locus-tag	class	description
E9099_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E9099_00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E9099_00030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E9099_00040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E9099_00060	COG0456	acetyltransferase
E9099_00070	COG0640	Transcriptional regulator
E9099_00100	COG0702	epimerase
E9099_00110	COG0415	Belongs to the DNA photolyase family
E9099_00115	COG3046	protein related to deoxyribodipyrimidine photolyase
E9099_00120	COG0415	Belongs to the DNA photolyase family
E9099_00135	COG0302	gtp cyclohydrolase
E9099_00150	COG0386	Belongs to the glutathione peroxidase family
E9099_00165	COG0415	Belongs to the DNA photolyase family
E9099_00295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E9099_00315	COG0514	ATP-dependent DNA helicase (RecQ)
E9099_00320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E9099_00330	COG1678	Uncharacterized ACR, COG1678
E9099_00335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E9099_00350	COG0124	histidyl-tRNA synthetase
E9099_00370	COG0359	binds to the 23S rRNA
E9099_00375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E9099_00380	COG0360	Binds together with S18 to 16S ribosomal RNA
E9099_00385	COG3279	Response regulator of the LytR AlgR family
E9099_00390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E9099_00410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E9099_00415	COG1505	serine-type exopeptidase activity
E9099_00425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E9099_00430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E9099_00460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E9099_00475	COG0488	(ABC) transporter
E9099_00490	COG0336	Belongs to the RNA methyltransferase TrmD family
E9099_00495	COG0335	large ribosomal subunit rRNA binding
E9099_00525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E9099_00590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E9099_00595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E9099_00600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E9099_00605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E9099_00610	COG0561	phosphatase activity
E9099_00615	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E9099_00635	COG0305	Participates in initiation and elongation during chromosome replication
E9099_00640	COG0825	malonyl-CoA metabolic process
E9099_00655	COG0343	queuine tRNA-ribosyltransferase activity
E9099_00660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E9099_00665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E9099_00680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E9099_00685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E9099_00690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E9099_00715	COG1233	COG1233 Phytoene dehydrogenase and related
E9099_00735	COG1770	oligopeptidase
E9099_00740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E9099_00755	COG1049	propionate catabolic process, 2-methylcitrate cycle
E9099_00760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E9099_00760	COG2755	lipolytic protein G-D-S-L family
E9099_00770	COG0714	Associated with various cellular activities
E9099_00775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E9099_00785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E9099_00820	COG1028	Short-chain dehydrogenase reductase Sdr
E9099_00975	COG2076	Multidrug Resistance protein
E9099_01005	COG0516	GMP reductase activity
E9099_01005	COG0517	IMP dehydrogenase activity
E9099_01060	COG0167	dihydroorotate dehydrogenase activity
E9099_01065	COG2195	Cleaves the N-terminal amino acid of tripeptides
E9099_01110	COG1862	Preprotein translocase
E9099_01120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E9099_01130	COG1132	(ABC) transporter
E9099_01145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E9099_01155	COG2318	DinB family
E9099_01160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E9099_01170	COG0514	ATP-dependent DNA helicase (RecQ)
E9099_01175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E9099_01175	COG0517	IMP dehydrogenase activity
E9099_01180	COG0805	protein transport
E9099_01190	COG1137	ATPase activity
E9099_01195	COG1253	flavin adenine dinucleotide binding
E9099_01215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E9099_01245	COG1216	Glycosyl transferase, family 2
E9099_01255	COG1045	serine acetyltransferase
E9099_01280	COG2089	acid synthase
E9099_01310	COG0463	Glycosyl transferase, family 2
E9099_01320	COG1696	Membrane protein involved in D-alanine export
E9099_01325	COG0463	Glycosyl transferase, family 2
E9099_01330	COG2226	methyltransferase
E9099_01335	COG1216	Glycosyl transferase, family 2
E9099_01345	COG1216	Glycosyl transferase, family 2
E9099_01360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E9099_01370	COG0489	protein tyrosine kinase activity
E9099_01380	COG0488	(ABC) transporter
E9099_01405	COG0653	protein targeting
E9099_01420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E9099_01430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E9099_01435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E9099_01540	COG1595	DNA-templated transcription, initiation
E9099_01550	COG1703	isobutyryl-CoA mutase activity
E9099_01585	COG0463	Glycosyl transferase, family 2
E9099_01600	COG0671	phosphoesterase, PA-phosphatase related
E9099_01610	COG0534	Mate efflux family protein
E9099_01630	COG0482	sulfurtransferase activity
E9099_01635	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E9099_01645	COG0706	membrane insertase activity
E9099_01650	COG0504	CTP synthase activity
E9099_01665	COG3530	Putative quorum-sensing-regulated virulence factor
E9099_01680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E9099_01680	COG0519	Catalyzes the synthesis of GMP from XMP
E9099_01690	COG0076	glutamate decarboxylase activity
E9099_01695	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
E9099_01715	COG2720	vancomycin resistance protein
E9099_01720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E9099_01725	COG0154	amidase activity
E9099_01730	COG0552	protein localization to endoplasmic reticulum
E9099_01740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E9099_01745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E9099_01750	COG1546	Belongs to the CinA family
E9099_01750	COG1058	Belongs to the CinA family
E9099_01760	COG0179	Fumarylacetoacetate (FAA) hydrolase
E9099_01780	COG0508	dehydrogenase complex catalyzes the overall conversion of
E9099_01790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E9099_01795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E9099_01810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E9099_01815	COG0326	Molecular chaperone. Has ATPase activity
E9099_01820	COG0784	Response regulator, receiver
E9099_01820	COG2205	protein histidine kinase activity
E9099_01825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E9099_01890	COG3220	belongs to the UPF0276 family
E9099_01965	COG3177	Filamentation induced by cAMP protein fic
E9099_02005	COG2936	dipeptidyl-peptidase activity
E9099_02035	COG2258	MOSC domain
E9099_02045	COG1289	transmembrane transporter activity
E9099_02050	COG2010	Cytochrome c
E9099_02065	COG0513	Belongs to the DEAD box helicase family
E9099_02090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E9099_02100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E9099_02120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E9099_02135	COG3956	TIGRFAM MazG family protein
E9099_02145	COG0242	peptide deformylase activity
E9099_02150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E9099_02155	COG2171	N-acyltransferase activity
E9099_02170	COG0463	Glycosyl transferase, family 2
E9099_02225	COG0617	tRNA 3'-terminal CCA addition
E9099_02235	COG1612	heme a metabolic process
E9099_02250	COG1131	(ABC) transporter
E9099_02275	COG0556	nucleotide-excision repair
E9099_02290	COG0045	succinate-CoA ligase (ADP-forming) activity
E9099_02295	COG0019	diaminopimelate decarboxylase activity
E9099_02300	COG5002	protein histidine kinase activity
E9099_02300	COG5001	Diguanylate cyclase
E9099_02300	COG3447	MASE1 domain protein
E9099_02305	COG2204	response regulator
E9099_02330	COG2326	polyphosphate kinase activity
E9099_02350	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E9099_02350	COG3264	Mechanosensitive ion channel
E9099_02355	COG1668	transmembrane transport
E9099_02360	COG4152	abc transporter atp-binding protein
E9099_02365	COG0484	heat shock protein binding
E9099_02370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E9099_02375	COG2353	YceI-like domain
E9099_02380	COG1733	regulation of RNA biosynthetic process
E9099_02405	COG1073	alpha beta
