locus-tag class description CH92_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CH92_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CH92_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CH92_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH92_00025 ENOG4108JU3 Alkyl hydroperoxide reductase CH92_00035 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CH92_00040 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CH92_00045 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CH92_00050 ENOG4108R3E Dna-3-methyladenine glycosylase i CH92_00065 ENOG4105WAP TPR repeat-containing protein CH92_00090 ENOG4107SQD Transcriptional regulator, GntR family CH92_00105 ENOG4105ENR peptidase, M24 CH92_00110 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase CH92_00115 ENOG4108RYR transcriptional regulator AsnC family CH92_00120 ENOG4105EX9 Membrane CH92_00125 ENOG4105C26 Dehydrogenase CH92_00130 ENOG4105C8Y Acetylornithine aminotransferase CH92_00135 ENOG4105C1A potassium transporter peripheral membrane CH92_00140 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CH92_00145 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CH92_00150 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CH92_00155 ENOG4108WZM domain protein CH92_00165 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH92_00170 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CH92_00175 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CH92_00180 ENOG4105E2X shikimate dehydrogenase CH92_00195 ENOG41061WM D-Alanyl-D-Alanine CH92_00235 ENOG41082W1 Cupin 2, conserved barrel domain protein CH92_00265 ENOG41082W1 Cupin 2, conserved barrel domain protein CH92_00290 ENOG4105BZ1 (ABC) transporter CH92_00300 ENOG4107UIE peptidase CH92_00325 ENOG4105CYM Glutathione S-transferase CH92_00330 ENOG4105CPC Aldo Keto reductase CH92_00355 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CH92_00365 ENOG4108MGI Transcriptional regulator CH92_00370 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CH92_00375 ENOG4105CMR udp-glucose 4-epimerase CH92_00395 ENOG4105BZ1 (ABC) transporter CH92_00400 ENOG41087WU CH92_00405 ENOG4105WKW Pfam:DUF1458 CH92_00415 ENOG4105DEN Luciferase family CH92_00450 ENOG4107XGZ Hydrolase CH92_00455 ENOG4108Z0R Transferase CH92_00460 ENOG4105R1U AraC Family Transcriptional Regulator CH92_00465 ENOG4105DHU Bile acid CH92_00470 ENOG4105DGW oligopeptidase A CH92_00495 ENOG4107B2H carbonic anhydrase CH92_00500 ENOG4105CHH sulfate transporter CH92_00515 ENOG4105BZ9 Cytochrome C oxidase, subunit I CH92_00520 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) CH92_00525 ENOG4107QS1 Cytochrome C Oxidase, Subunit III CH92_00550 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CH92_00560 ENOG4107ENK receptor CH92_00565 ENOG4106QJH hemin transport protein CH92_00575 ENOG4105EHG Permease protein CH92_00605 ENOG4105D01 (LipO)protein CH92_00610 ENOG4108UMI ABC transporter, permease CH92_00625 ENOG4108VKG metal-dependent hydrolase CH92_00630 ENOG4105FAV ABC, transporter CH92_00635 ENOG4105FDK ABC transporter CH92_00640 ENOG4105MYN Zinc uptake regulation protein CH92_00645 ENOG4105NXV High-affinity zinc uptake system protein CH92_00660 ENOG4105EWT decarboxylase family CH92_00675 ENOG4105C2M dna polymerase I CH92_00710 ENOG4105NF4 modulator of drug activity CH92_00715 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH92_00720 ENOG4105W8H transhydrogenase (subunit alpha CH92_00725 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH92_00730 ENOG4107QHF type ii secretion system protein e CH92_00735 ENOG4105D7Q type ii secretion system CH92_00740 ENOG4108VAU general secretion pathway protein G CH92_00745 ENOG4105VWV general secretion pathway protein h CH92_00750 ENOG4105X5Z General secretion pathway protein I CH92_00755 ENOG4108WWZ General secretion pathway protein J CH92_00760 ENOG4108RTD type II secretion system protein K CH92_00765 ENOG4108ADH Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) CH92_00780 ENOG4105CB5 ATP-dependent DNA helicase recG CH92_00785 ENOG4105C5Q Transcriptional regulator CH92_00860 ENOG4105GRZ Ycii-related protein CH92_00865 ENOG4105CHP RNA polymerase CH92_00880 ENOG4105CHH sulfate transporter CH92_00890 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CH92_00910 ENOG4105EM7 Selenocysteine-specific translation elongation factor CH92_00915 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CH92_00925 ENOG4105CH5 extracellular solute-binding protein, family 7 CH92_00930 ENOG4105C4R Atp-dependent dna helicase CH92_00940 ENOG4105BZU Histidine kinase CH92_00960 ENOG4105CZK Aspartate kinase CH92_00965 ENOG4105EV8 ectoine hydroxylase CH92_00970 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) CH92_00985 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CH92_01000 ENOG4105DG4 malate L-lactate dehydrogenase CH92_01005 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_01015 ENOG4108ERU trap dicarboxylate transporter subunit DctP CH92_01020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH92_01025 ENOG4105CTU Proline racemase CH92_01035 ENOG4105E5Q amino acid AbC transporter CH92_01040 ENOG4108HW4 amino acid AbC transporter CH92_01050 ENOG4105EAB amino acid AbC transporter CH92_01075 ENOG4105CTU Proline racemase CH92_01085 ENOG4105DUM transcriptional regulator, lysR family CH92_01090 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CH92_01095 ENOG4107QSA Oxaloacetate decarboxylase CH92_01110 ENOG4105CSV Glutaminase CH92_01115 ENOG4107B2H carbonic anhydrase CH92_01135 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CH92_01140 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 CH92_01170 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CH92_01175 ENOG41067ZM Uncharacterised protein family (UPF0158) CH92_01190 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CH92_01200 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase CH92_01205 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CH92_01210 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CH92_01220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CH92_01235 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CH92_01245 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CH92_01255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_01260 ENOG4105CUX Signal transduction histidine kinase CH92_01275 ENOG4105C5F glutamine synthetase CH92_01280 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CH92_01295 ENOG4105BZU Histidine kinase CH92_01305 ENOG4105F04 LysR family Transcriptional regulator CH92_01325 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CH92_01340 ENOG4108MRH transcriptional regulatory protein CH92_01345 ENOG4105C8Q Methyl-accepting chemotaxis CH92_01365 ENOG4105NIV Esterase CH92_01385 ENOG4106NZI LysR family Transcriptional regulator CH92_01430 ENOG4105DZ0 fad dependent oxidoreductase CH92_01440 ENOG4105DKB L-sorbosone dehydrogenase CH92_01445 ENOG4105N7H Cytochrome CH92_01450 ENOG4108W15 Protein of unknown function (DUF1456) CH92_01465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_01470 ENOG4108K0B C-di-gmp phosphodiesterase CH92_01475 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein CH92_01510 ENOG4108HPI phosphatidate Cytidylyltransferase CH92_01520 ENOG4105DWF phosphomethylpyrimidine kinase CH92_01540 ENOG4105KJM monovalent cation h antiporter subunit g CH92_01555 ENOG4108JPZ Monovalent cation H antiporter subunit D CH92_01560 ENOG4108JPZ Monovalent cation H antiporter subunit D CH92_01565 ENOG4105C8S subunit m CH92_01570 ENOG4105C8Q Methyl-accepting chemotaxis CH92_01585 ENOG4107JEE Short-chain dehydrogenase reductase Sdr CH92_01640 ENOG4108JQ1 Dehydrogenase CH92_01645 ENOG4105CQB FAD linked oxidase domain protein CH92_01650 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CH92_01660 ENOG4108ZK4 sdia-regulated domain-containing protein CH92_01665 ENOG4105E66 phosphoriboisomerase A CH92_01670 ENOG4105C7B Threonine dehydratase CH92_01690 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CH92_01695 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CH92_01705 ENOG4105HF0 Membrane CH92_01710 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CH92_01715 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CH92_01720 ENOG4107SKI cobyrinic Acid a,c-diamide synthase CH92_01730 ENOG4105C32 Amino acid ABC transporter (Permease) CH92_01735 ENOG4108IV0 ABC, transporter CH92_01740 ENOG4105C0Z ABC transporter CH92_01750 ENOG4108VYJ response regulator receiver protein CH92_01755 ENOG4105DR5 peptidase CH92_01765 ENOG4105C37 (CBS) domain CH92_01770 ENOG4105BZU Histidine kinase CH92_01775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CH92_01780 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) CH92_01785 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CH92_01790 ENOG4108KWP DNA-binding transcriptional regulator GlcC CH92_01795 ENOG4105CQB FAD linked oxidase domain protein CH92_01800 ENOG4105EU8 FAD linked oxidase domain protein CH92_01805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CH92_01810 ENOG4108ZJF Glcg protein CH92_01815 ENOG4107QP3 malate synthase g CH92_01820 ENOG4105DAA L-lactate CH92_01830 ENOG4107QZF nitrite reductase NADPH large subunit CH92_01835 ENOG4105NYX DNA-binding protein CH92_01850 ENOG4105BZS acriflavin resistance protein CH92_01860 ENOG4105GR3 Histidine kinase CH92_01870 ENOG4105ETT transcriptional Regulator, LysR family CH92_01875 ENOG4105C1G acyl-Coa dehydrogenase CH92_01880 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CH92_01885 ENOG4108V0P LemA family CH92_01900 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CH92_01910 ENOG4105D1F ATP-binding protein CH92_01915 ENOG4105DP0 ferredoxin-NADP reductase CH92_01935 ENOG4108Z4U Ferredoxin CH92_01955 ENOG4105FDP GntR family transcriptional regulator CH92_01965 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CH92_01980 ENOG4105DHT Metal Dependent Phosphohydrolase CH92_01990 ENOG4108ZG0 Ompa motb domain protein CH92_01995 ENOG4108T5G Adenylate CH92_02000 ENOG4105KME endoribonuclease L-psp CH92_02005 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH92_02010 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CH92_02015 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CH92_02020 ENOG4105DSJ YicC domain protein CH92_02025 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CH92_02035 ENOG4105CGK Exodeoxyribonuclease III CH92_02040 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CH92_02050 ENOG4105CAS nag kinase CH92_02060 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CH92_02065 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CH92_02070 ENOG4105W5Q DNA repair protein (RadC CH92_02080 ENOG4108VUY thioesterase Superfamily protein CH92_02085 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH92_02105 ENOG4107RZC phospholipase d CH92_02110 ENOG4105CJP fad dependent oxidoreductase CH92_02115 ENOG4105EW9 transcriptional regulator AsnC family CH92_02120 ENOG4105MWK D-amino acid dehydrogenase, small subunit CH92_02135 ENOG4105MPD Cytochrome CH92_02145 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CH92_02165 ENOG4105CG3 alpha amylase, catalytic region CH92_02170 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH92_02180 ENOG4105C0A alcohol dehydrogenase CH92_02185 ENOG4105C26 Dehydrogenase CH92_02190 ENOG4108FUF Transcriptional regulator, IclR family CH92_02195 ENOG4105C4R Atp-dependent dna helicase CH92_02200 ENOG4105BZU Histidine kinase CH92_02205 ENOG4105C94 Transporter CH92_02210 ENOG4105C0P Mg chelatase subunit ChlI CH92_02215 ENOG4105W0Z cytoplasmic protein CH92_02220 ENOG4108YZA Nitrogen regulatory protein pii CH92_02225 ENOG4105BZU Histidine kinase CH92_02235 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CH92_02250 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH92_02260 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CH92_02265 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CH92_02275 ENOG4105XQ6 frataxin-like protein CH92_02280 ENOG4105NXH GreA GreB family elongation factor CH92_02285 ENOG4107T0K Adenylate cyclase CH92_02300 ENOG4107QUT magnesium and cobalt transport protein CorA CH92_02320 ENOG4105CH7 arginosuccinase CH92_02325 ENOG4105C8Q Methyl-accepting chemotaxis CH92_02335 ENOG4108NEV two component transcriptional regulator, LytTR family CH92_02345 ENOG41076E6 Uroporphyrinogen-III Synthase CH92_02360 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) CH92_02365 ENOG4105PBF Anti-RNA polymerase sigma 70 factor CH92_02380 ENOG4105C5H ABC transporter CH92_02390 ENOG4105EE5 Membrane protein terC CH92_02395 ENOG410829K Lysine exporter protein (Lyse ygga) CH92_02400 ENOG4108UPT UPF0178 protein CH92_02405 ENOG4108VUY thioesterase Superfamily protein CH92_02410 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain CH92_02415 ENOG4105D52 delta-aminolevulinic acid dehydratase CH92_02420 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CH92_02425 ENOG4105C9X ppx gppa phosphatase CH92_02430 ENOG4105K63 Thioredoxin CH92_02435 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CH92_02440 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CH92_02455 ENOG4105C75 arginyL-tRNA synthetase CH92_02460 ENOG4105C25 Primosomal protein n' CH92_02465 ENOG4105VFB Binds the 23S rRNA (By similarity) CH92_02475 ENOG4105C6K Malic enzyme CH92_02480 ENOG4108JQC penicillin-binding protein 1A CH92_02505 ENOG4105E4G Type IV pilus CH92_02510 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CH92_02515 ENOG4105D49 3-dehydroquinate synthase CH92_02525 ENOG4105CBC glutamate synthase CH92_02530 ENOG4105BZ8 glutamate synthase CH92_02550 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH92_02555 ENOG4105C2D reductase CH92_02565 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH92_02595 ENOG4105C84 Histidine ammonia-lyase CH92_02625 ENOG4107IQ5 Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CH92_02640 ENOG4105K63 Thioredoxin CH92_02650 ENOG4105EQ0 Major Facilitator superfamily CH92_02720 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CH92_02725 ENOG4105VCC 30S ribosomal protein S21 CH92_02730 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH92_02735 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CH92_02755 ENOG4105ED1 spovr family CH92_02760 ENOG4106AKX UPF0229 protein CH92_02765 ENOG4105CYN Serine protein kinase CH92_02770 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CH92_02775 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CH92_02780 ENOG4105NWN ApaG protein CH92_02785 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CH92_02790 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CH92_02795 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CH92_02800 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CH92_02805 ENOG4105EHM Aminoglycoside phosphotransferase CH92_02810 ENOG4108S0S Nucleotidyl transferase CH92_02825 ENOG4105BZU Histidine kinase CH92_02830 ENOG4105WH1 Two component transcriptional regulator luxr family CH92_02835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH92_02845 ENOG4105F38 ABC transporter, permease CH92_02855 ENOG4108JPW Aminotransferase CH92_02860 ENOG4105DJV ribulose-phosphate 3-epimerase CH92_02865 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CH92_02870 ENOG4105CRQ synthase (Component I) CH92_02875 ENOG4105DDQ anthranilate synthase CH92_02880 ENOG4108I0Q anthranilate phosphoribosyltransferase CH92_02885 ENOG4105DK0 Indole-3-glycerol phosphate synthase CH92_02890 ENOG4107RYR Transcriptional regulator, Crp Fnr family CH92_02895 ENOG4108UKZ OsmC family CH92_02905 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) CH92_02910 ENOG4107YU2 histidine triad (hIT) protein CH92_02915 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CH92_02925 ENOG4105EA8 2-Nitropropane dioxygenase CH92_02930 ENOG4108YXA Membrane CH92_02935 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CH92_02940 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CH92_02945 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CH92_02950 ENOG4105DR5 peptidase CH92_02955 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CH92_03030 ENOG4105D9P serine threonine protein kinase CH92_03090 ENOG4108JUA Transcriptional regulator CH92_03095 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH92_03165 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CH92_03170 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CH92_03205 ENOG4105PM1 preprotein translocase subunit SecE CH92_03210 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CH92_03220 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CH92_03230 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CH92_03235 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH92_03240 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH92_03245 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CH92_03250 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CH92_03255 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CH92_03265 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CH92_03270 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CH92_03275 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CH92_03280 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CH92_03285 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CH92_03290 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CH92_03300 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CH92_03305 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CH92_03310 ENOG41083MP 50s ribosomal protein l29 CH92_03315 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CH92_03320 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CH92_03325 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CH92_03330 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CH92_03335 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CH92_03340 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CH92_03345 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CH92_03355 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CH92_03360 ENOG4105VPB 50S ribosomal protein L30 CH92_03365 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CH92_03370 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CH92_03380 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CH92_03385 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CH92_03390 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CH92_03395 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH92_03400 ENOG4108ZT0 50S ribosomal protein l17 CH92_03410 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CH92_03415 ENOG4107RDB Major Facilitator CH92_03420 ENOG4108UUM single-stranded DNA-binding protein CH92_03430 ENOG4105C1B dTDP-glucose 4-6-dehydratase CH92_03435 ENOG4105EIF outer membrane protein W CH92_03455 ENOG4109015 Biopolymer transport protein exbD tolR CH92_03460 ENOG410822N TonB family CH92_03480 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH92_03495 ENOG4105CGZ zinc metallopeptidase CH92_03525 ENOG41080IJ Diacylglycerol kinase CH92_03535 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CH92_03540 ENOG4105C7N Xanthine uracil vitamin C permease CH92_03555 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit CH92_03560 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding CH92_03565 ENOG4105C7W Xanthine dehydrogenase CH92_03580 ENOG4105VUF Transcriptional regulator CH92_03585 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CH92_03590 ENOG4105DP0 ferredoxin-NADP reductase CH92_03600 ENOG4105CBG Sulfatase CH92_03625 ENOG4105J5J Outer membrane porin CH92_03640 ENOG4108HQS Glycine betaine CH92_03645 ENOG4108IJ7 Glycine betaine CH92_03655 ENOG4105EJQ L-serine dehydratase CH92_03660 ENOG4105ECQ AraC Family Transcriptional Regulator CH92_03680 ENOG4105C10 Electron transfer flavoprotein CH92_03685 ENOG4105DF6 Fe-S oxidoreductase CH92_03700 ENOG4108IGT Dipeptidase CH92_03705 ENOG4105ECQ AraC Family Transcriptional Regulator CH92_03715 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme CH92_03720 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CH92_03760 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CH92_03765 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH92_03775 ENOG4105DVW rieske (2Fe-2S) CH92_03780 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CH92_03785 ENOG4105BZU Histidine kinase CH92_03805 ENOG4105C5H ABC transporter CH92_03810 ENOG4105BZU Histidine kinase CH92_03815 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CH92_03840 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CH92_03855 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CH92_03865 ENOG4105DAN ATP-dependent protease CH92_03875 ENOG4108TEB UPF0114 protein CH92_03880 ENOG4108V1T peptidylprolyl cis-trans isomerase CH92_03890 ENOG4105EAH synthase CH92_03895 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CH92_03900 ENOG4105K46 50S ribosomal protein l27 CH92_03905 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CH92_03910 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CH92_03915 ENOG4108RH0 Crea protein CH92_03920 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CH92_03925 ENOG4105CJR Integral membrane protein (MviN CH92_03930 ENOG4105DTN riboflavin biosynthesis protein ribF CH92_03935 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CH92_03945 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CH92_03950 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CH92_03980 ENOG4105VWV general secretion pathway protein h CH92_03990 ENOG4108DN8 FAD dependent oxidoreductase CH92_03995 ENOG4108ZJT translation initiation factor, Sui1 CH92_04000 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) CH92_04005 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CH92_04015 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) CH92_04020 ENOG4108XM1 transcriptional regulator AsnC family CH92_04035 ENOG4105C8J )-transporter CH92_04040 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CH92_04045 ENOG4108RXX maleylacetoacetate isomerase CH92_04050 ENOG4105C8J )-transporter CH92_04055 ENOG4105C8Q Methyl-accepting chemotaxis CH92_04060 ENOG4107R7Y intracellular protease Pfpi family CH92_04075 ENOG4105CGF Aromatic amino acid aminotransferase CH92_04080 ENOG41090A4 Pterin carbinolamine dehydratase CH92_04085 ENOG4105MIR Phenylalanine 4-monooxygenase CH92_04090 ENOG4108JU8 Transcriptional regulator CH92_04095 ENOG4105BZU Histidine kinase CH92_04100 ENOG4105EJQ L-serine dehydratase CH92_04105 ENOG4105CAY ferredoxin--nadp reductase CH92_04110 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_04115 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_04120 ENOG4105C94 Transporter CH92_04135 ENOG4105K78 MarR family Transcriptional regulator CH92_04150 ENOG4105C1G acyl-Coa dehydrogenase CH92_04175 ENOG4108IJ8 ABC transporter CH92_04195 ENOG4105F64 nitrite reductase CH92_04200 ENOG4108JUA Transcriptional regulator CH92_04230 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH92_04250 ENOG4105ECQ AraC Family Transcriptional Regulator CH92_04280 ENOG4105CI2 imidazolone-5-propionate hydrolase CH92_04295 ENOG4105D25 secreted protein CH92_04300 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) CH92_04325 ENOG4105ERH Fumarylacetoacetate hydrolase CH92_04330 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase CH92_04365 ENOG4105D2S major facilitator superfamily CH92_04385 ENOG4105CTU Proline racemase CH92_04390 ENOG4105CIF Ornithine Cyclodeaminase CH92_04395 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_04405 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_04410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH92_04415 ENOG4105C26 Dehydrogenase CH92_04420 ENOG4105C26 Dehydrogenase CH92_04430 ENOG4105C54 Major Facilitator superfamily CH92_04435 ENOG4105II7 pyrroline-5-carboxylate reductase CH92_04450 ENOG4105KME endoribonuclease L-psp CH92_04465 ENOG4105CJP fad dependent oxidoreductase CH92_04470 ENOG4105C5I Dehydrogenase CH92_04475 ENOG4105C26 Dehydrogenase CH92_04480 ENOG4105CQB FAD linked oxidase domain protein CH92_04485 ENOG4105ETT transcriptional Regulator, LysR family CH92_04500 ENOG4105D25 secreted protein CH92_04505 ENOG4105EUZ Beta-lactamase domain protein CH92_04520 ENOG4105C1G acyl-Coa dehydrogenase CH92_04525 ENOG4105CEY Amp-dependent synthetase and ligase CH92_04530 ENOG4105CPW cytochrome b561 CH92_04550 ENOG4105DAA L-lactate CH92_04555 ENOG41073TP transcriptional regulator CH92_04560 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CH92_04565 ENOG4108Z1B Cyclase dehydrase CH92_04570 ENOG4105VDB UPF0125 protein CH92_04575 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH92_04580 ENOG41090R7 Ferric uptake CH92_04585 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CH92_04590 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CH92_04595 ENOG4105CFG Acts as a chaperone (By similarity) CH92_04600 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CH92_04605 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CH92_04615 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CH92_04620 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CH92_04630 ENOG4105HBR Rna-binding protein CH92_04635 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CH92_04640 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CH92_04645 ENOG4105EEI dihydropteroate synthase CH92_04650 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CH92_04655 ENOG4105CP7 Triose-phosphate isomerase CH92_04660 ENOG4105NTZ Preprotein translocase subunit SecG CH92_04675 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CH92_04680 ENOG4105CHV Transcription elongation factor NusA CH92_04690 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CH92_04695 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CH92_04700 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CH92_04705 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CH92_04710 ENOG4105W4M Transport-associated protein CH92_04740 ENOG4107QP8 phosphohexose isomerase CH92_04745 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CH92_04750 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CH92_04760 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CH92_04765 ENOG4105DJ0 Poly(A) Polymerase CH92_04775 ENOG4105BZU Histidine kinase CH92_04785 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CH92_04790 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CH92_04810 ENOG4108302 MgtC SapB transporter CH92_04825 ENOG4108URH decarboxylase CH92_04835 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr CH92_04840 ENOG4105CHH sulfate transporter CH92_04850 ENOG4105DWT malate dehydrogenase (quinone) CH92_04865 ENOG4105D25 secreted protein CH92_04895 ENOG4108K0D peptidase, M48 CH92_04910 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CH92_04915 ENOG4105C5I Dehydrogenase CH92_04925 ENOG4105CEY Amp-dependent synthetase and ligase CH92_04930 ENOG4105CQZ Histidine kinase CH92_04935 ENOG4105C5X domain protein CH92_04940 ENOG4108ZG0 Ompa motb domain protein CH92_04945 ENOG4105BZU Histidine kinase CH92_04950 ENOG4105BZU Histidine kinase CH92_04955 ENOG4106HNH Acyl-transferase CH92_04960 ENOG4105C6K Malic enzyme CH92_04965 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CH92_04970 ENOG4108YZY peptidylprolyl cis-trans isomerase CH92_04980 ENOG4108WUH Transcriptional regulator, TetR family CH92_04995 ENOG4105EXN Sulfate transport protein CysZ CH92_05015 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase CH92_05020 ENOG410642E Short chain dehydrogenase CH92_05030 ENOG4105QDK Flavodoxin CH92_05040 ENOG4108Z20 Acyl-transferase CH92_05060 ENOG4107R7Y intracellular protease Pfpi family CH92_05065 ENOG4105VYA Uncharacterized conserved protein (DUF2132) CH92_05070 ENOG4107GFK fumarate CH92_05075 ENOG4105BZU Histidine kinase CH92_05085 ENOG4105CA9 Pyruvate kinase CH92_05110 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CH92_05140 ENOG4105CJB Exodeoxyribonuclease I CH92_05160 ENOG4105D7A ATP-binding protein CH92_05170 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CH92_05175 ENOG4105D1Q UPF0246 protein CH92_05185 ENOG4108IAB Phoh family CH92_05190 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CH92_05195 ENOG4105M00 molybdopterin converting factor, subunit 1 CH92_05200 ENOG4108ZAF Molybdopterin CH92_05210 ENOG4105BZU Histidine kinase CH92_05215 ENOG4106CJB Phospholipase Carboxylesterase CH92_05225 ENOG4105EZ7 amino acid ABC transporter CH92_05230 ENOG4105DRP amino acid AbC transporter CH92_05235 ENOG4105CDA abc transporter atp-binding protein CH92_05240 ENOG4108ETH Formylglycinamide ribotide synthetase CH92_05250 ENOG4108ZHJ Organic hydroperoxide resistance protein CH92_05255 ENOG4105K56 Transcriptional regulator CH92_05260 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CH92_05265 ENOG4105E09 nadh pyrophosphatase CH92_05275 ENOG4108Z0R Transferase CH92_05285 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CH92_05290 ENOG4108JU6 CBS domain protein CH92_05295 ENOG4106KVJ cytochrome C assembly protein CH92_05300 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CH92_05305 ENOG4105K5M 30s ribosomal protein S16 CH92_05310 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CH92_05315 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CH92_05320 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CH92_05325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH92_05330 ENOG4105T95 Thiol disulfide interChange protein CH92_05335 ENOG4108Y50 Glutathione-dependent formaldehyde-activating Gfa CH92_05340 ENOG4105D6E homoserine dehydrogenase CH92_05345 ENOG4105D98 threonine synthase CH92_05350 ENOG4107XBN GntR Family Transcriptional Regulator CH92_05360 ENOG4108ERU trap dicarboxylate transporter subunit DctP CH92_05370 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_05375 ENOG4105E39 Enoyl-CoA hydratase CH92_05385 ENOG4105C5R Aminotransferase CH92_05390 ENOG4105CQB FAD linked oxidase domain protein CH92_05395 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CH92_05400 ENOG4105EKE dihydroorotase CH92_05410 ENOG4105DY2 Paraquat-inducible protein b CH92_05415 ENOG4105F1S paraquat-inducible protein a CH92_05420 ENOG4105H2K paraquat-inducible protein a CH92_05430 ENOG4105CDH Citrulline--aspartate ligase CH92_05445 ENOG4105CSM endonuclease III CH92_05455 ENOG4108UQQ Electron transport complex CH92_05460 ENOG4105D6A Electron transport complex CH92_05470 ENOG4108R3D Electron transport complex CH92_05475 ENOG4105DGN Electron transport complex CH92_05485 ENOG4105E39 Enoyl-CoA hydratase CH92_05495 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CH92_05510 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CH92_05515 ENOG4105Y75 tpr repeat protein CH92_05525 ENOG4108IYU L-aspartate oxidase CH92_05530 ENOG4105EMN RNA polymerase sigma factor CH92_05535 ENOG41069E1 anti sigma-E protein RseA CH92_05540 ENOG4105VQK sigma E regulatory protein, MucB RseB CH92_05545 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CH92_05550 ENOG4105C0H protease CH92_05555 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CH92_05560 