locus-tag class description AOC03_00010 ENOG4105CD8 aminopeptidase N AOC03_00015 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AOC03_00020 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOC03_00025 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AOC03_00040 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AOC03_00055 ENOG4105YB8 TM2 domain containing protein AOC03_00100 ENOG4105JAB phenazine biosynthesis protein, phzf family AOC03_00105 ENOG4105KK4 UPF0060 membrane protein AOC03_00115 ENOG4105K8N protein family UPF0079, ATPase AOC03_00120 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AOC03_00125 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AOC03_00130 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOC03_00135 ENOG4105C2X Arabinose 5-phosphate isomerase AOC03_00140 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AOC03_00150 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AOC03_00155 ENOG4108IUZ ABC transporter AOC03_00160 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOC03_00170 ENOG4105CNI cell division protein FtsW AOC03_00195 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOC03_00200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOC03_00205 ENOG4105CDY transcriptional regulatory protein AOC03_00210 ENOG4105EYW Ion transport protein AOC03_00220 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AOC03_00225 ENOG4105VEQ Cold shock protein AOC03_00230 ENOG4105C1J atp-dependent rna helicase AOC03_00250 ENOG4105D4A Cell wall formation (By similarity) AOC03_00260 ENOG4105VEJ Heat shock protein AOC03_00270 ENOG4105C7B Threonine dehydratase AOC03_00280 ENOG4105DBV ornithine carbamoyltransferase AOC03_00285 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOC03_00290 ENOG4105CDU Replicative dna helicase AOC03_00300 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AOC03_00305 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AOC03_00310 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOC03_00320 ENOG4105CSU acyl-Coa dehydrogenase AOC03_00325 ENOG4105CSU acyl-Coa dehydrogenase AOC03_00330 ENOG4105BZU Histidine kinase AOC03_00335 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOC03_00340 ENOG4105SYT Methylenetetrahydrofolate reductase AOC03_00345 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AOC03_00350 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AOC03_00355 ENOG4105D64 Mechanosensitive ion channel AOC03_00365 ENOG4105DK0 Indole-3-glycerol phosphate synthase AOC03_00370 ENOG4108I0Q anthranilate phosphoribosyltransferase AOC03_00375 ENOG4105DDQ anthranilate synthase AOC03_00380 ENOG4105C5F glutamine synthetase AOC03_00395 ENOG4108V0P LemA family AOC03_00400 ENOG4105D0M Protease HtpX homolog AOC03_00420 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOC03_00425 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AOC03_00430 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AOC03_00435 ENOG4108JQ5 ABC transporter AOC03_00440 ENOG4105EUJ GTP cyclohydrolase i AOC03_00445 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AOC03_00455 ENOG4105C8P )-transporter AOC03_00460 ENOG4105EZE Cupin 4 family protein AOC03_00470 ENOG4107QTF adenylosuccinate lyase AOC03_00475 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOC03_00480 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AOC03_00485 ENOG4105M2J Glutaredoxin AOC03_00495 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AOC03_00510 ENOG4105DEN Luciferase family AOC03_00515 ENOG4107R11 Transcriptional regulator AOC03_00520 ENOG4108E7F Transporter AOC03_00525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOC03_00545 ENOG4108XM1 transcriptional regulator AsnC family AOC03_00550 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AOC03_00560 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOC03_00565 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AOC03_00570 ENOG4107QI1 Mate efflux family protein AOC03_00580 ENOG4105CSA Coproporphyrinogen iii oxidase AOC03_00595 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AOC03_00620 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AOC03_00625 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AOC03_00630 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOC03_00655 ENOG4105CG5 Glycosyl transferase (Group 1 AOC03_00665 ENOG4107TAE Glycosyl transferase (Group 1 AOC03_00670 ENOG4107TAE Glycosyl transferase (Group 1 AOC03_00690 ENOG4105C9M aspartyl-trna synthetase AOC03_00695 ENOG4105ERU peptidase AOC03_00720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOC03_00725 ENOG4107YD3 Thioesterase AOC03_00730 ENOG4105CGK Exodeoxyribonuclease III AOC03_00735 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AOC03_00745 ENOG4105EJQ L-serine dehydratase AOC03_00750 ENOG4105C2W permease AOC03_00770 ENOG4105VCQ rubredoxin AOC03_00775 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AOC03_00780 ENOG4107QV2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOC03_00785 ENOG4105CQC Prephenate dehydratase AOC03_00790 ENOG4105CIH Imidazole acetol-phosphate transaminase AOC03_00795 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AOC03_00800 ENOG4105FR1 rard protein AOC03_00805 ENOG4107ZVW dihydroneopterin aldolase AOC03_00820 ENOG4105K78 MarR family Transcriptional regulator AOC03_00825 ENOG4105D7W serine acetyltransferase AOC03_00845 ENOG4105C0B DNA polymerase III (alpha subunit) AOC03_00850 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOC03_00855 ENOG4105BZG amino acid carrier protein AOC03_00860 ENOG4105C26 Dehydrogenase AOC03_00865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOC03_00870 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOC03_00875 ENOG4105CTU Proline racemase AOC03_00885 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AOC03_00905 ENOG4105E3W Two component transcriptional regulator (Winged helix family AOC03_00910 ENOG4105E0F Histidine kinase AOC03_00915 ENOG4105FDP GntR family transcriptional regulator AOC03_00935 ENOG4108UTW Plays a role in the regulation of phosphate uptake AOC03_00940 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOC03_00945 ENOG4105E2Z phosphate ABC transporter (Permease AOC03_00950 ENOG4105C8U phosphate abc transporter AOC03_00955 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AOC03_00960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOC03_00965 ENOG4105DHQ Histidine kinase AOC03_00970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOC03_00990 ENOG4105XJC Two component transcriptional regulator (Winged helix family AOC03_00995 ENOG4105DHQ Histidine kinase AOC03_01010 ENOG4105CJ2 (LipO)protein AOC03_01025 ENOG4107T5V SNARE associated Golgi AOC03_01030 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AOC03_01040 ENOG4107R1I NAD-dependent malic enzyme AOC03_01050 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AOC03_01075 ENOG4105DSY exodeoxyribonuclease V, gamma AOC03_01080 ENOG4107QKA exodeoxyribonuclease V beta AOC03_01085 ENOG4107QYX exodeoxyribonuclease v alpha AOC03_01100 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AOC03_01105 ENOG4105KD1 integral membrane protein AOC03_01110 ENOG4105C2W permease AOC03_01120 ENOG4105DXD 2-methylcitrate dehydratase AOC03_01140 ENOG4105C7F AcnD-accessory protein PrpF AOC03_01150 ENOG4108I0Z Aconitate hydratase AOC03_01155 ENOG4105BZN citrate synthase AOC03_01160 ENOG4105CR4 methylisocitrate lyase AOC03_01165 ENOG4105K3M )-transporter AOC03_01170 ENOG4108KB2 LysR family Transcriptional regulator AOC03_01180 ENOG4105DR9 pseudouridine synthase AOC03_01185 ENOG4108JQ1 Dehydrogenase AOC03_01190 ENOG4105FE9 pseudouridine synthase AOC03_01210 ENOG4105CSV Glutaminase AOC03_01215 ENOG4108IJ0 Aspartate ammonia-lyase AOC03_01220 ENOG4105CK2 sodium dicarboxylate symporter AOC03_01225 ENOG4107NQ8 LysR family Transcriptional regulator AOC03_01230 ENOG4108K3A Glutathione S-transferase AOC03_01240 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AOC03_01285 ENOG4105MP0 transposase AOC03_01340 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AOC03_01355 ENOG4107QRT dEAD DEAH box helicase AOC03_01465 ENOG4105FQ6 thiopurine methyltransferase AOC03_01500 ENOG4105XDF Protein of unknown function (DUF1272) AOC03_01510 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein AOC03_01515 ENOG4108594 Permease of the drug metabolite transporter AOC03_01535 ENOG4107TIF Phenazine biosynthesis protein, PhzF family AOC03_01555 ENOG4107Z3H Transcriptional regulator, TetR family AOC03_01565 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOC03_01585 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOC03_01630 ENOG4105DFP Integrase AOC03_01685 