locus-tag	class	description
PspS19_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PspS19_00010	COG0592	DNA-directed DNA polymerase activity
PspS19_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PspS19_00020	COG0187	DNA topoisomerase II activity
PspS19_00040	COG5002	protein histidine kinase activity
PspS19_00055	COG0751	glycine-tRNA ligase activity
PspS19_00060	COG0752	glycyl-tRNA synthetase alpha subunit
PspS19_00065	COG2818	Glycosylase
PspS19_00080	COG0569	domain protein
PspS19_00085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PspS19_00090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PspS19_00095	COG0242	peptide deformylase activity
PspS19_00100	COG0758	DNA mediated transformation
PspS19_00105	COG0009	L-threonylcarbamoyladenylate synthase
PspS19_00115	COG0408	coproporphyrinogen oxidase activity
PspS19_00120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PspS19_00135	COG3119	arylsulfatase activity
PspS19_00140	COG0583	DNA-binding transcription factor activity
PspS19_00150	COG0159	tryptophan synthase activity
PspS19_00170	COG3360	Dodecin
PspS19_00180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_00185	COG1764	response to oxidative stress
PspS19_00215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PspS19_00220	COG0339	signal peptide processing
PspS19_00225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PspS19_00255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PspS19_00260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PspS19_00265	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PspS19_00280	COG3346	SURF1 family
PspS19_00295	COG0109	protoheme IX farnesyltransferase activity
PspS19_00310	COG2011	ABC-type metal ion transport system permease component
PspS19_00315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PspS19_00330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PspS19_00335	COG1121	(ABC) transporter
PspS19_00340	COG0735	belongs to the Fur family
PspS19_00345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PspS19_00365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PspS19_00390	COG3706	GGDEF domain
PspS19_00390	COG0745	RESPONSE REGULATOR receiver
PspS19_00395	COG3023	N-Acetylmuramoyl-L-alanine amidase
PspS19_00400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PspS19_00405	COG5002	protein histidine kinase activity
PspS19_00410	COG2204	response regulator
PspS19_00430	COG1301	dicarboxylic acid transport
PspS19_00435	COG0700	Nucleoside recognition
PspS19_00450	COG1127	ABC transporter
PspS19_00455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PspS19_00465	COG0612	Peptidase, M16
PspS19_00470	COG1283	sodium-dependent phosphate transmembrane transporter activity
PspS19_00475	COG0861	Integral membrane protein TerC family
PspS19_00480	COG2851	Citrate transporter
PspS19_00520	COG0427	acetyl-CoA hydrolase
PspS19_00525	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PspS19_00530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PspS19_00535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PspS19_00540	COG0583	DNA-binding transcription factor activity
PspS19_00545	COG1960	acyl-CoA dehydrogenase activity
PspS19_00585	COG3712	iron ion homeostasis
PspS19_00595	COG0840	transmembrane signaling receptor activity
PspS19_00600	COG1802	Transcriptional regulator
PspS19_00610	COG5001	Diguanylate cyclase
PspS19_00610	COG3300	MHYT domain
PspS19_00625	COG1538	Outer membrane efflux protein
PspS19_00630	COG2274	protein secretion by the type I secretion system
PspS19_00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_00650	COG2814	Major facilitator Superfamily
PspS19_00665	COG0330	HflC and HflK could
PspS19_00690	COG1289	transmembrane transporter activity
PspS19_00700	COG1566	PFAM secretion protein HlyD family protein
PspS19_00715	COG5339	Protein conserved in bacteria
PspS19_00720	COG0457	Tetratricopeptide repeat
PspS19_00725	COG0726	polysaccharide deacetylase
PspS19_00725	COG1649	PFAM Uncharacterised BCR, COG1649
PspS19_00730	COG1215	transferase activity, transferring glycosyl groups
PspS19_00760	COG1960	acyl-CoA dehydrogenase activity
PspS19_00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_00785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PspS19_00795	COG0455	bacterial-type flagellum organization
PspS19_00815	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_00820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PspS19_00825	COG0745	RESPONSE REGULATOR receiver
PspS19_00845	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PspS19_00855	COG4208	sulfate ABC transporter
PspS19_00860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PspS19_00865	COG1280	lysine exporter protein (LysE YggA)
PspS19_00870	COG2197	response regulator
PspS19_00900	COG3550	peptidyl-serine autophosphorylation
PspS19_00950	COG0765	amino acid transport
PspS19_00955	COG0765	amino acid transport
PspS19_00960	COG1126	abc transporter atp-binding protein
PspS19_00970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PspS19_00985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PspS19_01000	COG2011	ABC-type metal ion transport system permease component
PspS19_01005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PspS19_01010	COG1464	Belongs to the NlpA lipoprotein family
PspS19_01050	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PspS19_01055	COG1045	serine acetyltransferase
PspS19_01065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PspS19_01075	COG2175	clavaminate synthase activity
PspS19_01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspS19_01085	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PspS19_01090	COG4521	taurine ABC transporter
PspS19_01095	COG2918	glutathione biosynthetic process
PspS19_01105	COG2183	response to ionizing radiation
PspS19_01110	COG0745	RESPONSE REGULATOR receiver
PspS19_01120	COG0189	ligase activity
PspS19_01125	COG4067	protein conserved in archaea
PspS19_01125	COG0189	ligase activity
PspS19_01130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PspS19_01140	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PspS19_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PspS19_01165	COG0514	ATP-dependent DNA helicase (RecQ)
PspS19_01170	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspS19_01170	COG1024	Enoyl-CoA hydratase
PspS19_01175	COG0824	Thioesterase
PspS19_01185	COG0243	molybdopterin cofactor binding
PspS19_01190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PspS19_01195	COG0583	DNA-binding transcription factor activity
PspS19_01200	COG1652	LysM domain
PspS19_01205	COG1011	Hydrolase
PspS19_01210	COG0494	nUDIX hydrolase
PspS19_01215	COG1218	3'(2'),5'-bisphosphate nucleotidase
PspS19_01235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PspS19_01245	COG2957	Belongs to the agmatine deiminase family
PspS19_01330	COG0582	viral genome integration into host DNA
PspS19_01415	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PspS19_01420	COG1194	a g-specific adenine glycosylase
PspS19_01435	COG0131	Imidazoleglycerol-phosphate dehydratase
PspS19_01440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PspS19_01450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PspS19_01455	COG0107	imidazoleglycerol-phosphate synthase activity
PspS19_01470	COG2861	carbohydrate metabolic process
PspS19_01475	COG0793	Belongs to the peptidase S41A family
PspS19_01480	COG4942	peptidase
PspS19_01485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PspS19_01500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PspS19_01520	COG3852	Histidine kinase
PspS19_01540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PspS19_01540	COG0301	tRNA thio-modification
PspS19_01555	COG0058	SHG alpha-glucan phosphorylase activity
PspS19_01570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PspS19_01590	COG0402	S-adenosylhomocysteine deaminase activity
PspS19_01595	COG2188	Transcriptional regulator
PspS19_01610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PspS19_01615	COG2986	histidine ammonia-lyase
PspS19_01620	COG1113	amino acid transport
PspS19_01625	COG1228	amidohydrolase
PspS19_01635	COG0596	Alpha beta hydrolase
PspS19_01640	COG1490	D-aminoacyl-tRNA deacylase activity
PspS19_01645	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PspS19_01650	COG2943	transferase activity, transferring hexosyl groups
PspS19_01670	COG0765	amino acid transport
PspS19_01675	COG1126	abc transporter atp-binding protein
PspS19_01685	COG0840	transmembrane signaling receptor activity
PspS19_01700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PspS19_01705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PspS19_01710	COG0140	phosphoribosyl-ATP diphosphatase activity
PspS19_01715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PspS19_01720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PspS19_01730	COG2226	methyltransferase
PspS19_01750	COG1309	transcriptional regulator
PspS19_01775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PspS19_01780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PspS19_01790	COG0018	arginyl-trna synthetase
PspS19_01795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PspS19_01800	COG0254	rRNA binding
PspS19_01805	COG0281	malic enzyme
PspS19_01840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PspS19_01845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PspS19_01860	COG0067	glutamate synthase
PspS19_01860	COG0069	glutamate synthase activity
PspS19_01860	COG0070	glutamate synthase
PspS19_01865	COG0493	'glutamate synthase
PspS19_01870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PspS19_01880	COG2814	Major facilitator Superfamily
PspS19_01885	COG0583	DNA-binding transcription factor activity
PspS19_01915	COG4372	Transposase
PspS19_01920	COG3436	PFAM IS66 Orf2 family protein
PspS19_01935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspS19_01940	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_01985	COG2986	histidine ammonia-lyase
PspS19_02000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PspS19_02010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspS19_02015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspS19_02030	COG1192	Involved in chromosome partitioning
PspS19_02035	COG3118	belongs to the thioredoxin family
PspS19_02040	COG4680	protein conserved in bacteria
PspS19_02050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PspS19_02055	COG1196	nuclear chromosome segregation
PspS19_02055	COG3264	Mechanosensitive ion channel
PspS19_02060	COG3263	regulation of cellular component size
PspS19_02075	COG1960	acyl-CoA dehydrogenase activity
PspS19_02080	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PspS19_02080	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PspS19_02080	COG0506	proline dehydrogenase activity
PspS19_02085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PspS19_02090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PspS19_02095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspS19_02120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PspS19_02125	COG0859	PFAM glycosyl transferase family 9
PspS19_02130	COG0859	PFAM glycosyl transferase family 9
PspS19_02135	COG0438	transferase activity, transferring glycosyl groups
PspS19_02155	COG2192	nodulation
PspS19_02160	COG0438	transferase activity, transferring glycosyl groups
PspS19_02180	COG0438	transferase activity, transferring glycosyl groups
PspS19_02195	COG1132	(ABC) transporter
PspS19_02200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PspS19_02200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PspS19_02210	COG0667	Aldo Keto reductase
PspS19_02225	COG0583	DNA-binding transcription factor activity
PspS19_02230	COG1519	Transferase
PspS19_02240	COG3501	Rhs element vgr protein
PspS19_02275	COG1538	Outer membrane efflux protein
PspS19_02280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PspS19_02295	COG0494	nUDIX hydrolase
PspS19_02305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PspS19_02310	COG3150	esterase
PspS19_02345	COG0560	Phosphoserine phosphatase
PspS19_02345	COG3830	Belongs to the UPF0237 family
PspS19_02350	COG0688	phosphatidylethanolamine metabolic process
PspS19_02360	COG3944	biosynthesis protein
PspS19_02435	COG1360	Flagellar Motor Protein
PspS19_02455	COG1162	GTPase activity
PspS19_02460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PspS19_02465	COG2860	membrane
PspS19_02475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PspS19_02475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PspS19_02480	COG0802	atpase or kinase
PspS19_02485	COG0860	N-Acetylmuramoyl-L-alanine amidase
PspS19_02490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PspS19_02495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PspS19_02500	COG1923	regulation of RNA biosynthetic process
PspS19_02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PspS19_02510	COG0330	HflC and HflK could
PspS19_02515	COG0330	HflC and HflK could
PspS19_02520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PspS19_02525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PspS19_02530	COG0840	transmembrane signaling receptor activity
PspS19_02535	COG1178	ABC-type Fe3 transport system permease component
PspS19_02540	COG1840	ABC-type Fe3 transport system, periplasmic component
PspS19_02555	COG0557	exoribonuclease II activity
PspS19_02560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PspS19_02565	COG0360	Binds together with S18 to 16S ribosomal RNA
PspS19_02570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PspS19_02580	COG0359	binds to the 23S rRNA
PspS19_02585	COG0305	Participates in initiation and elongation during chromosome replication
PspS19_02590	COG1032	radical SAM domain protein
PspS19_02600	COG2308	Evidence 4 Homologs of previously reported genes of
PspS19_02600	COG2307	Protein conserved in bacteria
PspS19_02625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PspS19_02630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PspS19_02635	COG0583	DNA-binding transcription factor activity
PspS19_02640	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_02645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_02655	COG0559	Belongs to the binding-protein-dependent transport system permease family
PspS19_02670	COG0410	ABC transporter
PspS19_02675	COG4221	oxidoreductase activity
PspS19_02695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PspS19_02700	COG0830	nickel cation binding
PspS19_02705	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
PspS19_02720	COG2982	Protein involved in outer membrane biogenesis
PspS19_02730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PspS19_02735	COG0697	spore germination
PspS19_02770	COG0443	Heat shock 70 kDa protein
PspS19_02775	COG0484	heat shock protein binding
PspS19_02780	COG0789	Transcriptional regulator
PspS19_02795	COG0804	urea catabolic process
PspS19_02800	COG0832	Belongs to the urease beta subunit family
PspS19_02815	COG0831	urea catabolic process
PspS19_02820	COG0829	nickel cation binding
PspS19_02830	COG0411	ABC transporter
PspS19_02840	COG0559	Belongs to the binding-protein-dependent transport system permease family
PspS19_02845	COG0683	leucine binding
PspS19_02880	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PspS19_02885	COG3657	addiction module killer protein
PspS19_02895	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PspS19_02925	COG2095	MarC family integral membrane protein
PspS19_02950	COG0151	Belongs to the GarS family
PspS19_02955	COG0138	bifunctional purine biosynthesis protein purh
PspS19_02965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PspS19_02975	COG2264	protein methyltransferase activity
PspS19_03000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PspS19_03010	COG3706	GGDEF domain
PspS19_03010	COG0745	RESPONSE REGULATOR receiver
PspS19_03025	COG0023	Translation Initiation Factor
PspS19_03030	COG1166	arginine decarboxylase activity
PspS19_03035	COG3501	Rhs element vgr protein
PspS19_03045	COG0534	Mate efflux family protein
PspS19_03050	COG2373	Large extracellular alpha-helical protein
PspS19_03060	COG4953	penicillin-binding protein 1C
PspS19_03070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PspS19_03140	COG4964	Belongs to the GSP D family
PspS19_03175	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_03180	COG0183	Belongs to the thiolase family
PspS19_03200	COG2217	Heavy metal translocating P-type atpase
PspS19_03215	COG2814	Major facilitator Superfamily
PspS19_03225	COG0583	DNA-binding transcription factor activity
PspS19_03235	COG0477	Major facilitator Superfamily
PspS19_03240	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PspS19_03250	COG0387	Pfam Sodium calcium exchanger
PspS19_03265	COG0789	Transcriptional regulator
PspS19_03285	COG1129	ABC transporter
PspS19_03295	COG1309	transcriptional regulator
PspS19_03335	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PspS19_03340	COG1074	ATP-dependent DNA helicase activity
PspS19_03345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PspS19_03355	COG2199	diguanylate cyclase activity
PspS19_03360	COG2885	chlorophyll binding
PspS19_03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspS19_03395	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PspS19_03400	COG3483	tryptophan 2,3-dioxygenase activity
PspS19_03405	COG1113	amino acid transport
PspS19_03410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PspS19_03410	COG0543	2 iron, 2 sulfur cluster binding
PspS19_03415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