ENOG4105C3F Signal peptidase i CH92_05570 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CH92_05575 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CH92_05580 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CH92_05585 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CH92_05590 ENOG41061AI Protein of unknown function (DUF2905) CH92_05605 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CH92_05610 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) CH92_05620 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CH92_05630 ENOG4105C26 Dehydrogenase CH92_05635 ENOG4105CK7 Sodium proline symporter CH92_05645 ENOG4105CK7 Sodium proline symporter CH92_05690 ENOG41068WC Domain of unknown function (DUF955) CH92_05705 ENOG4105I08 Pseudouridine synthase CH92_05710 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CH92_05725 ENOG4105DHP deoxycytidine triphosphate deaminase CH92_05730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH92_05740 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CH92_05755 ENOG4108FHP Autotransporter beta-domain CH92_05760 ENOG4107RH7 Nicotinate phosphoribosyltransferase CH92_05775 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH92_05790 ENOG4105CA9 Pyruvate kinase CH92_05800 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CH92_05805 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CH92_05810 ENOG41060W2 glyoxylate carboligase CH92_05815 ENOG4105EJC lysr family transcriptional regulator CH92_05820 ENOG4105VT2 5-hydroxyisourate hydrolase CH92_05840 ENOG4105CGK Exodeoxyribonuclease III CH92_05845 ENOG4105BZU Histidine kinase CH92_05860 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH92_05880 ENOG4105CF7 AraC family transcriptional regulator CH92_05885 ENOG4105DDY UPF0142 protein ycaO CH92_05925 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH92_05930 ENOG4105DR4 Methyltransferase CH92_05950 ENOG4105P8Q Curli production assembly transport component CsgG CH92_05980 ENOG4105CV8 reductase CH92_05985 ENOG4107JEE Short-chain dehydrogenase reductase Sdr CH92_06015 ENOG4105D8V Glucose sorbosone dehydrogenase CH92_06020 ENOG4105DZG Dehydrogenase CH92_06025 ENOG4105QNR S1 RNA binding domain protein CH92_06045 ENOG4108QV3 biosynthesis protein CH92_06050 ENOG4105C6Y Udp-glucose 6-dehydrogenase CH92_06070 ENOG4105C30 Nad-dependent epimerase dehydratase CH92_06095 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family CH92_06165 ENOG4107U9T Pfam:Ribonuclease_BN CH92_06190 ENOG4108Z4U Ferredoxin CH92_06195 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CH92_06205 ENOG4107TH8 cina domain protein CH92_06215 ENOG4105Y3E Modulates RecA activity (By similarity) CH92_06235 ENOG4106IUH DTW domain containing protein CH92_06240 ENOG4108Q5Y Membrane CH92_06250 ENOG4105DUM transcriptional regulator, lysR family CH92_06255 ENOG4105DP0 ferredoxin-NADP reductase CH92_06260 ENOG4105K5B UPF0225 protein CH92_06270 ENOG4105CDV Ompa motb domain protein CH92_06280 ENOG4105DVT helicase CH92_06295 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CH92_06305 ENOG4108XTF Outer Membrane Lipoprotein CH92_06310 ENOG4105D65 subunit l CH92_06315 ENOG4108ZE9 Monovalent cation H antiporter subunit C CH92_06320 ENOG4107R4Z monovalent cation h antiporter subunit d CH92_06330 ENOG4105W4C monovalent cation H antiporter subunit F CH92_06335 ENOG4105KJM monovalent cation h antiporter subunit g CH92_06340 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CH92_06345 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH92_06350 ENOG4105CE9 30S ribosomal protein S2 CH92_06355 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CH92_06360 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CH92_06365 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CH92_06370 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CH92_06375 ENOG4105KNE Phosphatidate cytidylyltransferase CH92_06380 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CH92_06385 ENOG4105DZP Membrane-associated zinc metalloprotease CH92_06390 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CH92_06395 ENOG4105X4K outer membrane chaperone skp CH92_06405 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CH92_06410 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH92_06415 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH92_06420 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CH92_06425 ENOG4105C0B DNA polymerase III (alpha subunit) CH92_06430 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CH92_06435 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CH92_06440 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CH92_06445 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CH92_06450 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CH92_06455 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CH92_06475 ENOG4105CC0 LysR family Transcriptional regulator CH92_06485 ENOG4105C4W S-formylglutathione hydrolase CH92_06490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH92_06495 ENOG41082YX Transcriptional regulator, arsr family CH92_06500 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CH92_06505 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CH92_06510 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CH92_06515 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CH92_06525 ENOG4108K5P (LipO)protein CH92_06530 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH92_06560 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH92_06570 ENOG41068KF Universal stress protein CH92_06575 ENOG4105N1F Hnh endonuclease CH92_06585 ENOG4108594 Permease of the drug metabolite transporter CH92_06595 ENOG4105C8Q Methyl-accepting chemotaxis CH92_06600 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CH92_06625 ENOG4105BZS acriflavin resistance protein CH92_06630 ENOG4105J7D transcriptional regulator CH92_06635 ENOG4108K3A Glutathione S-transferase CH92_06655 ENOG4105JAB phenazine biosynthesis protein, phzf family CH92_06660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH92_06665 ENOG4105C58 cytochrome c oxidase accessory protein ccog CH92_06680 ENOG41067MG lrgb family CH92_06685 ENOG4105EBM Alpha Beta Hydrolase Fold protein CH92_06690 ENOG4105CS1 NAD(P)H quinone oxidoreductase CH92_06700 ENOG4105C0D helicase CH92_06705 ENOG4108JA2 transcriptioN-repair coupling factor CH92_06720 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH92_06725 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH92_06735 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH92_06745 ENOG4105CJ2 (LipO)protein CH92_06755 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CH92_06760 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CH92_06775 ENOG4105D60 lipoprotein releasing system transmembrane protein CH92_06780 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CH92_06785 ENOG4105D60 lipoprotein releasing system transmembrane protein CH92_06795 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CH92_06810 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CH92_06815 ENOG4105W49 UPF0434 protein CH92_06820 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CH92_06825 ENOG4105KJF protein tyrosine phosphatase CH92_06830 ENOG4105D4A Cell wall formation (By similarity) CH92_06845 ENOG4105C03 ribonuclease CH92_06850 ENOG4105EI2 Pseudouridine synthase CH92_06855 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CH92_06860 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CH92_06865 ENOG4108UHJ MAF-like protein CH92_06870 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CH92_06875 ENOG4105VGS 50s ribosomal protein l32 CH92_06880 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CH92_06885 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CH92_06890 ENOG4105CHR reductase CH92_06895 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CH92_06900 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH92_06910 ENOG4105HHA aminodeoxychorismate lyase CH92_06915 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CH92_06920 ENOG4107QRG dna polymerase iii CH92_06930 ENOG4105F8V Hydrolase, tatD family CH92_06935 ENOG4105C85 amino acid CH92_06940 ENOG4105C9B Cysteine desulfurase CH92_06965 ENOG4105DHI Methyltransferase CH92_06970 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CH92_06975 ENOG4105CUZ uba thif-type nad fad binding protein CH92_06980 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CH92_06985 ENOG4105C9B Cysteine desulfurase CH92_06990 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) CH92_06995 ENOG4105KUZ arsenate reductase CH92_07015 ENOG4105CHM Aminotransferase CH92_07030 ENOG4108V3E phosphoribosylglycinamide formyltransferase CH92_07035 ENOG4105CXB phosphoribosylaminoimidazole synthetase CH92_07045 ENOG4105C02 permease CH92_07060 ENOG4105CS1 NAD(P)H quinone oxidoreductase CH92_07065 ENOG4105K89 arsenate reductase CH92_07070 ENOG4107S2Z UPF0761 membrane protein CH92_07075 ENOG4105K63 Thioredoxin CH92_07090 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CH92_07095 ENOG4105J5J Outer membrane porin CH92_07105 ENOG41069P5 Protein slyX homolog CH92_07110 ENOG4105VEQ Cold shock protein CH92_07120 ENOG4105C9M aspartyl-trna synthetase CH92_07130 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CH92_07135 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CH92_07140 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CH92_07145 ENOG4107YD3 Thioesterase CH92_07150 ENOG4105E02 MotA TolQ exbB proton channel CH92_07155 ENOG4105M8F Biopolymer transport protein exbD tolR CH92_07165 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CH92_07170 ENOG4105KCK Peptidoglycan-associated lipoprotein CH92_07175 ENOG4105UFD tol-pal system protein YbgF CH92_07185 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CH92_07195 ENOG4105CYC Transferase CH92_07205 ENOG4105ERG peptidase m48, ste24p CH92_07210 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CH92_07220 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH92_07230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH92_07240 ENOG4105C8V SAICAR synthetase CH92_07250 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CH92_07270 ENOG4105C5I Dehydrogenase CH92_07275 ENOG4108ZX5 transcriptional regulator CH92_07295 ENOG4107T32 3-phytase (EC 3.1.3.8) CH92_07300 ENOG4105E02 MotA TolQ exbB proton channel CH92_07305 ENOG4105M8F Biopolymer transport protein exbD tolR CH92_07345 ENOG410689M (LipO)protein CH92_07360 ENOG4105CGY Dna recombination protein CH92_07365 ENOG4105BZU Histidine kinase CH92_07390 ENOG4107W52 maltose operon periplasmic protein CH92_07395 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CH92_07405 ENOG4105DDW LysR family Transcriptional regulator CH92_07410 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta CH92_07415 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha CH92_07420 ENOG4105D6Z AFG1 family ATPase CH92_07425 ENOG4105RK9 auxin efflux carrier CH92_07430 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CH92_07435 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CH92_07445 ENOG4107T9C Alpha amylase catalytic region CH92_07450 ENOG4107FKK extracellular solute-binding protein family 1 CH92_07455 ENOG4105D56 permease protein CH92_07460 ENOG4105EG2 ABC transporter, permease CH92_07465 ENOG41061ZR Transcriptional regulator CH92_07480 ENOG4105CG3 alpha amylase, catalytic region CH92_07495 ENOG4105C09 Bile acid CH92_07500 ENOG4105DH7 May be involved in recombination (By similarity) CH92_07515 ENOG4108V1T peptidylprolyl cis-trans isomerase CH92_07530 ENOG4105CGF Aromatic amino acid aminotransferase CH92_07535 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CH92_07550 ENOG4105HEI LysR family (Transcriptional regulator CH92_07555 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CH92_07600 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CH92_07620 ENOG4105D94 Major Facilitator Superfamily CH92_07625 ENOG4105GPY SprT protein CH92_07635 ENOG41069YE inner membrane protein yohC CH92_07645 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CH92_07650 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH92_07655 ENOG4108R3E Dna-3-methyladenine glycosylase i CH92_07660 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CH92_07665 ENOG4105K4H Nlp p60 protein CH92_07670 ENOG4105K4H Nlp p60 protein CH92_07680 ENOG4105DN9 Na H antiporter CH92_07695 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) CH92_07705 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CH92_07710 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CH92_07715 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase CH92_07720 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CH92_07725 ENOG4105EFT decarboxylase CH92_07730 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CH92_07735 ENOG4108YZT Adenosylcobinamide kinase CH92_07740 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CH92_07745 ENOG4108TGR phosphatase CH92_07750 ENOG4105GN9 Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CH92_07755 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CH92_07760 ENOG4105E0C molybdate abc transporter CH92_07765 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CH92_07770 ENOG4105F4R Transcriptional regulator mode CH92_07780 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CH92_07785 ENOG4105KHC sulfurtransferase CH92_07795 ENOG4105VNG YcgL domain-containing protein CH92_07800 ENOG4108ZZ3 UPF0260 protein CH92_07810 ENOG4105C5W Aldolase CH92_07815 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CH92_07820 ENOG4105CFH Aspartokinase CH92_07825 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CH92_07850 ENOG4105CJW magnesium transporter CH92_07860 ENOG4107QSA Oxaloacetate decarboxylase CH92_07865 ENOG4105D9Q decarboxylase (Beta subunit) CH92_07890 ENOG4106825 Type iv pilus assembly CH92_07910 ENOG4107R88 Chemotaxis protein (CheV) CH92_07915 ENOG4105BZU Histidine kinase CH92_07920 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CH92_07925 ENOG4108ZC9 flagellar basal-body rod protein flgc CH92_07930 ENOG4105W00 Flagellar hook capping protein CH92_07935 ENOG4105BZE flagellar hook protein, FlgE CH92_07940 ENOG4108KPB Flagellar basal-body rod protein FlgF CH92_07945 ENOG4105CGA flagellar basal-body rod protein FlgG CH92_07950 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) CH92_07955 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) CH92_07960 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CH92_07965 ENOG4105E1Q flagellar hook-associated protein CH92_07970 ENOG4105I03 Flagellin CH92_07975 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CH92_08000 ENOG4105BZU Histidine kinase CH92_08005 ENOG4105CN1 protease CH92_08010 ENOG4105DFM M18 family aminopeptidase CH92_08015 ENOG4105D3G Pseudouridine synthase CH92_08020 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CH92_08025 ENOG4107QMS site-determining protein CH92_08030 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CH92_08035 ENOG4105D1S lipid A biosynthesis CH92_08040 ENOG4105EUB pirin domain protein CH92_08045 ENOG410903C (LipO)protein CH92_08060 ENOG41062QD Membrane CH92_08065 ENOG4107QN1 sodium solute CH92_08095 ENOG4106851 UPF0270 protein CH92_08100 ENOG4105BZU Histidine kinase CH92_08105 ENOG4105DER m42 family CH92_08110 ENOG4107RRY Cyanophycin synthetase CH92_08115 ENOG4105CAQ asparagine synthetase CH92_08130 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CH92_08135 ENOG4105CSR polyphosphate kinase 2 CH92_08140 ENOG4105CHU acetyl-coa acetyltransferase CH92_08145 ENOG4105C9Q