locus-tag	class	description
IE4872_CH00001	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IE4872_CH00002	COG0424	maF-like protein
IE4872_CH00003	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE4872_CH00004	COG0237	dephospho-CoA kinase activity
IE4872_CH00005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IE4872_CH00006	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IE4872_CH00007	COG3030	protein affecting phage T7 exclusion by the F plasmid
IE4872_CH00009	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IE4872_CH00012	COG0187	DNA topoisomerase II activity
IE4872_CH00014	COG0179	Fumarylacetoacetate (FAA) hydrolase
IE4872_CH00018	COG0135	phosphoribosylanthranilate isomerase activity
IE4872_CH00019	COG0133	tryptophan synthase activity
IE4872_CH00020	COG0159	tryptophan synthase activity
IE4872_CH00021	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IE4872_CH00022	COG0285	dihydrofolate synthase activity
IE4872_CH00027	COG1074	ATP-dependent DNA helicase activity
IE4872_CH00028	COG2887	Belongs to the helicase family. UvrD subfamily
IE4872_CH00029	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IE4872_CH00030	COG3178	'Phosphotransferase
IE4872_CH00031	COG2205	protein histidine kinase activity
IE4872_CH00032	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IE4872_CH00033	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE4872_CH00034	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE4872_CH00034	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE4872_CH00036	COG0642	Histidine kinase
IE4872_CH00037	COG0745	RESPONSE REGULATOR receiver
IE4872_CH00038	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IE4872_CH00040	COG3145	DNA-N1-methyladenine dioxygenase activity
IE4872_CH00041	COG1072	(Pantothenic acid kinase))
IE4872_CH00042	COG0140	phosphoribosyl-ATP diphosphatase activity
IE4872_CH00043	COG0107	imidazoleglycerol-phosphate synthase activity
IE4872_CH00044	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IE4872_CH00045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IE4872_CH00047	COG0131	Imidazoleglycerol-phosphate dehydratase
IE4872_CH00048	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IE4872_CH00050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IE4872_CH00052	COG2124	cytochrome p450
IE4872_CH00056	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IE4872_CH00058	COG1643	Atp-dependent helicase
IE4872_CH00059	COG2423	ornithine cyclodeaminase activity
IE4872_CH00068	COG0395	ABC-type sugar transport system, permease component
IE4872_CH00069	COG3842	ATPase activity
IE4872_CH00070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IE4872_CH00077	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IE4872_CH00078	COG3668	Plasmid stabilization system
IE4872_CH00080	COG1309	transcriptional regulator
IE4872_CH00081	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_CH00083	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE4872_CH00085	COG1609	Transcriptional regulator
IE4872_CH00087	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE4872_CH00088	COG0673	inositol 2-dehydrogenase activity
IE4872_CH00091	COG0673	inositol 2-dehydrogenase activity
IE4872_CH00092	COG1309	transcriptional regulator
IE4872_CH00094	COG1175	transmembrane transport
IE4872_CH00095	COG0395	ABC-type sugar transport system, permease component
IE4872_CH00097	COG3842	ATPase activity
IE4872_CH00100	COG0246	Mannitol dehydrogenase
IE4872_CH00101	COG1904	glucuronate isomerase
IE4872_CH00102	COG2900	Belongs to the SlyX family
IE4872_CH00103	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_CH00104	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IE4872_CH00108	COG0539	negative regulation of cytoplasmic translation
IE4872_CH00109	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IE4872_CH00113	COG3311	Transcriptional regulator
IE4872_CH00115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IE4872_CH00120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_CH00123	COG3474	cytochrome
IE4872_CH00124	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IE4872_CH00125	COG1605	Chorismate mutase
IE4872_CH00125	COG0077	Prephenate dehydratase
IE4872_CH00128	COG2378	regulation of single-species biofilm formation
IE4872_CH00129	COG2816	NAD+ diphosphatase activity
IE4872_CH00132	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IE4872_CH00133	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IE4872_CH00136	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IE4872_CH00139	COG2814	Major facilitator Superfamily
IE4872_CH00140	COG0779	Required for maturation of 30S ribosomal subunits
IE4872_CH00143	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IE4872_CH00144	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IE4872_CH00145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IE4872_CH00147	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IE4872_CH00148	COG1185	polyribonucleotide nucleotidyltransferase activity
IE4872_CH00150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IE4872_CH00152	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IE4872_CH00162	COG1396	sequence-specific DNA binding
IE4872_CH00166	COG0484	heat shock protein binding
IE4872_CH00167	COG0443	Heat shock 70 kDa protein
IE4872_CH00168	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IE4872_CH00171	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE4872_CH00174	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IE4872_CH00174	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IE4872_CH00175	COG1674	ftsk spoiiie
IE4872_CH00176	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IE4872_CH00177	COG3454	Phosphonate metabolism
IE4872_CH00178	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IE4872_CH00180	COG4778	phosphonate C-P lyase system protein PhnL
IE4872_CH00181	COG4107	phosphonate C-P lyase system protein PhnK
IE4872_CH00182	COG3627	carbon phosphorus lyase activity
IE4872_CH00183	COG3626	phosphonate metabolism
IE4872_CH00184	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IE4872_CH00185	COG3624	Phosphonate C-P lyase system protein PhnG
IE4872_CH00186	COG2188	Transcriptional regulator
IE4872_CH00187	COG0588	phosphoglycerate mutase activity
IE4872_CH00188	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IE4872_CH00189	COG1132	(ABC) transporter
IE4872_CH00190	COG0837	glucose binding
IE4872_CH00191	COG1803	Methylglyoxal synthase
IE4872_CH00192	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IE4872_CH00193	COG4166	transmembrane transport
IE4872_CH00194	COG4174	ABC transporter (Permease)
IE4872_CH00195	COG4239	(ABC) transporter, permease
IE4872_CH00196	COG4172	Belongs to the ABC transporter superfamily
IE4872_CH00199	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IE4872_CH00202	COG0174	glutamine synthetase
IE4872_CH00206	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE4872_CH00213	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IE4872_CH00214	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IE4872_CH00216	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IE4872_CH00217	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IE4872_CH00218	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IE4872_CH00225	COG4964	Belongs to the GSP D family
IE4872_CH00231	COG1280	lysine exporter protein (LysE YggA)
IE4872_CH00233	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IE4872_CH00235	COG0791	NLP P60 protein
IE4872_CH00238	COG0747	negative chemotaxis
IE4872_CH00239	COG0583	DNA-binding transcription factor activity
IE4872_CH00245	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IE4872_CH00255	COG0481	GTPase activity
IE4872_CH00256	COG1396	sequence-specific DNA binding
IE4872_CH00259	COG2137	regulation of response to DNA damage stimulus
IE4872_CH00265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IE4872_CH00267	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IE4872_CH00268	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IE4872_CH00269	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IE4872_CH00270	COG0072	phenylalanine-tRNA ligase activity
IE4872_CH00270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE4872_CH00272	COG3685	Protein conserved in bacteria
IE4872_CH00275	COG0667	Aldo Keto reductase
IE4872_CH00282	COG1570	exodeoxyribonuclease VII activity
IE4872_CH00283	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE4872_CH00284	COG1846	Transcriptional regulator
IE4872_CH00285	COG2309	aminopeptidase activity
IE4872_CH00286	COG0625	glutathione transferase activity
IE4872_CH00290	COG1393	Belongs to the ArsC family
IE4872_CH00292	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE4872_CH00301	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00302	COG0583	DNA-binding transcription factor activity
IE4872_CH00309	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00310	COG0583	DNA-binding transcription factor activity
IE4872_CH00312	COG1063	alcohol dehydrogenase
IE4872_CH00313	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00316	COG0583	DNA-binding transcription factor activity
IE4872_CH00322	COG0667	Aldo Keto reductase
IE4872_CH00323	COG2267	carboxylic ester hydrolase activity
IE4872_CH00324	COG0673	inositol 2-dehydrogenase activity
IE4872_CH00325	COG0745	RESPONSE REGULATOR receiver
IE4872_CH00326	COG0642	Histidine kinase
IE4872_CH00332	COG1505	serine-type exopeptidase activity
IE4872_CH00336	COG0519	Catalyzes the synthesis of GMP from XMP
IE4872_CH00336	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IE4872_CH00344	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IE4872_CH00346	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IE4872_CH00348	COG1968	undecaprenyl-diphosphatase activity
IE4872_CH00352	COG0284	orotidine-5'-phosphate decarboxylase activity
IE4872_CH00354	COG3963	phosphatidate phosphatase activity
IE4872_CH00355	COG0592	DNA-directed DNA polymerase activity
IE4872_CH00356	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IE4872_CH00357	COG3842	ATPase activity
IE4872_CH00359	COG0189	ligase activity
IE4872_CH00361	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IE4872_CH00363	COG1335	isochorismatase
IE4872_CH00365	COG1522	sequence-specific DNA binding
IE4872_CH00367	COG0756	dUTP diphosphatase activity
IE4872_CH00368	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IE4872_CH00371	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE4872_CH00372	COG0640	Transcriptional regulator
IE4872_CH00374	COG0625	glutathione transferase activity
IE4872_CH00375	COG3119	arylsulfatase activity
IE4872_CH00376	COG0583	DNA-binding transcription factor activity
IE4872_CH00377	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IE4872_CH00378	COG1877	trehalose-phosphatase activity
IE4872_CH00381	COG2807	transmembrane transport
IE4872_CH00382	COG2186	Transcriptional regulator
IE4872_CH00384	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IE4872_CH00387	COG2814	Major facilitator Superfamily
IE4872_CH00389	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IE4872_CH00393	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IE4872_CH00394	COG2986	histidine ammonia-lyase
IE4872_CH00395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IE4872_CH00396	COG2226	methyltransferase
IE4872_CH00397	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IE4872_CH00398	COG1024	Enoyl-CoA hydratase
IE4872_CH00399	COG0268	Binds directly to 16S ribosomal RNA
IE4872_CH00400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IE4872_CH00404	COG4774	siderophore transport
IE4872_CH00405	COG0583	DNA-binding transcription factor activity
IE4872_CH00407	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE4872_CH00408	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IE4872_CH00410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IE4872_CH00411	COG1420	regulation of RNA biosynthetic process
IE4872_CH00412	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IE4872_CH00413	COG1957	nucleoside hydrolase
IE4872_CH00414	COG0071	Belongs to the small heat shock protein (HSP20) family
IE4872_CH00416	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IE4872_CH00417	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IE4872_CH00418	COG1396	sequence-specific DNA binding
IE4872_CH00419	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IE4872_CH00421	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IE4872_CH00422	COG1702	phosphate starvation-inducible protein PhoH
IE4872_CH00423	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IE4872_CH00428	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IE4872_CH00430	COG0180	Tryptophanyl-tRNA synthetase
IE4872_CH00436	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IE4872_CH00437	COG0281	malic enzyme
IE4872_CH00437	COG0280	phosphate acetyltransferase
IE4872_CH00440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IE4872_CH00441	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE4872_CH00442	COG0116	Belongs to the methyltransferase superfamily
IE4872_CH00442	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IE4872_CH00446	COG0776	regulation of translation
IE4872_CH00447	COG0616	signal peptide processing
IE4872_CH00447	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IE4872_CH00449	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IE4872_CH00450	COG1137	ATPase activity
IE4872_CH00452	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IE4872_CH00453	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE4872_CH00454	COG0840	transmembrane signaling receptor activity
IE4872_CH00455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_CH00457	COG0840	transmembrane signaling receptor activity
IE4872_CH00458	COG0242	peptide deformylase activity
IE4872_CH00460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IE4872_CH00461	COG0101	tRNA pseudouridine synthase activity
IE4872_CH00463	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE4872_CH00464	COG2171	N-acyltransferase activity
IE4872_CH00468	COG2169	Transcriptional regulator
IE4872_CH00468	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE4872_CH00469	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IE4872_CH00470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IE4872_CH00471	COG5484	DNA packaging
IE4872_CH00473	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IE4872_CH00474	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IE4872_CH00475	COG0706	membrane insertase activity
IE4872_CH00476	COG0594	ribonuclease P activity
IE4872_CH00477	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IE4872_CH00478	COG0840	transmembrane signaling receptor activity
IE4872_CH00479	COG3852	Histidine kinase
IE4872_CH00486	COG3727	T/G mismatch-specific endonuclease activity
IE4872_CH00496	COG3177	Filamentation induced by cAMP protein fic
IE4872_CH00513	COG3550	peptidyl-serine autophosphorylation
IE4872_CH00518	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IE4872_CH00519	COG1309	transcriptional regulator
IE4872_CH00521	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00522	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00523	COG3938	Belongs to the proline racemase family
IE4872_CH00525	COG1940	carbohydrate kinase activity
IE4872_CH00529	COG1072	(Pantothenic acid kinase))
IE4872_CH00530	COG0418	dihydroorotase activity
IE4872_CH00534	COG3174	membrane
IE4872_CH00535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IE4872_CH00537	COG2267	carboxylic ester hydrolase activity
IE4872_CH00541	COG0166	Belongs to the GPI family
IE4872_CH00542	COG0318	PFAM AMP-dependent synthetase and ligase
IE4872_CH00546	COG1174	glycine betaine transport
IE4872_CH00547	COG1125	glycine betaine transport
IE4872_CH00548	COG1174	glycine betaine transport
IE4872_CH00549	COG1732	Glycine betaine
IE4872_CH00551	COG0583	DNA-binding transcription factor activity
IE4872_CH00552	COG3142	Participates in the control of copper homeostasis
IE4872_CH00553	COG1063	alcohol dehydrogenase
IE4872_CH00554	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH00559	COG2721	sulfolactate sulfo-lyase activity
IE4872_CH00561	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00562	COG1376	ErfK ybiS ycfS ynhG family protein
IE4872_CH00566	COG0300	oxidoreductase activity
IE4872_CH00567	COG2226	methyltransferase
IE4872_CH00574	COG2326	polyphosphate kinase activity
IE4872_CH00575	COG5002	protein histidine kinase activity
IE4872_CH00577	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IE4872_CH00578	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IE4872_CH00579	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IE4872_CH00580	COG2967	ApaG domain
IE4872_CH00582	COG0717	Belongs to the dCTP deaminase family
IE4872_CH00584	COG0840	transmembrane signaling receptor activity
IE4872_CH00587	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_CH00594	COG0167	dihydroorotate dehydrogenase activity
IE4872_CH00596	COG1309	transcriptional regulator
IE4872_CH00602	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IE4872_CH00603	COG4566	intracellular signal transduction
IE4872_CH00604	COG4566	intracellular signal transduction
IE4872_CH00616	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE4872_CH00617	COG1959	2 iron, 2 sulfur cluster binding
IE4872_CH00619	COG1201	RNA secondary structure unwinding
IE4872_CH00623	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IE4872_CH00626	COG0730	response to heat
IE4872_CH00630	COG1522	sequence-specific DNA binding
IE4872_CH00633	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_CH00634	COG0697	spore germination
IE4872_CH00636	COG1960	acyl-CoA dehydrogenase activity
IE4872_CH00637	COG0183	Belongs to the thiolase family
IE4872_CH00638	COG1024	Enoyl-CoA hydratase
IE4872_CH00638	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE4872_CH00640	COG1278	Cold shock
IE4872_CH00641	COG2198	Histidine kinase
IE4872_CH00641	COG2205	protein histidine kinase activity
IE4872_CH00641	COG0784	Response regulator, receiver
IE4872_CH00642	COG1970	mechanosensitive ion channel activity
IE4872_CH00645	COG1024	Enoyl-CoA hydratase
IE4872_CH00654	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IE4872_CH00657	COG5328	Belongs to the UPF0262 family
IE4872_CH00658	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE4872_CH00659	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IE4872_CH00660	COG0424	maF-like protein
IE4872_CH00661	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IE4872_CH00663	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00664	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE4872_CH00665	COG1522	sequence-specific DNA binding
IE4872_CH00668	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IE4872_CH00679	COG3395	kinase activity
IE4872_CH00680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IE4872_CH00683	COG0473	3-isopropylmalate dehydrogenase activity
IE4872_CH00685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE4872_CH00686	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE4872_CH00693	COG0601	transmembrane transport
IE4872_CH00694	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_CH00695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00698	COG0454	-acetyltransferase
IE4872_CH00700	COG1522	sequence-specific DNA binding
IE4872_CH00703	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IE4872_CH00713	COG1215	transferase activity, transferring glycosyl groups
IE4872_CH00714	COG0346	lactoylglutathione lyase activity
IE4872_CH00715	COG4251	negative regulation of phosphorylation
IE4872_CH00716	COG0784	Response regulator, receiver
IE4872_CH00717	COG4251	negative regulation of phosphorylation
IE4872_CH00719	COG2197	response regulator
IE4872_CH00721	COG4251	negative regulation of phosphorylation
IE4872_CH00724	COG4651	solute:proton antiporter activity
IE4872_CH00724	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE4872_CH00726	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IE4872_CH00727	COG0840	transmembrane signaling receptor activity
IE4872_CH00730	COG0643	Histidine kinase
IE4872_CH00730	COG2198	Histidine kinase
IE4872_CH00731	COG0835	chemotaxis
IE4872_CH00732	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IE4872_CH00733	COG2201	protein-glutamate methylesterase activity
IE4872_CH00734	COG0745	RESPONSE REGULATOR receiver
IE4872_CH00735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IE4872_CH00737	COG1766	The M ring may be actively involved in energy transduction
IE4872_CH00738	COG2771	luxR family
IE4872_CH00741	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IE4872_CH00742	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IE4872_CH00743	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IE4872_CH00744	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IE4872_CH00745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IE4872_CH00746	COG4786	Flagellar basal body rod
IE4872_CH00747	COG1157	protein secretion by the type III secretion system
IE4872_CH00749	COG1815	bacterial-type flagellum-dependent cell motility
IE4872_CH00750	COG1558	bacterial-type flagellum-dependent cell motility
IE4872_CH00751	COG1677	Flagellar hook-basal body complex protein FliE
IE4872_CH00752	COG4786	Flagellar basal body rod
IE4872_CH00753	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IE4872_CH00754	COG1706	bacterial-type flagellum-dependent cell motility
IE4872_CH00756	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IE4872_CH00758	COG1338	Plays a role in the flagellum-specific transport system
IE4872_CH00762	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IE4872_CH00763	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IE4872_CH00770	COG1749	Flagellar hook protein flgE
IE4872_CH00774	COG5443	negative regulation of bacterial-type flagellum assembly
IE4872_CH00776	COG4794	Type iii secretion
IE4872_CH00777	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IE4872_CH00778	COG1684	flagellar biosynthetic protein fliR
IE4872_CH00785	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IE4872_CH00787	COG0675	Transposase, IS605 OrfB family
IE4872_CH00789	COG1609	Transcriptional regulator