E9099_02435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E9099_02465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E9099_02470	COG0085	RNA polymerase activity
E9099_02475	COG0222	ribosome binding
E9099_02480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E9099_02485	COG0081	regulation of translation
E9099_02490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E9099_02535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E9099_02540	COG4974	Belongs to the 'phage' integrase family
E9099_02545	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E9099_02550	COG0366	Alpha amylase catalytic
E9099_02560	COG1960	acyl-CoA dehydrogenase activity
E9099_02570	COG1115	amino acid carrier protein
E9099_02575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E9099_02670	COG5002	protein histidine kinase activity
E9099_02715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E9099_02725	COG4206	TonB-dependent receptor
E9099_02725	COG1629	transport
E9099_02730	COG3279	Response regulator of the LytR AlgR family
E9099_02735	COG3275	phosphorelay sensor kinase activity
E9099_02765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E9099_02770	COG0563	adenylate kinase activity
E9099_02775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E9099_02780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E9099_02825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E9099_02825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E9099_02830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E9099_02840	COG1215	transferase activity, transferring glycosyl groups
E9099_02895	COG2274	protein secretion by the type I secretion system
E9099_02910	COG0525	valine-tRNA ligase activity
E9099_02925	COG0436	Aminotransferase
E9099_02930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E9099_02935	COG1595	DNA-templated transcription, initiation
E9099_02945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E9099_02965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E9099_02970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E9099_02975	COG2205	protein histidine kinase activity
E9099_02975	COG0784	Response regulator, receiver
E9099_02980	COG1663	tetraacyldisaccharide 4'-kinase activity
E9099_02985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E9099_03010	COG3844	kynureninase activity
E9099_03015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E9099_03035	COG1028	Short-chain dehydrogenase reductase Sdr
E9099_03040	COG0662	Cupin 2, conserved barrel domain protein
E9099_03065	COG2072	flavoprotein involved in K transport
E9099_03095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E9099_03125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E9099_03160	COG1160	GTP binding
E9099_03175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E9099_03225	COG0745	RESPONSE REGULATOR receiver
E9099_03270	COG0708	Exodeoxyribonuclease III
E9099_03275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E9099_03285	COG1250	3-hydroxyacyl-CoA dehydrogenase
E9099_03285	COG1024	Enoyl-CoA hydratase
E9099_03310	COG4716	Myosin-crossreactive antigen
E9099_03330	COG4716	Myosin-crossreactive antigen
E9099_03335	COG3174	membrane
E9099_03360	COG4716	Myosin-crossreactive antigen
E9099_03450	COG0488	(ABC) transporter
E9099_03460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E9099_03460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E9099_03480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E9099_03490	COG1754	DNA topoisomerase type I activity
E9099_03490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E9099_03495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E9099_03520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E9099_03525	COG0459	protein refolding
E9099_03545	COG0138	bifunctional purine biosynthesis protein purh
E9099_03550	COG1077	Cell shape determining protein MreB Mrl
E9099_03570	COG0772	Belongs to the SEDS family
E9099_03590	COG1428	Deoxynucleoside kinase
E9099_03600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E9099_03615	COG0022	dehydrogenase e1 component
E9099_03615	COG0508	dehydrogenase complex catalyzes the overall conversion of
E9099_03625	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E9099_03635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E9099_03640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E9099_03650	COG4447	cellulose binding
E9099_03650	COG5520	Belongs to the glycosyl hydrolase 30 family
E9099_03650	COG3291	Pkd domain containing protein
E9099_03670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E9099_03690	COG1028	Short-chain dehydrogenase reductase Sdr
E9099_03695	COG1187	pseudouridine synthase activity
E9099_03720	COG1309	transcriptional regulator
E9099_03725	COG2081	HI0933 family
E9099_03730	COG0584	glycerophosphoryl diester phosphodiesterase
E9099_03785	COG1899	peptidyl-lysine modification to peptidyl-hypusine
E9099_03790	COG0010	Belongs to the arginase family
E9099_03840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E9099_03845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E9099_03850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E9099_03870	COG1490	D-aminoacyl-tRNA deacylase activity
E9099_03875	COG1162	GTPase activity
E9099_03885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E9099_03890	COG0287	Prephenate dehydrogenase
E9099_03900	COG1605	Chorismate mutase
E9099_03900	COG0077	Prephenate dehydratase
E9099_03925	COG1045	serine acetyltransferase
E9099_03930	COG0492	ferredoxin-NADP+ reductase activity
E9099_03935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E9099_03935	COG1648	precorrin-2 dehydrogenase activity
E9099_03945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E9099_03955	COG0175	sulfate reduction
E9099_03960	COG0175	sulfate reduction
E9099_03970	COG1959	2 iron, 2 sulfur cluster binding
E9099_03975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E9099_03985	COG1410	methionine synthase
E9099_03985	COG0646	methionine synthase
E9099_04000	COG0527	aspartate kinase activity
E9099_04000	COG0460	homoserine dehydrogenase
E9099_04020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E9099_04025	COG0357	Ribosomal RNA small subunit methyltransferase G
E9099_04030	COG3239	Fatty acid desaturase
E9099_04055	COG0569	domain protein
E9099_04060	COG2226	methyltransferase
E9099_04085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E9099_04095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E9099_04100	COG1185	polyribonucleotide nucleotidyltransferase activity
E9099_04115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E9099_04120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E9099_04125	COG1215	transferase activity, transferring glycosyl groups
E9099_04150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E9099_04170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E9099_04180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E9099_04185	COG2239	Acts as a magnesium transporter
E9099_04195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E9099_04205	COG1610	YqeY-like protein
E9099_04210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E9099_04225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E9099_04230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E9099_04235	COG0772	Belongs to the SEDS family
E9099_04240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E9099_04245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E9099_04250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E9099_04265	COG0275	rRNA processing
E9099_04270	COG2001	Belongs to the MraZ family
E9099_04275	COG2267	carboxylic ester hydrolase activity
E9099_04280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E9099_04415	COG1028	Short-chain dehydrogenase reductase Sdr
E9099_04430	COG0300	oxidoreductase activity
E9099_04435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E9099_04440	COG0793	Belongs to the peptidase S41A family
E9099_04445	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E9099_04455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E9099_04460	COG0791	NLP P60 protein
E9099_04465	COG0658	competence protein
E9099_04465	COG2333	competence protein COMEC
E9099_04475	COG3104	oligopeptide transport
E9099_04475	COG3104	oligopeptide transport
E9099_04480	COG3104	oligopeptide transport
E9099_04505	COG1253	flavin adenine dinucleotide binding
E9099_04530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E9099_04540	COG0590	tRNA wobble adenosine to inosine editing
E9099_04545	COG0519	Catalyzes the synthesis of GMP from XMP
E9099_04590	COG4206	TonB-dependent receptor
E9099_04590	COG1629	transport
E9099_04620	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E9099_04635	COG0463	Glycosyl transferase, family 2
