore germination
PspR84_07885	COG0583	DNA-binding transcription factor activity
PspR84_07895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PspR84_07900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PspR84_07930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_07935	COG2274	protein secretion by the type I secretion system
PspR84_07970	COG2832	Protein of unknown function (DUF454)
PspR84_07995	COG1752	Esterase of the alpha-beta hydrolase superfamily
PspR84_08010	COG2207	Transcriptional regulator
PspR84_08035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PspR84_08040	COG0778	Nitroreductase
PspR84_08045	COG0642	Histidine kinase
PspR84_08055	COG0745	RESPONSE REGULATOR receiver
PspR84_08065	COG2350	Protein conserved in bacteria
PspR84_08070	COG2917	probably involved in intracellular septation
PspR84_08075	COG0613	PHP domain protein
PspR84_08080	COG0009	L-threonylcarbamoyladenylate synthase
PspR84_08090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PspR84_08110	COG1113	amino acid transport
PspR84_08130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PspR84_08190	COG2154	pterin-4-alpha-carbinolamine dehydratase
PspR84_08200	COG3283	Transcriptional regulator of aromatic amino acids metabolism
PspR84_08205	COG4787	bacterial-type flagellum-dependent cell motility
PspR84_08210	COG4786	Flagellar basal body rod
PspR84_08215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PspR84_08220	COG1706	bacterial-type flagellum-dependent cell motility
PspR84_08230	COG1256	bacterial-type flagellum assembly
PspR84_08240	COG1216	Glycosyl transferase, family 2
PspR84_08240	COG0438	transferase activity, transferring glycosyl groups
PspR84_08250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PspR84_08260	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PspR84_08270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_08285	COG1216	Glycosyl transferase, family 2
PspR84_08285	COG0438	transferase activity, transferring glycosyl groups
PspR84_08290	COG1086	Polysaccharide biosynthesis protein
PspR84_08295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PspR84_08305	COG1083	cytidylyl-transferase
PspR84_08315	COG2089	acid synthase
PspR84_08360	COG2204	response regulator
PspR84_08365	COG3852	Histidine kinase
PspR84_08370	COG2204	response regulator
PspR84_08410	COG0745	RESPONSE REGULATOR receiver
PspR84_08425	COG1580	Controls the rotational direction of flagella during chemotaxis
PspR84_08450	COG1987	bacterial-type flagellum assembly
PspR84_08490	COG0455	bacterial-type flagellum organization
PspR84_08505	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PspR84_08510	COG0643	Histidine kinase
PspR84_08510	COG2198	Histidine kinase
PspR84_08515	COG2201	protein-glutamate methylesterase activity
PspR84_08520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PspR84_08530	COG1192	Involved in chromosome partitioning
PspR84_08540	COG0835	chemotaxis
PspR84_08560	COG4133	protoheme IX ABC transporter activity
PspR84_08580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PspR84_08585	COG1138	Cytochrome C-type biogenesis protein
PspR84_08595	COG3088	subunit of a heme lyase
PspR84_08615	COG1598	PFAM Uncharacterised protein family UPF0150
PspR84_08620	COG2814	Major facilitator Superfamily
PspR84_08635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PspR84_08645	COG0469	pyruvate kinase activity
PspR84_08655	COG2084	Dehydrogenase
PspR84_08660	COG3622	Belongs to the hyi family
PspR84_08665	COG3960	tartronate-semialdehyde synthase activity
PspR84_08680	COG1309	transcriptional regulator
PspR84_08685	COG2354	Protein conserved in bacteria
PspR84_08690	COG2853	Lipoprotein
PspR84_08715	COG2113	Glycine betaine
PspR84_08720	COG3162	membrane
PspR84_08725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PspR84_08740	COG2009	succinate dehydrogenase
PspR84_08745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PspR84_08750	COG1053	succinate dehydrogenase
PspR84_08755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PspR84_08770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspR84_08775	COG0045	succinate-CoA ligase (ADP-forming) activity
PspR84_08815	COG0326	Molecular chaperone. Has ATPase activity
PspR84_08825	COG1741	Belongs to the pirin family
PspR84_08850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PspR84_08855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PspR84_08865	COG0628	permease
PspR84_08870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PspR84_08875	COG0791	NLP P60 protein
PspR84_08880	COG0791	NLP P60 protein
PspR84_08900	COG1797	cobyrinic acid a,c-diamide synthase activity
PspR84_08905	COG0778	Nitroreductase
PspR84_08920	COG1492	cobalamin metabolic process
PspR84_08930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PspR84_08940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PspR84_09020	COG2076	Multidrug Resistance protein
PspR84_09025	COG0385	Bile acid
PspR84_09030	COG2974	May be involved in recombination
PspR84_09060	COG0753	catalase activity
PspR84_09065	COG2010	Cytochrome c
PspR84_09070	COG0545	Peptidyl-prolyl cis-trans isomerase
PspR84_09095	COG3209	COG3209 Rhs family protein
PspR84_09105	COG2200	EAL domain
PspR84_09135	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspR84_09155	COG1473	amidohydrolase
PspR84_09160	COG0668	transmembrane transport
PspR84_09165	COG1362	aminopeptidase activity
PspR84_09170	COG0564	pseudouridine synthase activity
PspR84_09175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PspR84_09180	COG2894	cell division
PspR84_09185	COG0850	regulation of cytokinetic process
PspR84_09190	COG1560	Kdo2-lipid A biosynthetic process
PspR84_09210	COG2233	PERMEase
PspR84_09220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PspR84_09225	COG4266	Belongs to the allantoicase family
PspR84_09275	COG2252	PERMEase
PspR84_09285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_09295	COG0302	gtp cyclohydrolase
PspR84_09310	COG2840	Smr protein MutS2
PspR84_09335	COG1073	alpha beta
PspR84_09340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PspR84_09350	COG0235	Class ii aldolase
PspR84_09355	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PspR84_09360	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PspR84_09375	COG0318	PFAM AMP-dependent synthetase and ligase
PspR84_09395	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PspR84_09410	COG2308	Evidence 4 Homologs of previously reported genes of
PspR84_09420	COG1305	Transglutaminase-like
PspR84_09430	COG0183	Belongs to the thiolase family
PspR84_09435	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspR84_09435	COG1024	Enoyl-CoA hydratase
PspR84_09440	COG0519	Catalyzes the synthesis of GMP from XMP
PspR84_09440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PspR84_09445	COG0598	Magnesium transport protein CorA
PspR84_09450	COG0204	Acyl-transferase
PspR84_09465	COG0393	Putative heavy-metal-binding
PspR84_09510	COG3209	COG3209 Rhs family protein
PspR84_09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PspR84_09520	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_09525	COG0583	DNA-binding transcription factor activity
PspR84_09535	COG1953	Uracil, thiamine, allantoin
PspR84_09545	COG0560	Phosphoserine phosphatase
PspR84_09560	COG0189	ligase activity
PspR84_09570	COG0189	ligase activity
PspR84_09570	COG4067	protein conserved in archaea
PspR84_09575	COG1802	Transcriptional regulator
PspR84_09585	COG0372	Belongs to the citrate synthase family
PspR84_09600	COG2079	MmgE PrpD family protein
PspR84_09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_09615	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PspR84_09630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PspR84_09645	COG0668	transmembrane transport
PspR84_09660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PspR84_09665	COG0243	molybdopterin cofactor binding
PspR84_09670	COG2146	nitrite reductase [NAD(P)H] activity
PspR84_09675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PspR84_09680	COG0515	serine threonine protein kinase
PspR84_09680	COG2815	serine threonine protein kinase
PspR84_09685	COG2223	nitrite transmembrane transporter activity
PspR84_09695	COG3707	response regulator
PspR84_09700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspR84_09700	COG1116	anion transmembrane transporter activity
PspR84_09705	COG0167	dihydroorotate dehydrogenase activity
PspR84_09710	COG3130	regulation of translation
PspR84_09715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspR84_09715	COG0116	Belongs to the methyltransferase superfamily
PspR84_09720	COG3706	GGDEF domain
PspR84_09720	COG0745	RESPONSE REGULATOR receiver
PspR84_09725	COG2027	D-alanyl-D-alanine carboxypeptidase
PspR84_09730	COG3171	Protein conserved in bacteria
PspR84_09735	COG3135	benzoate transporter
PspR84_09740	COG1802	Transcriptional regulator
PspR84_09745	COG0402	S-adenosylhomocysteine deaminase activity
PspR84_09775	COG3115	cell septum assembly
PspR84_09780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PspR84_09800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PspR84_09805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PspR84_09810	COG2130	NADP-dependent
PspR84_09815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PspR84_09820	COG1960	acyl-CoA dehydrogenase activity
PspR84_09825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PspR84_09830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PspR84_09865	COG0348	domain, Protein
PspR84_09885	COG2010	Cytochrome c
PspR84_09900	COG3278	Belongs to the heme-copper respiratory oxidase family
PspR84_09905	COG2010	Cytochrome c
PspR84_09920	COG3278	Belongs to the heme-copper respiratory oxidase family
PspR84_09950	COG0840	transmembrane signaling receptor activity
PspR84_09965	COG4977	sequence-specific DNA binding
PspR84_09980	COG3387	PFAM Glycoside hydrolase 15-related
PspR84_09985	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_10005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PspR84_10025	COG4774	siderophore transport
PspR84_10060	COG1136	(ABC) transporter
PspR84_10060	COG0577	efflux transmembrane transporter activity
PspR84_10065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_10080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PspR84_10095	COG2197	response regulator
PspR84_10100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_10100	COG2198	Histidine kinase
PspR84_10100	COG2205	protein histidine kinase activity
PspR84_10100	COG0784	Response regulator, receiver
PspR84_10105	COG0656	L-ascorbic acid biosynthetic process
PspR84_10135	COG0708	Exodeoxyribonuclease III
PspR84_10160	COG2233	PERMEase
PspR84_10185	COG0556	nucleotide-excision repair
PspR84_10200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PspR84_10230	COG0596	Alpha beta hydrolase
PspR84_10240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PspR84_10255	COG2214	Heat shock protein DnaJ domain protein
PspR84_10260	COG0443	Heat shock 70 kDa protein
PspR84_10275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PspR84_10280	COG0066	3-isopropylmalate dehydratase activity
PspR84_10285	COG2226	methyltransferase
PspR84_10290	COG0473	3-isopropylmalate dehydrogenase activity
PspR84_10315	COG0135	phosphoribosylanthranilate isomerase activity
PspR84_10320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PspR84_10325	COG0285	dihydrofolate synthase activity
PspR84_10335	COG1286	toxin biosynthetic process
PspR84_10380	COG2010	Cytochrome c
PspR84_10385	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PspR84_10385	COG3608	succinylglutamate desuccinylase aspartoacylase
PspR84_10390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_10405	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspR84_10440	COG1879	ABC-type sugar transport system periplasmic component
PspR84_10445	COG1129	ABC transporter
PspR84_10450	COG1172	Belongs to the binding-protein-dependent transport system permease family
PspR84_10455	COG1609	Transcriptional regulator
PspR84_10460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PspR84_10465	COG1869	D-ribose catabolic process
PspR84_10490	COG1278	Cold shock
PspR84_10500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PspR84_10505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PspR84_10510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PspR84_10515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PspR84_10520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PspR84_10525	COG0072	phenylalanine-tRNA ligase activity
PspR84_10530	COG0776	regulation of translation
PspR84_10625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_10630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PspR84_10635	COG4948	Mandelate Racemase Muconate Lactonizing
PspR84_10645	COG0601	transmembrane transport
PspR84_10650	COG0747	negative chemotaxis
PspR84_10660	COG0444	Belongs to the ABC transporter superfamily
PspR84_10665	COG4608	Belongs to the ABC transporter superfamily
PspR84_10705	COG0604	alcohol dehydrogenase
PspR84_10705	COG3321	synthase
PspR84_10705	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_10715	COG0583	DNA-binding transcription factor activity
PspR84_10725	COG1741	Belongs to the pirin family
PspR84_10770	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PspR84_10775	COG1335	isochorismatase
PspR84_10790	COG0583	DNA-binding transcription factor activity