PspS19_03420	COG4638	Rieske (2fe-2S)
PspS19_03430	COG1522	sequence-specific DNA binding
PspS19_03440	COG1113	amino acid transport
PspS19_03445	COG0583	DNA-binding transcription factor activity
PspS19_03460	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspS19_03465	COG0583	DNA-binding transcription factor activity
PspS19_03480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PspS19_03490	COG0277	FAD linked oxidase domain protein
PspS19_03495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PspS19_03500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PspS19_03530	COG0840	transmembrane signaling receptor activity
PspS19_03555	COG3795	YCII-related domain
PspS19_03600	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PspS19_03610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PspS19_03615	COG0582	viral genome integration into host DNA
PspS19_03645	COG0247	lactate metabolic process
PspS19_03650	COG1620	l-lactate permease
PspS19_03655	COG2186	Transcriptional regulator
PspS19_03670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PspS19_03675	COG0733	neurotransmitter:sodium symporter activity
PspS19_03685	COG2914	Belongs to the UPF0125 (RnfH) family
PspS19_03690	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PspS19_03700	COG0497	DNA recombination
PspS19_03705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PspS19_03710	COG0443	Heat shock 70 kDa protein
PspS19_03715	COG0484	heat shock protein binding
PspS19_03720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PspS19_03725	COG0505	Belongs to the CarA family
PspS19_03730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PspS19_03735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspS19_03750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PspS19_03755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PspS19_03760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PspS19_03765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PspS19_03770	COG0149	triose-phosphate isomerase activity
PspS19_03775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PspS19_03790	COG0779	Required for maturation of 30S ribosomal subunits
PspS19_03795	COG0195	Participates in both transcription termination and antitermination
PspS19_03800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PspS19_03805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PspS19_03810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PspS19_03815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PspS19_03820	COG1185	polyribonucleotide nucleotidyltransferase activity
PspS19_03860	COG0084	hydrolase, TatD family'
PspS19_03865	COG1609	Transcriptional regulator
PspS19_03875	COG1105	Belongs to the carbohydrate kinase PfkB family
PspS19_03880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PspS19_03880	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PspS19_03880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PspS19_03895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PspS19_03900	COG4774	siderophore transport
PspS19_03905	COG3128	pkhd-type hydroxylase
PspS19_03925	COG0019	diaminopimelate decarboxylase activity
PspS19_03950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PspS19_03960	COG4608	Belongs to the ABC transporter superfamily
PspS19_03965	COG0444	Belongs to the ABC transporter superfamily
PspS19_03970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PspS19_03975	COG0601	transmembrane transport
PspS19_03980	COG0747	negative chemotaxis
PspS19_03990	COG0747	negative chemotaxis
PspS19_03995	COG0747	negative chemotaxis
PspS19_04010	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PspS19_04015	COG4178	(ABC) transporter
PspS19_04025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspS19_04035	COG2271	Major facilitator Superfamily
PspS19_04040	COG2721	sulfolactate sulfo-lyase activity
PspS19_04050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspS19_04065	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PspS19_04070	COG0154	amidase activity
PspS19_04075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PspS19_04080	COG1077	Cell shape determining protein MreB Mrl
PspS19_04085	COG1792	Involved in formation and maintenance of cell shape
PspS19_04095	COG0424	maF-like protein
PspS19_04100	COG1530	ribonuclease E activity
PspS19_04110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspS19_04115	COG0312	modulator of DNA gyrase
PspS19_04120	COG3028	Belongs to the UPF0307 family
PspS19_04125	COG0312	modulator of DNA gyrase
PspS19_04160	COG1660	Displays ATPase and GTPase activities
PspS19_04170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PspS19_04175	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PspS19_04180	COG1137	ATPase activity
PspS19_04185	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PspS19_04195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PspS19_04205	COG1127	ABC transporter
PspS19_04210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PspS19_04215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PspS19_04235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PspS19_04240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PspS19_04245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PspS19_04250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PspS19_04255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PspS19_04275	COG0175	sulfate reduction
PspS19_04285	COG0204	Acyl-transferase
PspS19_04290	COG0857	belongs to the CobB CobQ family
PspS19_04290	COG0280	phosphate acetyltransferase
PspS19_04305	COG0386	Belongs to the glutathione peroxidase family
PspS19_04320	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PspS19_04325	COG0492	ferredoxin-NADP+ reductase activity
PspS19_04340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PspS19_04345	COG0302	gtp cyclohydrolase
PspS19_04370	COG1366	Belongs to the anti-sigma-factor antagonist family
PspS19_04380	COG0583	DNA-binding transcription factor activity
PspS19_04385	COG1380	Effector of murein hydrolase LrgA
PspS19_04390	COG1346	cytolysis
PspS19_04405	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_04410	COG3023	N-Acetylmuramoyl-L-alanine amidase
PspS19_04425	COG2197	response regulator
PspS19_04435	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PspS19_04440	COG0179	Fumarylacetoacetate (FAA) hydrolase
PspS19_04465	COG1960	acyl-CoA dehydrogenase activity
PspS19_04485	COG0814	amino acid
PspS19_04490	COG1760	l-serine dehydratase
PspS19_04495	COG0583	DNA-binding transcription factor activity
PspS19_04505	COG0477	Major facilitator Superfamily
PspS19_04510	COG0583	DNA-binding transcription factor activity
PspS19_04540	COG4774	siderophore transport
PspS19_04545	COG2027	D-alanyl-D-alanine carboxypeptidase
PspS19_04550	COG3708	Transcriptional regulator
PspS19_04550	COG2207	Transcriptional regulator
PspS19_04555	COG0697	spore germination
PspS19_04565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspS19_04570	COG0583	DNA-binding transcription factor activity
PspS19_04590	COG1566	PFAM secretion protein HlyD family protein
PspS19_04605	COG2801	Transposase and inactivated derivatives
PspS19_04625	COG0300	oxidoreductase activity
PspS19_04635	COG0662	Cupin 2, conserved barrel domain protein
PspS19_04635	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PspS19_04650	COG1696	Membrane protein involved in D-alanine export
PspS19_04665	COG3420	alginic acid biosynthetic process
PspS19_04675	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PspS19_04680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_04685	COG1215	transferase activity, transferring glycosyl groups
PspS19_04695	COG3022	response to hydroperoxide
PspS19_04715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PspS19_04720	COG0315	cyclic pyranopterin monophosphate synthase activity
PspS19_04725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PspS19_04735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_04755	COG0513	Belongs to the DEAD box helicase family
PspS19_04765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_04770	COG4597	amino acid ABC transporter
PspS19_04775	COG0765	amino acid transport
PspS19_04780	COG1126	abc transporter atp-binding protein
PspS19_04785	COG2186	Transcriptional regulator
PspS19_04790	COG2807	transmembrane transport
PspS19_04800	COG2827	Endonuclease containing a URI domain
PspS19_04815	COG3081	Nucleoid-associated protein
PspS19_04825	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
PspS19_04830	COG0525	valine-tRNA ligase activity
PspS19_04850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PspS19_04855	COG0795	lipopolysaccharide-transporting ATPase activity
PspS19_04860	COG0795	lipopolysaccharide-transporting ATPase activity
PspS19_04865	COG0481	GTPase activity
PspS19_04870	COG0681	Belongs to the peptidase S26 family
PspS19_04875	COG0571	ribonuclease III activity
PspS19_04880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PspS19_04885	COG1381	Involved in DNA repair and RecF pathway recombination
PspS19_04890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PspS19_04895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PspS19_04900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PspS19_04900	COG0047	phosphoribosylformylglycinamidine synthase activity
PspS19_04905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PspS19_04915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PspS19_04915	COG1263	PTS System
PspS19_04915	COG2190	(PTS) system
PspS19_04920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PspS19_04920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PspS19_04925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PspS19_04930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PspS19_04935	COG2188	Transcriptional regulator
PspS19_04980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PspS19_04985	COG0477	Major facilitator Superfamily
PspS19_04990	COG4536	flavin adenine dinucleotide binding
PspS19_05000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PspS19_05005	COG0228	four-way junction DNA binding
PspS19_05010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PspS19_05015	COG0336	Belongs to the RNA methyltransferase TrmD family
PspS19_05020	COG0335	large ribosomal subunit rRNA binding
PspS19_05030	COG4974	Belongs to the 'phage' integrase family
PspS19_05050	COG2205	protein histidine kinase activity
PspS19_05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_05065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PspS19_05070	COG4681	YaeQ
PspS19_05080	COG1902	pentaerythritol trinitrate reductase activity
PspS19_05085	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PspS19_05095	COG3668	Plasmid stabilization system
PspS19_05105	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PspS19_05115	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_05120	COG1177	transmembrane transport
PspS19_05125	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_05130	COG3842	ATPase activity
PspS19_05135	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PspS19_05145	COG0583	DNA-binding transcription factor activity
PspS19_05165	COG0457	Tetratricopeptide repeat
PspS19_05165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PspS19_05170	COG0835	chemotaxis
PspS19_05180	COG2201	protein-glutamate methylesterase activity
PspS19_05185	COG4251	negative regulation of phosphorylation
PspS19_05185	COG5001	Diguanylate cyclase
PspS19_05185	COG3706	GGDEF domain
PspS19_05185	COG2203	Gaf domain
PspS19_05205	COG3501	Rhs element vgr protein
PspS19_05215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PspS19_05235	COG1073	alpha beta
PspS19_05245	COG2885	chlorophyll binding
PspS19_05260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PspS19_05265	COG0563	adenylate kinase activity
PspS19_05270	COG1214	PFAM Peptidase M22, glycoprotease
PspS19_05280	COG1801	Protein of unknown function DUF72
PspS19_05300	COG0742	ribosomal rna small subunit methyltransferase
PspS19_05310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_05330	COG2937	Belongs to the GPAT DAPAT family
PspS19_05350	COG2226	methyltransferase
PspS19_05355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PspS19_05370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PspS19_05380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PspS19_05385	COG2171	N-acyltransferase activity
PspS19_05390	COG1393	Belongs to the ArsC family
PspS19_05395	COG0025	NhaP-type Na H and K H
PspS19_05400	COG0436	Aminotransferase
PspS19_05405	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PspS19_05410	COG0024	Methionine aminopeptidase
PspS19_05415	COG0052	Belongs to the universal ribosomal protein uS2 family
PspS19_05420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PspS19_05425	COG0528	UMP kinase activity
PspS19_05430	COG0233	cytoplasmic translational termination
PspS19_05435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PspS19_05445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PspS19_05465	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspS19_05470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PspS19_05475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspS19_05480	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspS19_05485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PspS19_05490	COG0587	DNA-directed DNA polymerase activity
PspS19_05495	COG0825	malonyl-CoA metabolic process
PspS19_05500	COG0037	tRNA processing
PspS19_05505	COG0504	CTP synthase activity
PspS19_05510	COG0148	phosphopyruvate hydratase activity
PspS19_05520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PspS19_05530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
PspS19_05535	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PspS19_05540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PspS19_05545	COG0585	pseudouridine synthase activity
PspS19_05550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PspS19_05555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PspS19_05575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PspS19_05590	COG1546	Belongs to the CinA family
PspS19_05595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PspS19_05600	COG2137	regulation of response to DNA damage stimulus
PspS19_05640	COG0583	DNA-binding transcription factor activity
PspS19_05660	COG4807	Protein conserved in bacteria
PspS19_05665	COG1187	pseudouridine synthase activity
PspS19_05675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PspS19_05685	COG3158	transport of potassium into the cell
PspS19_05710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PspS19_05710	COG0392	lysyltransferase activity
PspS19_05725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PspS19_05735	COG0442	prolyl-tRNA aminoacylation
PspS19_05740	COG2211	Major facilitator Superfamily
PspS19_05755	COG1278	Cold shock
PspS19_05760	COG0717	Belongs to the dCTP deaminase family
PspS19_05785	COG4160	amino acid transport
PspS19_05790	COG4215	(ABC) transporter
PspS19_05800	COG2366	antibiotic biosynthetic process
PspS19_05810	COG0653	protein targeting
PspS19_05820	COG3012	SEC-C Motif Domain Protein
PspS19_05855	COG1199	ATP-dependent helicase activity
PspS19_05875	COG0259	pyridoxamine-phosphate oxidase activity
PspS19_05890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PspS19_05900	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PspS19_05950	COG2084	Dehydrogenase
PspS19_05960	COG2271	Major facilitator Superfamily
PspS19_05965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PspS19_05975	COG0306	phosphate transporter
PspS19_05985	COG1414	Transcriptional regulator
PspS19_05990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PspS19_05995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PspS19_06000	COG0183	Belongs to the thiolase family
PspS19_06005	COG0477	Major facilitator Superfamily
PspS19_06010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspS19_06035	COG0626	cystathionine gamma-synthase activity
PspS19_06040	COG1538	Outer membrane efflux protein
PspS19_06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_06070	COG1902	pentaerythritol trinitrate reductase activity
PspS19_06075	COG2814	Major facilitator Superfamily
PspS19_06120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspS19_06130	COG1704	LemA family
PspS19_06150	COG0697	spore germination
PspS19_06155	COG0693	protein deglycase activity
PspS19_06165	COG3422	double-strand break repair
PspS19_06170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspS19_06175	COG0235	Class ii aldolase
PspS19_06180	COG1396	sequence-specific DNA binding
PspS19_06190	COG1454	alcohol dehydrogenase
PspS19_06240	COG4106	trans-aconitate 2-methyltransferase activity
PspS19_06275	COG3706	GGDEF domain
PspS19_06290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PspS19_06340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspS19_06350	COG4215	(ABC) transporter
PspS19_06380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspS19_06395	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_06400	COG3724	N-succinylarginine dihydrolase activity
PspS19_06410	COG2988	succinylglutamate desuccinylase activity
PspS19_06415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PspS19_06420	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
PspS19_06425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PspS19_06430	COG0527	aspartate kinase activity
PspS19_06435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspS19_06465	COG2239	Acts as a magnesium transporter