E9099_04640	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E9099_04650	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
E9099_04665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E9099_04695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E9099_04715	COG1215	transferase activity, transferring glycosyl groups
E9099_04725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E9099_04730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E9099_04735	COG0052	Belongs to the universal ribosomal protein uS2 family
E9099_04740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E9099_04745	COG0528	UMP kinase activity
E9099_04750	COG0233	cytoplasmic translational termination
E9099_04770	COG0017	Asparaginyl-tRNA synthetase
E9099_04775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E9099_04805	COG0811	peptide transport
E9099_04815	COG0252	asparaginase activity
E9099_04820	COG0084	hydrolase, TatD family'
E9099_04855	COG2197	response regulator
E9099_04860	COG0508	dehydrogenase complex catalyzes the overall conversion of
E9099_04870	COG0567	Dehydrogenase, E1 component
E9099_04885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E9099_04890	COG4263	nitrous-oxide reductase activity
E9099_04935	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
E9099_04940	COG1959	2 iron, 2 sulfur cluster binding
E9099_04970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E9099_04975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E9099_05015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E9099_05025	COG1404	Belongs to the peptidase S8 family
E9099_05030	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E9099_05035	COG1629	transport
E9099_05035	COG4206	TonB-dependent receptor
E9099_05065	COG1360	Flagellar Motor Protein
E9099_05085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E9099_05085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E9099_05100	COG2095	MarC family integral membrane protein
E9099_05115	COG3409	Peptidoglycan-binding domain 1 protein
E9099_05115	COG0793	Belongs to the peptidase S41A family
E9099_05130	COG1482	cell wall glycoprotein biosynthetic process
E9099_05145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E9099_05150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E9099_05155	COG0193	aminoacyl-tRNA hydrolase activity
E9099_05170	COG0196	riboflavin kinase activity
E9099_05180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E9099_05200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E9099_05205	COG2239	Acts as a magnesium transporter
E9099_05215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E9099_05220	COG0346	lactoylglutathione lyase activity
E9099_05245	COG0527	aspartate kinase activity
E9099_05255	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E9099_05275	COG5002	protein histidine kinase activity
E9099_05275	COG2198	Histidine kinase
E9099_05275	COG0784	Response regulator, receiver
E9099_05285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E9099_05305	COG0495	leucyl-tRNA aminoacylation
E9099_05310	COG2177	Part of the ABC transporter FtsEX involved in
E9099_05320	COG1968	undecaprenyl-diphosphatase activity
E9099_05325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E9099_05340	COG0519	Catalyzes the synthesis of GMP from XMP
E9099_05345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E9099_05355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E9099_05360	COG3852	Histidine kinase
E9099_05375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E9099_05390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E9099_05415	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
E9099_05425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E9099_05440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E9099_05445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E9099_05455	COG0612	Peptidase, M16
E9099_05460	COG0612	Peptidase, M16
E9099_05470	COG2217	Heavy metal translocating P-type atpase
E9099_05475	COG4974	Belongs to the 'phage' integrase family
E9099_05545	COG2205	protein histidine kinase activity
E9099_05545	COG0784	Response regulator, receiver
E9099_05575	COG0776	regulation of translation
E9099_05580	COG1530	ribonuclease E activity
E9099_05600	COG0667	Aldo Keto reductase
E9099_05605	COG1360	Flagellar Motor Protein
E9099_05610	COG0708	Exodeoxyribonuclease III
E9099_05635	COG0423	glycine-tRNA ligase activity
E9099_05655	COG1040	competence protein
E9099_05665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E9099_05675	COG3279	Response regulator of the LytR AlgR family
E9099_05680	COG3275	phosphorelay sensor kinase activity
E9099_05695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E9099_05730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E9099_05735	COG1053	succinate dehydrogenase
E9099_05755	COG0006	proline dipeptidase activity
E9099_05775	COG0427	acetyl-CoA hydrolase
E9099_05945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E9099_05980	COG0527	aspartate kinase activity
E9099_06015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E9099_06020	COG0316	Belongs to the HesB IscA family
E9099_06025	COG0719	Fe-S assembly protein
E9099_06035	COG0396	ATPase activity
E9099_06040	COG0719	Fe-S assembly protein
E9099_06050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E9099_06060	COG2166	iron-sulfur cluster assembly
E9099_06065	COG2151	metal-sulfur cluster biosynthetic enzyme
E9099_06085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E9099_06130	COG0784	Response regulator, receiver
E9099_06135	COG4251	negative regulation of phosphorylation
E9099_06185	COG0629	single-stranded DNA binding
E9099_06210	COG0516	GMP reductase activity
E9099_06210	COG0517	IMP dehydrogenase activity
E9099_06225	COG2885	chlorophyll binding
E9099_06255	COG3590	peptidase
E9099_06275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E9099_06285	COG0750	zinc metalloprotease
E9099_06290	COG1999	signal sequence binding
E9099_06320	COG4771	TonB-dependent receptor
E9099_06330	COG0803	Belongs to the bacterial solute-binding protein 9 family
E9099_06335	COG1121	(ABC) transporter
E9099_06340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E9099_06345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E9099_06350	COG0484	heat shock protein binding
E9099_06370	COG1418	mRNA catabolic process
E9099_06390	COG1917	Cupin 2, conserved barrel domain protein
E9099_06390	COG2207	Transcriptional regulator
E9099_06410	COG1024	Enoyl-CoA hydratase
E9099_06415	COG5000	phosphorelay sensor kinase activity
E9099_06430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E9099_06445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E9099_06455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E9099_06470	COG0408	coproporphyrinogen oxidase activity
E9099_06480	COG3012	SEC-C Motif Domain Protein
E9099_06485	COG0556	nucleotide-excision repair
E9099_06490	COG0113	porphobilinogen synthase activity
E9099_06505	COG1253	flavin adenine dinucleotide binding
E9099_06510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E9099_06530	COG3227	Zinc metalloprotease (Elastase)
E9099_06540	COG4172	Belongs to the ABC transporter superfamily
E9099_06555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E9099_06560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E9099_06570	COG1774	PSP1 C-terminal conserved region
E9099_06580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E9099_06610	COG0180	Tryptophanyl-tRNA synthetase
E9099_06615	COG0758	DNA mediated transformation
E9099_06615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E9099_06625	COG1607	acyl-coa hydrolase
E9099_06630	COG0739	heme binding
E9099_06645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E9099_06655	COG0756	dUTP diphosphatase activity
E9099_06670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E9099_06675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E9099_06680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E9099_06685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E9099_06690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E9099_06695	COG0356	it plays a direct role in the translocation of protons across the membrane
E9099_06745	COG0859	PFAM glycosyl transferase family 9
E9099_06755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E9099_06820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E9099_06825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E9099_06830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E9099_06830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E9099_06835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E9099_06920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E9099_06925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E9099_06935	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E9099_06970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E9099_06980	COG1388	LysM domain
E9099_06980	COG1705	Flagellar rod assembly protein muramidase FlgJ
E9099_06985	COG0126	phosphoglycerate kinase activity
E9099_07000	COG1597	lipid kinase activity
E9099_07020	COG0445	tRNA wobble uridine modification
E9099_07025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E9099_07040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E9099_07050	COG0330	HflC and HflK could
E9099_07085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E9099_07120	COG0393	Putative heavy-metal-binding
E9099_07125	COG0557	exoribonuclease II activity
E9099_07130	COG0698	ribose 5-phosphate isomerase
E9099_07140	COG2153	protein acetylation
E9099_07150	COG0793	Belongs to the peptidase S41A family
E9099_07155	COG0594	ribonuclease P activity
E9099_07175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E9099_07180	COG0659	secondary active sulfate transmembrane transporter activity
E9099_07190	COG3263	regulation of cellular component size
E9099_07215	COG0481	GTPase activity
E9099_07250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E9099_07265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E9099_07270	COG0346	lactoylglutathione lyase activity
E9099_07285	COG0129	dihydroxy-acid dehydratase activity
E9099_07290	COG0028	Belongs to the TPP enzyme family
E9099_07295	COG0440	acetolactate synthase activity
E9099_07300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E9099_07305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E9099_07310	COG1012	belongs to the aldehyde dehydrogenase family
E9099_07320	COG0137	argininosuccinate synthase activity
E9099_07325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E9099_07335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E9099_07345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E9099_07355	COG0165	Argininosuccinate lyase
E9099_07365	COG0070	glutamate synthase
E9099_07365	COG0069	glutamate synthase activity
E9099_07365	COG0067	glutamate synthase
E9099_07380	COG0004	ammonium transporteR
E9099_07385	COG0473	3-isopropylmalate dehydrogenase activity
E9099_07390	COG0066	3-isopropylmalate dehydratase activity
E9099_07395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E9099_07400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E9099_07420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E9099_07430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E9099_07435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E9099_07440	COG0511	ligase activity, forming carbon-carbon bonds
E9099_07445	COG0439	Biotin carboxylase
E9099_07470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E9099_07485	COG3541	Predicted nucleotidyltransferase
E9099_07490	COG0617	tRNA 3'-terminal CCA addition
E9099_07515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E9099_07530	COG1690	Belongs to the RtcB family
E9099_07575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E9099_07590	COG1505	serine-type exopeptidase activity
E9099_07595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E9099_07600	COG1970	mechanosensitive ion channel activity
E9099_07610	COG1435	thymidine kinase activity
E9099_07625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E9099_07635	COG1573	uracil-dna glycosylase
E9099_07650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E9099_07650	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E9099_07665	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E9099_07670	COG0720	synthase
E9099_07720	COG0210	DNA helicase
E9099_07735	COG1074	ATP-dependent DNA helicase activity
E9099_07750	COG0351	phosphomethylpyrimidine kinase
E9099_07750	COG0352	thiamine-phosphate diphosphorylase activity
E9099_07755	COG3341	Caulimovirus viroplasmin
E9099_07755	COG0328	RNA-DNA hybrid ribonuclease activity
E9099_07760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E9099_07765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E9099_07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E9099_07775	COG0571	ribonuclease III activity
E9099_07785	COG0469	pyruvate kinase activity
E9099_07795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E9099_07805	COG4953	penicillin-binding protein 1C
E9099_07815	COG1012	belongs to the aldehyde dehydrogenase family
E9099_07820	COG2885	chlorophyll binding
E9099_07820	COG3047	cAMP biosynthetic process
E9099_07840	COG4221	oxidoreductase activity
E9099_07845	COG4989	oxidoreductase activity
E9099_07850	COG0714	Associated with various cellular activities
E9099_07865	COG2304	oxidoreductase activity
E9099_07870	COG2304	oxidoreductase activity
E9099_07915	COG0659	secondary active sulfate transmembrane transporter activity
E9099_07920	COG0288	reversible hydration of carbon dioxide
E9099_07935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E9099_07945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E9099_07960	COG1309	transcriptional regulator
E9099_07990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E9099_08020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E9099_08030	COG1652	LysM domain
E9099_08035	COG1733	regulation of RNA biosynthetic process
E9099_08130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E9099_08135	COG0194	GDP metabolic process
E9099_08140	COG1561	YicC-like family, N-terminal region
E9099_08175	COG0626	cystathionine gamma-synthase activity
E9099_08185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E9099_08195	COG1381	Involved in DNA repair and RecF pathway recombination
E9099_08225	COG4206	TonB-dependent receptor
E9099_08245	COG3655	Transcriptional regulator
E9099_08250	COG2268	Band 7 protein
E9099_08285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E9099_08300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E9099_08305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E9099_08320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E9099_08330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E9099_08345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E9099_08350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E9099_08360	COG0189	ligase activity
E9099_08365	COG0189	ligase activity
E9099_08365	COG4067	protein conserved in archaea
E9099_08370	COG0322	excinuclease ABC activity
E9099_08375	COG1752	Esterase of the alpha-beta hydrolase superfamily
E9099_08380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E9099_08385	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E9099_08395	COG3483	tryptophan 2,3-dioxygenase activity
E9099_08405	COG0166	Belongs to the GPI family
E9099_08470	COG4977	sequence-specific DNA binding
E9099_08475	COG0123	including yeast histone deacetylase and acetoin utilization protein
E9099_08495	COG2885	chlorophyll binding
E9099_08505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E9099_08505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E9099_08510	COG1619	proteins homologs of microcin C7 resistance protein MccF
E9099_08515	COG0792	nuclease activity
E9099_08560	COG1522	sequence-specific DNA binding
E9099_08570	COG2363	Small membrane protein
E9099_08575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E9099_08590	COG0463	Glycosyl transferase, family 2
E9099_08595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E9099_08610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E9099_08625	COG0745	RESPONSE REGULATOR receiver
E9099_08630	COG5002	protein histidine kinase activity
E9099_08635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E9099_08640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E9099_08655	COG0489	protein tyrosine kinase activity
E9099_08665	COG0492	ferredoxin-NADP+ reductase activity
E9099_08670	COG0633	Ferredoxin
E9099_08685	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E9099_08690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E9099_08695	COG0228	four-way junction DNA binding
E9099_08715	COG3118	belongs to the thioredoxin family
E9099_08720	COG0740	serine-type endopeptidase activity
E9099_08795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E9099_08800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E9099_08825	COG0784	Response regulator, receiver
E9099_08835	COG4251	negative regulation of phosphorylation
E9099_08845	COG4251	negative regulation of phosphorylation
E9099_08855	COG3279	Response regulator of the LytR AlgR family
E9099_08860	COG2340	Cysteine-rich secretory protein family
E9099_08870	COG2197	response regulator
E9099_08880	COG0531	amino acid
E9099_08930	COG0745	RESPONSE REGULATOR receiver
E9099_08940	COG1482	cell wall glycoprotein biosynthetic process
E9099_08945	COG2824	Alkylphosphonate utilization operon protein PhnA
E9099_08965	COG2234	aminopeptidase activity