IE4872_CH00790	COG1653	transport
IE4872_CH00791	COG1175	transmembrane transport
IE4872_CH00792	COG0395	ABC-type sugar transport system, permease component
IE4872_CH00793	COG0366	Alpha amylase catalytic
IE4872_CH00794	COG3842	ATPase activity
IE4872_CH00796	COG0129	dihydroxy-acid dehydratase activity
IE4872_CH00797	COG0363	glucosamine-6-phosphate deaminase activity
IE4872_CH00798	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IE4872_CH00799	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00800	COG0174	glutamine synthetase
IE4872_CH00801	COG2081	HI0933 family
IE4872_CH00803	COG0840	transmembrane signaling receptor activity
IE4872_CH00803	COG2972	Histidine kinase
IE4872_CH00804	COG0840	transmembrane signaling receptor activity
IE4872_CH00804	COG2972	Histidine kinase
IE4872_CH00809	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_CH00810	COG2224	Isocitrate lyase
IE4872_CH00813	COG3842	ATPase activity
IE4872_CH00814	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_CH00815	COG1177	transmembrane transport
IE4872_CH00817	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IE4872_CH00818	COG2205	protein histidine kinase activity
IE4872_CH00828	COG1959	2 iron, 2 sulfur cluster binding
IE4872_CH00829	COG0747	negative chemotaxis
IE4872_CH00830	COG0601	transmembrane transport
IE4872_CH00831	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_CH00832	COG0444	Belongs to the ABC transporter superfamily
IE4872_CH00833	COG4608	Belongs to the ABC transporter superfamily
IE4872_CH00834	COG3265	gluconokinase activity
IE4872_CH00836	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH00837	COG1755	Isoprenylcysteine carboxyl methyltransferase
IE4872_CH00840	COG1595	DNA-templated transcription, initiation
IE4872_CH00844	COG0488	(ABC) transporter
IE4872_CH00845	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE4872_CH00859	COG2186	Transcriptional regulator
IE4872_CH00863	COG3634	alkyl hydroperoxide reductase activity
IE4872_CH00873	COG0596	Alpha beta hydrolase
IE4872_CH00874	COG1764	response to oxidative stress
IE4872_CH00875	COG0596	Alpha beta hydrolase
IE4872_CH00877	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00882	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IE4872_CH00884	COG0477	Major facilitator Superfamily
IE4872_CH00891	COG0583	DNA-binding transcription factor activity
IE4872_CH00896	COG0306	phosphate transporter
IE4872_CH00898	COG0583	DNA-binding transcription factor activity
IE4872_CH00899	COG0277	FAD linked oxidase domain protein
IE4872_CH00900	COG0277	FAD linked oxidase domain protein
IE4872_CH00901	COG0247	lactate metabolic process
IE4872_CH00903	COG1376	ErfK ybiS ycfS ynhG family protein
IE4872_CH00903	COG1388	LysM domain
IE4872_CH00904	COG1376	ErfK ybiS ycfS ynhG family protein
IE4872_CH00905	COG2818	Glycosylase
IE4872_CH00908	COG0667	Aldo Keto reductase
IE4872_CH00914	COG0124	histidyl-tRNA synthetase
IE4872_CH00915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IE4872_CH00916	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IE4872_CH00917	COG2259	Doxx family
IE4872_CH00918	COG0625	glutathione transferase activity
IE4872_CH00921	COG0675	Transposase, IS605 OrfB family
IE4872_CH00924	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IE4872_CH00926	COG0196	riboflavin kinase activity
IE4872_CH00930	COG0590	tRNA wobble adenosine to inosine editing
IE4872_CH00931	COG1187	pseudouridine synthase activity
IE4872_CH00932	COG0742	ribosomal rna small subunit methyltransferase
IE4872_CH00934	COG0475	glutathione-regulated potassium exporter activity
IE4872_CH00934	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE4872_CH00935	COG0312	modulator of DNA gyrase
IE4872_CH00936	COG0483	inositol monophosphate 1-phosphatase activity
IE4872_CH00938	COG1519	Transferase
IE4872_CH00939	COG0546	phosphoglycolate phosphatase activity
IE4872_CH00940	COG1663	tetraacyldisaccharide 4'-kinase activity
IE4872_CH00942	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IE4872_CH00943	COG0745	RESPONSE REGULATOR receiver
IE4872_CH00944	COG5001	Diguanylate cyclase
IE4872_CH00947	COG3386	PFAM SMP-30 Gluconolaconase
IE4872_CH00948	COG0800	Aldolase
IE4872_CH00949	COG3734	2-keto-3-deoxy-galactonokinase
IE4872_CH00950	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH00951	COG1414	Transcriptional regulator
IE4872_CH00952	COG2197	response regulator
IE4872_CH00955	COG0489	protein tyrosine kinase activity
IE4872_CH00956	COG0598	Magnesium transport protein CorA
IE4872_CH00957	COG3158	transport of potassium into the cell
IE4872_CH00960	COG0356	it plays a direct role in the translocation of protons across the membrane
IE4872_CH00961	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IE4872_CH00962	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IE4872_CH00963	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IE4872_CH00966	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IE4872_CH00970	COG0521	Mo-molybdopterin cofactor biosynthetic process
IE4872_CH00971	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IE4872_CH00973	COG0142	geranyltranstransferase activity
IE4872_CH00976	COG1914	H( )-stimulated, divalent metal cation uptake system
IE4872_CH00979	COG0752	glycyl-tRNA synthetase alpha subunit
IE4872_CH00980	COG1704	LemA family
IE4872_CH00981	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IE4872_CH00983	COG0151	Belongs to the GarS family
IE4872_CH00985	COG1683	Conserved Protein
IE4872_CH00986	COG0751	glycine-tRNA ligase activity
IE4872_CH00987	COG2183	response to ionizing radiation
IE4872_CH00988	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IE4872_CH00991	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IE4872_CH00995	COG0009	L-threonylcarbamoyladenylate synthase
IE4872_CH01001	COG1960	acyl-CoA dehydrogenase activity
IE4872_CH01002	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IE4872_CH01004	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE4872_CH01006	COG0840	transmembrane signaling receptor activity
IE4872_CH01007	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IE4872_CH01008	COG1741	Belongs to the pirin family
IE4872_CH01010	COG1722	exodeoxyribonuclease VII activity
IE4872_CH01011	COG0123	including yeast histone deacetylase and acetoin utilization protein
IE4872_CH01013	COG1268	BioY protein
IE4872_CH01014	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IE4872_CH01015	COG1122	ATPase activity
IE4872_CH01016	COG3214	Protein conserved in bacteria
IE4872_CH01017	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE4872_CH01017	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE4872_CH01018	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IE4872_CH01022	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IE4872_CH01023	COG0484	heat shock protein binding
IE4872_CH01025	COG0259	pyridoxamine-phosphate oxidase activity
IE4872_CH01027	COG1686	Belongs to the peptidase S11 family
IE4872_CH01030	COG0312	modulator of DNA gyrase
IE4872_CH01032	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IE4872_CH01032	COG1565	acr, cog1565
IE4872_CH01033	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IE4872_CH01034	COG0109	protoheme IX farnesyltransferase activity
IE4872_CH01036	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IE4872_CH01040	COG3346	SURF1 family
IE4872_CH01041	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IE4872_CH01042	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IE4872_CH01043	COG0328	RNA-DNA hybrid ribonuclease activity
IE4872_CH01045	COG2186	Transcriptional regulator
IE4872_CH01051	COG2186	Transcriptional regulator
IE4872_CH01054	COG0803	Belongs to the bacterial solute-binding protein 9 family
IE4872_CH01055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE4872_CH01056	COG1121	(ABC) transporter
IE4872_CH01057	COG1733	regulation of RNA biosynthetic process
IE4872_CH01058	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01059	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IE4872_CH01059	COG0678	peroxiredoxin activity
IE4872_CH01061	COG1678	Uncharacterized ACR, COG1678
IE4872_CH01064	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE4872_CH01065	COG0612	Peptidase, M16
IE4872_CH01068	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE4872_CH01074	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IE4872_CH01079	COG1196	nuclear chromosome segregation
IE4872_CH01080	COG0574	Belongs to the PEP-utilizing enzyme family
IE4872_CH01080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IE4872_CH01086	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_CH01097	COG0667	Aldo Keto reductase
IE4872_CH01098	COG2207	Transcriptional regulator
IE4872_CH01100	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01104	COG0154	amidase activity
IE4872_CH01106	COG2207	Transcriptional regulator
IE4872_CH01107	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01112	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01113	COG4221	oxidoreductase activity
IE4872_CH01114	COG2895	sulfate adenylyltransferase (ATP) activity
IE4872_CH01115	COG0175	sulfate reduction
IE4872_CH01116	COG0175	sulfate reduction
IE4872_CH01118	COG1959	2 iron, 2 sulfur cluster binding
IE4872_CH01123	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IE4872_CH01124	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_CH01125	COG1309	transcriptional regulator
IE4872_CH01128	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IE4872_CH01137	COG0625	glutathione transferase activity
IE4872_CH01139	COG0583	DNA-binding transcription factor activity
IE4872_CH01141	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IE4872_CH01142	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IE4872_CH01144	COG0625	glutathione transferase activity
IE4872_CH01148	COG1793	dna ligase
IE4872_CH01151	COG1376	ErfK ybiS ycfS ynhG family protein
IE4872_CH01152	COG1376	ErfK ybiS ycfS ynhG family protein
IE4872_CH01153	COG0675	Transposase, IS605 OrfB family
IE4872_CH01155	COG3773	Cell wall hydrolase
IE4872_CH01155	COG3409	Peptidoglycan-binding domain 1 protein
IE4872_CH01158	COG1846	Transcriptional regulator
IE4872_CH01159	COG1764	response to oxidative stress
IE4872_CH01162	COG1846	Transcriptional regulator
IE4872_CH01166	COG0488	(ABC) transporter
IE4872_CH01167	COG2824	Alkylphosphonate utilization operon protein PhnA
IE4872_CH01168	COG0433	COG0433 Predicted ATPase
IE4872_CH01170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IE4872_CH01171	COG4106	trans-aconitate 2-methyltransferase activity
IE4872_CH01173	COG1335	isochorismatase
IE4872_CH01176	COG1064	alcohol dehydrogenase
IE4872_CH01177	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE4872_CH01180	COG0753	catalase activity
IE4872_CH01181	COG2814	Major facilitator Superfamily
IE4872_CH01182	COG0730	response to heat
IE4872_CH01188	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IE4872_CH01194	COG2010	Cytochrome c
IE4872_CH01203	COG4993	Dehydrogenase
IE4872_CH01205	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IE4872_CH01213	COG4106	trans-aconitate 2-methyltransferase activity
IE4872_CH01214	COG2514	catechol 2,3-dioxygenase activity
IE4872_CH01216	COG1272	protein, Hemolysin III
IE4872_CH01217	COG1247	-acetyltransferase
IE4872_CH01218	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE4872_CH01221	COG2111	Na H antiporter
IE4872_CH01222	COG1006	Multisubunit Na H antiporter MnhC subunit
IE4872_CH01224	COG1863	multisubunit Na H antiporter MnhE subunit
IE4872_CH01225	COG2212	antiporter activity
IE4872_CH01226	COG1320	monovalent cation:proton antiporter activity
IE4872_CH01227	COG4957	zinc ion binding
IE4872_CH01230	COG1959	2 iron, 2 sulfur cluster binding
IE4872_CH01234	COG2166	iron-sulfur cluster assembly
IE4872_CH01237	COG2205	protein histidine kinase activity
IE4872_CH01253	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IE4872_CH01254	COG2983	Belongs to the UPF0260 family
IE4872_CH01260	COG0745	RESPONSE REGULATOR receiver
IE4872_CH01261	COG2205	protein histidine kinase activity
IE4872_CH01263	COG4235	cytochrome complex assembly
IE4872_CH01264	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IE4872_CH01265	COG1138	Cytochrome C-type biogenesis protein
IE4872_CH01266	COG3088	subunit of a heme lyase
IE4872_CH01270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE4872_CH01271	COG0745	RESPONSE REGULATOR receiver
IE4872_CH01272	COG2205	protein histidine kinase activity
IE4872_CH01273	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IE4872_CH01274	COG2202	Pas domain
IE4872_CH01274	COG2205	protein histidine kinase activity
IE4872_CH01275	COG0308	aminopeptidase N
IE4872_CH01276	COG3290	protein histidine kinase activity
IE4872_CH01276	COG0840	transmembrane signaling receptor activity
IE4872_CH01282	COG0443	Heat shock 70 kDa protein
IE4872_CH01284	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_CH01286	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01289	COG1522	sequence-specific DNA binding
IE4872_CH01290	COG2239	Acts as a magnesium transporter
IE4872_CH01293	COG1733	regulation of RNA biosynthetic process
IE4872_CH01294	COG2814	Major facilitator Superfamily
IE4872_CH01297	COG0174	glutamine synthetase
IE4872_CH01299	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IE4872_CH01300	COG0463	Glycosyl transferase, family 2
IE4872_CH01302	COG4941	Belongs to the sigma-70 factor family
IE4872_CH01304	COG3795	YCII-related domain
IE4872_CH01305	COG3795	YCII-related domain
IE4872_CH01307	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IE4872_CH01309	COG0625	glutathione transferase activity
IE4872_CH01312	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IE4872_CH01321	COG3718	enzyme involved in inositol metabolism
IE4872_CH01322	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_CH01323	COG3962	Belongs to the TPP enzyme family
IE4872_CH01324	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_CH01326	COG0673	inositol 2-dehydrogenase activity
IE4872_CH01330	COG0596	Alpha beta hydrolase
IE4872_CH01330	COG2945	thiolester hydrolase activity
IE4872_CH01331	COG0741	lytic transglycosylase activity
IE4872_CH01332	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_CH01333	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IE4872_CH01336	COG1758	RNA polymerase activity
IE4872_CH01339	COG0736	holo-[acyl-carrier-protein] synthase activity
IE4872_CH01340	COG0681	Belongs to the peptidase S26 family
IE4872_CH01341	COG0571	ribonuclease III activity
IE4872_CH01342	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IE4872_CH01344	COG1381	Involved in DNA repair and RecF pathway recombination
IE4872_CH01347	COG1418	mRNA catabolic process
IE4872_CH01348	COG3300	MHYT domain
IE4872_CH01348	COG5001	Diguanylate cyclase
IE4872_CH01350	COG2032	superoxide dismutase activity
IE4872_CH01352	COG0668	transmembrane transport
IE4872_CH01354	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IE4872_CH01359	COG1051	belongs to the nudix hydrolase family
IE4872_CH01360	COG1742	UPF0060 membrane protein
IE4872_CH01363	COG1183	phosphatidylcholine synthase activity
IE4872_CH01364	COG0688	phosphatidylethanolamine metabolic process
IE4872_CH01365	COG5265	(ABC) transporter
IE4872_CH01366	COG1388	LysM domain
IE4872_CH01369	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IE4872_CH01370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IE4872_CH01375	COG0215	cysteine-tRNA ligase activity
IE4872_CH01378	COG4221	oxidoreductase activity
IE4872_CH01379	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IE4872_CH01380	COG1286	toxin biosynthetic process
IE4872_CH01382	COG1280	lysine exporter protein (LysE YggA)
IE4872_CH01383	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE4872_CH01384	COG0305	Participates in initiation and elongation during chromosome replication
IE4872_CH01386	COG0359	binds to the 23S rRNA
IE4872_CH01388	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IE4872_CH01389	COG0360	Binds together with S18 to 16S ribosomal RNA
IE4872_CH01391	COG0667	Aldo Keto reductase
IE4872_CH01392	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IE4872_CH01394	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE4872_CH01395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE4872_CH01396	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IE4872_CH01397	COG1561	YicC-like family, N-terminal region
IE4872_CH01398	COG0194	GDP metabolic process
IE4872_CH01399	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IE4872_CH01400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IE4872_CH01402	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IE4872_CH01405	COG0671	phosphoesterase, PA-phosphatase related
IE4872_CH01406	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IE4872_CH01411	COG0105	UTP biosynthetic process
IE4872_CH01415	COG0314	molybdopterin synthase activity
IE4872_CH01417	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IE4872_CH01418	COG0322	excinuclease ABC activity
IE4872_CH01419	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01422	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IE4872_CH01423	COG0243	molybdopterin cofactor binding
IE4872_CH01426	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IE4872_CH01427	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IE4872_CH01428	COG0628	permease
IE4872_CH01433	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_CH01434	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IE4872_CH01436	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IE4872_CH01438	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IE4872_CH01441	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IE4872_CH01443	COG0113	porphobilinogen synthase activity
IE4872_CH01447	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IE4872_CH01448	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IE4872_CH01449	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IE4872_CH01449	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IE4872_CH01455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IE4872_CH01456	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IE4872_CH01457	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IE4872_CH01461	COG0416	fatty acid biosynthetic process
IE4872_CH01462	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IE4872_CH01463	COG0776	regulation of translation
IE4872_CH01466	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE4872_CH01475	COG0297	glycogen (starch) synthase activity
IE4872_CH01480	COG1612	heme a metabolic process
IE4872_CH01482	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IE4872_CH01483	COG0010	Belongs to the arginase family
IE4872_CH01485	COG1522	sequence-specific DNA binding
IE4872_CH01486	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IE4872_CH01487	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IE4872_CH01493	COG1832	CoA-binding protein
IE4872_CH01497	COG4221	oxidoreductase activity
IE4872_CH01498	COG2124	cytochrome p450
IE4872_CH01499	COG3706	GGDEF domain
IE4872_CH01500	COG0740	serine-type endopeptidase activity
IE4872_CH01501	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IE4872_CH01502	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IE4872_CH01503	COG0776	regulation of translation
IE4872_CH01504	COG0697	spore germination
IE4872_CH01506	COG0667	Aldo Keto reductase
IE4872_CH01510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_CH01511	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_CH01512	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_CH01513	COG0649	NAD binding
IE4872_CH01515	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IE4872_CH01516	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IE4872_CH01517	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IE4872_CH01517	COG3743	rRNA binding
IE4872_CH01519	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IE4872_CH01520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_CH01522	COG0713	ATP synthesis coupled electron transport
IE4872_CH01525	COG1007	ATP synthesis coupled electron transport
IE4872_CH01530	COG0442	prolyl-tRNA aminoacylation
IE4872_CH01532	COG1136	(ABC) transporter
IE4872_CH01535	COG0587	DNA-directed DNA polymerase activity
IE4872_CH01539	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE4872_CH01544	COG0784	Response regulator, receiver
IE4872_CH01545	COG0745	RESPONSE REGULATOR receiver
IE4872_CH01545	COG3706	GGDEF domain
IE4872_CH01546	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IE4872_CH01547	COG0477	Major facilitator Superfamily
IE4872_CH01549	COG0557	exoribonuclease II activity
IE4872_CH01550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IE4872_CH01553	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IE4872_CH01555	COG0540	Belongs to the ATCase OTCase family
IE4872_CH01556	COG1960	acyl-CoA dehydrogenase activity
IE4872_CH01560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IE4872_CH01561	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IE4872_CH01562	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IE4872_CH01563	COG0154	amidase activity
IE4872_CH01565	COG3811	Belongs to the UPF0386 family
IE4872_CH01568	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IE4872_CH01572	COG4765	Protein conserved in bacteria
IE4872_CH01573	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IE4872_CH01575	COG0511	ligase activity, forming carbon-carbon bonds
IE4872_CH01576	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IE4872_CH01578	COG0436	Aminotransferase
IE4872_CH01579	COG1530	ribonuclease E activity
IE4872_CH01581	COG0860	N-Acetylmuramoyl-L-alanine amidase
IE4872_CH01582	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IE4872_CH01586	COG1132	(ABC) transporter
IE4872_CH01590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IE4872_CH01631	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE4872_CH01636	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IE4872_CH01641	COG0250	Participates in transcription elongation, termination and antitermination
IE4872_CH01642	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IE4872_CH01643	COG0081	regulation of translation