PspS19_06535	COG2205	protein histidine kinase activity
PspS19_06545	COG0477	Major facilitator Superfamily
PspS19_06550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PspS19_06560	COG2747	anti-sigma28 factor FlgM
PspS19_06570	COG0835	chemotaxis
PspS19_06570	COG0784	Response regulator, receiver
PspS19_06575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PspS19_06585	COG1558	bacterial-type flagellum-dependent cell motility
PspS19_06590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PspS19_06605	COG4783	chaperone-mediated protein folding
PspS19_06610	COG0425	Belongs to the sulfur carrier protein TusA family
PspS19_06620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PspS19_06635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspS19_06640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PspS19_06645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PspS19_06650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PspS19_06780	COG0515	serine threonine protein kinase
PspS19_06795	COG1473	amidohydrolase
PspS19_06840	COG2807	transmembrane transport
PspS19_06850	COG0174	glutamine synthetase
PspS19_06855	COG2194	sulfuric ester hydrolase activity
PspS19_06870	COG3100	YcgL domain-containing protein
PspS19_06875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspS19_06885	COG2983	Belongs to the UPF0260 family
PspS19_06905	COG1403	HNH endonuclease
PspS19_06920	COG1770	oligopeptidase
PspS19_06930	COG0121	glutamine amidotransferase
PspS19_06940	COG0583	DNA-binding transcription factor activity
PspS19_06950	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PspS19_06955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PspS19_06960	COG1984	allophanate hydrolase subunit 2
PspS19_06970	COG0542	response to heat
PspS19_06980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PspS19_07000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PspS19_07005	COG1643	Atp-dependent helicase
PspS19_07035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PspS19_07050	COG1132	(ABC) transporter
PspS19_07075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspS19_07085	COG0668	transmembrane transport
PspS19_07090	COG0513	Belongs to the DEAD box helicase family
PspS19_07130	COG2996	Protein conserved in bacteria
PspS19_07135	COG0697	spore germination
PspS19_07140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PspS19_07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_07180	COG5001	Diguanylate cyclase
PspS19_07180	COG3300	MHYT domain
PspS19_07190	COG2832	Protein of unknown function (DUF454)
PspS19_07200	COG0514	ATP-dependent DNA helicase (RecQ)
PspS19_07205	COG1846	Transcriptional regulator
PspS19_07210	COG1752	Esterase of the alpha-beta hydrolase superfamily
PspS19_07225	COG2207	Transcriptional regulator
PspS19_07250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PspS19_07255	COG0778	Nitroreductase
PspS19_07275	COG0642	Histidine kinase
PspS19_07285	COG0745	RESPONSE REGULATOR receiver
PspS19_07290	COG2350	Protein conserved in bacteria
PspS19_07295	COG2917	probably involved in intracellular septation
PspS19_07300	COG0613	PHP domain protein
PspS19_07305	COG0009	L-threonylcarbamoyladenylate synthase
PspS19_07315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PspS19_07330	COG1113	amino acid transport
PspS19_07375	COG2154	pterin-4-alpha-carbinolamine dehydratase
PspS19_07385	COG3283	Transcriptional regulator of aromatic amino acids metabolism
PspS19_07390	COG4459	periplasmic nitrate reductase
PspS19_07395	COG3062	negative regulation of establishment of protein localization
PspS19_07400	COG0243	molybdopterin cofactor binding
PspS19_07410	COG3005	denitrification pathway
PspS19_07415	COG4786	Flagellar basal body rod
PspS19_07420	COG4786	Flagellar basal body rod
PspS19_07425	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PspS19_07430	COG1706	bacterial-type flagellum-dependent cell motility
PspS19_07440	COG1256	bacterial-type flagellum assembly
PspS19_07465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PspS19_07480	COG2204	response regulator
PspS19_07485	COG4191	Histidine kinase
PspS19_07490	COG2204	response regulator
PspS19_07495	COG1677	Flagellar hook-basal body complex protein FliE
PspS19_07530	COG0745	RESPONSE REGULATOR receiver
PspS19_07620	COG0455	bacterial-type flagellum organization
PspS19_07635	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PspS19_07640	COG2198	Histidine kinase
PspS19_07640	COG0643	Histidine kinase
PspS19_07645	COG2201	protein-glutamate methylesterase activity
PspS19_07650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PspS19_07660	COG1192	Involved in chromosome partitioning
PspS19_07670	COG0835	chemotaxis
PspS19_07700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PspS19_07710	COG4133	protoheme IX ABC transporter activity
PspS19_07730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PspS19_07735	COG1138	Cytochrome C-type biogenesis protein
PspS19_07745	COG3088	subunit of a heme lyase
PspS19_07770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PspS19_07775	COG4413	Urea transporter
PspS19_07780	COG0469	pyruvate kinase activity
PspS19_07790	COG2084	Dehydrogenase
PspS19_07795	COG3622	Belongs to the hyi family
PspS19_07800	COG3960	tartronate-semialdehyde synthase activity
PspS19_07815	COG1309	transcriptional regulator
PspS19_07820	COG2354	Protein conserved in bacteria
PspS19_07825	COG2853	Lipoprotein
PspS19_07845	COG2113	Glycine betaine
PspS19_07850	COG3162	membrane
PspS19_07855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PspS19_07880	COG2009	succinate dehydrogenase
PspS19_07885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PspS19_07890	COG1053	succinate dehydrogenase
PspS19_07895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PspS19_07910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspS19_07915	COG0045	succinate-CoA ligase (ADP-forming) activity
PspS19_07955	COG0326	Molecular chaperone. Has ATPase activity
PspS19_07965	COG1741	Belongs to the pirin family
PspS19_07990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PspS19_07995	COG0784	Response regulator, receiver
PspS19_07995	COG5002	protein histidine kinase activity
PspS19_07995	COG2205	protein histidine kinase activity
PspS19_08005	COG4771	TonB-dependent receptor
PspS19_08010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PspS19_08025	COG1022	Amp-dependent synthetase and ligase
PspS19_08045	COG0625	glutathione transferase activity
PspS19_08055	COG0628	permease
PspS19_08060	COG0284	orotidine-5'-phosphate decarboxylase activity
PspS19_08065	COG2130	NADP-dependent
PspS19_08070	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_08075	COG0436	Aminotransferase
PspS19_08080	COG0840	transmembrane signaling receptor activity
PspS19_08125	COG4215	(ABC) transporter
PspS19_08130	COG4160	amino acid transport
PspS19_08135	COG4598	ABC transporter
PspS19_08145	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PspS19_08170	COG0625	glutathione transferase activity
PspS19_08175	COG1131	(ABC) transporter
PspS19_08180	COG0842	Transport permease protein
PspS19_08190	COG2333	competence protein COMEC
PspS19_08190	COG0658	competence protein
PspS19_08195	COG0811	peptide transport
PspS19_08200	COG0848	biopolymer transport protein
PspS19_08205	COG1663	tetraacyldisaccharide 4'-kinase activity
PspS19_08210	COG2835	tetraacyldisaccharide 4'-kinase activity
PspS19_08215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PspS19_08220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PspS19_08225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PspS19_08235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PspS19_08245	COG1530	ribonuclease E activity
PspS19_08255	COG0546	phosphoglycolate phosphatase activity
PspS19_08260	COG0616	signal peptide processing
PspS19_08260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PspS19_08265	COG0424	maF-like protein
PspS19_08270	COG1399	metal-binding, possibly nucleic acid-binding protein
PspS19_08275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PspS19_08280	COG0416	fatty acid biosynthetic process
PspS19_08295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PspS19_08300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspS19_08310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PspS19_08315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PspS19_08325	COG0084	hydrolase, TatD family'
PspS19_08340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PspS19_08365	COG1064	alcohol dehydrogenase
PspS19_08370	COG2207	Transcriptional regulator
PspS19_08400	COG2885	chlorophyll binding
PspS19_08400	COG3047	cAMP biosynthetic process
PspS19_08405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_08435	COG2308	Evidence 4 Homologs of previously reported genes of
PspS19_08445	COG1305	Transglutaminase-like
PspS19_08455	COG0183	Belongs to the thiolase family
PspS19_08460	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspS19_08460	COG1024	Enoyl-CoA hydratase
PspS19_08465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PspS19_08465	COG0519	Catalyzes the synthesis of GMP from XMP
PspS19_08475	COG2197	response regulator
PspS19_08480	COG2205	protein histidine kinase activity
PspS19_08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_08485	COG2200	EAL domain
PspS19_08485	COG2203	Gaf domain
PspS19_08485	COG2199	diguanylate cyclase activity
PspS19_08495	COG2197	response regulator
PspS19_08500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_08500	COG2205	protein histidine kinase activity
PspS19_08505	COG0583	DNA-binding transcription factor activity
PspS19_08515	COG1335	isochorismatase
PspS19_08520	COG1335	isochorismatase
PspS19_08525	COG0668	transmembrane transport
PspS19_08545	COG2814	Major facilitator Superfamily
PspS19_08555	COG1595	DNA-templated transcription, initiation
PspS19_08565	COG4772	TonB-dependent receptor
PspS19_08570	COG2223	nitrite transmembrane transporter activity
PspS19_08580	COG0402	S-adenosylhomocysteine deaminase activity
PspS19_08585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PspS19_08590	COG0720	synthase
PspS19_08610	COG0745	RESPONSE REGULATOR receiver
PspS19_08615	COG2205	protein histidine kinase activity
PspS19_08620	COG0840	transmembrane signaling receptor activity
PspS19_08625	COG2056	Na+-H+ antiporter family
PspS19_08655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PspS19_08660	COG3132	Protein of unknown function, DUF480
PspS19_08670	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PspS19_08680	COG0583	DNA-binding transcription factor activity
PspS19_08690	COG1253	flavin adenine dinucleotide binding
PspS19_08705	COG1686	Belongs to the peptidase S11 family
PspS19_08710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PspS19_08735	COG0544	peptidyl-prolyl cis-trans isomerase activity
PspS19_08740	COG0740	serine-type endopeptidase activity
PspS19_08745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PspS19_08750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PspS19_08755	COG0776	regulation of translation
PspS19_08760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspS19_08770	COG0583	DNA-binding transcription factor activity
PspS19_08785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspS19_08790	COG0446	pyridine nucleotide-disulphide oxidoreductase
PspS19_08790	COG1902	pentaerythritol trinitrate reductase activity
PspS19_08800	COG3038	cytochrome b561
PspS19_08805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PspS19_08810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PspS19_08815	COG0583	DNA-binding transcription factor activity
PspS19_08820	COG0583	DNA-binding transcription factor activity
PspS19_08830	COG3501	Rhs element vgr protein
PspS19_08835	COG0217	transcriptional regulatory protein
PspS19_08855	COG0753	catalase activity
PspS19_08865	COG2866	Carboxypeptidase
PspS19_08875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PspS19_08890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PspS19_08895	COG1960	acyl-CoA dehydrogenase activity
PspS19_08900	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_08910	COG0789	Transcriptional regulator
PspS19_08920	COG1960	acyl-CoA dehydrogenase activity
PspS19_08935	COG0519	Catalyzes the synthesis of GMP from XMP
PspS19_08935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PspS19_08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_08985	COG0709	Synthesizes selenophosphate from selenide and ATP
PspS19_08990	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PspS19_08995	COG0701	Predicted permease
PspS19_09005	COG0625	glutathione transferase activity
PspS19_09015	COG0113	porphobilinogen synthase activity
PspS19_09030	COG1280	lysine exporter protein (LysE YggA)
PspS19_09090	COG3008	intermembrane lipid transfer
PspS19_09095	COG2995	paraquat-inducible protein a
PspS19_09105	COG0517	IMP dehydrogenase activity
PspS19_09115	COG0417	DNA replication proofreading
PspS19_09125	COG1177	transmembrane transport
PspS19_09130	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_09135	COG3842	ATPase activity
PspS19_09140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PspS19_09145	COG0174	glutamine synthetase
PspS19_09150	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_09155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_09160	COG1917	Cupin 2, conserved barrel domain protein
PspS19_09160	COG1396	sequence-specific DNA binding
PspS19_09165	COG2384	SAM-dependent methyltransferase
PspS19_09185	COG2202	Pas domain
PspS19_09185	COG2199	diguanylate cyclase activity
PspS19_09185	COG2200	EAL domain
PspS19_09190	COG0116	Belongs to the methyltransferase superfamily
PspS19_09190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspS19_09200	COG3038	cytochrome b561
PspS19_09210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PspS19_09215	COG1611	Belongs to the LOG family
PspS19_09235	COG2989	Protein conserved in bacteria
PspS19_09255	COG1737	Transcriptional regulator
PspS19_09275	COG4215	(ABC) transporter
PspS19_09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_09295	COG0730	response to heat
PspS19_09300	COG4106	trans-aconitate 2-methyltransferase activity
PspS19_09310	COG0697	spore germination
PspS19_09315	COG0583	DNA-binding transcription factor activity
PspS19_09330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PspS19_09335	COG0583	DNA-binding transcription factor activity
PspS19_09340	COG3209	COG3209 Rhs family protein
PspS19_09370	COG2885	chlorophyll binding
PspS19_09375	COG0708	Exodeoxyribonuclease III
PspS19_09385	COG0729	surface antigen
PspS19_09390	COG2911	Protein conserved in bacteria
PspS19_09395	COG1846	Transcriptional regulator
PspS19_09405	COG1566	PFAM secretion protein HlyD family protein
PspS19_09410	COG2814	Major facilitator Superfamily
PspS19_09420	COG2161	toxin-antitoxin pair type II binding
PspS19_09425	COG0454	-acetyltransferase
PspS19_09440	COG2135	peptidase activity
PspS19_09455	COG1960	acyl-CoA dehydrogenase activity
PspS19_09465	COG3829	transcription factor binding
PspS19_09475	COG0431	NADPH-dependent FMN reductase
PspS19_09505	COG1522	sequence-specific DNA binding
PspS19_09520	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_09540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_09555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PspS19_09555	COG2755	lipolytic protein G-D-S-L family
PspS19_09580	COG0583	DNA-binding transcription factor activity
PspS19_09585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspS19_09600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspS19_09635	COG1879	ABC-type sugar transport system periplasmic component
PspS19_09640	COG1129	ABC transporter
PspS19_09645	COG1172	Belongs to the binding-protein-dependent transport system permease family
PspS19_09650	COG1609	Transcriptional regulator
PspS19_09655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PspS19_09660	COG1869	D-ribose catabolic process
PspS19_09685	COG1278	Cold shock
PspS19_09700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PspS19_09705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PspS19_09710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PspS19_09715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PspS19_09720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PspS19_09725	COG0072	phenylalanine-tRNA ligase activity
PspS19_09730	COG0776	regulation of translation
PspS19_09935	COG2003	Belongs to the UPF0758 family
PspS19_09960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PspS19_10000	COG2894	cell division
PspS19_10055	COG0583	DNA-binding transcription factor activity
PspS19_10080	COG4774	siderophore transport
PspS19_10135	COG1294	oxidase, subunit
PspS19_10140	COG4890	Cyd operon protein YbgT
PspS19_10160	COG1335	isochorismatase
PspS19_10165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PspS19_10210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspS19_10245	COG0789	Transcriptional regulator
PspS19_10250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspS19_10260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspS19_10275	COG0183	Belongs to the thiolase family
PspS19_10285	COG2031	fatty acid transporter
PspS19_10300	COG4948	Mandelate Racemase Muconate Lactonizing
PspS19_10335	COG1473	amidohydrolase
PspS19_10345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PspS19_10360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PspS19_10375	COG0626	cystathionine gamma-synthase activity
PspS19_10385	COG1309	transcriptional regulator
PspS19_10410	COG3118	belongs to the thioredoxin family