E9099_08985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E9099_08995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E9099_09000	COG4206	TonB-dependent receptor
E9099_09000	COG1629	transport
E9099_09015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E9099_09020	COG1554	hydrolase, family 65, central catalytic
E9099_09030	COG1501	Belongs to the glycosyl hydrolase 31 family
E9099_09035	COG0366	Alpha amylase catalytic
E9099_09045	COG1032	radical SAM domain protein
E9099_09050	COG2852	Protein conserved in bacteria
E9099_09085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E9099_09085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E9099_09095	COG1408	metallophosphoesterase
E9099_09100	COG3118	belongs to the thioredoxin family
E9099_09125	COG0779	Required for maturation of 30S ribosomal subunits
E9099_09130	COG0195	Participates in both transcription termination and antitermination
E9099_09130	COG2251	uridine kinase activity
E9099_09135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E9099_09150	COG0437	4 iron, 4 sulfur cluster binding
E9099_09180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E9099_09205	COG0632	four-way junction helicase activity
E9099_09215	COG0509	glycine decarboxylation via glycine cleavage system
E9099_09240	COG0109	protoheme IX farnesyltransferase activity
E9099_09245	COG1845	cytochrome c oxidase, subunit III
E9099_09265	COG1999	signal sequence binding
E9099_09270	COG2322	membrane
E9099_09280	COG1136	(ABC) transporter
E9099_09285	COG0577	efflux transmembrane transporter activity
E9099_09285	COG1136	(ABC) transporter
E9099_09290	COG0577	efflux transmembrane transporter activity
E9099_09290	COG1136	(ABC) transporter
E9099_09295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E9099_09305	COG1214	PFAM Peptidase M22, glycoprotease
E9099_09310	COG0668	transmembrane transport
E9099_09335	COG3275	phosphorelay sensor kinase activity
E9099_09340	COG3279	Response regulator of the LytR AlgR family
E9099_09345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E9099_09365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E9099_09375	COG0544	peptidyl-prolyl cis-trans isomerase activity
E9099_09385	COG0596	Alpha beta hydrolase
E9099_09390	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E9099_09400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E9099_09410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E9099_09430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E9099_09435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E9099_09440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E9099_09455	COG1428	Deoxynucleoside kinase
E9099_09485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E9099_09515	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E9099_09520	COG1914	H( )-stimulated, divalent metal cation uptake system
E9099_09540	COG1629	transport
E9099_09540	COG4206	TonB-dependent receptor
E9099_09555	COG2271	Major facilitator Superfamily
E9099_09570	COG0800	Aldolase
E9099_09590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E9099_09600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E9099_09605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E9099_09610	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E9099_09615	COG0358	DNA primase activity
E9099_09625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E9099_09640	COG1012	belongs to the aldehyde dehydrogenase family
E9099_09655	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E9099_09660	COG1805	sodium ion transport
E9099_09665	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E9099_09670	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E9099_09675	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E9099_09695	COG1477	protein flavinylation
E9099_09700	COG2363	Small membrane protein
E9099_09705	COG2226	methyltransferase
E9099_09720	COG0427	acetyl-CoA hydrolase
E9099_09730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E9099_09735	COG0501	Belongs to the peptidase M48B family
E9099_09740	COG1876	peptidase activity
E9099_09745	COG2153	protein acetylation
E9099_09770	COG3340	Belongs to the peptidase S51 family
E9099_09810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E9099_09815	COG1388	LysM domain
E9099_09815	COG0791	NLP P60 protein
E9099_09820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E9099_09840	COG4682	membrane
E9099_09855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E9099_09860	COG0321	lipoyl(octanoyl) transferase activity
E9099_09875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E9099_09940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E9099_09945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E9099_09960	COG0295	cytidine deaminase activity
E9099_09965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E9099_09970	COG0508	dehydrogenase complex catalyzes the overall conversion of
E9099_10010	COG0018	arginyl-trna synthetase
E9099_10050	COG1629	transport
E9099_10050	COG4206	TonB-dependent receptor
E9099_10060	COG1595	DNA-templated transcription, initiation
E9099_10080	COG1012	belongs to the aldehyde dehydrogenase family
E9099_10085	COG1301	dicarboxylic acid transport
E9099_10130	COG1127	ABC transporter
E9099_10135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E9099_10140	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
E9099_10150	COG0688	phosphatidylethanolamine metabolic process
E9099_10155	COG4589	Belongs to the CDS family
E9099_10165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E9099_10170	COG0799	negative regulation of ribosome biogenesis
E9099_10185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E9099_10210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E9099_10210	COG3153	acetyltransferase
E9099_10220	COG0659	secondary active sulfate transmembrane transporter activity
E9099_10225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E9099_10235	COG1181	Belongs to the D-alanine--D-alanine ligase family
E9099_10240	COG0515	serine threonine protein kinase
E9099_10240	COG2815	serine threonine protein kinase
E9099_10245	COG0564	pseudouridine synthase activity
E9099_10250	COG3022	response to hydroperoxide
E9099_10305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E9099_10465	COG2197	response regulator
E9099_10505	COG3179	chitinase
E9099_10515	COG0513	Belongs to the DEAD box helicase family
E9099_10525	COG4628	conserved protein (DUF2132)
E9099_10530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E9099_10535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E9099_10555	COG0159	tryptophan synthase activity
E9099_10565	COG2827	Endonuclease containing a URI domain
E9099_10570	COG0133	tryptophan synthase activity
E9099_10575	COG0135	phosphoribosylanthranilate isomerase activity
E9099_10580	COG0134	indole-3-glycerol-phosphate synthase activity
E9099_10585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E9099_10590	COG0512	Glutamine amidotransferase of anthranilate synthase
E9099_10595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E9099_10600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E9099_10615	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E9099_10615	COG5479	isomerase activity
E9099_10625	COG2207	Transcriptional regulator
E9099_10655	COG2949	membrane
E9099_10695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E9099_10735	COG2244	polysaccharide biosynthetic process
E9099_10745	COG0438	transferase activity, transferring glycosyl groups
E9099_10755	COG1216	Glycosyl transferase, family 2
E9099_10765	COG2884	Cell division ATP-binding protein ftsE
E9099_10780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E9099_10790	COG0500	methyltransferase
E9099_10810	COG3876	Protein conserved in bacteria
E9099_10815	COG0577	efflux transmembrane transporter activity
E9099_10825	COG1047	Peptidyl-prolyl cis-trans
E9099_10840	COG2003	Belongs to the UPF0758 family
E9099_10860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E9099_10885	COG1629	transport
E9099_10885	COG4206	TonB-dependent receptor
E9099_10895	COG4206	TonB-dependent receptor
E9099_10895	COG1629	transport
E9099_10905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E9099_10910	COG0049	tRNA binding
E9099_10915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E9099_10920	COG0051	transcription antitermination factor activity, RNA binding
E9099_10925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E9099_10930	COG0088	Forms part of the polypeptide exit tunnel
E9099_10935	COG0089	rRNA binding
E9099_10940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E9099_10945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E9099_10950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E9099_10955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E9099_10960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E9099_10965	COG0255	Belongs to the universal ribosomal protein uL29 family
