locus-tag class description FVA81_00115 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FVA81_00135 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FVA81_00140 ENOG4105C4R Atp-dependent dna helicase FVA81_00155 ENOG4105EHG Permease protein FVA81_00160 ENOG4108W0P ABC transporter FVA81_00180 ENOG4105EKV Phosphonate metabolism protein FVA81_00190 ENOG4105ENV phosphonate C-P lyase system protein PhnK FVA81_00195 ENOG4105HRV phosphonate c-p lyase system protein phnl FVA81_00210 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FVA81_00235 ENOG4108IJF Heavy metal efflux pump, CzcA FVA81_00280 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FVA81_00295 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FVA81_00315 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FVA81_00320 ENOG4105H3G oxidoreductase FVA81_00325 ENOG4105PGM cation diffusion facilitator family transporter FVA81_00345 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FVA81_00360 ENOG4105DA4 cytochrome c-type biogenesis protein FVA81_00370 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FVA81_00400 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FVA81_00410 ENOG4105MSY salicylate hydroxylase FVA81_00435 ENOG41063TF transcriptional regulator (AraC FVA81_00485 ENOG4107R5B glutamine synthetase FVA81_00500 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FVA81_00525 ENOG4105CI0 Citrate lyase FVA81_00530 ENOG4105DJG MaoC domain protein dehydratase FVA81_00540 ENOG4107QX3 carboxylase FVA81_00545 ENOG4105C1G acyl-Coa dehydrogenase FVA81_00550 ENOG4107QN2 dihydrolipoyl dehydrogenase FVA81_00555 ENOG4107QSN dihydrolipoamide acetyltransferase FVA81_00560 ENOG4105CPP Dehydrogenase, E1 component FVA81_00565 ENOG4107R0V Pyruvate dehydrogenase FVA81_00570 ENOG4108K2B transcriptional regulator FVA81_00580 ENOG4105CHU acetyl-coa acetyltransferase FVA81_00585 ENOG4105C1G acyl-Coa dehydrogenase FVA81_00595 ENOG4105C94 Transporter FVA81_00600 ENOG4107QN2 dihydrolipoyl dehydrogenase FVA81_00605 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FVA81_00620 ENOG4105CHJ isochorismatase hydrolase FVA81_00635 ENOG4105CKD glutathione-regulated potassium-efflux system protein FVA81_00645 ENOG4105KVH Transcriptional regulator FVA81_00660 ENOG4105EFZ amidohydrolase FVA81_00665 ENOG4107SFI Major Facilitator superfamily FVA81_00675 ENOG4108YIQ Alpha beta hydrolase FVA81_00680 ENOG4105D6E homoserine dehydrogenase FVA81_00690 ENOG4108UQ8 endoribonuclease L-psp FVA81_00695 ENOG41075H3 AraC family transcriptional regulator FVA81_00700 ENOG41075H3 AraC family transcriptional regulator FVA81_00705 ENOG4105W4W Transcriptional regulator FVA81_00710 ENOG4108JGH Tetr family transcriptional regulator FVA81_00715 ENOG4105CH6 catalase FVA81_00720 ENOG4105FBA Phospholipase Carboxylesterase FVA81_00740 ENOG4105CHJ isochorismatase hydrolase FVA81_00745 ENOG4105EUB pirin domain protein FVA81_00750 ENOG410830R acetyltransferase FVA81_00765 ENOG4105CIS alcohol dehydrogenase FVA81_00775 ENOG4105CPQ Dehydrogenase FVA81_00780 ENOG4105CC0 LysR family Transcriptional regulator FVA81_00790 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FVA81_00835 ENOG4105X54 addiction module antidote protein FVA81_00870 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FVA81_00875 ENOG4108Z7G MaoC domain protein dehydratase FVA81_00885 ENOG4105ETE Transcriptional regulator (LacI family FVA81_00905 ENOG4105E2X shikimate dehydrogenase FVA81_00915 ENOG4105EXW epimerase dehydratase FVA81_00920 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FVA81_00925 ENOG4105ZXK Dehydrogenase FVA81_00930 ENOG4105DIQ Transcriptional regulator FVA81_00935 ENOG4105G63 Type III effector Hrp-dependent FVA81_00945 ENOG4107SET aldo keto reductase FVA81_00955 ENOG4105ETE Transcriptional regulator (LacI family FVA81_00965 ENOG4105D4B ABC, transporter FVA81_00975 ENOG41062B0 ABC transporter, permease FVA81_00980 ENOG4105CMT Dihydroxyacetone kinase FVA81_00990 ENOG4108HMQ sugar kinase FVA81_01015 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_01025 ENOG4105BZU Histidine kinase FVA81_01045 ENOG4105ZXK Dehydrogenase FVA81_01090 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FVA81_01100 ENOG4105CNN ABC, transporter FVA81_01120 ENOG4105K70 DNA-binding protein FVA81_01155 ENOG4105BZU Histidine kinase FVA81_01160 ENOG4108WRK Transcriptional regulator FVA81_01205 ENOG4105CDA abc transporter atp-binding protein FVA81_01210 ENOG4106PMH Extracellular solute-binding protein family 3 FVA81_01215 ENOG4105E5Q amino acid AbC transporter FVA81_01220 ENOG4105E5Q amino acid AbC transporter FVA81_01240 ENOG4105D4B ABC, transporter FVA81_01245 ENOG4105F5R ABC transporter FVA81_01255 ENOG4105C2J ABC transporter FVA81_01260 ENOG4105DKT Transcriptional regulator FVA81_01270 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FVA81_01330 ENOG41067MG lrgb family FVA81_01350 ENOG4105CHR reductase FVA81_01355 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FVA81_01370 ENOG4105C32 Amino acid ABC transporter (Permease) FVA81_01380 ENOG4105C0Z ABC transporter FVA81_01385 ENOG4108IV0 ABC, transporter FVA81_01465 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FVA81_01515 ENOG4105CMR udp-glucose 4-epimerase FVA81_01535 ENOG4105C1B dTDP-glucose 4-6-dehydratase FVA81_01540 ENOG4105C6Y Udp-glucose 6-dehydrogenase FVA81_01560 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FVA81_01585 ENOG4106CD9 glycosyl transferase group 1 FVA81_01595 ENOG4107T8Q Glycosyl transferase (Group 1 FVA81_01615 ENOG4105EQK -acetyltransferase FVA81_01620 ENOG4106WTF Glycosyl transferase, family 2 FVA81_01645 ENOG4107RSM transcriptional regulator FVA81_01660 ENOG4105F38 ABC transporter, permease FVA81_01665 ENOG4108I5D sulfate abc transporter FVA81_01670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_01735 ENOG4105CEY Amp-dependent synthetase and ligase FVA81_01745 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_01755 ENOG41085JF Trap dicarboxylate transporter-dctp subunit FVA81_01760 ENOG4105DRR Transcriptional regulator, GntR family FVA81_01765 ENOG4108IJ9 (ABC) transporter FVA81_01770 ENOG4105CPQ Dehydrogenase FVA81_01780 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FVA81_01825 ENOG4108IPW abc transporter atp-binding protein FVA81_01830 ENOG4105CM4 permease protein FVA81_01835 ENOG4105DHS permease protein FVA81_01855 ENOG4108KPJ rna polymerase sigma factor FVA81_01865 ENOG4105ECY inositol monophosphatase FVA81_01875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_01880 ENOG4105EG2 ABC transporter, permease FVA81_01885 ENOG4105F38 ABC transporter, permease FVA81_01895 ENOG4105ETE Transcriptional regulator (LacI family FVA81_01915 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FVA81_01940 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FVA81_01950 ENOG4105F2Z 3-oxoadipate enol-lactonase FVA81_01960 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FVA81_01965 ENOG410626B catechol 1,2-dioxygenase FVA81_01970 ENOG4105NN7 muconolactone delta-isomerase FVA81_01990 ENOG4105EN6 Membrane FVA81_01995 ENOG4105NXH GreA GreB family elongation factor FVA81_02000 ENOG4105NXH GreA GreB family elongation factor FVA81_02030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FVA81_02035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FVA81_02210 ENOG4107XVH Transcriptional regulator FVA81_02215 ENOG41063TF transcriptional regulator (AraC FVA81_02225 ENOG4107RSM transcriptional regulator FVA81_02265 ENOG4105CSV Glutaminase FVA81_02275 ENOG4105CR8 Transcriptional regulator FVA81_02280 ENOG41080HI glycine oxidase FVA81_02295 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_02305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_02325 ENOG4105CHR reductase FVA81_02340 ENOG4105N14 lysine exporter protein LysE YggA FVA81_02370 ENOG4105DHQ Histidine kinase FVA81_02395 ENOG4105EU0 Major facilitator Superfamily FVA81_02430 ENOG4105EDK PfkB domain protein FVA81_02435 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FVA81_02450 ENOG4105CIB oxidoreductase Domain protein FVA81_02455 ENOG4105ETE Transcriptional regulator (LacI family FVA81_02465 ENOG4105F5R ABC transporter FVA81_02470 ENOG4105C2J ABC transporter FVA81_02505 ENOG4108JDX DNA polymerase iii, epsilon subunit FVA81_02525 ENOG4105E0K tonB-dependent siderophore receptor FVA81_02535 ENOG4105S6R Iron-hydroxamate transporter permease subunit FVA81_02540 ENOG4105E0A ABC, transporter FVA81_02545 ENOG4105BZ1 (ABC) transporter FVA81_02560 ENOG4105DSF transport protein FVA81_02575 ENOG4105EHG Permease protein FVA81_02580 ENOG4108W0P ABC transporter FVA81_02595 ENOG4105DND Transcriptional regulator FVA81_02600 ENOG4105E7W lamb ycsf family protein FVA81_02605 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FVA81_02610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FVA81_02630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_02635 ENOG4105F38 ABC transporter, permease FVA81_02645 ENOG4105CHR reductase FVA81_02660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_02665 ENOG410819M Polysaccharide deacetylase FVA81_02675 ENOG4105CKI cobalamin synthesis protein FVA81_02685 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FVA81_02690 ENOG4105BZU Histidine kinase FVA81_02710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_02815 ENOG4108HQS Glycine betaine FVA81_02820 ENOG4108IJ7 Glycine betaine FVA81_02855 ENOG4105ETT transcriptional Regulator, LysR family FVA81_02860 ENOG4105DVW rieske (2Fe-2S) FVA81_02865 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FVA81_02885 ENOG4108KPW sugar kinase FVA81_02895 ENOG4105FDP GntR family transcriptional regulator FVA81_02900 ENOG4105CDA abc transporter atp-binding protein FVA81_02910 ENOG4105E5Q amino acid AbC transporter FVA81_02915 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FVA81_02960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FVA81_02965 ENOG4105BZU Histidine kinase FVA81_02970 ENOG4105E3E FVA81_02975 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA FVA81_02985 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase FVA81_02990 ENOG4105E8V Alpha Beta Hydrolase Fold protein FVA81_02995 ENOG41077RS Phosphatase FVA81_03010 ENOG4108HPI phosphatidate Cytidylyltransferase FVA81_03040 ENOG4105DIQ Transcriptional regulator FVA81_03045 ENOG4105BZ7 extracellular solute-binding protein family 1 FVA81_03055 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FVA81_03060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_03080 ENOG4105WJ3 XRE family Transcriptional regulator FVA81_03130 ENOG4105BZU Histidine kinase FVA81_03150 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_03165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_03170 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FVA81_03180 ENOG4108JE9 extracellular solute-binding protein family 1 FVA81_03190 ENOG41073TP transcriptional regulator FVA81_03215 ENOG4105C4R Atp-dependent dna helicase FVA81_03235 ENOG4107RSM transcriptional regulator FVA81_03265 ENOG4108IAJ Nad-dependent epimerase dehydratase FVA81_03270 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FVA81_03275 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase FVA81_03280 ENOG4105D2T synthase FVA81_03305 ENOG4105CHR reductase FVA81_03315 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FVA81_03330 ENOG4105EY8 ABC transporter FVA81_03375 ENOG4105D2T synthase FVA81_03380 ENOG4105C2X Arabinose 5-phosphate isomerase FVA81_03390 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase FVA81_03395 ENOG4105F0R Cytidylyltransferase FVA81_03410 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FVA81_03425 ENOG4105C5E polysaccharide biosynthesis protein FVA81_03430 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FVA81_03445 ENOG4105D3Q Sugar transferase FVA81_03450 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FVA81_03475 ENOG4105CXK mandelate racemase muconate lactonizing FVA81_03490 ENOG4105GCH Cupin 2 Conserved Barrel Domain Protein FVA81_03505 ENOG4105EQ2 LysR family Transcriptional regulator FVA81_03520 ENOG4105G9V cytochrome C FVA81_03525 ENOG4107RTG Major Facilitator superfamily FVA81_03530 ENOG4105ENX hydrolase FVA81_03535 ENOG4105EMU Dehydrogenase FVA81_03555 ENOG4105CXK mandelate racemase muconate lactonizing FVA81_03560 ENOG4107YCY Transcriptional regulator FVA81_03570 ENOG4105C2J ABC transporter FVA81_03585 ENOG4105CHR reductase FVA81_03590 ENOG4105BZU Histidine kinase FVA81_03595 ENOG4108ZXC Two component transcriptional regulator, luxr family FVA81_03600 ENOG4108ZXC Two component transcriptional regulator, luxr family FVA81_03605 ENOG4105CHR reductase FVA81_03620 ENOG410642W LysR family Transcriptional regulator FVA81_03625 ENOG4108ZHJ Organic hydroperoxide resistance protein FVA81_03640 ENOG4105CSH Transporter FVA81_03650 ENOG4108ZXC Two component transcriptional regulator, luxr family FVA81_03655 ENOG4105BZU Histidine kinase FVA81_03690 ENOG4105CA0 peroxidase FVA81_03700 ENOG4105KVH Transcriptional regulator FVA81_03725 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FVA81_03730 ENOG4105CKI cobalamin synthesis protein FVA81_03735 ENOG4105NXV High-affinity zinc uptake system protein FVA81_03740 ENOG4105FDK ABC transporter FVA81_03745 ENOG4105FAV ABC, transporter FVA81_03750 ENOG4105MYN Zinc uptake regulation protein FVA81_03755 ENOG4108Z0R Transferase FVA81_03770 ENOG4105DZ1 carboxypeptidase FVA81_03795 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FVA81_03800 ENOG4105D78 K07001 NTE family protein FVA81_03805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FVA81_03810 ENOG4105EUJ GTP cyclohydrolase i FVA81_03820 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FVA81_03830 ENOG4105C22 threonyL-tRNA synthetase FVA81_03845 ENOG41069NU Nitroreductase FVA81_03865 ENOG4105IPI Membrane FVA81_03870 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FVA81_03880 ENOG4105CP7 Triose-phosphate isomerase FVA81_03890 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FVA81_03895 ENOG4105CVM Molybdenum cofactor synthesis domain protein FVA81_03900 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FVA81_03905 ENOG4105DK0 Indole-3-glycerol phosphate synthase FVA81_03910 ENOG4108I0Q anthranilate phosphoribosyltransferase FVA81_03930 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FVA81_03945 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FVA81_03950 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FVA81_03960 ENOG4108JYK Dehydrogenase FVA81_03965 ENOG4105CPP Dehydrogenase, E1 component FVA81_03975 ENOG4105C7S Dehydrogenase FVA81_03990 ENOG4107QN2 dihydrolipoyl dehydrogenase FVA81_04000 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FVA81_04020 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FVA81_04030 ENOG4105CUX Signal transduction histidine kinase FVA81_04035 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_04040 ENOG4105ES5 Histidine kinase FVA81_04045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_04050 ENOG4105C1A potassium transporter peripheral membrane FVA81_04055 ENOG4105F0I Aminotransferase FVA81_04060 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FVA81_04065 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FVA81_04075 ENOG4105DXN mazG family FVA81_04085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FVA81_04105 ENOG4105DP0 ferredoxin-NADP reductase FVA81_04115 ENOG4108IJ7 Glycine betaine FVA81_04130 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FVA81_04200 ENOG4107QIV Cytochrome c biogenesis protein FVA81_04205 ENOG4105RK9 auxin efflux carrier FVA81_04215 ENOG4105VE1 Phosphatidylcholine synthase FVA81_04220 ENOG4105C2J ABC transporter FVA81_04240 ENOG4107EJG GntR family transcriptional regulator FVA81_04245 