PspS19_10415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PspS19_10415	COG0475	glutathione-regulated potassium exporter activity
PspS19_10420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspS19_10425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
PspS19_10435	COG2873	o-acetylhomoserine
PspS19_10450	COG1116	anion transmembrane transporter activity
PspS19_10455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspS19_10460	COG1116	anion transmembrane transporter activity
PspS19_10460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspS19_10495	COG2205	protein histidine kinase activity
PspS19_10495	COG0784	Response regulator, receiver
PspS19_10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_10525	COG4215	(ABC) transporter
PspS19_10530	COG4160	amino acid transport
PspS19_10540	COG2188	Transcriptional regulator
PspS19_10545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PspS19_10550	COG2986	histidine ammonia-lyase
PspS19_10560	COG2188	Transcriptional regulator
PspS19_10565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PspS19_10570	COG0251	oxidation-reduction process
PspS19_10575	COG1233	COG1233 Phytoene dehydrogenase and related
PspS19_10580	COG0840	transmembrane signaling receptor activity
PspS19_10585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PspS19_10595	COG0765	amino acid transport
PspS19_10605	COG3344	reverse transcriptase
PspS19_10610	COG2433	Pfam Transposase IS66
PspS19_10630	COG0582	viral genome integration into host DNA
PspS19_10645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PspS19_10660	COG1960	acyl-CoA dehydrogenase activity
PspS19_10675	COG2197	response regulator
PspS19_10710	COG0641	radical SAM
PspS19_10790	COG1621	beta-fructofuranosidase activity
PspS19_10795	COG3842	ATPase activity
PspS19_10810	COG1653	transport
PspS19_10825	COG4608	Belongs to the ABC transporter superfamily
PspS19_10830	COG0444	Belongs to the ABC transporter superfamily
PspS19_10835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PspS19_10840	COG0601	transmembrane transport
PspS19_10845	COG0747	negative chemotaxis
PspS19_10855	COG0006	proline dipeptidase activity
PspS19_10890	COG2814	Major facilitator Superfamily
PspS19_10905	COG1024	Enoyl-CoA hydratase
PspS19_10910	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_10915	COG1022	Amp-dependent synthetase and ligase
PspS19_10915	COG3320	Male sterility
PspS19_10925	COG1960	acyl-CoA dehydrogenase activity
PspS19_10955	COG1228	amidohydrolase
PspS19_10965	COG1073	alpha beta
PspS19_10985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PspS19_11025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspS19_11030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PspS19_11050	COG0583	DNA-binding transcription factor activity
PspS19_11055	COG3485	protocatechuate 3,4-dioxygenase
PspS19_11060	COG3485	protocatechuate 3,4-dioxygenase
PspS19_11075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspS19_11080	COG2814	Major facilitator Superfamily
PspS19_11095	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspS19_11105	COG0531	amino acid
PspS19_11140	COG0583	DNA-binding transcription factor activity
PspS19_11145	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_11155	COG3949	Membrane
PspS19_11160	COG0251	oxidation-reduction process
PspS19_11185	COG3284	Transcriptional regulator
PspS19_11190	COG3199	ATP-NAD kinase
PspS19_11195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PspS19_11200	COG0022	dehydrogenase e1 component
PspS19_11210	COG1063	alcohol dehydrogenase
PspS19_11220	COG3135	benzoate transporter
PspS19_11240	COG0316	Belongs to the HesB IscA family
PspS19_11240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PspS19_11290	COG3706	GGDEF domain
PspS19_11295	COG0251	oxidation-reduction process
PspS19_11310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspS19_11320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspS19_11325	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_11330	COG2610	gluconate transmembrane transporter activity
PspS19_11335	COG2204	response regulator
PspS19_11340	COG4172	Belongs to the ABC transporter superfamily
PspS19_11345	COG4239	(ABC) transporter, permease
PspS19_11350	COG4174	ABC transporter (Permease)
PspS19_11355	COG4166	transmembrane transport
PspS19_11360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspS19_11365	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PspS19_11370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PspS19_11375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspS19_11385	COG2197	response regulator
PspS19_11390	COG0322	excinuclease ABC activity
PspS19_11440	COG0402	S-adenosylhomocysteine deaminase activity
PspS19_11465	COG0129	dihydroxy-acid dehydratase activity
PspS19_11475	COG0583	DNA-binding transcription factor activity
PspS19_11480	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_11485	COG2271	Major facilitator Superfamily
PspS19_11490	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_11495	COG0179	Fumarylacetoacetate (FAA) hydrolase
PspS19_11525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspS19_11540	COG4175	Glycine betaine
PspS19_11555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspS19_11570	COG2146	nitrite reductase [NAD(P)H] activity
PspS19_11570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PspS19_11625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspS19_11630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspS19_11645	COG4771	TonB-dependent receptor
PspS19_11660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_11665	COG1132	(ABC) transporter
PspS19_11670	COG1132	(ABC) transporter
PspS19_11690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_11695	COG0747	negative chemotaxis
PspS19_11700	COG0601	transmembrane transport
PspS19_11705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PspS19_11765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_11775	COG0747	negative chemotaxis
PspS19_11780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_11800	COG3829	transcription factor binding
PspS19_11810	COG0411	ABC transporter
PspS19_11825	COG0559	Belongs to the binding-protein-dependent transport system permease family
PspS19_11850	COG1309	transcriptional regulator
PspS19_11855	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspS19_11860	COG0183	Belongs to the thiolase family
PspS19_11870	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PspS19_11875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_11885	COG0174	glutamine synthetase
PspS19_12110	COG3179	chitinase
PspS19_12175	COG0583	DNA-binding transcription factor activity
PspS19_12185	COG4166	transmembrane transport
PspS19_12190	COG0601	transmembrane transport
PspS19_12200	COG4172	Belongs to the ABC transporter superfamily
PspS19_12235	COG0789	Transcriptional regulator
PspS19_12240	COG1090	epimerase
PspS19_12250	COG0625	glutathione transferase activity
PspS19_12255	COG2267	carboxylic ester hydrolase activity
PspS19_12290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspS19_12295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspS19_12310	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PspS19_12330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PspS19_12400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_12420	COG2814	Major facilitator Superfamily
PspS19_12460	COG2010	Cytochrome c
PspS19_12465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PspS19_12465	COG3608	succinylglutamate desuccinylase aspartoacylase
PspS19_12485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PspS19_12510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PspS19_12510	COG2169	Transcriptional regulator
PspS19_12515	COG3145	DNA-N1-methyladenine dioxygenase activity
PspS19_12535	COG2863	cytochrome
PspS19_12540	COG3258	Cytochrome c
PspS19_12575	COG0450	alkyl hydroperoxide reductase
PspS19_12580	COG3634	alkyl hydroperoxide reductase activity
PspS19_12605	COG2200	EAL domain
PspS19_12610	COG0583	DNA-binding transcription factor activity
PspS19_12615	COG0697	spore germination
PspS19_12630	COG0667	Aldo Keto reductase
PspS19_12635	COG2271	Major facilitator Superfamily
PspS19_12640	COG3835	regulator
PspS19_12645	COG1929	Belongs to the glycerate kinase type-1 family
PspS19_12670	COG3188	usher protein
PspS19_12675	COG3121	Chaperone
PspS19_12685	COG3039	Transposase
PspS19_12690	COG2197	response regulator
PspS19_12710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PspS19_12720	COG1609	Transcriptional regulator
PspS19_12735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PspS19_12740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_12745	COG0745	RESPONSE REGULATOR receiver
PspS19_12750	COG2205	protein histidine kinase activity
PspS19_12780	COG5002	protein histidine kinase activity
PspS19_12795	COG1024	Enoyl-CoA hydratase
PspS19_12800	COG2816	NAD+ diphosphatase activity
PspS19_12830	COG0745	RESPONSE REGULATOR receiver
PspS19_12850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspS19_12865	COG0488	(ABC) transporter
PspS19_12885	COG0477	Major facilitator Superfamily
PspS19_12900	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_12905	COG0010	Belongs to the arginase family
PspS19_12910	COG0154	amidase activity
PspS19_12920	COG2957	Belongs to the agmatine deiminase family
PspS19_12925	COG0583	DNA-binding transcription factor activity
PspS19_12935	COG1595	DNA-templated transcription, initiation
PspS19_12940	COG3712	iron ion homeostasis
PspS19_12965	COG1566	PFAM secretion protein HlyD family protein
PspS19_12975	COG0628	permease
PspS19_12995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PspS19_13005	COG2133	pyrroloquinoline quinone binding
PspS19_13010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PspS19_13015	COG4574	serine-type endopeptidase inhibitor activity
PspS19_13050	COG2198	Histidine kinase
PspS19_13050	COG0784	Response regulator, receiver
PspS19_13050	COG2205	protein histidine kinase activity
PspS19_13055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PspS19_13065	COG5002	protein histidine kinase activity
PspS19_13065	COG2205	protein histidine kinase activity
PspS19_13065	COG0784	Response regulator, receiver
PspS19_13080	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PspS19_13090	COG3781	membrane
PspS19_13115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_13150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PspS19_13195	COG4774	siderophore transport
PspS19_13210	COG4221	oxidoreductase activity
PspS19_13215	COG1902	pentaerythritol trinitrate reductase activity
PspS19_13230	COG2963	transposase activity
PspS19_13255	COG0667	Aldo Keto reductase
PspS19_13260	COG0477	Major facilitator Superfamily
PspS19_13325	COG0410	ABC transporter
PspS19_13335	COG0508	dehydrogenase complex catalyzes the overall conversion of
PspS19_13340	COG1522	sequence-specific DNA binding
PspS19_13355	COG0604	alcohol dehydrogenase
PspS19_13355	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_13355	COG3321	synthase
PspS19_13365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_13390	COG1131	(ABC) transporter
PspS19_13405	COG4585	Histidine kinase
PspS19_13425	COG4993	Dehydrogenase
PspS19_13425	COG2010	Cytochrome c
PspS19_13450	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_13465	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PspS19_13475	COG0535	radical SAM domain protein
PspS19_13490	COG1309	transcriptional regulator
PspS19_13500	COG0493	'glutamate synthase
PspS19_13510	COG1953	Uracil, thiamine, allantoin
PspS19_13525	COG4172	Belongs to the ABC transporter superfamily
PspS19_13530	COG4239	(ABC) transporter, permease
PspS19_13535	COG4174	ABC transporter (Permease)
PspS19_13540	COG4166	transmembrane transport
PspS19_13545	COG4166	transmembrane transport
PspS19_13550	COG0741	lytic transglycosylase activity
PspS19_13550	COG1388	LysM domain
PspS19_13555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PspS19_13565	COG0328	RNA-DNA hybrid ribonuclease activity
PspS19_13575	COG4948	Mandelate Racemase Muconate Lactonizing
PspS19_13580	COG4829	muconolactone delta-isomerase
PspS19_13585	COG3485	protocatechuate 3,4-dioxygenase
PspS19_13615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspS19_13620	COG1982	Orn Lys Arg decarboxylase major
PspS19_13640	COG0431	NADPH-dependent FMN reductase
PspS19_13645	COG0640	Transcriptional regulator
PspS19_13660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PspS19_13665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PspS19_13670	COG0705	Rhomboid family
PspS19_13675	COG3139	Protein of unknown function (DUF1315)
PspS19_13685	COG0308	aminopeptidase N
PspS19_13735	COG0420	3'-5' exonuclease activity
PspS19_13765	COG0714	Associated with various cellular activities
PspS19_13775	COG0579	oxidoreductase
PspS19_13780	COG2186	Transcriptional regulator
PspS19_13805	COG1247	-acetyltransferase
PspS19_13810	COG1794	racemase activity, acting on amino acids and derivatives
PspS19_13825	COG3278	Belongs to the heme-copper respiratory oxidase family
PspS19_13835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PspS19_13845	COG0484	heat shock protein binding
PspS19_13860	COG3119	arylsulfatase activity
PspS19_13875	COG2304	oxidoreductase activity
PspS19_13895	COG0714	Associated with various cellular activities
PspS19_13935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PspS19_13940	COG1538	Outer membrane efflux protein
PspS19_13965	COG0210	DNA helicase
PspS19_13980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_14020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_14030	COG0174	glutamine synthetase
PspS19_14045	COG0446	pyridine nucleotide-disulphide oxidoreductase
PspS19_14045	COG1902	pentaerythritol trinitrate reductase activity
PspS19_14055	COG0235	Class ii aldolase
PspS19_14080	COG0833	amino acid
PspS19_14090	COG1024	Enoyl-CoA hydratase
PspS19_14095	COG1960	acyl-CoA dehydrogenase activity
PspS19_14100	COG0045	succinate-CoA ligase (ADP-forming) activity
PspS19_14120	COG0747	negative chemotaxis
PspS19_14125	COG0601	transmembrane transport
PspS19_14140	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspS19_14145	COG0589	response to stress
PspS19_14190	COG0583	DNA-binding transcription factor activity
PspS19_14220	COG0583	DNA-binding transcription factor activity
PspS19_14230	COG2271	Major facilitator Superfamily
PspS19_14235	COG1082	Xylose isomerase domain protein TIM barrel
PspS19_14250	COG2175	clavaminate synthase activity
PspS19_14255	COG3246	L-lysine catabolic process to acetate
PspS19_14260	COG0477	Major facilitator Superfamily
PspS19_14275	COG2855	membrane
PspS19_14315	COG4447	cellulose binding
PspS19_14325	COG1960	acyl-CoA dehydrogenase activity
PspS19_14330	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_14335	COG1196	nuclear chromosome segregation
PspS19_14335	COG3264	Mechanosensitive ion channel
PspS19_14355	COG1960	acyl-CoA dehydrogenase activity
PspS19_14360	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
PspS19_14395	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_14400	COG1960	acyl-CoA dehydrogenase activity
PspS19_14405	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_14415	COG2030	dehydratase
PspS19_14425	COG1960	acyl-CoA dehydrogenase activity
PspS19_14460	COG2909	trisaccharide binding
PspS19_14480	COG3119	arylsulfatase activity
PspS19_14485	COG1960	acyl-CoA dehydrogenase activity
PspS19_14490	COG1960	acyl-CoA dehydrogenase activity
PspS19_14500	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_14515	COG1024	Enoyl-CoA hydratase
PspS19_14520	COG1960	acyl-CoA dehydrogenase activity
PspS19_14535	COG1024	Enoyl-CoA hydratase
PspS19_14540	COG2186	Transcriptional regulator
PspS19_14560	COG1129	ABC transporter
PspS19_14565	COG1172	Belongs to the binding-protein-dependent transport system permease family
PspS19_14570	COG1879	ABC-type sugar transport system periplasmic component
PspS19_14580	COG2084	Dehydrogenase
PspS19_14585	COG1082	Xylose isomerase domain protein TIM barrel
PspS19_14590	COG0149	triose-phosphate isomerase activity
PspS19_14595	COG0698	ribose 5-phosphate isomerase
PspS19_14600	COG2376	Dihydroxyacetone kinase
PspS19_14610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PspS19_14625	COG3501	Rhs element vgr protein
PspS19_14690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PspS19_14695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PspS19_14700	COG1120	ATPase activity
PspS19_14755	COG2072	flavoprotein involved in K transport
PspS19_14770	COG1960	acyl-CoA dehydrogenase activity
PspS19_14775	COG1960	acyl-CoA dehydrogenase activity
PspS19_14785	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_14805	COG0183	Belongs to the thiolase family
PspS19_14810	COG1960	acyl-CoA dehydrogenase activity
PspS19_14815	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_14825	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_14830	COG1024	Enoyl-CoA hydratase
PspS19_14835	COG2197	response regulator
PspS19_14850	COG1960	acyl-CoA dehydrogenase activity
PspS19_14860	COG2030	dehydratase
PspS19_14870	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_14895	COG2801	Transposase and inactivated derivatives
PspS19_14955	COG5507	3-demethylubiquinone-9 3-methyltransferase
PspS19_14965	COG4974	Belongs to the 'phage' integrase family
PspS19_14970	COG0463	Glycosyl transferase, family 2
PspS19_14975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspS19_14975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PspS19_14980	COG0726	polysaccharide deacetylase
