locus-tag class description A3858_00055 ENOG4108MYF A3858_00060 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family A3858_00065 ENOG4108WUH Transcriptional regulator, TetR family A3858_00075 ENOG4105E0A ABC, transporter A3858_00080 ENOG4105S6R Iron-hydroxamate transporter permease subunit A3858_00085 ENOG4105J76 Periplasmic binding protein A3858_00090 ENOG4105E0K tonB-dependent siderophore receptor A3858_00110 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component A3858_00120 ENOG4105RD7 BadF BadG BcrA BcrD A3858_00150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3858_00165 ENOG4105CE7 Amidase, hydantoinase carbamoylase family A3858_00185 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA A3858_00210 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) A3858_00230 ENOG4105CEN a g-specific adenine glycosylase A3858_00235 ENOG4105EEF Alkane 1-monooxygenase A3858_00240 ENOG4105CEC DNA methylase N-4 N-6 A3858_00245 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A3858_00270 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) A3858_00290 ENOG4108JQ5 ABC transporter A3858_00295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_00300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3858_00305 ENOG4108J59 Extracellular solute-binding protein, family 5 A3858_00325 ENOG4108IG5 Transcriptional regulator A3858_00330 ENOG4105KCV RNA signal recognition particle 4.5S RNA A3858_00340 ENOG4105K63 Thioredoxin A3858_00350 ENOG4105W49 UPF0434 protein A3858_00360 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A3858_00365 ENOG4105CHM Aminotransferase A3858_00390 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A3858_00420 ENOG4105D3G Pseudouridine synthase A3858_00455 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A3858_00460 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A3858_00475 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A3858_00480 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) A3858_00490 ENOG4108R7K Metal Dependent Phosphohydrolase A3858_00495 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS A3858_00500 ENOG4108UYB regulatoR A3858_00505 ENOG4108ZX6 Electron transport protein SCO1 SenC A3858_00510 ENOG4105TX3 Histidine kinase A3858_00515 ENOG4105I8F Histidine kinase A3858_00525 ENOG4105EHM Aminoglycoside phosphotransferase A3858_00530 ENOG4108S0S Nucleotidyl transferase A3858_00535 ENOG4107RMM double-strand break repair protein Addb A3858_00540 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A3858_00545 ENOG4105K63 Thioredoxin A3858_00555 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) A3858_00560 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) A3858_00565 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A3858_00595 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase A3858_00615 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A3858_00635 ENOG4108UQY Iron-storage protein A3858_00650 ENOG4108Q2J Inner membrane protein YebE A3858_00655 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region A3858_00665 ENOG4108Z2U ureidoglycolate hydrolase A3858_00670 ENOG4105S0E allantoin catabolism protein A3858_00685 ENOG4106FSN Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers A3858_00690 ENOG410669I Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers A3858_00700 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A3858_00705 ENOG4105CEY Amp-dependent synthetase and ligase A3858_00710 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase A3858_00715 ENOG4105DEN Luciferase family A3858_00720 ENOG4105IPI Membrane A3858_00735 ENOG4105BZU Histidine kinase A3858_00740 ENOG4105CFQ glutamine synthetase A3858_00750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A3858_00780 ENOG4107RIQ Sulfate adenylate transferase A3858_00785 ENOG4105C3M thioredoxin reductase A3858_00790 ENOG4105F7P transcriptional regulator AsnC family A3858_00795 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A3858_00805 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) A3858_00820 ENOG4108VYJ response regulator receiver protein A3858_00825 ENOG4105CBS Chea signal transduction histidine kinase A3858_00830 ENOG4108V3W Chemotaxis protein, CheW A3858_00835 ENOG4108V3W Chemotaxis protein, CheW A3858_00840 ENOG4105BZU Histidine kinase A3858_00845 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A3858_00855 ENOG4105CHF Glutathione S-transferase A3858_00860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A3858_00870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A3858_00875 ENOG4105C6K Malic enzyme