IE4872_CH01645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IE4872_CH01646	COG0222	ribosome binding
IE4872_CH01647	COG0085	RNA polymerase activity
IE4872_CH01648	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IE4872_CH01652	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IE4872_CH01653	COG0049	tRNA binding
IE4872_CH01654	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IE4872_CH01655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IE4872_CH01656	COG0051	transcription antitermination factor activity, RNA binding
IE4872_CH01657	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IE4872_CH01658	COG0088	Forms part of the polypeptide exit tunnel
IE4872_CH01659	COG0089	rRNA binding
IE4872_CH01660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IE4872_CH01661	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IE4872_CH01662	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IE4872_CH01663	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IE4872_CH01664	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IE4872_CH01665	COG0255	Belongs to the universal ribosomal protein uL29 family
IE4872_CH01666	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IE4872_CH01667	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IE4872_CH01668	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IE4872_CH01669	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IE4872_CH01670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IE4872_CH01671	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IE4872_CH01672	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IE4872_CH01673	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IE4872_CH01674	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IE4872_CH01675	COG1841	ribosomal large subunit assembly
IE4872_CH01676	COG0200	Binds to the 23S rRNA
IE4872_CH01678	COG0563	adenylate kinase activity
IE4872_CH01679	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IE4872_CH01680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IE4872_CH01681	COG0202	RNA polymerase activity
IE4872_CH01682	COG0203	ribosomal protein L17
IE4872_CH01683	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IE4872_CH01684	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IE4872_CH01685	COG0129	dihydroxy-acid dehydratase activity
IE4872_CH01688	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE4872_CH01689	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IE4872_CH01692	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IE4872_CH01694	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IE4872_CH01695	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01696	COG0583	DNA-binding transcription factor activity
IE4872_CH01698	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IE4872_CH01699	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IE4872_CH01706	COG2072	flavoprotein involved in K transport
IE4872_CH01710	COG1129	ABC transporter
IE4872_CH01711	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH01712	COG1879	ABC-type sugar transport system periplasmic component
IE4872_CH01713	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_CH01714	COG0673	inositol 2-dehydrogenase activity
IE4872_CH01715	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_CH01718	COG3962	Belongs to the TPP enzyme family
IE4872_CH01719	COG3718	enzyme involved in inositol metabolism
IE4872_CH01720	COG1942	4-Oxalocrotonate Tautomerase
IE4872_CH01721	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IE4872_CH01723	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IE4872_CH01725	COG1058	Belongs to the CinA family
IE4872_CH01725	COG1546	Belongs to the CinA family
IE4872_CH01726	COG0655	NAD(P)H dehydrogenase (quinone) activity
IE4872_CH01730	COG0387	Pfam Sodium calcium exchanger
IE4872_CH01731	COG0786	glutamate:sodium symporter activity
IE4872_CH01734	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE4872_CH01736	COG3706	GGDEF domain
IE4872_CH01737	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IE4872_CH01738	COG0583	DNA-binding transcription factor activity
IE4872_CH01739	COG0737	Belongs to the 5'-nucleotidase family
IE4872_CH01742	COG1522	sequence-specific DNA binding
IE4872_CH01743	COG0686	Belongs to the AlaDH PNT family
IE4872_CH01746	COG2897	thiosulfate sulfurtransferase activity
IE4872_CH01747	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IE4872_CH01749	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH01783	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IE4872_CH01785	COG0525	valine-tRNA ligase activity
IE4872_CH01791	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IE4872_CH01792	COG0018	arginyl-trna synthetase
IE4872_CH01795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IE4872_CH01797	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IE4872_CH01798	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IE4872_CH01799	COG0805	protein transport
IE4872_CH01800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IE4872_CH01801	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IE4872_CH01802	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IE4872_CH01803	COG0739	heme binding
IE4872_CH01810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IE4872_CH01817	COG2197	response regulator
IE4872_CH01820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IE4872_CH01821	COG1215	transferase activity, transferring glycosyl groups
IE4872_CH01830	COG0544	peptidyl-prolyl cis-trans isomerase activity
IE4872_CH01835	COG0667	Aldo Keto reductase
IE4872_CH01836	COG0583	DNA-binding transcription factor activity
IE4872_CH01837	COG3920	Histidine kinase
IE4872_CH01838	COG0024	Methionine aminopeptidase
IE4872_CH01845	COG3243	poly(R)-hydroxyalkanoic acid synthase
IE4872_CH01847	COG0436	Aminotransferase
IE4872_CH01849	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IE4872_CH01850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IE4872_CH01851	COG1091	dTDP-4-dehydrorhamnose reductase activity
IE4872_CH01852	COG1088	dTDP-glucose 4,6-dehydratase activity
IE4872_CH01853	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IE4872_CH01867	COG1309	transcriptional regulator
IE4872_CH01880	COG1278	Cold shock
IE4872_CH01891	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IE4872_CH01898	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IE4872_CH01911	COG0110	maltose O-acetyltransferase activity
IE4872_CH01917	COG1126	abc transporter atp-binding protein
IE4872_CH01918	COG0765	amino acid transport
IE4872_CH01919	COG4597	amino acid ABC transporter
IE4872_CH01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_CH01921	COG0626	cystathionine gamma-synthase activity
IE4872_CH01924	COG2267	carboxylic ester hydrolase activity
IE4872_CH01929	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IE4872_CH01931	COG0537	adenosine 5'-monophosphoramidase activity
IE4872_CH01937	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IE4872_CH01938	COG0052	Belongs to the universal ribosomal protein uS2 family
IE4872_CH01939	COG0052	Belongs to the universal ribosomal protein uS2 family
IE4872_CH01940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IE4872_CH01941	COG0528	UMP kinase activity
IE4872_CH01942	COG0233	cytoplasmic translational termination
IE4872_CH01943	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IE4872_CH01945	COG0750	zinc metalloprotease
IE4872_CH01946	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE4872_CH01947	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE4872_CH01948	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IE4872_CH01949	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE4872_CH01950	COG3494	Protein of unknown function (DUF1009)
IE4872_CH01951	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE4872_CH01952	COG0372	Belongs to the citrate synthase family
IE4872_CH01955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE4872_CH01957	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IE4872_CH01958	COG0840	transmembrane signaling receptor activity
IE4872_CH01959	COG0148	phosphopyruvate hydratase activity
IE4872_CH01961	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IE4872_CH01962	COG0022	dehydrogenase e1 component
IE4872_CH01962	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE4872_CH01963	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE4872_CH01966	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE4872_CH01969	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IE4872_CH01971	COG2867	negative regulation of translational initiation
IE4872_CH01972	COG1546	Belongs to the CinA family
IE4872_CH01973	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IE4872_CH01973	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IE4872_CH01975	COG3852	Histidine kinase
IE4872_CH01976	COG2204	response regulator
IE4872_CH01977	COG5000	phosphorelay sensor kinase activity
IE4872_CH01978	COG2204	response regulator
IE4872_CH01979	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE4872_CH01980	COG1923	regulation of RNA biosynthetic process
IE4872_CH01981	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IE4872_CH01982	COG3956	TIGRFAM MazG family protein
IE4872_CH01984	COG1648	precorrin-2 dehydrogenase activity
IE4872_CH01984	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IE4872_CH01986	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IE4872_CH01988	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE4872_CH01989	COG0785	Cytochrome C biogenesis protein
IE4872_CH01993	COG1917	Cupin 2, conserved barrel domain protein
IE4872_CH01993	COG4977	sequence-specific DNA binding
IE4872_CH01999	COG1566	PFAM secretion protein HlyD family protein
IE4872_CH02000	COG1136	(ABC) transporter
IE4872_CH02000	COG0577	efflux transmembrane transporter activity
IE4872_CH02001	COG1136	(ABC) transporter
IE4872_CH02001	COG0577	efflux transmembrane transporter activity
IE4872_CH02002	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_CH02005	COG1183	phosphatidylcholine synthase activity
IE4872_CH02007	COG1129	ABC transporter
IE4872_CH02011	COG1879	ABC-type sugar transport system periplasmic component
IE4872_CH02012	COG1129	ABC transporter
IE4872_CH02013	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH02014	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH02015	COG2186	Transcriptional regulator
IE4872_CH02016	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IE4872_CH02017	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE4872_CH02019	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IE4872_CH02021	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IE4872_CH02023	COG4166	transmembrane transport
IE4872_CH02026	COG0174	glutamine synthetase
IE4872_CH02027	COG0347	Belongs to the P(II) protein family
IE4872_CH02028	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IE4872_CH02028	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IE4872_CH02030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IE4872_CH02031	COG0629	single-stranded DNA binding
IE4872_CH02034	COG2095	MarC family integral membrane protein
IE4872_CH02035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IE4872_CH02040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IE4872_CH02041	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IE4872_CH02042	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IE4872_CH02043	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IE4872_CH02044	COG0343	queuine tRNA-ribosyltransferase activity
IE4872_CH02054	COG0640	Transcriptional regulator
IE4872_CH02055	COG2826	transposase and inactivated derivatives, IS30 family
IE4872_CH02057	COG2226	methyltransferase
IE4872_CH02058	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IE4872_CH02058	COG0321	lipoyl(octanoyl) transferase activity
IE4872_CH02059	COG0084	hydrolase, TatD family'
IE4872_CH02060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE4872_CH02061	COG0730	response to heat
IE4872_CH02063	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IE4872_CH02076	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IE4872_CH02077	COG0134	indole-3-glycerol-phosphate synthase activity
IE4872_CH02078	COG0315	cyclic pyranopterin monophosphate synthase activity
IE4872_CH02082	COG0513	Belongs to the DEAD box helicase family
IE4872_CH02085	COG0372	Belongs to the citrate synthase family
IE4872_CH02086	COG0372	Belongs to the citrate synthase family
IE4872_CH02088	COG0504	CTP synthase activity
IE4872_CH02090	COG0149	triose-phosphate isomerase activity
IE4872_CH02092	COG0187	DNA topoisomerase II activity
IE4872_CH02095	COG0628	permease
IE4872_CH02103	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IE4872_CH02105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IE4872_CH02107	COG0302	gtp cyclohydrolase
IE4872_CH02108	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IE4872_CH02109	COG1752	Esterase of the alpha-beta hydrolase superfamily
IE4872_CH02110	COG2239	Acts as a magnesium transporter
IE4872_CH02114	COG2267	carboxylic ester hydrolase activity
IE4872_CH02117	COG1686	Belongs to the peptidase S11 family
IE4872_CH02120	COG1760	l-serine dehydratase
IE4872_CH02125	COG2239	Acts as a magnesium transporter
IE4872_CH02127	COG0242	peptide deformylase activity
IE4872_CH02130	COG0321	lipoyl(octanoyl) transferase activity
IE4872_CH02135	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IE4872_CH02136	COG1671	Belongs to the UPF0178 family
IE4872_CH02137	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IE4872_CH02139	COG2259	Doxx family
IE4872_CH02140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IE4872_CH02143	COG0546	phosphoglycolate phosphatase activity
IE4872_CH02145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IE4872_CH02150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IE4872_CH02151	COG0509	glycine decarboxylation via glycine cleavage system
IE4872_CH02152	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IE4872_CH02152	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IE4872_CH02154	COG1749	Flagellar hook protein flgE
IE4872_CH02156	COG0316	Belongs to the HesB IscA family
IE4872_CH02157	COG2151	metal-sulfur cluster biosynthetic enzyme
IE4872_CH02158	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IE4872_CH02159	COG0719	Fe-S assembly protein
IE4872_CH02160	COG0396	ATPase activity
IE4872_CH02161	COG0719	Fe-S assembly protein
IE4872_CH02163	COG2945	thiolester hydrolase activity
IE4872_CH02165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IE4872_CH02166	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IE4872_CH02168	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IE4872_CH02169	COG2833	Protein of unknown function (DUF455)
IE4872_CH02170	COG1196	nuclear chromosome segregation
IE4872_CH02170	COG0741	lytic transglycosylase activity
IE4872_CH02170	COG0739	heme binding
IE4872_CH02171	COG0513	Belongs to the DEAD box helicase family
IE4872_CH02175	COG3608	succinylglutamate desuccinylase aspartoacylase
IE4872_CH02175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IE4872_CH02178	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IE4872_CH02179	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE4872_CH02183	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IE4872_CH02188	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IE4872_CH02189	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IE4872_CH02190	COG0047	phosphoribosylformylglycinamidine synthase activity
IE4872_CH02193	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_CH02195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IE4872_CH02199	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IE4872_CH02200	COG2814	Major facilitator Superfamily
IE4872_CH02201	COG2814	Major facilitator Superfamily
IE4872_CH02204	COG0483	inositol monophosphate 1-phosphatase activity
IE4872_CH02205	COG0037	tRNA processing
IE4872_CH02206	COG2066	Belongs to the glutaminase family
IE4872_CH02207	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IE4872_CH02210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IE4872_CH02211	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IE4872_CH02213	COG0538	isocitrate dehydrogenase activity
IE4872_CH02217	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IE4872_CH02218	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IE4872_CH02219	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_CH02220	COG2313	pseudouridylate synthase activity
IE4872_CH02223	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IE4872_CH02225	COG3106	COG3106 Predicted ATPase
IE4872_CH02226	COG3768	UPF0283 membrane protein
IE4872_CH02230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IE4872_CH02232	COG0633	Ferredoxin
IE4872_CH02238	COG1127	ABC transporter
IE4872_CH02239	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IE4872_CH02240	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_CH02241	COG2814	Major facilitator Superfamily
IE4872_CH02242	COG0456	acetyltransferase
IE4872_CH02244	COG0280	phosphate acetyltransferase
IE4872_CH02244	COG0281	malic enzyme
IE4872_CH02246	COG0778	Nitroreductase
IE4872_CH02247	COG0823	Involved in the tonB-independent uptake of proteins
IE4872_CH02249	COG1368	sulfuric ester hydrolase activity
IE4872_CH02253	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IE4872_CH02257	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IE4872_CH02258	COG0546	phosphoglycolate phosphatase activity
IE4872_CH02259	COG2989	Protein conserved in bacteria
IE4872_CH02260	COG0114	fumarate hydratase activity
IE4872_CH02262	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE4872_CH02262	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE4872_CH02264	COG3706	GGDEF domain
IE4872_CH02267	COG1846	Transcriptional regulator
IE4872_CH02270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IE4872_CH02272	COG3237	CsbD-like
IE4872_CH02276	COG0746	molybdenum cofactor guanylyltransferase activity
IE4872_CH02277	COG1763	Mo-molybdopterin cofactor biosynthetic process
IE4872_CH02279	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_CH02282	COG5425	PFAM Usg family protein
IE4872_CH02287	COG1116	anion transmembrane transporter activity
IE4872_CH02288	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_CH02289	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_CH02290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE4872_CH02291	COG2084	Dehydrogenase
IE4872_CH02293	COG1522	sequence-specific DNA binding
IE4872_CH02294	COG1573	uracil-dna glycosylase
IE4872_CH02296	COG2202	Pas domain
IE4872_CH02296	COG2205	protein histidine kinase activity
IE4872_CH02299	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IE4872_CH02300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IE4872_CH02310	COG0842	Transport permease protein
IE4872_CH02311	COG1131	(ABC) transporter
IE4872_CH02312	COG0730	response to heat
IE4872_CH02316	COG0840	transmembrane signaling receptor activity
IE4872_CH02317	COG1607	acyl-coa hydrolase
IE4872_CH02323	COG4178	(ABC) transporter
IE4872_CH02327	COG3795	YCII-related domain
IE4872_CH02330	COG0556	nucleotide-excision repair
IE4872_CH02331	COG0484	heat shock protein binding
IE4872_CH02333	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IE4872_CH02341	COG0735	belongs to the Fur family
IE4872_CH02342	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE4872_CH02343	COG1121	(ABC) transporter
IE4872_CH02344	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IE4872_CH02349	COG0456	acetyltransferase
IE4872_CH02350	COG3507	Belongs to the glycosyl hydrolase 43 family
IE4872_CH02351	COG0667	Aldo Keto reductase
IE4872_CH02352	COG0673	inositol 2-dehydrogenase activity
IE4872_CH02356	COG0395	ABC-type sugar transport system, permease component
IE4872_CH02358	COG1653	transport
IE4872_CH02361	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IE4872_CH02367	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE4872_CH02369	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IE4872_CH02370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE4872_CH02384	COG1492	cobalamin metabolic process
IE4872_CH02389	COG0583	DNA-binding transcription factor activity
IE4872_CH02394	COG0745	RESPONSE REGULATOR receiver
IE4872_CH02395	COG0745	RESPONSE REGULATOR receiver
IE4872_CH02396	COG0704	Plays a role in the regulation of phosphate uptake
IE4872_CH02397	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IE4872_CH02399	COG0573	inorganic phosphate transmembrane transporter activity
IE4872_CH02400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IE4872_CH02401	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IE4872_CH02404	COG3639	organic phosphonate transmembrane transporter activity
IE4872_CH02411	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE4872_CH02412	COG0673	inositol 2-dehydrogenase activity
IE4872_CH02415	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_CH02416	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_CH02429	COG4191	Histidine kinase
IE4872_CH02432	COG2267	carboxylic ester hydrolase activity
IE4872_CH02433	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_CH02436	COG4566	intracellular signal transduction
IE4872_CH02442	COG1335	isochorismatase
IE4872_CH02445	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH02449	COG4191	Histidine kinase
IE4872_CH02450	COG0745	RESPONSE REGULATOR receiver
IE4872_CH02451	COG0596	Alpha beta hydrolase
IE4872_CH02456	COG0697	spore germination
IE4872_CH02457	COG1525	nuclease
IE4872_CH02461	COG1309	transcriptional regulator
IE4872_CH02465	COG3034	peptidoglycan biosynthetic process
IE4872_CH02467	COG2132	Multicopper oxidase
IE4872_CH02469	COG1278	Cold shock
IE4872_CH02471	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE4872_CH02480	COG0789	Transcriptional regulator
IE4872_CH02488	COG1238	metal cluster binding
IE4872_CH02500	COG0745	RESPONSE REGULATOR receiver
IE4872_CH02500	COG3706	GGDEF domain
IE4872_CH02503	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IE4872_CH02503	COG3264	Mechanosensitive ion channel
IE4872_CH02505	COG3920	Histidine kinase