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FVA81_04250 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FVA81_04260 ENOG4105CB5 ATP-dependent DNA helicase recG FVA81_04275 ENOG4105DFI Membrane FVA81_04285 ENOG4105E43 Extracellular solute-binding protein, family 5 FVA81_04305 ENOG4105C5F glutamine synthetase FVA81_04315 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FVA81_04320 ENOG4105EAM Na Pi-cotransporter FVA81_04330 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FVA81_04335 ENOG4108UUM single-stranded DNA-binding protein FVA81_04340 ENOG4105EXU Membrane FVA81_04345 ENOG41081FY multiple antibiotic resistance (MarC)-related FVA81_04355 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FVA81_04360 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FVA81_04365 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FVA81_04370 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FVA81_04375 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FVA81_04395 ENOG4105E98 transcriptional regulator DeoR family FVA81_04405 ENOG4108IJ7 Glycine betaine FVA81_04410 ENOG4108HQS Glycine betaine FVA81_04430 ENOG4108KN0 Choline kinase FVA81_04440 ENOG4105F8V Hydrolase, tatD family FVA81_04445 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FVA81_04450 ENOG4107QRG dna polymerase iii FVA81_04455 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FVA81_04465 ENOG4105K6T rare lipoprotein A FVA81_04485 ENOG4105WH1 Two component transcriptional regulator luxr family FVA81_04530 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FVA81_04535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_04545 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FVA81_04550 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FVA81_04570 ENOG4105F5V trimethylamine methyltransferase FVA81_04575 ENOG4108Q52 Methyltransferase cognate corrinoid protein FVA81_04655 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FVA81_04695 ENOG4105ECQ AraC Family Transcriptional Regulator FVA81_04710 ENOG4109066 lysm domain bon superfamily protein FVA81_04715 ENOG4105HF0 Membrane FVA81_04725 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_04730 ENOG4105NAU thioesterase Superfamily protein FVA81_04750 ENOG4105BZU Histidine kinase FVA81_04755 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FVA81_04770 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FVA81_04775 ENOG4105VEQ Cold shock protein FVA81_04780 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FVA81_04790 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FVA81_04795 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FVA81_04800 ENOG4105C1G acyl-Coa dehydrogenase FVA81_04805 ENOG4105CD5 CoA-binding domain protein FVA81_04810 ENOG4105E39 Enoyl-CoA hydratase FVA81_04815 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_04820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FVA81_04825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_04830 ENOG4108JQ6 ABC transporter FVA81_04855 ENOG4105EJQ L-serine dehydratase FVA81_04880 ENOG4105CJW magnesium transporter FVA81_04885 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FVA81_04900 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FVA81_04925 ENOG4107QPD alcohol dehydrogenase FVA81_04945 ENOG4108UPT UPF0178 protein FVA81_04955 ENOG4105C4W S-formylglutathione hydrolase FVA81_04960 ENOG4105DSG hydrolase family 43 FVA81_04965 ENOG4105CPC Aldo Keto reductase FVA81_04970 ENOG4107VPB domain protein FVA81_04985 ENOG4108IJ9 (ABC) transporter FVA81_04990 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FVA81_04995 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FVA81_05020 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FVA81_05085 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FVA81_05090 ENOG4108PDG Beta-ketoacyl synthase FVA81_05095 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FVA81_05100 ENOG4105J3Q acyl carrier protein FVA81_05105 ENOG4105D4P Coproporphyrinogen iii oxidase FVA81_05110 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FVA81_05135 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FVA81_05140 ENOG4105QUC reductase FVA81_05150 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FVA81_05155 ENOG4105ED9 Protein of unknown function (DUF455) FVA81_05160 ENOG4105DR5 peptidase FVA81_05165 ENOG4105C1J atp-dependent rna helicase FVA81_05185 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FVA81_05200 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FVA81_05205 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FVA81_05215 ENOG4105CHR reductase FVA81_05220 ENOG4105DJV ribulose-phosphate 3-epimerase FVA81_05235 ENOG4105C83 adenylosuccinate lyase FVA81_05255 ENOG4105BZU Histidine kinase FVA81_05265 ENOG4107QPR SAICAR synthetase FVA81_05270 ENOG410839H phosphoribosylformylglycinamidine synthase FVA81_05280 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FVA81_05295 ENOG41073TP transcriptional regulator FVA81_05300 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FVA81_05325 ENOG4105C2C drug resistance transporter, Bcr CflA FVA81_05330 ENOG4105ECY inositol monophosphatase FVA81_05350 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FVA81_05355 ENOG4105CSV Glutaminase FVA81_05360 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FVA81_05365 ENOG4105DZ1 carboxypeptidase FVA81_05370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FVA81_05380 ENOG4106UW1 Major Facilitator superfamily FVA81_05390 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FVA81_05395 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FVA81_05415 ENOG4105CHH sulfate transporter FVA81_05420 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FVA81_05425 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FVA81_05440 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FVA81_05455 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FVA81_05465 ENOG4105CM6 amino acid regulated cytosolic protein FVA81_05470 ENOG4106K28 UPF0283 membrane protein FVA81_05480 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FVA81_05500 ENOG4107Z7P Ferredoxin FVA81_05525 ENOG4105DHJ ABC, transporter FVA81_05530 ENOG4105CY3 ABC transporter, permease FVA81_05540 ENOG4105C6K Malic enzyme FVA81_05560 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FVA81_05565 ENOG4108MR6 WD40-like Beta Propeller Repeat FVA81_05575 ENOG4105C4K Nad synthetase FVA81_05580 ENOG4107T7U Sulfatase FVA81_05595 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FVA81_05615 ENOG4105E66 phosphoriboisomerase A FVA81_05620 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FVA81_05630 ENOG4105C9Q fumarate hydratase class II FVA81_05640 ENOG4107GFK fumarate FVA81_05645 ENOG4105BZU Histidine kinase FVA81_05660 ENOG4105NTK Transcriptional repressor Mpra FVA81_05670 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FVA81_05675 ENOG4107SDU Methyl-accepting chemotaxis FVA81_05685 ENOG4105CZQ inner membrane transport protein YdhC FVA81_05690 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FVA81_05695 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FVA81_05705 ENOG4106TNF Periplasmic binding protein FVA81_05720 ENOG4105P0T Usg family FVA81_05740 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FVA81_05745 ENOG4108XM1 transcriptional regulator AsnC family FVA81_05750 ENOG4108RG0 uracil-dna glycosylase FVA81_05760 ENOG4105BZU Histidine kinase FVA81_05765 ENOG41085FU Diacylglycerol kinase FVA81_05770 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FVA81_05775 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FVA81_05790 ENOG4105E3A (ABC) transporter FVA81_05795 ENOG4105DA5 (ABC) transporter FVA81_05800 ENOG4105BZU Histidine kinase FVA81_05805 ENOG4108VYJ response regulator receiver protein FVA81_05815 ENOG4105EGS Mechanosensitive ion channel FVA81_05820 ENOG41090JE Utilization Protein FVA81_05830 ENOG4107R4I Periplasmic binding protein FVA81_05835 ENOG4105EHG Permease protein FVA81_05840 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FVA81_05850 ENOG4105JAB phenazine biosynthesis protein, phzf family FVA81_05865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FVA81_05875 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FVA81_05915 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FVA81_05925 ENOG4107TXC Transcriptional regulator FVA81_05935 ENOG4107SID ATP-dependent exodnase (exonuclease v) FVA81_05960 ENOG4105CV8 reductase FVA81_05965 ENOG4105CGD Nad-dependent epimerase dehydratase FVA81_05975 ENOG41082BM Transcriptional regulator, arsr family FVA81_05980 ENOG4108ZP8 Acetolactate synthase small subunit FVA81_05985 ENOG4105C7K acetolactate synthase FVA81_05995 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FVA81_06000 ENOG4105EAC phosphoserine phosphatase FVA81_06005 ENOG4105KNA -acetyltransferase FVA81_06010 ENOG4105BZU Histidine kinase FVA81_06025 ENOG4105EPW hflc protein FVA81_06030 ENOG4107QJR hflk protein FVA81_06040 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FVA81_06070 ENOG4105CQB FAD linked oxidase domain protein FVA81_06075 ENOG4105BZS acriflavin resistance protein FVA81_06090 ENOG4108JMC lipopolysaccharide core biosynthesis protein FVA81_06100 ENOG4107104 thymidine kinase FVA81_06110 ENOG4105DZG Dehydrogenase FVA81_06115 ENOG4108RWI nicotinamidase FVA81_06120 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FVA81_06125 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FVA81_06145 ENOG4105DC7 peptidase M24 FVA81_06150 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FVA81_06170 ENOG4108V3W Chemotaxis protein, CheW FVA81_06185 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FVA81_06190 ENOG4105C1J atp-dependent rna helicase FVA81_06205 ENOG4105BZU Histidine kinase FVA81_06210 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FVA81_06230 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FVA81_06235 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FVA81_06240 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FVA81_06245 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FVA81_06250 ENOG4108UFP Essential cell division protein (By similarity) FVA81_06255 ENOG4105CPF Cell wall formation (By similarity) FVA81_06260 ENOG4105BZU Histidine kinase FVA81_06265 ENOG4105D4A Cell wall formation (By similarity) FVA81_06270 ENOG4105DFU Cell wall formation (By similarity) FVA81_06275 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FVA81_06285 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FVA81_06290 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FVA81_06300 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FVA81_06315 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FVA81_06320 ENOG4108206 Cell division protein mraZ FVA81_06335 ENOG4105E4C Lytic transglycosylase catalytic FVA81_06340 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FVA81_06345 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FVA81_06380 ENOG4107UJ9 cyclopropane-fatty-acyl-phospholipid synthase FVA81_06395 ENOG4105SYT Methylenetetrahydrofolate reductase FVA81_06400 ENOG41085FC arsR family transcriptional regulator FVA81_06420 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FVA81_06425 ENOG4105C7K acetolactate synthase FVA81_06450 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FVA81_06480 ENOG4105C5F glutamine synthetase FVA81_06485 ENOG4105CH5 extracellular solute-binding protein, family 7 FVA81_06490 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_06505 ENOG4106KNT transcriptional regulator FVA81_06520 ENOG4108I5D sulfate abc transporter FVA81_06525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_06545 ENOG4105C3R Methionine synthase FVA81_06550 ENOG4107QKS N-acylglucosamine 2-epimerase FVA81_06555 ENOG4105MPN Membrane FVA81_06565 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FVA81_06570 ENOG4105D85 methylase FVA81_06605 ENOG4108R4U Hnh endonuclease FVA81_06620 ENOG4105D9P serine threonine protein kinase FVA81_06625 ENOG4108ZF3 Phosphatase FVA81_06640 ENOG4107T7U Sulfatase FVA81_06700 ENOG4105ENR peptidase, M24 FVA81_06705 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase FVA81_06735 ENOG4105DUM transcriptional regulator, lysR family FVA81_06740 ENOG4107VFR oxidoreductase FVA81_06755 ENOG4105C26 Dehydrogenase FVA81_06760 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FVA81_06765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_06770 ENOG4105E5Q amino acid AbC transporter FVA81_06795 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FVA81_06800 ENOG4105CH2 amidohydrolase FVA81_06815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_06825 ENOG4105F38 ABC transporter, permease FVA81_06835 ENOG4105ETE Transcriptional regulator (LacI family FVA81_06840 ENOG4105DZC cytosine deaminase FVA81_06855 ENOG4105D7T ABC transporter FVA81_06870 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FVA81_06890 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_06895 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FVA81_06900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_06905 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FVA81_06915 ENOG4108JQ6 ABC transporter FVA81_06925 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FVA81_06945 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FVA81_06960 ENOG4108UMI ABC transporter, permease FVA81_06980 ENOG4105ETX regulatoR FVA81_06985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_06995 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_07000 ENOG4107SCA Formamidase (EC 3.5.1.49) FVA81_07010 ENOG4105C7W Xanthine dehydrogenase FVA81_07015 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FVA81_07020 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FVA81_07060 ENOG41090KN UPF0303 protein FVA81_07080 ENOG4105CH2 amidohydrolase FVA81_07100 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FVA81_07110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FVA81_07120 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FVA81_07125 ENOG4107QI1 Mate efflux family protein FVA81_07135 ENOG4105CGZ zinc metallopeptidase FVA81_07140 ENOG4108RXX maleylacetoacetate isomerase FVA81_07145 ENOG4105CPQ Dehydrogenase FVA81_07155 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_07170 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FVA81_07200 ENOG4105C57 major facilitator superfamily FVA81_07205 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FVA81_07215 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FVA81_07230 ENOG4105F7P transcriptional regulator AsnC family FVA81_07235 ENOG4105C3M thioredoxin reductase FVA81_07240 ENOG4105EJC lysr family transcriptional regulator FVA81_07250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FVA81_07285 ENOG4105D8V Glucose sorbosone dehydrogenase FVA81_07290 ENOG4105CHM Aminotransferase FVA81_07300 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase FVA81_07320 ENOG4105C5X domain protein FVA81_07325 ENOG41090HR transcriptional regulator FVA81_07330 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FVA81_07335 ENOG4105E0F Histidine kinase FVA81_07340 ENOG4108Z7R Chaperone CsaA FVA81_07345 ENOG4105II7 pyrroline-5-carboxylate reductase FVA81_07360 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FVA81_07370 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FVA81_07385 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FVA81_07400 ENOG4105C26 Dehydrogenase FVA81_07410 ENOG4105BZU Histidine kinase FVA81_07415 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FVA81_07420 ENOG4105BZU Histidine kinase FVA81_07430 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FVA81_07435 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FVA81_07440 ENOG41062ES