A3858_00880 ENOG4105KG3 cytidine deaminase A3858_00885 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A3858_00890 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) A3858_00895 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) A3858_00900 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A3858_00930 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_00940 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A3858_00945 ENOG4105C6F GntR Family Transcriptional Regulator A3858_00950 ENOG410617M Transcriptional regulator A3858_00955 ENOG4105CPQ Dehydrogenase A3858_00960 ENOG4107QZW Altronate oxidoreductase A3858_00965 ENOG4105CTX dehydratase A3858_01035 ENOG410903D sensor protein A3858_01040 ENOG4105WH1 Two component transcriptional regulator luxr family A3858_01190 ENOG4105Y2X UPF0335 protein A3858_01215 ENOG4105DIQ Transcriptional regulator A3858_01230 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A3858_01250 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A3858_01265 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) A3858_01270 ENOG4105C3F Signal peptidase i A3858_01280 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A3858_01290 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) A3858_01295 ENOG4105C1G acyl-Coa dehydrogenase A3858_01305 ENOG4105E3W Two component transcriptional regulator (Winged helix family A3858_01310 ENOG4105EB3 Histidine kinase A3858_01320 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A3858_01330 ENOG41080Z8 PHOSPHOCARRIER protein A3858_01340 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A3858_01355 ENOG4105TPV A3858_01360 ENOG4108WBT adenosyltransferase A3858_01370 ENOG4105E1F short-chain dehydrogenase reductase A3858_01380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3858_01410 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A3858_01415 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A3858_01425 ENOG4108VZM 50s ribosomal protein L10 A3858_01430 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A3858_01440 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A3858_01445 ENOG4105DFI Membrane A3858_01460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A3858_01475 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A3858_01515 ENOG41083MP 50s ribosomal protein l29 A3858_01535 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A3858_01575 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A3858_01580 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A3858_01610 ENOG4105C0H protease A3858_01615 ENOG4105D1H recombination factor protein RarA A3858_01625 ENOG4105EI2 Pseudouridine synthase A3858_01635 ENOG4107QXX ABC transporter A3858_01640 ENOG4105EZ7 amino acid ABC transporter A3858_01645 ENOG4105DRP amino acid AbC transporter A3858_01650 ENOG4105CDA abc transporter atp-binding protein A3858_01655 ENOG4105U82 Ferredoxin A3858_01685 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) A3858_01690 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) A3858_01700 ENOG4105RX8 Protein of unknown function (DUF1523) A3858_01705 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A3858_01735 ENOG4105CA9 Pyruvate kinase A3858_01745 ENOG4105F0I Aminotransferase A3858_01750 ENOG4107S8C mandelate racemase muconate lactonizing A3858_01775 ENOG4105KPY Small multidrug resistance protein A3858_01795 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase A3858_01805 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A3858_01835 ENOG4105ETE Transcriptional regulator (LacI family A3858_01840 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A3858_01845 ENOG4105DE4 1-phosphofructokinase A3858_01850 ENOG4105DM4 PTS System A3858_01855 ENOG4105KK4 UPF0060 membrane protein A3858_01860 ENOG4105W1Y Transcriptional regulator A3858_01865 ENOG4105C59 p-type ATPase A3858_01870 ENOG4108UUM single-stranded DNA-binding protein A3858_01875 ENOG4105E4C Lytic transglycosylase catalytic A3858_01880 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A3858_01885 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A3858_01895 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A3858_01900 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A3858_01905 ENOG4108UIV Protein of unknown function (DUF498/DUF598) A3858_01910 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) A3858_01915 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) A3858_01920 ENOG41060IM Heme exporter protein A3858_01930 ENOG4107QX9 Thiol disulfide interChange protein A3858_01935 ENOG4107QM5 aconitate hydratase A3858_01950 ENOG4105C31 