IE4872_CH02508	COG0697	spore germination
IE4872_CH02516	COG0384	phenazine biosynthesis protein PhzF
IE4872_CH02519	COG3842	ATPase activity
IE4872_CH02520	COG4149	molybdate abc transporter
IE4872_CH02522	COG0667	Aldo Keto reductase
IE4872_CH02523	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_CH02526	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IE4872_CH02528	COG2207	Transcriptional regulator
IE4872_CH02530	COG1064	alcohol dehydrogenase
IE4872_CH02531	COG1252	NADH dehydrogenase
IE4872_CH02532	COG1522	sequence-specific DNA binding
IE4872_CH02533	COG1794	racemase activity, acting on amino acids and derivatives
IE4872_CH02534	COG1846	Transcriptional regulator
IE4872_CH02534	COG0456	acetyltransferase
IE4872_CH02535	COG1309	transcriptional regulator
IE4872_CH02536	COG2814	Major facilitator Superfamily
IE4872_CH02537	COG1733	regulation of RNA biosynthetic process
IE4872_CH02539	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IE4872_CH02542	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE4872_CH02544	COG0488	(ABC) transporter
IE4872_CH02555	COG0656	L-ascorbic acid biosynthetic process
IE4872_CH02557	COG0028	Belongs to the TPP enzyme family
IE4872_CH02560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IE4872_CH02561	COG0560	Phosphoserine phosphatase
IE4872_CH02561	COG3830	Belongs to the UPF0237 family
IE4872_CH02563	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE4872_CH02565	COG0330	HflC and HflK could
IE4872_CH02570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IE4872_CH02575	COG0277	FAD linked oxidase domain protein
IE4872_CH02576	COG0667	Aldo Keto reductase
IE4872_CH02577	COG0583	DNA-binding transcription factor activity
IE4872_CH02578	COG3180	Ammonia monooxygenase
IE4872_CH02581	COG2885	chlorophyll binding
IE4872_CH02582	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IE4872_CH02583	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE4872_CH02588	COG1335	isochorismatase
IE4872_CH02592	COG0006	proline dipeptidase activity
IE4872_CH02594	COG2264	protein methyltransferase activity
IE4872_CH02596	COG1999	signal sequence binding
IE4872_CH02597	COG0835	chemotaxis
IE4872_CH02602	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IE4872_CH02604	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE4872_CH02606	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IE4872_CH02607	COG0849	cell division
IE4872_CH02608	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IE4872_CH02609	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE4872_CH02610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IE4872_CH02611	COG0477	Major facilitator Superfamily
IE4872_CH02612	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IE4872_CH02613	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IE4872_CH02614	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IE4872_CH02616	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IE4872_CH02617	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IE4872_CH02619	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IE4872_CH02622	COG0275	rRNA processing
IE4872_CH02623	COG2001	Belongs to the MraZ family
IE4872_CH02627	COG3023	N-Acetylmuramoyl-L-alanine amidase
IE4872_CH02630	COG1280	lysine exporter protein (LysE YggA)
IE4872_CH02638	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IE4872_CH02639	COG2226	methyltransferase
IE4872_CH02644	COG0697	spore germination
IE4872_CH02645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IE4872_CH02646	COG0028	Belongs to the TPP enzyme family
IE4872_CH02647	COG0251	oxidation-reduction process
IE4872_CH02650	COG1376	ErfK ybiS ycfS ynhG family protein
IE4872_CH02651	COG1192	Involved in chromosome partitioning
IE4872_CH02654	COG0174	glutamine synthetase
IE4872_CH02661	COG3842	ATPase activity
IE4872_CH02663	COG0673	inositol 2-dehydrogenase activity
IE4872_CH02664	COG0395	ABC-type sugar transport system, permease component
IE4872_CH02667	COG2971	BadF BadG BcrA BcrD
IE4872_CH02672	COG4702	Belongs to the UPF0303 family
IE4872_CH02675	COG2968	Membrane
IE4872_CH02686	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH02689	COG1024	Enoyl-CoA hydratase
IE4872_CH02691	COG0673	inositol 2-dehydrogenase activity
IE4872_CH02692	COG1609	Transcriptional regulator
IE4872_CH02694	COG0432	Pfam Uncharacterised protein family UPF0047
IE4872_CH02695	COG5507	3-demethylubiquinone-9 3-methyltransferase
IE4872_CH02698	COG3448	diguanylate cyclase activity
IE4872_CH02698	COG4175	Glycine betaine
IE4872_CH02700	COG0697	spore germination
IE4872_CH02705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IE4872_CH02708	COG1063	alcohol dehydrogenase
IE4872_CH02709	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_CH02711	COG0514	ATP-dependent DNA helicase (RecQ)
IE4872_CH02712	COG0358	DNA primase activity
IE4872_CH02716	COG0505	Belongs to the CarA family
IE4872_CH02718	COG0534	Mate efflux family protein
IE4872_CH02720	COG0667	Aldo Keto reductase
IE4872_CH02721	COG2321	neutral zinc metallopeptidase
IE4872_CH02722	COG1063	alcohol dehydrogenase
IE4872_CH02723	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IE4872_CH02725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE4872_CH02727	COG0438	transferase activity, transferring glycosyl groups
IE4872_CH02728	COG1522	sequence-specific DNA binding
IE4872_CH02729	COG0492	ferredoxin-NADP+ reductase activity
IE4872_CH02730	COG0583	DNA-binding transcription factor activity
IE4872_CH02734	COG1902	pentaerythritol trinitrate reductase activity
IE4872_CH02742	COG2133	pyrroloquinoline quinone binding
IE4872_CH02745	COG1278	Cold shock
IE4872_CH02747	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_CH02750	COG1846	Transcriptional regulator
IE4872_CH02751	COG0745	RESPONSE REGULATOR receiver
IE4872_CH02752	COG2205	protein histidine kinase activity
IE4872_CH02755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE4872_CH02759	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IE4872_CH02764	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IE4872_CH02768	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IE4872_CH02769	COG5001	Diguanylate cyclase
IE4872_CH02769	COG3300	MHYT domain
IE4872_CH02771	COG0193	aminoacyl-tRNA hydrolase activity
IE4872_CH02774	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IE4872_CH02775	COG0012	GTP binding
IE4872_CH02778	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IE4872_CH02779	COG2857	Cytochrome c1
IE4872_CH02779	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IE4872_CH02781	COG0723	plastoquinol--plastocyanin reductase activity
IE4872_CH02782	COG1132	(ABC) transporter
IE4872_CH02784	COG1132	(ABC) transporter
IE4872_CH02785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IE4872_CH02788	COG0408	coproporphyrinogen oxidase activity
IE4872_CH02791	COG0617	tRNA 3'-terminal CCA addition
IE4872_CH02794	COG0714	Associated with various cellular activities
IE4872_CH02798	COG0477	Major facilitator Superfamily
IE4872_CH02801	COG0435	Glutathione S-transferase
IE4872_CH02808	COG1733	regulation of RNA biosynthetic process
IE4872_CH02809	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IE4872_CH02811	COG3135	benzoate transporter
IE4872_CH02812	COG0740	serine-type endopeptidase activity
IE4872_CH02814	COG3416	Protein conserved in bacteria
IE4872_CH02815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IE4872_CH02816	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IE4872_CH02819	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IE4872_CH02819	COG0512	Glutamine amidotransferase of anthranilate synthase
IE4872_CH02823	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IE4872_CH02824	COG2197	response regulator
IE4872_CH02828	COG1435	thymidine kinase activity
IE4872_CH02831	COG3448	diguanylate cyclase activity
IE4872_CH02831	COG4175	Glycine betaine
IE4872_CH02837	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IE4872_CH02838	COG0366	Alpha amylase catalytic
IE4872_CH02840	COG0601	transmembrane transport
IE4872_CH02841	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_CH02843	COG4608	Belongs to the ABC transporter superfamily
IE4872_CH02846	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_CH02849	COG1846	Transcriptional regulator
IE4872_CH02851	COG1160	GTP binding
IE4872_CH02855	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IE4872_CH02858	COG0024	Methionine aminopeptidase
IE4872_CH02861	COG4941	Belongs to the sigma-70 factor family
IE4872_CH02862	COG3795	YCII-related domain
IE4872_CH02863	COG1309	transcriptional regulator
IE4872_CH02866	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IE4872_CH02867	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH02869	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_CH02872	COG0583	DNA-binding transcription factor activity
IE4872_CH02875	COG0402	S-adenosylhomocysteine deaminase activity
IE4872_CH02879	COG1304	FMN binding
IE4872_CH02880	COG2072	flavoprotein involved in K transport
IE4872_CH02886	COG2351	hydroxyisourate hydrolase activity
IE4872_CH02887	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IE4872_CH02890	COG4266	Belongs to the allantoicase family
IE4872_CH02891	COG3648	Uricase
IE4872_CH02891	COG3195	allantoin biosynthetic process
IE4872_CH02898	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IE4872_CH02898	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH02899	COG0784	Response regulator, receiver
IE4872_CH02899	COG5002	protein histidine kinase activity
IE4872_CH02899	COG2205	protein histidine kinase activity
IE4872_CH02901	COG0513	Belongs to the DEAD box helicase family
IE4872_CH02902	COG1032	radical SAM domain protein
IE4872_CH02904	COG0673	inositol 2-dehydrogenase activity
IE4872_CH02911	COG4214	carbohydrate transport
IE4872_CH02913	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_CH02916	COG3436	PFAM IS66 Orf2 family protein
IE4872_CH02920	COG2201	protein-glutamate methylesterase activity
IE4872_CH02928	COG2308	Evidence 4 Homologs of previously reported genes of
IE4872_CH02930	COG4213	ABC transporter substrate-binding protein
IE4872_CH02931	COG4214	carbohydrate transport
IE4872_CH02932	COG1129	ABC transporter
IE4872_CH02934	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IE4872_CH02945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE4872_CH02961	COG3546	catalase activity
IE4872_CH02965	COG0297	glycogen (starch) synthase activity
IE4872_CH02967	COG0562	UDP-galactopyranose mutase
IE4872_CH02976	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH02984	COG0628	permease
IE4872_CH02987	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH02988	COG1309	transcriptional regulator
IE4872_CH02989	COG3264	Mechanosensitive ion channel
IE4872_CH02989	COG1511	domain protein
IE4872_CH02992	COG0431	NADPH-dependent FMN reductase
IE4872_CH02994	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IE4872_CH02995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE4872_CH02996	COG0640	Transcriptional regulator
IE4872_CH02999	COG2197	response regulator
IE4872_CH03011	COG0489	protein tyrosine kinase activity
IE4872_CH03011	COG3206	protein involved in exopolysaccharide biosynthesis
IE4872_CH03012	COG1596	polysaccharide export
IE4872_CH03013	COG0438	transferase activity, transferring glycosyl groups
IE4872_CH03014	COG0673	inositol 2-dehydrogenase activity
IE4872_CH03016	COG2076	Multidrug Resistance protein
IE4872_CH03018	COG2346	COG2346, Truncated hemoglobins
IE4872_CH03028	COG4558	Periplasmic binding protein
IE4872_CH03029	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE4872_CH03030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IE4872_CH03036	COG0784	Response regulator, receiver
IE4872_CH03038	COG0493	'glutamate synthase
IE4872_CH03040	COG2207	Transcriptional regulator
IE4872_CH03042	COG0598	Magnesium transport protein CorA
IE4872_CH03044	COG0583	DNA-binding transcription factor activity
IE4872_CH03045	COG4251	negative regulation of phosphorylation
IE4872_CH03046	COG1309	transcriptional regulator
IE4872_CH03052	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_CH03053	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_CH03054	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE4872_CH03058	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IE4872_CH03059	COG0830	nickel cation binding
IE4872_CH03060	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IE4872_CH03061	COG3706	GGDEF domain
IE4872_CH03062	COG0804	urea catabolic process
IE4872_CH03063	COG1442	glycosyl transferase family 8
IE4872_CH03064	COG3755	Protein conserved in bacteria
IE4872_CH03065	COG0832	Belongs to the urease beta subunit family
IE4872_CH03066	COG3813	Protein conserved in bacteria
IE4872_CH03068	COG0829	nickel cation binding
IE4872_CH03072	COG0559	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH03075	COG5002	protein histidine kinase activity
IE4872_CH03075	COG2198	Histidine kinase
IE4872_CH03075	COG0784	Response regulator, receiver
IE4872_CH03076	COG0745	RESPONSE REGULATOR receiver
IE4872_CH03079	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE4872_CH03080	COG0683	leucine binding
IE4872_CH03083	COG0411	ABC transporter
IE4872_CH03085	COG0559	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH03088	COG2020	methyltransferase activity
IE4872_CH03090	COG1218	3'(2'),5'-bisphosphate nucleotidase
IE4872_CH03093	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IE4872_CH03100	COG3047	cAMP biosynthetic process
IE4872_CH03100	COG2885	chlorophyll binding
IE4872_CH03106	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IE4872_CH03122	COG0564	pseudouridine synthase activity
IE4872_CH03123	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IE4872_CH03126	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IE4872_CH03131	COG0346	lactoylglutathione lyase activity
IE4872_CH03132	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IE4872_CH03133	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE4872_CH03134	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IE4872_CH03134	COG0662	Cupin 2, conserved barrel domain protein
IE4872_CH03135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IE4872_CH03136	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE4872_CH03138	COG0129	dihydroxy-acid dehydratase activity
IE4872_CH03140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_CH03146	COG2094	Belongs to the DNA glycosylase MPG family
IE4872_CH03148	COG1566	PFAM secretion protein HlyD family protein
IE4872_CH03150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_CH03152	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_CH03153	COG3307	-O-antigen
IE4872_CH03154	COG1596	polysaccharide export
IE4872_CH03157	COG1215	transferase activity, transferring glycosyl groups
IE4872_CH03158	COG0463	Glycosyl transferase, family 2
IE4872_CH03159	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_CH03160	COG2273	Hydrolase Family 16
IE4872_CH03161	COG1215	transferase activity, transferring glycosyl groups
IE4872_CH03162	COG1215	transferase activity, transferring glycosyl groups
IE4872_CH03163	COG1215	transferase activity, transferring glycosyl groups
IE4872_CH03164	COG0489	protein tyrosine kinase activity
IE4872_CH03164	COG3206	protein involved in exopolysaccharide biosynthesis
IE4872_CH03165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IE4872_CH03167	COG1959	2 iron, 2 sulfur cluster binding
IE4872_CH03168	COG2186	Transcriptional regulator
IE4872_CH03169	COG0747	negative chemotaxis
IE4872_CH03172	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_CH03173	COG0444	Belongs to the ABC transporter superfamily
IE4872_CH03175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_CH03176	COG1063	alcohol dehydrogenase
IE4872_CH03177	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IE4872_CH03179	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE4872_CH03181	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IE4872_CH03182	COG1733	regulation of RNA biosynthetic process
IE4872_CH03186	COG1672	PFAM Archaeal ATPase
IE4872_CH03186	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_CH03190	COG0673	inositol 2-dehydrogenase activity
IE4872_CH03192	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE4872_CH03195	COG2186	Transcriptional regulator
IE4872_CH03197	COG1132	(ABC) transporter
IE4872_CH03201	COG2755	lipolytic protein G-D-S-L family
IE4872_CH03201	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_CH03204	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH03210	COG2755	lipolytic protein G-D-S-L family
IE4872_CH03210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_CH03217	COG1368	sulfuric ester hydrolase activity
IE4872_CH03218	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH03219	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_CH03234	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IE4872_CH03236	COG0583	DNA-binding transcription factor activity
IE4872_CH03240	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_CH03242	COG3842	ATPase activity
IE4872_CH03245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE4872_CH03250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IE4872_CH03253	COG2733	membrane
IE4872_CH03256	COG0745	RESPONSE REGULATOR receiver
IE4872_CH03257	COG3916	Acyl-homoserine-lactone synthase
IE4872_CH03264	COG3505	Type IV secretory pathway VirD4
IE4872_CH03266	COG1129	ABC transporter
IE4872_CH03267	COG1672	PFAM Archaeal ATPase
IE4872_CH03267	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_CH03273	COG2161	toxin-antitoxin pair type II binding
IE4872_CH03279	COG3360	Dodecin
IE4872_CH03289	COG1475	DNA binding
IE4872_CH03294	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IE4872_CH03295	COG2948	multi-organism process
IE4872_CH03296	COG3504	Conjugal transfer protein
IE4872_CH03297	COG3736	Type IV secretory pathway, component VirB8
IE4872_CH03299	COG3704	protein secretion by the type IV secretion system
IE4872_CH03302	COG3451	type IV secretory pathway VirB4
IE4872_CH03303	COG3702	type iv secretory pathway
IE4872_CH03304	COG3838	Conjugal transfer protein Trbc
IE4872_CH03309	COG2080	2 iron, 2 sulfur cluster binding
IE4872_CH03310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IE4872_CH03311	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_CH03313	COG5654	RES domain protein
IE4872_CH03315	COG1283	sodium-dependent phosphate transmembrane transporter activity
IE4872_CH03318	COG1051	belongs to the nudix hydrolase family
IE4872_CH03319	COG3025	triphosphatase activity
IE4872_CH03328	COG1653	transport
IE4872_CH03333	COG0673	inositol 2-dehydrogenase activity
IE4872_CH03335	COG0395	ABC-type sugar transport system, permease component
IE4872_CH03337	COG3842	ATPase activity
IE4872_CH03345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IE4872_CH03346	COG1968	undecaprenyl-diphosphatase activity
IE4872_CH03347	COG0671	phosphoesterase, PA-phosphatase related
IE4872_CH03349	COG3550	peptidyl-serine autophosphorylation
IE4872_CH03353	COG4172	Belongs to the ABC transporter superfamily
IE4872_CH03354	COG4171	peptide transport system, permease
IE4872_CH03355	COG0601	transmembrane transport
IE4872_CH03360	COG0626	cystathionine gamma-synthase activity
IE4872_CH03361	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_CH03362	COG4597	amino acid ABC transporter
IE4872_CH03363	COG0765	amino acid transport
IE4872_CH03364	COG1126	abc transporter atp-binding protein
IE4872_CH03371	COG0745	RESPONSE REGULATOR receiver
IE4872_CH03373	COG2205	protein histidine kinase activity
IE4872_CH03378	COG0745	RESPONSE REGULATOR receiver
IE4872_CH03383	COG3971	2-oxopent-4-enoate hydratase activity
IE4872_CH03384	COG3485	protocatechuate 3,4-dioxygenase
IE4872_CH03385	COG1802	Transcriptional regulator
IE4872_CH03387	COG0765	amino acid transport
IE4872_CH03388	COG0765	amino acid transport
IE4872_CH03389	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_CH03390	COG1126	abc transporter atp-binding protein
IE4872_CH03391	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE4872_CH03393	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IE4872_CH03394	COG0673	inositol 2-dehydrogenase activity
IE4872_CH03402	COG4774	siderophore transport
IE4872_CH03413	COG1846	Transcriptional regulator
IE4872_CH03419	COG0438	transferase activity, transferring glycosyl groups
IE4872_CH03433	COG1187	pseudouridine synthase activity
IE4872_CH03435	COG3273	potassium ion transport
IE4872_CH03435	COG0471	metal ion transport
IE4872_CH03436	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IE4872_CH03437	COG1309	transcriptional regulator
IE4872_CH03438	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_CH03439	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE4872_CH03441	COG1609	Transcriptional regulator
IE4872_CH03443	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_CH03444	COG1177	transmembrane transport
IE4872_CH03447	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IE4872_CH03448	COG1473	amidohydrolase
IE4872_CH03454	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IE4872_CH03458	COG2062	phosphohistidine phosphatase, SixA
IE4872_CH03470	COG0482	sulfurtransferase activity
IE4872_CH03471	COG0668	transmembrane transport
IE4872_CH03475	COG0789	Transcriptional regulator
IE4872_CH03478	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE4872_CH03480	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IE4872_CH03482	COG1845	cytochrome c oxidase, subunit III
IE4872_CH03483	COG1845	cytochrome c oxidase, subunit III
IE4872_CH03484	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IE4872_CH03485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IE4872_CH03486	COG3474	cytochrome
IE4872_CH03487	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE4872_CH03488	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IE4872_CH03489	COG0037	tRNA processing
IE4872_CH03491	COG2885	chlorophyll binding
IE4872_CH03492	COG0823	Involved in the tonB-independent uptake of proteins
IE4872_CH03496	COG0824	Thioesterase
IE4872_CH03501	COG1692	metallophosphoesterase
IE4872_CH03504	COG0217	transcriptional regulatory protein