PspR84_10810	COG0741	lytic transglycosylase activity
PspR84_10810	COG1196	nuclear chromosome segregation
PspR84_10810	COG0739	heme binding
PspR84_10875	COG4796	Type ii and iii secretion system protein
PspR84_10905	COG1462	curli production assembly transport component CsgG
PspR84_10945	COG4191	Histidine kinase
PspR84_10960	COG4191	Histidine kinase
PspR84_10965	COG2204	response regulator
PspR84_10975	COG0500	methyltransferase
PspR84_11005	COG0726	polysaccharide deacetylase
PspR84_11025	COG0438	transferase activity, transferring glycosyl groups
PspR84_11065	COG1136	(ABC) transporter
PspR84_11100	COG2720	vancomycin resistance protein
PspR84_11150	COG3501	Rhs element vgr protein
PspR84_11160	COG5383	Protein conserved in bacteria
PspR84_11165	COG0247	lactate metabolic process
PspR84_11170	COG0277	FAD linked oxidase domain protein
PspR84_11175	COG0277	FAD linked oxidase domain protein
PspR84_11180	COG2267	carboxylic ester hydrolase activity
PspR84_11185	COG2072	flavoprotein involved in K transport
PspR84_11190	COG3706	GGDEF domain
PspR84_11200	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PspR84_11215	COG0531	amino acid
PspR84_11260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PspR84_11265	COG0583	DNA-binding transcription factor activity
PspR84_11270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PspR84_11275	COG4106	trans-aconitate 2-methyltransferase activity
PspR84_11280	COG3220	belongs to the UPF0276 family
PspR84_11290	COG2205	protein histidine kinase activity
PspR84_11295	COG0745	RESPONSE REGULATOR receiver
PspR84_11385	COG0579	oxidoreductase
PspR84_11430	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_11440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspR84_11475	COG0814	amino acid
PspR84_11495	COG0589	response to stress
PspR84_11505	COG0745	RESPONSE REGULATOR receiver
PspR84_11510	COG2205	protein histidine kinase activity
PspR84_11515	COG3791	Glutathione-dependent formaldehyde-activating
PspR84_11520	COG2066	Belongs to the glutaminase family
PspR84_11525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PspR84_11530	COG0288	reversible hydration of carbon dioxide
PspR84_11540	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PspR84_11545	COG0583	DNA-binding transcription factor activity
PspR84_11560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PspR84_11565	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PspR84_11590	COG0640	Transcriptional regulator
PspR84_11595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PspR84_11600	COG0431	NADPH-dependent FMN reductase
PspR84_11660	COG4335	DNA alkylation repair
PspR84_11675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PspR84_11680	COG0840	transmembrane signaling receptor activity
PspR84_11715	COG4774	siderophore transport
PspR84_11730	COG1320	monovalent cation:proton antiporter activity
PspR84_11735	COG2212	antiporter activity
PspR84_11745	COG0651	ATP synthesis coupled electron transport
PspR84_11750	COG1006	Multisubunit Na H antiporter MnhC subunit
PspR84_11755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PspR84_11755	COG2111	Na H antiporter
PspR84_11780	COG1611	Belongs to the LOG family
PspR84_11810	COG2135	peptidase activity
PspR84_11815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspR84_11825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspR84_11840	COG0494	nUDIX hydrolase
PspR84_11865	COG0583	DNA-binding transcription factor activity
PspR84_11875	COG4948	Mandelate Racemase Muconate Lactonizing
PspR84_11880	COG0583	DNA-binding transcription factor activity
PspR84_11885	COG0247	lactate metabolic process
PspR84_11885	COG0277	FAD linked oxidase domain protein
PspR84_11890	COG2995	paraquat-inducible protein a
PspR84_11905	COG0583	DNA-binding transcription factor activity
PspR84_11910	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_11915	COG0477	Major facilitator Superfamily
PspR84_11920	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_11925	COG0583	DNA-binding transcription factor activity
PspR84_11940	COG1733	regulation of RNA biosynthetic process
PspR84_11950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PspR84_11955	COG0583	DNA-binding transcription factor activity
PspR84_11975	COG2072	flavoprotein involved in K transport
PspR84_11995	COG2831	hemolysin activation secretion protein
PspR84_12000	COG3210	domain, Protein
PspR84_12010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspR84_12020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PspR84_12030	COG0861	Integral membrane protein TerC family
PspR84_12040	COG2207	Transcriptional regulator
PspR84_12050	COG1120	ATPase activity
PspR84_12055	COG4139	cobalamin transport
PspR84_12070	COG3712	iron ion homeostasis
PspR84_12075	COG1595	DNA-templated transcription, initiation
PspR84_12085	COG2814	Major facilitator Superfamily
PspR84_12090	COG4264	IucA IucC family
PspR84_12095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PspR84_12100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PspR84_12105	COG0019	diaminopimelate decarboxylase activity
PspR84_12120	COG4774	siderophore transport
PspR84_12150	COG0626	cystathionine gamma-synthase activity
PspR84_12160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PspR84_12170	COG1120	ATPase activity
PspR84_12175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PspR84_12180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PspR84_12195	COG0024	Methionine aminopeptidase
PspR84_12200	COG3842	ATPase activity
PspR84_12210	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspR84_12220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PspR84_12235	COG2186	Transcriptional regulator
PspR84_12240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspR84_12250	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_12255	COG2267	carboxylic ester hydrolase activity
PspR84_12280	COG1609	Transcriptional regulator
PspR84_12300	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_12340	COG0420	3'-5' exonuclease activity
PspR84_12430	COG0714	Associated with various cellular activities
PspR84_12470	COG4172	Belongs to the ABC transporter superfamily
PspR84_12475	COG4239	(ABC) transporter, permease
PspR84_12480	COG4174	ABC transporter (Permease)
PspR84_12485	COG4166	transmembrane transport
PspR84_12490	COG4166	transmembrane transport
PspR84_12495	COG0741	lytic transglycosylase activity
PspR84_12495	COG1388	LysM domain
PspR84_12500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PspR84_12510	COG0328	RNA-DNA hybrid ribonuclease activity
PspR84_12515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspR84_12520	COG1982	Orn Lys Arg decarboxylase major
PspR84_12540	COG0431	NADPH-dependent FMN reductase
PspR84_12545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PspR84_12555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PspR84_12560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PspR84_12565	COG0705	Rhomboid family
PspR84_12570	COG3139	Protein of unknown function (DUF1315)
PspR84_12580	COG0308	aminopeptidase N
PspR84_12585	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PspR84_12620	COG1999	signal sequence binding
PspR84_12625	COG1538	Outer membrane efflux protein
PspR84_12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_12655	COG1136	(ABC) transporter
PspR84_12655	COG0577	efflux transmembrane transporter activity
PspR84_12670	COG0745	RESPONSE REGULATOR receiver
PspR84_12670	COG3706	GGDEF domain
PspR84_12675	COG1335	isochorismatase
PspR84_12690	COG2203	Gaf domain
PspR84_12690	COG3706	GGDEF domain
PspR84_12690	COG4251	negative regulation of phosphorylation
PspR84_12690	COG5001	Diguanylate cyclase
PspR84_12700	COG3046	protein related to deoxyribodipyrimidine photolyase
PspR84_12705	COG1902	pentaerythritol trinitrate reductase activity
PspR84_12715	COG1309	transcriptional regulator
PspR84_12735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PspR84_12745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspR84_12750	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_12760	COG2271	Major facilitator Superfamily
PspR84_12765	COG2169	Transcriptional regulator
PspR84_12785	COG1902	pentaerythritol trinitrate reductase activity
PspR84_12790	COG1309	transcriptional regulator
PspR84_12795	COG1335	isochorismatase
PspR84_12800	COG2211	Major facilitator Superfamily
PspR84_12810	COG0673	inositol 2-dehydrogenase activity
PspR84_12830	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_12840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_12845	COG0747	negative chemotaxis
PspR84_12850	COG0601	transmembrane transport
PspR84_12855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PspR84_12885	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_12890	COG0473	3-isopropylmalate dehydrogenase activity
PspR84_12910	COG1522	sequence-specific DNA binding
PspR84_12920	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_12930	COG1942	4-Oxalocrotonate Tautomerase
PspR84_12940	COG3501	Rhs element vgr protein
PspR84_12965	COG2384	SAM-dependent methyltransferase
PspR84_12970	COG1064	alcohol dehydrogenase
PspR84_12985	COG0583	DNA-binding transcription factor activity
PspR84_13005	COG3938	Belongs to the proline racemase family
PspR84_13010	COG0531	amino acid
PspR84_13035	COG0456	acetyltransferase
PspR84_13035	COG1846	Transcriptional regulator
PspR84_13065	COG4948	Mandelate Racemase Muconate Lactonizing
PspR84_13070	COG4829	muconolactone delta-isomerase
PspR84_13075	COG3485	protocatechuate 3,4-dioxygenase
PspR84_13090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PspR84_13095	COG2011	ABC-type metal ion transport system permease component
PspR84_13100	COG1129	ABC transporter
PspR84_13105	COG1172	Belongs to the binding-protein-dependent transport system permease family
PspR84_13115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PspR84_13125	COG0531	amino acid
PspR84_13135	COG1511	domain protein
PspR84_13135	COG3264	Mechanosensitive ion channel
PspR84_13145	COG0583	DNA-binding transcription factor activity
PspR84_13155	COG1301	dicarboxylic acid transport
PspR84_13160	COG1902	pentaerythritol trinitrate reductase activity
PspR84_13165	COG0300	oxidoreductase activity
PspR84_13220	COG0500	methyltransferase
PspR84_13235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PspR84_13240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_13245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PspR84_13255	COG1063	alcohol dehydrogenase
PspR84_13290	COG3011	Protein conserved in bacteria
PspR84_13340	COG1234	tRNA 3'-trailer cleavage
PspR84_13355	COG4977	sequence-specific DNA binding
PspR84_13360	COG4566	intracellular signal transduction
PspR84_13385	COG1595	DNA-templated transcription, initiation
PspR84_13390	COG3712	iron ion homeostasis
PspR84_13395	COG4774	siderophore transport
PspR84_13400	COG1132	(ABC) transporter
PspR84_13415	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PspR84_13425	COG0456	acetyltransferase
PspR84_13430	COG2365	Tyrosine phosphatase family
PspR84_13475	COG1309	transcriptional regulator
PspR84_13490	COG3501	Rhs element vgr protein
PspR84_13545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspR84_13575	COG5001	Diguanylate cyclase
PspR84_13575	COG3300	MHYT domain
PspR84_13580	COG1944	ATP diphosphatase activity
PspR84_13615	COG5002	protein histidine kinase activity
PspR84_13625	COG0625	glutathione transferase activity
PspR84_13640	COG0583	DNA-binding transcription factor activity
PspR84_13655	COG0028	Belongs to the TPP enzyme family
PspR84_13670	COG0477	Major facilitator Superfamily
PspR84_13675	COG3639	organic phosphonate transmembrane transporter activity
PspR84_13680	COG3639	organic phosphonate transmembrane transporter activity
PspR84_13685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PspR84_13690	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PspR84_13695	COG0251	oxidation-reduction process
PspR84_13735	COG0826	peptidase U32
PspR84_13750	COG0583	DNA-binding transcription factor activity
PspR84_13770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PspR84_13770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PspR84_13790	COG2207	Transcriptional regulator
PspR84_13820	COG3850	Histidine kinase
PspR84_13820	COG3437	response regulator, receiver
PspR84_13820	COG2205	protein histidine kinase activity
PspR84_13820	COG4999	Histidine kinase
PspR84_13825	COG3437	response regulator, receiver
PspR84_13850	COG1522	sequence-specific DNA binding
PspR84_13855	COG0697	spore germination
PspR84_13865	COG1566	PFAM secretion protein HlyD family protein
PspR84_13905	COG0811	peptide transport
PspR84_13935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspR84_13945	COG0456	acetyltransferase
PspR84_13950	COG1794	racemase activity, acting on amino acids and derivatives
PspR84_13965	COG3278	Belongs to the heme-copper respiratory oxidase family
PspR84_13975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PspR84_14040	COG1538	Outer membrane efflux protein
PspR84_14050	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_14055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_14060	COG0348	domain, Protein
PspR84_14070	COG1285	pathogenesis
PspR84_14085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PspR84_14095	COG3568	Endonuclease Exonuclease Phosphatase
PspR84_14140	COG1640	4-alpha-glucanotransferase