Transcriptional regulator FVA81_07445 ENOG4105D74 hydrolase FVA81_07455 ENOG4108UQ8 endoribonuclease L-psp FVA81_07460 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FVA81_07465 ENOG4105C3G gtp-binding protein FVA81_07505 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FVA81_07510 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FVA81_07520 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FVA81_07525 ENOG4105BZ1 (ABC) transporter FVA81_07550 ENOG4105BZ1 (ABC) transporter FVA81_07555 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FVA81_07575 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FVA81_07590 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FVA81_07595 ENOG4105P8F nudix hydrolase FVA81_07605 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FVA81_07630 ENOG4105VEV -acetyltransferase FVA81_07640 ENOG4105CY0 Metallo-Beta-Lactamase FVA81_07650 ENOG4105CHF Glutathione S-transferase FVA81_07655 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FVA81_07670 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FVA81_07680 ENOG4105DKK Benzoate FVA81_07685 ENOG4106TD9 Diguanylate cyclase FVA81_07690 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) FVA81_07705 ENOG4107RSM transcriptional regulator FVA81_07715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_07825 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_07840 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of FVA81_07845 ENOG4107UEK pfkb domain protein FVA81_07855 ENOG4105CHR reductase FVA81_07860 ENOG4105CPQ Dehydrogenase FVA81_07865 ENOG4105ETE Transcriptional regulator (LacI family FVA81_07870 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FVA81_07880 ENOG4106P19 photosystem i assembly btpa FVA81_07885 ENOG4105D7K pfkb domain protein FVA81_07895 ENOG41080QX K07048 phosphotriesterase-related protein FVA81_07900 ENOG4105CNN ABC, transporter FVA81_07905 ENOG4105C2J ABC transporter FVA81_07910 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FVA81_07915 ENOG4105ETE Transcriptional regulator (LacI family FVA81_07940 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FVA81_07945 ENOG4108ESY Metal dependent phosphohydrolase FVA81_07965 ENOG4105BZU Histidine kinase FVA81_07970 ENOG4107RGH Aldehyde dehydrogenase FVA81_08010 ENOG4105BZ1 (ABC) transporter FVA81_08025 ENOG4105CNG UPF0061 protein FVA81_08040 ENOG4105EAB amino acid AbC transporter FVA81_08045 ENOG4105E5Q amino acid AbC transporter FVA81_08050 ENOG4105CDA abc transporter atp-binding protein FVA81_08060 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FVA81_08075 ENOG4105VDM plasmid maintenance system antidote protein, xre family FVA81_08080 ENOG4105CRQ synthase (Component I) FVA81_08090 ENOG4107ENK receptor FVA81_08095 ENOG4105CKU formyltetrahydrofolate synthetase FVA81_08105 ENOG4105CHR reductase FVA81_08110 ENOG4105CF7 AraC family transcriptional regulator FVA81_08115 ENOG4105C26 Dehydrogenase FVA81_08120 ENOG4105EW9 transcriptional regulator AsnC family FVA81_08125 ENOG4105VJY transcriptional regulator FVA81_08175 ENOG4108IJ7 Glycine betaine FVA81_08185 ENOG41080HT Transcriptional regulator, arsr family FVA81_08190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FVA81_08230 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FVA81_08235 ENOG4105CPN adenine deaminase FVA81_08255 ENOG4105CG3 alpha amylase, catalytic region FVA81_08265 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FVA81_08300 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FVA81_08305 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FVA81_08320 ENOG4105C7W Xanthine dehydrogenase FVA81_08335 ENOG4105ETT transcriptional Regulator, LysR family FVA81_08345 ENOG4107QUY Guanine deaminase FVA81_08360 ENOG4105DMF Dehydrogenase FVA81_08375 ENOG4108Z2U ureidoglycolate hydrolase FVA81_08390 ENOG4107R5B glutamine synthetase FVA81_08400 ENOG4105DHG Allantoate amidinohydrolase FVA81_08405 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) FVA81_08410 ENOG4105DQ4 alcohol dehydrogenase FVA81_08430 ENOG4108TXN phosphonate metabolism protein FVA81_08435 ENOG41087SS fad dependent oxidoreductase FVA81_08440 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FVA81_08445 ENOG4105BZU Histidine kinase FVA81_08450 ENOG4105F5V trimethylamine methyltransferase FVA81_08465 ENOG4105F1N DNA alkylation repair FVA81_08475 ENOG4105C1J atp-dependent rna helicase FVA81_08540 ENOG4105CMR udp-glucose 4-epimerase FVA81_08550 ENOG4105C5H ABC transporter FVA81_08555 ENOG4108Z18 K06886 hemoglobin FVA81_08580 ENOG4105BZ8 glutamate synthase FVA81_08585 ENOG4107SJI Dehydrogenase FVA81_08590 ENOG4105BZU Histidine kinase FVA81_08595 ENOG4108TPP exopolysaccharide synthesis FVA81_08605 ENOG4108R86 Transcriptional regulator FVA81_08610 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FVA81_08620 ENOG4105CD3 dihydroorotase FVA81_08645 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FVA81_08650 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FVA81_08655 ENOG4105D2X ABC transporter substrate-binding protein FVA81_08675 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FVA81_08680 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FVA81_08685 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) FVA81_08690 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria FVA81_08700 ENOG4105CQM Urea amidohydrolase subunit alpha FVA81_08705 ENOG4106ISJ urease accessory protein FVA81_08710 ENOG4105VTN Protein of unknown function (DUF1311) FVA81_08715 ENOG4105KI2 Urea amidohydrolase subunit beta FVA81_08720 ENOG4105XDF Protein of unknown function (DUF1272) FVA81_08725 ENOG4108YZ9 Urea amidohydrolase subunit gamma FVA81_08730 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FVA81_08740 ENOG4108IV0 ABC, transporter FVA81_08745 ENOG4105C0Z ABC transporter FVA81_08755 ENOG4105C32 Amino acid ABC transporter (Permease) FVA81_08770 ENOG4105BZU Histidine kinase FVA81_08780 ENOG4105BZU Histidine kinase FVA81_08785 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FVA81_08795 ENOG4105CP9 extracellular ligand-binding receptor FVA81_08805 ENOG4108IV0 ABC, transporter FVA81_08810 ENOG4105C0Z ABC transporter FVA81_08815 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FVA81_08820 ENOG4105C32 Amino acid ABC transporter (Permease) FVA81_08830 ENOG4107SDU Methyl-accepting chemotaxis FVA81_08845 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FVA81_08850 ENOG4105WIU sarcosine oxidase delta subunit FVA81_08855 ENOG4105DDR sarcosine oxidase (Beta subunit) FVA81_08860 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FVA81_08870 ENOG4105VJY transcriptional regulator FVA81_08895 ENOG4105EFQ Two component transcriptional regulator (Winged helix family FVA81_08920 ENOG4105FCS tRNA rRNA methyltransferase FVA81_08940 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FVA81_08950 ENOG4105CJ1 ABC, transporter FVA81_08960 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FVA81_08965 ENOG4108IPJ Membrane FVA81_08970 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FVA81_08995 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FVA81_09005 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN FVA81_09045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_09050 ENOG4105DG4 malate L-lactate dehydrogenase FVA81_09065 ENOG4107S8C mandelate racemase muconate lactonizing FVA81_09070 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FVA81_09090 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FVA81_09105 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FVA81_09110 ENOG4105C4M (Ubiquinol oxidase) subunit I FVA81_09115 ENOG4108JQ1 Dehydrogenase FVA81_09140 ENOG4105DEN Luciferase family FVA81_09145 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FVA81_09160 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FVA81_09175 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FVA81_09180 ENOG4105M6F mutator MutT protein FVA81_09195 ENOG4107YD3 Thioesterase FVA81_09200 ENOG4105E02 MotA TolQ exbB proton channel FVA81_09205 ENOG4105M8F Biopolymer transport protein exbD tolR FVA81_09215 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FVA81_09220 ENOG4105KCK Peptidoglycan-associated lipoprotein FVA81_09230 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FVA81_09235 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FVA81_09240 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FVA81_09245 ENOG4105CDY transcriptional regulatory protein FVA81_09260 ENOG4105D48 metallophosphoesterase FVA81_09265 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FVA81_09300 ENOG4105C94 Transporter FVA81_09305 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FVA81_09310 ENOG4105BZA Phosphoglycerate kinase FVA81_09320 ENOG4105JAB phenazine biosynthesis protein, phzf family FVA81_09350 ENOG41082FS 50S ribosomal protein L31 FVA81_09355 ENOG4105BZ1 (ABC) transporter FVA81_09365 ENOG4105UYK outer membrane protein a FVA81_09375 ENOG4105ECY inositol monophosphatase FVA81_09380 ENOG4107PU6 Membrane FVA81_09400 ENOG4105MHT Transcriptional regulator, ARSR family FVA81_09415 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FVA81_09420 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FVA81_09425 ENOG4105YK5 50S ribosomal protein L36 FVA81_09430 ENOG4105M0T TPR Repeat-Containing Protein FVA81_09440 ENOG4105CA9 Pyruvate kinase FVA81_09460 ENOG4105Y2X UPF0335 protein FVA81_09470 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_09495 ENOG4105EMU Dehydrogenase FVA81_09500 ENOG410642W LysR family Transcriptional regulator FVA81_09510 ENOG4105FE5 Homospermidine synthase FVA81_09515 ENOG4105ZWB Outer membrane lipoprotein FVA81_09520 ENOG4105CGH 5'-nucleotidase FVA81_09525 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FVA81_09535 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_09540 ENOG4107QX8 SPFH domain, Band 7 family protein FVA81_09550 ENOG4105C2X Arabinose 5-phosphate isomerase FVA81_09565 ENOG4105CVE Lytic murein transglycosylase FVA81_09610 ENOG4108ZNX Heat shock protein FVA81_09660 ENOG4105NPQ Pfam:DUF403 FVA81_09675 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FVA81_09680 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FVA81_09685 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FVA81_09690 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FVA81_09695 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FVA81_09710 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FVA81_09720 ENOG4105CAU Arsenical resistance protein, ArsH FVA81_09755 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FVA81_09765 ENOG4105DDR sarcosine oxidase (Beta subunit) FVA81_09770 ENOG4105K5G 30S ribosomal protein S21 FVA81_09790 ENOG4105BZU Histidine kinase FVA81_09800 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_09805 ENOG4105CH5 extracellular solute-binding protein, family 7 FVA81_09815 ENOG4105C5I Dehydrogenase FVA81_09820 ENOG4105ETE Transcriptional regulator (LacI family FVA81_09825 ENOG4107MII Sugar-specific transcriptional regulator TrmB FVA81_09835 ENOG4105CKI cobalamin synthesis protein FVA81_09865 ENOG4105HEI LysR family (Transcriptional regulator FVA81_09895 ENOG4108UHU Aldolase FVA81_09900 ENOG41080ZE Adenylate cyclase FVA81_09910 ENOG4105C72 UPF0176 protein FVA81_09925 ENOG4108RCM Nitroreductase FVA81_09930 ENOG4105KVH Transcriptional regulator FVA81_09945 ENOG4105EQK -acetyltransferase FVA81_09955 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FVA81_09960 ENOG4105CNN ABC, transporter FVA81_09965 ENOG4105C2J ABC transporter FVA81_09970 ENOG4105ETE Transcriptional regulator (LacI family FVA81_09980 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FVA81_09985 ENOG4105C93 Xylose Isomerase FVA81_09990 ENOG4105CMG Carbohydrate kinase FVA81_09995 ENOG4105ETE Transcriptional regulator (LacI family FVA81_10010 ENOG4105J7D transcriptional regulator FVA81_10015 ENOG4105EE5 Membrane protein terC FVA81_10025 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FVA81_10030 ENOG4105CRK lysyL-tRNA synthetase FVA81_10050 ENOG4105DIK (ABC) transporter FVA81_10055 ENOG4105CC5 ABC transporter FVA81_10060 ENOG4105CC5 ABC transporter FVA81_10070 ENOG4105DFI Membrane FVA81_10075 ENOG4107RSM transcriptional regulator FVA81_10080 ENOG4107TYH extracellular solute-binding protein family 1 FVA81_10085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_10090 ENOG4105D81 ABC transporter, permease FVA81_10095 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FVA81_10120 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FVA81_10125 ENOG4105DKT Transcriptional regulator FVA81_10140 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FVA81_10170 ENOG4108JQ6 ABC transporter FVA81_10175 ENOG4105CH2 amidohydrolase FVA81_10190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_10195 ENOG410841Q phosphoesterase PA-phosphatase related protein FVA81_10215 ENOG4108IGT Dipeptidase FVA81_10220 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FVA81_10225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_10230 ENOG4105F38 ABC transporter, permease FVA81_10235 ENOG4105D38 putrescine abc transporter FVA81_10240 ENOG4108HM4 ABC transporter FVA81_10250 ENOG4105CPN adenine deaminase FVA81_10275 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FVA81_10290 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FVA81_10295 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FVA81_10350 ENOG41074H6 response regulator FVA81_10395 ENOG4105C5I Dehydrogenase FVA81_10400 ENOG4105E39 Enoyl-CoA hydratase FVA81_10415 ENOG4105MHT Transcriptional regulator, ARSR family FVA81_10420 ENOG4105CFF transcriptional regulator FVA81_10425 ENOG4107QX3 carboxylase FVA81_10430 ENOG4105CYM Glutathione S-transferase FVA81_10460 ENOG4105F38 ABC transporter, permease FVA81_10465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_10475 ENOG4105CYW agmatinase FVA81_10480 ENOG4105ETT transcriptional Regulator, LysR family FVA81_10485 ENOG4105CHM Aminotransferase FVA81_10490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FVA81_10500 ENOG4105DH8 myo-inositol catabolism FVA81_10515 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FVA81_10520 ENOG4105D7K pfkb domain protein FVA81_10535 ENOG4107TYG Oxidoreductase domain-containing protein FVA81_10545 ENOG4105FKQ transcriptional regulator FVA81_10580 ENOG4105ETX regulatoR FVA81_10605 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_10610 ENOG4105CQZ Histidine kinase FVA81_10625 ENOG4105EVH UPF0753 protein FVA81_10630 ENOG4105D65 subunit l FVA81_10635 ENOG4105DUM transcriptional regulator, lysR family FVA81_10650 ENOG4108WQI RNA Polymerase FVA81_10660 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FVA81_10665 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FVA81_10670 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FVA81_10675 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FVA81_10680 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FVA81_10685 ENOG4105DDW LysR family Transcriptional regulator FVA81_10690 ENOG4107HP6 Transcriptional regulator FVA81_10700 ENOG4107QNJ CoA-transferase subunit B FVA81_10705 ENOG4105CHU acetyl-coa acetyltransferase FVA81_10715 ENOG4105BZU Histidine kinase FVA81_10720 ENOG4106N3A copper homeostasis protein cutc FVA81_10735 ENOG4105E2D ec 3.2.1.52 FVA81_10740 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FVA81_10745 ENOG4106KNT transcriptional regulator FVA81_10775 ENOG4108IJ9 (ABC) transporter FVA81_10785 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FVA81_10790 ENOG4105D56 permease protein FVA81_10800 ENOG4105FDP GntR family transcriptional regulator FVA81_10805 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FVA81_10810 ENOG4105CE4 GlcNAc 6-P deacetylase