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOC03_01690 ENOG4108UQY Iron-storage protein AOC03_01695 ENOG4108YRX Iron-storage protein AOC03_01715 ENOG4105ECW sulfate abc transporter AOC03_01720 ENOG4108I5D sulfate abc transporter AOC03_01725 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AOC03_01730 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AOC03_01740 ENOG4107RIQ Sulfate adenylate transferase AOC03_01755 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AOC03_01760 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOC03_01765 ENOG4107RH8 nuclease SbcCD subunit D AOC03_01770 ENOG4105EYH Exonuclease AOC03_01790 ENOG4105C12 Phosphoribosylglycinamide synthetase AOC03_01795 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AOC03_01805 ENOG4105C8Y Acetylornithine aminotransferase AOC03_01810 ENOG4105JQN Transcriptional regulator AOC03_01815 ENOG4107QMP dna polymerase iii subunits gamma and tau AOC03_01820 ENOG4105CRK lysyL-tRNA synthetase AOC03_01830 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOC03_01845 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AOC03_01850 ENOG4107VQW regulatoR AOC03_01855 ENOG4105BZU Histidine kinase AOC03_01865 ENOG4105CQ7 ATP-dependent helicase AOC03_01875 ENOG4107QUY Guanine deaminase AOC03_01885 ENOG4105C7W Xanthine dehydrogenase AOC03_01890 ENOG4108HR6 Dehydrogenase AOC03_01900 ENOG4105C26 Dehydrogenase AOC03_01905 ENOG4105C7N Xanthine uracil vitamin C permease AOC03_01910 ENOG4105E02 MotA TolQ exbB proton channel AOC03_01915 ENOG4105M8F Biopolymer transport protein exbD tolR AOC03_01925 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AOC03_01935 ENOG4105EWK phytoene AOC03_01965 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOC03_01970 ENOG4105C34 Pseudouridine synthase AOC03_01975 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AOC03_01980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOC03_01985 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOC03_02010 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOC03_02025 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOC03_02030 ENOG4105XPH Ferredoxin AOC03_02035 ENOG4105C0H protease AOC03_02040 ENOG4107QNR UPF0135 protein AOC03_02050 ENOG4105E9H Lytic Murein transglycosylase AOC03_02050 ENOG4105E9H Lytic Murein transglycosylase AOC03_02060 ENOG4108JU6 CBS domain protein AOC03_02065 ENOG4105VIE preprotein translocase, subunit YajC AOC03_02070 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOC03_02075 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOC03_02080 ENOG4107R73 Mate efflux family protein AOC03_02095 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AOC03_02105 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AOC03_02140 ENOG4105D6Z AFG1 family ATPase AOC03_02155 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AOC03_02170 ENOG4105E0X reductase AOC03_02175 ENOG4108IJ7 Glycine betaine AOC03_02180 ENOG4108HQS Glycine betaine AOC03_02185 ENOG4107RGH Aldehyde dehydrogenase AOC03_02190 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AOC03_02210 ENOG4105PDP Short chain dehydrogenase AOC03_02215 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOC03_02220 ENOG4105C94 Transporter AOC03_02225 ENOG4105K59 histidine triad (HIT) protein AOC03_02235 ENOG4105C01 Dihydroxy-acid dehydratase AOC03_02245 ENOG4108K5P (LipO)protein AOC03_02250 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AOC03_02270 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AOC03_02275 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AOC03_02285 ENOG4105CUT histidyl-tRNA synthetase AOC03_02290 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AOC03_02305 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AOC03_02310 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AOC03_02320 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AOC03_02325 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AOC03_02335 ENOG4105D7N magnesium and cobalt transport protein CorA AOC03_02340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AOC03_02360 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOC03_02380 ENOG4107RZZ dna polymerase iii epsilon subunit AOC03_02395 ENOG4108R3D Electron transport complex AOC03_02400 ENOG4105CSM endonuclease III AOC03_02405 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AOC03_02420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOC03_02425 ENOG4105K5X acetyltransferase AOC03_02430 ENOG4105NBK UPF0345 protein AOC03_02435 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOC03_02445 ENOG4108Z0R Transferase AOC03_02455 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOC03_02460 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AOC03_02465 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AOC03_02480 ENOG4105C26 Dehydrogenase AOC03_02485 ENOG4105CBC glutamate synthase AOC03_02490 ENOG4108T58 Mg2 transport protein CorA AOC03_02495 ENOG4105C3G gtp-binding protein AOC03_02515 ENOG4108WWZ General secretion pathway protein J AOC03_02535 ENOG4105F8V Hydrolase, tatD family AOC03_02545 ENOG4107QHF type ii secretion system protein e AOC03_02550 ENOG4108R96 Methyltransferase, YaeB family AOC03_02555 ENOG4105DP0 ferredoxin-NADP reductase AOC03_02570 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOC03_02575 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AOC03_02600 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AOC03_02610 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOC03_02620 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AOC03_02625 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AOC03_02635 ENOG4105CK7 Sodium proline symporter AOC03_02650 ENOG4105C5H ABC transporter AOC03_02655 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOC03_02660 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOC03_02665 ENOG4105EIX cytochrome c1 AOC03_02670 ENOG4107MKT Stringent starvation protein a AOC03_02675 ENOG4105KB2 stringent starvation protein b AOC03_02680 ENOG4105DHP deoxycytidine triphosphate deaminase AOC03_02690 ENOG4105CJW magnesium transporter AOC03_02700 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOC03_02720 ENOG4108JJB ABC transporter AOC03_02725 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AOC03_02730 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOC03_02735 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOC03_02755 ENOG4105CAU Arsenical resistance protein, ArsH AOC03_02775 ENOG4108VKG metal-dependent hydrolase AOC03_02790 ENOG4108V06 Glutathione peroxidase AOC03_02795 ENOG4105E0X reductase AOC03_02800 ENOG4105CHM Aminotransferase AOC03_02810 ENOG4105CSR polyphosphate kinase 2 AOC03_02820 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AOC03_02830 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AOC03_02835 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AOC03_02840 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AOC03_02845 ENOG4105D2N Aldolase AOC03_02855 ENOG4105BZA Phosphoglycerate kinase AOC03_02865 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AOC03_02870 ENOG41061WM D-Alanyl-D-Alanine AOC03_02885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOC03_02895 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOC03_02905 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AOC03_02920 ENOG4105D3R alkyl hydroperoxide reductase AOC03_02935 ENOG4105CX6 glutaminyL-tRNA synthetase AOC03_02945 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AOC03_02950 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AOC03_02955 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOC03_02965 ENOG4105VW4 glutaredoxin 3 AOC03_02970 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AOC03_02975 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AOC03_02985 ENOG4105KWW Biogenesis protein AOC03_02990 ENOG4107QX9 Thiol disulfide interChange protein AOC03_02995 ENOG4105DA4 cytochrome c-type biogenesis protein AOC03_03005 ENOG4105CJN penicillin-binding protein AOC03_03010 ENOG4106H78 methyltransferase AOC03_03015 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AOC03_03020 ENOG4108UJD 30S ribosomal protein S9 AOC03_03030 ENOG4105C31 Tryptophanyl-tRNA synthetase AOC03_03035 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AOC03_03040 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AOC03_03055 ENOG4105CG5 Glycosyl transferase (Group 1 AOC03_03070 ENOG4108MRJ AOC03_03075 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AOC03_03080 ENOG4107WZ3 Transferase AOC03_03085 ENOG4105D3Q Sugar transferase AOC03_03090 ENOG4105CGN Glycosyl transferase (Group 1 AOC03_03130 ENOG4107QQG Dehydrogenase AOC03_03150 ENOG4105DAY polysaccharide export protein AOC03_03155 