PspR84_14145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PspR84_14150	COG0297	glycogen (starch) synthase activity
PspR84_14155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspR84_14160	COG0596	Alpha beta hydrolase
PspR84_14165	COG1238	metal cluster binding
PspR84_14220	COG2366	antibiotic biosynthetic process
PspR84_14260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspR84_14275	COG2233	PERMEase
PspR84_14290	COG0010	Belongs to the arginase family
PspR84_14295	COG0667	Aldo Keto reductase
PspR84_14300	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PspR84_14330	COG0154	amidase activity
PspR84_14345	COG0628	permease
PspR84_14365	COG0583	DNA-binding transcription factor activity
PspR84_14385	COG0745	RESPONSE REGULATOR receiver
PspR84_14390	COG2205	protein histidine kinase activity
PspR84_14420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_14430	COG0174	glutamine synthetase
PspR84_14435	COG0667	Aldo Keto reductase
PspR84_14470	COG1131	(ABC) transporter
PspR84_14510	COG0583	DNA-binding transcription factor activity
PspR84_14515	COG1335	isochorismatase
PspR84_14545	COG3781	membrane
PspR84_14555	COG2273	Hydrolase Family 16
PspR84_14560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PspR84_14580	COG0438	transferase activity, transferring glycosyl groups
PspR84_14585	COG0438	transferase activity, transferring glycosyl groups
PspR84_14605	COG0489	protein tyrosine kinase activity
PspR84_14630	COG0583	DNA-binding transcription factor activity
PspR84_14635	COG0604	alcohol dehydrogenase
PspR84_14645	COG1902	pentaerythritol trinitrate reductase activity
PspR84_14650	COG1733	regulation of RNA biosynthetic process
PspR84_14660	COG0583	DNA-binding transcription factor activity
PspR84_14665	COG2814	Major facilitator Superfamily
PspR84_14675	COG0583	DNA-binding transcription factor activity
PspR84_14685	COG0477	Major facilitator Superfamily
PspR84_14715	COG0583	DNA-binding transcription factor activity
PspR84_14720	COG2233	PERMEase
PspR84_14735	COG3188	usher protein
PspR84_14750	COG2200	EAL domain
PspR84_14750	COG2199	diguanylate cyclase activity
PspR84_14750	COG2203	Gaf domain
PspR84_14760	COG2205	protein histidine kinase activity
PspR84_14760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_14790	COG0745	RESPONSE REGULATOR receiver
PspR84_14795	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PspR84_14820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PspR84_14850	COG2223	nitrite transmembrane transporter activity
PspR84_14855	COG4638	Rieske (2fe-2S)
PspR84_14865	COG0583	DNA-binding transcription factor activity
PspR84_14870	COG4175	Glycine betaine
PspR84_14875	COG4176	ABC-type proline glycine betaine transport system permease component
PspR84_14880	COG2113	Glycine betaine
PspR84_14895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspR84_14900	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_14920	COG1902	pentaerythritol trinitrate reductase activity
PspR84_14925	COG2010	Cytochrome c
PspR84_14925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PspR84_14930	COG2080	2 iron, 2 sulfur cluster binding
PspR84_14935	COG2010	Cytochrome c
PspR84_14935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PspR84_14940	COG2814	Major facilitator Superfamily
PspR84_14945	COG0583	DNA-binding transcription factor activity
PspR84_14950	COG4214	carbohydrate transport
PspR84_14955	COG1129	ABC transporter
PspR84_14960	COG4213	ABC transporter substrate-binding protein
PspR84_14965	COG2115	Belongs to the xylose isomerase family
PspR84_14970	COG1609	Transcriptional regulator
PspR84_14970	COG2207	Transcriptional regulator
PspR84_14985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspR84_14995	COG1846	Transcriptional regulator
PspR84_15000	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PspR84_15015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PspR84_15020	COG1301	dicarboxylic acid transport
PspR84_15025	COG4948	Mandelate Racemase Muconate Lactonizing
PspR84_15030	COG0583	DNA-binding transcription factor activity
PspR84_15130	COG1074	ATP-dependent DNA helicase activity
PspR84_15170	COG4993	Dehydrogenase
PspR84_15175	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_15190	COG0583	DNA-binding transcription factor activity
PspR84_15210	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_15215	COG0596	Alpha beta hydrolase
PspR84_15220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_15240	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PspR84_15245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_15285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PspR84_15310	COG1228	amidohydrolase
PspR84_15365	COG3622	Belongs to the hyi family
PspR84_15375	COG1653	transport
PspR84_15390	COG3842	ATPase activity
PspR84_15405	COG4774	siderophore transport
PspR84_15410	COG3712	iron ion homeostasis
PspR84_15415	COG1595	DNA-templated transcription, initiation
PspR84_15430	COG0174	glutamine synthetase
PspR84_15440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_15445	COG3008	intermembrane lipid transfer
PspR84_15455	COG4974	Belongs to the 'phage' integrase family
PspR84_15460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PspR84_15465	COG0463	Glycosyl transferase, family 2
PspR84_15470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_15470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PspR84_15475	COG0726	polysaccharide deacetylase
PspR84_15480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PspR84_15485	COG2076	Multidrug Resistance protein
PspR84_15490	COG2076	Multidrug Resistance protein
PspR84_15510	COG2814	Major facilitator Superfamily
PspR84_15520	COG1024	Enoyl-CoA hydratase
PspR84_15525	COG1960	acyl-CoA dehydrogenase activity
PspR84_15530	COG1024	Enoyl-CoA hydratase
PspR84_15535	COG1960	acyl-CoA dehydrogenase activity
PspR84_15540	COG0183	Belongs to the thiolase family
PspR84_15550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspR84_15560	COG2207	Transcriptional regulator
PspR84_15570	COG2822	iron ion transport
PspR84_15585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspR84_15605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspR84_15615	COG2816	NAD+ diphosphatase activity
PspR84_15620	COG1024	Enoyl-CoA hydratase
PspR84_15625	COG0598	Magnesium transport protein CorA
PspR84_15640	COG2133	pyrroloquinoline quinone binding
PspR84_15650	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PspR84_15660	COG0488	(ABC) transporter
PspR84_15675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspR84_15680	COG0583	DNA-binding transcription factor activity
PspR84_15695	COG1968	undecaprenyl-diphosphatase activity
PspR84_15700	COG0840	transmembrane signaling receptor activity
PspR84_15745	COG2204	response regulator
PspR84_15760	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PspR84_15765	COG0561	phosphatase activity
PspR84_15770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PspR84_15775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PspR84_15785	COG2194	sulfuric ester hydrolase activity
PspR84_15800	COG3276	selenocysteine insertion sequence binding
PspR84_15805	COG1921	L-seryl-tRNASec selenium transferase activity
PspR84_15810	COG3058	Necessary for formate dehydrogenase activity
PspR84_15815	COG2864	formate dehydrogenase
PspR84_15820	COG0437	4 iron, 4 sulfur cluster binding
PspR84_15825	COG3383	formate dehydrogenase (NAD+) activity
PspR84_15825	COG0243	molybdopterin cofactor binding
PspR84_15830	COG3383	formate dehydrogenase (NAD+) activity
PspR84_15830	COG0243	molybdopterin cofactor binding
PspR84_15835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PspR84_15840	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_15870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspR84_15870	COG1199	ATP-dependent helicase activity
PspR84_15890	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PspR84_15895	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PspR84_15945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_15960	COG0210	DNA helicase
PspR84_15975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_15995	COG0300	oxidoreductase activity
PspR84_16000	COG2207	Transcriptional regulator
PspR84_16010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PspR84_16015	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
PspR84_16040	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_16045	COG0477	Major facilitator Superfamily
PspR84_16065	COG1605	Chorismate mutase
PspR84_16065	COG0287	Prephenate dehydrogenase
PspR84_16085	COG2207	Transcriptional regulator
PspR84_16090	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_16100	COG0583	DNA-binding transcription factor activity
PspR84_16135	COG1566	PFAM secretion protein HlyD family protein
PspR84_16155	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PspR84_16170	COG2198	Histidine kinase
PspR84_16170	COG0784	Response regulator, receiver
PspR84_16170	COG2205	protein histidine kinase activity
PspR84_16180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PspR84_16185	COG3850	Histidine kinase
PspR84_16185	COG4999	Histidine kinase
PspR84_16185	COG3437	response regulator, receiver
PspR84_16185	COG2205	protein histidine kinase activity
PspR84_16200	COG0438	transferase activity, transferring glycosyl groups
PspR84_16220	COG1175	transmembrane transport
PspR84_16235	COG0246	Mannitol dehydrogenase
PspR84_16240	COG1070	Carbohydrate kinase
PspR84_16245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PspR84_16260	COG3501	Rhs element vgr protein
PspR84_16305	COG4574	serine-type endopeptidase inhibitor activity
PspR84_16315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PspR84_16335	COG1595	DNA-templated transcription, initiation
PspR84_16345	COG2205	protein histidine kinase activity
PspR84_16350	COG0745	RESPONSE REGULATOR receiver
PspR84_16355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_16360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PspR84_16380	COG1609	Transcriptional regulator
PspR84_16390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PspR84_16415	COG1929	Belongs to the glycerate kinase type-1 family
PspR84_16420	COG3835	regulator
PspR84_16425	COG2271	Major facilitator Superfamily
PspR84_16430	COG0667	Aldo Keto reductase
PspR84_16435	COG2755	lipolytic protein G-D-S-L family
PspR84_16435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PspR84_16440	COG2962	Rard protein
PspR84_16455	COG0583	DNA-binding transcription factor activity
PspR84_16460	COG2200	EAL domain
PspR84_16480	COG3634	alkyl hydroperoxide reductase activity
PspR84_16485	COG0450	alkyl hydroperoxide reductase
PspR84_16545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PspR84_16545	COG2169	Transcriptional regulator
PspR84_16550	COG0604	alcohol dehydrogenase
PspR84_16575	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PspR84_16585	COG0488	(ABC) transporter
PspR84_16625	COG0322	excinuclease ABC activity
PspR84_16630	COG2197	response regulator
PspR84_16635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PspR84_16635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PspR84_16640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspR84_16640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PspR84_16645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PspR84_16655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PspR84_16660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspR84_16665	COG4166	transmembrane transport
PspR84_16670	COG4174	ABC transporter (Permease)
PspR84_16675	COG4239	(ABC) transporter, permease
PspR84_16680	COG4172	Belongs to the ABC transporter superfamily
PspR84_16690	COG2610	gluconate transmembrane transporter activity
PspR84_16695	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_16700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspR84_16720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspR84_16725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PspR84_16745	COG1126	abc transporter atp-binding protein
PspR84_16750	COG0765	amino acid transport
PspR84_16755	COG0765	amino acid transport
PspR84_16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_16770	COG1253	flavin adenine dinucleotide binding
PspR84_16820	COG0316	Belongs to the HesB IscA family
PspR84_16820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PspR84_16825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PspR84_16870	COG0616	signal peptide processing
PspR84_16885	COG4172	Belongs to the ABC transporter superfamily
PspR84_16890	COG4239	(ABC) transporter, permease
PspR84_16895	COG4174	ABC transporter (Permease)
PspR84_16900	COG4166	transmembrane transport
PspR84_16920	COG4206	TonB-dependent receptor
PspR84_16925	COG3712	iron ion homeostasis
PspR84_16930	COG1595	DNA-templated transcription, initiation
PspR84_16935	COG1024	Enoyl-CoA hydratase
PspR84_16935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PspR84_16975	COG1366	Belongs to the anti-sigma-factor antagonist family
PspR84_16980	COG1366	Belongs to the anti-sigma-factor antagonist family
PspR84_16985	COG2172	sigma factor antagonist activity
PspR84_17000	COG0784	Response regulator, receiver
PspR84_17000	COG4191	Histidine kinase
PspR84_17010	COG0784	Response regulator, receiver
PspR84_17010	COG4191	Histidine kinase
PspR84_17040	COG0587	DNA-directed DNA polymerase activity