Tryptophanyl-tRNA synthetase A3858_01960 ENOG4105CJR Integral membrane protein (MviN A3858_01965 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) A3858_01975 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A3858_01980 ENOG41082D8 UPF0102 protein A3858_01985 ENOG4105D7Z glutathione synthase A3858_01990 ENOG4105C0P Mg chelatase subunit ChlI A3858_02005 ENOG4105XFK Ferrous iron transport protein A A3858_02015 ENOG4108Z9Z response to DNA damage stimulus A3858_02020 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit A3858_02025 ENOG4107RA1 nh(3)-dependent nad( ) synthetase A3858_02030 ENOG4108RIR Molybdenum cofactor biosynthesis protein A3858_02040 ENOG4105D1U peptidase U62 modulator of DNA gyrase A3858_02045 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) A3858_02055 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) A3858_02060 ENOG4107QS1 Cytochrome C Oxidase, Subunit III A3858_02070 ENOG4105D98 threonine synthase A3858_02095 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) A3858_02100 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) A3858_02105 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) A3858_02120 ENOG4107835 probably involved in intracellular septation (By similarity) A3858_02130 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A3858_02140 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A3858_02150 ENOG4105C12 Phosphoribosylglycinamide synthetase A3858_02155 ENOG4105CA9 Pyruvate kinase A3858_02160 ENOG4105CFH Aspartokinase A3858_02165 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A3858_02180 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) A3858_02185 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) A3858_02195 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit A3858_02205 ENOG4105C38 Glycyl-tRNA synthetase beta subunit A3858_02210 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A3858_02225 ENOG4105EEI dihydropteroate synthase A3858_02230 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A3858_02240 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A3858_02245 ENOG4105FKN transcriptional regulator, AsnC family A3858_02250 ENOG4108XM1 transcriptional regulator AsnC family A3858_02260 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase A3858_02275 ENOG4105DRR Transcriptional regulator, GntR family A3858_02290 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A3858_02305 ENOG4105BZ9 Cytochrome C oxidase, subunit I A3858_02310 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) A3858_02325 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_02335 ENOG4105F38 ABC transporter, permease A3858_02340 ENOG4105D38 putrescine abc transporter A3858_02355 ENOG4105HFZ Membrane A3858_02385 ENOG4105F0V Cell wall hydrolase A3858_02390 ENOG4105D8X mechanosensitive ion channel A3858_02395 ENOG4107QUY Guanine deaminase A3858_02400 ENOG4105CJW magnesium transporter A3858_02405 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase A3858_02450 ENOG4105CDV Ompa motb domain protein A3858_02475 ENOG4105E4C Lytic transglycosylase catalytic A3858_02500 ENOG4105ETT transcriptional Regulator, LysR family A3858_02530 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) A3858_02535 ENOG4108RPX mosc domain containing protein A3858_02550 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A3858_02555 ENOG4105VKD bioY protein A3858_02565 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A3858_02570 ENOG4105HF0 Membrane A3858_02575 ENOG4105CDU Replicative dna helicase A3858_02580 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A3858_02585 ENOG4105EKE dihydroorotase A3858_02610 ENOG4107XAN XdhC and CoxI family A3858_02620 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A3858_02630 ENOG4105DP0 ferredoxin-NADP reductase A3858_02640 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) A3858_02645 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A3858_02655 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3858_02660 ENOG4108XM1 transcriptional regulator AsnC family A3858_02670 ENOG4105CP7 Triose-phosphate isomerase A3858_02680 ENOG4105VG1 fes assembly suf system protein A3858_02700 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A3858_02765 ENOG4105CXB phosphoribosylaminoimidazole synthetase A3858_02770 ENOG4108V3E phosphoribosylglycinamide formyltransferase A3858_02775 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) A3858_02785 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) A3858_02795 ENOG4105DC7 peptidase M24 A3858_02820 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A3858_02830 