IE4872_CH03505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_CH03506	COG0840	transmembrane signaling receptor activity
IE4872_CH03507	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IE4872_CH03510	COG0632	four-way junction helicase activity
IE4872_CH03511	COG2255	four-way junction helicase activity
IE4872_CH03512	COG1408	metallophosphoesterase
IE4872_CH03513	COG2318	DinB family
IE4872_CH03516	COG0668	transmembrane transport
IE4872_CH03517	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IE4872_CH03520	COG2814	Major facilitator Superfamily
IE4872_CH03521	COG0583	DNA-binding transcription factor activity
IE4872_CH03529	COG0126	phosphoglycerate kinase activity
IE4872_CH03530	COG3588	fructose-bisphosphate aldolase
IE4872_CH03531	COG0384	phenazine biosynthesis protein PhzF
IE4872_CH03536	COG0254	rRNA binding
IE4872_CH03537	COG1132	(ABC) transporter
IE4872_CH03540	COG3422	double-strand break repair
IE4872_CH03544	COG0483	inositol monophosphate 1-phosphatase activity
IE4872_CH03548	COG0640	Transcriptional regulator
IE4872_CH03551	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IE4872_CH03552	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IE4872_CH03553	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IE4872_CH03554	COG0457	Tetratricopeptide repeat
IE4872_CH03558	COG3708	Transcriptional regulator
IE4872_CH03558	COG2207	Transcriptional regulator
IE4872_CH03560	COG0583	DNA-binding transcription factor activity
IE4872_CH03561	COG1942	4-Oxalocrotonate Tautomerase
IE4872_CH03563	COG1280	lysine exporter protein (LysE YggA)
IE4872_CH03564	COG0469	pyruvate kinase activity
IE4872_CH03568	COG3750	Belongs to the UPF0335 family
IE4872_CH03571	COG3108	Peptidase M15
IE4872_CH03577	COG5310	Homospermidine synthase
IE4872_CH03579	COG0737	Belongs to the 5'-nucleotidase family
IE4872_CH03580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IE4872_CH03581	COG0330	HflC and HflK could
IE4872_CH03585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IE4872_CH03586	COG2951	lytic endotransglycosylase activity
IE4872_CH03591	COG0067	glutamate synthase
IE4872_CH03591	COG0070	glutamate synthase
IE4872_CH03591	COG0069	glutamate synthase activity
IE4872_CH03597	COG0071	Belongs to the small heat shock protein (HSP20) family
IE4872_CH03607	COG1285	pathogenesis
IE4872_CH03618	COG0642	Histidine kinase
IE4872_CH03620	COG2307	Protein conserved in bacteria
IE4872_CH03620	COG2308	Evidence 4 Homologs of previously reported genes of
IE4872_CH03623	COG0058	SHG alpha-glucan phosphorylase activity
IE4872_CH03624	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IE4872_CH03625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IE4872_CH03626	COG0297	glycogen (starch) synthase activity
IE4872_CH03627	COG0033	Phosphoglucomutase
IE4872_CH03628	COG1523	belongs to the glycosyl hydrolase 13 family
IE4872_CH03632	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE4872_CH03632	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IE4872_CH03634	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH03638	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IE4872_CH03640	COG1278	Cold shock
IE4872_CH03641	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IE4872_CH03644	COG3920	Histidine kinase
IE4872_CH03644	COG2202	Pas domain
IE4872_CH03645	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_CH03647	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IE4872_CH03648	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IE4872_CH03649	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IE4872_CH03652	COG5001	Diguanylate cyclase
IE4872_CH03655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IE4872_CH03656	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IE4872_CH03659	COG1609	Transcriptional regulator
IE4872_CH03660	COG1846	Transcriptional regulator
IE4872_CH03662	COG0523	cobalamin synthesis protein
IE4872_CH03666	COG0456	acetyltransferase
IE4872_CH03669	COG0583	DNA-binding transcription factor activity
IE4872_CH03675	COG0800	Aldolase
IE4872_CH03679	COG3300	MHYT domain
IE4872_CH03679	COG5001	Diguanylate cyclase
IE4872_CH03680	COG1464	Belongs to the NlpA lipoprotein family
IE4872_CH03681	COG2011	ABC-type metal ion transport system permease component
IE4872_CH03682	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IE4872_CH03684	COG0673	inositol 2-dehydrogenase activity
IE4872_CH03686	COG1879	ABC-type sugar transport system periplasmic component
IE4872_CH03687	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH03688	COG1129	ABC transporter
IE4872_CH03689	COG1609	Transcriptional regulator
IE4872_CH03690	COG2115	Belongs to the xylose isomerase family
IE4872_CH03691	COG1070	Carbohydrate kinase
IE4872_CH03692	COG1609	Transcriptional regulator
IE4872_CH03695	COG1309	transcriptional regulator
IE4872_CH03697	COG1253	flavin adenine dinucleotide binding
IE4872_CH03699	COG3273	potassium ion transport
IE4872_CH03699	COG0471	metal ion transport
IE4872_CH03701	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IE4872_CH03702	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IE4872_CH03704	COG0583	DNA-binding transcription factor activity
IE4872_CH03705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IE4872_CH03706	COG3842	ATPase activity
IE4872_CH03707	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_CH03708	COG1177	transmembrane transport
IE4872_CH03712	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IE4872_CH03714	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE4872_CH03724	COG1175	transmembrane transport
IE4872_CH03726	COG2390	Transcriptional regulator
IE4872_CH03728	COG0745	RESPONSE REGULATOR receiver
IE4872_CH03729	COG0642	Histidine kinase
IE4872_CH03730	COG1940	carbohydrate kinase activity
IE4872_CH03734	COG1764	response to oxidative stress
IE4872_CH03735	COG2186	Transcriptional regulator
IE4872_CH03736	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_CH03738	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH03739	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_CH03742	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH03745	COG3842	ATPase activity
IE4872_CH03746	COG0395	ABC-type sugar transport system, permease component
IE4872_CH03748	COG1653	transport
IE4872_CH03750	COG0392	lysyltransferase activity
IE4872_CH03755	COG0395	ABC-type sugar transport system, permease component
IE4872_CH03757	COG3842	ATPase activity
IE4872_CH03758	COG3842	ATPase activity
IE4872_CH03760	COG0673	inositol 2-dehydrogenase activity
IE4872_CH03766	COG4191	Histidine kinase
IE4872_CH03767	COG4566	intracellular signal transduction
IE4872_CH03769	COG4566	intracellular signal transduction
IE4872_CH03772	COG3395	kinase activity
IE4872_CH03773	COG3622	Belongs to the hyi family
IE4872_CH03774	COG2084	Dehydrogenase
IE4872_CH03776	COG1609	Transcriptional regulator
IE4872_CH03784	COG0542	response to heat
IE4872_CH03785	COG1280	lysine exporter protein (LysE YggA)
IE4872_CH03787	COG2890	protein-(glutamine-N5) methyltransferase activity
IE4872_CH03788	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IE4872_CH03789	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
IE4872_CH03790	COG0527	aspartate kinase activity
IE4872_CH03792	COG2323	membrane
IE4872_CH03796	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IE4872_CH03798	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE4872_CH03799	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IE4872_CH03801	COG2226	methyltransferase
IE4872_CH03804	COG0494	nUDIX hydrolase
IE4872_CH03805	COG0456	acetyltransferase
IE4872_CH03806	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IE4872_CH03807	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE4872_CH03808	COG0653	protein targeting
IE4872_CH03811	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IE4872_CH03812	COG0667	Aldo Keto reductase
IE4872_CH03821	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE4872_CH03821	COG4651	solute:proton antiporter activity
IE4872_CH03827	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IE4872_CH03829	COG0300	oxidoreductase activity
IE4872_CH03833	COG2086	electron transfer activity
IE4872_CH03834	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IE4872_CH03835	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE4872_CH03836	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IE4872_CH03837	COG0165	Argininosuccinate lyase
IE4872_CH03844	COG2884	Cell division ATP-binding protein ftsE
IE4872_CH03848	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IE4872_CH03850	COG0287	Prephenate dehydrogenase
IE4872_CH03851	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IE4872_CH03852	COG2226	methyltransferase
IE4872_CH03853	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_CH03857	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IE4872_CH03865	COG4536	flavin adenine dinucleotide binding
IE4872_CH03866	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IE4872_CH03867	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IE4872_CH03869	COG4974	Belongs to the 'phage' integrase family
IE4872_CH03870	COG0825	malonyl-CoA metabolic process
IE4872_CH03871	COG3034	peptidoglycan biosynthetic process
IE4872_CH03873	COG0523	cobalamin synthesis protein
IE4872_CH03874	COG1686	Belongs to the peptidase S11 family
IE4872_CH03877	COG2719	SpoVR family
IE4872_CH03878	COG2718	Belongs to the UPF0229 family
IE4872_CH03879	COG2766	serine protein kinase
IE4872_CH03884	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IE4872_CH03885	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_CH03894	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IE4872_CH03895	COG0835	chemotaxis
IE4872_CH03898	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IE4872_CH03899	COG3383	formate dehydrogenase (NAD+) activity
IE4872_CH03902	COG0583	DNA-binding transcription factor activity
IE4872_CH03903	COG0640	Transcriptional regulator
IE4872_CH03904	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH03908	COG0789	Transcriptional regulator
IE4872_CH03911	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IE4872_CH03913	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IE4872_CH03914	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IE4872_CH03915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IE4872_CH03916	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IE4872_CH03921	COG4974	Belongs to the 'phage' integrase family
IE4872_CH03924	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH03926	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE4872_CH03929	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IE4872_CH03930	COG0045	succinate-CoA ligase (ADP-forming) activity
IE4872_CH03931	COG0039	L-malate dehydrogenase activity
IE4872_CH03932	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IE4872_CH03933	COG2845	Protein of unknown function (DUF459)
IE4872_CH03943	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IE4872_CH03944	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IE4872_CH03945	COG0181	hydroxymethylbilane synthase activity
IE4872_CH03952	COG1872	DUF167
IE4872_CH03953	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IE4872_CH03957	COG0339	signal peptide processing
IE4872_CH03960	COG0137	argininosuccinate synthase activity
IE4872_CH03963	COG0410	ABC transporter
IE4872_CH03964	COG4120	Belongs to the binding-protein-dependent transport system permease family
IE4872_CH03966	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IE4872_CH03970	COG2154	pterin-4-alpha-carbinolamine dehydratase
IE4872_CH03971	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IE4872_CH03973	COG4181	ATPase activity
IE4872_CH03975	COG0670	Belongs to the BI1 family
IE4872_CH03979	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IE4872_CH03981	COG4133	protoheme IX ABC transporter activity
IE4872_CH03982	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IE4872_CH03983	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IE4872_CH03987	COG2917	probably involved in intracellular septation
IE4872_CH03988	COG0552	protein localization to endoplasmic reticulum
IE4872_CH03989	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IE4872_CH03990	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IE4872_CH03991	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IE4872_CH03992	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IE4872_CH03993	COG0287	Prephenate dehydrogenase
IE4872_CH03993	COG1605	Chorismate mutase
IE4872_CH03994	COG0228	four-way junction DNA binding
IE4872_CH03995	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IE4872_CH03996	COG0336	Belongs to the RNA methyltransferase TrmD family
IE4872_CH03997	COG0335	large ribosomal subunit rRNA binding
IE4872_CH03999	COG0765	amino acid transport
IE4872_CH04001	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IE4872_CH04005	COG0745	RESPONSE REGULATOR receiver
IE4872_CH04007	COG0708	Exodeoxyribonuclease III
IE4872_CH04008	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IE4872_CH04009	COG1674	ftsk spoiiie
IE4872_CH04010	COG0004	ammonium transporteR
IE4872_CH04011	COG0347	Belongs to the P(II) protein family
IE4872_CH04012	COG1946	Acyl-CoA thioesterase
IE4872_CH04013	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE4872_CH04014	COG2835	tetraacyldisaccharide 4'-kinase activity
IE4872_CH04016	COG3118	belongs to the thioredoxin family
IE4872_CH04022	COG3842	ATPase activity
IE4872_CH04025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IE4872_CH04026	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_CH04027	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_CH04036	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IE4872_CH04038	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE4872_CH04040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IE4872_CH04041	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IE4872_CH04042	COG4821	SIS domain
IE4872_CH04043	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IE4872_CH04044	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE4872_CH04045	COG2188	Transcriptional regulator
IE4872_CH04047	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IE4872_CH04048	COG4178	(ABC) transporter
IE4872_CH04053	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IE4872_CH04054	COG4783	chaperone-mediated protein folding
IE4872_CH04055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IE4872_CH04056	COG1329	Transcriptional regulator
IE4872_CH04061	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_CH04062	COG0183	Belongs to the thiolase family
IE4872_CH04063	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IE4872_CH04065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IE4872_CH04067	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IE4872_CH04069	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IE4872_CH04070	COG2223	nitrite transmembrane transporter activity
IE4872_CH04071	COG1349	DNA-binding transcription factor activity
IE4872_CH04072	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_CH04073	COG0765	amino acid transport
IE4872_CH04074	COG1126	abc transporter atp-binding protein
IE4872_CH04077	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IE4872_CH04079	COG1132	(ABC) transporter
IE4872_CH04084	COG3459	Glycosyltransferase 36 associated
IE4872_CH04087	COG4608	Belongs to the ABC transporter superfamily
IE4872_CH04088	COG0444	Belongs to the ABC transporter superfamily
IE4872_CH04090	COG0601	transmembrane transport
IE4872_CH04091	COG0747	negative chemotaxis
IE4872_CH04100	COG3706	GGDEF domain
IE4872_CH04105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IE4872_CH04106	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IE4872_CH04110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IE4872_CH04111	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IE4872_CH04112	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IE4872_CH04113	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IE4872_CH04114	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_CH04119	COG0725	ABC transporter, periplasmic molybdate-binding protein
IE4872_CH04120	COG4149	molybdate abc transporter
IE4872_CH04121	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IE4872_CH04123	COG0799	negative regulation of ribosome biogenesis
IE4872_CH04124	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IE4872_CH04126	COG0793	Belongs to the peptidase S41A family
IE4872_CH04128	COG0494	nUDIX hydrolase
IE4872_CH04129	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IE4872_CH04134	COG0587	DNA-directed DNA polymerase activity
IE4872_CH04135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE4872_CH04139	COG2301	Belongs to the HpcH HpaI aldolase family
IE4872_CH04141	COG0066	3-isopropylmalate dehydratase activity
IE4872_CH04142	COG0473	3-isopropylmalate dehydrogenase activity
IE4872_CH04143	COG0671	phosphoesterase, PA-phosphatase related
IE4872_CH04145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE4872_CH04147	COG0288	reversible hydration of carbon dioxide
IE4872_CH04148	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IE4872_CH04149	COG2902	Dehydrogenase
IE4872_CH04150	COG2270	Major facilitator Superfamily
IE4872_CH04151	COG0138	bifunctional purine biosynthesis protein purh
IE4872_CH04154	COG0501	Belongs to the peptidase M48B family
IE4872_CH04156	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IE4872_CH04161	COG0495	leucyl-tRNA aminoacylation
IE4872_CH04164	COG1475	DNA binding
IE4872_CH04165	COG1192	Involved in chromosome partitioning
IE4872_CH04166	COG0357	Ribosomal RNA small subunit methyltransferase G
IE4872_CH04167	COG0445	tRNA wobble uridine modification
IE4872_CH04168	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IE4872_CH04169	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IE4872_CH04171	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IE4872_PA00006	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IE4872_PA00013	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IE4872_PA00031	COG5489	Protein of unknown function (DUF736)
IE4872_PA00034	COG0318	PFAM AMP-dependent synthetase and ligase
IE4872_PA00037	COG2271	Major facilitator Superfamily
IE4872_PA00038	COG0583	DNA-binding transcription factor activity
IE4872_PA00049	COG4959	Type IV secretory pathway protease TraF
IE4872_PA00055	COG2086	electron transfer activity
IE4872_PA00056	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IE4872_PA00058	COG1960	acyl-CoA dehydrogenase activity
IE4872_PA00063	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PA00068	COG2186	Transcriptional regulator
IE4872_PA00070	COG1802	Transcriptional regulator
IE4872_PA00071	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IE4872_PA00072	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IE4872_PA00073	COG4770	biotin carboxylase activity
IE4872_PA00075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IE4872_PA00078	COG1126	abc transporter atp-binding protein
IE4872_PA00081	COG0765	amino acid transport
IE4872_PA00082	COG0765	amino acid transport
IE4872_PA00083	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PA00087	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE4872_PA00096	COG2801	Transposase and inactivated derivatives
IE4872_PA00101	COG3321	synthase
IE4872_PA00101	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PA00101	COG0604	alcohol dehydrogenase
IE4872_PA00102	COG2963	transposase activity
IE4872_PA00105	COG1802	Transcriptional regulator
IE4872_PA00107	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IE4872_PA00108	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE4872_PA00109	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IE4872_PA00110	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_PA00111	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IE4872_PA00114	COG0439	Biotin carboxylase
IE4872_PA00115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IE4872_PA00116	COG3800	Transcriptional regulator
IE4872_PA00116	COG1396	sequence-specific DNA binding
IE4872_PA00120	COG3701	Conjugal transfer protein
IE4872_PA00123	COG5314	conjugation
IE4872_PA00124	COG3451	type IV secretory pathway VirB4
IE4872_PA00127	COG4962	Type ii secretion system protein e
IE4872_PA00129	COG1192	Involved in chromosome partitioning
IE4872_PA00130	COG1475	DNA binding
IE4872_PA00131	COG0640	Transcriptional regulator
IE4872_PB00003	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE4872_PB00006	COG1074	ATP-dependent DNA helicase activity
IE4872_PB00009	COG0210	DNA helicase
IE4872_PB00022	COG0235	Class ii aldolase
IE4872_PB00023	COG3395	kinase activity
IE4872_PB00024	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PB00027	COG0473	3-isopropylmalate dehydrogenase activity
IE4872_PB00029	COG1088	dTDP-glucose 4,6-dehydratase activity
IE4872_PB00030	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00031	COG1129	ABC transporter
IE4872_PB00032	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PB00034	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IE4872_PB00038	COG2186	Transcriptional regulator
IE4872_PB00041	COG3246	L-lysine catabolic process to acetate
IE4872_PB00042	COG1129	ABC transporter
IE4872_PB00043	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00044	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PB00046	COG1850	ribulose-bisphosphate carboxylase activity
IE4872_PB00047	COG0667	Aldo Keto reductase
IE4872_PB00048	COG0009	L-threonylcarbamoyladenylate synthase
IE4872_PB00051	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_PB00055	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PB00056	COG0300	oxidoreductase activity
IE4872_PB00057	COG4221	oxidoreductase activity
IE4872_PB00058	COG0583	DNA-binding transcription factor activity
IE4872_PB00059	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE4872_PB00062	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PB00063	COG1129	ABC transporter
IE4872_PB00064	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00066	COG1069	ribulokinase activity
IE4872_PB00067	COG0583	DNA-binding transcription factor activity
IE4872_PB00068	COG2188	Transcriptional regulator