PspR84_17055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PspR84_17095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspR84_17100	COG4521	taurine ABC transporter
PspR84_17110	COG2081	HI0933 family
PspR84_17120	COG0673	inositol 2-dehydrogenase activity
PspR84_17215	COG1733	regulation of RNA biosynthetic process
PspR84_17335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspR84_17350	COG2203	Gaf domain
PspR84_17350	COG2199	diguanylate cyclase activity
PspR84_17410	COG0640	Transcriptional regulator
PspR84_17430	COG4251	negative regulation of phosphorylation
PspR84_17445	COG2514	catechol 2,3-dioxygenase activity
PspR84_17450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PspR84_17450	COG2169	Transcriptional regulator
PspR84_17465	COG2259	Doxx family
PspR84_17520	COG1294	oxidase, subunit
PspR84_17525	COG1271	oxidase subunit
PspR84_17535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PspR84_17540	COG3781	membrane
PspR84_17550	COG0521	Mo-molybdopterin cofactor biosynthetic process
PspR84_17555	COG0583	DNA-binding transcription factor activity
PspR84_17560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PspR84_17570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PspR84_17585	COG0174	glutamine synthetase
PspR84_17590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_17610	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspR84_17620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PspR84_17655	COG1396	sequence-specific DNA binding
PspR84_17655	COG1917	Cupin 2, conserved barrel domain protein
PspR84_17665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_17670	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_17675	COG0174	glutamine synthetase
PspR84_17680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PspR84_17685	COG3842	ATPase activity
PspR84_17690	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspR84_17695	COG1177	transmembrane transport
PspR84_17705	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PspR84_17715	COG5507	3-demethylubiquinone-9 3-methyltransferase
PspR84_17735	COG1620	l-lactate permease
PspR84_17740	COG2080	2 iron, 2 sulfur cluster binding
PspR84_17745	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PspR84_17750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PspR84_17770	COG1073	alpha beta
PspR84_17785	COG1953	Uracil, thiamine, allantoin
PspR84_17795	COG0493	'glutamate synthase
PspR84_17805	COG1309	transcriptional regulator
PspR84_17815	COG1276	copper resistance
PspR84_17835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_17860	COG0730	response to heat
PspR84_17870	COG0640	Transcriptional regulator
PspR84_17885	COG1522	sequence-specific DNA binding
PspR84_17890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PspR84_17895	COG0022	dehydrogenase e1 component
PspR84_17905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspR84_17910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PspR84_17970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PspR84_18030	COG0583	DNA-binding transcription factor activity
PspR84_18040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_18045	COG0446	pyridine nucleotide-disulphide oxidoreductase
PspR84_18050	COG3383	formate dehydrogenase (NAD+) activity
PspR84_18080	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_18090	COG0583	DNA-binding transcription factor activity
PspR84_18100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PspR84_18110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspR84_18155	COG0534	Mate efflux family protein
PspR84_18170	COG0745	RESPONSE REGULATOR receiver
PspR84_18170	COG3706	GGDEF domain
PspR84_18180	COG3474	cytochrome
PspR84_18185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_18190	COG0697	spore germination
PspR84_18195	COG4977	sequence-specific DNA binding
PspR84_18205	COG0659	secondary active sulfate transmembrane transporter activity
PspR84_18215	COG0456	acetyltransferase
PspR84_18230	COG1335	isochorismatase
PspR84_18245	COG0494	nUDIX hydrolase
PspR84_18250	COG3469	chitinase activity
PspR84_18265	COG0454	-acetyltransferase
PspR84_18300	COG2920	part of a sulfur-relay system
PspR84_18305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PspR84_18310	COG0435	Glutathione S-transferase
PspR84_18315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PspR84_18315	COG1648	precorrin-2 dehydrogenase activity
PspR84_18320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PspR84_18325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PspR84_18330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PspR84_18335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PspR84_18340	COG1674	ftsk spoiiie
PspR84_18345	COG0492	ferredoxin-NADP+ reductase activity
PspR84_18350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PspR84_18355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PspR84_18360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PspR84_18365	COG0542	response to heat
PspR84_18370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PspR84_18375	COG1278	Cold shock
PspR84_18400	COG0482	sulfurtransferase activity
PspR84_18405	COG2915	High frequency lysogenization protein hflD homolog
PspR84_18415	COG2850	peptidyl-arginine hydroxylation
PspR84_18420	COG2153	protein acetylation
PspR84_18435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspR84_18440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspR84_18445	COG0649	NAD binding
PspR84_18445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspR84_18460	COG1034	ATP synthesis coupled electron transport
PspR84_18465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PspR84_18470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspR84_18480	COG0713	ATP synthesis coupled electron transport
PspR84_18560	COG0642	Histidine kinase
PspR84_18585	COG0395	ABC-type sugar transport system, permease component
PspR84_18595	COG3842	ATPase activity
PspR84_18600	COG3842	ATPase activity
PspR84_18605	COG3284	Transcriptional regulator
PspR84_18620	COG0215	cysteine-tRNA ligase activity
PspR84_18625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PspR84_18635	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspR84_18640	COG2814	Major facilitator Superfamily
PspR84_18645	COG1566	PFAM secretion protein HlyD family protein
PspR84_18655	COG1846	Transcriptional regulator
PspR84_18665	COG0784	Response regulator, receiver
PspR84_18665	COG2205	protein histidine kinase activity
PspR84_18680	COG2197	response regulator
PspR84_18690	COG3121	Chaperone
PspR84_18695	COG3188	usher protein
PspR84_18700	COG2911	Protein conserved in bacteria
PspR84_18705	COG0729	surface antigen
PspR84_18715	COG0708	Exodeoxyribonuclease III
PspR84_18720	COG2885	chlorophyll binding
PspR84_18725	COG1960	acyl-CoA dehydrogenase activity
PspR84_18735	COG0789	Transcriptional regulator
PspR84_18745	COG0318	PFAM AMP-dependent synthetase and ligase
PspR84_18750	COG1960	acyl-CoA dehydrogenase activity
PspR84_18755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PspR84_18760	COG1024	Enoyl-CoA hydratase
PspR84_18770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PspR84_18785	COG2866	Carboxypeptidase
PspR84_18790	COG2814	Major facilitator Superfamily
PspR84_18795	COG3038	cytochrome b561
PspR84_18850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PspR84_18860	COG0217	transcriptional regulatory protein
PspR84_18865	COG3501	Rhs element vgr protein
PspR84_18870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_18880	COG0583	DNA-binding transcription factor activity
PspR84_18885	COG0583	DNA-binding transcription factor activity
PspR84_18890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PspR84_18895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PspR84_18900	COG3038	cytochrome b561
PspR84_18910	COG1902	pentaerythritol trinitrate reductase activity
PspR84_18910	COG0446	pyridine nucleotide-disulphide oxidoreductase
PspR84_18940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspR84_18945	COG0776	regulation of translation
PspR84_18950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PspR84_18955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PspR84_18960	COG0740	serine-type endopeptidase activity
PspR84_18965	COG0544	peptidyl-prolyl cis-trans isomerase activity
PspR84_18990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PspR84_18995	COG1686	Belongs to the peptidase S11 family
PspR84_19020	COG1253	flavin adenine dinucleotide binding
PspR84_19030	COG0583	DNA-binding transcription factor activity
PspR84_19040	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PspR84_19050	COG3132	Protein of unknown function, DUF480
PspR84_19060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PspR84_19090	COG0583	DNA-binding transcription factor activity
PspR84_19095	COG0697	spore germination
PspR84_19105	COG2186	Transcriptional regulator
PspR84_19155	COG0730	response to heat
PspR84_19160	COG2814	Major facilitator Superfamily
PspR84_19175	COG0656	L-ascorbic acid biosynthetic process
PspR84_19185	COG0417	DNA replication proofreading
PspR84_19190	COG0517	IMP dehydrogenase activity
PspR84_19220	COG4166	transmembrane transport
PspR84_19225	COG4174	ABC transporter (Permease)
PspR84_19230	COG4239	(ABC) transporter, permease
PspR84_19235	COG4172	Belongs to the ABC transporter superfamily
PspR84_19285	COG0717	Belongs to the dCTP deaminase family
PspR84_19290	COG0113	porphobilinogen synthase activity
PspR84_19295	COG0625	glutathione transferase activity
PspR84_19305	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PspR84_19325	COG3248	Nucleoside-binding outer membrane protein
PspR84_19385	COG2056	Na+-H+ antiporter family
PspR84_19390	COG0840	transmembrane signaling receptor activity
PspR84_19395	COG2205	protein histidine kinase activity
PspR84_19400	COG0745	RESPONSE REGULATOR receiver
PspR84_19420	COG0720	synthase
PspR84_19430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PspR84_19435	COG0402	S-adenosylhomocysteine deaminase activity
PspR84_19440	COG3501	Rhs element vgr protein
PspR84_19455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PspR84_19460	COG2223	nitrite transmembrane transporter activity
PspR84_19465	COG4772	TonB-dependent receptor
PspR84_19475	COG1595	DNA-templated transcription, initiation
PspR84_19515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspR84_19525	COG4251	negative regulation of phosphorylation
PspR84_19525	COG2203	Gaf domain
PspR84_19525	COG5001	Diguanylate cyclase
PspR84_19525	COG3706	GGDEF domain
PspR84_19530	COG0235	Class ii aldolase
PspR84_19540	COG0583	DNA-binding transcription factor activity
PspR84_19575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspR84_19595	COG5001	Diguanylate cyclase
PspR84_19595	COG3300	MHYT domain
PspR84_19600	COG0840	transmembrane signaling receptor activity
PspR84_19605	COG1522	sequence-specific DNA binding
PspR84_19615	COG2423	ornithine cyclodeaminase activity
PspR84_19620	COG1113	amino acid transport
PspR84_19670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PspR84_19680	COG1968	undecaprenyl-diphosphatase activity
PspR84_19695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PspR84_19705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PspR84_19730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PspR84_19775	COG3206	protein involved in exopolysaccharide biosynthesis
PspR84_19775	COG0489	protein tyrosine kinase activity
PspR84_19790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PspR84_19810	COG2853	Lipoprotein
PspR84_19830	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PspR84_19830	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PspR84_19850	COG4591	ABC-type transport system involved in lipoprotein release permease component
PspR84_19855	COG1136	(ABC) transporter
PspR84_19860	COG4591	ABC-type transport system involved in lipoprotein release permease component
PspR84_19870	COG0584	glycerophosphoryl diester phosphodiesterase
PspR84_19875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspR84_19880	COG1477	protein flavinylation
PspR84_19895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PspR84_19905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PspR84_19910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PspR84_19915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PspR84_19960	COG0183	Belongs to the thiolase family
PspR84_19965	COG1024	Enoyl-CoA hydratase
PspR84_19965	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspR84_19980	COG0589	response to stress
PspR84_19990	COG0741	lytic transglycosylase activity
PspR84_19995	COG1132	(ABC) transporter
PspR84_20005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspR84_20015	COG0425	Belongs to the sulfur carrier protein TusA family
PspR84_20020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PspR84_20045	COG1397	ADP-ribosylglycohydrolase
PspR84_20055	COG0789	Transcriptional regulator
PspR84_20060	COG0778	Nitroreductase
PspR84_20070	COG3655	Transcriptional regulator
PspR84_20080	COG0768	penicillin binding
PspR84_20130	COG4221	oxidoreductase activity
PspR84_20160	COG0431	NADPH-dependent FMN reductase
PspR84_20165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspR84_20175	COG3829	transcription factor binding
PspR84_20195	COG0596	Alpha beta hydrolase
PspR84_20200	COG0583	DNA-binding transcription factor activity
PspR84_20205	COG0066	3-isopropylmalate dehydratase activity