E9099_10970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E9099_10975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E9099_10980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E9099_10985	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E9099_10990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E9099_10995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E9099_11000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E9099_11005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E9099_11010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E9099_11015	COG1841	ribosomal large subunit assembly
E9099_11020	COG0200	Binds to the 23S rRNA
E9099_11030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E9099_11035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E9099_11040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E9099_11045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E9099_11050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E9099_11055	COG0202	RNA polymerase activity
E9099_11060	COG0203	ribosomal protein L17
E9099_11065	COG0505	Belongs to the CarA family
E9099_11070	COG0148	phosphopyruvate hydratase activity
E9099_11115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E9099_11155	COG2801	Transposase and inactivated derivatives
E9099_11190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E9099_11195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E9099_11210	COG1187	pseudouridine synthase activity
E9099_11220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E9099_11220	COG0662	Cupin 2, conserved barrel domain protein
E9099_11235	COG0433	COG0433 Predicted ATPase
E9099_11240	COG0602	queuosine metabolic process
E9099_11250	COG0367	asparagine synthase
E9099_11255	COG2205	protein histidine kinase activity
E9099_11255	COG0784	Response regulator, receiver
E9099_11260	COG0187	DNA topoisomerase II activity
E9099_11280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E9099_11290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E9099_11295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E9099_11300	COG0215	cysteine-tRNA ligase activity
E9099_11305	COG0302	gtp cyclohydrolase
E9099_11330	COG0442	prolyl-tRNA aminoacylation
E9099_11340	COG0268	Binds directly to 16S ribosomal RNA
E9099_11400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E9099_11405	COG1960	acyl-CoA dehydrogenase activity
E9099_11415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E9099_11425	COG0811	peptide transport
E9099_11430	COG0848	biopolymer transport protein
E9099_11440	COG0285	dihydrofolate synthase activity
E9099_11450	COG0443	Heat shock 70 kDa protein
E9099_11480	COG0101	tRNA pseudouridine synthase activity
E9099_11485	COG1132	(ABC) transporter
E9099_11505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E9099_11525	COG0149	triose-phosphate isomerase activity
E9099_11530	COG2264	protein methyltransferase activity
E9099_11570	COG0668	transmembrane transport
E9099_11575	COG2356	endonuclease I
E9099_11595	COG0174	glutamine synthetase
E9099_11605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E9099_11630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E9099_11640	COG0284	orotidine-5'-phosphate decarboxylase activity
E9099_11645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E9099_11660	COG0788	formyltetrahydrofolate deformylase activity
E9099_11665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E9099_11665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E9099_11665	COG1703	isobutyryl-CoA mutase activity
E9099_11675	COG1595	DNA-templated transcription, initiation
E9099_11690	COG1522	sequence-specific DNA binding
E9099_11695	COG4977	sequence-specific DNA binding
E9099_11705	COG2814	Major facilitator Superfamily
E9099_11745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E9099_11780	COG0501	Belongs to the peptidase M48B family
E9099_11785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E9099_11800	COG2827	Endonuclease containing a URI domain
E9099_11805	COG1228	amidohydrolase
E9099_11810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E9099_11825	COG2195	Cleaves the N-terminal amino acid of tripeptides
E9099_11845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E9099_11845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E9099_11880	COG2217	Heavy metal translocating P-type atpase
E9099_11910	COG2801	Transposase and inactivated derivatives
E9099_11940	COG0564	pseudouridine synthase activity
E9099_11950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E9099_11965	COG0105	UTP biosynthetic process
E9099_11970	COG1278	Cold shock
E9099_11975	COG1278	Cold shock
E9099_11990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E9099_12000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E9099_12015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E9099_12025	COG0705	Rhomboid family
E9099_12050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E9099_12060	COG1475	DNA binding
E9099_12065	COG1192	Involved in chromosome partitioning
E9099_12070	COG3420	alginic acid biosynthetic process
E9099_12085	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E9099_12085	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E9099_12095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E9099_12115	COG1012	belongs to the aldehyde dehydrogenase family
E9099_12140	COG0492	ferredoxin-NADP+ reductase activity
E9099_12205	COG0783	Belongs to the Dps family
E9099_12325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E9099_12380	COG3275	phosphorelay sensor kinase activity
E9099_12390	COG3279	Response regulator of the LytR AlgR family
E9099_12415	COG4206	TonB-dependent receptor
E9099_12425	COG1595	DNA-templated transcription, initiation
E9099_12490	COG1960	acyl-CoA dehydrogenase activity
E9099_12495	COG0183	Belongs to the thiolase family
E9099_12500	COG1024	Enoyl-CoA hydratase
E9099_12500	COG1250	3-hydroxyacyl-CoA dehydrogenase
E9099_12510	COG1022	Amp-dependent synthetase and ligase
E9099_12530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E9099_12530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E9099_12535	COG1595	DNA-templated transcription, initiation
E9099_12625	COG1595	DNA-templated transcription, initiation
E9099_12630	COG1132	(ABC) transporter
E9099_12635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E9099_12640	COG0463	Glycosyl transferase, family 2
E9099_12650	COG0254	rRNA binding
E9099_12675	COG0747	negative chemotaxis
E9099_12680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E9099_12710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E9099_12725	COG1607	acyl-coa hydrolase
E9099_12735	COG1322	Protein conserved in bacteria
E9099_12740	COG1120	ATPase activity
E9099_12745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E9099_12800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E9099_12820	COG0484	heat shock protein binding
E9099_12835	COG0798	PFAM Bile acid sodium symporter
E9099_12845	COG0640	Transcriptional regulator
E9099_12880	COG0598	Magnesium transport protein CorA
E9099_12895	COG0424	maF-like protein
E9099_12940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E9099_12940	COG1333	cytochrome c biogenesis protein
E9099_12955	COG1970	mechanosensitive ion channel activity
E9099_12965	COG0626	cystathionine gamma-synthase activity
E9099_12970	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E9099_12975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E9099_13045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E9099_13075	COG3609	addiction module antidote protein, CC2985 family
E9099_13085	COG0583	DNA-binding transcription factor activity
E9099_13090	COG1280	lysine exporter protein (LysE YggA)
E9099_13175	COG0488	(ABC) transporter
E9099_13180	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E9099_13195	COG0072	phenylalanine-tRNA ligase activity
E9099_13195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E9099_13310	COG1231	oxidoreductase activity
E9099_13315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E9099_13335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E9099_13370	COG2972	Histidine kinase
E9099_13370	COG0745	RESPONSE REGULATOR receiver
E9099_13375	COG3279	Response regulator of the LytR AlgR family
E9099_13390	COG0069	glutamate synthase activity
E9099_13405	COG0009	L-threonylcarbamoyladenylate synthase
E9099_13440	COG0693	protein deglycase activity
E9099_13460	COG0022	dehydrogenase e1 component
E9099_13470	COG1611	Belongs to the LOG family
E9099_13495	COG0405	Gamma-glutamyltransferase