FVA81_10815 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FVA81_10830 ENOG410633P Hydantoin racemase FVA81_10835 ENOG4105EG2 ABC transporter, permease FVA81_10840 ENOG4105F38 ABC transporter, permease FVA81_10850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_10860 ENOG4107EJG GntR family transcriptional regulator FVA81_10865 ENOG41062B0 ABC transporter, permease FVA81_10870 ENOG4107R9N ABC transporter FVA81_10875 ENOG4105C2J ABC transporter FVA81_10880 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FVA81_10890 ENOG4105WH1 Two component transcriptional regulator luxr family FVA81_10895 ENOG4105C6Y Udp-glucose 6-dehydrogenase FVA81_10900 ENOG4105KZJ alginate biosynthesis protein Alg8 FVA81_10905 ENOG4108UIA Alginate biosynthesis protein Alg44 FVA81_10910 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FVA81_10920 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FVA81_10925 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate FVA81_10960 ENOG4108V3W Chemotaxis protein, CheW FVA81_10975 ENOG41080HT Transcriptional regulator, arsr family FVA81_10990 ENOG4105BZS acriflavin resistance protein FVA81_11000 ENOG4107SV1 subunit D FVA81_11005 ENOG41082A2 Alpha beta hydrolase FVA81_11010 ENOG4105EWK phytoene FVA81_11015 ENOG4105FE1 phytoene synthase FVA81_11030 ENOG4105CTB Polyprenyl synthetase FVA81_11040 ENOG4107XHQ chlorophyll synthesis pathway, bchC FVA81_11045 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) FVA81_11050 ENOG41060GA Chlorophyllide reductase subunit Y FVA81_11070 ENOG41068GY Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity) FVA81_11090 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FVA81_11095 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FVA81_11105 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) FVA81_11130 ENOG4105XCI PucC protein FVA81_11135 ENOG4108MIC Mg-protoporphyrin IX methyl transferase FVA81_11140 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) FVA81_11145 ENOG4105CTK cobaltochelatase, cobn subunit FVA81_11150 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) FVA81_11155 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) FVA81_11160 ENOG4108VJI 2-vinyl bacteriochlorophyllide hydratase FVA81_11170 ENOG4105D4D transcriptional regulator FVA81_11175 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase FVA81_11180 ENOG4105SS7 PucC protein FVA81_11185 ENOG4107QZT geranylgeranyl reductase FVA81_11190 ENOG4105KAV tspo and mbr like protein FVA81_11200 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FVA81_11210 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FVA81_11220 ENOG4105FDP GntR family transcriptional regulator FVA81_11230 ENOG4107QM2 Aldo Keto reductase FVA81_11245 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_11250 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FVA81_11265 ENOG4105EYU Glutamine amido-transferase FVA81_11270 ENOG4105M90 Glutamate synthase alpha subunit domain protein FVA81_11275 ENOG4105CBC glutamate synthase FVA81_11295 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FVA81_11300 ENOG4105BZ7 extracellular solute-binding protein family 1 FVA81_11315 ENOG4105FKQ transcriptional regulator FVA81_11335 ENOG4105CNN ABC, transporter FVA81_11340 ENOG4105C2J ABC transporter FVA81_11345 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FVA81_11360 ENOG4105C2J ABC transporter FVA81_11365 ENOG4105CNN ABC, transporter FVA81_11370 ENOG4105ETE Transcriptional regulator (LacI family FVA81_11375 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_11380 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_11390 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FVA81_11400 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FVA81_11405 ENOG4107S9B Shikimate dehydrogenase FVA81_11410 ENOG4108W9H Tetr family transcriptional regulator FVA81_11415 ENOG4105C9F isomerase FVA81_11435 ENOG4105C2J ABC transporter FVA81_11440 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FVA81_11445 ENOG4105F5R ABC transporter FVA81_11450 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FVA81_11465 ENOG4105E0K tonB-dependent siderophore receptor FVA81_11470 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FVA81_11475 ENOG4105DQ5 transport system permease protein FVA81_11480 ENOG4105TVJ transport system, permease FVA81_11485 ENOG4105E0A ABC, transporter FVA81_11500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_11505 ENOG4107RCV ABC transporter, permease FVA81_11510 ENOG4105C4Y ABC transporter FVA81_11515 ENOG4105C4Y ABC transporter FVA81_11520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FVA81_11535 ENOG4105BZU Histidine kinase FVA81_11550 ENOG4105CNN ABC, transporter FVA81_11560 ENOG4105DIQ Transcriptional regulator FVA81_11570 ENOG4105CPQ Dehydrogenase FVA81_11575 ENOG4105C5I Dehydrogenase FVA81_11580 ENOG4105CHR reductase FVA81_11585 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FVA81_11590 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FVA81_11600 ENOG4105DIQ Transcriptional regulator FVA81_11605 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FVA81_11610 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_11615 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FVA81_11620 ENOG4105DIQ Transcriptional regulator FVA81_11625 ENOG4105YA8 Transcriptional regulator FVA81_11640 ENOG4105NFY transcriptional modulator of maze toxin, mazf FVA81_11645 ENOG4106FC9 Protein of unknown function (DUF3018) FVA81_11675 ENOG4105E5H Transposase FVA81_11745 ENOG4105C8V SAICAR synthetase FVA81_11760 ENOG4105BZS acriflavin resistance protein FVA81_11770 ENOG4105W1Y Transcriptional regulator FVA81_11775 ENOG4108JPW Aminotransferase FVA81_11780 ENOG4105C26 Dehydrogenase FVA81_11785 ENOG4105C5Q Transcriptional regulator FVA81_11795 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FVA81_11800 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FVA81_11810 ENOG410609C Acyl carrier protein FVA81_11855 ENOG4108JPW Aminotransferase FVA81_11865 ENOG4105ETT transcriptional Regulator, LysR family FVA81_11870 ENOG4105CJP fad dependent oxidoreductase FVA81_11875 ENOG4105C26 Dehydrogenase FVA81_11890 ENOG4108ZZF transport protein (ExbD) FVA81_11905 ENOG4108R6K riboflavin synthase, subunit alpha FVA81_11925 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FVA81_11945 ENOG4105C1G acyl-Coa dehydrogenase FVA81_11950 ENOG4108MGI Transcriptional regulator FVA81_11955 ENOG4105DN3 alpha-2-macroglobulin domain protein FVA81_11960 ENOG4108JQB penicillin-binding protein 1C FVA81_12010 ENOG4105HFZ Membrane FVA81_12045 ENOG4105WH1 Two component transcriptional regulator luxr family FVA81_12050 ENOG4105DJP Membrane FVA81_12055 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FVA81_12060 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_12065 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FVA81_12080 ENOG4105CQB FAD linked oxidase domain protein FVA81_12085 ENOG4105EXW epimerase dehydratase FVA81_12090 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FVA81_12095 ENOG4105C01 Dihydroxy-acid dehydratase FVA81_12105 ENOG41074H6 response regulator FVA81_12135 ENOG4108IRC dna polymerase iii FVA81_12145 ENOG4105W87 Cbs domain FVA81_12150 ENOG4107QN1 sodium solute FVA81_12160 ENOG4107QZ7 Cellulose synthase catalytic subunit FVA81_12195 ENOG4105RQF LysR family Transcriptional regulator FVA81_12205 ENOG4105D7T ABC transporter FVA81_12210 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component FVA81_12215 ENOG4107TTD cytosine deaminase FVA81_12225 ENOG4105DYS nad(p)h dehydrogenase (quinone) FVA81_12230 ENOG4105KME endoribonuclease L-psp FVA81_12265 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_12270 ENOG4108JQ6 ABC transporter FVA81_12275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_12280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FVA81_12285 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_12305 ENOG4105C0A alcohol dehydrogenase FVA81_12310 ENOG41073TP transcriptional regulator FVA81_12315 ENOG4107S2N Type III effector Hrp-dependent FVA81_12325 ENOG4108VGW abc transporter atp-binding protein FVA81_12330 ENOG4105CXZ ABC transporter, permease FVA81_12335 ENOG4105VNH ABC transporter solute-binding protein FVA81_12355 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FVA81_12365 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FVA81_12370 ENOG41064T2 transcriptional regulator, lysR family FVA81_12390 ENOG4105C0Z ABC transporter FVA81_12395 ENOG4108IV0 ABC, transporter FVA81_12400 ENOG4105C32 Amino acid ABC transporter (Permease) FVA81_12405 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FVA81_12435 ENOG4107F9Y LysR family transcriptional regulator FVA81_12450 ENOG4107T8Q Glycosyl transferase (Group 1 FVA81_12455 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FVA81_12485 ENOG4105D3Q Sugar transferase FVA81_12510 ENOG4105WH1 Two component transcriptional regulator luxr family FVA81_12550 ENOG4108JQ7 (ABC) transporter FVA81_12560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FVA81_12565 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_12570 ENOG4105DER m42 family FVA81_12575 ENOG4105CC0 LysR family Transcriptional regulator FVA81_12585 ENOG4105C1P efflux transporter, rnd family, mfp subunit FVA81_12605 ENOG4108IJ9 (ABC) transporter FVA81_12625 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FVA81_12635 ENOG4105ETE Transcriptional regulator (LacI family FVA81_12660 ENOG4108JJ6 Type I secretion system ATPase FVA81_12670 ENOG4107YCY Transcriptional regulator FVA81_12675 ENOG4108ERU trap dicarboxylate transporter subunit DctP FVA81_12685 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_12690 ENOG4105CPQ Dehydrogenase FVA81_12695 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FVA81_12700 ENOG4105DEI Mannitol dehydrogenase FVA81_12705 ENOG4108WYP Transcriptional regulator FVA81_12715 ENOG4105CD3 dihydroorotase FVA81_12735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_12740 ENOG4105C3U ABC transporter FVA81_12755 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FVA81_12765 ENOG4105CHR reductase FVA81_12770 ENOG41073TP transcriptional regulator FVA81_12780 ENOG4105E5Q amino acid AbC transporter FVA81_12785 ENOG4105CDA abc transporter atp-binding protein FVA81_12790 ENOG4105C9B Cysteine desulfurase FVA81_12810 ENOG4105C32 Amino acid ABC transporter (Permease) FVA81_12815 ENOG4108IV0 ABC, transporter FVA81_12820 ENOG4105C0Z ABC transporter FVA81_12825 ENOG4108WYP Transcriptional regulator FVA81_12840 ENOG4105CP9 extracellular ligand-binding receptor FVA81_12890 ENOG4105E4C Lytic transglycosylase catalytic FVA81_12895 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FVA81_12905 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FVA81_12910 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FVA81_12915 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FVA81_12920 ENOG4105CFH Aspartokinase FVA81_12925 ENOG4105FF5 Membrane FVA81_12940 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FVA81_12965 ENOG4105VW4 glutaredoxin 3 FVA81_12970 ENOG41081UC Inherit from COG: Competence protein FVA81_12975 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FVA81_12990 ENOG4105M6F mutator MutT protein FVA81_12995 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FVA81_13000 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FVA81_13005 ENOG4105EIN peptidylprolyl cis-trans isomerase FVA81_13010 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FVA81_13040 ENOG4108UM1 dedA family FVA81_13060 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FVA81_13070 ENOG4105E1F short-chain dehydrogenase reductase FVA81_13090 ENOG4105BZJ Electron transfer flavoprotein FVA81_13095 ENOG4105C10 Electron transfer flavoprotein FVA81_13100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FVA81_13105 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FVA81_13110 ENOG4108I5D sulfate abc transporter FVA81_13115 ENOG4105ECW sulfate abc transporter FVA81_13120 ENOG4108IJ6 ABC transporter FVA81_13125 ENOG4105BZU Histidine kinase FVA81_13130 ENOG4107ZT5 Thiol disulfide interchange protein FVA81_13135 ENOG4105CH7 arginosuccinase FVA81_13145 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FVA81_13160 ENOG4108UGV hypoxanthine phosphoribosyltransferase FVA81_13170 ENOG4105CAK Cell division ATP-binding protein ftsE FVA81_13190 ENOG4108NH8 Cation transport protein FVA81_13205 ENOG4105CIH Imidazole acetol-phosphate transaminase FVA81_13210 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FVA81_13215 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FVA81_13240 ENOG4105KDC 50s ribosomal protein l28 FVA81_13245 ENOG4105EX9 Membrane FVA81_13275 ENOG4108JU6 CBS domain protein FVA81_13280 ENOG4105D49 3-dehydroquinate synthase FVA81_13285 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FVA81_13290 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FVA81_13295 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FVA81_13300 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FVA81_13305 ENOG4105VFE sira family FVA81_13310 ENOG4105CKI cobalamin synthesis protein FVA81_13315 ENOG4105DZ1 carboxypeptidase FVA81_13365 ENOG4108Z9Z response to DNA damage stimulus FVA81_13380 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FVA81_13385 ENOG4107S1E Beta-lactamase FVA81_13390 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FVA81_13415 ENOG4105CFU surface antigen FVA81_13435 ENOG4107SDU Methyl-accepting chemotaxis FVA81_13440 ENOG4108V3W Chemotaxis protein, CheW FVA81_13445 ENOG4105HDK L-asparaginase FVA81_13450 ENOG4105FCD Major Facilitator FVA81_13460 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FVA81_13465 ENOG4108IEG Formate dehydrogenase Alpha subunit FVA81_13470 ENOG4107QIZ NADH dehydrogenase FVA81_13480 ENOG4105C5Q Transcriptional regulator FVA81_13490 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FVA81_13495 ENOG4105ETT transcriptional Regulator, LysR family FVA81_13500 ENOG4105C26 Dehydrogenase FVA81_13505 ENOG4105CXK mandelate racemase muconate lactonizing FVA81_13510 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FVA81_13515 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FVA81_13520 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FVA81_13525 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FVA81_13530 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FVA81_13535 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FVA81_13545 ENOG4105C25 Primosomal protein n' FVA81_13555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FVA81_13575 ENOG4107QN2 dihydrolipoyl dehydrogenase FVA81_13580 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FVA81_13595 ENOG4105C7S Dehydrogenase FVA81_13605 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FVA81_13610 ENOG4105CMV Succinyl-CoA synthetase subunit beta FVA81_13615 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FVA81_13620 ENOG4105D6Z AFG1 family ATPase FVA81_13625 ENOG4105YU5 Outer membrane lipoprotein FVA81_13630 ENOG4105E33 succinate dehydrogenase FVA81_13635 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FVA81_13645 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) FVA81_13670 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FVA81_13675 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FVA81_13680 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FVA81_13705 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FVA81_13720 ENOG410856B UPF0235 protein FVA81_13725 ENOG4105F0N pyrophosphate phospho-hydrolase FVA81_13740 ENOG4105DGW oligopeptidase A FVA81_13750 ENOG4105C2C drug resistance transporter, Bcr CflA FVA81_13755 ENOG4105CDH Citrulline--aspartate ligase FVA81_13765 ENOG4105X54 