ENOG4105FE9 pseudouridine synthase AOC03_03175 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AOC03_03180 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOC03_03195 ENOG4108IYU L-aspartate oxidase AOC03_03200 ENOG4105DWU Membrane AOC03_03210 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AOC03_03215 ENOG4105D0A hydroxylase AOC03_03220 ENOG4105C9A Phoh family AOC03_03225 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AOC03_03230 ENOG4105D64 Mechanosensitive ion channel AOC03_03240 ENOG4105DP0 ferredoxin-NADP reductase AOC03_03245 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOC03_03250 ENOG4105C8S subunit m AOC03_03255 ENOG4105D65 subunit l AOC03_03265 ENOG4107UFS subunit j AOC03_03270 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOC03_03275 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AOC03_03280 ENOG4108IEH NADH dehydrogenase subunit g AOC03_03285 ENOG4107QIZ NADH dehydrogenase AOC03_03290 ENOG4105GKE subunit e AOC03_03295 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOC03_03300 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOC03_03305 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOC03_03315 ENOG4105K46 50S ribosomal protein l27 AOC03_03320 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AOC03_03335 ENOG4105BZS acriflavin resistance protein AOC03_03340 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AOC03_03345 ENOG4105D52 delta-aminolevulinic acid dehydratase AOC03_03355 ENOG4105C4R Atp-dependent dna helicase AOC03_03360 ENOG4105CJW magnesium transporter AOC03_03365 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AOC03_03370 ENOG4107QKV phosphomannomutase AOC03_03375 ENOG4105CAS nag kinase AOC03_03380 ENOG4105KUZ arsenate reductase AOC03_03385 ENOG4105C8T Leucyl-tRNA synthetase AOC03_03400 ENOG4105DJY efflux transporter, rnd family, mfp subunit AOC03_03405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOC03_03490 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOC03_03495 ENOG4105D6S protein involved in catabolism of external DNA AOC03_03505 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AOC03_03520 ENOG4105WVQ Fe-S assembly protein IscX AOC03_03530 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AOC03_03535 ENOG4105W8H transhydrogenase (subunit alpha AOC03_03540 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AOC03_03545 ENOG4105D1Q UPF0246 protein AOC03_03555 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AOC03_03560 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AOC03_03575 ENOG4107S2Z UPF0761 membrane protein AOC03_03580 ENOG4105EEQ Na H antiporter AOC03_03590 ENOG4105CD3 dihydroorotase AOC03_03595 ENOG4105CXT aspartate transcarbamylase AOC03_03600 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AOC03_03605 ENOG4108RWN rrna methyltransferase AOC03_03610 ENOG4105C10 Electron transfer flavoprotein AOC03_03615 ENOG4105BZJ Electron transfer flavoprotein AOC03_03620 ENOG4105VEQ Cold shock protein AOC03_03630 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOC03_03635 ENOG4108ZP8 Acetolactate synthase small subunit AOC03_03640 ENOG4105C7K acetolactate synthase AOC03_03650 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AOC03_03655 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOC03_03660 ENOG4109066 lysm domain bon superfamily protein AOC03_03670 ENOG4105CHR reductase AOC03_03675 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOC03_03690 ENOG4108BPE -transporting atpase AOC03_03695 ENOG4107RTD sua5 ycio yrdc ywlc family protein AOC03_03700 ENOG4108ZT0 50S ribosomal protein l17 AOC03_03705 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOC03_03710 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AOC03_03715 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AOC03_03720 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AOC03_03725 ENOG41085ZR 50S ribosomal protein L36 AOC03_03730 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOC03_03735 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AOC03_03740 ENOG4105VPB 50S ribosomal protein L30 AOC03_03745 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AOC03_03750 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AOC03_03755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOC03_03760 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AOC03_03765 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AOC03_03770 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AOC03_03775 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AOC03_03780 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AOC03_03785 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AOC03_03795 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AOC03_03800 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AOC03_03805 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AOC03_03810 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AOC03_03815 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AOC03_03820 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AOC03_03825 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AOC03_03830 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AOC03_03835 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AOC03_03840 ENOG4105C03 ribonuclease AOC03_03845 ENOG4108Z03 MAF-like protein AOC03_03855 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOC03_03860 ENOG4105DFF Rod shape-determining protein mreb AOC03_03870 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOC03_03875 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AOC03_03905 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOC03_03910 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AOC03_03915 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AOC03_03925 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AOC03_03935 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOC03_03945 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AOC03_03955 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AOC03_03960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOC03_03965 ENOG41072GX Peptidase M22 Glycoprotease AOC03_03975 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AOC03_03985 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AOC03_03990 ENOG4108YZ9 Urea amidohydrolase subunit gamma AOC03_03995 ENOG4105KI2 Urea amidohydrolase subunit beta AOC03_04000 ENOG4105CQM Urea amidohydrolase subunit alpha AOC03_04005 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AOC03_04010 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AOC03_04015 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AOC03_04030 ENOG4105KDC 50s ribosomal protein l28 AOC03_04035 ENOG4105W0E 50S ribosomal protein L33 AOC03_04055 ENOG4105DJV ribulose-phosphate 3-epimerase AOC03_04075 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AOC03_04090 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AOC03_04095 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AOC03_04100 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AOC03_04105 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOC03_04110 ENOG4105KME endoribonuclease L-psp AOC03_04115 ENOG4105C25 Primosomal protein n' AOC03_04120 ENOG4105PGM cation diffusion facilitator family transporter AOC03_04135 ENOG4105CKD glutathione-regulated potassium-efflux system protein AOC03_04145 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AOC03_04150 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AOC03_04155 ENOG4105Y3E Modulates RecA activity (By similarity) AOC03_04160 ENOG4107QPK )-transporter AOC03_04175 ENOG410863D Flavinator of succinate dehydrogenase AOC03_04180 ENOG4105EEI dihydropteroate synthase AOC03_04185 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOC03_04190 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AOC03_04195 ENOG4105HBR Rna-binding protein AOC03_04215 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOC03_04220 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOC03_04225 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AOC03_04230 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AOC03_04235 ENOG4105CPF Cell wall formation (By similarity) AOC03_04240 ENOG4105DFU Cell wall formation (By similarity) AOC03_04245 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOC03_04250 ENOG4105D7Z glutathione synthase AOC03_04255 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AOC03_04275 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AOC03_04285 ENOG4105CJR Integral membrane protein (MviN AOC03_04295 ENOG4107TCE N-acetyltransferase AOC03_04300 ENOG4105DTN riboflavin biosynthesis protein ribF AOC03_04310 