fumarate hydratase class II CH92_08155 ENOG4105M85 Bola protein CH92_08160 ENOG4105C72 UPF0176 protein CH92_08175 ENOG4105C8Q Methyl-accepting chemotaxis CH92_08190 ENOG4108YZN class I peptide chain release factor CH92_08205 ENOG4108M9J MaoC like domain protein CH92_08210 ENOG4105C1G acyl-Coa dehydrogenase CH92_08215 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase CH92_08230 ENOG4105CI0 Citrate lyase CH92_08235 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_08245 ENOG4107QPN acyl-Coa dehydrogenase CH92_08250 ENOG4105DA5 (ABC) transporter CH92_08255 ENOG4105E3A (ABC) transporter CH92_08280 ENOG4105I93 response regulator CH92_08290 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CH92_08295 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH92_08315 ENOG4105C7K acetolactate synthase CH92_08320 ENOG4107RSM transcriptional regulator CH92_08325 ENOG4105CPT Alpha beta hydrolase CH92_08330 ENOG4105DC8 reductase CH92_08335 ENOG4105C0B DNA polymerase III (alpha subunit) CH92_08340 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA CH92_08355 ENOG4105D3R alkyl hydroperoxide reductase CH92_08360 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CH92_08365 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH92_08380 ENOG4105CIH Imidazole acetol-phosphate transaminase CH92_08385 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CH92_08390 ENOG4105CAT Cytidine monophosphate kinase CH92_08395 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CH92_08405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH92_08410 ENOG4108RXX maleylacetoacetate isomerase CH92_08415 ENOG4105EUJ GTP cyclohydrolase i CH92_08435 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CH92_08450 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CH92_08460 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CH92_08465 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CH92_08470 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) CH92_08490 ENOG4105D03 DNA-3-methyladenine glycosylase II CH92_08495 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CH92_08505 ENOG4105EJC lysr family transcriptional regulator CH92_08515 ENOG4107QI1 Mate efflux family protein CH92_08520 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) CH92_08525 ENOG4107QMP dna polymerase iii subunits gamma and tau CH92_08530 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CH92_08535 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CH92_08550 ENOG4105C8U phosphate abc transporter CH92_08565 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CH92_08570 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CH92_08575 ENOG4105D4P Coproporphyrinogen iii oxidase CH92_08580 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CH92_08605 ENOG4105C58 cytochrome c oxidase accessory protein ccog CH92_08610 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) CH92_08625 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i CH92_08640 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i CH92_08650 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CH92_08655 ENOG4107QM5 aconitate hydratase CH92_08660 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CH92_08675 ENOG4105BZ9 Cytochrome C oxidase, subunit I CH92_08680 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CH92_08695 ENOG4105EYW Ion transport protein CH92_08700 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CH92_08710 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) CH92_08715 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CH92_08740 ENOG4105DTS flagellar hook-associated CH92_08745 ENOG4105MQ3 flagellar protein FliS CH92_08765 ENOG4105BZN citrate synthase CH92_08770 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CH92_08775 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CH92_08780 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CH92_08785 ENOG4105E33 succinate dehydrogenase CH92_08790 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CH92_08795 ENOG4105C7S Dehydrogenase CH92_08800 ENOG4107QN2 dihydrolipoyl dehydrogenase CH92_08805 ENOG4105CMV Succinyl-CoA synthetase subunit beta CH92_08810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CH92_08815 ENOG4105CWM branched-chain amino acid transport system II carrier protein CH92_08840 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CH92_08855 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CH92_08865 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CH92_08870 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CH92_08885 ENOG4105KA0 thioesterase Superfamily protein CH92_08905 ENOG4105IPI Membrane CH92_08915 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CH92_08920 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) CH92_08930 ENOG4107XC4 flavin reductase domain protein, FMN-binding CH92_08935 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CH92_08945 ENOG4105F8C transglutaminase domain-containing protein CH92_08960 ENOG4105F8V Hydrolase, tatD family CH92_08965 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CH92_08975 ENOG4107IFA Lipase (EC 3.1.1.3) CH92_08985 ENOG4108RRZ Transcription elongation factor GreB CH92_08990 ENOG4105CV6 ABC transporter, permease CH92_08995 ENOG4108I0Y (ABC) transporter CH92_09000 ENOG4108UJV acyl-CoA thioesterase i CH92_09010 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CH92_09025 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH92_09030 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CH92_09035 ENOG4107R11 Transcriptional regulator CH92_09045 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein CH92_09050 ENOG4105CRQ synthase (Component I) CH92_09070 ENOG4105DRR Transcriptional regulator, GntR family CH92_09075 ENOG4105CR4 methylisocitrate lyase CH92_09080 ENOG4105BZN citrate synthase CH92_09085 ENOG4108I0Z Aconitate hydratase CH92_09090 ENOG4105C7F AcnD-accessory protein PrpF CH92_09095 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CH92_09105 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CH92_09130 ENOG4105CDV Ompa motb domain protein CH92_09135 ENOG4107RET Isocitrate lyase CH92_09150 ENOG41082BV acetyltransferase CH92_09155 ENOG4105EZE Cupin 4 family protein CH92_09160 ENOG4107QTF adenylosuccinate lyase CH92_09165 ENOG41075W9 High frequency lysogenization protein HflD homolog CH92_09170 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CH92_09180 ENOG4105E9K Isocitrate dehydrogenase CH92_09190 ENOG4105VEQ Cold shock protein CH92_09195 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CH92_09200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH92_09205 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CH92_09210 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate CH92_09215 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CH92_09220 ENOG4105C3M thioredoxin reductase CH92_09225 ENOG4105CNU cell division protein FtsK CH92_09230 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CH92_09235 ENOG4105D1H recombination factor protein RarA CH92_09240 ENOG4105WMR Protein CrcB homolog CH92_09245 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CH92_09250 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH92_09255 ENOG4105CHF Glutathione S-transferase CH92_09260 ENOG4107QYG anthranilate phosphoribosyltransferase CH92_09265 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CH92_09270 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH92_09275 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH92_09280 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CH92_09285 ENOG4108MN8 Membrane CH92_09295 ENOG4105FDR Membrane CH92_09300 ENOG4105F9N Major Facilitator Superfamily CH92_09320 ENOG4107SFQ iron-sulfur binding CH92_09355 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CH92_09365 ENOG4105CCU oxidase (Subunit III) CH92_09380 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CH92_09385 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CH92_09390 ENOG4105E9S glutaredoxin 2 CH92_09395 ENOG4107QS8 (LipO)protein CH92_09410 ENOG4108IEG Formate dehydrogenase Alpha subunit CH92_09420 ENOG4108VP3 Lysine exporter protein (LysE YggA) CH92_09430 ENOG4105NCT RNA Polymerase CH92_09440 ENOG4105E18 UPF0276 protein CH92_09455 ENOG4107VXZ Hydrolase CH92_09480 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CH92_09485 ENOG4105BZN citrate synthase CH92_09515 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CH92_09520 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CH92_09535 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CH92_09545 ENOG4108PVQ transcriptional regulator CH92_09550 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CH92_09575 ENOG4105C94 Transporter CH92_09580 ENOG4105F1S paraquat-inducible protein a CH92_09585 ENOG4105F1S paraquat-inducible protein a CH92_09590 ENOG4105DY2 Paraquat-inducible protein b CH92_09615 ENOG4108KKZ (LipO)protein CH92_09625 ENOG4105DFI Membrane CH92_09630 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CH92_09635 ENOG4105C26 Dehydrogenase CH92_09645 ENOG4105CHB tonB-dependent Receptor CH92_09660 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CH92_09685 ENOG4105GQR Chaperone CH92_09700 ENOG4108VYJ response regulator receiver protein CH92_09710 ENOG4105CBS Chea signal transduction histidine kinase CH92_09715 ENOG4105C8Q Methyl-accepting chemotaxis CH92_09720 ENOG4108V3W Chemotaxis protein, CheW CH92_09725 ENOG4105BZU Histidine kinase CH92_09730 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CH92_09735 ENOG4105WH1 Two component transcriptional regulator luxr family CH92_09740 ENOG4105C0H protease CH92_09750 ENOG4105XDF Protein of unknown function (DUF1272) CH92_09755 ENOG4105BZU Histidine kinase CH92_09790 ENOG4105CHU acetyl-coa acetyltransferase CH92_09795 ENOG4107R88 Chemotaxis protein (CheV) CH92_09805 ENOG4105CQ2 DNA polymerase CH92_09830 ENOG4105BZU Histidine kinase CH92_09840 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CH92_09845 ENOG4105FUA antagonist CH92_09850 ENOG4107MMM Anti-sigma-factor antagonist CH92_09855 ENOG4105BZU Histidine kinase CH92_09860 ENOG4106MWK domain protein CH92_09875 ENOG4105D9P serine threonine protein kinase CH92_09880 ENOG4105TMB Formate nitrite transporter CH92_09890 ENOG4107QZF nitrite reductase NADPH large subunit CH92_09895 ENOG4107RGM aldo keto reductase CH92_09905 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CH92_09955 ENOG4105DFD Na H antiporter CH92_09960 ENOG4105CIF Ornithine Cyclodeaminase CH92_09975 ENOG4105C2I pirin domain protein CH92_09980 ENOG4105CR8 Transcriptional regulator CH92_09990 ENOG4105E5M Multidrug resistance protein D CH92_10005 ENOG4105EU0 Major facilitator Superfamily CH92_10010 ENOG4105R1U AraC Family Transcriptional Regulator CH92_10020 ENOG4105CF7 AraC family transcriptional regulator CH92_10025 ENOG4105CHR reductase CH92_10035 ENOG4105EG6 Saccharopine dehydrogenase CH92_10040 ENOG4108XFH Transcriptional regulator CH92_10045 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CH92_10060 ENOG4108NVR Methyl-accepting chemotaxis CH92_10065 ENOG4105CY0 Metallo-Beta-Lactamase CH92_10075 ENOG4105CDA abc transporter atp-binding protein CH92_10080 ENOG4105E5Q amino acid AbC transporter CH92_10085 ENOG4105EAB amino acid AbC transporter CH92_10115 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH92_10120 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CH92_10125 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_10140 ENOG4105JSC dimethylmenaquinone methyltransferase CH92_10145 ENOG4106NZI LysR family Transcriptional regulator CH92_10150 ENOG4107RGH Aldehyde dehydrogenase CH92_10165 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH92_10170 ENOG4105Q26 Siderophore-interacting protein CH92_10185 ENOG4108W2Y isochorismatase CH92_10210 ENOG4105SB3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CH92_10225 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CH92_10230 ENOG4108K3A Glutathione S-transferase CH92_10255 ENOG4105F1J Homogentisate 1,2-dioxygenase CH92_10280 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CH92_10290 ENOG4105C8Q Methyl-accepting chemotaxis CH92_10295 ENOG4105CRW Short chain fatty acid transporter CH92_10300 ENOG4105CHU acetyl-coa acetyltransferase CH92_10310 ENOG4105D6N CoA-transferase, subunit a CH92_10315 ENOG4108M0I Transcriptional regulator CH92_10325 ENOG4105BZU Histidine kinase CH92_10330 ENOG4107HP6 Transcriptional regulator CH92_10345 ENOG4105CHU acetyl-coa acetyltransferase CH92_10350 ENOG4105F2Z 3-oxoadipate enol-lactonase CH92_10365 ENOG4105EEQ Na H antiporter CH92_10390 ENOG4108M0I Transcriptional regulator CH92_10410 ENOG4108UQ8 endoribonuclease L-psp CH92_10415 ENOG4105ETE Transcriptional regulator (LacI family CH92_10430 ENOG4105EAA nucleoside CH92_10445 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH92_10460 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CH92_10465 ENOG4105F6U Short-chain dehydrogenase reductase Sdr CH92_10475 ENOG4105JQN Transcriptional regulator CH92_10485 ENOG4105BZU Histidine kinase CH92_10490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CH92_10495 ENOG4108ZXC Two component transcriptional regulator, luxr family CH92_10500 ENOG41064T2 transcriptional regulator, lysR family CH92_10510 ENOG4107SFI Major Facilitator superfamily CH92_10515 ENOG4105CHJ isochorismatase hydrolase CH92_10530 ENOG4105CPN adenine deaminase CH92_10535 ENOG4108ZFD Antibiotic biosynthesis monooxygenase CH92_10550 ENOG4105CHJ isochorismatase hydrolase CH92_10565 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH92_10580 ENOG4105CBN LysR family transcriptional regulator CH92_10590 ENOG4105DTD Dehydrogenase CH92_10600 ENOG4108JUA Transcriptional regulator CH92_10605 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_10615 ENOG4105CH5 extracellular solute-binding protein, family 7 CH92_10625 ENOG4108Z6Z Transcriptional regulator CH92_10640 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CH92_10655 ENOG4108IPT Naphthoate synthase CH92_10660 ENOG4107QX3 carboxylase CH92_10665 ENOG4105C1G acyl-Coa dehydrogenase CH92_10670 ENOG4105CEY Amp-dependent synthetase and ligase CH92_10680 ENOG4105EPF Outer membrane porin CH92_10685 ENOG4105C0Z ABC transporter CH92_10690 ENOG4108IV0 ABC, transporter CH92_10700 ENOG4105C32 Amino acid ABC transporter (Permease) CH92_10705 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CH92_10710 ENOG4105E39 Enoyl-CoA hydratase CH92_10720 ENOG4108ZX5 transcriptional regulator CH92_10730 ENOG4105CHU acetyl-coa acetyltransferase CH92_10735 ENOG4105C1G acyl-Coa dehydrogenase CH92_10740 ENOG4105C5I Dehydrogenase CH92_10750 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CH92_10755 ENOG4105CEY Amp-dependent synthetase and ligase CH92_10760 ENOG4105C1G acyl-Coa dehydrogenase CH92_10765 ENOG4105E39 Enoyl-CoA hydratase CH92_10770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CH92_10775 ENOG4105C26 Dehydrogenase CH92_10795 ENOG4105EMU Dehydrogenase CH92_10800 ENOG4105K70 DNA-binding protein CH92_10840 ENOG4105E5J UV damage endonuclease CH92_10845 ENOG41088T4 Helicase IV CH92_10850 ENOG4108TGY Glutathione S-transferase CH92_10855 ENOG4105ETT transcriptional Regulator, LysR family CH92_10865 ENOG4105KPY Small multidrug resistance protein CH92_10870 ENOG4107XBN GntR Family Transcriptional Regulator CH92_10880 ENOG4105E5Q amino acid AbC transporter CH92_10885 ENOG4105E5Q amino acid AbC transporter CH92_10890 ENOG4105CDA abc transporter atp-binding protein CH92_10895 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CH92_10900 ENOG4105CVP