PspS19_14985	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PspS19_14990	COG2076	Multidrug Resistance protein
PspS19_14995	COG2076	Multidrug Resistance protein
PspS19_15015	COG1522	sequence-specific DNA binding
PspS19_15020	COG1024	Enoyl-CoA hydratase
PspS19_15025	COG1960	acyl-CoA dehydrogenase activity
PspS19_15030	COG1024	Enoyl-CoA hydratase
PspS19_15035	COG1960	acyl-CoA dehydrogenase activity
PspS19_15040	COG0183	Belongs to the thiolase family
PspS19_15050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspS19_15065	COG2207	Transcriptional regulator
PspS19_15115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PspS19_15135	COG1968	undecaprenyl-diphosphatase activity
PspS19_15140	COG0840	transmembrane signaling receptor activity
PspS19_15185	COG2204	response regulator
PspS19_15200	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PspS19_15205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PspS19_15210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PspS19_15225	COG2194	sulfuric ester hydrolase activity
PspS19_15235	COG0456	acetyltransferase
PspS19_15240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PspS19_15245	COG2233	PERMEase
PspS19_15310	COG1238	metal cluster binding
PspS19_15315	COG0297	glycogen (starch) synthase activity
PspS19_15320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PspS19_15325	COG1640	4-alpha-glucanotransferase
PspS19_15350	COG3568	Endonuclease Exonuclease Phosphatase
PspS19_15370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PspS19_15390	COG1137	ATPase activity
PspS19_15395	COG1285	pathogenesis
PspS19_15405	COG0348	domain, Protein
PspS19_15410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_15415	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_15420	COG2205	protein histidine kinase activity
PspS19_15420	COG0784	Response regulator, receiver
PspS19_15450	COG1522	sequence-specific DNA binding
PspS19_15455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PspS19_15460	COG0022	dehydrogenase e1 component
PspS19_15470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspS19_15475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PspS19_15480	COG0583	DNA-binding transcription factor activity
PspS19_15495	COG2124	cytochrome p450
PspS19_15510	COG4335	DNA alkylation repair
PspS19_15535	COG3712	iron ion homeostasis
PspS19_15560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PspS19_15585	COG1595	DNA-templated transcription, initiation
PspS19_15590	COG3712	iron ion homeostasis
PspS19_15630	COG4774	siderophore transport
PspS19_15640	COG3712	iron ion homeostasis
PspS19_15645	COG1595	DNA-templated transcription, initiation
PspS19_15665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_15670	COG1473	amidohydrolase
PspS19_15690	COG0789	Transcriptional regulator
PspS19_15705	COG1595	DNA-templated transcription, initiation
PspS19_15710	COG3712	iron ion homeostasis
PspS19_15715	COG4774	siderophore transport
PspS19_15725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_15735	COG1522	sequence-specific DNA binding
PspS19_15760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PspS19_15775	COG0789	Transcriptional regulator
PspS19_15805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PspS19_15810	COG0583	DNA-binding transcription factor activity
PspS19_15815	COG3048	D-serine ammonia-lyase activity
PspS19_15820	COG2610	gluconate transmembrane transporter activity
PspS19_15830	COG0583	DNA-binding transcription factor activity
PspS19_15835	COG0477	Major facilitator Superfamily
PspS19_15840	COG0235	Class ii aldolase
PspS19_15845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspS19_15865	COG0668	transmembrane transport
PspS19_15885	COG1538	Outer membrane efflux protein
PspS19_15925	COG0778	Nitroreductase
PspS19_15935	COG0179	Fumarylacetoacetate (FAA) hydrolase
PspS19_15950	COG1566	PFAM secretion protein HlyD family protein
PspS19_15960	COG1289	transmembrane transporter activity
PspS19_15970	COG1335	isochorismatase
PspS19_15975	COG1335	isochorismatase
PspS19_15985	COG0583	DNA-binding transcription factor activity
PspS19_16000	COG1120	ATPase activity
PspS19_16010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PspS19_16025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_16030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PspS19_16035	COG2814	Major facilitator Superfamily
PspS19_16045	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_16050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspS19_16055	COG2814	Major facilitator Superfamily
PspS19_16060	COG1309	transcriptional regulator
PspS19_16065	COG0583	DNA-binding transcription factor activity
PspS19_16070	COG2814	Major facilitator Superfamily
PspS19_16095	COG1733	regulation of RNA biosynthetic process
PspS19_16100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspS19_16110	COG0861	Integral membrane protein TerC family
PspS19_16115	COG0589	response to stress
PspS19_16140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PspS19_16145	COG0581	inorganic phosphate transmembrane transporter activity
PspS19_16155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PspS19_16170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PspS19_16185	COG1733	regulation of RNA biosynthetic process
PspS19_16195	COG3474	cytochrome
PspS19_16210	COG1802	Transcriptional regulator
PspS19_16220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PspS19_16220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_16235	COG2207	Transcriptional regulator
PspS19_16235	COG0662	Cupin 2, conserved barrel domain protein
PspS19_16250	COG0765	amino acid transport
PspS19_16255	COG0765	amino acid transport
PspS19_16270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PspS19_16280	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_16290	COG0667	Aldo Keto reductase
PspS19_16300	COG1253	flavin adenine dinucleotide binding
PspS19_16360	COG1522	sequence-specific DNA binding
PspS19_16370	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PspS19_16385	COG0697	spore germination
PspS19_16400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_16410	COG2423	ornithine cyclodeaminase activity
PspS19_16420	COG2207	Transcriptional regulator
PspS19_16425	COG1999	signal sequence binding
PspS19_16435	COG1595	DNA-templated transcription, initiation
PspS19_16500	COG0579	oxidoreductase
PspS19_16525	COG0450	alkyl hydroperoxide reductase
PspS19_16530	COG0534	Mate efflux family protein
PspS19_16540	COG0024	Methionine aminopeptidase
PspS19_16550	COG0154	amidase activity
PspS19_16570	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
PspS19_16580	COG5002	protein histidine kinase activity
PspS19_16580	COG5001	Diguanylate cyclase
PspS19_16580	COG3447	MASE1 domain protein
PspS19_16600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspS19_16605	COG0659	secondary active sulfate transmembrane transporter activity
PspS19_16620	COG3712	iron ion homeostasis
PspS19_16640	COG0494	nUDIX hydrolase
PspS19_16655	COG1595	DNA-templated transcription, initiation
PspS19_16675	COG0596	Alpha beta hydrolase
PspS19_16685	COG1309	transcriptional regulator
PspS19_16700	COG1595	DNA-templated transcription, initiation
PspS19_16720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_16725	COG0583	DNA-binding transcription factor activity
PspS19_16730	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_16745	COG1126	abc transporter atp-binding protein
PspS19_16750	COG0765	amino acid transport
PspS19_16755	COG0765	amino acid transport
PspS19_16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_16770	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_16780	COG1522	sequence-specific DNA binding
PspS19_16790	COG0583	DNA-binding transcription factor activity
PspS19_16795	COG0833	amino acid
PspS19_16800	COG0626	cystathionine gamma-synthase activity
PspS19_16805	COG1132	(ABC) transporter
PspS19_16820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_16850	COG2080	2 iron, 2 sulfur cluster binding
PspS19_16855	COG2207	Transcriptional regulator
PspS19_16860	COG1064	alcohol dehydrogenase
PspS19_16885	COG0494	nUDIX hydrolase
PspS19_16890	COG2207	Transcriptional regulator
PspS19_16895	COG0535	radical SAM domain protein
PspS19_16910	COG3284	Transcriptional regulator
PspS19_16915	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_16955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_17005	COG1960	acyl-CoA dehydrogenase activity
PspS19_17010	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_17035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PspS19_17140	COG4638	Rieske (2fe-2S)
PspS19_17155	COG0019	diaminopimelate decarboxylase activity
PspS19_17175	COG4215	(ABC) transporter
PspS19_17185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_17190	COG1126	abc transporter atp-binding protein
PspS19_17220	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
PspS19_17225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PspS19_17230	COG1902	pentaerythritol trinitrate reductase activity
PspS19_17240	COG2249	NAD(P)H dehydrogenase (quinone) activity
PspS19_17265	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_17295	COG4999	Histidine kinase
PspS19_17295	COG3437	response regulator, receiver
PspS19_17295	COG2205	protein histidine kinase activity
PspS19_17295	COG3850	Histidine kinase
PspS19_17300	COG3437	response regulator, receiver
PspS19_17305	COG3064	Membrane
PspS19_17325	COG0826	peptidase U32
PspS19_17340	COG0174	glutamine synthetase
PspS19_17360	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
PspS19_17375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PspS19_17415	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
PspS19_17420	COG0747	negative chemotaxis
PspS19_17425	COG0601	transmembrane transport
PspS19_17430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PspS19_17435	COG0444	Belongs to the ABC transporter superfamily
PspS19_17440	COG4608	Belongs to the ABC transporter superfamily
PspS19_17455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PspS19_17460	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
PspS19_17465	COG0477	Major facilitator Superfamily
PspS19_17480	COG2205	protein histidine kinase activity
PspS19_17485	COG0745	RESPONSE REGULATOR receiver
PspS19_17525	COG3501	Rhs element vgr protein
PspS19_17575	COG0814	amino acid
PspS19_17580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspS19_17590	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_17610	COG2111	Na H antiporter
PspS19_17610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PspS19_17615	COG1006	Multisubunit Na H antiporter MnhC subunit
PspS19_17620	COG0651	ATP synthesis coupled electron transport
PspS19_17630	COG2212	antiporter activity
PspS19_17635	COG1320	monovalent cation:proton antiporter activity
PspS19_17670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PspS19_17695	COG4206	TonB-dependent receptor
PspS19_17710	COG3706	GGDEF domain
PspS19_17725	COG5383	Protein conserved in bacteria
PspS19_17745	COG4181	ATPase activity
PspS19_17750	COG2015	COG2015, Alkyl sulfatase and related hydrolases
PspS19_17775	COG2207	Transcriptional regulator
PspS19_17785	COG4566	intracellular signal transduction
PspS19_17790	COG4191	Histidine kinase
PspS19_17800	COG1960	acyl-CoA dehydrogenase activity
PspS19_17810	COG1879	ABC-type sugar transport system periplasmic component
PspS19_17830	COG0616	signal peptide processing
PspS19_17865	COG4191	Histidine kinase
PspS19_17865	COG0784	Response regulator, receiver
PspS19_17875	COG0587	DNA-directed DNA polymerase activity
PspS19_17880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PspS19_17890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PspS19_17960	COG1286	toxin biosynthetic process
PspS19_17965	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PspS19_17970	COG0285	dihydrofolate synthase activity
PspS19_17975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PspS19_17980	COG0135	phosphoribosylanthranilate isomerase activity
PspS19_18005	COG0473	3-isopropylmalate dehydrogenase activity
PspS19_18010	COG2226	methyltransferase
PspS19_18015	COG0066	3-isopropylmalate dehydratase activity
PspS19_18020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PspS19_18035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PspS19_18040	COG2267	carboxylic ester hydrolase activity
PspS19_18045	COG2453	phosphatase
PspS19_18045	COG0671	phosphoesterase, PA-phosphatase related
PspS19_18060	COG4589	Belongs to the CDS family
PspS19_18070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PspS19_18075	COG3340	Belongs to the peptidase S51 family
PspS19_18090	COG0395	ABC-type sugar transport system, permease component
PspS19_18100	COG3842	ATPase activity
PspS19_18105	COG3842	ATPase activity
PspS19_18110	COG3284	Transcriptional regulator
PspS19_18115	COG0786	glutamate:sodium symporter activity
PspS19_18120	COG0010	Belongs to the arginase family
PspS19_18130	COG0215	cysteine-tRNA ligase activity
PspS19_18135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PspS19_18145	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PspS19_18180	COG2168	tRNA wobble position uridine thiolation
PspS19_18190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PspS19_18195	COG0435	Glutathione S-transferase
PspS19_18215	COG1648	precorrin-2 dehydrogenase activity
PspS19_18215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PspS19_18220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PspS19_18225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PspS19_18230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PspS19_18235	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PspS19_18240	COG1674	ftsk spoiiie
PspS19_18245	COG0492	ferredoxin-NADP+ reductase activity
PspS19_18250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PspS19_18255	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PspS19_18260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PspS19_18270	COG0542	response to heat
PspS19_18275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PspS19_18280	COG1278	Cold shock
PspS19_18310	COG0482	sulfurtransferase activity
PspS19_18315	COG2915	High frequency lysogenization protein hflD homolog
PspS19_18325	COG2850	peptidyl-arginine hydroxylation
PspS19_18330	COG2153	protein acetylation
PspS19_18345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspS19_18350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspS19_18355	COG0649	NAD binding
PspS19_18355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspS19_18370	COG1034	ATP synthesis coupled electron transport
PspS19_18375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PspS19_18380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PspS19_18390	COG0713	ATP synthesis coupled electron transport
PspS19_18415	COG0596	Alpha beta hydrolase
PspS19_18445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PspS19_18460	COG0556	nucleotide-excision repair
PspS19_18485	COG2233	PERMEase
PspS19_18500	COG2203	Gaf domain
PspS19_18500	COG5001	Diguanylate cyclase
PspS19_18500	COG3706	GGDEF domain
PspS19_18500	COG4251	negative regulation of phosphorylation
PspS19_18520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PspS19_18525	COG0431	NADPH-dependent FMN reductase
PspS19_18535	COG3436	PFAM IS66 Orf2 family protein
PspS19_18540	COG4372	Transposase
PspS19_18555	COG3436	PFAM IS66 Orf2 family protein
PspS19_18560	COG4372	Transposase
PspS19_18580	COG1596	polysaccharide export
PspS19_18590	COG3562	capsule polysaccharide
PspS19_18605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PspS19_18615	COG0517	IMP dehydrogenase activity
PspS19_18615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PspS19_18635	COG0300	oxidoreductase activity
PspS19_18665	COG0156	8-amino-7-oxononanoate synthase activity
PspS19_18680	COG1733	regulation of RNA biosynthetic process
PspS19_18685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PspS19_18715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PspS19_18720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PspS19_18730	COG2204	response regulator
PspS19_18750	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PspS19_18750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PspS19_18770	COG4591	ABC-type transport system involved in lipoprotein release permease component
PspS19_18775	COG1136	(ABC) transporter
PspS19_18780	COG4591	ABC-type transport system involved in lipoprotein release permease component
PspS19_18790	COG0584	glycerophosphoryl diester phosphodiesterase
PspS19_18795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PspS19_18800	COG1477	protein flavinylation
PspS19_18815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PspS19_18825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PspS19_18870	COG0183	Belongs to the thiolase family
PspS19_18875	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspS19_18875	COG1024	Enoyl-CoA hydratase
PspS19_18885	COG0589	response to stress
PspS19_18895	COG0741	lytic transglycosylase activity
PspS19_18905	COG1132	(ABC) transporter
PspS19_18915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspS19_18925	COG0425	Belongs to the sulfur carrier protein TusA family
PspS19_18930	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PspS19_18940	COG0840	transmembrane signaling receptor activity
PspS19_18950	COG3278	Belongs to the heme-copper respiratory oxidase family
PspS19_18965	COG2010	Cytochrome c
PspS19_18970	COG3278	Belongs to the heme-copper respiratory oxidase family
PspS19_18985	COG2010	Cytochrome c
PspS19_18990	COG0348	domain, Protein