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOC03_04320 ENOG4105E4C Lytic transglycosylase catalytic AOC03_04325 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOC03_04335 ENOG4105E0Y RtcB Protein AOC03_04340 ENOG4108NIW Leucine export protein LeuE AOC03_04345 ENOG4105CWC Acetylornithine deacetylase AOC03_04350 ENOG4105E07 UPF0149 protein AOC03_04370 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AOC03_04375 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AOC03_04380 ENOG41067S9 phage shock protein C, PspC AOC03_04385 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AOC03_04405 ENOG4107ZQV short-chain dehydrogenase reductase AOC03_04415 ENOG4105ERG peptidase m48, ste24p AOC03_04420 ENOG4105M85 Bola protein AOC03_04435 ENOG4105K63 Thioredoxin AOC03_04450 ENOG41080HT Transcriptional regulator, arsr family AOC03_04455 ENOG4105CHH sulfate transporter AOC03_04465 ENOG4107QPB Beta-lactamase domain protein AOC03_04470 ENOG4108JU3 Alkyl hydroperoxide reductase AOC03_04480 ENOG4105D3R alkyl hydroperoxide reductase AOC03_04485 ENOG4105C5Q Transcriptional regulator AOC03_04520 ENOG4106HNH Acyl-transferase AOC03_04535 ENOG4107QMS site-determining protein AOC03_04545 ENOG4105DS1 cytochrome b561 AOC03_04555 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AOC03_04560 ENOG4105CBS Chea signal transduction histidine kinase AOC03_04565 ENOG4105BZU Histidine kinase AOC03_04570 ENOG4105C8Q Methyl-accepting chemotaxis AOC03_04575 ENOG4108ZGA chew protein AOC03_04580 ENOG4105M3Z response regulator AOC03_04585 ENOG4108UNF response regulator AOC03_04595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOC03_04600 ENOG4105E0F Histidine kinase AOC03_04605 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOC03_04610 ENOG4108UMI ABC transporter, permease AOC03_04615 ENOG4105D01 (LipO)protein AOC03_04620 ENOG4105DZC cytosine deaminase AOC03_04625 ENOG4105F27 Major Facilitator AOC03_04635 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AOC03_04645 ENOG41060IM Heme exporter protein AOC03_04650 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AOC03_04655 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AOC03_04670 ENOG4105DGU Histone deacetylase AOC03_04680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOC03_04685 ENOG4105W5Q DNA repair protein (RadC AOC03_04690 ENOG4107QPN acyl-Coa dehydrogenase AOC03_04695 ENOG4105EJ9 Membrane AOC03_04700 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AOC03_04740 ENOG4105DUM transcriptional regulator, lysR family AOC03_04745 ENOG4105HMI Membrane AOC03_04750 ENOG4105VEQ Cold shock protein AOC03_04755 ENOG4105WD1 Membrane AOC03_04775 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOC03_04785 ENOG4105K8R UPF0145 protein AOC03_04820 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOC03_04825 ENOG4108YXA Membrane AOC03_04840 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AOC03_04845 ENOG4105CEY Amp-dependent synthetase and ligase AOC03_04850 ENOG4105CEY Amp-dependent synthetase and ligase AOC03_04855 ENOG4105CP2 von willebrand factor, type a AOC03_04860 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOC03_04875 ENOG4105CFC Transporter AOC03_04890 ENOG4107RUE extracellular solute-binding protein family 1 AOC03_04905 ENOG4105D49 3-dehydroquinate synthase AOC03_04910 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AOC03_04915 ENOG4105E4G Type IV pilus AOC03_04940 ENOG4108JQC penicillin-binding protein 1A AOC03_04945 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOC03_04950 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOC03_04955 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AOC03_04960 ENOG4108VZM 50s ribosomal protein L10 AOC03_04965 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AOC03_04970 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AOC03_04975 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOC03_04980 ENOG4105PM1 preprotein translocase subunit SecE AOC03_04990 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AOC03_04995 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AOC03_05000 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AOC03_05005 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AOC03_05020 ENOG4105CRQ synthase (Component I) AOC03_05025 ENOG4105CIH Imidazole acetol-phosphate transaminase AOC03_05030 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOC03_05035 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AOC03_05040 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOC03_05050 ENOG4105EBR Carboxylesterase AOC03_05055 ENOG4105W4M Transport-associated protein AOC03_05060 ENOG41082RQ UPF0102 protein AOC03_05065 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOC03_05080 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AOC03_05100 ENOG4105NRA 50s ribosomal protein l31 type b AOC03_05120 ENOG4108URH decarboxylase AOC03_05125 ENOG4108K5P (LipO)protein AOC03_05135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOC03_05140 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AOC03_05145 ENOG4105DJ4 phosphatidylserine decarboxylase AOC03_05155 ENOG4105CHU acetyl-coa acetyltransferase AOC03_05160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOC03_05165 ENOG4105CTB Polyprenyl synthetase AOC03_05170 ENOG41080IJ Diacylglycerol kinase AOC03_05185 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOC03_05190 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOC03_05195 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOC03_05200 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOC03_05205 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AOC03_05230 ENOG4105C75 arginyL-tRNA synthetase AOC03_05240 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AOC03_05250 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AOC03_05255 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOC03_05260 ENOG4105FQ6 thiopurine methyltransferase AOC03_05265 ENOG4105CVE Lytic murein transglycosylase AOC03_05280 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AOC03_05290 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AOC03_05295 ENOG41062QD Membrane AOC03_05310 ENOG4107QN1 sodium solute AOC03_05365 ENOG4105EMU Dehydrogenase AOC03_05385 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOC03_05390 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AOC03_05395 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOC03_05410 ENOG4105DUX Transporter AOC03_05420 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AOC03_05425 ENOG4108JU5 Magnesium and cobalt efflux protein AOC03_05435 ENOG4108ZZ3 UPF0260 protein AOC03_05445 ENOG4105CHR reductase AOC03_05455 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOC03_05465 ENOG4105CEN a g-specific adenine glycosylase AOC03_05470 ENOG4105C29 acyl-CoA thioesterase AOC03_05475 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AOC03_05480 ENOG4105C5I Dehydrogenase AOC03_05485 ENOG4105D3G Pseudouridine synthase AOC03_05490 ENOG4105K63 Thioredoxin AOC03_05495 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AOC03_05505 ENOG4105CGZ zinc metallopeptidase AOC03_05515 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AOC03_05520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOC03_05525 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AOC03_05530 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AOC03_05535 ENOG41082NX 50s ribosomal protein l35 AOC03_05545 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AOC03_05550 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AOC03_05555 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AOC03_05570 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AOC03_05580 ENOG4108UKZ OsmC family AOC03_05585 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AOC03_05590 ENOG4105CPQ Dehydrogenase AOC03_05600 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AOC03_05605 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AOC03_05610 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AOC03_05615 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOC03_05630 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AOC03_05635 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AOC03_05640 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AOC03_05645 ENOG4105K5M 30s ribosomal protein S16 AOC03_05650 ENOG4105E0F Histidine kinase AOC03_05660 ENOG4105JJR Histidine kinase AOC03_05665 ENOG4107EXC regulatoR AOC03_05670 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AOC03_05675 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AOC03_05680 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AOC03_05685 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AOC03_05690 