ENOG4107QP3 malate synthase g A3858_02840 ENOG4105CD8 aminopeptidase N A3858_02850 ENOG4105CIH Imidazole acetol-phosphate transaminase A3858_02860 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A3858_02875 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A3858_02905 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A3858_02910 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A3858_02915 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A3858_02920 ENOG4105CVM Molybdenum cofactor synthesis domain protein A3858_02925 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3858_02930 ENOG4105DK0 Indole-3-glycerol phosphate synthase A3858_02935 ENOG4108I0Q anthranilate phosphoribosyltransferase A3858_02940 ENOG4105DDQ anthranilate synthase A3858_02950 ENOG4105CRQ synthase (Component I) A3858_02970 ENOG4105C8Y Acetylornithine aminotransferase A3858_02975 ENOG4105DBV ornithine carbamoyltransferase A3858_02985 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A3858_02995 ENOG4105CQ7 ATP-dependent helicase A3858_03005 ENOG4105DJT lAO AO transport system ATPase A3858_03040 ENOG4105VBA Cytochrome A3858_03065 ENOG410642W LysR family Transcriptional regulator A3858_03080 ENOG4105BZU Histidine kinase A3858_03325 ENOG4105Y2X UPF0335 protein A3858_03360 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A3858_03390 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A3858_03400 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A3858_03405 ENOG4105C4R Atp-dependent dna helicase A3858_03410 ENOG4105DKK Benzoate A3858_03430 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A3858_03445 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A3858_03465 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A3858_03485 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A3858_03490 ENOG4105DFU Cell wall formation (By similarity) A3858_03500 ENOG4105D4A Cell wall formation (By similarity) A3858_03510 ENOG4108UFP Essential cell division protein (By similarity) A3858_03515 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A3858_03520 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A3858_03525 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A3858_03530 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A3858_03545 ENOG4105CQB FAD linked oxidase domain protein A3858_03555 ENOG4108Q52 Methyltransferase cognate corrinoid protein A3858_03575 ENOG4107QPR SAICAR synthetase A3858_03580 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A3858_03585 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I A3858_03590 ENOG4105CQZ Histidine kinase A3858_03610 ENOG4107QIV Cytochrome c biogenesis protein A3858_03630 ENOG4105C9Q fumarate hydratase class II A3858_03650 ENOG4107RUE extracellular solute-binding protein family 1 A3858_03655 ENOG4105C9B Cysteine desulfurase A3858_03660 ENOG4105CVP deoxyribo-dipyrimidine photolyase A3858_03665 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase A3858_03675 ENOG41087AY ADP-Ribose pyrophosphatase A3858_03685 ENOG4105EGS Mechanosensitive ion channel A3858_03690 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A3858_03695 ENOG4105CKK Glycosyl transferase, family 2 A3858_03720 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A3858_03725 ENOG4105D38 putrescine abc transporter A3858_03740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_03745 ENOG4105CHR reductase A3858_03765 ENOG4105EW9 transcriptional regulator AsnC family A3858_03785 ENOG4105ECY inositol monophosphatase A3858_03790 ENOG4105CJ3 phosphate transporter A3858_03795 ENOG4105DZ2 Transcriptional regulator A3858_03800 ENOG4105SYT Methylenetetrahydrofolate reductase A3858_03805 ENOG4107ZYJ bioY protein A3858_03810 ENOG4107YZB Cobalt transport protein A3858_03815 ENOG4108JJB ABC transporter A3858_03825 ENOG4105C79 DNA protecting protein DprA A3858_03835 ENOG4108IJ7 Glycine betaine A3858_03850 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) A3858_03855 ENOG4105C26 Dehydrogenase A3858_03860 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) A3858_03870 ENOG4105CFF transcriptional regulator A3858_03885 ENOG4107QX3 carboxylase A3858_03905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A3858_03920 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A3858_03925 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) A3858_03930 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A3858_03935 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A3858_03940 ENOG4105CHU acetyl-coa acetyltransferase A3858_03950 ENOG4105CSU acyl-Coa dehydrogenase A3858_03975 