PspS19_19020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PspS19_19025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PspS19_19030	COG1960	acyl-CoA dehydrogenase activity
PspS19_19035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PspS19_19040	COG2130	NADP-dependent
PspS19_19045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PspS19_19050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PspS19_19080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PspS19_19085	COG3115	cell septum assembly
PspS19_19105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PspS19_19115	COG0402	S-adenosylhomocysteine deaminase activity
PspS19_19120	COG1802	Transcriptional regulator
PspS19_19125	COG3135	benzoate transporter
PspS19_19130	COG0455	bacterial-type flagellum organization
PspS19_19175	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PspS19_19195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PspS19_19200	COG3171	Protein conserved in bacteria
PspS19_19210	COG0745	RESPONSE REGULATOR receiver
PspS19_19210	COG3706	GGDEF domain
PspS19_19215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspS19_19215	COG0116	Belongs to the methyltransferase superfamily
PspS19_19225	COG3130	regulation of translation
PspS19_19230	COG0167	dihydroorotate dehydrogenase activity
PspS19_19235	COG1116	anion transmembrane transporter activity
PspS19_19235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspS19_19240	COG3707	response regulator
PspS19_19250	COG2223	nitrite transmembrane transporter activity
PspS19_19255	COG0515	serine threonine protein kinase
PspS19_19255	COG2815	serine threonine protein kinase
PspS19_19265	COG0243	molybdopterin cofactor binding
PspS19_19270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PspS19_19275	COG3047	cAMP biosynthetic process
PspS19_19275	COG2885	chlorophyll binding
PspS19_19285	COG0668	transmembrane transport
PspS19_19300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PspS19_19315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PspS19_19320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_19340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PspS19_19345	COG0372	Belongs to the citrate synthase family
PspS19_19355	COG1802	Transcriptional regulator
PspS19_19360	COG0189	ligase activity
PspS19_19360	COG4067	protein conserved in archaea
PspS19_19370	COG0189	ligase activity
PspS19_19380	COG0560	Phosphoserine phosphatase
PspS19_19395	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_19400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PspS19_19430	COG0393	Putative heavy-metal-binding
PspS19_19445	COG1454	alcohol dehydrogenase
PspS19_19450	COG1454	alcohol dehydrogenase
PspS19_19455	COG0410	ABC transporter
PspS19_19460	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PspS19_19480	COG0683	leucine binding
PspS19_19490	COG3852	Histidine kinase
PspS19_19495	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_19505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PspS19_19545	COG0183	Belongs to the thiolase family
PspS19_19550	COG0583	DNA-binding transcription factor activity
PspS19_19555	COG3284	Transcriptional regulator
PspS19_19560	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_19575	COG0204	Acyl-transferase
PspS19_19580	COG0598	Magnesium transport protein CorA
PspS19_19590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_19595	COG0577	efflux transmembrane transporter activity
PspS19_19595	COG1136	(ABC) transporter
PspS19_19605	COG4774	siderophore transport
PspS19_19615	COG1309	transcriptional regulator
PspS19_19620	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
PspS19_19630	COG3387	PFAM Glycoside hydrolase 15-related
PspS19_19635	COG4977	sequence-specific DNA binding
PspS19_19685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PspS19_19700	COG1404	Belongs to the peptidase S8 family
PspS19_19705	COG1132	(ABC) transporter
PspS19_19710	COG3284	Transcriptional regulator
PspS19_19715	COG0768	penicillin binding
PspS19_19740	COG5006	permease, DMT superfamily
PspS19_19750	COG1309	transcriptional regulator
PspS19_19755	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_19825	COG1121	(ABC) transporter
PspS19_19830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PspS19_19840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PspS19_19845	COG0642	Histidine kinase
PspS19_19850	COG0745	RESPONSE REGULATOR receiver
PspS19_19860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PspS19_19885	COG1309	transcriptional regulator
PspS19_19895	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_19900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PspS19_19905	COG1960	acyl-CoA dehydrogenase activity
PspS19_19925	COG3123	guanosine phosphorylase activity
PspS19_19930	COG3217	Mosc domain protein beta barrel domain protein
PspS19_19930	COG0633	Ferredoxin
PspS19_19945	COG3851	Histidine kinase
PspS19_19950	COG2197	response regulator
PspS19_19955	COG1597	lipid kinase activity
PspS19_19970	COG0521	Mo-molybdopterin cofactor biosynthetic process
PspS19_19975	COG0746	molybdenum cofactor guanylyltransferase activity
PspS19_19985	COG0564	pseudouridine synthase activity
PspS19_20005	COG0004	ammonium transporteR
PspS19_20035	COG2197	response regulator
PspS19_20040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_20040	COG2205	protein histidine kinase activity
PspS19_20045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PspS19_20050	COG1956	GAF domain-containing protein
PspS19_20060	COG5002	protein histidine kinase activity
PspS19_20060	COG2205	protein histidine kinase activity
PspS19_20060	COG0784	Response regulator, receiver
PspS19_20065	COG1846	Transcriptional regulator
PspS19_20070	COG0386	Belongs to the glutathione peroxidase family
PspS19_20075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspS19_20080	COG0436	Aminotransferase
PspS19_20085	COG0501	Belongs to the peptidase M48B family
PspS19_20090	COG0500	methyltransferase
PspS19_20095	COG3384	dioxygenase
PspS19_20105	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspS19_20105	COG1024	Enoyl-CoA hydratase
PspS19_20115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PspS19_20120	COG3214	Protein conserved in bacteria
PspS19_20135	COG0583	DNA-binding transcription factor activity
PspS19_20145	COG0583	DNA-binding transcription factor activity
PspS19_20150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PspS19_20165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspS19_20175	COG0589	response to stress
PspS19_20185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PspS19_20200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PspS19_20215	COG1376	ErfK ybiS ycfS ynhG family protein
PspS19_20230	COG4181	ATPase activity
PspS19_20235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PspS19_20250	COG2259	Doxx family
PspS19_20255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PspS19_20260	COG0084	hydrolase, TatD family'
PspS19_20295	COG0745	RESPONSE REGULATOR receiver
PspS19_20300	COG2205	protein histidine kinase activity
PspS19_20305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PspS19_20315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PspS19_20355	COG1555	photosystem II stabilization
PspS19_20385	COG0438	transferase activity, transferring glycosyl groups
PspS19_20405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PspS19_20420	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PspS19_20440	COG0776	regulation of translation
PspS19_20455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PspS19_20460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PspS19_20465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PspS19_20475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PspS19_20485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PspS19_20490	COG0402	S-adenosylhomocysteine deaminase activity
PspS19_20495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PspS19_20500	COG0546	phosphoglycolate phosphatase activity
PspS19_20505	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_20510	COG3706	GGDEF domain
PspS19_20520	COG5001	Diguanylate cyclase
PspS19_20520	COG5002	protein histidine kinase activity
PspS19_20540	COG0271	Belongs to the BolA IbaG family
PspS19_20550	COG0114	fumarate hydratase activity
PspS19_20555	COG0697	spore germination
PspS19_20560	COG0183	Belongs to the thiolase family
PspS19_20565	COG2326	polyphosphate kinase activity
PspS19_20570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PspS19_20570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_20610	COG0367	asparagine synthase
PspS19_20625	COG3089	Belongs to the UPF0270 family
PspS19_20630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PspS19_20635	COG1742	UPF0060 membrane protein
PspS19_20650	COG1368	sulfuric ester hydrolase activity
PspS19_20670	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_20680	COG2197	response regulator
PspS19_20685	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PspS19_20695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PspS19_20700	COG1073	alpha beta
PspS19_20725	COG2840	Smr protein MutS2
PspS19_20730	COG0302	gtp cyclohydrolase
PspS19_20740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_20750	COG2252	PERMEase
PspS19_20775	COG4266	Belongs to the allantoicase family
PspS19_20780	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
PspS19_20790	COG2233	PERMEase
PspS19_20810	COG1560	Kdo2-lipid A biosynthetic process
PspS19_20815	COG0850	regulation of cytokinetic process
PspS19_20820	COG2894	cell division
PspS19_20825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PspS19_20830	COG0564	pseudouridine synthase activity
PspS19_20840	COG1362	aminopeptidase activity
PspS19_20845	COG0668	transmembrane transport
PspS19_20885	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_20935	COG0545	Peptidyl-prolyl cis-trans isomerase
PspS19_20940	COG2010	Cytochrome c
PspS19_20975	COG2974	May be involved in recombination
PspS19_20980	COG0385	Bile acid
PspS19_20985	COG2076	Multidrug Resistance protein
PspS19_21005	COG2205	protein histidine kinase activity
PspS19_21055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PspS19_21060	COG0406	alpha-ribazole phosphatase activity
PspS19_21065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PspS19_21075	COG1492	cobalamin metabolic process
PspS19_21090	COG0778	Nitroreductase
PspS19_21095	COG1797	cobyrinic acid a,c-diamide synthase activity
PspS19_21115	COG0791	NLP P60 protein
PspS19_21120	COG0791	NLP P60 protein
PspS19_21125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PspS19_21130	COG0628	permease
PspS19_21140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PspS19_21145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PspS19_21165	COG3122	Protein conserved in bacteria
PspS19_21170	COG3956	TIGRFAM MazG family protein
PspS19_21175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PspS19_21180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PspS19_21200	COG2205	protein histidine kinase activity
PspS19_21200	COG0784	Response regulator, receiver
PspS19_21200	COG5002	protein histidine kinase activity
PspS19_21205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspS19_21220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PspS19_21225	COG1393	Belongs to the ArsC family
PspS19_21260	COG2818	Glycosylase
PspS19_21265	COG0037	tRNA processing
PspS19_21275	COG3091	SprT-like family
PspS19_21280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PspS19_21300	COG0745	RESPONSE REGULATOR receiver
PspS19_21315	COG2205	protein histidine kinase activity
PspS19_21320	COG0745	RESPONSE REGULATOR receiver
PspS19_21330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PspS19_21360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PspS19_21375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PspS19_21400	COG3706	GGDEF domain
PspS19_21415	COG0504	CTP synthase activity
PspS19_21420	COG2329	Antibiotic biosynthesis monooxygenase
PspS19_21430	COG0584	glycerophosphoryl diester phosphodiesterase
PspS19_21470	COG1984	allophanate hydrolase subunit 2
PspS19_21480	COG0439	Biotin carboxylase
PspS19_21490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PspS19_21505	COG0583	DNA-binding transcription factor activity
PspS19_21510	COG4941	Belongs to the sigma-70 factor family
PspS19_21520	COG3795	YCII-related domain
PspS19_21535	COG1247	-acetyltransferase
PspS19_21550	COG0436	Aminotransferase
PspS19_21560	COG3265	gluconokinase activity
PspS19_21565	COG1609	Transcriptional regulator
PspS19_21570	COG0583	DNA-binding transcription factor activity
PspS19_21590	COG0242	peptide deformylase activity
PspS19_21595	COG1295	ribonuclease BN
PspS19_21610	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_21615	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_21620	COG2267	carboxylic ester hydrolase activity
PspS19_21625	COG2030	dehydratase
PspS19_21635	COG3530	Putative quorum-sensing-regulated virulence factor
PspS19_21640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PspS19_21645	COG0800	Aldolase
PspS19_21660	COG1737	Transcriptional regulator
PspS19_21665	COG0676	glucose-6-phosphate 1-epimerase activity
PspS19_21675	COG3842	ATPase activity
PspS19_21680	COG0395	ABC-type sugar transport system, permease component
PspS19_21690	COG1653	transport
PspS19_21700	COG2205	protein histidine kinase activity
PspS19_21705	COG0745	RESPONSE REGULATOR receiver
PspS19_21725	COG1803	Methylglyoxal synthase
PspS19_21730	COG1595	DNA-templated transcription, initiation
PspS19_21735	COG3712	iron ion homeostasis
PspS19_21740	COG4771	TonB-dependent receptor
PspS19_21750	COG2832	Protein of unknown function (DUF454)
PspS19_21755	COG0840	transmembrane signaling receptor activity
PspS19_21785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PspS19_21830	COG0509	glycine decarboxylation via glycine cleavage system
PspS19_21835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspS19_21835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspS19_21840	COG1760	l-serine dehydratase
PspS19_21845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PspS19_21850	COG1278	Cold shock
PspS19_21860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PspS19_21870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PspS19_21875	COG0602	queuosine metabolic process
PspS19_21880	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PspS19_21885	COG2885	chlorophyll binding
PspS19_21890	COG0823	Involved in the tonB-independent uptake of proteins
PspS19_21910	COG0824	Thioesterase
PspS19_21915	COG2255	four-way junction helicase activity
PspS19_21920	COG0632	four-way junction helicase activity
PspS19_21925	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PspS19_21930	COG0217	transcriptional regulatory protein
PspS19_21935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PspS19_21950	COG0783	Belongs to the Dps family
PspS19_21960	COG2900	Belongs to the SlyX family
PspS19_21975	COG0668	transmembrane transport
PspS19_21980	COG1666	GTP binding
PspS19_21990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_21990	COG4191	Histidine kinase
PspS19_21995	COG2096	Adenosyltransferase
PspS19_22000	COG0494	nUDIX hydrolase
PspS19_22010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PspS19_22015	COG0653	protein targeting
PspS19_22025	COG0433	COG0433 Predicted ATPase
PspS19_22045	COG2925	Exonuclease
PspS19_22070	COG0714	Associated with various cellular activities
PspS19_22090	COG0469	pyruvate kinase activity
PspS19_22110	COG2801	Transposase and inactivated derivatives
PspS19_22115	COG1024	Enoyl-CoA hydratase
PspS19_22125	COG3706	GGDEF domain
PspS19_22135	COG4191	Histidine kinase
PspS19_22145	COG0477	Major facilitator Superfamily
PspS19_22170	COG2207	Transcriptional regulator
PspS19_22175	COG3842	ATPase activity
PspS19_22185	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_22205	COG0583	DNA-binding transcription factor activity
PspS19_22220	COG2910	NAD(P)H-binding
PspS19_22230	COG0583	DNA-binding transcription factor activity
PspS19_22260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PspS19_22265	COG0583	DNA-binding transcription factor activity
PspS19_22280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PspS19_22310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_22315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PspS19_22325	COG3642	lipopolysaccharide core region biosynthetic process
PspS19_22335	COG0642	Histidine kinase
PspS19_22350	COG0459	protein refolding
PspS19_22355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PspS19_22370	COG1028	Short-chain dehydrogenase reductase Sdr
PspS19_22375	COG0489	protein tyrosine kinase activity
PspS19_22380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PspS19_22380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PspS19_22385	COG4657	Part of a membrane complex involved in electron transport
PspS19_22390	COG2878	Part of a membrane complex involved in electron transport
PspS19_22395	COG4658	electron transport chain
PspS19_22400	COG4659	FMN binding
PspS19_22410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PspS19_22420	COG2197	response regulator
PspS19_22430	COG0137	argininosuccinate synthase activity
PspS19_22440	COG0418	dihydroorotase activity
PspS19_22445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspS19_22450	COG0450	alkyl hydroperoxide reductase
PspS19_22455	COG2906	2 iron, 2 sulfur cluster binding
PspS19_22465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PspS19_22470	COG0243	molybdopterin cofactor binding