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AOC03_05695 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AOC03_05700 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AOC03_05705 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AOC03_05725 ENOG4105FDK ABC transporter AOC03_05730 ENOG4105FAV ABC, transporter AOC03_05740 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AOC03_05745 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AOC03_05750 ENOG4105CNI cell division protein FtsW AOC03_05755 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AOC03_05760 ENOG4105CHH sulfate transporter AOC03_05800 ENOG4105DND Transcriptional regulator AOC03_05805 ENOG4107B2H carbonic anhydrase AOC03_05810 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AOC03_05815 ENOG4105DJ2 Major Facilitator Superfamily AOC03_05825 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOC03_05830 ENOG4105DHI Methyltransferase AOC03_05835 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AOC03_05840 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AOC03_05845 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOC03_05850 ENOG4105CJN penicillin-binding protein AOC03_05860 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AOC03_05865 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AOC03_05895 ENOG4107QM5 aconitate hydratase AOC03_05910 ENOG4105K5B UPF0225 protein AOC03_05925 ENOG4105E7A Glutamine amidotransferase AOC03_05940 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AOC03_05945 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AOC03_05955 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AOC03_05960 ENOG4108ZAI phosphatidylglycerophosphatase a AOC03_05965 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AOC03_05970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOC03_05985 ENOG4105C1P efflux transporter, rnd family, mfp subunit AOC03_05990 ENOG4105CB5 ATP-dependent DNA helicase recG AOC03_05995 ENOG4105D78 K07001 NTE family protein AOC03_06010 ENOG4108EKC n-acetylglutamate synthase AOC03_06015 ENOG4108V1T peptidylprolyl cis-trans isomerase AOC03_06025 ENOG4105CHR reductase AOC03_06035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOC03_06040 ENOG4105IPS esterase AOC03_06155 ENOG4105E3R (LipO)protein AOC03_06175 ENOG4105C22 threonyL-tRNA synthetase AOC03_06190 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOC03_06205 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AOC03_06210 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOC03_06220 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOC03_06230 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AOC03_06235 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AOC03_06240 ENOG4105CJ2 (LipO)protein AOC03_06250 ENOG4105DJ2 Major Facilitator Superfamily AOC03_06255 ENOG4108UJV acyl-CoA thioesterase i AOC03_06260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOC03_06270 ENOG4105JKW Valine--pyruvate aminotransferase AOC03_06280 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AOC03_06285 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AOC03_06305 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOC03_06310 ENOG4105C0P Mg chelatase subunit ChlI AOC03_06315 ENOG4105D4P Coproporphyrinogen iii oxidase AOC03_06325 ENOG4107QX8 SPFH domain, Band 7 family protein AOC03_06340 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOC03_06345 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOC03_06350 ENOG4105CFG Acts as a chaperone (By similarity) AOC03_06365 ENOG4107RN3 metallophosphoesterase AOC03_06370 ENOG4105DIN metallophosphoesterase AOC03_06375 ENOG4105ECP epimerase AOC03_06380 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOC03_06385 ENOG4105C79 DNA protecting protein DprA AOC03_06390 ENOG4108WZM domain protein AOC03_06400 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOC03_06410 ENOG4105BZU Histidine kinase AOC03_06420 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOC03_06425 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AOC03_06430 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOC03_06435 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOC03_06440 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AOC03_06445 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AOC03_06450 ENOG4105VG0 50S ribosomal protein l34 AOC03_06460 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOC03_06470 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOC03_06475 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AOC03_06480 ENOG4105E9F Enoyl-CoA hydratase AOC03_06485 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AOC03_06495 ENOG4105C87 Aminotransferase class I and II AOC03_06500 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOC03_06535 ENOG4107QJQ Mate efflux family protein AOC03_06555 ENOG4105DNZ Alpha Beta Hydrolase AOC03_06560 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOC03_06565 ENOG4105I08 Pseudouridine synthase AOC03_06580 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AOC03_06585 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AOC03_06595 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOC03_06600 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOC03_06610 ENOG4105DFU Cell wall formation (By similarity) AOC03_06620 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AOC03_06625 ENOG4105D9M gamma-glutamylcysteine synthetase AOC03_06635 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOC03_06640 ENOG4105C5H ABC transporter AOC03_06650 ENOG4105DVC DnaJ domain protein AOC03_06660 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AOC03_06675 ENOG4108M8S permease YjgP YjgQ family protein AOC03_06680 ENOG4108K5H permease YjgP YjgQ family protein AOC03_06685 ENOG4107Y49 methyltransferase AOC03_06695 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOC03_06700 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AOC03_06705 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AOC03_06715 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AOC03_06720 ENOG4108UJU UPF0301 protein AOC03_06725 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOC03_06730 ENOG4105NBK UPF0345 protein AOC03_06735 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOC03_06740 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AOC03_06755 ENOG4107QHF type ii secretion system protein e AOC03_06760 ENOG4105CP7 Triose-phosphate isomerase AOC03_06765 ENOG4107EJC Preprotein translocase subunit SecG AOC03_06780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AOC03_06785 ENOG4105CHV Transcription elongation factor NusA AOC03_06790 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AOC03_06795 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AOC03_06800 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOC03_06805 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AOC03_06810 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AOC03_06825 ENOG4105DGW oligopeptidase A AOC03_06835 ENOG4105X23 Endonuclease Exonuclease phosphatase AOC03_06860 ENOG4105BZ1 (ABC) transporter AOC03_06865 ENOG4108TZV Membrane AOC03_06870 ENOG4105WYW fructose-bisphosphate aldolase AOC03_06875 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AOC03_06880 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AOC03_06885 ENOG4105CH7 arginosuccinase AOC03_06895 ENOG4108NEV two component transcriptional regulator, LytTR family AOC03_06920 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AOC03_06945 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AOC03_06950 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AOC03_06955 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AOC03_06960 ENOG4105E33 succinate dehydrogenase AOC03_06965 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AOC03_06970 ENOG4105C7S Dehydrogenase AOC03_06975 ENOG4107QN2 dihydrolipoyl dehydrogenase AOC03_06980 ENOG4105CMV Succinyl-CoA synthetase subunit beta AOC03_06985 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOC03_06990 ENOG4105CMR udp-glucose 4-epimerase AOC03_06995 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOC03_07000 ENOG4107QP8 phosphohexose isomerase AOC03_07005 ENOG4105C6Y Udp-glucose 6-dehydrogenase AOC03_07015 ENOG4105DXN mazG family AOC03_07020 ENOG4105KQC Competence protein AOC03_07025 ENOG4105DJ0 Poly(A) Polymerase AOC03_07030 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOC03_07035 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AOC03_07040 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AOC03_07045 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AOC03_07060 