deoxyribo-dipyrimidine photolyase CH92_10905 ENOG4107SEY Conserved Protein CH92_10910 ENOG4105ECP epimerase CH92_10915 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CH92_10920 ENOG4105BZU Histidine kinase CH92_10925 ENOG4105BZU Histidine kinase CH92_10930 ENOG4108XDN Transcriptional regulator CH92_10935 ENOG4108JQM Insulinase (Peptidase family M16) CH92_10940 ENOG4105BZU Histidine kinase CH92_10975 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) CH92_10980 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) CH92_10985 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d CH92_10990 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CH92_11005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH92_11010 ENOG4105KK4 UPF0060 membrane protein CH92_11015 ENOG4105CAU Arsenical resistance protein, ArsH CH92_11020 ENOG41082YX Transcriptional regulator, arsr family CH92_11025 ENOG4105D6J arsenicaL-resistance protein CH92_11035 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CH92_11090 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_11100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_11110 ENOG4105E9Z Nad-dependent epimerase dehydratase CH92_11115 ENOG4105DIA mandelate racemase muconate lactonizing CH92_11120 ENOG4108KB2 LysR family Transcriptional regulator CH92_11125 ENOG4105DIA mandelate racemase muconate lactonizing CH92_11150 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CH92_11155 ENOG4105C26 Dehydrogenase CH92_11165 ENOG4105CTX dehydratase CH92_11170 ENOG4105CQB FAD linked oxidase domain protein CH92_11175 ENOG4105C5I Dehydrogenase CH92_11185 ENOG4105DNP FAD linked oxidase domain protein CH92_11190 ENOG41090KI Outer membrane porin CH92_11200 ENOG4105F2V VRR-NUC domain-containing protein CH92_11205 ENOG4105D4P Coproporphyrinogen iii oxidase CH92_11210 ENOG4108NVR Methyl-accepting chemotaxis CH92_11215 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CH92_11220 ENOG4105HUJ glyoxalase bleomycin resistance protein dioxygenase CH92_11225 ENOG4105DC8 reductase CH92_11230 ENOG4106E5D Protein of unknown function (DUF461) CH92_11235 ENOG4105VG5 Membrane CH92_11240 ENOG4105JP4 Inner membrane protein yidG CH92_11245 ENOG4105C5W Aldolase CH92_11265 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CH92_11270 ENOG4105ZQC membrane protein AaeX CH92_11285 ENOG4105CR8 Transcriptional regulator CH92_11295 ENOG4105DQE DNA ligase CH92_11310 ENOG4108N8X transition metal ion binding CH92_11315 ENOG4105EGS Mechanosensitive ion channel CH92_11320 ENOG4105CEV competence damage-inducible protein CH92_11325 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CH92_11330 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CH92_11335 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CH92_11365 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CH92_11370 ENOG4105EJC lysr family transcriptional regulator CH92_11385 ENOG4105X23 Endonuclease Exonuclease phosphatase CH92_11390 ENOG4105DZQ phospholipase D Transphosphatidylase CH92_11395 ENOG4107UXM Membrane CH92_11400 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CH92_11405 ENOG4105CG3 alpha amylase, catalytic region CH92_11410 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) CH92_11425 ENOG4108MG3 formate dehydrogenase CH92_11430 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH92_11435 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH92_11440 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH92_11445 ENOG4105DQE DNA ligase CH92_11450 ENOG4105FDF Could be involved in DNA repair (By similarity) CH92_11460 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CH92_11485 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_11490 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH92_11495 ENOG4105BZS acriflavin resistance protein CH92_11515 ENOG4105CJR Integral membrane protein (MviN CH92_11580 ENOG4108KEZ Dehydrogenase CH92_11585 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_11595 ENOG41062YB Trap dicarboxylate transporter, dctp subunit CH92_11600 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CH92_11605 ENOG4105C26 Dehydrogenase CH92_11610 ENOG4107RSM transcriptional regulator CH92_11615 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CH92_11650 ENOG410620I Diguanylate cyclase CH92_11670 ENOG4105BZU Histidine kinase CH92_11675 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CH92_11695 ENOG4105CHR reductase CH92_11700 ENOG4105ECQ AraC Family Transcriptional Regulator CH92_11735 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CH92_11750 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CH92_11760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH92_11765 ENOG4108IJ9 (ABC) transporter CH92_11770 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CH92_11775 ENOG4105C8N cysteinyl-tRNA synthetase CH92_11780 ENOG4105CX6 glutaminyL-tRNA synthetase CH92_11785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH92_11790 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CH92_11795 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase CH92_11815 ENOG4107QIJ Aconitate hydratase 2 CH92_11820 ENOG4105C5H ABC transporter CH92_11825 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CH92_11840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CH92_11845 ENOG4105C8Q Methyl-accepting chemotaxis CH92_11865 ENOG4107VMU Membrane CH92_11880 ENOG4105BZU Histidine kinase CH92_11885 ENOG4108WZ2 response regulator CH92_11890 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) CH92_11895 ENOG4105C3R Methionine synthase CH92_11910 ENOG4108Q5Y Membrane CH92_11925 ENOG4106UW1 Major Facilitator superfamily CH92_11930 ENOG4105EVD ribosomal RNA large subunit methyltransferase N CH92_11935 ENOG4105D9P serine threonine protein kinase CH92_11970 ENOG4105ERU peptidase CH92_11990 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CH92_12015 ENOG4105E09 nadh pyrophosphatase CH92_12025 ENOG4105E39 Enoyl-CoA hydratase CH92_12030 ENOG4105CXN decarboxylase CH92_12035 ENOG4107RZZ dna polymerase iii epsilon subunit CH92_12040 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CH92_12055 ENOG4105E9H Lytic Murein transglycosylase CH92_12065 ENOG4105E43 Extracellular solute-binding protein, family 5 CH92_12075 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CH92_12080 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CH92_12085 ENOG4108JQ5 ABC transporter CH92_12090 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CH92_12095 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CH92_12100 ENOG4105K70 DNA-binding protein CH92_12105 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CH92_12110 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CH92_12115 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CH92_12120 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CH92_12125 ENOG4105MGM doxx family CH92_12135 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_12145 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_12155 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CH92_12160 ENOG4105BZG amino acid carrier protein CH92_12165 ENOG4105MA0 exported protein CH92_12170 ENOG4105CFU surface antigen CH92_12180 ENOG4105CGK Exodeoxyribonuclease III CH92_12185 ENOG4105CVA phosphate CH92_12205 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CH92_12220 ENOG4105DEI Mannitol dehydrogenase CH92_12225 ENOG4105CMG Carbohydrate kinase CH92_12240 ENOG4105ETE Transcriptional regulator (LacI family CH92_12245 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_12250 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_12255 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CH92_12260 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CH92_12265 ENOG4105D6Z AFG1 family ATPase CH92_12280 ENOG4105D3Y Na H antiporter CH92_12285 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CH92_12325 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CH92_12330 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CH92_12335 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CH92_12340 ENOG4105UBK short-chain dehydrogenase reductase CH92_12345 ENOG4105BZU Histidine kinase CH92_12360 ENOG4105FE9 pseudouridine synthase CH92_12365 ENOG4108UHU Aldolase CH92_12370 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) CH92_12375 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CH92_12380 ENOG4106KNT transcriptional regulator CH92_12390 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CH92_12400 ENOG4105I1K ABC transporter CH92_12405 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CH92_12410 ENOG4108JP0 extracellular solute-binding protein family 1 CH92_12415 ENOG4107QKS N-acylglucosamine 2-epimerase CH92_12420 ENOG4105E0F Histidine kinase CH92_12425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CH92_12435 ENOG4105C01 Dihydroxy-acid dehydratase CH92_12440 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH92_12445 ENOG4108Z5K methylglyoxal synthase CH92_12450 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CH92_12460 ENOG4105C31 Tryptophanyl-tRNA synthetase CH92_12465 ENOG4107RTD sua5 ycio yrdc ywlc family protein CH92_12470 ENOG4105DB7 PHP domain protein CH92_12475 ENOG4107835 probably involved in intracellular septation (By similarity) CH92_12480 ENOG4105K9H YciI-like protein CH92_12490 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH92_12500 ENOG410804D Sensor Signal Transduction Histidine Kinase CH92_12505 ENOG41069NU Nitroreductase CH92_12510 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CH92_12515 ENOG4108Z6B deaminase CH92_12520 ENOG4105CKW Inner membrane protein yedI CH92_12530 ENOG4105F8J Adenylate Guanylate cyclase CH92_12535 ENOG4105E7U AraC family transcriptional regulator CH92_12550 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_12560 ENOG4105CZJ Aldehyde dehydrogenase CH92_12580 ENOG4105D78 K07001 NTE family protein CH92_12590 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CH92_12595 ENOG4105C9U ATP-dependent DNA helicase RecQ CH92_12605 ENOG4105WD1 Membrane CH92_12620 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) CH92_12635 ENOG4105C6T cysteine synthase CH92_12665 ENOG4105E7A Glutamine amidotransferase CH92_12675 ENOG41081QV Universal stress protein CH92_12685 ENOG4105C5H ABC transporter CH92_12690 ENOG4107SC1 transglycosylase CH92_12695 ENOG4105QVC MOSC domain-containing protein CH92_12705 ENOG4107TE5 Lipid kinase CH92_12710 ENOG4105D3Q Sugar transferase CH92_12715 ENOG4107ZF2 Phosphatase CH92_12720 ENOG4105D75 Capsular exopolysaccharide family CH92_12745 ENOG4105C0K Gdp-mannose 4,6-dehydratase CH92_12755 ENOG4108DMA Nad-dependent epimerase dehydratase CH92_12760 ENOG4105DAY polysaccharide export protein CH92_12770 ENOG4105RD8 TRAP dicarboxylate transporter CH92_12780 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_12785 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase CH92_12825 ENOG4105W5Q DNA repair protein (RadC CH92_12860 ENOG4107QRT dEAD DEAH box helicase CH92_12885 ENOG4108QVN serine threonine protein kinase CH92_12905 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CH92_12910 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CH92_12915 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CH92_12920 ENOG41082NX 50s ribosomal protein l35 CH92_12925 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CH92_12930 ENOG4105C22 threonyL-tRNA synthetase CH92_12940 ENOG4105CJP fad dependent oxidoreductase CH92_12965 ENOG4105CVM Molybdenum cofactor synthesis domain protein CH92_12970 ENOG4108RIR Molybdenum cofactor biosynthesis protein CH92_12995 ENOG4105EPF Outer membrane porin CH92_13025 ENOG41090ED Protein with unknown function (DUF469) CH92_13030 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CH92_13035 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CH92_13040 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) CH92_13045 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CH92_13060 ENOG4105C7I Dehydrogenase CH92_13065 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CH92_13095 ENOG4105I5W Transporter CH92_13115 ENOG4105D7T ABC transporter CH92_13120 ENOG4107SDU Methyl-accepting chemotaxis CH92_13140 ENOG4105D9P serine threonine protein kinase CH92_13150 ENOG4108IFG nitrite reductase, (NAD(P)H) CH92_13155 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CH92_13165 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH92_13170 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CH92_13175 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH92_13185 ENOG4105GKE subunit e CH92_13190 ENOG4107QIZ NADH dehydrogenase CH92_13195 ENOG4108IEH NADH dehydrogenase subunit g CH92_13200 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CH92_13205 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH92_13210 ENOG4107UFS subunit j CH92_13215 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH92_13220 ENOG4105D65 subunit l CH92_13225 ENOG4105C8S subunit m CH92_13230 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH92_13245 ENOG4105CD8 aminopeptidase N CH92_13265 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CH92_13270 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CH92_13305 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH92_13315 ENOG4108ZX5 transcriptional regulator CH92_13330 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CH92_13335 ENOG4105C4M (Ubiquinol oxidase) subunit I CH92_13345 ENOG4106I3Z CH92_13350 ENOG4105GVR general secretion pathway protein D CH92_13355 ENOG4105C28 cystathionine CH92_13360 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CH92_13365 ENOG4105E96 Colicin v production protein CH92_13370 ENOG41063M6 Cell Division Protein CH92_13375 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CH92_13380 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CH92_13385 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CH92_13390 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CH92_13400 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH92_13405 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CH92_13415 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CH92_13420 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CH92_13425 ENOG4108MP6 LysR family Transcriptional regulator CH92_13435 ENOG4105BZU Histidine kinase CH92_13445 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CH92_13510 ENOG4105CG5 Glycosyl transferase (Group 1 CH92_13525 ENOG4108TJN glycosyl transferase group 1 CH92_13530 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CH92_13555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CH92_13560 ENOG4105EHU Circadian clock protein KaiC CH92_13565 ENOG4105BZU Histidine kinase CH92_13570 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) CH92_13580 ENOG4108R86 Transcriptional regulator CH92_13610 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component CH92_13620 ENOG4105EMU Dehydrogenase CH92_13630 ENOG4108JQ9 ABC transporter CH92_13635 ENOG4105UIB (ABC) transporter CH92_13645 ENOG4108RU0 short-chain dehydrogenase reductase CH92_13675 ENOG4105C26 Dehydrogenase CH92_13680 ENOG4105C94 Transporter CH92_13685 ENOG4108R96 Methyltransferase, YaeB family CH92_13690 ENOG4105CUJ penicillin amidase CH92_13700 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CH92_13710 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) CH92_13730 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CH92_13735 ENOG4106AIJ Cell Division CH92_13755 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH92_13765 ENOG4105CHU acetyl-coa