IE4872_PB00072	COG0596	Alpha beta hydrolase
IE4872_PB00073	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PB00074	COG1129	ABC transporter
IE4872_PB00075	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00076	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00080	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PB00081	COG1129	ABC transporter
IE4872_PB00082	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00083	COG4211	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00086	COG1252	NADH dehydrogenase
IE4872_PB00089	COG0840	transmembrane signaling receptor activity
IE4872_PB00089	COG2972	Histidine kinase
IE4872_PB00090	COG4213	ABC transporter substrate-binding protein
IE4872_PB00091	COG2801	Transposase and inactivated derivatives
IE4872_PB00092	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IE4872_PB00095	COG0840	transmembrane signaling receptor activity
IE4872_PB00098	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE4872_PB00100	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PB00102	COG1129	ABC transporter
IE4872_PB00105	COG0436	Aminotransferase
IE4872_PB00106	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PB00108	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE4872_PB00109	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE4872_PB00110	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PB00112	COG0596	Alpha beta hydrolase
IE4872_PB00113	COG2188	Transcriptional regulator
IE4872_PB00115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IE4872_PB00117	COG0840	transmembrane signaling receptor activity
IE4872_PB00117	COG2972	Histidine kinase
IE4872_PB00123	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_PB00127	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE4872_PB00128	COG2084	Dehydrogenase
IE4872_PB00130	COG0583	DNA-binding transcription factor activity
IE4872_PB00132	COG2376	Dihydroxyacetone kinase
IE4872_PB00148	COG5489	Protein of unknown function (DUF736)
IE4872_PB00154	COG3831	ATPase activity
IE4872_PB00156	COG3505	Type IV secretory pathway VirD4
IE4872_PB00159	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE4872_PB00160	COG4962	Type ii secretion system protein e
IE4872_PB00161	COG3916	Acyl-homoserine-lactone synthase
IE4872_PB00162	COG1192	Involved in chromosome partitioning
IE4872_PB00163	COG1475	DNA binding
IE4872_PB00165	COG0640	Transcriptional regulator
IE4872_PC00004	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE4872_PC00037	COG3328	transposase activity
IE4872_PC00045	COG2390	Transcriptional regulator
IE4872_PC00045	COG4584	PFAM Integrase catalytic
IE4872_PC00053	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_PC00073	COG0840	transmembrane signaling receptor activity
IE4872_PC00073	COG2972	Histidine kinase
IE4872_PC00074	COG1278	Cold shock
IE4872_PC00078	COG1175	transmembrane transport
IE4872_PC00079	COG1653	transport
IE4872_PC00080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IE4872_PC00083	COG3550	peptidyl-serine autophosphorylation
IE4872_PC00085	COG2963	transposase activity
IE4872_PC00087	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PC00090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IE4872_PC00091	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE4872_PC00093	COG2971	BadF BadG BcrA BcrD
IE4872_PC00096	COG1940	carbohydrate kinase activity
IE4872_PC00099	COG0395	ABC-type sugar transport system, permease component
IE4872_PC00106	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE4872_PC00108	COG1940	carbohydrate kinase activity
IE4872_PC00111	COG3831	ATPase activity
IE4872_PC00113	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IE4872_PC00114	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IE4872_PC00118	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00119	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00120	COG1473	amidohydrolase
IE4872_PC00122	COG1126	abc transporter atp-binding protein
IE4872_PC00125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00140	COG0612	Peptidase, M16
IE4872_PC00141	COG0612	Peptidase, M16
IE4872_PC00148	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_PC00148	COG2755	lipolytic protein G-D-S-L family
IE4872_PC00154	COG0612	Peptidase, M16
IE4872_PC00155	COG2072	flavoprotein involved in K transport
IE4872_PC00163	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE4872_PC00168	COG1278	Cold shock
IE4872_PC00171	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE4872_PC00182	COG3383	formate dehydrogenase (NAD+) activity
IE4872_PC00183	COG5420	small protein containing a coiled-coil domain
IE4872_PC00194	COG3047	cAMP biosynthetic process
IE4872_PC00195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE4872_PC00209	COG0726	polysaccharide deacetylase
IE4872_PC00215	COG0667	Aldo Keto reductase
IE4872_PC00217	COG0175	sulfate reduction
IE4872_PC00219	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IE4872_PC00220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00234	COG5554	nitrogen fixation
IE4872_PC00235	COG5554	nitrogen fixation
IE4872_PC00236	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE4872_PC00237	COG0535	radical SAM domain protein
IE4872_PC00240	COG0644	oxidoreductase
IE4872_PC00241	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IE4872_PC00250	COG1104	cysteine desulfurase activity
IE4872_PC00252	COG0316	Belongs to the HesB IscA family
IE4872_PC00255	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IE4872_PC00260	COG2226	methyltransferase
IE4872_PC00266	COG4778	phosphonate C-P lyase system protein PhnL
IE4872_PC00267	COG3454	Phosphonate metabolism
IE4872_PC00268	COG4107	phosphonate C-P lyase system protein PhnK
IE4872_PC00269	COG3627	carbon phosphorus lyase activity
IE4872_PC00270	COG3626	phosphonate metabolism
IE4872_PC00271	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IE4872_PC00272	COG3624	Phosphonate C-P lyase system protein PhnG
IE4872_PC00275	COG4608	Belongs to the ABC transporter superfamily
IE4872_PC00278	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PC00279	COG0601	transmembrane transport
IE4872_PC00282	COG1213	nucleotidyl transferase
IE4872_PC00284	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IE4872_PC00287	COG2124	cytochrome p450
IE4872_PC00289	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IE4872_PC00290	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PC00291	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00295	COG2433	Pfam Transposase IS66
IE4872_PC00297	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IE4872_PC00298	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IE4872_PC00299	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IE4872_PC00300	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IE4872_PC00301	COG1433	Dinitrogenase iron-molybdenum cofactor
IE4872_PC00303	COG5420	small protein containing a coiled-coil domain
IE4872_PC00304	COG3383	formate dehydrogenase (NAD+) activity
IE4872_PC00306	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE4872_PC00308	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IE4872_PC00311	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IE4872_PC00315	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
IE4872_PC00320	COG0582	viral genome integration into host DNA
IE4872_PC00324	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE4872_PC00326	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_PC00327	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_PC00329	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IE4872_PC00335	COG2211	Major facilitator Superfamily
IE4872_PC00338	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IE4872_PC00339	COG2771	luxR family
IE4872_PC00342	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE4872_PC00345	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE4872_PC00347	COG4264	IucA IucC family
IE4872_PC00348	COG2801	Transposase and inactivated derivatives
IE4872_PC00349	COG0587	DNA-directed DNA polymerase activity
IE4872_PC00351	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_PC00352	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PC00353	COG0251	oxidation-reduction process
IE4872_PC00354	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_PC00355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE4872_PC00356	COG1522	sequence-specific DNA binding
IE4872_PC00357	COG1770	oligopeptidase
IE4872_PC00358	COG4608	Belongs to the ABC transporter superfamily
IE4872_PC00359	COG0444	Belongs to the ABC transporter superfamily
IE4872_PC00360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PC00361	COG0601	transmembrane transport
IE4872_PC00362	COG0747	negative chemotaxis
IE4872_PC00366	COG0154	amidase activity
IE4872_PC00371	COG0154	amidase activity
IE4872_PC00373	COG1126	abc transporter atp-binding protein
IE4872_PC00374	COG0765	amino acid transport
IE4872_PC00375	COG0765	amino acid transport
IE4872_PC00378	COG1522	sequence-specific DNA binding
IE4872_PC00379	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PC00380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PC00381	COG0765	amino acid transport
IE4872_PC00382	COG0765	amino acid transport
IE4872_PC00383	COG1126	abc transporter atp-binding protein
IE4872_PC00386	COG1473	amidohydrolase
IE4872_PC00387	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE4872_PC00388	COG2423	ornithine cyclodeaminase activity
IE4872_PC00389	COG0006	proline dipeptidase activity
IE4872_PC00390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE4872_PC00391	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PC00392	COG1027	Aspartate ammonia-lyase
IE4872_PC00399	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE4872_PC00403	COG5328	Belongs to the UPF0262 family
IE4872_PC00404	COG2801	Transposase and inactivated derivatives
IE4872_PC00405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IE4872_PC00407	COG2801	Transposase and inactivated derivatives
IE4872_PC00408	COG2826	transposase and inactivated derivatives, IS30 family
IE4872_PC00411	COG2826	transposase and inactivated derivatives, IS30 family
IE4872_PC00413	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IE4872_PC00414	COG2801	Transposase and inactivated derivatives
IE4872_PC00421	COG2124	cytochrome p450
IE4872_PC00422	COG2124	cytochrome p450
IE4872_PC00423	COG2124	cytochrome p450
IE4872_PC00424	COG1141	Ferredoxin
IE4872_PC00425	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PC00426	COG2124	cytochrome p450
IE4872_PC00427	COG0142	geranyltranstransferase activity
IE4872_PC00428	COG1657	PFAM Prenyltransferase squalene oxidase
IE4872_PC00438	COG0747	negative chemotaxis
IE4872_PC00444	COG0431	NADPH-dependent FMN reductase
IE4872_PC00446	COG2011	ABC-type metal ion transport system permease component
IE4872_PC00448	COG1464	Belongs to the NlpA lipoprotein family
IE4872_PC00452	COG2011	ABC-type metal ion transport system permease component
IE4872_PC00453	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IE4872_PC00454	COG1464	Belongs to the NlpA lipoprotein family
IE4872_PC00455	COG1959	2 iron, 2 sulfur cluster binding
IE4872_PC00457	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00459	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_PC00465	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PC00466	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PC00467	COG1129	ABC transporter
IE4872_PC00470	COG1129	ABC transporter
IE4872_PC00471	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PC00472	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PC00473	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE4872_PC00474	COG0183	Belongs to the thiolase family
IE4872_PC00475	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_PC00476	COG2814	Major facilitator Superfamily
IE4872_PC00479	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_PC00488	COG5489	Protein of unknown function (DUF736)
IE4872_PC00492	COG2203	Gaf domain
IE4872_PC00492	COG5001	Diguanylate cyclase
IE4872_PC00492	COG4251	negative regulation of phosphorylation
IE4872_PC00492	COG3706	GGDEF domain
IE4872_PC00493	COG0784	Response regulator, receiver
IE4872_PC00493	COG4191	Histidine kinase
IE4872_PC00494	COG3831	ATPase activity
IE4872_PC00500	COG0659	secondary active sulfate transmembrane transporter activity
IE4872_PC00502	COG2824	Alkylphosphonate utilization operon protein PhnA
IE4872_PC00503	COG3505	Type IV secretory pathway VirD4
IE4872_PC00506	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE4872_PC00507	COG4959	Type IV secretory pathway protease TraF
IE4872_PC00508	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE4872_PC00512	COG1476	TRANSCRIPTIONal
IE4872_PC00514	COG2771	luxR family
IE4872_PC00515	COG2948	multi-organism process
IE4872_PC00517	COG3504	Conjugal transfer protein
IE4872_PC00518	COG3701	Conjugal transfer protein
IE4872_PC00519	COG3846	protein secretion by the type IV secretion system
IE4872_PC00521	COG5314	conjugation
IE4872_PC00522	COG3451	type IV secretory pathway VirB4
IE4872_PC00523	COG5268	conjugation
IE4872_PC00524	COG3838	Conjugal transfer protein Trbc
IE4872_PC00525	COG4962	Type ii secretion system protein e
IE4872_PC00526	COG3916	Acyl-homoserine-lactone synthase
IE4872_PC00528	COG1192	Involved in chromosome partitioning
IE4872_PC00529	COG1475	DNA binding
IE4872_PC00530	COG0640	Transcriptional regulator
IE4872_PD00001	COG1120	ATPase activity
IE4872_PD00002	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE4872_PD00009	COG3685	Protein conserved in bacteria
IE4872_PD00013	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IE4872_PD00014	COG0494	nUDIX hydrolase
IE4872_PD00016	COG1522	sequence-specific DNA binding
IE4872_PD00019	COG2205	protein histidine kinase activity
IE4872_PD00019	COG2202	Pas domain
IE4872_PD00024	COG3177	Filamentation induced by cAMP protein fic
IE4872_PD00025	COG0583	DNA-binding transcription factor activity
IE4872_PD00029	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00038	COG1228	amidohydrolase
IE4872_PD00041	COG0346	lactoylglutathione lyase activity
IE4872_PD00042	COG0583	DNA-binding transcription factor activity
IE4872_PD00044	COG1733	regulation of RNA biosynthetic process
IE4872_PD00046	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE4872_PD00048	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00049	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE4872_PD00049	COG0475	glutathione-regulated potassium exporter activity
IE4872_PD00050	COG0460	homoserine dehydrogenase
IE4872_PD00051	COG0604	alcohol dehydrogenase
IE4872_PD00051	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00051	COG3321	synthase
IE4872_PD00054	COG1335	isochorismatase
IE4872_PD00057	COG1741	Belongs to the pirin family
IE4872_PD00062	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IE4872_PD00067	COG3842	ATPase activity
IE4872_PD00070	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00071	COG1609	Transcriptional regulator
IE4872_PD00073	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_PD00075	COG0745	RESPONSE REGULATOR receiver
IE4872_PD00076	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_PD00079	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_PD00080	COG3842	ATPase activity
IE4872_PD00082	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IE4872_PD00083	COG0028	Belongs to the TPP enzyme family
IE4872_PD00084	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00087	COG1278	Cold shock
IE4872_PD00093	COG5489	Protein of unknown function (DUF736)
IE4872_PD00104	COG1522	sequence-specific DNA binding
IE4872_PD00107	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IE4872_PD00114	COG0741	lytic transglycosylase activity
IE4872_PD00115	COG3451	type IV secretory pathway VirB4
IE4872_PD00117	COG3838	Conjugal transfer protein Trbc
IE4872_PD00131	COG1401	restriction endodeoxyribonuclease activity
IE4872_PD00133	COG0318	PFAM AMP-dependent synthetase and ligase
IE4872_PD00136	COG2086	electron transfer activity
IE4872_PD00137	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IE4872_PD00140	COG1024	Enoyl-CoA hydratase
IE4872_PD00141	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00143	COG0583	DNA-binding transcription factor activity
IE4872_PD00146	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00152	COG2267	carboxylic ester hydrolase activity
IE4872_PD00154	COG0697	spore germination
IE4872_PD00155	COG1024	Enoyl-CoA hydratase
IE4872_PD00157	COG1414	Transcriptional regulator
IE4872_PD00162	COG3718	enzyme involved in inositol metabolism
IE4872_PD00164	COG1024	Enoyl-CoA hydratase
IE4872_PD00165	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00166	COG2814	Major facilitator Superfamily
IE4872_PD00167	COG1960	acyl-CoA dehydrogenase activity
IE4872_PD00168	COG1960	acyl-CoA dehydrogenase activity
IE4872_PD00171	COG0411	ABC transporter
IE4872_PD00173	COG4221	oxidoreductase activity
IE4872_PD00180	COG1053	succinate dehydrogenase
IE4872_PD00182	COG1053	succinate dehydrogenase
IE4872_PD00191	COG3181	Tripartite tricarboxylate transporter family receptor
IE4872_PD00198	COG1136	(ABC) transporter
IE4872_PD00200	COG1566	PFAM secretion protein HlyD family protein
IE4872_PD00205	COG0745	RESPONSE REGULATOR receiver
IE4872_PD00206	COG5000	phosphorelay sensor kinase activity
IE4872_PD00206	COG5002	protein histidine kinase activity
IE4872_PD00209	COG0277	FAD linked oxidase domain protein
IE4872_PD00213	COG0583	DNA-binding transcription factor activity
IE4872_PD00216	COG0765	amino acid transport
IE4872_PD00217	COG0765	amino acid transport
IE4872_PD00218	COG1126	abc transporter atp-binding protein
IE4872_PD00222	COG3220	belongs to the UPF0276 family
IE4872_PD00231	COG3293	Transposase
IE4872_PD00234	COG1335	isochorismatase
IE4872_PD00236	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IE4872_PD00246	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IE4872_PD00247	COG1228	amidohydrolase
IE4872_PD00249	COG1177	transmembrane transport
IE4872_PD00250	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_PD00251	COG3842	ATPase activity
IE4872_PD00252	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE4872_PD00256	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PD00257	COG0583	DNA-binding transcription factor activity
IE4872_PD00258	COG2072	flavoprotein involved in K transport
IE4872_PD00261	COG2086	electron transfer activity
IE4872_PD00269	COG0410	ABC transporter
IE4872_PD00272	COG2159	amidohydrolase
IE4872_PD00274	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IE4872_PD00277	COG0633	Ferredoxin
IE4872_PD00278	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IE4872_PD00280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IE4872_PD00288	COG3791	Glutathione-dependent formaldehyde-activating
IE4872_PD00292	COG1309	transcriptional regulator
IE4872_PD00295	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00298	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE4872_PD00305	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00306	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_PD00307	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_PD00308	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD00310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE4872_PD00312	COG3842	ATPase activity
IE4872_PD00315	COG1175	transmembrane transport
IE4872_PD00319	COG5564	TIM-barrel signal transduction protein
IE4872_PD00324	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IE4872_PD00325	COG1454	alcohol dehydrogenase
IE4872_PD00329	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PD00330	COG5383	Protein conserved in bacteria
IE4872_PD00331	COG0583	DNA-binding transcription factor activity
IE4872_PD00332	COG0840	transmembrane signaling receptor activity
IE4872_PD00332	COG2972	Histidine kinase
IE4872_PD00333	COG1609	Transcriptional regulator
IE4872_PD00335	COG1129	ABC transporter
IE4872_PD00336	COG4211	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD00338	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_PD00339	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00342	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00344	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00345	COG1609	Transcriptional regulator
IE4872_PD00348	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00352	COG1177	transmembrane transport
IE4872_PD00354	COG1063	alcohol dehydrogenase
IE4872_PD00359	COG0419	ATPase involved in DNA repair
IE4872_PD00360	COG0019	diaminopimelate decarboxylase activity
IE4872_PD00362	COG0583	DNA-binding transcription factor activity
IE4872_PD00365	COG2226	methyltransferase
IE4872_PD00368	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE4872_PD00369	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE4872_PD00369	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE4872_PD00369	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE4872_PD00376	COG1940	carbohydrate kinase activity
IE4872_PD00377	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE4872_PD00380	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00383	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00386	COG1349	DNA-binding transcription factor activity
IE4872_PD00387	COG1830	Aldolase
IE4872_PD00388	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_PD00392	COG1175	transmembrane transport
IE4872_PD00393	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00396	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_PD00396	COG2010	Cytochrome c
IE4872_PD00401	COG0745	RESPONSE REGULATOR receiver
IE4872_PD00402	COG2205	protein histidine kinase activity
IE4872_PD00405	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD00406	COG1129	ABC transporter
IE4872_PD00407	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PD00408	COG4585	Histidine kinase
IE4872_PD00410	COG2885	chlorophyll binding
IE4872_PD00412	COG0861	Integral membrane protein TerC family
IE4872_PD00420	COG0583	DNA-binding transcription factor activity
IE4872_PD00423	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_PD00431	COG1741	Belongs to the pirin family
IE4872_PD00432	COG0477	Major facilitator Superfamily