addiction module antidote protein FVA81_13780 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FVA81_13795 ENOG4105KZX Pterin carbinolamine dehydratase FVA81_13800 ENOG4105KJF protein tyrosine phosphatase FVA81_13805 ENOG4105M7V 2'-5' rna ligase FVA81_13815 ENOG4108I0Y (ABC) transporter FVA81_13825 ENOG4105HFZ Membrane FVA81_13830 ENOG4108VJ1 Transcriptional regulator (CarD family FVA81_13835 ENOG4108Z4U Ferredoxin FVA81_13840 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FVA81_13870 ENOG4105CHR reductase FVA81_13880 ENOG4108NVM synthesis repressor PhaR FVA81_13890 ENOG41082R8 50S ribosomal protein l32 FVA81_13900 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FVA81_13905 ENOG4105CTB Polyprenyl synthetase FVA81_13910 ENOG4105CIH Imidazole acetol-phosphate transaminase FVA81_13920 ENOG4108ZG0 Ompa motb domain protein FVA81_13925 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FVA81_13930 ENOG4106UW1 Major Facilitator superfamily FVA81_13935 ENOG4105DJP Membrane FVA81_13940 ENOG4105CH2 amidohydrolase FVA81_13945 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FVA81_13950 ENOG4105E2V Glycosyltransferase 36 FVA81_13955 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FVA81_13965 ENOG4105BZ1 (ABC) transporter FVA81_13970 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FVA81_13985 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FVA81_14005 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FVA81_14025 ENOG4107QZW Altronate oxidoreductase FVA81_14030 ENOG410617M Transcriptional regulator FVA81_14035 ENOG4105CTX dehydratase FVA81_14055 ENOG4105C2J ABC transporter FVA81_14065 ENOG4105CPQ Dehydrogenase FVA81_14070 ENOG4105FBA Phospholipase Carboxylesterase FVA81_14075 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FVA81_14080 ENOG4105CBN LysR family transcriptional regulator FVA81_14085 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FVA81_14090 ENOG4108WYP Transcriptional regulator FVA81_14130 ENOG4105ENV phosphonate C-P lyase system protein PhnK FVA81_14135 ENOG4105HRV phosphonate c-p lyase system protein phnl FVA81_14145 ENOG4105D5T phosphonate abc transporter FVA81_14150 ENOG4106AFQ Histidine kinase FVA81_14155 ENOG4105S7S phosphonate abc transporter FVA81_14165 ENOG4108TXN phosphonate metabolism protein FVA81_14170 ENOG4105FD8 phosphonate metabolism protein PhnM FVA81_14175 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FVA81_14180 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FVA81_14185 ENOG4105K46 50S ribosomal protein l27 FVA81_14205 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FVA81_14210 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FVA81_14215 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FVA81_14220 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FVA81_14230 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FVA81_14240 ENOG4105CN1 protease FVA81_14250 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FVA81_14270 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA FVA81_14275 ENOG4105C0B DNA polymerase III (alpha subunit) FVA81_14305 ENOG4105C5H ABC transporter FVA81_14320 ENOG4107T0D ABC, transporter FVA81_14325 ENOG4105ERG peptidase m48, ste24p FVA81_14330 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FVA81_14335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FVA81_14340 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FVA81_14345 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FVA81_14365 ENOG4105CVG Homoserine O-transsuccinylase FVA81_14390 ENOG4105K63 Thioredoxin FVA81_14400 ENOG4105W49 UPF0434 protein FVA81_14410 ENOG4105C29 acyl-CoA thioesterase FVA81_14415 ENOG4108YZA Nitrogen regulatory protein pii FVA81_14420 ENOG4105BZU Histidine kinase FVA81_14425 ENOG4105CNU cell division protein FtsK FVA81_14430 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FVA81_14445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FVA81_14460 ENOG4107R0W ABC transporter FVA81_14465 ENOG4105E5Q amino acid AbC transporter FVA81_14470 ENOG4105CSR polyphosphate kinase 2 FVA81_14475 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FVA81_14485 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FVA81_14495 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FVA81_14500 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FVA81_14505 ENOG4105K5M 30s ribosomal protein S16 FVA81_14510 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FVA81_14515 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FVA81_14525 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FVA81_14540 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FVA81_14550 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FVA81_14555 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FVA81_14560 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FVA81_14565 ENOG4107835 probably involved in intracellular septation (By similarity) FVA81_14570 ENOG4108VRQ UPF0314 protein FVA81_14585 ENOG41060IM Heme exporter protein FVA81_14590 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FVA81_14595 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FVA81_14600 ENOG4107QM5 aconitate hydratase FVA81_14610 ENOG4108RTU Aldolase FVA81_14615 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FVA81_14640 ENOG4108HWW ABC transporter FVA81_14650 ENOG4105DFW ABC transporter FVA81_14670 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FVA81_14680 ENOG4107B2H carbonic anhydrase FVA81_14690 ENOG4105C7I Dehydrogenase FVA81_14695 ENOG4105DEU major facilitator superfamily FVA81_14700 ENOG4105DC1 bifunctional purine biosynthesis protein purh FVA81_14710 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FVA81_14715 ENOG4105D0M Protease HtpX homolog FVA81_14730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FVA81_14740 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FVA81_14745 ENOG4105DFA alanine racemase domain protein FVA81_14750 ENOG4105C8T Leucyl-tRNA synthetase FVA81_14765 ENOG4105FA0 parb-like partition protein FVA81_14770 ENOG4107QJE Chromosome Partitioning Protein FVA81_14775 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) FVA81_14780 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FVA81_14785 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FVA81_14790 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FVA81_14795 ENOG4108YXA Membrane FVA81_14800 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FVA81_14805 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FVA81_14810 ENOG4108UHJ MAF-like protein FVA81_14815 ENOG4105E2X shikimate dehydrogenase FVA81_14820 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FVA81_14825 ENOG4108JDX DNA polymerase iii, epsilon subunit FVA81_14830 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FVA81_14860 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FVA81_14885 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FVA81_14890 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FVA81_14895 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FVA81_14900 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FVA81_14915 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FVA81_14925 ENOG4108S0S Nucleotidyl transferase FVA81_14930 ENOG4105EHM Aminoglycoside phosphotransferase FVA81_14935 ENOG4105I8F Histidine kinase FVA81_14940 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FVA81_14945 ENOG41080Z8 PHOSPHOCARRIER protein FVA81_14950 ENOG4108EQA pts system FVA81_14955 ENOG4107UZ6 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) FVA81_14960 ENOG4105EB3 Histidine kinase FVA81_14965 ENOG4105E3W Two component transcriptional regulator (Winged helix family FVA81_14970 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FVA81_14975 ENOG4108YZN class I peptide chain release factor FVA81_14980 ENOG4105CF1 Alkylated DNA repair protein FVA81_14985 ENOG4105CS9 pantothenic acid kinase FVA81_14990 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FVA81_14995 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FVA81_15000 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FVA81_15005 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FVA81_15010 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FVA81_15015 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FVA81_15020 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FVA81_15040 ENOG4107QP3 malate synthase g FVA81_15045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FVA81_15055 ENOG4108UYB regulatoR FVA81_15060 ENOG4105TX3 Histidine kinase FVA81_15065 ENOG4105CQ7 ATP-dependent helicase FVA81_15070 ENOG4105CIF Ornithine Cyclodeaminase FVA81_15105 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FVA81_15110 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FVA81_15120 ENOG4105CNN ABC, transporter FVA81_15125 ENOG4105C2J ABC transporter FVA81_15140 ENOG4105CMD Transcriptional regulator, GntR family FVA81_15145 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FVA81_15150 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FVA81_15155 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FVA81_15165 ENOG4108UAU isochorismatase FVA81_15170 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FVA81_15175 ENOG4105CHR reductase FVA81_15180 ENOG4105C2J ABC transporter FVA81_15185 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FVA81_15190 ENOG4105CNN ABC, transporter FVA81_15195 ENOG4108HHA Transketolase FVA81_15200 ENOG4108IUS Transketolase FVA81_15205 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FVA81_15210 ENOG4105DKT Transcriptional regulator FVA81_15215 ENOG4105CHR reductase FVA81_15230 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FVA81_15235 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FVA81_15240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_15245 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FVA81_15255 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FVA81_15270 ENOG4108IFG nitrite reductase, (NAD(P)H) FVA81_15275 ENOG4105D7T ABC transporter FVA81_15290 ENOG4105I5W Transporter FVA81_15300 ENOG4105CSH Transporter FVA81_15305 ENOG4105E2S oxidase) subunit II FVA81_15310 ENOG4105BZ9 Cytochrome C oxidase, subunit I FVA81_15315 ENOG4105CCU oxidase (Subunit III) FVA81_15320 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FVA81_15340 ENOG4105UIB (ABC) transporter FVA81_15350 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) FVA81_15360 ENOG4108JQ9 ABC transporter FVA81_15365 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FVA81_15375 ENOG4105CZE histidine utilization repressor FVA81_15385 ENOG4105CGP Urocanate hydratase FVA81_15395 ENOG4105C84 Histidine ammonia-lyase FVA81_15400 ENOG4105CI2 imidazolone-5-propionate hydrolase FVA81_15410 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FVA81_15425 ENOG4105DEI Mannitol dehydrogenase FVA81_15430 ENOG4105CHR reductase FVA81_15435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_15470 ENOG4105E0A ABC, transporter FVA81_15480 ENOG4105EHG Permease protein FVA81_15485 ENOG4105E98 transcriptional regulator DeoR family FVA81_15490 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FVA81_15495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_15500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_15510 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FVA81_15530 ENOG4107T0X DNA ligase FVA81_15545 ENOG4108NIX Factor ChrR FVA81_15550 ENOG4105K6V RNA polymerase FVA81_15565 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FVA81_15570 ENOG4105CHR reductase FVA81_15580 ENOG4107U9H DNA polymerase FVA81_15600 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FVA81_15605 ENOG4105CAT Cytidine monophosphate kinase FVA81_15645 ENOG4105EN6 Membrane FVA81_15655 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FVA81_15680 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FVA81_15685 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FVA81_15690 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FVA81_15695 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FVA81_15700 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FVA81_15710 ENOG4105CHV Transcription elongation factor NusA FVA81_15715 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FVA81_15720 ENOG4107SFI Major Facilitator superfamily FVA81_15730 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FVA81_15745 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FVA81_15750 ENOG4107QMP dna polymerase iii subunits gamma and tau FVA81_15765 ENOG4105E09 nadh pyrophosphatase FVA81_15770 ENOG4105CQC Prephenate dehydratase FVA81_15775 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FVA81_15780 ENOG4105G9V cytochrome C FVA81_15815 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FVA81_15825 ENOG41069P5 Protein slyX homolog FVA81_15840 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FVA81_15850 ENOG4105CFG Acts as a chaperone (By similarity) FVA81_15855 ENOG4108JQC penicillin-binding protein 1A FVA81_15860 ENOG4108UIN ybak prolyl-trna synthetase associated region FVA81_15875 ENOG4105C2M dna polymerase I FVA81_15885 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FVA81_15890 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FVA81_15900 ENOG4105CHC glucokinase (EC 2.7.1.2) FVA81_15905 ENOG4108Z5K methylglyoxal synthase FVA81_15910 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) FVA81_15920 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FVA81_15925 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FVA81_15940 ENOG4108JQ5 ABC transporter FVA81_15955 ENOG4107RH7 Nicotinate phosphoribosyltransferase FVA81_16025 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FVA81_16030 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FVA81_16035 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FVA81_16045 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FVA81_16050 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FVA81_16055 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FVA81_16075 ENOG4108JQ9 ABC transporter FVA81_16080 ENOG4105DIH basic membrane FVA81_16085 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FVA81_16110 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) FVA81_16115 ENOG41080QX K07048 phosphotriesterase-related protein FVA81_16135 ENOG4105E5Q amino acid AbC transporter FVA81_16140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_16150 ENOG4105CDA abc transporter atp-binding protein FVA81_16175 ENOG4105VP2 Transcriptional regulator, Crp Fnr family FVA81_16185 ENOG4105CAQ asparagine synthetase FVA81_16190 ENOG4105D9M gamma-glutamylcysteine synthetase FVA81_16225 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FVA81_16235 ENOG4107SN7 NLP P60 protein FVA81_16275 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FVA81_16290 ENOG4106YAV Domain of unknown function (DUF1508) FVA81_16320 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FVA81_16325 ENOG4105GRZ Ycii-related protein FVA81_16330 ENOG4105CHP RNA polymerase FVA81_16350 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FVA81_16380 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FVA81_16390 ENOG4105CPQ Dehydrogenase FVA81_16395 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FVA81_16440 ENOG4105CH5 extracellular solute-binding protein, family 7 FVA81_16455 ENOG4105DCM major facilitator superfamily FVA81_16465 ENOG4105EV9 Alpha Beta Hydrolase FVA81_16470 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FVA81_16485 ENOG4105ETX regulatoR FVA81_16490 ENOG4105DHQ Histidine kinase FVA81_16495 ENOG41082BR 50S ribosomal protein L35 FVA81_16500 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FVA81_16510 