ENOG4107R73 Mate efflux family protein A3858_03985 ENOG4108VCT Sulfite exporter TauE/SafE A3858_03990 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) A3858_04000 ENOG4105UIB (ABC) transporter A3858_04005 ENOG4108JQ9 ABC transporter A3858_04010 ENOG4105DIH basic membrane A3858_04020 ENOG41072GX Peptidase M22 Glycoprotease A3858_04025 ENOG41083MR nifu domain-containing protein A3858_04035 ENOG4105CM2 brancheD-chain amino acid aminotransferase A3858_04040 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A3858_04045 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein A3858_04060 ENOG4105C83 adenylosuccinate lyase A3858_04065 ENOG4105UCG Domain of unknown function (DUF333) A3858_04070 ENOG4105BZS acriflavin resistance protein A3858_04075 ENOG4105ENT Efflux transporter rnd family, mfp subunit A3858_04090 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A3858_04100 ENOG4105BZU Histidine kinase A3858_04115 ENOG4108UN4 phage SPO1 DNA polymerase-related protein A3858_04135 ENOG4105CW7 secretion protein, HlyD family A3858_04140 ENOG4105C0R drug resistance transporter emrb qaca subfamily A3858_04155 ENOG4105C2N RNA methyltransferase TrmH family group 3 A3858_04160 ENOG4105K4P CoA-binding domain protein A3858_04165 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase A3858_04170 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A3858_04175 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase A3858_04185 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A3858_04190 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A3858_04210 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) A3858_04225 ENOG4105BZ1 (ABC) transporter A3858_04230 ENOG4105CEY Amp-dependent synthetase and ligase A3858_04235 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) A3858_04245 ENOG4105C8V SAICAR synthetase A3858_04250 ENOG4105W39 Membrane A3858_04290 ENOG4105FE9 pseudouridine synthase A3858_04295 ENOG4108Z6B deaminase A3858_04300 ENOG4107T8T UPF0173 metal-dependent hydrolase A3858_04315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A3858_04325 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase A3858_04335 ENOG4105DZS Phenylacetate-CoA ligase A3858_04340 ENOG4108IV0 ABC, transporter A3858_04355 ENOG4105C32 Amino acid ABC transporter (Permease) A3858_04360 ENOG4105C0Z ABC transporter A3858_04370 ENOG4108IQE Amp-dependent synthetase and ligase A3858_04380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3858_04400 ENOG4105CIH Imidazole acetol-phosphate transaminase A3858_04420 ENOG4108NH8 Cation transport protein A3858_04450 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A3858_04470 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A3858_04480 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A3858_04495 ENOG4108ZZ3 UPF0260 protein A3858_04500 ENOG4105DTN riboflavin biosynthesis protein ribF A3858_04505 ENOG4108Z7G MaoC domain protein dehydratase A3858_04515 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase A3858_04525 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A3858_04530 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A3858_04545 ENOG4105CV8 reductase A3858_04555 ENOG4105MWK D-amino acid dehydrogenase, small subunit A3858_04565 ENOG4105C26 Dehydrogenase A3858_04570 ENOG4105C5F glutamine synthetase A3858_04575 ENOG4105CH5 extracellular solute-binding protein, family 7 A3858_04580 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_04600 ENOG4105CNI cell division protein FtsW A3858_04605 ENOG4105CJN penicillin-binding protein A3858_04615 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A3858_04630 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) A3858_04645 ENOG4105C4K Nad synthetase A3858_04655 ENOG4105CS1 NAD(P)H quinone oxidoreductase A3858_04685 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) A3858_04690 ENOG4105CHM Aminotransferase A3858_04705 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A3858_04710 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) A3858_04715 ENOG4105VEQ Cold shock protein A3858_04810 ENOG4105FDP GntR family transcriptional regulator A3858_04815 ENOG4105CHR reductase A3858_04820 ENOG4107W7X Aldolase A3858_04830 ENOG4105C2J ABC transporter A3858_04835 ENOG4105CNN ABC, transporter A3858_04840 ENOG4105F5R ABC transporter A3858_04845 ENOG4105D7K pfkb domain protein A3858_04850 ENOG4105CHR reductase A3858_04870 ENOG4105CNG UPF0061 protein A3858_04875 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A3858_04880 ENOG4105CPQ Dehydrogenase A3858_04885 ENOG4107E6A Cytochrome p-450 A3858_04905 