PspR84_20210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PspR84_20240	COG1121	(ABC) transporter
PspR84_20245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PspR84_20270	COG0642	Histidine kinase
PspR84_20275	COG0745	RESPONSE REGULATOR receiver
PspR84_20290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PspR84_20325	COG1309	transcriptional regulator
PspR84_20340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PspR84_20345	COG1960	acyl-CoA dehydrogenase activity
PspR84_20350	COG1024	Enoyl-CoA hydratase
PspR84_20350	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspR84_20365	COG3123	guanosine phosphorylase activity
PspR84_20370	COG0633	Ferredoxin
PspR84_20370	COG3217	Mosc domain protein beta barrel domain protein
PspR84_20385	COG3851	Histidine kinase
PspR84_20390	COG2197	response regulator
PspR84_20395	COG1597	lipid kinase activity
PspR84_20410	COG0521	Mo-molybdopterin cofactor biosynthetic process
PspR84_20415	COG0746	molybdenum cofactor guanylyltransferase activity
PspR84_20425	COG0564	pseudouridine synthase activity
PspR84_20445	COG0004	ammonium transporteR
PspR84_20465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PspR84_20475	COG2197	response regulator
PspR84_20480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_20480	COG2205	protein histidine kinase activity
PspR84_20485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PspR84_20490	COG1956	GAF domain-containing protein
PspR84_20500	COG0784	Response regulator, receiver
PspR84_20500	COG2205	protein histidine kinase activity
PspR84_20500	COG5002	protein histidine kinase activity
PspR84_20505	COG1846	Transcriptional regulator
PspR84_20510	COG0386	Belongs to the glutathione peroxidase family
PspR84_20515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspR84_20520	COG0436	Aminotransferase
PspR84_20525	COG0501	Belongs to the peptidase M48B family
PspR84_20530	COG0500	methyltransferase
PspR84_20535	COG3384	dioxygenase
PspR84_20545	COG1024	Enoyl-CoA hydratase
PspR84_20555	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PspR84_20560	COG3214	Protein conserved in bacteria
PspR84_20570	COG0583	DNA-binding transcription factor activity
PspR84_20580	COG0583	DNA-binding transcription factor activity
PspR84_20585	COG1846	Transcriptional regulator
PspR84_20590	COG1764	response to oxidative stress
PspR84_20600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PspR84_20615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspR84_20635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PspR84_20650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PspR84_20665	COG1376	ErfK ybiS ycfS ynhG family protein
PspR84_20680	COG4181	ATPase activity
PspR84_20685	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PspR84_20700	COG2259	Doxx family
PspR84_20705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PspR84_20710	COG0084	hydrolase, TatD family'
PspR84_20750	COG2205	protein histidine kinase activity
PspR84_20755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PspR84_20765	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PspR84_20790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspR84_20795	COG4221	oxidoreductase activity
PspR84_20800	COG1555	photosystem II stabilization
PspR84_20845	COG1215	transferase activity, transferring glycosyl groups
PspR84_20850	COG1696	Membrane protein involved in D-alanine export
PspR84_20865	COG0529	Catalyzes the synthesis of activated sulfate
PspR84_20870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PspR84_20885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PspR84_20905	COG0776	regulation of translation
PspR84_20920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PspR84_20925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PspR84_20930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PspR84_20940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PspR84_20950	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PspR84_20955	COG0402	S-adenosylhomocysteine deaminase activity
PspR84_20960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PspR84_20965	COG0546	phosphoglycolate phosphatase activity
PspR84_20970	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_20975	COG3706	GGDEF domain
PspR84_20985	COG5002	protein histidine kinase activity
PspR84_20985	COG5001	Diguanylate cyclase
PspR84_21005	COG0271	Belongs to the BolA IbaG family
PspR84_21015	COG0114	fumarate hydratase activity
PspR84_21020	COG0697	spore germination
PspR84_21030	COG0183	Belongs to the thiolase family
PspR84_21035	COG2326	polyphosphate kinase activity
PspR84_21040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_21040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PspR84_21055	COG0367	asparagine synthase
PspR84_21060	COG0189	ligase activity
PspR84_21060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PspR84_21070	COG3089	Belongs to the UPF0270 family
PspR84_21075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspR84_21080	COG1742	UPF0060 membrane protein
PspR84_21095	COG1368	sulfuric ester hydrolase activity
PspR84_21115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_21120	COG2885	chlorophyll binding
PspR84_21150	COG2207	Transcriptional regulator
PspR84_21155	COG1064	alcohol dehydrogenase
PspR84_21160	COG1414	Transcriptional regulator
PspR84_21165	COG2271	Major facilitator Superfamily
PspR84_21170	COG4948	Mandelate Racemase Muconate Lactonizing
PspR84_21175	COG0800	Aldolase
PspR84_21180	COG3734	2-keto-3-deoxy-galactonokinase
PspR84_21210	COG1418	mRNA catabolic process
PspR84_21245	COG1397	ADP-ribosylglycohydrolase
PspR84_21250	COG2188	Transcriptional regulator
PspR84_21255	COG1172	Belongs to the binding-protein-dependent transport system permease family
PspR84_21260	COG1129	ABC transporter
PspR84_21265	COG1879	ABC-type sugar transport system periplasmic component
PspR84_21270	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_21280	COG2186	Transcriptional regulator
PspR84_21295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PspR84_21305	COG0084	hydrolase, TatD family'
PspR84_21320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PspR84_21325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PspR84_21335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspR84_21340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspR84_21355	COG0416	fatty acid biosynthetic process
PspR84_21360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PspR84_21365	COG1399	metal-binding, possibly nucleic acid-binding protein
PspR84_21370	COG0424	maF-like protein
PspR84_21375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PspR84_21375	COG0616	signal peptide processing
PspR84_21380	COG0546	phosphoglycolate phosphatase activity
PspR84_21395	COG1530	ribonuclease E activity
PspR84_21400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PspR84_21405	COG3608	succinylglutamate desuccinylase aspartoacylase
PspR84_21405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PspR84_21420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PspR84_21425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PspR84_21430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PspR84_21435	COG2835	tetraacyldisaccharide 4'-kinase activity
PspR84_21440	COG1663	tetraacyldisaccharide 4'-kinase activity
PspR84_21445	COG0848	biopolymer transport protein
PspR84_21450	COG0811	peptide transport
PspR84_21455	COG2333	competence protein COMEC
PspR84_21455	COG0658	competence protein
PspR84_21465	COG0842	Transport permease protein
PspR84_21470	COG1131	(ABC) transporter
PspR84_21475	COG0625	glutathione transferase activity
PspR84_21485	COG1960	acyl-CoA dehydrogenase activity
PspR84_21500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PspR84_21550	COG0840	transmembrane signaling receptor activity
PspR84_21555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_21560	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_21565	COG2130	NADP-dependent
PspR84_21570	COG0284	orotidine-5'-phosphate decarboxylase activity
PspR84_21580	COG2205	protein histidine kinase activity
PspR84_21590	COG0628	permease
PspR84_21615	COG1022	Amp-dependent synthetase and ligase
PspR84_21630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PspR84_21635	COG4771	TonB-dependent receptor
PspR84_21645	COG5002	protein histidine kinase activity
PspR84_21645	COG2205	protein histidine kinase activity
PspR84_21645	COG0784	Response regulator, receiver
PspR84_21650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PspR84_21665	COG3122	Protein conserved in bacteria
PspR84_21670	COG3956	TIGRFAM MazG family protein
PspR84_21675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PspR84_21680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PspR84_21700	COG5002	protein histidine kinase activity
PspR84_21700	COG0784	Response regulator, receiver
PspR84_21700	COG2205	protein histidine kinase activity
PspR84_21705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspR84_21725	COG3118	belongs to the thioredoxin family
PspR84_21730	COG1393	Belongs to the ArsC family
PspR84_21745	COG2818	Glycosylase
PspR84_21750	COG0037	tRNA processing
PspR84_21760	COG3091	SprT-like family
PspR84_21765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PspR84_21775	COG1917	Cupin 2, conserved barrel domain protein
PspR84_21775	COG4977	sequence-specific DNA binding
PspR84_21780	COG2205	protein histidine kinase activity
PspR84_21785	COG0745	RESPONSE REGULATOR receiver
PspR84_21805	COG2205	protein histidine kinase activity
PspR84_21810	COG0745	RESPONSE REGULATOR receiver
PspR84_21820	COG1749	Flagellar hook protein flgE
PspR84_21825	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PspR84_21830	COG1558	bacterial-type flagellum-dependent cell motility
PspR84_21835	COG1815	bacterial-type flagellum-dependent cell motility
PspR84_21840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PspR84_21845	COG0784	Response regulator, receiver
PspR84_21845	COG0835	chemotaxis
PspR84_21855	COG2747	anti-sigma28 factor FlgM
PspR84_21865	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PspR84_21870	COG0477	Major facilitator Superfamily
PspR84_21950	COG2239	Acts as a magnesium transporter
PspR84_21980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspR84_21985	COG0527	aspartate kinase activity
PspR84_21990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PspR84_21995	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
PspR84_22000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PspR84_22005	COG2988	succinylglutamate desuccinylase activity
PspR84_22015	COG3724	N-succinylarginine dihydrolase activity
PspR84_22020	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_22035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspR84_22065	COG4215	(ABC) transporter
PspR84_22070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_22075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspR84_22085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PspR84_22120	COG2207	Transcriptional regulator
PspR84_22165	COG0504	CTP synthase activity
PspR84_22170	COG2329	Antibiotic biosynthesis monooxygenase
PspR84_22180	COG0584	glycerophosphoryl diester phosphodiesterase
PspR84_22210	COG0306	phosphate transporter
PspR84_22215	COG0583	DNA-binding transcription factor activity
PspR84_22220	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_22230	COG0583	DNA-binding transcription factor activity
PspR84_22235	COG4941	Belongs to the sigma-70 factor family
PspR84_22240	COG3795	YCII-related domain
PspR84_22250	COG0456	acetyltransferase
PspR84_22275	COG0436	Aminotransferase
PspR84_22285	COG3265	gluconokinase activity
PspR84_22290	COG1609	Transcriptional regulator
PspR84_22295	COG0583	DNA-binding transcription factor activity
PspR84_22305	COG2271	Major facilitator Superfamily
PspR84_22330	COG1595	DNA-templated transcription, initiation
PspR84_22350	COG0242	peptide deformylase activity
PspR84_22355	COG1295	ribonuclease BN
PspR84_22360	COG3237	CsbD-like
PspR84_22370	COG0318	PFAM AMP-dependent synthetase and ligase
PspR84_22375	COG0318	PFAM AMP-dependent synthetase and ligase
PspR84_22380	COG2267	carboxylic ester hydrolase activity
PspR84_22385	COG2030	dehydratase
PspR84_22395	COG3530	Putative quorum-sensing-regulated virulence factor
PspR84_22400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PspR84_22410	COG0800	Aldolase
PspR84_22425	COG1737	Transcriptional regulator
PspR84_22430	COG0676	glucose-6-phosphate 1-epimerase activity
PspR84_22445	COG0395	ABC-type sugar transport system, permease component
PspR84_22455	COG1653	transport
PspR84_22465	COG2205	protein histidine kinase activity
PspR84_22470	COG0745	RESPONSE REGULATOR receiver
PspR84_22495	COG3712	iron ion homeostasis
PspR84_22500	COG4771	TonB-dependent receptor
PspR84_22510	COG2832	Protein of unknown function (DUF454)
PspR84_22515	COG0840	transmembrane signaling receptor activity
PspR84_22520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PspR84_22545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PspR84_22565	COG0509	glycine decarboxylation via glycine cleavage system
PspR84_22570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspR84_22570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspR84_22575	COG1760	l-serine dehydratase
PspR84_22580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PspR84_22585	COG1278	Cold shock