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FVA81_16520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FVA81_16525 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FVA81_16530 ENOG4105E0A ABC, transporter FVA81_16535 ENOG4105EHG Permease protein FVA81_16545 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FVA81_16550 ENOG4105T38 integral membrane protein FVA81_16555 ENOG4107SET aldo keto reductase FVA81_16560 ENOG4105CPC Aldo Keto reductase FVA81_16575 ENOG410838F Glycosyl transferase family 2 FVA81_16585 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FVA81_16590 ENOG4108X0B nad(p)h dehydrogenase (quinone) FVA81_16615 ENOG4105C88 aminopeptidase FVA81_16625 ENOG4108Z66 YbaK ebsC protein FVA81_16630 ENOG4105KUZ arsenate reductase FVA81_16645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FVA81_16660 ENOG4105KAV tspo and mbr like protein FVA81_16685 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FVA81_16690 ENOG4105K6T rare lipoprotein A FVA81_16700 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FVA81_16710 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FVA81_16725 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FVA81_16740 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FVA81_16745 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FVA81_16750 ENOG41082FP UPF0102 protein FVA81_16770 ENOG4108IJ9 (ABC) transporter FVA81_16780 ENOG4105D7Z glutathione synthase FVA81_16785 ENOG4105C0P Mg chelatase subunit ChlI FVA81_16790 ENOG410903D sensor protein FVA81_16805 ENOG4105N14 lysine exporter protein LysE YggA FVA81_16820 ENOG4108YXU transcriptional regulator AsnC family FVA81_16825 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FVA81_16830 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FVA81_16840 ENOG4107VXZ Hydrolase FVA81_16845 ENOG4105DWF phosphomethylpyrimidine kinase FVA81_16850 ENOG4105EUB pirin domain protein FVA81_16865 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FVA81_16870 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_16875 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FVA81_16880 ENOG4105BZU Histidine kinase FVA81_16885 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FVA81_16890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FVA81_16895 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FVA81_16900 ENOG4105E39 Enoyl-CoA hydratase FVA81_16905 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FVA81_16910 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FVA81_16915 ENOG4105DXX methyltransferase FVA81_16920 ENOG4105CSA Coproporphyrinogen iii oxidase FVA81_16925 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FVA81_16935 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FVA81_16940 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FVA81_16945 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FVA81_16950 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FVA81_16955 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea FVA81_16960 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FVA81_16965 ENOG4108IUZ ABC transporter FVA81_16970 ENOG4105RF0 OstA family FVA81_16980 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FVA81_16990 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FVA81_16995 ENOG4108RWN rrna methyltransferase FVA81_17000 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FVA81_17020 ENOG4105C6K Malic enzyme FVA81_17025 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FVA81_17030 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FVA81_17045 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FVA81_17050 ENOG4105C31 Tryptophanyl-tRNA synthetase FVA81_17060 ENOG41083MR nifu domain-containing protein FVA81_17065 ENOG41072GX Peptidase M22 Glycoprotease FVA81_17070 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FVA81_17075 ENOG41090R7 Ferric uptake FVA81_17085 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FVA81_17090 ENOG4105C9A Phoh family FVA81_17095 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FVA81_17105 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FVA81_17110 ENOG4108WRK Transcriptional regulator FVA81_17115 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FVA81_17120 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FVA81_17135 ENOG4105DU0 nucleoside hydrolase FVA81_17140 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_17145 ENOG4108RVA ribokinase FVA81_17155 ENOG4105UT3 Methyl-accepting chemotaxis FVA81_17160 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_17165 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FVA81_17170 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FVA81_17175 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FVA81_17185 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FVA81_17195 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FVA81_17225 ENOG4105CAS nag kinase FVA81_17245 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FVA81_17255 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FVA81_17260 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FVA81_17270 ENOG4105BZU Histidine kinase FVA81_17280 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FVA81_17285 ENOG4105CTU Proline racemase FVA81_17290 ENOG4105IJJ transcriptional regulator, crp fnr family FVA81_17305 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator FVA81_17310 ENOG4105CNN ABC, transporter FVA81_17315 ENOG4105C2J ABC transporter FVA81_17325 ENOG4108VYJ response regulator receiver protein FVA81_17335 ENOG4105BZU Histidine kinase FVA81_17340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FVA81_17345 ENOG4105EKE dihydroorotase FVA81_17360 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FVA81_17375 ENOG4106A2Z transcriptional regulator antitoxin, MazE FVA81_17400 ENOG4107QP8 phosphohexose isomerase FVA81_17405 ENOG4105CEY Amp-dependent synthetase and ligase FVA81_17435 ENOG4105CSR polyphosphate kinase 2 FVA81_17440 ENOG4105BZU Histidine kinase FVA81_17460 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FVA81_17465 ENOG4108UTW Plays a role in the regulation of phosphate uptake FVA81_17470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FVA81_17480 ENOG4105C8Y Acetylornithine aminotransferase FVA81_17485 ENOG4105DBV ornithine carbamoyltransferase FVA81_17490 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FVA81_17500 ENOG4105NWN ApaG protein FVA81_17510 ENOG4105DHP deoxycytidine triphosphate deaminase FVA81_17520 ENOG4108YYH Nadph-dependent fmn reductase FVA81_17570 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FVA81_17575 ENOG4107R73 Mate efflux family protein FVA81_17600 ENOG4107QRT dEAD DEAH box helicase FVA81_17610 ENOG4105NAE bifunctional deaminase-reductase domain protein FVA81_17635 ENOG4105CSU acyl-Coa dehydrogenase FVA81_17640 ENOG4105CHU acetyl-coa acetyltransferase FVA81_17650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FVA81_17655 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FVA81_17660 ENOG4108HKT sucrose-6-phosphate hydrolase FVA81_17665 ENOG4105BZU Histidine kinase FVA81_17670 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FVA81_17685 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FVA81_17700 ENOG41066YJ Beta-lactamase FVA81_17715 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FVA81_17725 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FVA81_17730 ENOG4108ZTZ UPF0262 protein FVA81_17740 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FVA81_17745 ENOG4108Z03 MAF-like protein FVA81_17770 ENOG410903D sensor protein FVA81_17775 ENOG4105BZU Histidine kinase FVA81_17805 ENOG4108IQI permease FVA81_17815 ENOG4105CVJ phosphoglycerate mutase FVA81_17820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_17825 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component FVA81_17835 ENOG4108Q3X Transcriptional regulator FVA81_17840 ENOG4106D4I domain protein FVA81_17845 ENOG4107VRP DNA repair exonuclease FVA81_17880 ENOG4105DEF Extracellular solute-binding protein, family 5 FVA81_17885 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FVA81_17890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_17895 ENOG4105C3U ABC transporter FVA81_17900 ENOG4108JQ7 (ABC) transporter FVA81_17910 ENOG4105EW9 transcriptional regulator AsnC family FVA81_17915 ENOG4105CGF Aromatic amino acid aminotransferase FVA81_17925 ENOG4105E0A ABC, transporter FVA81_17930 ENOG4105EHG Permease protein FVA81_17945 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FVA81_17950 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FVA81_17990 ENOG4105EIG urea carboxylase-associated protein 1 FVA81_17995 ENOG4105EIG urea carboxylase-associated protein 1 FVA81_18015 ENOG4105CNN ABC, transporter FVA81_18025 ENOG4105C2J ABC transporter FVA81_18030 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FVA81_18035 ENOG4105BZU Histidine kinase FVA81_18055 ENOG4107QWB Ornithine cyclodeaminase FVA81_18060 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_18070 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FVA81_18075 ENOG4105GAK amidohydrolase 2 FVA81_18080 ENOG4105CXK mandelate racemase muconate lactonizing FVA81_18085 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase FVA81_18090 ENOG4107YCY Transcriptional regulator FVA81_18095 ENOG4105E9Z Nad-dependent epimerase dehydratase FVA81_18125 ENOG4108JJA ABC, transporter FVA81_18130 ENOG4105C42 Type I secretion membrane fusion protein (HlyD FVA81_18155 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FVA81_18165 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FVA81_18180 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FVA81_18230 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase FVA81_18240 ENOG4108JIK carboxylase FVA81_18245 ENOG4105P4J Allophanate hydrolase, subunit 1 FVA81_18250 ENOG4105CFM UPF0317 protein FVA81_18255 ENOG4105E7W lamb ycsf family protein FVA81_18260 ENOG4105C5A transporter FVA81_18265 ENOG4105DRR Transcriptional regulator, GntR family FVA81_18290 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FVA81_18305 ENOG4105BZU Histidine kinase FVA81_18330 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FVA81_18340 ENOG4105FDF Could be involved in DNA repair (By similarity) FVA81_18345 ENOG4105DQE DNA ligase FVA81_18355 ENOG4105UT3 Methyl-accepting chemotaxis FVA81_18365 ENOG4108VYJ response regulator receiver protein FVA81_18370 ENOG4105CBS Chea signal transduction histidine kinase FVA81_18375 ENOG4108V3W Chemotaxis protein, CheW FVA81_18380 ENOG4105BZU Histidine kinase FVA81_18385 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FVA81_18390 ENOG4108VYJ response regulator receiver protein FVA81_18395 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FVA81_18405 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FVA81_18410 ENOG4105VJY transcriptional regulator FVA81_18420 ENOG4105QDQ FVA81_18425 ENOG4105D00 flagellar biosynthetic protein flhB FVA81_18430 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FVA81_18435 ENOG4105DD5 Flagellar motor switch protein FVA81_18445 ENOG4107RD7 Flagellar Motor Protein, MotA FVA81_18450 ENOG4105KTQ flagellar basal-body rod protein FVA81_18455 ENOG4108JIR Flagellum-specific ATP synthase FVA81_18465 ENOG4105SFI flagellar basal-body rod protein FVA81_18470 ENOG4108ZC9 flagellar basal-body rod protein flgc FVA81_18475 ENOG4105X50 flagellar hook-basal body complex protein fliE FVA81_18480 ENOG4105CGA flagellar basal-body rod protein FlgG FVA81_18485 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA FVA81_18490 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FVA81_18500 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FVA81_18510 ENOG4105CN7 Flagellar biosynthetic protein FliP FVA81_18515 ENOG4107W75 Flagellin FVA81_18530 ENOG4107W75 Flagellin FVA81_18535 ENOG4107W75 Flagellin FVA81_18545 ENOG4105ER2 Ompa motb domain protein FVA81_18550 ENOG4108S15 chemotaxis, protein FVA81_18570 ENOG4105BZE flagellar hook protein, FlgE FVA81_18575 ENOG4105E1Q flagellar hook-associated protein FVA81_18590 ENOG4105KHD Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation (By similarity) FVA81_18595 ENOG410822I Flagellar hook capping protein FVA81_18605 ENOG4105D7B Flagellar biosynthesis protein flha FVA81_18610 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FVA81_18640 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FVA81_18645 ENOG4105FKQ transcriptional regulator FVA81_18650 ENOG4105EPJ extracellular solute-binding protein family 1 FVA81_18655 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component FVA81_18660 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component FVA81_18665 ENOG4105CG3 alpha amylase, catalytic region FVA81_18670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_18680 ENOG4105CHR reductase FVA81_18700 ENOG4108WQI RNA Polymerase FVA81_18710 ENOG4107SDU Methyl-accepting chemotaxis FVA81_18715 ENOG4105C01 Dihydroxy-acid dehydratase FVA81_18720 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) FVA81_18725 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FVA81_18730 ENOG4105CJP fad dependent oxidoreductase FVA81_18740 ENOG4105CBX hi0933 family FVA81_18775 ENOG4107RUE extracellular solute-binding protein family 1 FVA81_18780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FVA81_18785 ENOG4105F38 ABC transporter, permease FVA81_18790 ENOG4105D38 putrescine abc transporter FVA81_18805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FVA81_18810 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component FVA81_18825 ENOG4105E3W Two component transcriptional regulator (Winged helix family FVA81_18830 ENOG41065SU Two-component system sensor kinase FVA81_18855 ENOG4105CM2 brancheD-chain amino acid aminotransferase FVA81_18870 ENOG4108Z40 Transcriptional regulator FVA81_18880 ENOG4105C26 Dehydrogenase FVA81_18890 ENOG4108M3P Membrane FVA81_18895 ENOG4105ERG peptidase m48, ste24p FVA81_18905 ENOG4105KPV Transcriptional regulator FVA81_18915 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FVA81_18925 ENOG4105CJP fad dependent oxidoreductase FVA81_18930 ENOG4105CFQ glutamine synthetase FVA81_18940 ENOG4105WD1 Membrane FVA81_18960 ENOG4105BZ9 Cytochrome C oxidase, subunit I FVA81_18965 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FVA81_18990 ENOG4105C2J ABC transporter FVA81_18995 ENOG4105CNN ABC, transporter FVA81_19000 ENOG4105DKT Transcriptional regulator FVA81_19005 ENOG4108FN7 Aldo keto reductase FVA81_19015 ENOG41061GT Aldolase FVA81_19020 ENOG4105CMG Carbohydrate kinase FVA81_19040 ENOG41062D9 Histidine kinase FVA81_19045 ENOG4105XJC Two component transcriptional regulator (Winged helix family FVA81_19065 ENOG4105DIJ Phosphoethanolamine transferase FVA81_19075 ENOG4105D65 subunit l FVA81_19080 ENOG4108ZE9 Monovalent cation H antiporter subunit C FVA81_19085 ENOG4107R4Z monovalent cation h antiporter subunit d FVA81_19090 ENOG4105SC1 monovalent cation H antiporter subunit E FVA81_19095 ENOG4105W4C monovalent cation H antiporter subunit F FVA81_19100 ENOG4105KJM monovalent cation h antiporter subunit g FVA81_19115 ENOG4105E0K tonB-dependent siderophore receptor FVA81_19120 ENOG4105J76 Periplasmic binding protein FVA81_19125 ENOG4105S6R Iron-hydroxamate transporter permease subunit FVA81_19135 ENOG4105E0A ABC, transporter FVA81_19165 ENOG41061MD high-affinity nickel-transporter FVA81_19175 ENOG4105C3U ABC transporter FVA81_19180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_19195 ENOG4105MRR Transcriptional regulator (By similarity) FVA81_19200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FVA81_19210 ENOG4105KJM monovalent cation h antiporter subunit g FVA81_19225 ENOG4108JPZ Monovalent cation H antiporter subunit D FVA81_19230 ENOG4105MKQ Monovalent cation