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOC03_07065 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOC03_07070 ENOG4105UBK short-chain dehydrogenase reductase AOC03_07075 ENOG4105KSC Transcriptional regulator, TraR DksA family AOC03_07080 ENOG4105CKI cobalamin synthesis protein AOC03_07085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOC03_07090 ENOG4105BZM domain protein AOC03_07100 ENOG4105EG6 Saccharopine dehydrogenase AOC03_07105 ENOG4105KZX Pterin carbinolamine dehydratase AOC03_07125 ENOG4105C5H ABC transporter AOC03_07135 ENOG4108Z66 YbaK ebsC protein AOC03_07150 ENOG4105CSU acyl-Coa dehydrogenase AOC03_07160 ENOG4105E2X shikimate dehydrogenase AOC03_07170 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AOC03_07185 ENOG4108HED Type II restriction AOC03_07190 ENOG4105HHA aminodeoxychorismate lyase AOC03_07195 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AOC03_07200 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AOC03_07205 ENOG4105C0H protease AOC03_07210 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOC03_07220 ENOG4105C8V SAICAR synthetase AOC03_07235 ENOG4108VX5 3-methyladenine DNA glycosylase AOC03_07255 ENOG4105VDW Csbd family AOC03_07265 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AOC03_07270 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AOC03_07275 ENOG4105C9X ppx gppa phosphatase AOC03_07290 ENOG4105II7 pyrroline-5-carboxylate reductase AOC03_07295 ENOG4108VIA integral membrane protein AOC03_07300 ENOG4105DWF phosphomethylpyrimidine kinase AOC03_07320 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AOC03_07325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOC03_07335 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AOC03_07340 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOC03_07355 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AOC03_07370 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AOC03_07390 ENOG4105CEY Amp-dependent synthetase and ligase AOC03_07395 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOC03_07415 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AOC03_07420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOC03_07425 ENOG4105EUB pirin domain protein AOC03_07430 ENOG4105CBX hi0933 family AOC03_07435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOC03_07470 ENOG4108ETH Formylglycinamide ribotide synthetase AOC03_07490 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOC03_07500 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AOC03_07505 ENOG4108RPX mosc domain containing protein AOC03_07515 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AOC03_07520 ENOG4108DNC Involved in acetate metabolism (By similarity) AOC03_07525 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOC03_07535 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOC03_07545 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AOC03_07550 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOC03_07575 ENOG4105M08 Membrane AOC03_07580 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOC03_07585 ENOG4105VFE sira family AOC03_07600 ENOG4105VCC 30S ribosomal protein S21 AOC03_07615 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOC03_07625 ENOG4105DZ2 Transcriptional regulator AOC03_07630 ENOG4105D38 putrescine abc transporter AOC03_07635 ENOG4105F38 ABC transporter, permease AOC03_07640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOC03_07650 ENOG4107XDR Lactoylglutathione lyase AOC03_07660 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AOC03_07670 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AOC03_07675 ENOG4105ECY inositol monophosphatase AOC03_07680 ENOG4105D8T Acyltransferase AOC03_07685 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AOC03_07690 ENOG4107QHF type ii secretion system protein e AOC03_07705 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AOC03_07740 ENOG4105D7Q type ii secretion system AOC03_07745 ENOG4108VAU general secretion pathway protein G AOC03_07750 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AOC03_07755 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AOC03_07765 ENOG4105HDD phospholipase AOC03_07830 ENOG4108Z4U Ferredoxin AOC03_07840 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOC03_07855 ENOG4105T2N Domain of unknown function (DUF2382) AOC03_07860 ENOG4105CHU acetyl-coa acetyltransferase AOC03_07865 ENOG4105D6E homoserine dehydrogenase AOC03_07870 ENOG4105T95 Thiol disulfide interChange protein AOC03_07875 ENOG4105CKW Inner membrane protein yedI AOC03_07880 ENOG4107QQB Ribonuclease E AOC03_07885 ENOG4105EI2 Pseudouridine synthase AOC03_07895 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AOC03_07905 ENOG4106RE7 Cytochrome AOC03_07920 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AOC03_07925 ENOG41090R7 Ferric uptake AOC03_07930 ENOG4105CZX twitching motility protein AOC03_07935 ENOG4105CZX twitching motility protein AOC03_07940 ENOG4105DFA alanine racemase domain protein AOC03_07945 ENOG4105C37 (CBS) domain AOC03_07955 ENOG4105IPI Membrane AOC03_07965 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AOC03_07970 ENOG4108UPT UPF0178 protein AOC03_07975 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOC03_07980 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOC03_08010 ENOG4105CN1 protease AOC03_08015 ENOG4108YZY peptidylprolyl cis-trans isomerase AOC03_08035 ENOG4108R99 pseudouridine synthase AOC03_08045 ENOG4105E9K Isocitrate dehydrogenase AOC03_08065 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AOC03_08070 ENOG4105D6U Sodium Glutamate Symporter AOC03_08075 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AOC03_08085 ENOG4108JEH abc transporter atp-binding protein AOC03_08090 ENOG4106PMH Extracellular solute-binding protein family 3 AOC03_08095 ENOG4106PMH Extracellular solute-binding protein family 3 AOC03_08100 ENOG4106TNF Periplasmic binding protein AOC03_08125 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AOC03_08145 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AOC03_08150 ENOG4107RP9 extracellular solute-binding protein, family 3 AOC03_08155 ENOG4105EAD ABC transporter AOC03_08160 ENOG4105DRP amino acid AbC transporter AOC03_08165 ENOG4105CDA abc transporter atp-binding protein AOC03_08170 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase AOC03_08175 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AOC03_08185 ENOG4105HF0 Membrane AOC03_08190 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOC03_08195 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AOC03_08200 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AOC03_08220 ENOG4105CCT upf0313 protein AOC03_08230 ENOG4105FKN transcriptional regulator, AsnC family AOC03_08235 ENOG4106KPZ rard protein AOC03_08240 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AOC03_08245 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AOC03_08250 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AOC03_08255 ENOG4105C8Y Acetylornithine aminotransferase AOC03_08270 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AOC03_08275 ENOG4105C3F Signal peptidase i AOC03_08285 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AOC03_08290 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AOC03_08300 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AOC03_08310 ENOG4108WHA ompa motb domain protein AOC03_08320 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AOC03_08330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOC03_08335 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOC03_08340 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOC03_08350 ENOG4105C6T cysteine synthase AOC03_08360 ENOG4105E39 Enoyl-CoA hydratase AOC03_08365 ENOG4105C2C drug resistance transporter, Bcr CflA AOC03_08370 ENOG4105CBS Chea signal transduction histidine kinase AOC03_08375 ENOG4107YTP response regulator receiver protein AOC03_08390 ENOG4105CE9 30S ribosomal protein S2 AOC03_08395 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AOC03_08400 ENOG4105E4C Lytic transglycosylase catalytic AOC03_08415 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOC03_08425 ENOG4105CPC Aldo Keto reductase AOC03_08430 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AOC03_08445 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOC03_08455 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOC03_08460 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOC03_08470 ENOG4105CQB FAD linked oxidase domain protein AOC03_08475 ENOG4108JQ1 Dehydrogenase AOC03_08480 ENOG4105VT2 5-hydroxyisourate hydrolase AOC03_08485 ENOG4105C72 UPF0176 protein AOC03_08495 ENOG4105DWV Homoserine O-trans-acetylase AOC03_08500 ENOG4105DWV