PspR84_22595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PspR84_22605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PspR84_22610	COG0602	queuosine metabolic process
PspR84_22615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PspR84_22620	COG2885	chlorophyll binding
PspR84_22625	COG0823	Involved in the tonB-independent uptake of proteins
PspR84_22645	COG0824	Thioesterase
PspR84_22650	COG2255	four-way junction helicase activity
PspR84_22655	COG0632	four-way junction helicase activity
PspR84_22660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PspR84_22665	COG0217	transcriptional regulatory protein
PspR84_22670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PspR84_22685	COG0783	Belongs to the Dps family
PspR84_22695	COG2900	Belongs to the SlyX family
PspR84_22710	COG0668	transmembrane transport
PspR84_22715	COG1666	GTP binding
PspR84_22725	COG4191	Histidine kinase
PspR84_22725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_22730	COG2096	Adenosyltransferase
PspR84_22735	COG0494	nUDIX hydrolase
PspR84_22745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PspR84_22750	COG0653	protein targeting
PspR84_22760	COG0433	COG0433 Predicted ATPase
PspR84_22770	COG0438	transferase activity, transferring glycosyl groups
PspR84_22770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PspR84_22800	COG2925	Exonuclease
PspR84_22825	COG0714	Associated with various cellular activities
PspR84_22870	COG0469	pyruvate kinase activity
PspR84_22875	COG1024	Enoyl-CoA hydratase
PspR84_22880	COG0633	Ferredoxin
PspR84_22880	COG0543	2 iron, 2 sulfur cluster binding
PspR84_22885	COG3706	GGDEF domain
PspR84_22910	COG4191	Histidine kinase
PspR84_22925	COG0477	Major facilitator Superfamily
PspR84_22950	COG2207	Transcriptional regulator
PspR84_22965	COG0583	DNA-binding transcription factor activity
PspR84_22970	COG2910	NAD(P)H-binding
PspR84_22980	COG0583	DNA-binding transcription factor activity
PspR84_22995	COG0477	Major facilitator Superfamily
PspR84_23015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_23020	COG0583	DNA-binding transcription factor activity
PspR84_23035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PspR84_23065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspR84_23070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PspR84_23080	COG3642	lipopolysaccharide core region biosynthetic process
PspR84_23090	COG0642	Histidine kinase
PspR84_23105	COG0459	protein refolding
PspR84_23110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PspR84_23125	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_23130	COG0489	protein tyrosine kinase activity
PspR84_23135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PspR84_23135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PspR84_23145	COG2878	Part of a membrane complex involved in electron transport
PspR84_23155	COG4659	FMN binding
PspR84_23165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PspR84_23170	COG2197	response regulator
PspR84_23180	COG0137	argininosuccinate synthase activity
PspR84_23190	COG0418	dihydroorotase activity
PspR84_23195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspR84_23200	COG0450	alkyl hydroperoxide reductase
PspR84_23205	COG2906	2 iron, 2 sulfur cluster binding
PspR84_23215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PspR84_23220	COG0243	molybdopterin cofactor binding
PspR84_23230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PspR84_23235	COG3842	ATPase activity
PspR84_23245	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PspR84_23255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PspR84_23275	COG0477	Major facilitator Superfamily
PspR84_23310	COG0814	amino acid
PspR84_23320	COG0765	amino acid transport
PspR84_23325	COG0765	amino acid transport
PspR84_23330	COG1126	abc transporter atp-binding protein
PspR84_23355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspR84_23375	COG0583	DNA-binding transcription factor activity
PspR84_23385	COG1280	lysine exporter protein (LysE YggA)
PspR84_23395	COG0531	amino acid
PspR84_23405	COG2197	response regulator
PspR84_23410	COG0069	glutamate synthase activity
PspR84_23425	COG1113	amino acid transport
PspR84_23475	COG1695	Transcriptional regulator
PspR84_23480	COG2375	cellular response to nickel ion
PspR84_23490	COG4628	conserved protein (DUF2132)
PspR84_23520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PspR84_23535	COG4106	trans-aconitate 2-methyltransferase activity
PspR84_23540	COG0500	methyltransferase
PspR84_23545	COG0590	tRNA wobble adenosine to inosine editing
PspR84_23560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PspR84_23560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PspR84_23570	COG0366	Alpha amylase catalytic
PspR84_23575	COG1263	PTS System
PspR84_23575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PspR84_23580	COG2188	Transcriptional regulator
PspR84_23595	COG0519	Catalyzes the synthesis of GMP from XMP
PspR84_23595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PspR84_23620	COG1570	exodeoxyribonuclease VII activity
PspR84_23625	COG0739	heme binding
PspR84_23635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PspR84_23645	COG0436	Aminotransferase
PspR84_23650	COG1160	GTP binding
PspR84_23665	COG0124	histidyl-tRNA synthetase
PspR84_23670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PspR84_23685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PspR84_23690	COG0105	UTP biosynthetic process
PspR84_23695	COG2975	iron-sulfur cluster assembly
PspR84_23700	COG0633	Ferredoxin
PspR84_23705	COG0443	Heat shock 70 kDa protein
PspR84_23710	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PspR84_23715	COG0316	Belongs to the HesB IscA family
PspR84_23725	COG1104	cysteine desulfurase activity
PspR84_23750	COG3134	Outer membrane lipoprotein
PspR84_23765	COG1862	Preprotein translocase
PspR84_23770	COG0343	queuine tRNA-ribosyltransferase activity
PspR84_23775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PspR84_23860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspR84_23865	COG0583	DNA-binding transcription factor activity
PspR84_23890	COG0109	protoheme IX farnesyltransferase activity
PspR84_23900	COG1845	cytochrome c oxidase, subunit III
PspR84_23905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PspR84_23910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PspR84_23920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PspR84_23925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PspR84_23925	COG1017	nitric oxide dioxygenase activity
PspR84_23930	COG3604	Transcriptional regulator
PspR84_23985	COG5002	protein histidine kinase activity
PspR84_24000	COG2203	Gaf domain
PspR84_24000	COG4251	negative regulation of phosphorylation
PspR84_24000	COG5001	Diguanylate cyclase
PspR84_24000	COG3706	GGDEF domain
PspR84_24005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PspR84_24010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PspR84_24025	COG1181	Belongs to the D-alanine--D-alanine ligase family
PspR84_24030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PspR84_24035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PspR84_24040	COG0772	Belongs to the SEDS family
PspR84_24045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PspR84_24050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PspR84_24055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PspR84_24060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PspR84_24075	COG0275	rRNA processing
PspR84_24080	COG2001	Belongs to the MraZ family
PspR84_24100	COG0792	nuclease activity
PspR84_24105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PspR84_24110	COG2823	Periplasmic or secreted lipoprotein
PspR84_24115	COG2969	positive regulation of protein catabolic process
PspR84_24120	COG0625	glutathione transferase activity
PspR84_24125	COG2857	Cytochrome c1
PspR84_24130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PspR84_24135	COG0723	plastoquinol--plastocyanin reductase activity
PspR84_24140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PspR84_24145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PspR84_24150	COG0667	Aldo Keto reductase
PspR84_24155	COG1960	acyl-CoA dehydrogenase activity
PspR84_24165	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PspR84_24170	COG0180	Tryptophanyl-tRNA synthetase
PspR84_24190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PspR84_24215	COG0318	PFAM AMP-dependent synthetase and ligase
PspR84_24230	COG1280	lysine exporter protein (LysE YggA)
PspR84_24235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspR84_24240	COG2813	Specifically methylates the guanine in position
PspR84_24245	COG2119	membrane
PspR84_24255	COG0501	Belongs to the peptidase M48B family
PspR84_24260	COG0840	transmembrane signaling receptor activity
PspR84_24265	COG2135	peptidase activity
PspR84_24325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PspR84_24335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PspR84_24340	COG1090	epimerase
PspR84_24345	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PspR84_24360	COG0789	Transcriptional regulator
PspR84_24365	COG0415	Belongs to the DNA photolyase family
PspR84_24375	COG4221	oxidoreductase activity
PspR84_24380	COG0493	'glutamate synthase
PspR84_24390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PspR84_24410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PspR84_24415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PspR84_24425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PspR84_24430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PspR84_24440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PspR84_24445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PspR84_24455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PspR84_24460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PspR84_24465	COG0193	aminoacyl-tRNA hydrolase activity
PspR84_24475	COG3220	belongs to the UPF0276 family
PspR84_24485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PspR84_24490	COG2814	Major facilitator Superfamily
PspR84_24500	COG0625	glutathione transferase activity
PspR84_24505	COG1942	4-Oxalocrotonate Tautomerase
PspR84_24520	COG0583	DNA-binding transcription factor activity
PspR84_24525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PspR84_24530	COG0066	3-isopropylmalate dehydratase activity
PspR84_24540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PspR84_24545	COG2223	nitrite transmembrane transporter activity
PspR84_24570	COG0405	Gamma-glutamyltransferase
PspR84_24575	COG4680	protein conserved in bacteria
PspR84_24590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PspR84_24605	COG0477	Major facilitator Superfamily
PspR84_24615	COG2031	fatty acid transporter
PspR84_24620	COG0443	Heat shock 70 kDa protein
PspR84_24645	COG0288	reversible hydration of carbon dioxide
PspR84_24655	COG0456	acetyltransferase
PspR84_24680	COG3008	intermembrane lipid transfer
PspR84_24685	COG2995	paraquat-inducible protein a
PspR84_24690	COG2995	paraquat-inducible protein a
PspR84_24725	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PspR84_24730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PspR84_24735	COG1183	phosphatidylcholine synthase activity
PspR84_24740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PspR84_24750	COG0028	Belongs to the TPP enzyme family
PspR84_24770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PspR84_24800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PspR84_24805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PspR84_24810	COG4558	Periplasmic binding protein
PspR84_24820	COG1489	DNA binding
PspR84_24825	COG0436	Aminotransferase
PspR84_24830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PspR84_24835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PspR84_24840	COG4191	Histidine kinase
PspR84_24845	COG2204	response regulator
PspR84_24860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PspR84_24865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PspR84_24875	COG0166	Belongs to the GPI family
PspR84_24880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspR84_24890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspR84_24905	COG2823	Periplasmic or secreted lipoprotein
PspR84_24930	COG0237	dephospho-CoA kinase activity
PspR84_24935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PspR84_24965	COG1252	NADH dehydrogenase
PspR84_25000	COG0542	response to heat
PspR84_25035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_25065	COG4969	Belongs to the N-Me-Phe pilin family
PspR84_25075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PspR84_25080	COG1047	Peptidyl-prolyl cis-trans
PspR84_25085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PspR84_25090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PspR84_25095	COG0196	riboflavin kinase activity
PspR84_25110	COG0268	Binds directly to 16S ribosomal RNA
PspR84_25115	COG3045	CreA protein
PspR84_25120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PspR84_25125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PspR84_25130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PspR84_25135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PspR84_25140	COG0142	geranyltranstransferase activity
PspR84_25145	COG2824	Alkylphosphonate utilization operon protein PhnA