E9099_13510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E9099_13530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E9099_13535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E9099_13540	COG1396	sequence-specific DNA binding
E9099_13550	COG3550	peptidyl-serine autophosphorylation
E9099_13565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E9099_13575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E9099_13590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E9099_13635	COG0515	serine threonine protein kinase
E9099_13685	COG2202	Pas domain
E9099_13685	COG2205	protein histidine kinase activity
E9099_13720	COG3604	Transcriptional regulator
E9099_13755	COG3852	Histidine kinase
E9099_13760	COG2204	response regulator
E9099_13765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E9099_13795	COG0542	response to heat
E9099_13895	COG3179	chitinase
E9099_14000	COG0791	NLP P60 protein
E9099_14060	COG0348	domain, Protein
E9099_14090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E9099_14105	COG0589	response to stress
E9099_14110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E9099_14120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E9099_14130	COG4251	negative regulation of phosphorylation
E9099_14150	COG0730	response to heat
E9099_14155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E9099_14155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E9099_14165	COG3118	belongs to the thioredoxin family
E9099_14175	COG1271	oxidase subunit
E9099_14180	COG1294	oxidase, subunit
E9099_14205	COG1131	(ABC) transporter
E9099_14210	COG1131	(ABC) transporter
E9099_14220	COG0842	Transport permease protein
E9099_14225	COG0842	Transport permease protein
E9099_14225	COG1129	ABC transporter
E9099_14235	COG1335	isochorismatase
E9099_14240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E9099_14255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E9099_14270	COG2391	methyltransferase activity
E9099_14290	COG4771	TonB-dependent receptor
E9099_14415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E9099_14445	COG0592	DNA-directed DNA polymerase activity
E9099_14475	COG1702	phosphate starvation-inducible protein PhoH
E9099_14480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E9099_14495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E9099_14530	COG1115	amino acid carrier protein
E9099_14540	COG2207	Transcriptional regulator
E9099_14545	COG1012	belongs to the aldehyde dehydrogenase family
E9099_14570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E9099_14580	COG5002	protein histidine kinase activity
E9099_14585	COG0745	RESPONSE REGULATOR receiver
E9099_14600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E9099_14605	COG2852	Protein conserved in bacteria
E9099_14610	COG2852	Protein conserved in bacteria
E9099_14640	COG4585	Histidine kinase
E9099_14650	COG1525	nuclease
E9099_14675	COG1858	cytochrome C peroxidase
E9099_14685	COG2095	MarC family integral membrane protein
E9099_14690	COG2814	Major facilitator Superfamily
E9099_14725	COG1132	(ABC) transporter
E9099_14730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E9099_14735	COG0439	Biotin carboxylase
E9099_14740	COG0511	ligase activity, forming carbon-carbon bonds
E9099_14750	COG2339	peptidase activity
E9099_14755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E9099_14765	COG1363	Peptidase, m42
E9099_14775	COG1272	protein, Hemolysin III
E9099_14785	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E9099_14790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E9099_14815	COG0116	Belongs to the methyltransferase superfamily
E9099_14815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E9099_14830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E9099_14835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E9099_14860	COG1104	cysteine desulfurase activity
E9099_14905	COG1418	mRNA catabolic process
E9099_14910	COG4585	Histidine kinase
E9099_14915	COG3290	protein histidine kinase activity
E9099_14920	COG4974	Belongs to the 'phage' integrase family
E9099_14930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E9099_14935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E9099_14940	COG1252	NADH dehydrogenase
E9099_14955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E9099_14960	COG0297	glycogen (starch) synthase activity
E9099_14965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E9099_14970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E9099_14985	COG2270	Major facilitator Superfamily
E9099_15010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E9099_15015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E9099_15040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E9099_15065	COG1169	isochorismate synthase
E9099_15070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E9099_15080	COG2996	Protein conserved in bacteria
E9099_15100	COG1575	Belongs to the MenA family. Type 1 subfamily
E9099_15105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E9099_15110	COG4221	oxidoreductase activity
E9099_15115	COG4948	Mandelate Racemase Muconate Lactonizing
E9099_15120	COG1266	CAAX protease self-immunity
E9099_15130	COG4206	TonB-dependent receptor
E9099_15130	COG1629	transport
E9099_15140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E9099_15145	COG0431	NADPH-dependent FMN reductase
E9099_15150	COG1846	Transcriptional regulator
E9099_15155	COG1741	Belongs to the pirin family
E9099_15165	COG0488	(ABC) transporter
E9099_15180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E9099_15245	COG1228	amidohydrolase
E9099_15270	COG1393	Belongs to the ArsC family
E9099_15275	COG1393	Belongs to the ArsC family
E9099_15290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E9099_15290	COG2885	chlorophyll binding
E9099_15295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E9099_15310	COG0156	8-amino-7-oxononanoate synthase activity
E9099_15365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E9099_15375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E9099_15380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E9099_15385	COG0217	transcriptional regulatory protein
E9099_15395	COG2154	pterin-4-alpha-carbinolamine dehydratase
E9099_15405	COG2066	Belongs to the glutaminase family
E9099_15410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E9099_15420	COG2855	membrane
E9099_15425	COG0583	DNA-binding transcription factor activity
E9099_15430	COG0702	epimerase
E9099_15595	COG1119	ATPase activity
E9099_15680	COG1607	acyl-coa hydrolase
E9099_15755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E9099_15760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E9099_15770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E9099_15775	COG1629	transport
E9099_15775	COG4206	TonB-dependent receptor
E9099_15780	COG0012	GTP binding
E9099_15800	COG3291	Pkd domain containing protein
E9099_15830	COG0861	Integral membrane protein TerC family
E9099_15850	COG1522	sequence-specific DNA binding
E9099_15860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E9099_15865	COG0506	proline dehydrogenase activity
E9099_15890	COG2204	response regulator
E9099_15895	COG1078	dGTPase activity
E9099_15900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E9099_15905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E9099_15905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E9099_15910	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E9099_15915	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E9099_15920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E9099_15930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E9099_15935	COG0612	Peptidase, M16
E9099_15940	COG1028	Short-chain dehydrogenase reductase Sdr
E9099_15960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E9099_15965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E9099_15970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E9099_15975	COG0131	Imidazoleglycerol-phosphate dehydratase
E9099_15985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E9099_15995	COG0107	imidazoleglycerol-phosphate synthase activity
E9099_16000	COG0140	phosphoribosyl-ATP diphosphatase activity
E9099_16000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E9099_16015	COG0101	tRNA pseudouridine synthase activity
E9099_16020	COG0783	Belongs to the Dps family
E9099_16025	COG0668	transmembrane transport
E9099_16070	COG1278	Cold shock
E9099_16075	COG1278	Cold shock
E9099_16095	COG0513	Belongs to the DEAD box helicase family
E9099_16110	COG1012	belongs to the aldehyde dehydrogenase family
E9099_16125	COG1278	Cold shock
E9099_16130	COG1278	Cold shock
E9099_16135	COG1278	Cold shock
E9099_16145	COG1979	alcohol dehydrogenase
E9099_16150	COG2130	NADP-dependent
E9099_16155	COG1764	response to oxidative stress
E9099_16170	COG1309	transcriptional regulator