PspS19_22475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PspS19_22480	COG3842	ATPase activity
PspS19_22490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PspS19_22500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PspS19_22520	COG0765	amino acid transport
PspS19_22525	COG0765	amino acid transport
PspS19_22530	COG1126	abc transporter atp-binding protein
PspS19_22555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PspS19_22560	COG0583	DNA-binding transcription factor activity
PspS19_22565	COG1280	lysine exporter protein (LysE YggA)
PspS19_22570	COG0494	nUDIX hydrolase
PspS19_22575	COG2197	response regulator
PspS19_22580	COG0069	glutamate synthase activity
PspS19_22590	COG1113	amino acid transport
PspS19_22630	COG1695	Transcriptional regulator
PspS19_22635	COG2375	cellular response to nickel ion
PspS19_22650	COG4628	conserved protein (DUF2132)
PspS19_22665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PspS19_22680	COG2226	methyltransferase
PspS19_22685	COG0500	methyltransferase
PspS19_22690	COG0590	tRNA wobble adenosine to inosine editing
PspS19_22700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PspS19_22700	COG0519	Catalyzes the synthesis of GMP from XMP
PspS19_22725	COG1570	exodeoxyribonuclease VII activity
PspS19_22730	COG0739	heme binding
PspS19_22740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PspS19_22750	COG0436	Aminotransferase
PspS19_22755	COG1160	GTP binding
PspS19_22770	COG0124	histidyl-tRNA synthetase
PspS19_22775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PspS19_22780	COG1426	Protein conserved in bacteria
PspS19_22790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PspS19_22795	COG0105	UTP biosynthetic process
PspS19_22800	COG2975	iron-sulfur cluster assembly
PspS19_22805	COG0633	Ferredoxin
PspS19_22810	COG0443	Heat shock 70 kDa protein
PspS19_22815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PspS19_22820	COG0316	Belongs to the HesB IscA family
PspS19_22830	COG1104	cysteine desulfurase activity
PspS19_22840	COG1045	serine acetyltransferase
PspS19_22855	COG3134	Outer membrane lipoprotein
PspS19_22870	COG1862	Preprotein translocase
PspS19_22875	COG0343	queuine tRNA-ribosyltransferase activity
PspS19_22880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PspS19_22890	COG4372	Transposase
PspS19_22895	COG3436	PFAM IS66 Orf2 family protein
PspS19_22900	COG0358	DNA primase activity
PspS19_22915	COG1522	sequence-specific DNA binding
PspS19_22975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PspS19_22995	COG0745	RESPONSE REGULATOR receiver
PspS19_23025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PspS19_23030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspS19_23035	COG0583	DNA-binding transcription factor activity
PspS19_23055	COG2801	Transposase and inactivated derivatives
PspS19_23070	COG3706	GGDEF domain
PspS19_23075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspS19_23080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PspS19_23085	COG0745	RESPONSE REGULATOR receiver
PspS19_23095	COG0235	Class ii aldolase
PspS19_23110	COG0583	DNA-binding transcription factor activity
PspS19_23115	COG3842	ATPase activity
PspS19_23125	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_23130	COG1177	transmembrane transport
PspS19_23140	COG2801	Transposase and inactivated derivatives
PspS19_23150	COG0109	protoheme IX farnesyltransferase activity
PspS19_23160	COG1845	cytochrome c oxidase, subunit III
PspS19_23165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PspS19_23170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PspS19_23180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PspS19_23185	COG2801	Transposase and inactivated derivatives
PspS19_23195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PspS19_23195	COG1017	nitric oxide dioxygenase activity
PspS19_23200	COG3604	Transcriptional regulator
PspS19_23245	COG5002	protein histidine kinase activity
PspS19_23260	COG2203	Gaf domain
PspS19_23260	COG5001	Diguanylate cyclase
PspS19_23260	COG4251	negative regulation of phosphorylation
PspS19_23260	COG3706	GGDEF domain
PspS19_23265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PspS19_23270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PspS19_23285	COG1181	Belongs to the D-alanine--D-alanine ligase family
PspS19_23290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PspS19_23295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PspS19_23300	COG0772	Belongs to the SEDS family
PspS19_23305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PspS19_23310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PspS19_23315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PspS19_23320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PspS19_23335	COG0275	rRNA processing
PspS19_23340	COG2001	Belongs to the MraZ family
PspS19_23355	COG3107	peptidoglycan biosynthetic process
PspS19_23360	COG0792	nuclease activity
PspS19_23365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PspS19_23370	COG2823	Periplasmic or secreted lipoprotein
PspS19_23375	COG2969	positive regulation of protein catabolic process
PspS19_23380	COG0625	glutathione transferase activity
PspS19_23385	COG2857	Cytochrome c1
PspS19_23390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PspS19_23395	COG0723	plastoquinol--plastocyanin reductase activity
PspS19_23400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PspS19_23405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PspS19_23410	COG0667	Aldo Keto reductase
PspS19_23415	COG1960	acyl-CoA dehydrogenase activity
PspS19_23440	COG0252	asparaginase activity
PspS19_23445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PspS19_23450	COG0180	Tryptophanyl-tRNA synthetase
PspS19_23470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PspS19_23480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PspS19_23490	COG0583	DNA-binding transcription factor activity
PspS19_23510	COG0318	PFAM AMP-dependent synthetase and ligase
PspS19_23525	COG1280	lysine exporter protein (LysE YggA)
PspS19_23530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PspS19_23535	COG2813	Specifically methylates the guanine in position
PspS19_23540	COG2119	membrane
PspS19_23545	COG0501	Belongs to the peptidase M48B family
PspS19_23550	COG2135	peptidase activity
PspS19_23610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PspS19_23620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PspS19_23625	COG1090	epimerase
PspS19_23630	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
PspS19_23640	COG0789	Transcriptional regulator
PspS19_23645	COG0415	Belongs to the DNA photolyase family
PspS19_23665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PspS19_23670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PspS19_23680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PspS19_23685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PspS19_23695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PspS19_23700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PspS19_23710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PspS19_23715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PspS19_23720	COG0193	aminoacyl-tRNA hydrolase activity
PspS19_23725	COG0012	GTP binding
PspS19_23730	COG2223	nitrite transmembrane transporter activity
PspS19_23740	COG0405	Gamma-glutamyltransferase
PspS19_23750	COG1280	lysine exporter protein (LysE YggA)
PspS19_23760	COG0662	Cupin 2, conserved barrel domain protein
PspS19_23775	COG2801	Transposase and inactivated derivatives
PspS19_23795	COG0477	Major facilitator Superfamily
PspS19_23805	COG0288	reversible hydration of carbon dioxide
PspS19_23815	COG0456	acetyltransferase
PspS19_23840	COG3008	intermembrane lipid transfer
PspS19_23845	COG2995	paraquat-inducible protein a
PspS19_23850	COG2995	paraquat-inducible protein a
PspS19_23875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PspS19_23880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PspS19_23885	COG1183	phosphatidylcholine synthase activity
PspS19_23890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PspS19_23900	COG0028	Belongs to the TPP enzyme family
PspS19_23915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PspS19_23940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PspS19_23945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PspS19_23950	COG4558	Periplasmic binding protein
PspS19_23960	COG1489	DNA binding
PspS19_23965	COG0436	Aminotransferase
PspS19_23970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PspS19_23975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PspS19_23980	COG3852	Histidine kinase
PspS19_24000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PspS19_24005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PspS19_24010	COG0166	Belongs to the GPI family
PspS19_24015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PspS19_24025	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PspS19_24035	COG2823	Periplasmic or secreted lipoprotein
PspS19_24050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PspS19_24055	COG0237	dephospho-CoA kinase activity
PspS19_24060	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PspS19_24085	COG3135	benzoate transporter
PspS19_24090	COG2814	Major facilitator Superfamily
PspS19_24115	COG1252	NADH dehydrogenase
PspS19_24140	COG0542	response to heat
PspS19_24170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_24200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PspS19_24205	COG1047	Peptidyl-prolyl cis-trans
PspS19_24210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PspS19_24215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PspS19_24220	COG0196	riboflavin kinase activity
PspS19_24230	COG0268	Binds directly to 16S ribosomal RNA
PspS19_24235	COG3045	CreA protein
PspS19_24240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PspS19_24245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PspS19_24250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PspS19_24255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PspS19_24260	COG0142	geranyltranstransferase activity
PspS19_24265	COG2824	Alkylphosphonate utilization operon protein PhnA
PspS19_24275	COG0545	Peptidyl-prolyl cis-trans isomerase
PspS19_24285	COG2862	Uncharacterized protein family, UPF0114
PspS19_24300	COG1067	ATP-dependent peptidase activity
PspS19_24330	COG0488	(ABC) transporter
PspS19_24340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PspS19_24365	COG0523	cobalamin synthesis protein
PspS19_24370	COG2879	small protein
PspS19_24375	COG1966	Carbon starvation protein
PspS19_24390	COG1970	mechanosensitive ion channel activity
PspS19_24400	COG2197	response regulator
PspS19_24405	COG2813	Specifically methylates the guanine in position
PspS19_24415	COG1294	oxidase, subunit
PspS19_24420	COG1271	oxidase subunit
PspS19_24440	COG2252	PERMEase
PspS19_24445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PspS19_24460	COG1309	transcriptional regulator
PspS19_24465	COG2321	neutral zinc metallopeptidase
PspS19_24470	COG2321	neutral zinc metallopeptidase
PspS19_24475	COG0546	phosphoglycolate phosphatase activity
PspS19_24480	COG1946	Acyl-CoA thioesterase
PspS19_24490	COG0123	including yeast histone deacetylase and acetoin utilization protein
PspS19_24500	COG0513	Belongs to the DEAD box helicase family
PspS19_24505	COG0697	spore germination
PspS19_24510	COG1522	sequence-specific DNA binding
PspS19_24515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PspS19_24515	COG1199	ATP-dependent helicase activity
PspS19_24525	COG3416	Protein conserved in bacteria
PspS19_24540	COG1643	Atp-dependent helicase
PspS19_24550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PspS19_24555	COG1522	sequence-specific DNA binding
PspS19_24570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PspS19_24580	COG1960	acyl-CoA dehydrogenase activity
PspS19_24590	COG0351	phosphomethylpyrimidine kinase
PspS19_24595	COG0352	thiamine-phosphate diphosphorylase activity
PspS19_24600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PspS19_24615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PspS19_24620	COG1702	phosphate starvation-inducible protein PhoH
PspS19_24625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PspS19_24630	COG4535	Mg2 and Co2 transporter CorC
PspS19_24635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PspS19_24650	COG0495	leucyl-tRNA aminoacylation
PspS19_24670	COG2951	lytic endotransglycosylase activity
PspS19_24675	COG1619	proteins homologs of microcin C7 resistance protein MccF
PspS19_24680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PspS19_24685	COG0321	lipoyl(octanoyl) transferase activity
PspS19_24690	COG2921	Belongs to the UPF0250 family
PspS19_24695	COG1686	Belongs to the peptidase S11 family
PspS19_24705	COG2951	lytic endotransglycosylase activity
PspS19_24710	COG0772	Belongs to the SEDS family
PspS19_24715	COG0768	penicillin binding
PspS19_24720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PspS19_24730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PspS19_24735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PspS19_24740	COG2094	Belongs to the DNA glycosylase MPG family
PspS19_24745	COG0586	Pfam SNARE associated Golgi protein
PspS19_24755	COG1346	cytolysis
PspS19_24775	COG0702	epimerase
PspS19_24790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PspS19_24800	COG3284	Transcriptional regulator
PspS19_24805	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_24815	COG4303	Ethanolamine ammonia lyase large subunit
PspS19_24820	COG4302	ethanolamine ammonia-lyase activity
PspS19_24825	COG0456	acetyltransferase
PspS19_24830	COG0586	Pfam SNARE associated Golgi protein
PspS19_24840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PspS19_24850	COG0464	growth
PspS19_24860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspS19_24875	COG3706	GGDEF domain
PspS19_24880	COG1722	exodeoxyribonuclease VII activity
PspS19_24885	COG0142	geranyltranstransferase activity
PspS19_24890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PspS19_24895	COG4206	TonB-dependent receptor
PspS19_24900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PspS19_24910	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PspS19_24920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PspS19_24925	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PspS19_24930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PspS19_24935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PspS19_24950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PspS19_24950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PspS19_24965	COG2264	protein methyltransferase activity
PspS19_24970	COG3118	belongs to the thioredoxin family
PspS19_25000	COG3047	cAMP biosynthetic process
PspS19_25015	COG1201	RNA secondary structure unwinding
PspS19_25020	COG0668	transmembrane transport
PspS19_25025	COG3568	Endonuclease Exonuclease Phosphatase
PspS19_25030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspS19_25035	COG0392	lysyltransferase activity
PspS19_25050	COG1917	Cupin 2, conserved barrel domain protein
PspS19_25050	COG2169	Transcriptional regulator
PspS19_25055	COG1335	isochorismatase
PspS19_25065	COG0629	single-stranded DNA binding
PspS19_25070	COG2814	Major facilitator Superfamily
PspS19_25075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PspS19_25080	COG2193	ferroxidase activity
PspS19_25090	COG0203	ribosomal protein L17
PspS19_25095	COG0202	RNA polymerase activity
PspS19_25100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PspS19_25105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PspS19_25110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PspS19_25120	COG0200	Binds to the 23S rRNA
PspS19_25125	COG1841	ribosomal large subunit assembly
PspS19_25130	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PspS19_25135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PspS19_25140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PspS19_25145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PspS19_25150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PspS19_25155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PspS19_25160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PspS19_25165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PspS19_25170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PspS19_25175	COG0255	Belongs to the universal ribosomal protein uL29 family
PspS19_25180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PspS19_25185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PspS19_25195	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PspS19_25200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PspS19_25205	COG0089	rRNA binding
PspS19_25210	COG0088	Forms part of the polypeptide exit tunnel
PspS19_25215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PspS19_25220	COG0051	transcription antitermination factor activity, RNA binding
PspS19_25225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PspS19_25230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PspS19_25235	COG0049	tRNA binding
PspS19_25240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PspS19_25245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PspS19_25250	COG0085	RNA polymerase activity
PspS19_25255	COG0222	ribosome binding
PspS19_25260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PspS19_25265	COG0081	regulation of translation