PspR84_25150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PspR84_25155	COG0545	Peptidyl-prolyl cis-trans isomerase
PspR84_25165	COG2862	Uncharacterized protein family, UPF0114
PspR84_25180	COG1067	ATP-dependent peptidase activity
PspR84_25200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspR84_25210	COG0488	(ABC) transporter
PspR84_25220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PspR84_25240	COG0523	cobalamin synthesis protein
PspR84_25245	COG2879	small protein
PspR84_25250	COG1966	Carbon starvation protein
PspR84_25275	COG1970	mechanosensitive ion channel activity
PspR84_25285	COG2197	response regulator
PspR84_25290	COG2813	Specifically methylates the guanine in position
PspR84_25300	COG1294	oxidase, subunit
PspR84_25305	COG1271	oxidase subunit
PspR84_25335	COG2252	PERMEase
PspR84_25340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PspR84_25355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PspR84_25360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PspR84_25365	COG1309	transcriptional regulator
PspR84_25375	COG0477	Major facilitator Superfamily
PspR84_25390	COG0673	inositol 2-dehydrogenase activity
PspR84_25400	COG1053	succinate dehydrogenase
PspR84_25405	COG0656	L-ascorbic acid biosynthetic process
PspR84_25410	COG2321	neutral zinc metallopeptidase
PspR84_25425	COG1946	Acyl-CoA thioesterase
PspR84_25435	COG0123	including yeast histone deacetylase and acetoin utilization protein
PspR84_25445	COG0513	Belongs to the DEAD box helicase family
PspR84_25450	COG0697	spore germination
PspR84_25455	COG1522	sequence-specific DNA binding
PspR84_25460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspR84_25460	COG1199	ATP-dependent helicase activity
PspR84_25470	COG3416	Protein conserved in bacteria
PspR84_25490	COG1643	Atp-dependent helicase
PspR84_25500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PspR84_25510	COG1522	sequence-specific DNA binding
PspR84_25525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PspR84_25530	COG1960	acyl-CoA dehydrogenase activity
PspR84_25545	COG0352	thiamine-phosphate diphosphorylase activity
PspR84_25550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PspR84_25565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PspR84_25570	COG1702	phosphate starvation-inducible protein PhoH
PspR84_25575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PspR84_25580	COG4535	Mg2 and Co2 transporter CorC
PspR84_25585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PspR84_25600	COG0495	leucyl-tRNA aminoacylation
PspR84_25620	COG2951	lytic endotransglycosylase activity
PspR84_25625	COG1619	proteins homologs of microcin C7 resistance protein MccF
PspR84_25630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PspR84_25635	COG0321	lipoyl(octanoyl) transferase activity
PspR84_25640	COG2921	Belongs to the UPF0250 family
PspR84_25645	COG1686	Belongs to the peptidase S11 family
PspR84_25655	COG2951	lytic endotransglycosylase activity
PspR84_25660	COG0772	Belongs to the SEDS family
PspR84_25665	COG0768	penicillin binding
PspR84_25670	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PspR84_25680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PspR84_25685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PspR84_25690	COG2094	Belongs to the DNA glycosylase MPG family
PspR84_25695	COG0586	Pfam SNARE associated Golgi protein
PspR84_25735	COG1346	cytolysis
PspR84_25755	COG0702	epimerase
PspR84_25770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PspR84_25775	COG3284	Transcriptional regulator
PspR84_25780	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_25785	COG0531	amino acid
PspR84_25790	COG4303	Ethanolamine ammonia lyase large subunit
PspR84_25795	COG4302	ethanolamine ammonia-lyase activity
PspR84_25800	COG0456	acetyltransferase
PspR84_25805	COG0586	Pfam SNARE associated Golgi protein
PspR84_25810	COG3228	Belongs to the MtfA family
PspR84_25815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PspR84_25825	COG0582	viral genome integration into host DNA
PspR84_25915	COG3706	GGDEF domain
PspR84_25925	COG4676	Protein conserved in bacteria
PspR84_25930	COG5445	Predicted secreted protein (DUF2300)
PspR84_25945	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
PspR84_25950	COG4676	Protein conserved in bacteria
PspR84_25955	COG1722	exodeoxyribonuclease VII activity
PspR84_25960	COG0142	geranyltranstransferase activity
PspR84_25965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PspR84_25970	COG4206	TonB-dependent receptor
PspR84_25975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PspR84_25985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PspR84_25995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PspR84_26000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PspR84_26005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PspR84_26010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PspR84_26025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PspR84_26025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PspR84_26040	COG2264	protein methyltransferase activity
PspR84_26045	COG3118	belongs to the thioredoxin family
PspR84_26075	COG3047	cAMP biosynthetic process
PspR84_26080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspR84_26090	COG1201	RNA secondary structure unwinding
PspR84_26095	COG0668	transmembrane transport
PspR84_26105	COG3568	Endonuclease Exonuclease Phosphatase
PspR84_26110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspR84_26115	COG0392	lysyltransferase activity
PspR84_26130	COG4753	response regulator
PspR84_26130	COG2207	Transcriptional regulator
PspR84_26135	COG1335	isochorismatase
PspR84_26140	COG3789	protein conserved in bacteria
PspR84_26155	COG3766	membrane
PspR84_26165	COG0754	glutathionylspermidine amidase activity
PspR84_26170	COG0629	single-stranded DNA binding
PspR84_26175	COG2814	Major facilitator Superfamily
PspR84_26180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PspR84_26185	COG2193	ferroxidase activity
PspR84_26195	COG0203	ribosomal protein L17
PspR84_26200	COG0202	RNA polymerase activity
PspR84_26205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PspR84_26210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PspR84_26215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PspR84_26220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PspR84_26230	COG0200	Binds to the 23S rRNA
PspR84_26235	COG1841	ribosomal large subunit assembly
PspR84_26240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PspR84_26245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PspR84_26250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PspR84_26255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PspR84_26260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PspR84_26265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PspR84_26270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PspR84_26275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PspR84_26280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PspR84_26285	COG0255	Belongs to the universal ribosomal protein uL29 family
PspR84_26290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PspR84_26295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PspR84_26305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PspR84_26310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PspR84_26315	COG0089	rRNA binding
PspR84_26320	COG0088	Forms part of the polypeptide exit tunnel
PspR84_26325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PspR84_26330	COG0051	transcription antitermination factor activity, RNA binding
PspR84_26335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PspR84_26340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PspR84_26345	COG0049	tRNA binding
PspR84_26350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PspR84_26355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PspR84_26360	COG0085	RNA polymerase activity
PspR84_26365	COG0222	ribosome binding
PspR84_26370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PspR84_26375	COG0081	regulation of translation
PspR84_26380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PspR84_26400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PspR84_26425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PspR84_26465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PspR84_26470	COG0739	heme binding
PspR84_26475	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PspR84_26480	COG0316	Belongs to the HesB IscA family
PspR84_26485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PspR84_26505	COG1028	Short-chain dehydrogenase reductase Sdr
PspR84_26510	COG0537	adenosine 5'-monophosphoramidase activity
PspR84_26515	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PspR84_26520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PspR84_26525	COG1765	OsmC-like protein
PspR84_26540	COG0134	indole-3-glycerol-phosphate synthase activity
PspR84_26545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PspR84_26550	COG0512	Glutamine amidotransferase of anthranilate synthase
PspR84_26560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PspR84_26565	COG0546	phosphoglycolate phosphatase activity
PspR84_26570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PspR84_26575	COG1454	alcohol dehydrogenase
PspR84_26585	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspR84_26595	COG3842	ATPase activity
PspR84_26600	COG2197	response regulator
PspR84_26615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PspR84_26620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PspR84_26625	COG3178	'Phosphotransferase
PspR84_26630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PspR84_26635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspR84_26640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PspR84_26645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PspR84_26650	COG2967	ApaG domain
PspR84_26655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PspR84_26660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PspR84_26665	COG2766	serine protein kinase
PspR84_26670	COG2718	Belongs to the UPF0229 family
PspR84_26675	COG2719	SpoVR family
PspR84_26680	COG0617	tRNA 3'-terminal CCA addition
PspR84_26690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PspR84_26695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PspR84_26700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PspR84_26705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PspR84_26710	COG0358	DNA primase activity
PspR84_26715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PspR84_26730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PspR84_26745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspR84_26750	COG1025	Belongs to the peptidase M16 family
PspR84_26760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PspR84_26765	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PspR84_26775	COG0535	radical SAM domain protein
PspR84_26790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspR84_26795	COG0583	DNA-binding transcription factor activity
PspR84_26800	COG1960	acyl-CoA dehydrogenase activity
PspR84_26805	COG1960	acyl-CoA dehydrogenase activity
PspR84_26810	COG3706	GGDEF domain
PspR84_26815	COG1960	acyl-CoA dehydrogenase activity
PspR84_26835	COG1073	alpha beta
PspR84_26835	COG2226	methyltransferase
PspR84_26840	COG0156	8-amino-7-oxononanoate synthase activity
PspR84_26845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PspR84_26855	COG3585	molybdate ion transport
PspR84_26855	COG2005	Transcriptional regulator
PspR84_26865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PspR84_26880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PspR84_26885	COG2204	response regulator
PspR84_26895	COG2176	DNA-directed DNA polymerase activity
PspR84_26900	COG1595	DNA-templated transcription, initiation
PspR84_26905	COG3712	iron ion homeostasis
PspR84_26910	COG4774	siderophore transport
PspR84_26935	COG4452	Inner membrane protein CreD
PspR84_26940	COG2205	protein histidine kinase activity
PspR84_26945	COG0745	RESPONSE REGULATOR receiver
PspR84_26950	COG4067	protein conserved in archaea
PspR84_26950	COG0189	ligase activity
PspR84_26955	COG0204	Acyl-transferase
PspR84_26965	COG1595	DNA-templated transcription, initiation
PspR84_26975	COG1063	alcohol dehydrogenase
PspR84_27005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PspR84_27025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PspR84_27025	COG1017	nitric oxide dioxygenase activity
PspR84_27030	COG4638	Rieske (2fe-2S)
PspR84_27040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PspR84_27045	COG0247	lactate metabolic process
PspR84_27045	COG2181	nitrate reductase activity
PspR84_27050	COG1902	pentaerythritol trinitrate reductase activity
PspR84_27050	COG0446	pyridine nucleotide-disulphide oxidoreductase
PspR84_27090	COG3246	L-lysine catabolic process to acetate
PspR84_27095	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspR84_27120	COG1760	l-serine dehydratase
PspR84_27130	COG4176	ABC-type proline glycine betaine transport system permease component
PspR84_27135	COG3448	diguanylate cyclase activity
PspR84_27135	COG4175	Glycine betaine
PspR84_27140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PspR84_27150	COG1309	transcriptional regulator