H antiporter subunit C FVA81_19235 ENOG4105GND monovalent cation H antiporter subunit B FVA81_19240 ENOG4105D65 subunit l FVA81_19245 ENOG4105BZU Histidine kinase FVA81_19250 ENOG4108XFH Transcriptional regulator FVA81_19255 ENOG4105EMU Dehydrogenase FVA81_19265 ENOG4105CIS alcohol dehydrogenase FVA81_19290 ENOG4105C08 Histidine kinase FVA81_19305 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FVA81_19310 ENOG4105E39 Enoyl-CoA hydratase FVA81_19315 ENOG4105C26 Dehydrogenase FVA81_19320 ENOG4108JP0 extracellular solute-binding protein family 1 FVA81_19325 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FVA81_19335 ENOG4108IJ9 (ABC) transporter FVA81_19345 ENOG4105CHR reductase FVA81_19365 ENOG4105ETE Transcriptional regulator (LacI family FVA81_19405 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FVA81_19420 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FVA81_19445 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FVA81_19455 ENOG4106WR0 acetolactate synthase (large subunit) FVA81_19500 ENOG4105D64 Mechanosensitive ion channel FVA81_19530 ENOG4108Z9Z response to DNA damage stimulus FVA81_19550 ENOG4105BZU Histidine kinase FVA81_19590 ENOG4108REF Sporulation integral membrane protein ytvi FVA81_19600 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FVA81_19610 ENOG4108HWV )-transporter FVA81_19630 ENOG4105ETE Transcriptional regulator (LacI family FVA81_19650 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FVA81_19660 ENOG4105C7F AcnD-accessory protein PrpF FVA81_19690 ENOG4107Z3H Transcriptional regulator, TetR family FVA81_19705 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FVA81_19720 ENOG4108KB1 transcriptional regulator, arac family FVA81_19740 ENOG41088T4 Helicase IV FVA81_19760 ENOG4105C9X ppx gppa phosphatase FVA81_19765 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FVA81_19775 ENOG4105C0R drug resistance transporter emrb qaca subfamily FVA81_19805 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FVA81_19825 ENOG4108IG5 Transcriptional regulator FVA81_19840 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_19865 ENOG4105CJ3 phosphate transporter FVA81_19875 ENOG4108E2B had-superfamily hydrolase, subfamily iib FVA81_19880 ENOG4107STW synthase FVA81_19885 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FVA81_19890 ENOG4107QR9 Iron-sulfur cluster binding protein FVA81_19895 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FVA81_19900 ENOG4105JXH GntR family transcriptional regulator FVA81_19915 ENOG4105HEI LysR family (Transcriptional regulator FVA81_19920 ENOG4105CQB FAD linked oxidase domain protein FVA81_19925 ENOG4105EU8 FAD linked oxidase domain protein FVA81_19935 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FVA81_19945 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FVA81_19950 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FVA81_19955 ENOG4108R3E Dna-3-methyladenine glycosylase i FVA81_19990 ENOG4105CUT histidyl-tRNA synthetase FVA81_20000 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit FVA81_20005 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FVA81_20015 ENOG4108VBZ doxx family FVA81_20030 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FVA81_20035 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FVA81_20055 ENOG4105DTN riboflavin biosynthesis protein ribF FVA81_20065 ENOG4105BZU Histidine kinase FVA81_20070 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FVA81_20080 ENOG4105K5X acetyltransferase FVA81_20090 ENOG4108Z6B deaminase FVA81_20095 ENOG4105FE9 pseudouridine synthase FVA81_20100 ENOG4106H78 methyltransferase FVA81_20105 ENOG4105D78 K07001 NTE family protein FVA81_20110 ENOG4105CKD glutathione-regulated potassium-efflux system protein FVA81_20115 ENOG4105CMS peptidase U62, modulator of DNA gyrase FVA81_20130 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FVA81_20140 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FVA81_20150 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FVA81_20155 ENOG4105BZU Histidine kinase FVA81_20160 ENOG4105BZU Histidine kinase FVA81_20165 ENOG4105ETT transcriptional Regulator, LysR family FVA81_20170 ENOG4105F5V trimethylamine methyltransferase FVA81_20185 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FVA81_20190 ENOG4107WYG Transcriptional regulator, luxr family FVA81_20200 ENOG4107QUT magnesium and cobalt transport protein CorA FVA81_20205 ENOG4105DFH Transport of potassium into the cell (By similarity) FVA81_20215 ENOG4107PQ6 Inherit from NOG: atp synthase FVA81_20220 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FVA81_20225 ENOG4105VD1 ATP synthase subunit C FVA81_20230 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FVA81_20235 ENOG4105N5Q Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FVA81_20245 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FVA81_20260 ENOG4108RIR Molybdenum cofactor biosynthesis protein FVA81_20265 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FVA81_20270 ENOG4105RT1 May be involved in cell division (By similarity) FVA81_20275 ENOG4105EAH synthase FVA81_20300 ENOG4105BZU Histidine kinase FVA81_20305 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FVA81_20310 ENOG4105YES addiction module antidote protein FVA81_20320 ENOG4108V0P LemA family FVA81_20325 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FVA81_20335 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FVA81_20340 ENOG4105VDM plasmid maintenance system antidote protein, xre family FVA81_20345 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FVA81_20360 ENOG4105EWC Purine nucleoside phosphorylase FVA81_20365 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_20375 ENOG4105C12 Phosphoribosylglycinamide synthetase FVA81_20380 ENOG4105BZM domain protein FVA81_20395 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FVA81_20410 ENOG4105TAV cytochrome C FVA81_20415 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FVA81_20445 ENOG4105W1Y Transcriptional regulator FVA81_20470 ENOG4105Z4Q MltA-interacting MipA family protein FVA81_20475 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FVA81_20490 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FVA81_20495 ENOG4105E0C molybdate abc transporter FVA81_20500 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FVA81_20505 ENOG4105F4R Transcriptional regulator mode FVA81_20510 ENOG4105CQB FAD linked oxidase domain protein FVA81_20515 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FVA81_20530 ENOG4105DVW rieske (2Fe-2S) FVA81_20540 ENOG4105W6J BA14K family FVA81_20550 ENOG4107QMS site-determining protein FVA81_20555 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FVA81_20565 ENOG4105CSU acyl-Coa dehydrogenase FVA81_20575 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_20590 ENOG4107QS4 23S rRNA FVA81_20610 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FVA81_20615 ENOG4105DU1 integral membrane protein, terc FVA81_20620 ENOG4108J5H Homocysteine s-methyltransferase FVA81_20625 ENOG4105C28 cystathionine FVA81_20635 ENOG4105DSP amino acid AbC transporter FVA81_20645 ENOG4108JEH abc transporter atp-binding protein FVA81_20670 ENOG4105EUB pirin domain protein FVA81_20675 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FVA81_20705 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FVA81_20720 ENOG4107ZYJ bioY protein FVA81_20725 ENOG4107QCX Transporter FVA81_20730 ENOG4108JJB ABC transporter FVA81_20735 ENOG4105T0Z Conserved Protein FVA81_20755 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FVA81_20760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FVA81_20765 ENOG4105BZU Histidine kinase FVA81_20775 ENOG4105CVJ phosphoglycerate mutase FVA81_20780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FVA81_20785 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FVA81_20795 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FVA81_20810 ENOG4108Z4X TRANSCRIPTIONal FVA81_20815 ENOG4105DZ1 carboxypeptidase FVA81_20830 ENOG4105D1U peptidase U62 modulator of DNA gyrase FVA81_20840 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FVA81_20845 ENOG4105BZ9 Cytochrome C oxidase, subunit I FVA81_20850 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FVA81_20860 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) FVA81_20865 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FVA81_20875 ENOG4108R6F Surfeit locus 1 family protein FVA81_20885 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FVA81_20900 ENOG4105CUV Homoserine Kinase FVA81_20905 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FVA81_20915 ENOG4105EHV domain protein FVA81_20925 ENOG4108UJU UPF0301 protein FVA81_20945 ENOG4105BZU Histidine kinase FVA81_20950 ENOG4105D9U N-acetyltransferase FVA81_20955 ENOG4105C1V Peptidase, M16 FVA81_20960 ENOG4105D98 threonine synthase FVA81_20980 ENOG4105CBD Diacylglycerol kinase FVA81_20985 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FVA81_21020 ENOG41080Y5 BioY family FVA81_21030 ENOG4105BZU Histidine kinase FVA81_21050 ENOG4105CEC DNA methylase N-4 N-6 FVA81_21055 ENOG4105KCK Peptidoglycan-associated lipoprotein FVA81_21065 ENOG4105CEN a g-specific adenine glycosylase FVA81_21075 ENOG4105F8J Adenylate Guanylate cyclase FVA81_21090 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FVA81_21110 ENOG4106UW1 Major Facilitator superfamily FVA81_21120 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FVA81_21125 ENOG4105YES addiction module antidote protein FVA81_21145 ENOG4107FW0 short-chain dehydrogenase reductase FVA81_21160 ENOG4108W6C Dehydrogenase FVA81_21190 ENOG4108Z0Z intracellular protease Pfpi family FVA81_21200 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FVA81_21205 ENOG4105BZ1 (ABC) transporter FVA81_21220 ENOG4105BZU Histidine kinase FVA81_21240 ENOG4105DIQ Transcriptional regulator FVA81_21255 ENOG4107QK2 May be the GTPase, regulating ATP sulfurylase activity (By similarity) FVA81_21260 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FVA81_21265 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FVA81_21270 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family FVA81_21300 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FVA81_21305 ENOG4105CHH sulfate transporter FVA81_21350 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FVA81_21380 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FVA81_21385 ENOG4105C26 Dehydrogenase FVA81_21390 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FVA81_21395 ENOG4108M8H domain protein FVA81_21400 ENOG4107W75 Flagellin FVA81_21415 ENOG4105BZU Histidine kinase FVA81_21475 ENOG4105BZU Histidine kinase FVA81_21495 ENOG4105C0R drug resistance transporter emrb qaca subfamily FVA81_21500 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_21505 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FVA81_21510 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FVA81_21530 ENOG4105K56 Transcriptional regulator FVA81_21535 ENOG4108ZHJ Organic hydroperoxide resistance protein FVA81_21545 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FVA81_21570 ENOG4105K5G 30S ribosomal protein S21 FVA81_21575 ENOG4105VEQ Cold shock protein FVA81_21585 ENOG4105ECK Fatty Acid Desaturase FVA81_21595 ENOG4108NIW Leucine export protein LeuE FVA81_21600 ENOG4105KY5 gCN5-related N-acetyltransferase FVA81_21635 ENOG4105D7A ATP-binding protein FVA81_21650 ENOG4107SDU Methyl-accepting chemotaxis FVA81_21665 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FVA81_21690 ENOG4105W39 Membrane FVA81_21715 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FVA81_21720 ENOG4108HWW ABC transporter FVA81_21725 ENOG4105C2J ABC transporter FVA81_21750 ENOG4108UT2 hemolysin iii FVA81_21765 ENOG410829K Lysine exporter protein (Lyse ygga) FVA81_21775 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FVA81_21800 ENOG4105C9U ATP-dependent DNA helicase RecQ FVA81_21820 ENOG4105E0X reductase FVA81_21825 ENOG4105D65 subunit l FVA81_21830 ENOG4105HC0 Na H antiporter FVA81_21835 ENOG4108ZE9 Monovalent cation H antiporter subunit C FVA81_21840 ENOG4108JPZ Monovalent cation H antiporter subunit D FVA81_21845 ENOG4105SC1 monovalent cation H antiporter subunit E FVA81_21850 ENOG41080TA Multiple resistance and ph regulation protein f FVA81_21855 ENOG4105KJM monovalent cation h antiporter subunit g FVA81_21860 ENOG4108YXV Transcriptional regulator FVA81_21885 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FVA81_21895 ENOG4105WZR FVA81_21900 ENOG4105BZU Histidine kinase FVA81_21910 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_21920 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression FVA81_21940 ENOG4105CPI Metal Dependent Phosphohydrolase FVA81_21965 ENOG4105KWG Pfam:DUF1696 FVA81_22000 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FVA81_22020 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FVA81_22030 ENOG4105BZU Histidine kinase FVA81_22035 ENOG4108JQC penicillin-binding protein 1A FVA81_22040 ENOG4108ZZ3 UPF0260 protein FVA81_22080 ENOG4106TD9 Diguanylate cyclase FVA81_22200 ENOG4105ZGE Toxic component of a toxin-antitoxin (TA) module. A FVA81_22255 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression FVA81_22265 ENOG4105XJC Two component transcriptional regulator (Winged helix family FVA81_22270 ENOG4105E0F Histidine kinase FVA81_22280 ENOG4106FI7 cytochrome c-type biogenesis protein FVA81_22285 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FVA81_22290 ENOG4105DA4 cytochrome c-type biogenesis protein FVA81_22295 ENOG4105KWW Biogenesis protein FVA81_22305 ENOG4105C0H protease FVA81_22310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FVA81_22315 ENOG4105GR3 Histidine kinase FVA81_22320 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FVA81_22325 ENOG4108MX3 Polysaccharide Biosynthesis Protein FVA81_22330 ENOG4105BZU Histidine kinase FVA81_22335 ENOG4105CD8 aminopeptidase N FVA81_22340 ENOG4105C8Q Methyl-accepting chemotaxis FVA81_22370 ENOG4105CFG Acts as a chaperone (By similarity) FVA81_22385 ENOG4105CHR reductase FVA81_22395 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FVA81_22400 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FVA81_22405 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FVA81_22410 ENOG4105KVH Transcriptional regulator FVA81_22420 ENOG4105KVH Transcriptional regulator FVA81_22425 ENOG4105F27 Major Facilitator FVA81_22435 ENOG4108JQ5 ABC transporter FVA81_22440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FVA81_22445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FVA81_22450 ENOG4107QSI ABC, transporter FVA81_22455 ENOG4105CFQ glutamine synthetase FVA81_22460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FVA81_22470 ENOG4105CHR reductase FVA81_22490 ENOG4105EQ2 LysR family Transcriptional regulator FVA81_22495 ENOG4105CPC Aldo Keto reductase FVA81_22500 ENOG4105FYV Amp nucleosidase FVA81_22520 ENOG4105CIH Imidazole acetol-phosphate transaminase FVA81_22565 ENOG4107SC1 transglycosylase FVA81_22570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_22585 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FVA81_22595 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FVA81_22605 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FVA81_22625 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FVA81_22630 ENOG4105C3F Signal peptidase i FVA81_22635 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FVA81_22640 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FVA81_22645 ENOG4108KK1 membrane protein AbrB duplication FVA81_22655 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) FVA81_22670 ENOG4105QVC MOSC domain-containing protein FVA81_22675 ENOG4105EST Metal Dependent Phosphohydrolase FVA81_22685 