acetyltransferase CH92_13770 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH92_13775 ENOG4105CUG Oligopeptidase b CH92_13795 ENOG4105C8Y Acetylornithine aminotransferase CH92_13805 ENOG4105CPI Metal Dependent Phosphohydrolase CH92_13820 ENOG4105K8Z Phage shock protein CH92_13825 ENOG4105D64 Mechanosensitive ion channel CH92_13830 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CH92_13835 ENOG4105EXU Membrane CH92_13840 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_13845 ENOG4107RSM transcriptional regulator CH92_13850 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CH92_13855 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CH92_13860 ENOG41062MS nucleotidyltransferase substrate binding protein CH92_13875 ENOG4105ESV Glycosyl transferase, family 4 CH92_13890 ENOG4105E2K Glycosyl transferase (Group 1 CH92_13900 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CH92_13915 ENOG4105K64 Glycosyl transferase, family 2 CH92_13920 ENOG4105K64 Glycosyl transferase, family 2 CH92_13925 ENOG4107QQG Dehydrogenase CH92_13930 ENOG4108IJ1 Dehydrogenase CH92_13940 ENOG4105CY0 Metallo-Beta-Lactamase CH92_13945 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CH92_13960 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CH92_13965 ENOG4105C8P )-transporter CH92_13970 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CH92_13985 ENOG4108QDE fad dependent oxidoreductase CH92_14010 ENOG4108U78 Glutathione S-transferase CH92_14020 ENOG4108V06 Glutathione peroxidase CH92_14025 ENOG4105E0X reductase CH92_14030 ENOG4105CHM Aminotransferase CH92_14040 ENOG4105D0M Protease HtpX homolog CH92_14045 ENOG4105FQ6 thiopurine methyltransferase CH92_14050 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_14055 ENOG4105BZU Histidine kinase CH92_14060 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_14070 ENOG4108M1T Cytochrome c-type biogenesis protein CH92_14075 ENOG4105KWW Biogenesis protein CH92_14080 ENOG4107QX9 Thiol disulfide interChange protein CH92_14085 ENOG4105DA4 cytochrome c-type biogenesis protein CH92_14090 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) CH92_14100 ENOG41060IM Heme exporter protein CH92_14110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CH92_14115 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) CH92_14140 ENOG4108V3W Chemotaxis protein, CheW CH92_14150 ENOG4107QJE Chromosome Partitioning Protein CH92_14155 ENOG4105ER2 Ompa motb domain protein CH92_14160 ENOG4105E14 MotA TolQ exbB proton channel CH92_14165 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CH92_14170 ENOG4105CBS Chea signal transduction histidine kinase CH92_14175 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) CH92_14180 ENOG4108VYJ response regulator receiver protein CH92_14185 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH92_14200 ENOG4105FZW flagellar biosynthesis regulator FlhF CH92_14205 ENOG4105D7B Flagellar biosynthesis protein flha CH92_14210 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH92_14215 ENOG4105D00 flagellar biosynthetic protein flhB CH92_14220 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CH92_14225 ENOG4105VS8 Flagellar biosynthetic protein fliq CH92_14230 ENOG4105CN7 Flagellar biosynthetic protein FliP CH92_14235 ENOG4105VTB flagellar biosynthesis protein fliO CH92_14240 ENOG4105DD5 Flagellar motor switch protein CH92_14245 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CH92_14250 ENOG4107ZI8 flagellar basal body-associated protein flil CH92_14265 ENOG4108KXV response regulator CH92_14280 ENOG4108JIR Flagellum-specific ATP synthase CH92_14290 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CH92_14295 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CH92_14300 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CH92_14305 ENOG4105DKK Benzoate CH92_14310 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CH92_14315 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CH92_14330 ENOG4105BZU Histidine kinase CH92_14340 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH92_14360 ENOG4105C10 Electron transfer flavoprotein CH92_14365 ENOG4105BZJ Electron transfer flavoprotein CH92_14370 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CH92_14395 ENOG4105E55 glycerol-3-phosphate acyltransferase CH92_14415 ENOG4108UT2 hemolysin iii CH92_14450 ENOG4105E3B Multicopper oxidase CH92_14470 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) CH92_14475 ENOG4105DJ9 glucan biosynthesis protein CH92_14480 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CH92_14500 ENOG4107T0X DNA ligase CH92_14505 ENOG4107QRT dEAD DEAH box helicase CH92_14540 ENOG4105DXN mazG family CH92_14545 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH92_14550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CH92_14555 ENOG4105C6T cysteine synthase CH92_14560 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CH92_14565 ENOG4105BZU Histidine kinase CH92_14570 ENOG4105EN6 Membrane CH92_14585 ENOG4105JJR Histidine kinase CH92_14590 ENOG4107EXC regulatoR CH92_14595 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH92_14600 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH92_14605 ENOG4108MIB CH92_14650 ENOG4107Y9U Membrane CH92_14655 ENOG4105ETT transcriptional Regulator, LysR family CH92_14660 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CH92_14680 ENOG4105C94 Transporter CH92_14685 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) CH92_14730 ENOG4105BZU Histidine kinase CH92_14735 ENOG4105FDP GntR family transcriptional regulator CH92_14750 ENOG4105C8Q Methyl-accepting chemotaxis CH92_14760 ENOG4105ENY Ethanolamine utilization protein eutH CH92_14775 ENOG4105CAY ferredoxin--nadp reductase CH92_14820 ENOG410804D Sensor Signal Transduction Histidine Kinase CH92_14825 ENOG4105D05 Receptor CH92_14845 ENOG4105E2V Glycosyltransferase 36 CH92_14855 ENOG4105E0K tonB-dependent siderophore receptor CH92_14860 ENOG4105CFP Peptidase U32 CH92_14880 ENOG4105F87 Dehydratase CH92_14895 ENOG4107SDU Methyl-accepting chemotaxis CH92_14905 ENOG4105F27 Major Facilitator CH92_14915 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CH92_14930 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CH92_14940 ENOG4105CW7 secretion protein, HlyD family CH92_14945 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH92_14950 ENOG4105CB5 ATP-dependent DNA helicase recG CH92_14970 ENOG4105CBC glutamate synthase CH92_14975 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CH92_14980 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CH92_14985 ENOG4105E98 transcriptional regulator DeoR family CH92_14990 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CH92_15010 ENOG4105CSR polyphosphate kinase 2 CH92_15015 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CH92_15040 ENOG4105D64 Mechanosensitive ion channel CH92_15050 ENOG4105ECY inositol monophosphatase CH92_15070 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CH92_15080 ENOG41081XQ Conserved Protein CH92_15090 ENOG41072GX Peptidase M22 Glycoprotease CH92_15105 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CH92_15120 ENOG4105UYK outer membrane protein a CH92_15135 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CH92_15140 ENOG4105MP9 class II Aldolase CH92_15145 ENOG4105CEY Amp-dependent synthetase and ligase CH92_15160 ENOG4105CHR reductase CH92_15165 ENOG4105C1G acyl-Coa dehydrogenase CH92_15175 ENOG4105CH5 extracellular solute-binding protein, family 7 CH92_15185 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_15195 ENOG4105CRK lysyL-tRNA synthetase CH92_15210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH92_15215 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH92_15220 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CH92_15230 ENOG4105E7W lamb ycsf family protein CH92_15235 ENOG4105P4J Allophanate hydrolase, subunit 1 CH92_15240 ENOG4107R7A Allophanate hydrolase subunit 2 CH92_15245 ENOG4105C5A transporter CH92_15250 ENOG4108VWS Yaeq family CH92_15255 ENOG4105W53 bacterioferritin-associated ferredoxin CH92_15260 ENOG4108UQY Iron-storage protein CH92_15265 ENOG4105M2J Glutaredoxin CH92_15270 ENOG4105DBV ornithine carbamoyltransferase CH92_15275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH92_15280 ENOG4108Z6B deaminase CH92_15295 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CH92_15300 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CH92_15310 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CH92_15315 ENOG4105E4C Lytic transglycosylase catalytic CH92_15325 ENOG4105CUY Mechanosensitive ion channel CH92_15330 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CH92_15335 ENOG4105DQ4 alcohol dehydrogenase CH92_15340 ENOG4105EMK carboxylate amino acid amine transporter CH92_15345 ENOG4105RWS endonuclease I CH92_15350 ENOG4108R5S membrane CH92_15365 ENOG4105CHM Aminotransferase CH92_15370 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CH92_15375 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH92_15380 ENOG4105N21 Membrane CH92_15385 ENOG4105CUT histidyl-tRNA synthetase CH92_15390 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CH92_15405 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CH92_15410 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CH92_15415 ENOG4105WVQ Fe-S assembly protein IscX CH92_15420 ENOG4108ZIT Ferredoxin, 2FE-2S CH92_15425 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CH92_15430 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CH92_15435 ENOG4108Z4V iron-sulfur cluster assembly CH92_15440 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CH92_15445 ENOG4105C3J Cysteine desulfurase CH92_15450 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CH92_15465 ENOG4105ECY inositol monophosphatase CH92_15470 ENOG4107MBR 17 kDa surface antigen CH92_15475 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH92_15480 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH92_15485 ENOG4105VIE preprotein translocase, subunit YajC CH92_15515 ENOG4108K5H permease YjgP YjgQ family protein CH92_15520 ENOG4108M8S permease YjgP YjgQ family protein CH92_15525 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CH92_15530 ENOG4105MYG DNA polymerase iii, chi subunit CH92_15540 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CH92_15555 ENOG4105CBP Major Facilitator CH92_15560 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) CH92_15585 ENOG4106V8H Nucleoid-associated protein CH92_15590 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CH92_15600 ENOG41082IR Excinuclease ABC C subunit domain protein CH92_15605 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CH92_15610 ENOG4108Z66 YbaK ebsC protein CH92_15615 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CH92_15625 ENOG4105DZ2 Transcriptional regulator CH92_15650 ENOG4105VRT cytoplasmic protein CH92_15655 ENOG4105JXB ankyrin repeat-containing protein CH92_15665 ENOG4105F27 Major Facilitator CH92_15675 ENOG4105ENX hydrolase CH92_15685 ENOG41074H6 response regulator CH92_15690 ENOG4105RAK Histidine kinase CH92_15695 ENOG4107QWE )-transporter CH92_15725 ENOG4106BRA Membrane CH92_15740 ENOG4105C6Z Gluconate CH92_15745 ENOG4105CYM Glutathione S-transferase CH92_15755 ENOG4105WH9 RNA polymerase CH92_15780 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) CH92_15790 ENOG4107TSN permease CH92_15795 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CH92_15800 ENOG4107653 Transcriptional regulator CH92_15815 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CH92_15820 ENOG4105CHR reductase CH92_15835 ENOG4105CQ7 ATP-dependent helicase CH92_15840 ENOG4108NVR Methyl-accepting chemotaxis CH92_15845 ENOG4105CEY Amp-dependent synthetase and ligase CH92_15850 ENOG4105CEY Amp-dependent synthetase and ligase CH92_15855 ENOG4108Z7G MaoC domain protein dehydratase CH92_15860 ENOG4108NVR Methyl-accepting chemotaxis CH92_15885 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CH92_15890 ENOG4107QRT dEAD DEAH box helicase CH92_15900 ENOG4105EMU Dehydrogenase CH92_15915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CH92_15935 ENOG4105C1J atp-dependent rna helicase CH92_15950 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH92_15965 ENOG4105R8A Heat shock protein CH92_15970 ENOG4108I5G Major Facilitator superfamily CH92_15975 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CH92_15990 ENOG4105D4Y metalloprotease CH92_16000 ENOG4107T9Q phosphonate abc transporter CH92_16005 ENOG4105D5T phosphonate abc transporter CH92_16025 ENOG4105CP9 extracellular ligand-binding receptor CH92_16030 ENOG4105C32 Amino acid ABC transporter (Permease) CH92_16035 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CH92_16040 ENOG4105C0Z ABC transporter CH92_16045 ENOG4108IV0 ABC, transporter CH92_16050 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CH92_16075 ENOG4107QUY Guanine deaminase CH92_16080 ENOG4105DSE periplasmic solute binding protein CH92_16085 ENOG4105CC5 ABC transporter CH92_16090 ENOG4105FDK ABC transporter CH92_16095 ENOG4107XBN GntR Family Transcriptional Regulator CH92_16100 ENOG4105C7N Xanthine uracil vitamin C permease CH92_16110 ENOG4105VT2 5-hydroxyisourate hydrolase CH92_16125 ENOG4105DHG Allantoate amidinohydrolase CH92_16130 ENOG4108Z2U ureidoglycolate hydrolase CH92_16140 ENOG4105C2W permease CH92_16145 ENOG4105CKD glutathione-regulated potassium-efflux system protein CH92_16150 ENOG4105C2W permease CH92_16160 ENOG41069D7 Methyl-accepting chemotaxis CH92_16165 ENOG4105BZU Histidine kinase CH92_16175 ENOG4108R86 Transcriptional regulator CH92_16180 ENOG4105BZU Histidine kinase CH92_16200 ENOG4108V0P LemA family CH92_16225 ENOG4108NVR Methyl-accepting chemotaxis CH92_16230 ENOG410624X efflux transporter, rnd family, mfp subunit CH92_16235 ENOG4105BZS acriflavin resistance protein CH92_16245 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CH92_16250 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CH92_16260 ENOG4105FS0 cytoplasmic membrane protein CH92_16270 ENOG4105CHR reductase CH92_16280 ENOG41080UX Methyltransferase CH92_16290 ENOG4105D64 Mechanosensitive ion channel CH92_16295 ENOG4108VPT UPF0234 protein CH92_16300 ENOG4108VYJ response regulator receiver protein CH92_16305 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CH92_16310 ENOG4105BZU Histidine kinase CH92_16315 ENOG4108WBT adenosyltransferase CH92_16335 ENOG4108JU3 Alkyl hydroperoxide reductase CH92_16345 ENOG4105M6F mutator MutT protein CH92_16350 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CH92_16355 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CH92_16385 ENOG4105D25 secreted protein CH92_16395 ENOG4108UGV hypoxanthine phosphoribosyltransferase CH92_16400 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CH92_16405 ENOG4105C2W permease CH92_16415 ENOG41061N2 exported protein CH92_16420 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CH92_16425 ENOG4105D06 uba thif-type nad fad binding protein CH92_16430 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CH92_16435 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CH92_16440 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CH92_16445 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein CH92_16450 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CH92_16455 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CH92_16470 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CH92_16475 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CH92_16485 ENOG4105C3G gtp-binding protein CH92_16490 ENOG4108RB4 3-methyladenine DNA glycosylase CH92_16495 