PspR84_27155	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_27160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PspR84_27170	COG0312	modulator of DNA gyrase
PspR84_27175	COG0477	Major facilitator Superfamily
PspR84_27180	COG0513	Belongs to the DEAD box helicase family
PspR84_27185	COG2081	HI0933 family
PspR84_27190	COG1289	transmembrane transporter activity
PspR84_27200	COG2153	protein acetylation
PspR84_27210	COG1451	nucleotide metabolic process
PspR84_27270	COG0126	phosphoglycerate kinase activity
PspR84_27275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PspR84_27285	COG0640	Transcriptional regulator
PspR84_27290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PspR84_27295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PspR84_27325	COG2814	Major facilitator Superfamily
PspR84_27335	COG2116	formate transmembrane transporter activity
PspR84_27345	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PspR84_27350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PspR84_27360	COG0513	Belongs to the DEAD box helicase family
PspR84_27365	COG2353	YceI-like domain
PspR84_27370	COG3038	cytochrome b561
PspR84_27390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PspR84_27395	COG1272	protein, Hemolysin III
PspR84_27435	COG3052	prosthetic group binding
PspR84_27440	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PspR84_27485	COG0189	ligase activity
PspR84_27495	COG1678	Uncharacterized ACR, COG1678
PspR84_27500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PspR84_27505	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PspR84_27510	COG0540	Belongs to the ATCase OTCase family
PspR84_27515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PspR84_27525	COG0791	NLP P60 protein
PspR84_27550	COG1872	DUF167
PspR84_27555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspR84_27560	COG2813	Specifically methylates the guanine in position
PspR84_27560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspR84_27570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PspR84_27575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PspR84_27585	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
PspR84_27590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PspR84_27595	COG2022	thiamine diphosphate biosynthetic process
PspR84_27605	COG2363	Small membrane protein
PspR84_27610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PspR84_27620	COG2177	Part of the ABC transporter FtsEX involved in
PspR84_27625	COG2884	Cell division ATP-binding protein ftsE
PspR84_27630	COG0552	protein localization to endoplasmic reticulum
PspR84_27640	COG0612	Peptidase, M16
PspR84_27645	COG0612	Peptidase, M16
PspR84_27650	COG0742	ribosomal rna small subunit methyltransferase
PspR84_27655	COG0429	hydrolase of the alpha beta-hydrolase fold
PspR84_27685	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PspR84_27690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PspR84_27695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PspR84_27705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PspR84_27715	COG0693	protein deglycase activity
PspR84_27720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspR84_27735	COG2814	Major facilitator Superfamily
PspR84_27740	COG0129	dihydroxy-acid dehydratase activity
PspR84_27765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PspR84_27780	COG1840	ABC-type Fe3 transport system, periplasmic component
PspR84_27785	COG1178	ABC-type Fe3 transport system permease component
PspR84_27790	COG3842	ATPase activity
PspR84_27795	COG0583	DNA-binding transcription factor activity
PspR84_27805	COG0789	Transcriptional regulator
PspR84_27810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PspR84_27815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PspR84_27820	COG0730	response to heat
PspR84_27830	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PspR84_27835	COG0494	nUDIX hydrolase
PspR84_27850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PspR84_27855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PspR84_27860	COG3204	pilus organization
PspR84_27865	COG3204	pilus organization
PspR84_27870	COG0179	Fumarylacetoacetate (FAA) hydrolase
PspR84_27875	COG0277	FAD linked oxidase domain protein
PspR84_27885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspR84_27895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_27900	COG1683	Conserved Protein
PspR84_27940	COG1177	transmembrane transport
PspR84_27945	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspR84_27950	COG3842	ATPase activity
PspR84_27970	COG0174	glutamine synthetase
PspR84_27975	COG0174	glutamine synthetase
PspR84_27990	COG1116	anion transmembrane transporter activity
PspR84_27995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspR84_28000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspR84_28005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspR84_28010	COG0431	NADPH-dependent FMN reductase
PspR84_28015	COG0450	alkyl hydroperoxide reductase
PspR84_28025	COG4521	taurine ABC transporter
PspR84_28030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PspR84_28030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PspR84_28045	COG1522	sequence-specific DNA binding
PspR84_28065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspR84_28065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspR84_28070	COG0509	glycine decarboxylation via glycine cleavage system
PspR84_28075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PspR84_28080	COG1178	ABC-type Fe3 transport system permease component
PspR84_28090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PspR84_28100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PspR84_28105	COG0006	proline dipeptidase activity
PspR84_28110	COG3079	Belongs to the UPF0149 family
PspR84_28130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PspR84_28170	COG2271	Major facilitator Superfamily
PspR84_28185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PspR84_28205	COG2186	Transcriptional regulator
PspR84_28210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_28215	COG0765	amino acid transport
PspR84_28225	COG1126	abc transporter atp-binding protein
PspR84_28230	COG0248	Ppx GppA phosphatase
PspR84_28235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PspR84_28245	COG0586	Pfam SNARE associated Golgi protein
PspR84_28250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PspR84_28255	COG1671	Belongs to the UPF0178 family
PspR84_28260	COG0672	)-iron permease
PspR84_28290	COG1280	lysine exporter protein (LysE YggA)
PspR84_28300	COG0488	(ABC) transporter
PspR84_28325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PspR84_28345	COG0181	hydroxymethylbilane synthase activity
PspR84_28355	COG0165	Argininosuccinate lyase
PspR84_28360	COG0625	glutathione transferase activity
PspR84_28375	COG3072	Adenylate cyclase
PspR84_28380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspR84_28390	COG1965	Belongs to the frataxin family
PspR84_28400	COG0019	diaminopimelate decarboxylase activity
PspR84_28405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PspR84_28415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PspR84_28420	COG1011	Hydrolase
PspR84_28430	COG0432	Pfam Uncharacterised protein family UPF0047
PspR84_28435	COG0004	ammonium transporteR
PspR84_28440	COG0347	Belongs to the P(II) protein family
PspR84_28455	COG3093	addiction module antidote protein HigA
PspR84_28465	COG0606	chelatase, subunit chli
PspR84_28480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PspR84_28490	COG0210	DNA helicase
PspR84_28615	COG0840	transmembrane signaling receptor activity
PspR84_28620	COG0583	DNA-binding transcription factor activity
PspR84_28625	COG0534	Mate efflux family protein
PspR84_28640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PspR84_28645	COG0427	acetyl-CoA hydrolase
PspR84_28660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PspR84_28670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_28675	COG1522	sequence-specific DNA binding
PspR84_28685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspR84_28695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspR84_28700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspR84_28710	COG1012	belongs to the aldehyde dehydrogenase family
PspR84_28720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PspR84_28725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PspR84_28730	COG0747	negative chemotaxis
PspR84_28735	COG2003	Belongs to the UPF0758 family
PspR84_28740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PspR84_28745	COG0756	dUTP diphosphatase activity
PspR84_28750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PspR84_28755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PspR84_28775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PspR84_28780	COG0708	Exodeoxyribonuclease III
PspR84_28785	COG0786	glutamate:sodium symporter activity
PspR84_28795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PspR84_28800	COG1561	YicC-like family, N-terminal region
PspR84_28805	COG0194	GDP metabolic process
PspR84_28810	COG1758	RNA polymerase activity
PspR84_28815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PspR84_28840	COG0848	biopolymer transport protein
PspR84_28850	COG0583	DNA-binding transcription factor activity
PspR84_28855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PspR84_28975	COG3501	Rhs element vgr protein
PspR84_28980	COG2815	serine threonine protein kinase
PspR84_28980	COG0515	serine threonine protein kinase
PspR84_29095	COG3161	chorismate lyase activity
PspR84_29100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PspR84_29120	COG1253	flavin adenine dinucleotide binding
PspR84_29125	COG0739	heme binding
PspR84_29135	COG0704	Plays a role in the regulation of phosphate uptake
PspR84_29140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PspR84_29145	COG0573	inorganic phosphate transmembrane transporter activity
PspR84_29170	COG0477	Major facilitator Superfamily
PspR84_29175	COG1607	acyl-coa hydrolase
PspR84_29205	COG0583	DNA-binding transcription factor activity
PspR84_29210	COG1027	Aspartate ammonia-lyase
PspR84_29215	COG1115	amino acid carrier protein
PspR84_29220	COG0252	asparaginase activity
PspR84_29265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspR84_29270	COG0765	amino acid transport
PspR84_29290	COG5016	pyruvate
PspR84_29290	COG0511	ligase activity, forming carbon-carbon bonds
PspR84_29295	COG0439	Biotin carboxylase
PspR84_29300	COG0583	DNA-binding transcription factor activity
PspR84_29320	COG0210	DNA helicase
PspR84_29335	COG4651	solute:proton antiporter activity
PspR84_29335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PspR84_29340	COG1607	acyl-coa hydrolase
PspR84_29345	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PspR84_29355	COG0523	cobalamin synthesis protein
PspR84_29380	COG0860	N-Acetylmuramoyl-L-alanine amidase
PspR84_29385	COG1469	GTP cyclohydrolase I activity
PspR84_29390	COG1121	(ABC) transporter
PspR84_29400	COG0803	Belongs to the bacterial solute-binding protein 9 family
PspR84_29410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PspR84_29420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspR84_29425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PspR84_29435	COG3220	belongs to the UPF0276 family
PspR84_29445	COG2217	Heavy metal translocating P-type atpase
PspR84_29465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspR84_29470	COG1522	sequence-specific DNA binding
PspR84_29490	COG2226	methyltransferase
PspR84_29495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PspR84_29495	COG2755	lipolytic protein G-D-S-L family
PspR84_29540	COG0438	transferase activity, transferring glycosyl groups
PspR84_29550	COG1017	nitric oxide dioxygenase activity
PspR84_29550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PspR84_29555	COG0625	glutathione transferase activity
PspR84_29560	COG0583	DNA-binding transcription factor activity
PspR84_29565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PspR84_29570	COG1349	DNA-binding transcription factor activity
PspR84_29575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PspR84_29580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PspR84_29585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PspR84_29590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PspR84_29595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PspR84_29600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PspR84_29605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PspR84_29615	COG0356	it plays a direct role in the translocation of protons across the membrane
PspR84_29620	COG3312	ion transport
PspR84_29625	COG1475	DNA binding
PspR84_29630	COG1192	Involved in chromosome partitioning
PspR84_29635	COG0357	Ribosomal RNA small subunit methyltransferase G
PspR84_29640	COG0445	tRNA wobble uridine modification
PspR84_29645	COG1595	DNA-templated transcription, initiation
PspR84_29650	COG3712	iron ion homeostasis
PspR84_29660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PspR84_29665	COG0706	membrane insertase activity
PspR84_29670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PspR84_29675	COG0594	ribonuclease P activity
PspR84_29680	COG0230	Belongs to the bacterial ribosomal protein bL34 family