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FVA81_22690 ENOG4108IYU L-aspartate oxidase FVA81_22695 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FVA81_22705 ENOG4105D64 Mechanosensitive ion channel FVA81_22720 ENOG4108R7K Metal Dependent Phosphohydrolase FVA81_22755 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FVA81_22760 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme FVA81_22765 ENOG4105BZU Histidine kinase FVA81_22770 ENOG4108JJ7 ABC transporter FVA81_22780 ENOG4108URH decarboxylase FVA81_22790 ENOG4105HEI LysR family (Transcriptional regulator FVA81_22795 ENOG4105F27 Major Facilitator FVA81_22800 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FVA81_22820 ENOG4105C8N cysteinyl-tRNA synthetase FVA81_22825 ENOG4105BZU Histidine kinase FVA81_22830 ENOG4105FDR Membrane FVA81_22835 ENOG4105PDP Short chain dehydrogenase FVA81_22840 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FVA81_22845 ENOG4105E96 Colicin v production protein FVA81_22865 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FVA81_22870 ENOG4105E7U AraC family transcriptional regulator FVA81_22890 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FVA81_22900 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FVA81_22905 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FVA81_22920 ENOG4105CPC Aldo Keto reductase FVA81_22925 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FVA81_22935 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FVA81_22940 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FVA81_22945 ENOG4105HHA aminodeoxychorismate lyase FVA81_22950 ENOG4105DSJ YicC domain protein FVA81_22955 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FVA81_22960 ENOG4105CBG Sulfatase FVA81_22975 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FVA81_22980 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FVA81_22990 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FVA81_23005 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FVA81_23030 ENOG4105C5H ABC transporter FVA81_23050 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FVA81_23070 ENOG4108ZAF Molybdopterin FVA81_23085 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FVA81_23090 ENOG4105CHR reductase FVA81_23095 ENOG4105JVC membrAne FVA81_23105 ENOG41083KI ribonuclease, T2 FVA81_23110 ENOG4105D6S protein involved in catabolism of external DNA FVA81_23115 ENOG4108J2R molybdopterin oxidoreductase FVA81_23120 ENOG4107VIJ nudix hydrolase FVA81_23125 ENOG4105BZ1 (ABC) transporter FVA81_23135 ENOG4108V3E phosphoribosylglycinamide formyltransferase FVA81_23140 ENOG4105CXB phosphoribosylaminoimidazole synthetase FVA81_23145 ENOG4105C02 permease FVA81_23155 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FVA81_23160 ENOG4105C9X ppx gppa phosphatase FVA81_23190 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FVA81_23230 ENOG4105C9M aspartyl-trna synthetase FVA81_23240 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FVA81_23245 ENOG4105BZU Histidine kinase FVA81_23255 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FVA81_23265 ENOG4105D52 delta-aminolevulinic acid dehydratase FVA81_23285 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FVA81_23290 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FVA81_23295 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FVA81_23305 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FVA81_23310 ENOG4107XZX Involved in the transcription termination process (By similarity) FVA81_23315 ENOG4105DXI Major Facilitator superfamily FVA81_23320 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FVA81_23340 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FVA81_23345 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FVA81_23350 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FVA81_23355 ENOG4105WJX transcriptional regulator MERR family FVA81_23390 ENOG4107QPH glycogen) synthase FVA81_23415 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FVA81_23420 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FVA81_23425 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FVA81_23430 ENOG4105CYW agmatinase FVA81_23435 ENOG4108UJD 30S ribosomal protein S9 FVA81_23440 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FVA81_23450 ENOG4105K4P CoA-binding domain protein FVA81_23460 ENOG4105K4P CoA-binding domain protein FVA81_23485 ENOG4108RXX maleylacetoacetate isomerase FVA81_23490 ENOG4105D29 Helix-turn-helix type 11 domain protein FVA81_23505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FVA81_23510 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FVA81_23515 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FVA81_23525 ENOG4108SXK Transporter Drug Metabolite Exporter family FVA81_23540 ENOG4105CPC Aldo Keto reductase FVA81_23550 ENOG4105CT4 transporter FVA81_23555 ENOG4105C6Y Udp-glucose 6-dehydrogenase FVA81_23560 ENOG4105C1B dTDP-glucose 4-6-dehydratase FVA81_23570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FVA81_23595 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FVA81_23600 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FVA81_23605 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FVA81_23610 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FVA81_23620 ENOG4105GKE subunit e FVA81_23625 ENOG4107QIZ NADH dehydrogenase FVA81_23635 ENOG4107R0R NADH dehydrogenase subunit g FVA81_23640 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FVA81_23645 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FVA81_23650 ENOG4105DF2 NADH dehydrogenase subunit j FVA81_23655 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FVA81_23660 ENOG4105D65 subunit l FVA81_23665 ENOG4105C8S subunit m FVA81_23670 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FVA81_23695 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FVA81_23705 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FVA81_23710 ENOG4105C0B DNA polymerase III (alpha subunit) FVA81_23725 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FVA81_23740 ENOG4108UXN response regulator FVA81_23745 ENOG4105BZU Histidine kinase FVA81_23750 ENOG4105W0E 50S ribosomal protein L33 FVA81_23755 ENOG4108ISG Major Facilitator FVA81_23765 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FVA81_23780 ENOG4105C79 DNA protecting protein DprA FVA81_23785 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FVA81_23790 ENOG4105CD3 dihydroorotase FVA81_23795 ENOG4105CXT aspartate transcarbamylase FVA81_23800 ENOG4105CSU acyl-Coa dehydrogenase FVA81_23820 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FVA81_23825 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FVA81_23830 ENOG4107T8T UPF0173 metal-dependent hydrolase FVA81_23835 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FVA81_23840 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FVA81_23860 ENOG4105YCT UPF0386 protein FVA81_23865 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FVA81_23875 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FVA81_23920 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FVA81_23925 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FVA81_23930 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FVA81_23935 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FVA81_23955 ENOG4105C03 ribonuclease FVA81_23960 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FVA81_23980 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FVA81_24090 ENOG4105DFP Integrase FVA81_24105 ENOG4105C3Q Glycosyl transferase, family 2 FVA81_24110 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase FVA81_24115 ENOG4105C2N RNA methyltransferase TrmH family group 3 FVA81_24130 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FVA81_24160 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FVA81_24165 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FVA81_24170 ENOG4108VZM 50s ribosomal protein L10 FVA81_24175 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FVA81_24180 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FVA81_24185 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FVA81_24195 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FVA81_24200 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FVA81_24205 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FVA81_24210 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FVA81_24215 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FVA81_24220 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FVA81_24225 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FVA81_24230 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FVA81_24235 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FVA81_24240 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FVA81_24245 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FVA81_24250 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FVA81_24255 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FVA81_24260 ENOG41083MP 50s ribosomal protein l29 FVA81_24265 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FVA81_24270 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FVA81_24275 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FVA81_24280 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FVA81_24285 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FVA81_24290 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FVA81_24295 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FVA81_24300 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FVA81_24305 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FVA81_24310 ENOG41084HQ 50S ribosomal protein L30 FVA81_24315 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FVA81_24320 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FVA81_24325 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FVA81_24330 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FVA81_24335 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FVA81_24340 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FVA81_24345 ENOG4108ZT0 50S ribosomal protein l17 FVA81_24350 ENOG4105CHP RNA polymerase FVA81_24360 ENOG4105GRZ Ycii-related protein FVA81_24365 ENOG4105NX3 Membrane FVA81_24375 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FVA81_24380 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FVA81_24390 ENOG4105C01 Dihydroxy-acid dehydratase FVA81_24405 ENOG4105FB2 class II Aldolase FVA81_24415 ENOG4105ETT transcriptional Regulator, LysR family FVA81_24445 ENOG4105C0H protease FVA81_24450 ENOG4105D1H recombination factor protein RarA FVA81_24470 ENOG4107RTZ reductase FVA81_24480 ENOG4105K4T epimerase FVA81_24485 ENOG4108TM9 integral membrane protein FVA81_24510 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FVA81_24520 ENOG4105CEV competence damage-inducible protein FVA81_24525 ENOG4105CS1 NAD(P)H quinone oxidoreductase FVA81_24560 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FVA81_24635 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component FVA81_24645 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FVA81_24650 ENOG4105C7B Threonine dehydratase FVA81_24665 ENOG4105BZU Histidine kinase FVA81_24670 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FVA81_24675 ENOG4105DUM transcriptional regulator, lysR family FVA81_24680 ENOG4105CGH 5'-nucleotidase FVA81_24700 ENOG4108YXU transcriptional regulator AsnC family FVA81_24705 ENOG4105DCF alanine dehydrogenase FVA81_24730 ENOG4105KHC sulfurtransferase FVA81_24745 ENOG4105KRQ Addiction module toxin, Txe YoeB family FVA81_24755 ENOG4105CVP deoxyribo-dipyrimidine photolyase FVA81_24785 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FVA81_24795 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FVA81_24805 ENOG4108P7N Exopolysaccharide production negative regulator FVA81_24815 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FVA81_24820 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FVA81_24825 ENOG4105C75 arginyL-tRNA synthetase FVA81_24835 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FVA81_24845 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FVA81_24855 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FVA81_24865 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FVA81_24870 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FVA81_24875 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FVA81_24880 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FVA81_24920 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FVA81_24930 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FVA81_24935 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FVA81_24955 ENOG4105DHZ alpha beta FVA81_24960 ENOG4105C3J Cysteine desulfurase FVA81_24975 ENOG4105JRK feS assembly protein SufD FVA81_24980 ENOG4105C9B Cysteine desulfurase FVA81_24985 ENOG4105VG1 fes assembly suf system protein FVA81_24990 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FVA81_24995 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FVA81_25000 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) FVA81_25005 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FVA81_25010 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FVA81_25015 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FVA81_25055 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FVA81_25060 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FVA81_25065 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FVA81_25090 ENOG41082CG Protein CrcB homolog FVA81_25095 ENOG4105EI2 Pseudouridine synthase FVA81_25100 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FVA81_25150 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FVA81_25155 ENOG41081F0 Precorrin-8x methylmutase FVA81_25160 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase FVA81_25165 ENOG4105DVK Precorrin-2 c20-methyltransferase FVA81_25175 ENOG4105CIA precorrin-4 C(11)-methyltransferase FVA81_25185 ENOG4105DU0 nucleoside hydrolase FVA81_25210 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FVA81_25215 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FVA81_25225 ENOG41067RQ csbd family FVA81_25250 ENOG4105EXC Acyl-transferase FVA81_25260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FVA81_25265 ENOG4105PW4 Sugar fermentation stimulation protein homolog FVA81_25270 ENOG4105KVH Transcriptional regulator FVA81_25280 ENOG4105CHR reductase FVA81_25285 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FVA81_25295 ENOG4105CHM Aminotransferase FVA81_25300 ENOG4105D6E homoserine dehydrogenase FVA81_25310 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FVA81_25340 ENOG4105VEQ Cold shock protein FVA81_25370 ENOG4105CDA abc transporter atp-binding protein FVA81_25375 ENOG4105DRP amino acid AbC transporter FVA81_25380 ENOG4105EZ7 amino acid ABC transporter FVA81_25385 ENOG4107QXX ABC transporter FVA81_25390 ENOG4105C28 cystathionine FVA81_25415 ENOG4105D7W serine acetyltransferase FVA81_25430 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FVA81_25455 ENOG4105K59 histidine triad (HIT) protein FVA81_25480 ENOG4105CE9 30S ribosomal protein S2 FVA81_25485 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FVA81_25490 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FVA81_25495 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FVA81_25500 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FVA81_25510 ENOG4105DZP Membrane-associated zinc metalloprotease FVA81_25515 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FVA81_25520 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FVA81_25525 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FVA81_25530 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FVA81_25535 ENOG4105GYT Protein of unknown function (DUF1009)