E9099_16200	COG1172	Belongs to the binding-protein-dependent transport system permease family
E9099_16205	COG0246	Mannitol dehydrogenase
E9099_16215	COG4585	Histidine kinase
E9099_16220	COG2197	response regulator
E9099_16235	COG1902	pentaerythritol trinitrate reductase activity
E9099_16240	COG1764	response to oxidative stress
E9099_16245	COG1064	alcohol dehydrogenase
E9099_16260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E9099_16265	COG1136	(ABC) transporter
E9099_16270	COG0577	efflux transmembrane transporter activity
E9099_16270	COG1136	(ABC) transporter
E9099_16275	COG2814	Major facilitator Superfamily
E9099_16280	COG0385	Bile acid
E9099_16285	COG3275	phosphorelay sensor kinase activity
E9099_16290	COG3279	Response regulator of the LytR AlgR family
E9099_16325	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E9099_16335	COG0778	Nitroreductase
E9099_16365	COG2249	NAD(P)H dehydrogenase (quinone) activity
E9099_16375	COG1733	regulation of RNA biosynthetic process
E9099_16380	COG0778	Nitroreductase
E9099_16400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E9099_16450	COG2985	domain, Protein
E9099_16465	COG2095	MarC family integral membrane protein
E9099_16475	COG1278	Cold shock
E9099_16500	COG3047	cAMP biosynthetic process
E9099_16500	COG2885	chlorophyll binding
E9099_16510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E9099_16515	COG2217	Heavy metal translocating P-type atpase
E9099_16530	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E9099_16540	COG0352	thiamine-phosphate diphosphorylase activity
E9099_16580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E9099_16605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E9099_16610	COG2022	thiamine diphosphate biosynthetic process
E9099_16615	COG0352	thiamine-phosphate diphosphorylase activity
E9099_16630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E9099_16760	COG0612	Peptidase, M16
E9099_16815	COG1187	pseudouridine synthase activity
E9099_16820	COG0668	transmembrane transport
E9099_16850	COG0022	dehydrogenase e1 component
E9099_16870	COG0813	purine-nucleoside phosphorylase activity
E9099_16885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E9099_16895	COG1288	antiporter activity
E9099_16930	COG0101	tRNA pseudouridine synthase activity
E9099_17050	COG2249	NAD(P)H dehydrogenase (quinone) activity
E9099_17145	COG1193	negative regulation of DNA recombination
E9099_17150	COG2827	Endonuclease containing a URI domain
E9099_17160	COG3011	Protein conserved in bacteria
E9099_17175	COG2897	thiosulfate sulfurtransferase activity
E9099_17180	COG1301	dicarboxylic acid transport
E9099_17190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E9099_17205	COG0247	lactate metabolic process
E9099_17205	COG0277	FAD linked oxidase domain protein
E9099_17215	COG0438	transferase activity, transferring glycosyl groups
E9099_17220	COG1472	Belongs to the glycosyl hydrolase 3 family
E9099_17230	COG0560	Phosphoserine phosphatase
E9099_17230	COG3830	Belongs to the UPF0237 family
E9099_17240	COG2181	nitrate reductase activity
E9099_17240	COG0247	lactate metabolic process
E9099_17250	COG0247	lactate metabolic process
E9099_17250	COG2181	nitrate reductase activity
E9099_17260	COG0860	N-Acetylmuramoyl-L-alanine amidase
E9099_17270	COG0251	oxidation-reduction process
E9099_17280	COG1803	Methylglyoxal synthase
E9099_17290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E9099_17295	COG0205	6-phosphofructokinase activity
E9099_17305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E9099_17310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E9099_17330	COG0628	permease
E9099_17595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E9099_17615	COG1480	7TM receptor with intracellular HD hydrolase
E9099_17620	COG0183	Belongs to the thiolase family
E9099_17625	COG0791	NLP P60 protein
E9099_17640	COG0542	response to heat
E9099_17650	COG2986	histidine ammonia-lyase
E9099_17655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E9099_17660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E9099_17665	COG0460	homoserine dehydrogenase
E9099_17665	COG0527	aspartate kinase activity
E9099_17670	COG0083	homoserine kinase activity
E9099_17675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E9099_17710	COG0596	Alpha beta hydrolase
E9099_17765	COG2378	regulation of single-species biofilm formation
E9099_17805	COG0302	gtp cyclohydrolase
E9099_17810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E9099_17820	COG1136	(ABC) transporter
E9099_17840	COG4251	negative regulation of phosphorylation
E9099_17860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E9099_17880	COG1234	tRNA 3'-trailer cleavage
E9099_17895	COG1454	alcohol dehydrogenase
E9099_17910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E9099_17915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E9099_17930	COG0742	ribosomal rna small subunit methyltransferase
E9099_17940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E9099_17965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E9099_17990	COG2340	Cysteine-rich secretory protein family
E9099_17995	COG0259	pyridoxamine-phosphate oxidase activity
E9099_18005	COG1234	tRNA 3'-trailer cleavage
E9099_18015	COG0540	Belongs to the ATCase OTCase family
E9099_18030	COG2823	Periplasmic or secreted lipoprotein
E9099_18030	COG1652	LysM domain
E9099_18035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E9099_18045	COG2070	2-Nitropropane dioxygenase
E9099_18050	COG0443	Heat shock 70 kDa protein
E9099_18055	COG1760	l-serine dehydratase
E9099_18060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E9099_18065	COG0564	pseudouridine synthase activity
E9099_18070	COG1012	belongs to the aldehyde dehydrogenase family
E9099_18105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E9099_18115	COG0037	tRNA processing
E9099_18135	COG0513	Belongs to the DEAD box helicase family
E9099_18250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E9099_18280	COG0450	alkyl hydroperoxide reductase
E9099_18285	COG3118	belongs to the thioredoxin family
E9099_18310	COG3291	Pkd domain containing protein
E9099_18315	COG0300	oxidoreductase activity
E9099_18320	COG4628	conserved protein (DUF2132)
E9099_18350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E9099_18360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E9099_18365	COG1674	ftsk spoiiie
E9099_18380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E9099_18380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E9099_18385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E9099_18420	COG0587	DNA-directed DNA polymerase activity
E9099_18425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E9099_18480	COG0535	radical SAM domain protein
E9099_18490	COG0745	RESPONSE REGULATOR receiver
E9099_18545	COG1028	Short-chain dehydrogenase reductase Sdr
E9099_18550	COG0589	response to stress
E9099_18590	COG1136	(ABC) transporter
E9099_18595	COG1136	(ABC) transporter
E9099_18595	COG0577	efflux transmembrane transporter activity
E9099_18630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E9099_18635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E9099_18650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E9099_18660	COG0300	oxidoreductase activity
E9099_18690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E9099_18705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E9099_18710	COG2095	MarC family integral membrane protein
E9099_18725	COG0542	response to heat
E9099_18745	COG0579	oxidoreductase
E9099_18750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E9099_18765	COG0456	acetyltransferase
E9099_18770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E9099_18870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E9099_18875	COG0673	inositol 2-dehydrogenase activity
E9099_18880	COG1250	3-hydroxyacyl-CoA dehydrogenase
E9099_18890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E9099_18900	COG2176	DNA-directed DNA polymerase activity
E9099_18910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E9099_18915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E9099_18930	COG0237	dephospho-CoA kinase activity
E9099_18950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E9099_18955	COG0497	DNA recombination
E9099_18980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E9099_18995	COG0737	Belongs to the 5'-nucleotidase family
E9099_19005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E9099_19015	COG2890	protein-(glutamine-N5) methyltransferase activity
E9099_19030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E9099_19030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E9099_19090	COG1011	Hydrolase
E9099_19110	COG1739	Uncharacterized protein family UPF0029
E9099_19115	COG0824	Thioesterase