IE4872_PD00435	COG1278	Cold shock
IE4872_PD00439	COG0698	ribose 5-phosphate isomerase
IE4872_PD00440	COG0149	triose-phosphate isomerase activity
IE4872_PD00441	COG1349	DNA-binding transcription factor activity
IE4872_PD00447	COG1129	ABC transporter
IE4872_PD00448	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD00449	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PD00450	COG1349	DNA-binding transcription factor activity
IE4872_PD00452	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IE4872_PD00455	COG1522	sequence-specific DNA binding
IE4872_PD00457	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PD00458	COG4215	(ABC) transporter
IE4872_PD00464	COG1304	FMN binding
IE4872_PD00474	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD00476	COG0667	Aldo Keto reductase
IE4872_PD00477	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IE4872_PD00479	COG1070	Carbohydrate kinase
IE4872_PD00489	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IE4872_PD00499	COG0776	regulation of translation
IE4872_PD00500	COG2080	2 iron, 2 sulfur cluster binding
IE4872_PD00501	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IE4872_PD00502	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_PD00504	COG0583	DNA-binding transcription factor activity
IE4872_PD00516	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE4872_PD00518	COG0402	S-adenosylhomocysteine deaminase activity
IE4872_PD00520	COG1116	anion transmembrane transporter activity
IE4872_PD00530	COG0625	glutathione transferase activity
IE4872_PD00535	COG0071	Belongs to the small heat shock protein (HSP20) family
IE4872_PD00538	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IE4872_PD00539	COG3665	Urea carboxylase-associated protein
IE4872_PD00548	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00552	COG1609	Transcriptional regulator
IE4872_PD00553	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PD00555	COG0765	amino acid transport
IE4872_PD00557	COG1609	Transcriptional regulator
IE4872_PD00559	COG2084	Dehydrogenase
IE4872_PD00560	COG3265	gluconokinase activity
IE4872_PD00561	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00563	COG1063	alcohol dehydrogenase
IE4872_PD00566	COG1396	sequence-specific DNA binding
IE4872_PD00571	COG2197	response regulator
IE4872_PD00572	COG2267	carboxylic ester hydrolase activity
IE4872_PD00573	COG0601	transmembrane transport
IE4872_PD00574	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD00575	COG4172	Belongs to the ABC transporter superfamily
IE4872_PD00587	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00590	COG4566	intracellular signal transduction
IE4872_PD00595	COG4191	Histidine kinase
IE4872_PD00601	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00602	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_PD00604	COG3842	ATPase activity
IE4872_PD00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_PD00606	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_PD00608	COG0366	Alpha amylase catalytic
IE4872_PD00609	COG0366	Alpha amylase catalytic
IE4872_PD00610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IE4872_PD00611	COG5001	Diguanylate cyclase
IE4872_PD00612	COG2197	response regulator
IE4872_PD00614	COG1940	carbohydrate kinase activity
IE4872_PD00616	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00617	COG1175	transmembrane transport
IE4872_PD00619	COG2207	Transcriptional regulator
IE4872_PD00619	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IE4872_PD00620	COG1486	melibiose metabolic process
IE4872_PD00621	COG0747	negative chemotaxis
IE4872_PD00622	COG0601	transmembrane transport
IE4872_PD00623	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD00624	COG4172	Belongs to the ABC transporter superfamily
IE4872_PD00625	COG1486	melibiose metabolic process
IE4872_PD00628	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_PD00629	COG3842	ATPase activity
IE4872_PD00632	COG0583	DNA-binding transcription factor activity
IE4872_PD00633	COG0436	Aminotransferase
IE4872_PD00635	COG0625	glutathione transferase activity
IE4872_PD00637	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IE4872_PD00640	COG0459	protein refolding
IE4872_PD00641	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IE4872_PD00643	COG0667	Aldo Keto reductase
IE4872_PD00647	COG0713	ATP synthesis coupled electron transport
IE4872_PD00648	COG0651	ATP synthesis coupled electron transport
IE4872_PD00654	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_PD00655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_PD00656	COG0649	NAD binding
IE4872_PD00660	COG0517	IMP dehydrogenase activity
IE4872_PD00660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IE4872_PD00661	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE4872_PD00662	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IE4872_PD00663	COG1522	sequence-specific DNA binding
IE4872_PD00666	COG1609	Transcriptional regulator
IE4872_PD00667	COG1653	transport
IE4872_PD00670	COG3842	ATPase activity
IE4872_PD00672	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00673	COG0673	inositol 2-dehydrogenase activity
IE4872_PD00674	COG1132	(ABC) transporter
IE4872_PD00675	COG1132	(ABC) transporter
IE4872_PD00679	COG4191	Histidine kinase
IE4872_PD00679	COG0784	Response regulator, receiver
IE4872_PD00680	COG3346	SURF1 family
IE4872_PD00681	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IE4872_PD00682	COG1845	cytochrome c oxidase, subunit III
IE4872_PD00683	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IE4872_PD00684	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IE4872_PD00686	COG0477	Major facilitator Superfamily
IE4872_PD00687	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IE4872_PD00687	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE4872_PD00692	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD00694	COG0747	negative chemotaxis
IE4872_PD00696	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_PD00705	COG1234	tRNA 3'-trailer cleavage
IE4872_PD00706	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00707	COG3153	acetyltransferase
IE4872_PD00708	COG1137	ATPase activity
IE4872_PD00712	COG0683	leucine binding
IE4872_PD00713	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IE4872_PD00715	COG3485	protocatechuate 3,4-dioxygenase
IE4872_PD00716	COG3485	protocatechuate 3,4-dioxygenase
IE4872_PD00717	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE4872_PD00718	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IE4872_PD00719	COG0583	DNA-binding transcription factor activity
IE4872_PD00721	COG1609	Transcriptional regulator
IE4872_PD00722	COG1233	COG1233 Phytoene dehydrogenase and related
IE4872_PD00725	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00726	COG3842	ATPase activity
IE4872_PD00732	COG1917	Cupin 2, conserved barrel domain protein
IE4872_PD00732	COG2169	Transcriptional regulator
IE4872_PD00733	COG4106	trans-aconitate 2-methyltransferase activity
IE4872_PD00736	COG1175	transmembrane transport
IE4872_PD00737	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00743	COG1414	Transcriptional regulator
IE4872_PD00745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IE4872_PD00746	COG0183	Belongs to the thiolase family
IE4872_PD00750	COG0693	protein deglycase activity
IE4872_PD00751	COG4297	protein containing double-stranded beta helix domain
IE4872_PD00752	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE4872_PD00753	COG4774	siderophore transport
IE4872_PD00755	COG2814	Major facilitator Superfamily
IE4872_PD00756	COG4264	IucA IucC family
IE4872_PD00757	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IE4872_PD00758	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IE4872_PD00759	COG0019	diaminopimelate decarboxylase activity
IE4872_PD00760	COG1475	DNA binding
IE4872_PD00761	COG3034	peptidoglycan biosynthetic process
IE4872_PD00762	COG3108	Peptidase M15
IE4872_PD00765	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IE4872_PD00768	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IE4872_PD00769	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_PD00773	COG0784	Response regulator, receiver
IE4872_PD00773	COG4191	Histidine kinase
IE4872_PD00776	COG1573	uracil-dna glycosylase
IE4872_PD00777	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IE4872_PD00780	COG2226	methyltransferase
IE4872_PD00789	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IE4872_PD00790	COG3791	Glutathione-dependent formaldehyde-activating
IE4872_PD00793	COG0477	Major facilitator Superfamily
IE4872_PD00797	COG3842	ATPase activity
IE4872_PD00799	COG1175	transmembrane transport
IE4872_PD00800	COG1653	transport
IE4872_PD00801	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_PD00801	COG2755	lipolytic protein G-D-S-L family
IE4872_PD00802	COG1216	Glycosyl transferase, family 2
IE4872_PD00803	COG1132	(ABC) transporter
IE4872_PD00805	COG0477	Major facilitator Superfamily
IE4872_PD00806	COG1278	Cold shock
IE4872_PD00811	COG1278	Cold shock
IE4872_PD00813	COG3239	Fatty acid desaturase
IE4872_PD00814	COG4251	negative regulation of phosphorylation
IE4872_PD00814	COG5001	Diguanylate cyclase
IE4872_PD00814	COG2203	Gaf domain
IE4872_PD00814	COG3706	GGDEF domain
IE4872_PD00820	COG1295	ribonuclease BN
IE4872_PD00825	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
IE4872_PD00826	COG1695	Transcriptional regulator
IE4872_PD00828	COG0583	DNA-binding transcription factor activity
IE4872_PD00829	COG2814	Major facilitator Superfamily
IE4872_PD00841	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00842	COG3842	ATPase activity
IE4872_PD00843	COG3453	Protein conserved in bacteria
IE4872_PD00843	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_PD00844	COG0450	alkyl hydroperoxide reductase
IE4872_PD00845	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IE4872_PD00846	COG4208	sulfate ABC transporter
IE4872_PD00848	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IE4872_PD00849	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE4872_PD00852	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IE4872_PD00853	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IE4872_PD00855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IE4872_PD00859	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD00860	COG4172	Belongs to the ABC transporter superfamily
IE4872_PD00861	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD00862	COG0601	transmembrane transport
IE4872_PD00863	COG0747	negative chemotaxis
IE4872_PD00865	COG2186	Transcriptional regulator
IE4872_PD00866	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE4872_PD00868	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_PD00869	COG0747	negative chemotaxis
IE4872_PD00870	COG0601	transmembrane transport
IE4872_PD00872	COG0444	Belongs to the ABC transporter superfamily
IE4872_PD00873	COG4608	Belongs to the ABC transporter superfamily
IE4872_PD00875	COG1063	alcohol dehydrogenase
IE4872_PD00879	COG1960	acyl-CoA dehydrogenase activity
IE4872_PD00884	COG0411	ABC transporter
IE4872_PD00885	COG0410	ABC transporter
IE4872_PD00894	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD00896	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PD00898	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD00898	COG3347	Dehydrogenase
IE4872_PD00900	COG4952	isomerase
IE4872_PD00901	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE4872_PD00902	COG1595	DNA-templated transcription, initiation
IE4872_PD00903	COG0747	negative chemotaxis
IE4872_PD00904	COG0601	transmembrane transport
IE4872_PD00906	COG3964	amidohydrolase
IE4872_PD00909	COG1921	L-seryl-tRNASec selenium transferase activity
IE4872_PD00928	COG1175	transmembrane transport
IE4872_PD00929	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00931	COG0352	thiamine-phosphate diphosphorylase activity
IE4872_PD00937	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE4872_PD00937	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IE4872_PD00939	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IE4872_PD00946	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IE4872_PD00947	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IE4872_PD00950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IE4872_PD00951	COG1216	Glycosyl transferase, family 2
IE4872_PD00953	COG2223	nitrite transmembrane transporter activity
IE4872_PD00959	COG2376	Dihydroxyacetone kinase
IE4872_PD00962	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE4872_PD00963	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IE4872_PD00964	COG1461	Dihydroxyacetone kinase
IE4872_PD00966	COG3842	ATPase activity
IE4872_PD00969	COG0395	ABC-type sugar transport system, permease component
IE4872_PD00970	COG1175	transmembrane transport
IE4872_PD00972	COG0842	Transport permease protein
IE4872_PD00973	COG0842	Transport permease protein
IE4872_PD00974	COG1131	(ABC) transporter
IE4872_PD00975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_PD00979	COG1695	Transcriptional regulator
IE4872_PD00983	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PD00988	COG5001	Diguanylate cyclase
IE4872_PD00988	COG2203	Gaf domain
IE4872_PD00988	COG3706	GGDEF domain
IE4872_PD00988	COG4251	negative regulation of phosphorylation
IE4872_PD00993	COG0745	RESPONSE REGULATOR receiver
IE4872_PD00994	COG2205	protein histidine kinase activity
IE4872_PD01000	COG2226	methyltransferase
IE4872_PD01002	COG5001	Diguanylate cyclase
IE4872_PD01004	COG1215	transferase activity, transferring glycosyl groups
IE4872_PD01006	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IE4872_PD01008	COG3706	GGDEF domain
IE4872_PD01009	COG4770	biotin carboxylase activity
IE4872_PD01010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IE4872_PD01011	COG4336	lyase activity
IE4872_PD01012	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IE4872_PD01013	COG1914	H( )-stimulated, divalent metal cation uptake system
IE4872_PD01020	COG2197	response regulator
IE4872_PD01021	COG4585	Histidine kinase
IE4872_PD01023	COG3850	Histidine kinase
IE4872_PD01023	COG5002	protein histidine kinase activity
IE4872_PD01025	COG3706	GGDEF domain
IE4872_PD01025	COG5001	Diguanylate cyclase
IE4872_PD01025	COG2203	Gaf domain
IE4872_PD01025	COG4251	negative regulation of phosphorylation
IE4872_PD01027	COG0850	regulation of cytokinetic process
IE4872_PD01028	COG2894	cell division
IE4872_PD01034	COG2826	transposase and inactivated derivatives, IS30 family
IE4872_PD01041	COG2832	Protein of unknown function (DUF454)
IE4872_PD01045	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IE4872_PD01045	COG2273	Hydrolase Family 16
IE4872_PD01046	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_PD01047	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IE4872_PD01051	COG0483	inositol monophosphate 1-phosphatase activity
IE4872_PD01053	COG3842	ATPase activity
IE4872_PD01061	COG0583	DNA-binding transcription factor activity
IE4872_PD01062	COG0667	Aldo Keto reductase
IE4872_PD01063	COG3842	ATPase activity
IE4872_PD01064	COG0395	ABC-type sugar transport system, permease component
IE4872_PD01065	COG1175	transmembrane transport
IE4872_PD01072	COG1609	Transcriptional regulator
IE4872_PD01073	COG2814	Major facilitator Superfamily
IE4872_PD01075	COG0784	Response regulator, receiver
IE4872_PD01076	COG2373	Large extracellular alpha-helical protein
IE4872_PD01077	COG4953	penicillin-binding protein 1C
IE4872_PD01083	COG0670	Belongs to the BI1 family
IE4872_PD01085	COG2188	Transcriptional regulator
IE4872_PD01087	COG1228	amidohydrolase
IE4872_PD01088	COG2986	histidine ammonia-lyase
IE4872_PD01089	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IE4872_PD01100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_PD01102	COG4988	ABC transporter
IE4872_PD01103	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IE4872_PD01104	COG1271	oxidase subunit
IE4872_PD01105	COG1294	oxidase, subunit
IE4872_PD01108	COG0861	Integral membrane protein TerC family
IE4872_PD01114	COG1120	ATPase activity
IE4872_PD01115	COG4774	siderophore transport
IE4872_PD01116	COG2207	Transcriptional regulator
IE4872_PD01117	COG3618	amidohydrolase
IE4872_PD01118	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE4872_PD01120	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD01121	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01131	COG1129	ABC transporter
IE4872_PD01132	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01133	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01134	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_PD01142	COG1309	transcriptional regulator
IE4872_PD01145	COG3833	ABC-type maltose transport systems, permease component
IE4872_PD01146	COG3842	ATPase activity
IE4872_PD01147	COG0584	glycerophosphoryl diester phosphodiesterase
IE4872_PD01148	COG1609	Transcriptional regulator
IE4872_PD01152	COG0625	glutathione transferase activity
IE4872_PD01155	COG0697	spore germination
IE4872_PD01160	COG0183	Belongs to the thiolase family
IE4872_PD01161	COG1960	acyl-CoA dehydrogenase activity
IE4872_PD01163	COG0022	dehydrogenase e1 component
IE4872_PD01167	COG2022	thiamine diphosphate biosynthetic process
IE4872_PD01170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IE4872_PD01171	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01172	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IE4872_PD01179	COG0395	ABC-type sugar transport system, permease component
IE4872_PD01180	COG3842	ATPase activity
IE4872_PD01182	COG2186	Transcriptional regulator
IE4872_PD01183	COG0747	negative chemotaxis
IE4872_PD01186	COG0405	Gamma-glutamyltransferase
IE4872_PD01188	COG4172	Belongs to the ABC transporter superfamily
IE4872_PD01196	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01200	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IE4872_PD01203	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_PD01204	COG2755	lipolytic protein G-D-S-L family
IE4872_PD01204	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IE4872_PD01206	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IE4872_PD01207	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IE4872_PD01209	COG4310	Domain of unknown function (DUF2172)
IE4872_PD01211	COG2273	Hydrolase Family 16
IE4872_PD01212	COG0438	transferase activity, transferring glycosyl groups
IE4872_PD01213	COG1215	transferase activity, transferring glycosyl groups
IE4872_PD01214	COG3206	protein involved in exopolysaccharide biosynthesis
IE4872_PD01214	COG0489	protein tyrosine kinase activity
IE4872_PD01216	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IE4872_PD01217	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IE4872_PD01218	COG1596	polysaccharide export
IE4872_PD01219	COG3307	-O-antigen
IE4872_PD01221	COG1442	glycosyl transferase family 8
IE4872_PD01222	COG2244	polysaccharide biosynthetic process
IE4872_PD01226	COG0579	oxidoreductase
IE4872_PD01229	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE4872_PD01235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IE4872_PD01236	COG1960	acyl-CoA dehydrogenase activity
IE4872_PD01238	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE4872_PD01241	COG0071	Belongs to the small heat shock protein (HSP20) family
IE4872_PD01242	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IE4872_PD01243	COG0459	protein refolding
IE4872_PD01248	COG4209	transmembrane transport
IE4872_PD01254	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PD01255	COG4172	Belongs to the ABC transporter superfamily
IE4872_PD01264	COG0459	protein refolding
IE4872_PD01265	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_PD01266	COG1999	signal sequence binding
IE4872_PD01270	COG3278	Belongs to the heme-copper respiratory oxidase family
IE4872_PD01275	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE4872_PD01280	COG1138	Cytochrome C-type biogenesis protein
IE4872_PD01281	COG1129	ABC transporter
IE4872_PD01282	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01286	COG0840	transmembrane signaling receptor activity
IE4872_PD01288	COG0583	DNA-binding transcription factor activity
IE4872_PD01289	COG2226	methyltransferase
IE4872_PD01292	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE4872_PD01293	COG1120	ATPase activity
IE4872_PD01296	COG1278	Cold shock
IE4872_PD01309	COG0450	alkyl hydroperoxide reductase
IE4872_PD01311	COG0431	NADPH-dependent FMN reductase
IE4872_PD01312	COG1253	flavin adenine dinucleotide binding
IE4872_PD01313	COG2186	Transcriptional regulator
IE4872_PD01315	COG4608	Belongs to the ABC transporter superfamily
IE4872_PD01316	COG0444	Belongs to the ABC transporter superfamily
IE4872_PD01317	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD01318	COG0601	transmembrane transport
IE4872_PD01319	COG0747	negative chemotaxis
IE4872_PD01320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_PD01322	COG1454	alcohol dehydrogenase
IE4872_PD01323	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IE4872_PD01324	COG0673	inositol 2-dehydrogenase activity
IE4872_PD01325	COG3707	response regulator
IE4872_PD01326	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE4872_PD01327	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE4872_PD01328	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_PD01329	COG1116	anion transmembrane transporter activity
IE4872_PD01330	COG3707	response regulator
IE4872_PD01331	COG1116	anion transmembrane transporter activity
IE4872_PD01331	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE4872_PD01333	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IE4872_PD01335	COG0243	molybdopterin cofactor binding
IE4872_PD01336	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IE4872_PD01336	COG1648	precorrin-2 dehydrogenase activity
IE4872_PD01341	COG0747	negative chemotaxis
IE4872_PD01342	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IE4872_PD01343	COG0601	transmembrane transport
IE4872_PD01344	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD01345	COG0444	Belongs to the ABC transporter superfamily
IE4872_PD01346	COG4608	Belongs to the ABC transporter superfamily
IE4872_PD01349	COG4608	Belongs to the ABC transporter superfamily