PspS19_25270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PspS19_25290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PspS19_25315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PspS19_25355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PspS19_25360	COG0739	heme binding
PspS19_25365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PspS19_25370	COG0316	Belongs to the HesB IscA family
PspS19_25375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PspS19_25400	COG0537	adenosine 5'-monophosphoramidase activity
PspS19_25405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PspS19_25410	COG1765	OsmC-like protein
PspS19_25420	COG0095	Lipoate-protein ligase
PspS19_25425	COG0134	indole-3-glycerol-phosphate synthase activity
PspS19_25430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PspS19_25435	COG0512	Glutamine amidotransferase of anthranilate synthase
PspS19_25445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PspS19_25450	COG0546	phosphoglycolate phosphatase activity
PspS19_25455	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PspS19_25460	COG1454	alcohol dehydrogenase
PspS19_25470	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_25480	COG3842	ATPase activity
PspS19_25485	COG2197	response regulator
PspS19_25490	COG4585	Histidine kinase
PspS19_25500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PspS19_25505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PspS19_25510	COG3178	'Phosphotransferase
PspS19_25515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PspS19_25520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PspS19_25525	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PspS19_25530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PspS19_25535	COG2967	ApaG domain
PspS19_25540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PspS19_25545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PspS19_25550	COG2766	serine protein kinase
PspS19_25555	COG2718	Belongs to the UPF0229 family
PspS19_25560	COG2719	SpoVR family
PspS19_25565	COG0617	tRNA 3'-terminal CCA addition
PspS19_25575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PspS19_25580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PspS19_25585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PspS19_25590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PspS19_25595	COG0358	DNA primase activity
PspS19_25600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PspS19_25615	COG2026	Addiction module toxin, RelE StbE family
PspS19_25620	COG3077	Addiction module antitoxin, RelB DinJ family
PspS19_25650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PspS19_25655	COG1025	Belongs to the peptidase M16 family
PspS19_25665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PspS19_25670	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
PspS19_25680	COG0535	radical SAM domain protein
PspS19_25705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PspS19_25710	COG2258	MOSC domain
PspS19_25715	COG0583	DNA-binding transcription factor activity
PspS19_25720	COG1960	acyl-CoA dehydrogenase activity
PspS19_25725	COG1960	acyl-CoA dehydrogenase activity
PspS19_25730	COG3706	GGDEF domain
PspS19_25735	COG1960	acyl-CoA dehydrogenase activity
PspS19_25750	COG1073	alpha beta
PspS19_25750	COG2226	methyltransferase
PspS19_25755	COG0156	8-amino-7-oxononanoate synthase activity
PspS19_25760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PspS19_25765	COG1040	competence protein
PspS19_25770	COG3585	molybdate ion transport
PspS19_25770	COG2005	Transcriptional regulator
PspS19_25780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PspS19_25795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PspS19_25815	COG1595	DNA-templated transcription, initiation
PspS19_25820	COG3712	iron ion homeostasis
PspS19_25825	COG4774	siderophore transport
PspS19_25855	COG4452	Inner membrane protein CreD
PspS19_25860	COG2205	protein histidine kinase activity
PspS19_25865	COG0745	RESPONSE REGULATOR receiver
PspS19_25875	COG4067	protein conserved in archaea
PspS19_25875	COG0189	ligase activity
PspS19_25880	COG0204	Acyl-transferase
PspS19_25890	COG1063	alcohol dehydrogenase
PspS19_25920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PspS19_25940	COG1017	nitric oxide dioxygenase activity
PspS19_25940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PspS19_25945	COG4638	Rieske (2fe-2S)
PspS19_25960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PspS19_25965	COG2181	nitrate reductase activity
PspS19_25965	COG0247	lactate metabolic process
PspS19_25970	COG0446	pyridine nucleotide-disulphide oxidoreductase
PspS19_25970	COG1902	pentaerythritol trinitrate reductase activity
PspS19_26005	COG3246	L-lysine catabolic process to acetate
PspS19_26010	COG1250	3-hydroxyacyl-CoA dehydrogenase
PspS19_26035	COG1760	l-serine dehydratase
PspS19_26050	COG4175	Glycine betaine
PspS19_26055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PspS19_26060	COG1309	transcriptional regulator
PspS19_26065	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_26070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PspS19_26075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PspS19_26085	COG0312	modulator of DNA gyrase
PspS19_26090	COG0477	Major facilitator Superfamily
PspS19_26095	COG0513	Belongs to the DEAD box helicase family
PspS19_26100	COG2081	HI0933 family
PspS19_26105	COG1289	transmembrane transporter activity
PspS19_26115	COG2153	protein acetylation
PspS19_26125	COG1451	nucleotide metabolic process
PspS19_26160	COG0126	phosphoglycerate kinase activity
PspS19_26165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PspS19_26170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PspS19_26175	COG0640	Transcriptional regulator
PspS19_26180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PspS19_26185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PspS19_26190	COG1422	Protein of unknown function (DUF1090)
PspS19_26215	COG2814	Major facilitator Superfamily
PspS19_26235	COG2116	formate transmembrane transporter activity
PspS19_26245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PspS19_26250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PspS19_26265	COG0513	Belongs to the DEAD box helicase family
PspS19_26270	COG2353	YceI-like domain
PspS19_26275	COG3038	cytochrome b561
PspS19_26285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PspS19_26290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_26310	COG1272	protein, Hemolysin III
PspS19_26350	COG0189	ligase activity
PspS19_26360	COG1678	Uncharacterized ACR, COG1678
PspS19_26365	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PspS19_26370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PspS19_26375	COG0540	Belongs to the ATCase OTCase family
PspS19_26380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PspS19_26390	COG0791	NLP P60 protein
PspS19_26415	COG1872	DUF167
PspS19_26420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspS19_26425	COG2813	Specifically methylates the guanine in position
PspS19_26425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PspS19_26435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PspS19_26440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PspS19_26450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PspS19_26455	COG2022	thiamine diphosphate biosynthetic process
PspS19_26465	COG2363	Small membrane protein
PspS19_26470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PspS19_26480	COG2177	Part of the ABC transporter FtsEX involved in
PspS19_26485	COG2884	Cell division ATP-binding protein ftsE
PspS19_26490	COG0552	protein localization to endoplasmic reticulum
PspS19_26495	COG0612	Peptidase, M16
PspS19_26500	COG0612	Peptidase, M16
PspS19_26505	COG0742	ribosomal rna small subunit methyltransferase
PspS19_26510	COG0612	Peptidase, M16
PspS19_26515	COG0612	Peptidase, M16
PspS19_26520	COG0429	hydrolase of the alpha beta-hydrolase fold
PspS19_26530	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PspS19_26560	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
PspS19_26565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PspS19_26570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PspS19_26575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PspS19_26600	COG0129	dihydroxy-acid dehydratase activity
PspS19_26625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PspS19_26630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PspS19_26650	COG1840	ABC-type Fe3 transport system, periplasmic component
PspS19_26655	COG1178	ABC-type Fe3 transport system permease component
PspS19_26660	COG3842	ATPase activity
PspS19_26665	COG0583	DNA-binding transcription factor activity
PspS19_26675	COG0789	Transcriptional regulator
PspS19_26680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PspS19_26685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PspS19_26690	COG0730	response to heat
PspS19_26700	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PspS19_26705	COG0494	nUDIX hydrolase
PspS19_26720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PspS19_26725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PspS19_26730	COG3204	pilus organization
PspS19_26735	COG0179	Fumarylacetoacetate (FAA) hydrolase
PspS19_26740	COG0277	FAD linked oxidase domain protein
PspS19_26750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PspS19_26765	COG1683	Conserved Protein
PspS19_26805	COG1177	transmembrane transport
PspS19_26810	COG1176	ABC-type spermidine putrescine transport system, permease component I
PspS19_26815	COG3842	ATPase activity
PspS19_26840	COG0174	glutamine synthetase
PspS19_26845	COG0174	glutamine synthetase
PspS19_26860	COG1116	anion transmembrane transporter activity
PspS19_26865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PspS19_26870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PspS19_26875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PspS19_26880	COG0431	NADPH-dependent FMN reductase
PspS19_26885	COG0450	alkyl hydroperoxide reductase
PspS19_26895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PspS19_26895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PspS19_26910	COG1522	sequence-specific DNA binding
PspS19_26925	COG0330	HflC and HflK could
PspS19_26930	COG1585	Membrane protein implicated in regulation of membrane protease activity
PspS19_26940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspS19_26940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PspS19_26945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PspS19_26950	COG0509	glycine decarboxylation via glycine cleavage system
PspS19_26955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PspS19_26960	COG1178	ABC-type Fe3 transport system permease component
PspS19_26970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PspS19_26980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PspS19_26985	COG0006	proline dipeptidase activity
PspS19_26990	COG3079	Belongs to the UPF0149 family
PspS19_27010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PspS19_27020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PspS19_27025	COG0842	Transport permease protein
PspS19_27025	COG1129	ABC transporter
PspS19_27030	COG0842	Transport permease protein
PspS19_27065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PspS19_27085	COG0248	Ppx GppA phosphatase
PspS19_27090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PspS19_27100	COG0586	Pfam SNARE associated Golgi protein
PspS19_27110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
PspS19_27115	COG1671	Belongs to the UPF0178 family
PspS19_27120	COG0672	)-iron permease
PspS19_27135	COG0488	(ABC) transporter
PspS19_27165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PspS19_27185	COG0181	hydroxymethylbilane synthase activity
PspS19_27195	COG0165	Argininosuccinate lyase
PspS19_27200	COG0625	glutathione transferase activity
PspS19_27220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspS19_27230	COG1965	Belongs to the frataxin family
PspS19_27240	COG0019	diaminopimelate decarboxylase activity
PspS19_27245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PspS19_27255	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PspS19_27260	COG1011	Hydrolase
PspS19_27270	COG0432	Pfam Uncharacterised protein family UPF0047
PspS19_27275	COG0004	ammonium transporteR
PspS19_27280	COG0347	Belongs to the P(II) protein family
PspS19_27290	COG0606	chelatase, subunit chli
PspS19_27295	COG0583	DNA-binding transcription factor activity
PspS19_27300	COG0534	Mate efflux family protein
PspS19_27315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PspS19_27320	COG0427	acetyl-CoA hydrolase
PspS19_27335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PspS19_27340	COG0251	oxidation-reduction process
PspS19_27345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_27350	COG1522	sequence-specific DNA binding
PspS19_27360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PspS19_27370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PspS19_27375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspS19_27385	COG1012	belongs to the aldehyde dehydrogenase family
PspS19_27400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PspS19_27405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PspS19_27410	COG0747	negative chemotaxis
PspS19_27415	COG2003	Belongs to the UPF0758 family
PspS19_27420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PspS19_27425	COG0756	dUTP diphosphatase activity
PspS19_27430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PspS19_27435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PspS19_27440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PspS19_27445	COG0708	Exodeoxyribonuclease III
PspS19_27455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PspS19_27460	COG1561	YicC-like family, N-terminal region
PspS19_27465	COG0194	GDP metabolic process
PspS19_27470	COG1758	RNA polymerase activity
PspS19_27475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PspS19_27500	COG0848	biopolymer transport protein
PspS19_27510	COG0583	DNA-binding transcription factor activity
PspS19_27515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PspS19_27545	COG3161	chorismate lyase activity
PspS19_27550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PspS19_27570	COG1253	flavin adenine dinucleotide binding
PspS19_27575	COG0739	heme binding
PspS19_27585	COG0704	Plays a role in the regulation of phosphate uptake
PspS19_27590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PspS19_27595	COG0581	inorganic phosphate transmembrane transporter activity
PspS19_27610	COG0477	Major facilitator Superfamily
PspS19_27615	COG1607	acyl-coa hydrolase
PspS19_27650	COG0583	DNA-binding transcription factor activity
PspS19_27655	COG1027	Aspartate ammonia-lyase
PspS19_27665	COG1115	amino acid carrier protein
PspS19_27670	COG0252	asparaginase activity
PspS19_27720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PspS19_27725	COG0765	amino acid transport
PspS19_27740	COG0511	ligase activity, forming carbon-carbon bonds
PspS19_27740	COG5016	pyruvate
PspS19_27745	COG0439	Biotin carboxylase
PspS19_27750	COG0583	DNA-binding transcription factor activity
PspS19_27775	COG0210	DNA helicase
PspS19_27790	COG4651	solute:proton antiporter activity
PspS19_27790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PspS19_27795	COG1607	acyl-coa hydrolase
PspS19_27800	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PspS19_27810	COG0523	cobalamin synthesis protein
PspS19_27830	COG1469	GTP cyclohydrolase I activity
PspS19_27840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PspS19_27845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PspS19_27845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PspS19_27855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PspS19_27860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PspS19_27880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PspS19_27880	COG2755	lipolytic protein G-D-S-L family
PspS19_27930	COG0438	transferase activity, transferring glycosyl groups
PspS19_27945	COG0625	glutathione transferase activity
PspS19_27950	COG0583	DNA-binding transcription factor activity
PspS19_27955	COG2814	Major facilitator Superfamily
PspS19_27960	COG0583	DNA-binding transcription factor activity
PspS19_27965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PspS19_27970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PspS19_27975	COG1349	DNA-binding transcription factor activity
PspS19_27980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PspS19_27985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PspS19_27990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PspS19_27995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PspS19_28000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PspS19_28005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PspS19_28010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PspS19_28020	COG0356	it plays a direct role in the translocation of protons across the membrane
PspS19_28025	COG3312	ion transport
PspS19_28030	COG1475	DNA binding
PspS19_28035	COG1192	Involved in chromosome partitioning
PspS19_28040	COG0357	Ribosomal RNA small subunit methyltransferase G
PspS19_28045	COG0445	tRNA wobble uridine modification
PspS19_28050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PspS19_28055	COG0706	membrane insertase activity
PspS19_28060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PspS19_28065	COG0594	ribonuclease P activity
PspS19_28070	COG0230	Belongs to the bacterial ribosomal protein bL34 family