ENOG4107RN3 metallophosphoesterase CH92_16505 ENOG4105HEI LysR family (Transcriptional regulator CH92_16510 ENOG4105F27 Major Facilitator CH92_16515 ENOG4105CV8 reductase CH92_16530 ENOG4105ESI atpase involved in dna repair CH92_16550 ENOG4105EPF Outer membrane porin CH92_16555 ENOG4105CH7 arginosuccinase CH92_16565 ENOG4107RSM transcriptional regulator CH92_16580 ENOG41077A9 carbonic anhydrase CH92_16585 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase CH92_16590 ENOG4108K4C ec 3.1.3.12 CH92_16600 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CH92_16610 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CH92_16660 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CH92_16665 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) CH92_16670 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CH92_16675 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CH92_16680 ENOG4108ZP8 Acetolactate synthase small subunit CH92_16685 ENOG4105C7K acetolactate synthase CH92_16695 ENOG4105WP7 tRNA pseudouridine synthase C CH92_16705 ENOG4105BZ4 penicillin-binding protein CH92_16715 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CH92_16755 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CH92_16760 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CH92_16765 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CH92_16770 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CH92_16775 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CH92_16785 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH92_16790 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CH92_16795 ENOG4105DC1 bifunctional purine biosynthesis protein purh CH92_16800 ENOG4105C12 Phosphoribosylglycinamide synthetase CH92_16805 ENOG4105BZU Histidine kinase CH92_16810 ENOG4107E6A Cytochrome p-450 CH92_16825 ENOG4105RK9 auxin efflux carrier CH92_16850 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH92_16855 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CH92_16860 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CH92_16865 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CH92_16870 ENOG4105CPF Cell wall formation (By similarity) CH92_16875 ENOG4105DFU Cell wall formation (By similarity) CH92_16880 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CH92_16885 ENOG4105CNI cell division protein FtsW CH92_16890 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CH92_16895 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CH92_16900 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CH92_16905 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CH92_16910 ENOG4105CJN penicillin-binding protein CH92_16920 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CH92_16930 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CH92_16935 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) CH92_16940 ENOG41082RQ UPF0102 protein CH92_16945 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CH92_16950 ENOG4105W4M Transport-associated protein CH92_16955 ENOG4105KB2 stringent starvation protein b CH92_16960 ENOG4107MKT Stringent starvation protein a CH92_16965 ENOG4105EIX cytochrome c1 CH92_16970 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CH92_16975 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CH92_16980 ENOG4108UJD 30S ribosomal protein S9 CH92_16985 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CH92_16990 ENOG4105CPC Aldo Keto reductase CH92_17020 ENOG4107QHF type ii secretion system protein e CH92_17025 ENOG4105KHS type IV fimbrial pilin protein CH92_17040 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CH92_17045 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CH92_17055 ENOG4107QNR UPF0135 protein CH92_17060 ENOG4105C0H protease CH92_17065 ENOG4105CIH Imidazole acetol-phosphate transaminase CH92_17070 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CH92_17075 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CH92_17080 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CH92_17105 ENOG4107PE3 Mammalian cell entry related domain protein CH92_17110 ENOG4105CY3 ABC transporter, permease CH92_17115 ENOG4105DHJ ABC, transporter CH92_17120 ENOG4105C2X Arabinose 5-phosphate isomerase CH92_17125 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CH92_17135 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CH92_17140 ENOG4108IUZ ABC transporter CH92_17145 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH92_17150 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA CH92_17155 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CH92_17160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CH92_17165 ENOG41080Z8 PHOSPHOCARRIER protein CH92_17170 ENOG4105CMS peptidase U62, modulator of DNA gyrase CH92_17175 ENOG4105N42 UPF0307 protein CH92_17180 ENOG4105D1U peptidase U62 modulator of DNA gyrase CH92_17195 ENOG4105C03 ribonuclease CH92_17200 ENOG4108Z03 MAF-like protein CH92_17210 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CH92_17215 ENOG4105DFF Rod shape-determining protein mreb CH92_17220 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CH92_17230 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CH92_17235 ENOG4105K6T rare lipoprotein A CH92_17240 ENOG4105FEU K -dependent Na -Ca exchanger CH92_17260 ENOG4105DR5 peptidase CH92_17280 ENOG4105TX3 Histidine kinase CH92_17310 ENOG4108ESX Receptor CH92_17315 ENOG4107E2E PKHD-type hydroxylase CH92_17325 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CH92_17330 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CH92_17335 ENOG4108W1A pseudouridine synthase CH92_17365 ENOG4106849 propeptide, pepSY amd peptidase M4 CH92_17370 ENOG4105XJC Two component transcriptional regulator (Winged helix family CH92_17375 ENOG4105IFJ Histidine kinase CH92_17400 ENOG4107RH8 nuclease SbcCD subunit D CH92_17405 ENOG4105EYH Exonuclease CH92_17410 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH92_17425 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) CH92_17435 ENOG4105CH6 catalase CH92_17455 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CH92_17460 ENOG4105DZG Dehydrogenase CH92_17465 ENOG4105DM4 PTS System CH92_17470 ENOG4105DE4 1-phosphofructokinase CH92_17475 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CH92_17480 ENOG4107B7Y DNA-binding transcriptional regulator FruR CH92_17490 ENOG4106371 Methyltransferase CH92_17520 ENOG4107R73 Mate efflux family protein CH92_17555 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CH92_17660 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CH92_17675 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding CH92_17680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CH92_17685 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CH92_17690 ENOG4105EJC lysr family transcriptional regulator CH92_17700 ENOG4105C2C drug resistance transporter, Bcr CflA CH92_17705 ENOG4108IG5 Transcriptional regulator CH92_17720 ENOG4108Z6Z Transcriptional regulator CH92_17730 ENOG4108UWD Iron-storage protein CH92_17735 ENOG4105D0S secretion protein (HlyD CH92_17745 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH92_17755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH92_17765 ENOG4105EYA deoxyribonuclease CH92_17780 ENOG4105C8Q Methyl-accepting chemotaxis CH92_17790 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH92_17795 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CH92_17800 ENOG4105ECQ AraC Family Transcriptional Regulator CH92_17805 ENOG4105D6Z AFG1 family ATPase CH92_17810 ENOG4105C31 Tryptophanyl-tRNA synthetase CH92_17825 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CH92_17840 ENOG4105CEP NADH dehydrogenase CH92_17860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH92_17865 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CH92_17870 ENOG4105C34 Pseudouridine synthase CH92_17875 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CH92_17885 ENOG4107TUY Histidine kinase CH92_17890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_17900 ENOG4105BZU Histidine kinase CH92_17905 ENOG4108W2P Methyl-accepting chemotaxis CH92_17910 ENOG4105CCT upf0313 protein CH92_17940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CH92_17955 ENOG4105CDU Replicative dna helicase CH92_17960 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CH92_17970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CH92_17975 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CH92_17985 ENOG4105C2N RNA methyltransferase TrmH family group 3 CH92_17990 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CH92_18005 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CH92_18015 ENOG4105EPW hflc protein CH92_18020 ENOG4107QJR hflk protein CH92_18025 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CH92_18030 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CH92_18035 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CH92_18040 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CH92_18045 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CH92_18050 ENOG4105K8N protein family UPF0079, ATPase CH92_18055 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CH92_18060 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CH92_18070 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CH92_18075 ENOG4105DFU Cell wall formation (By similarity) CH92_18080 ENOG4105C26 Dehydrogenase CH92_18085 ENOG4105CUB amino acid CH92_18090 ENOG4105CPD ethanolamine ammonia-lyase CH92_18095 ENOG4107FQ9 ethanolamine ammonia-lyase CH92_18110 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) CH92_18115 ENOG4105F0N pyrophosphate phospho-hydrolase CH92_18120 ENOG4105R0I Feruloyl esterase CH92_18125 ENOG4105D2S major facilitator superfamily CH92_18135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CH92_18140 ENOG4107F9Y LysR family transcriptional regulator CH92_18150 ENOG4105JSC dimethylmenaquinone methyltransferase CH92_18180 ENOG4108U1V ABC transporter, permease CH92_18185 ENOG4105E0A ABC, transporter CH92_18190 ENOG4105RD8 TRAP dicarboxylate transporter CH92_18200 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_18205 ENOG41090KI Outer membrane porin CH92_18210 ENOG4105CQZ Histidine kinase CH92_18215 ENOG4105WEF catalase CH92_18225 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) CH92_18240 ENOG4105PGM cation diffusion facilitator family transporter CH92_18250 ENOG4105EJ9 Membrane CH92_18255 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CH92_18260 ENOG4105CTB Polyprenyl synthetase CH92_18265 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CH92_18275 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) CH92_18280 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CH92_18290 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CH92_18295 ENOG4108WIW Aspartyl protease CH92_18305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CH92_18310 ENOG4107YIM Involved in the transcription termination process (By similarity) CH92_18315 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CH92_18320 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CH92_18335 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CH92_18350 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CH92_18360 ENOG4107QR8 Thioredoxin CH92_18370 ENOG4105C29 acyl-CoA thioesterase CH92_18380 ENOG4105DGU Histone deacetylase CH92_18385 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH92_18400 ENOG4105C1J atp-dependent rna helicase CH92_18415 ENOG4108S3I UPF0259 membrane protein CH92_18435 ENOG4105CQ7 ATP-dependent helicase CH92_18450 ENOG41076HS cation diffusion facilitator family transporter CH92_18455 ENOG4108XM1 transcriptional regulator AsnC family CH92_18465 ENOG4108R99 pseudouridine synthase CH92_18475 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein CH92_18480 ENOG4105C32 Amino acid ABC transporter (Permease) CH92_18485 ENOG4105CNN ABC, transporter CH92_18490 ENOG4105C0Z ABC transporter CH92_18495 ENOG4108IV0 ABC, transporter CH92_18510 ENOG4108IV0 ABC, transporter CH92_18515 ENOG4105C0Z ABC transporter CH92_18520 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CH92_18525 ENOG4105C32 Amino acid ABC transporter (Permease) CH92_18530 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CH92_18535 ENOG4108YZ9 Urea amidohydrolase subunit gamma CH92_18545 ENOG4105KI2 Urea amidohydrolase subunit beta CH92_18550 ENOG4105CQM Urea amidohydrolase subunit alpha CH92_18555 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CH92_18560 ENOG4105BZU Histidine kinase CH92_18570 ENOG4105KSC Transcriptional regulator, TraR DksA family CH92_18600 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CH92_18605 ENOG4105IY8 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CH92_18610 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CH92_18620 ENOG4105FYV Amp nucleosidase CH92_18630 ENOG4105C7B Threonine dehydratase CH92_18635 ENOG4105CSU acyl-Coa dehydrogenase CH92_18640 ENOG4105BZU Histidine kinase CH92_18650 ENOG4105DWF phosphomethylpyrimidine kinase CH92_18655 ENOG4107S5G Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CH92_18660 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CH92_18680 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CH92_18685 ENOG4105C9A Phoh family CH92_18690 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CH92_18695 ENOG4108JU5 Magnesium and cobalt efflux protein CH92_18700 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CH92_18715 ENOG4105C8T Leucyl-tRNA synthetase CH92_18735 ENOG4105CVE Lytic murein transglycosylase CH92_18750 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CH92_18755 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CH92_18760 ENOG41084BA UPF0250 protein CH92_18765 ENOG4105DZ1 carboxypeptidase CH92_18775 ENOG4105CVE Lytic murein transglycosylase CH92_18780 ENOG4105CNI cell division protein FtsW CH92_18785 ENOG4105CJN penicillin-binding protein CH92_18790 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CH92_18800 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CH92_18805 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CH92_18810 ENOG4108KF1 Membrane CH92_18820 ENOG41067MG lrgb family CH92_18840 ENOG4105K4T epimerase CH92_18845 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CH92_18855 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CH92_18860 ENOG4105ER2 Ompa motb domain protein CH92_18865 ENOG4107RD7 Flagellar Motor Protein, MotA CH92_18875 ENOG4105KHC sulfurtransferase CH92_18880 ENOG4105DJ4 phosphatidylserine decarboxylase CH92_18895 ENOG4105EAC phosphoserine phosphatase CH92_18910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH92_18925 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH92_18930 ENOG4105IPS esterase CH92_18935 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CH92_18945 ENOG41087AY ADP-Ribose pyrophosphatase CH92_18960 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CH92_18965 ENOG4105DFG type I secretion outer membrane protein CH92_18970 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CH92_18975 ENOG410814C multidrug resistance protein CH92_18980 ENOG41087SS fad dependent oxidoreductase CH92_18985 ENOG4107SET aldo keto reductase CH92_18995 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CH92_19010 ENOG4105BZ1 (ABC) transporter CH92_19035 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CH92_19040 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) CH92_19055 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CH92_19075 ENOG4107543 (lipo)polysaccharide CH92_19080 ENOG4107RJ7 Glycosyl transferase (Group 1 