IE4872_PD01352	COG0601	transmembrane transport
IE4872_PD01353	COG0747	negative chemotaxis
IE4872_PD01354	COG2186	Transcriptional regulator
IE4872_PD01355	COG1312	Catalyzes the dehydration of D-mannonate
IE4872_PD01356	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_PD01358	COG2084	Dehydrogenase
IE4872_PD01359	COG3622	Belongs to the hyi family
IE4872_PD01361	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD01362	COG0601	transmembrane transport
IE4872_PD01363	COG1874	Beta-galactosidase
IE4872_PD01364	COG0747	negative chemotaxis
IE4872_PD01366	COG1301	dicarboxylic acid transport
IE4872_PD01367	COG4191	Histidine kinase
IE4872_PD01368	COG2204	response regulator
IE4872_PD01371	COG1129	ABC transporter
IE4872_PD01372	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01373	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01374	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IE4872_PD01375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE4872_PD01376	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IE4872_PD01377	COG0156	8-amino-7-oxononanoate synthase activity
IE4872_PD01378	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IE4872_PD01380	COG1132	(ABC) transporter
IE4872_PD01382	COG1120	ATPase activity
IE4872_PD01384	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IE4872_PD01388	COG4214	carbohydrate transport
IE4872_PD01390	COG4213	ABC transporter substrate-binding protein
IE4872_PD01395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE4872_PD01396	COG2963	transposase activity
IE4872_PD01400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IE4872_PD01402	COG0235	Class ii aldolase
IE4872_PD01403	COG3395	kinase activity
IE4872_PD01404	COG2084	Dehydrogenase
IE4872_PD01405	COG3622	Belongs to the hyi family
IE4872_PD01406	COG1609	Transcriptional regulator
IE4872_PD01407	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01408	COG0395	ABC-type sugar transport system, permease component
IE4872_PD01409	COG1175	transmembrane transport
IE4872_PD01411	COG3842	ATPase activity
IE4872_PD01412	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01413	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE4872_PD01414	COG2186	Transcriptional regulator
IE4872_PD01417	COG1881	PFAM PEBP family protein
IE4872_PD01420	COG0434	BtpA family
IE4872_PD01423	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IE4872_PD01424	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01425	COG1129	ABC transporter
IE4872_PD01427	COG1609	Transcriptional regulator
IE4872_PD01429	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IE4872_PD01434	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01435	COG1129	ABC transporter
IE4872_PD01438	COG2186	Transcriptional regulator
IE4872_PD01445	COG2204	response regulator
IE4872_PD01446	COG1215	transferase activity, transferring glycosyl groups
IE4872_PD01447	COG0535	radical SAM domain protein
IE4872_PD01448	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IE4872_PD01449	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IE4872_PD01464	COG4451	ribulose bisphosphate carboxylase, small
IE4872_PD01465	COG1850	ribulose-bisphosphate carboxylase activity
IE4872_PD01467	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IE4872_PD01468	COG3954	Phosphoribulokinase
IE4872_PD01469	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IE4872_PD01470	COG0583	DNA-binding transcription factor activity
IE4872_PD01471	COG2218	PFAM glutamate synthase alpha subunit domain protein
IE4872_PD01472	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
IE4872_PD01473	COG1229	Formylmethanofuran dehydrogenase subunit A
IE4872_PD01475	COG2154	pterin-4-alpha-carbinolamine dehydratase
IE4872_PD01477	COG0702	epimerase
IE4872_PD01479	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
IE4872_PD01480	COG0189	ligase activity
IE4872_PD01482	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
IE4872_PD01483	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IE4872_PD01497	COG1764	response to oxidative stress
IE4872_PD01498	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE4872_PD01501	COG1175	transmembrane transport
IE4872_PD01502	COG1653	transport
IE4872_PD01512	COG0484	heat shock protein binding
IE4872_PD01515	COG1120	ATPase activity
IE4872_PD01516	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE4872_PD01517	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE4872_PD01525	COG0189	ligase activity
IE4872_PD01529	COG4221	oxidoreductase activity
IE4872_PD01530	COG1764	response to oxidative stress
IE4872_PD01534	COG0667	Aldo Keto reductase
IE4872_PD01535	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01539	COG1522	sequence-specific DNA binding
IE4872_PD01543	COG0583	DNA-binding transcription factor activity
IE4872_PD01546	COG4176	ABC-type proline glycine betaine transport system permease component
IE4872_PD01547	COG4176	ABC-type proline glycine betaine transport system permease component
IE4872_PD01548	COG4175	Glycine betaine
IE4872_PD01548	COG3448	diguanylate cyclase activity
IE4872_PD01551	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PD01552	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_PD01553	COG1802	Transcriptional regulator
IE4872_PD01554	COG4638	Rieske (2fe-2S)
IE4872_PD01556	COG0006	proline dipeptidase activity
IE4872_PD01557	COG1396	sequence-specific DNA binding
IE4872_PD01559	COG1846	Transcriptional regulator
IE4872_PD01563	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IE4872_PD01565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IE4872_PD01566	COG2086	electron transfer activity
IE4872_PD01567	COG1902	pentaerythritol trinitrate reductase activity
IE4872_PD01567	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE4872_PD01571	COG4176	ABC-type proline glycine betaine transport system permease component
IE4872_PD01572	COG0517	IMP dehydrogenase activity
IE4872_PD01572	COG4175	Glycine betaine
IE4872_PD01575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IE4872_PD01576	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01577	COG0789	Transcriptional regulator
IE4872_PD01578	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE4872_PD01579	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE4872_PD01582	COG1802	Transcriptional regulator
IE4872_PD01584	COG0318	PFAM AMP-dependent synthetase and ligase
IE4872_PD01590	COG1279	arginine transmembrane transporter activity
IE4872_PD01591	COG0583	DNA-binding transcription factor activity
IE4872_PD01592	COG3077	Addiction module antitoxin, RelB DinJ family
IE4872_PD01597	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IE4872_PD01598	COG1802	Transcriptional regulator
IE4872_PD01599	COG2205	protein histidine kinase activity
IE4872_PD01600	COG0745	RESPONSE REGULATOR receiver
IE4872_PD01614	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IE4872_PD01618	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_PD01624	COG1737	Transcriptional regulator
IE4872_PD01625	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01635	COG3842	ATPase activity
IE4872_PD01637	COG1175	transmembrane transport
IE4872_PD01639	COG1609	Transcriptional regulator
IE4872_PD01642	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IE4872_PD01645	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01646	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE4872_PD01647	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IE4872_PD01652	COG1695	Transcriptional regulator
IE4872_PD01654	COG0583	DNA-binding transcription factor activity
IE4872_PD01655	COG0667	Aldo Keto reductase
IE4872_PD01661	COG0583	DNA-binding transcription factor activity
IE4872_PD01663	COG2226	methyltransferase
IE4872_PD01664	COG0387	Pfam Sodium calcium exchanger
IE4872_PD01673	COG1473	amidohydrolase
IE4872_PD01674	COG3757	hydrolase, family 25
IE4872_PD01683	COG4372	Transposase
IE4872_PD01699	COG1864	DNA RNA non-specific endonuclease
IE4872_PD01699	COG3591	Belongs to the peptidase S1B family
IE4872_PD01704	COG0587	DNA-directed DNA polymerase activity
IE4872_PD01705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE4872_PD01711	COG2002	toxin-antitoxin pair type II binding
IE4872_PD01712	COG0628	permease
IE4872_PD01715	COG0840	transmembrane signaling receptor activity
IE4872_PD01721	COG1566	PFAM secretion protein HlyD family protein
IE4872_PD01724	COG0628	permease
IE4872_PD01734	COG2010	Cytochrome c
IE4872_PD01737	COG3278	Belongs to the heme-copper respiratory oxidase family
IE4872_PD01740	COG0668	transmembrane transport
IE4872_PD01754	COG0723	plastoquinol--plastocyanin reductase activity
IE4872_PD01755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE4872_PD01759	COG0583	DNA-binding transcription factor activity
IE4872_PD01767	COG0251	oxidation-reduction process
IE4872_PD01769	COG0625	glutathione transferase activity
IE4872_PD01773	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01776	COG1846	Transcriptional regulator
IE4872_PD01777	COG3300	MHYT domain
IE4872_PD01777	COG5001	Diguanylate cyclase
IE4872_PD01785	COG1609	Transcriptional regulator
IE4872_PD01793	COG2390	Transcriptional regulator
IE4872_PD01794	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IE4872_PD01795	COG3958	Transketolase
IE4872_PD01796	COG3959	Transketolase, thiamine diphosphate binding domain
IE4872_PD01797	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01798	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PD01799	COG1129	ABC transporter
IE4872_PD01800	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01801	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01802	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE4872_PD01807	COG3920	Histidine kinase
IE4872_PD01807	COG2202	Pas domain
IE4872_PD01813	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IE4872_PD01815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_PD01816	COG1116	anion transmembrane transporter activity
IE4872_PD01818	COG1802	Transcriptional regulator
IE4872_PD01819	COG3842	ATPase activity
IE4872_PD01820	COG1177	transmembrane transport
IE4872_PD01821	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_PD01824	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PD01825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE4872_PD01827	COG2267	carboxylic ester hydrolase activity
IE4872_PD01832	COG0174	glutamine synthetase
IE4872_PD01833	COG0069	glutamate synthase activity
IE4872_PD01834	COG2218	PFAM glutamate synthase alpha subunit domain protein
IE4872_PD01835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IE4872_PD01837	COG4977	sequence-specific DNA binding
IE4872_PD01838	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE4872_PD01839	COG4311	Sarcosine oxidase, delta subunit
IE4872_PD01840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IE4872_PD01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE4872_PD01847	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_PD01850	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01851	COG3842	ATPase activity
IE4872_PD01852	COG1063	alcohol dehydrogenase
IE4872_PD01855	COG1175	transmembrane transport
IE4872_PD01858	COG1082	Xylose isomerase domain protein TIM barrel
IE4872_PD01860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE4872_PD01861	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
IE4872_PD01871	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD01875	COG0784	Response regulator, receiver
IE4872_PD01879	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE4872_PD01881	COG1653	transport
IE4872_PD01891	COG1396	sequence-specific DNA binding
IE4872_PD01893	COG1254	Belongs to the acylphosphatase family
IE4872_PD01896	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IE4872_PD01898	COG0583	DNA-binding transcription factor activity
IE4872_PD01900	COG3246	L-lysine catabolic process to acetate
IE4872_PD01901	COG0824	Thioesterase
IE4872_PD01901	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE4872_PD01902	COG1960	acyl-CoA dehydrogenase activity
IE4872_PD01903	COG0045	succinate-CoA ligase (ADP-forming) activity
IE4872_PD01905	COG0747	negative chemotaxis
IE4872_PD01906	COG0601	transmembrane transport
IE4872_PD01911	COG1522	sequence-specific DNA binding
IE4872_PD01913	COG2186	Transcriptional regulator
IE4872_PD01914	COG1850	ribulose-bisphosphate carboxylase activity
IE4872_PD01917	COG0287	Prephenate dehydrogenase
IE4872_PD01918	COG1879	ABC-type sugar transport system periplasmic component
IE4872_PD01920	COG1129	ABC transporter
IE4872_PD01921	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE4872_PD01922	COG0673	inositol 2-dehydrogenase activity
IE4872_PD01924	COG2376	Dihydroxyacetone kinase
IE4872_PD01925	COG1461	Dihydroxyacetone kinase
IE4872_PD01927	COG0330	HflC and HflK could
IE4872_PD01937	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IE4872_PD01939	COG3842	ATPase activity
IE4872_PD01940	COG1175	transmembrane transport
IE4872_PD01941	COG0395	ABC-type sugar transport system, permease component
IE4872_PD01942	COG1609	Transcriptional regulator
IE4872_PD01943	COG0483	inositol monophosphate 1-phosphatase activity
IE4872_PD01944	COG0584	glycerophosphoryl diester phosphodiesterase
IE4872_PD01945	COG3842	ATPase activity
IE4872_PD01949	COG1940	carbohydrate kinase activity
IE4872_PD01949	COG1846	Transcriptional regulator
IE4872_PD01951	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PD01952	COG0765	amino acid transport
IE4872_PD01953	COG0765	amino acid transport
IE4872_PD01958	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IE4872_PD01959	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE4872_PD01960	COG1126	abc transporter atp-binding protein
IE4872_PD01961	COG0765	amino acid transport
IE4872_PD01962	COG0765	amino acid transport
IE4872_PD01963	COG4221	oxidoreductase activity
IE4872_PD01966	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IE4872_PD01967	COG1984	allophanate hydrolase subunit 2
IE4872_PD01970	COG0439	Biotin carboxylase
IE4872_PD01971	COG0511	ligase activity, forming carbon-carbon bonds
IE4872_PD01977	COG0346	lactoylglutathione lyase activity
IE4872_PD01981	COG4521	taurine ABC transporter
IE4872_PD01982	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IE4872_PD01983	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_PD01987	COG3609	addiction module antidote protein, CC2985 family
IE4872_PD01993	COG0745	RESPONSE REGULATOR receiver
IE4872_PD01994	COG0546	phosphoglycolate phosphatase activity
IE4872_PD01999	COG0596	Alpha beta hydrolase
IE4872_PD02004	COG0318	PFAM AMP-dependent synthetase and ligase
IE4872_PD02006	COG0598	Magnesium transport protein CorA
IE4872_PD02010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IE4872_PD02022	COG0438	transferase activity, transferring glycosyl groups
IE4872_PD02024	COG0728	peptidoglycan biosynthetic process
IE4872_PD02026	COG0438	transferase activity, transferring glycosyl groups
IE4872_PD02031	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE4872_PD02032	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IE4872_PD02032	COG0662	Cupin 2, conserved barrel domain protein
IE4872_PD02033	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IE4872_PD02057	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE4872_PD02058	COG1335	isochorismatase
IE4872_PD02060	COG1335	isochorismatase
IE4872_PD02070	COG0402	S-adenosylhomocysteine deaminase activity
IE4872_PD02071	COG4974	Belongs to the 'phage' integrase family
IE4872_PD02078	COG4944	Protein of unknown function (DUF1109)
IE4872_PD02079	COG1595	DNA-templated transcription, initiation
IE4872_PD02081	COG3220	belongs to the UPF0276 family
IE4872_PD02091	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE4872_PD02094	COG4467	Involved in initiation control of chromosome replication
IE4872_PD02098	COG3436	PFAM IS66 Orf2 family protein
IE4872_PD02100	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD02101	COG3547	Transposase (IS116 IS110 IS902 family)
IE4872_PD02102	COG2207	Transcriptional regulator
IE4872_PD02103	COG4941	Belongs to the sigma-70 factor family
IE4872_PD02107	COG0583	DNA-binding transcription factor activity
IE4872_PD02108	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_PD02108	COG1672	PFAM Archaeal ATPase
IE4872_PD02109	COG4974	Belongs to the 'phage' integrase family
IE4872_PD02110	COG0517	IMP dehydrogenase activity
IE4872_PD02118	COG0517	IMP dehydrogenase activity
IE4872_PD02119	COG1609	Transcriptional regulator
IE4872_PD02121	COG3833	ABC-type maltose transport systems, permease component
IE4872_PD02122	COG1175	transmembrane transport
IE4872_PD02125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE4872_PD02126	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE4872_PD02127	COG1121	(ABC) transporter
IE4872_PD02133	COG3300	MHYT domain
IE4872_PD02133	COG5001	Diguanylate cyclase
IE4872_PD02135	COG3608	succinylglutamate desuccinylase aspartoacylase
IE4872_PD02136	COG0006	proline dipeptidase activity
IE4872_PD02137	COG2423	ornithine cyclodeaminase activity
IE4872_PD02138	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE4872_PD02140	COG0765	amino acid transport
IE4872_PD02141	COG0765	amino acid transport
IE4872_PD02143	COG1126	abc transporter atp-binding protein
IE4872_PD02144	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE4872_PD02145	COG1522	sequence-specific DNA binding
IE4872_PD02146	COG1012	belongs to the aldehyde dehydrogenase family
IE4872_PD02147	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE4872_PD02148	COG1063	alcohol dehydrogenase
IE4872_PD02153	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IE4872_PD02154	COG0720	synthase
IE4872_PD02155	COG0602	queuosine metabolic process
IE4872_PD02161	COG0640	Transcriptional regulator
IE4872_PD02164	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IE4872_PD02171	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE4872_PD02172	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE4872_PD02173	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IE4872_PD02174	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IE4872_PD02175	COG1309	transcriptional regulator
IE4872_PD02189	COG0405	Gamma-glutamyltransferase
IE4872_PD02190	COG4608	Belongs to the ABC transporter superfamily
IE4872_PD02191	COG0444	Belongs to the ABC transporter superfamily
IE4872_PD02193	COG0601	transmembrane transport
IE4872_PD02194	COG0747	negative chemotaxis
IE4872_PD02195	COG1802	Transcriptional regulator
IE4872_PD02198	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IE4872_PD02208	COG0300	oxidoreductase activity
IE4872_PD02210	COG0640	Transcriptional regulator
IE4872_PD02213	COG1476	TRANSCRIPTIONal
IE4872_PD02216	COG0583	DNA-binding transcription factor activity
IE4872_PD02219	COG1028	Short-chain dehydrogenase reductase Sdr
IE4872_PD02220	COG0583	DNA-binding transcription factor activity
IE4872_PD02223	COG0667	Aldo Keto reductase
IE4872_PD02224	COG0583	DNA-binding transcription factor activity
IE4872_PD02225	COG1309	transcriptional regulator
IE4872_PD02226	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD02227	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD02228	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD02230	COG1653	transport
IE4872_PD02233	COG3842	ATPase activity
IE4872_PD02234	COG4948	Mandelate Racemase Muconate Lactonizing
IE4872_PD02236	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IE4872_PD02239	COG3119	arylsulfatase activity
IE4872_PD02248	COG0395	ABC-type sugar transport system, permease component
IE4872_PD02250	COG2182	Extracellular solute-binding protein
IE4872_PD02254	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE4872_PD02256	COG0395	ABC-type sugar transport system, permease component
IE4872_PD02257	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE4872_PD02259	COG3842	ATPase activity
IE4872_PD02274	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IE4872_PD02276	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IE4872_PD02279	COG1596	polysaccharide export
IE4872_PD02284	COG4608	Belongs to the ABC transporter superfamily
IE4872_PD02285	COG0444	Belongs to the ABC transporter superfamily
IE4872_PD02286	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE4872_PD02288	COG0747	negative chemotaxis
IE4872_PD02290	COG0326	Molecular chaperone. Has ATPase activity
IE4872_PD02292	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IE4872_PD02292	COG1672	PFAM Archaeal ATPase
IE4872_PD02293	COG0531	amino acid
IE4872_PD02294	COG1802	Transcriptional regulator
IE4872_PD02305	COG1959	2 iron, 2 sulfur cluster binding
IE4872_PD02306	COG4566	intracellular signal transduction
IE4872_PD02308	COG4191	Histidine kinase
IE4872_PD02310	COG2186	Transcriptional regulator
IE4872_PD02311	COG0673	inositol 2-dehydrogenase activity
IE4872_PD02312	COG0673	inositol 2-dehydrogenase activity
IE4872_PD02314	COG1175	transmembrane transport
IE4872_PD02315	COG0395	ABC-type sugar transport system, permease component
IE4872_PD02316	COG3842	ATPase activity
IE4872_PD02317	COG0697	spore germination
IE4872_PD02318	COG1280	lysine exporter protein (LysE YggA)
IE4872_PD02321	COG4589	Belongs to the CDS family
IE4872_PD02323	COG1253	flavin adenine dinucleotide binding
IE4872_PD02327	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_PD02327	COG2010	Cytochrome c
IE4872_PD02328	COG2080	2 iron, 2 sulfur cluster binding
IE4872_PD02329	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_PD02329	COG2010	Cytochrome c
IE4872_PD02339	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_PD02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE4872_PD02341	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE4872_PD02344	COG2223	nitrite transmembrane transporter activity
IE4872_PD02345	COG1396	sequence-specific DNA binding
IE4872_PD02346	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IE4872_PD02347	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IE4872_PD02348	COG2080	2 iron, 2 sulfur cluster binding
IE4872_PD02349	COG1309	transcriptional regulator
IE4872_PD02356	COG1192	Involved in chromosome partitioning
IE4872_PD02357	COG1475	DNA binding
IE4872_PD02358	COG1414	Transcriptional regulator