Homoserine O-trans-acetylase AOC03_08505 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOC03_08515 ENOG4105CHR reductase AOC03_08520 ENOG4105C2M dna polymerase I AOC03_08535 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AOC03_08575 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AOC03_08580 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AOC03_08585 ENOG4105W1Y Transcriptional regulator AOC03_08590 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AOC03_08595 ENOG4105C3M thioredoxin reductase AOC03_08600 ENOG4105CNU cell division protein FtsK AOC03_08610 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AOC03_08615 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AOC03_08650 ENOG4107QSS Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) AOC03_08660 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AOC03_08665 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOC03_08675 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AOC03_08690 ENOG4105C3R Methionine synthase AOC03_08705 ENOG4105BZG amino acid carrier protein AOC03_08745 ENOG4105CVR type I restriction-modification system AOC03_08820 ENOG4105MPD Cytochrome AOC03_08825 ENOG4105DA5 (ABC) transporter AOC03_08830 ENOG4105E3A (ABC) transporter AOC03_08835 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AOC03_08845 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AOC03_08870 ENOG4108Z12 YiaAB two helix domain-containing protein AOC03_08875 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AOC03_08885 ENOG4105K9H YciI-like protein AOC03_08890 ENOG4107835 probably involved in intracellular septation (By similarity) AOC03_08895 ENOG4105DB7 PHP domain protein AOC03_08905 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AOC03_08935 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOC03_08940 ENOG4107RDB Major Facilitator AOC03_08945 ENOG4108UUM single-stranded DNA-binding protein AOC03_08950 ENOG4108X73 DNA- binding protein AOC03_08965 ENOG4105GVR general secretion pathway protein D AOC03_08980 ENOG4105F8V Hydrolase, tatD family AOC03_08985 ENOG4105CUZ uba thif-type nad fad binding protein AOC03_08990 ENOG4105BZU Histidine kinase AOC03_08995 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AOC03_09000 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOC03_09010 ENOG4105BZU Histidine kinase AOC03_09020 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOC03_09030 ENOG4105F8C transglutaminase domain-containing protein AOC03_09055 ENOG4105DKK Benzoate AOC03_09095 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AOC03_09100 ENOG410633P Hydantoin racemase AOC03_09115 ENOG4105HF0 Membrane AOC03_09120 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) AOC03_09125 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AOC03_09150 ENOG410841Q phosphoesterase PA-phosphatase related protein AOC03_09170 ENOG4105K6H D-cysteine desulfhydrase AOC03_09175 ENOG4105FFC UPF0187 protein AOC03_09190 ENOG4105XJC Two component transcriptional regulator (Winged helix family AOC03_09195 ENOG4105DHQ Histidine kinase AOC03_09200 ENOG4105CH6 catalase AOC03_09205 ENOG4105CZN Potassium uptake protein AOC03_09210 ENOG4107ZYR domain protein AOC03_09235 ENOG4105CC0 LysR family Transcriptional regulator AOC03_09240 ENOG4105EUB pirin domain protein AOC03_09245 ENOG4105CHF Glutathione S-transferase AOC03_09275 ENOG4108D32 Methyltransferase AOC03_09285 ENOG4108HPI phosphatidate Cytidylyltransferase AOC03_09290 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AOC03_09300 ENOG4105E8V Alpha Beta Hydrolase Fold protein AOC03_09305 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOC03_09310 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOC03_09315 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOC03_09320 ENOG410838B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AOC03_09325 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOC03_09340 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOC03_09345 ENOG4105E0C molybdate abc transporter AOC03_09355 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AOC03_09370 ENOG4108V5Q transglutaminase-like protein AOC03_09375 ENOG4108YYQ gCN5-related N-acetyltransferase AOC03_09395 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AOC03_09410 ENOG4105EAB amino acid AbC transporter AOC03_09415 ENOG4105E5Q amino acid AbC transporter AOC03_09420 ENOG4105CDA abc transporter atp-binding protein AOC03_09425 ENOG4105S0E allantoin catabolism protein AOC03_09430 ENOG4108Z2U ureidoglycolate hydrolase AOC03_09440 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AOC03_09450 ENOG41084YZ Hydrolase AOC03_09465 ENOG4107ENK receptor AOC03_09475 ENOG4108IPW abc transporter atp-binding protein AOC03_09480 ENOG4105CM4 permease protein AOC03_09485 ENOG4105DHS permease protein AOC03_09505 ENOG4105SG9 biopolymer transport protein, ExbD AOC03_09520 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOC03_09525 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOC03_09545 ENOG4105D3Y Na H antiporter AOC03_09555 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOC03_09570 ENOG4105GNX MltA-interacting MipA family protein AOC03_09575 ENOG4107ZXI Rhomboid family AOC03_09590 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AOC03_09610 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AOC03_09615 ENOG4107QP3 malate synthase g AOC03_09635 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AOC03_09640 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOC03_09655 ENOG4105C59 p-type ATPase AOC03_09660 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AOC03_09665 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AOC03_09670 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AOC03_09685 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AOC03_09695 ENOG4105CDH Citrulline--aspartate ligase AOC03_09715 ENOG4107RET Isocitrate lyase AOC03_09725 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOC03_09730 ENOG4105CXB phosphoribosylaminoimidazole synthetase AOC03_09735 ENOG4105C02 permease AOC03_09750 ENOG4108RMU ferritin dps family protein AOC03_09760 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AOC03_09765 ENOG4105CV1 Transketolase (EC 2.2.1.1) AOC03_09775 ENOG4108YYC ycei family AOC03_09795 ENOG4105C26 Dehydrogenase AOC03_09800 ENOG4107QUV Domain protein AOC03_09805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOC03_10055 ENOG4105ED4 portal protein AOC03_10080 ENOG4107S78 Band 7 protein AOC03_10085 ENOG4105PV3 Inner membrane protein yqiJ AOC03_10100 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AOC03_10120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOC03_10140 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AOC03_10150 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOC03_10180 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOC03_10185 ENOG4105EN6 Membrane AOC03_10195 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOC03_10200 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AOC03_10210 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AOC03_10215 ENOG4107QIJ Aconitate hydratase 2 AOC03_10220 ENOG4105KAF membrAne AOC03_10230 ENOG4105CGU Enoyl-CoA hydratase AOC03_10235 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AOC03_10245 ENOG4105DAX Pfam:DUF2983 AOC03_10260 ENOG4105KME endoribonuclease L-psp AOC03_10280 ENOG4108HRK Histidine kinase AOC03_10285 ENOG4105DY9 regulatoR AOC03_10320 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOC03_10325 ENOG4105D64 Mechanosensitive ion channel AOC03_10330 ENOG4107QN2 dihydrolipoyl dehydrogenase AOC03_10335 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOC03_10345 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AOC03_10350 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AOC03_10360 ENOG4105C58 cytochrome c oxidase accessory protein ccog AOC03_10365 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) AOC03_10380 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i AOC03_10395 ENOG4105D60 lipoprotein releasing system transmembrane protein AOC03_10400 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOC03_10410 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AOC03_10415 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AOC03_10430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOC03_10435 ENOG4105CSH Transporter AOC03_10440 ENOG4107RZC phospholipase d AOC03_10445 ENOG4105C28 cystathionine AOC03_10450 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AOC03_10455 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AOC03_10460 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AOC03_10465 ENOG4107IFA Lipase (EC 3.1.1.3) AOC03_10470 