CH92_19085 ENOG4105D16 lipopolysaccharide heptosyltransferase i CH92_19090 ENOG4105XA0 heptosyltransferase ii CH92_19095 ENOG4105CM2 brancheD-chain amino acid aminotransferase CH92_19100 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CH92_19105 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CH92_19110 ENOG4107QSN dihydrolipoamide acetyltransferase CH92_19120 ENOG4105BZU Histidine kinase CH92_19125 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CH92_19130 ENOG4105CSU acyl-Coa dehydrogenase CH92_19135 ENOG4105CSU acyl-Coa dehydrogenase CH92_19140 ENOG4106TD9 Diguanylate cyclase CH92_19145 ENOG4105CSU acyl-Coa dehydrogenase CH92_19165 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CH92_19170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CH92_19175 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CH92_19180 ENOG4105MJ2 Competence protein CH92_19185 ENOG4105E27 serine threonine protein kinase CH92_19190 ENOG4105D6S protein involved in catabolism of external DNA CH92_19200 ENOG4105IJY hydroxylase CH92_19205 ENOG4105FE1 phytoene synthase CH92_19210 ENOG4105EWK phytoene CH92_19220 ENOG41087PP glycosyltransferase MGT family CH92_19230 ENOG4108UK3 Polyprenyl synthetase CH92_19235 ENOG4105CSU acyl-Coa dehydrogenase CH92_19240 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CH92_19245 ENOG4105EGS Mechanosensitive ion channel CH92_19250 ENOG4105CNG UPF0061 protein CH92_19255 ENOG4108WC9 type VI secretion system effector, hcp1 family CH92_19365 ENOG4105BZU Histidine kinase CH92_19370 ENOG4107Z5C methylesterase CH92_19375 ENOG4105BZU Histidine kinase CH92_19380 ENOG4105BZU Histidine kinase CH92_19405 ENOG4107QX8 SPFH domain, Band 7 family protein CH92_19420 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CH92_19425 ENOG4105FR1 rard protein CH92_19430 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH92_19435 ENOG4107QP3 malate synthase g CH92_19440 ENOG4105C8Q Methyl-accepting chemotaxis CH92_19465 ENOG4108SF5 RNA Polymerase CH92_19470 ENOG4108S3W Anti-feci sigma factor, fecr CH92_19495 ENOG4107QN1 sodium solute CH92_19510 ENOG4105C1J atp-dependent rna helicase CH92_19520 ENOG4105EM2 membrane CH92_19525 ENOG4105CBX hi0933 family CH92_19555 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_19560 ENOG4105D2N Aldolase CH92_19575 ENOG4105BZA Phosphoglycerate kinase CH92_19580 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH92_19585 ENOG4105CV1 Transketolase (EC 2.2.1.1) CH92_19590 ENOG4105ETT transcriptional Regulator, LysR family CH92_19605 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) CH92_19610 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CH92_19620 ENOG4105E3A (ABC) transporter CH92_19625 ENOG4105DA5 (ABC) transporter CH92_19630 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) CH92_19650 ENOG4105EEQ Na H antiporter CH92_19655 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CH92_19660 ENOG4105SYT Methylenetetrahydrofolate reductase CH92_19670 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH92_19675 ENOG4105BZS acriflavin resistance protein CH92_19680 ENOG4105C1P efflux transporter, rnd family, mfp subunit CH92_19685 ENOG4108YYC ycei family CH92_19690 ENOG4105DS1 cytochrome b561 CH92_19700 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CH92_19715 ENOG4105CBS Chea signal transduction histidine kinase CH92_19720 ENOG4105BZU Histidine kinase CH92_19725 ENOG4105C8Q Methyl-accepting chemotaxis CH92_19730 ENOG4108ZGA chew protein CH92_19735 ENOG4105M3Z response regulator CH92_19740 ENOG4108UNF response regulator CH92_19745 ENOG4105D7Z glutathione synthase CH92_19755 ENOG4108UJU UPF0301 protein CH92_19770 ENOG4105CXT aspartate transcarbamylase CH92_19775 ENOG4105CD3 dihydroorotase CH92_19795 ENOG4105CZX twitching motility protein CH92_19800 ENOG4105CZX twitching motility protein CH92_19805 ENOG4105DFA alanine racemase domain protein CH92_19810 ENOG4105II7 pyrroline-5-carboxylate reductase CH92_19815 ENOG4108VIA integral membrane protein CH92_19820 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CH92_19825 ENOG4105DWV Homoserine O-trans-acetylase CH92_19830 ENOG4105DWV Homoserine O-trans-acetylase CH92_19840 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH92_19845 ENOG4105CSA Coproporphyrinogen iii oxidase CH92_19855 ENOG4105D25 secreted protein CH92_19860 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CH92_19865 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CH92_19870 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CH92_19880 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CH92_19890 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH92_19895 ENOG4105CRP Part of the ABC transporter FtsEX involved in CH92_19900 ENOG4105CAK Cell division ATP-binding protein ftsE CH92_19905 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CH92_19920 ENOG4106H78 methyltransferase CH92_19930 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CH92_19935 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CH92_19945 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CH92_19955 ENOG4108Z0Z intracellular protease Pfpi family CH92_19960 ENOG4105DR4 Methyltransferase CH92_19970 ENOG4108K01 transcriptional regulator CH92_19975 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type CH92_19990 ENOG4105C01 Dihydroxy-acid dehydratase CH92_20000 ENOG4105C2W permease CH92_20010 ENOG4105C2W permease CH92_20015 ENOG4105D5U fad dependent oxidoreductase CH92_20035 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CH92_20040 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CH92_20080 ENOG4105EXG Transcriptional regulator CH92_20085 ENOG4108UTW Plays a role in the regulation of phosphate uptake CH92_20090 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CH92_20095 ENOG4105E2Z phosphate ABC transporter (Permease CH92_20100 ENOG4105C8U phosphate abc transporter CH92_20110 ENOG4105NAU thioesterase Superfamily protein CH92_20135 ENOG4107QYX exodeoxyribonuclease v alpha CH92_20150 ENOG4105EAM Na Pi-cotransporter CH92_20165 ENOG4105BZU Histidine kinase CH92_20170 ENOG4105DHQ Histidine kinase CH92_20180 ENOG4105EPF Outer membrane porin CH92_20225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_20230 ENOG4105ES5 Histidine kinase CH92_20240 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH92_20245 ENOG4105BZU Histidine kinase CH92_20260 ENOG4106RE7 Cytochrome CH92_20265 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CH92_20270 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CH92_20275 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CH92_20280 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CH92_20285 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component CH92_20295 ENOG4107QKW extracellular solute-binding protein family 1 CH92_20300 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CH92_20305 ENOG4105D0A hydroxylase CH92_20310 ENOG4107RAQ aminopeptidase CH92_20315 ENOG4105E07 UPF0149 protein CH92_20325 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CH92_20330 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CH92_20350 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CH92_20355 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) CH92_20360 ENOG4105VW4 glutaredoxin 3 CH92_20370 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CH92_20375 ENOG41063SB peptidase CH92_20380 ENOG4105CN1 protease CH92_20385 ENOG4105PXI polysaccharide deacetylase CH92_20405 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CH92_20415 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CH92_20420 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CH92_20435 ENOG4105CEN a g-specific adenine glycosylase CH92_20440 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) CH92_20450 ENOG4105CVR type I restriction-modification system CH92_20455 ENOG41082EK Restriction modification system DNA (Specificity CH92_20465 ENOG4108F3G Type I restriction-modification system, R subunit CH92_20475 ENOG4105C94 Transporter CH92_20480 ENOG4108JEH abc transporter atp-binding protein CH92_20485 ENOG4105E89 ABC transporter CH92_20500 ENOG4105DSB aldose 1-epimerase CH92_20525 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CH92_20530 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CH92_20535 ENOG4107YNJ LysR family Transcriptional regulator CH92_20545 ENOG4108IJ0 Aspartate ammonia-lyase CH92_20565 ENOG4105HDK L-asparaginase CH92_20570 ENOG4105BZU Histidine kinase CH92_20575 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CH92_20580 ENOG4107RK2 ADP-ribose diphosphatase NudE CH92_20585 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CH92_20595 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CH92_20605 ENOG4108IEG Formate dehydrogenase Alpha subunit CH92_20610 ENOG4107QIZ NADH dehydrogenase CH92_20620 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CH92_20640 ENOG4105C0A alcohol dehydrogenase CH92_20645 ENOG4105CSU acyl-Coa dehydrogenase CH92_20650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH92_20665 ENOG4105BZU Histidine kinase CH92_20680 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CH92_20690 ENOG4107SET aldo keto reductase CH92_20700 ENOG4108NVR Methyl-accepting chemotaxis CH92_20705 ENOG4105C9U ATP-dependent DNA helicase RecQ CH92_20730 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CH92_20740 ENOG4105C6Y Udp-glucose 6-dehydrogenase CH92_20750 ENOG4105D3Q Sugar transferase CH92_20780 ENOG4105CKK Glycosyl transferase, family 2 CH92_20790 ENOG4107BJW polysaccharide deacetylase CH92_20820 ENOG4105VEJ Heat shock protein CH92_20825 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) CH92_20830 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) CH92_20835 ENOG4105E0F Histidine kinase CH92_20840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CH92_20845 ENOG4105BZM domain protein CH92_20855 ENOG4105D9M gamma-glutamylcysteine synthetase CH92_20875 ENOG4105CJ3 phosphate transporter CH92_20880 ENOG4107IX6 phosphate transport regulator CH92_20890 ENOG4107QHF type ii secretion system protein e CH92_20915 ENOG4108Z9K Osmotically inducible protein CH92_20920 ENOG4105CH5 extracellular solute-binding protein, family 7 CH92_20930 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_20975 ENOG4107T5V SNARE associated Golgi CH92_20995 ENOG4105BZ9 Cytochrome C oxidase, subunit I CH92_21000 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CH92_21020 ENOG4105DHJ ABC, transporter CH92_21025 ENOG4108SNX Mammalian cell entry related domain protein CH92_21040 ENOG4105C1B dTDP-glucose 4-6-dehydratase CH92_21050 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CH92_21060 ENOG4105CQZ Histidine kinase CH92_21065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH92_21070 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_21075 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ CH92_21080 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_21105 ENOG4105D38 putrescine abc transporter CH92_21110 ENOG4105F38 ABC transporter, permease CH92_21115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH92_21120 ENOG4108HM4 ABC transporter CH92_21130 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CH92_21135 ENOG4105CFQ glutamine synthetase CH92_21140 ENOG4108Z86 Glutamine amidotransferase CH92_21145 ENOG4105CFQ glutamine synthetase CH92_21170 ENOG4105DWY Agmatine deiminase CH92_21175 ENOG4105BZU Histidine kinase CH92_21185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CH92_21190 ENOG4105BZU Histidine kinase CH92_21195 ENOG4108MRH transcriptional regulatory protein CH92_21200 ENOG4105BZU Histidine kinase CH92_21205 ENOG4105BZU Histidine kinase CH92_21210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CH92_21225 ENOG4107QJZ Glycosyl transferase, family 2 CH92_21230 ENOG4105C26 Dehydrogenase CH92_21235 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CH92_21240 ENOG4105W0E 50S ribosomal protein L33 CH92_21245 ENOG4105KDC 50s ribosomal protein l28 CH92_21270 ENOG4105CC9 acyl-Coa dehydrogenase CH92_21275 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH92_21280 ENOG4105C26 Dehydrogenase CH92_21295 ENOG4105CSU acyl-Coa dehydrogenase CH92_21300 ENOG4108RZE Tetr family transcriptional regulator CH92_21315 ENOG4105FDP GntR family transcriptional regulator CH92_21320 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CH92_21325 ENOG4105C1G acyl-Coa dehydrogenase CH92_21335 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_21360 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin CH92_21365 ENOG4107VHA regulatoR CH92_21370 ENOG4105DZC cytosine deaminase CH92_21385 ENOG4108JQ9 ABC transporter CH92_21405 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) CH92_21410 ENOG4108R86 Transcriptional regulator CH92_21415 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) CH92_21420 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) CH92_21425 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) CH92_21430 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CH92_21435 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) CH92_21440 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CH92_21445 ENOG4105KWG Pfam:DUF1696 CH92_21460 ENOG4105DMF Dehydrogenase CH92_21465 ENOG4105C5I Dehydrogenase CH92_21490 ENOG4105CXK mandelate racemase muconate lactonizing CH92_21495 ENOG4105ETE Transcriptional regulator (LacI family CH92_21500 ENOG4105C01 Dihydroxy-acid dehydratase CH92_21520 ENOG4108K70 Transcriptional regulator CH92_21525 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH92_21535 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH92_21540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CH92_21560 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) CH92_21565 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CH92_21575 ENOG4105W39 Membrane CH92_21615 ENOG4108S3W Anti-feci sigma factor, fecr CH92_21620 ENOG4108SF5 RNA Polymerase CH92_21625 ENOG41060X7 Protein of unknown function (DUF3617) CH92_21635 ENOG4105CKI cobalamin synthesis protein CH92_21650 ENOG4105BZU Histidine kinase CH92_21660 ENOG4105CQZ Histidine kinase CH92_21700 ENOG4105E0K tonB-dependent siderophore receptor CH92_21710 ENOG4108SF5 RNA Polymerase CH92_21745 ENOG4105F9F transposase CH92_21755 ENOG4105D9P serine threonine protein kinase CH92_21780 ENOG4105CFI type iii restriction protein res subunit CH92_21820 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CH92_21825 ENOG410804X Transcriptional regulator CH92_21830 ENOG4105C8Q Methyl-accepting chemotaxis CH92_21835 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CH92_21840 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CH92_21845 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CH92_21850 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CH92_21855 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CH92_21860 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH92_21865 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH92_21870 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH92_21880 ENOG41064MJ ATP synthase, subunit I CH92_21885 ENOG4105FA0 parb-like partition protein CH92_21890 ENOG4107QJE Chromosome Partitioning Protein CH92_21895 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CH92_21900 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CH92_21905 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CH92_21910 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CH92_21915 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CH92_21920 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)