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AOC03_10480 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AOC03_10485 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AOC03_10510 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AOC03_10525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOC03_10535 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AOC03_10540 ENOG4108TSD Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOC03_10545 ENOG4107QKW extracellular solute-binding protein family 1 AOC03_10550 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component AOC03_10555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOC03_10560 ENOG4106371 Methyltransferase AOC03_10575 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOC03_10580 ENOG4106KPZ rard protein AOC03_10595 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOC03_10605 ENOG4105D9P serine threonine protein kinase AOC03_10630 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) AOC03_10635 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOC03_10640 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AOC03_10645 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOC03_10650 ENOG4105KNE Phosphatidate cytidylyltransferase AOC03_10655 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOC03_10660 ENOG4105DZP Membrane-associated zinc metalloprotease AOC03_10665 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AOC03_10670 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOC03_10675 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AOC03_10680 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AOC03_10685 ENOG4105C8J )-transporter AOC03_10690 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AOC03_10710 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AOC03_10715 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AOC03_10720 ENOG4105EHM Aminoglycoside phosphotransferase AOC03_10725 ENOG4108S0S Nucleotidyl transferase AOC03_10730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOC03_10735 ENOG4105C4M (Ubiquinol oxidase) subunit I AOC03_10750 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) AOC03_10765 ENOG4105MA0 exported protein AOC03_10775 ENOG4105QNF Outer membrane lipoprotein AOC03_10785 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOC03_10790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOC03_10795 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOC03_10800 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AOC03_10810 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AOC03_10815 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOC03_10825 ENOG4108Z6B deaminase AOC03_10830 ENOG4105CAT Cytidine monophosphate kinase AOC03_10835 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AOC03_10840 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AOC03_10850 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AOC03_10865 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AOC03_10870 ENOG4105K4T epimerase AOC03_10875 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AOC03_10880 ENOG4108JA2 transcriptioN-repair coupling factor AOC03_10895 ENOG4108ZIT Ferredoxin, 2FE-2S AOC03_10910 ENOG4108Z4V iron-sulfur cluster assembly AOC03_10915 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AOC03_10925 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AOC03_10935 ENOG4105K70 DNA-binding protein AOC03_10940 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AOC03_10945 ENOG4105DC1 bifunctional purine biosynthesis protein purh AOC03_10950 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AOC03_10960 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AOC03_10970 ENOG4105BZ4 penicillin-binding protein AOC03_10985 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOC03_10990 ENOG4105VUT cytoplasmic protein AOC03_11000 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AOC03_11005 ENOG4105CFH Aspartokinase AOC03_11010 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOC03_11030 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AOC03_11035 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOC03_11080 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AOC03_11085 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AOC03_11090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AOC03_11105 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AOC03_11110 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AOC03_11125 ENOG4107KET secretion protein, HlyD family AOC03_11135 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AOC03_11185 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AOC03_11190 ENOG4107QSN dihydrolipoamide acetyltransferase AOC03_11195 ENOG4105EIF outer membrane protein W AOC03_11205 ENOG4105EYW Ion transport protein AOC03_11220 ENOG4105DAN ATP-dependent protease AOC03_11225 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AOC03_11230 ENOG4107QJE Chromosome Partitioning Protein AOC03_11235 ENOG4105FA0 parb-like partition protein AOC03_11240 ENOG4105BZ1 (ABC) transporter AOC03_11245 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AOC03_11250 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AOC03_11255 ENOG4107QRG dna polymerase iii AOC03_11270 ENOG4105CHR reductase AOC03_11290 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AOC03_11295 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AOC03_11310 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOC03_11320 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) AOC03_11325 ENOG4105ETT transcriptional Regulator, LysR family AOC03_11330 ENOG4108JPW Aminotransferase AOC03_11335 ENOG4105E32 cytoplasmic protein AOC03_11340 ENOG4105C26 Dehydrogenase AOC03_11345 ENOG4105DFD Na H antiporter AOC03_11350 ENOG4105CJP fad dependent oxidoreductase AOC03_11355 ENOG4105CQB FAD linked oxidase domain protein AOC03_11360 ENOG4105BZW Glycerate kinase AOC03_11365 ENOG4105CGF Aromatic amino acid aminotransferase AOC03_11375 ENOG4108YZN class I peptide chain release factor AOC03_11445 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AOC03_11455 ENOG4105ECI YeeC-like protein AOC03_11460 ENOG4105F6A helicase AOC03_11490 ENOG4105C0D helicase AOC03_11565 ENOG4108JNI Alpha beta hydrolase AOC03_11570 ENOG4105VQD rieske 2fe-2S domain-containing protein AOC03_11585 ENOG4105IKQ hydratase AOC03_11600 ENOG4105EA8 2-Nitropropane dioxygenase AOC03_11605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOC03_11610 ENOG4105FUY alpha subunit AOC03_11625 ENOG4108SC4 )-transporter AOC03_11645 ENOG4105CC0 LysR family Transcriptional regulator AOC03_11650 ENOG4108VBZ doxx family AOC03_11655 ENOG4108YYH Nadph-dependent fmn reductase AOC03_11670 ENOG4105C2I pirin domain protein AOC03_11675 ENOG4105EUB pirin domain protein AOC03_11695 ENOG4105ETT transcriptional Regulator, LysR family AOC03_11700 ENOG4108JPW Aminotransferase AOC03_11705 ENOG4105E32 cytoplasmic protein AOC03_11710 ENOG4105CQB FAD linked oxidase domain protein AOC03_11725 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AOC03_11730 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AOC03_11735 ENOG4105C6K Malic enzyme AOC03_11760 ENOG4108WBT adenosyltransferase AOC03_11765 ENOG4105C8N cysteinyl-tRNA synthetase AOC03_11770 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AOC03_11775 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AOC03_11780 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AOC03_11805 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AOC03_11810 ENOG4108I6A alcohol dehydrogenase AOC03_11815 ENOG4108WUH Transcriptional regulator, TetR family AOC03_11830 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOC03_11875 ENOG4105CEY Amp-dependent synthetase and ligase AOC03_12150 ENOG4105XUP Phage derived protein Gp49-like (DUF891) AOC03_12165 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOC03_12180 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOC03_12215 ENOG4107QMH DNA methylase AOC03_12245 ENOG4107QMH DNA methylase AOC03_12270 ENOG4105EKX Restriction modification system DNA (Specificity AOC03_12295 ENOG4105DRR Transcriptional regulator, GntR family AOC03_12300 ENOG4105DIA mandelate racemase muconate lactonizing AOC03_12305 ENOG4105CXK mandelate racemase muconate lactonizing AOC03_12345 ENOG4105CHR reductase AOC03_12355 ENOG4108Z40 Transcriptional regulator AOC03_12360 ENOG4108RYK Nad-dependent epimerase dehydratase AOC03_12365 ENOG4105DJY efflux transporter, rnd family, mfp subunit AOC03_12375 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOC03_12390 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AOC03_12405 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)