ENOG4108VX5 3-methyladenine DNA glycosylase A3858_04980 ENOG4105CA0 peroxidase A3858_04990 ENOG4107RUE extracellular solute-binding protein family 1 A3858_04995 ENOG4105D38 putrescine abc transporter A3858_05000 ENOG4105F38 ABC transporter, permease A3858_05005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_05015 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) A3858_05025 ENOG4105EHG Permease protein A3858_05030 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) A3858_05040 ENOG4105BZU Histidine kinase A3858_05055 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_05070 ENOG4107T0X DNA ligase A3858_05130 ENOG4108Z4U Ferredoxin A3858_05135 ENOG4108VJ1 Transcriptional regulator (CarD family A3858_05140 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) A3858_05145 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) A3858_05160 ENOG4105MPN Membrane A3858_05165 ENOG4108IQK o-acetylhomoserine A3858_05175 ENOG4108VYJ response regulator receiver protein A3858_05180 ENOG4105BZU Histidine kinase A3858_05185 ENOG4108V3W Chemotaxis protein, CheW A3858_05190 ENOG4105CBS Chea signal transduction histidine kinase A3858_05195 ENOG4108VYJ response regulator receiver protein A3858_05205 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) A3858_05220 ENOG4105C8Q Methyl-accepting chemotaxis A3858_05225 ENOG4108VYJ response regulator receiver protein A3858_05235 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) A3858_05245 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) A3858_05255 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) A3858_05270 ENOG4105EMU Dehydrogenase A3858_05275 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase A3858_05295 ENOG4105DHJ ABC, transporter A3858_05305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A3858_05320 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A3858_05325 ENOG4105HHA aminodeoxychorismate lyase A3858_05415 ENOG4105D7W serine acetyltransferase A3858_05420 ENOG4105C7S Dehydrogenase A3858_05425 ENOG4105CPP Dehydrogenase, E1 component A3858_05430 ENOG4108JYK Dehydrogenase A3858_05435 ENOG4106ABQ septum formation initiator A3858_05440 ENOG4105EIE fructose-bisphosphate aldolase A3858_05445 ENOG4105BZA Phosphoglycerate kinase A3858_05450 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A3858_05455 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) A3858_05460 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A3858_05465 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) A3858_05485 ENOG4105DFI Membrane A3858_05490 ENOG41090R7 Ferric uptake A3858_05495 ENOG4107RTZ reductase A3858_05525 ENOG4107XWS modD protein A3858_05535 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A3858_05540 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A3858_05550 ENOG4105C1G acyl-Coa dehydrogenase A3858_05555 ENOG4105EIF outer membrane protein W A3858_05560 ENOG4107QX3 carboxylase A3858_05570 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A3858_05575 ENOG4108IPT Naphthoate synthase A3858_05580 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A3858_05595 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_05600 ENOG4105GKE subunit e A3858_05610 ENOG4107QIZ NADH dehydrogenase A3858_05620 ENOG4107R0R NADH dehydrogenase subunit g A3858_05630 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) A3858_05640 ENOG4108048 decarboxylase A3858_05645 ENOG4105DF2 NADH dehydrogenase subunit j A3858_05655 ENOG4105D65 subunit l A3858_05660 ENOG4105C8S subunit m A3858_05665 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_05670 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase A3858_05685 ENOG4105C1J atp-dependent rna helicase A3858_05690 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) A3858_05700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_05705 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A3858_05715 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A3858_05725 ENOG4108K5P (LipO)protein A3858_05735 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) A3858_05795 ENOG4105BZ1 (ABC) transporter A3858_05830 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A3858_05840 ENOG4105FAW cDP-glucose 4,6-dehydratase A3858_05845 ENOG4108Z0Z intracellular protease Pfpi family A3858_05855 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A3858_05870 ENOG4108QBQ Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity) A3858_05875 ENOG4107QPD alcohol dehydrogenase A3858_05880 ENOG4105XUA cytochrome c A3858_05885 ENOG4105DZG Dehydrogenase A3858_05890 ENOG4108U4V Cytochrome c protein A3858_05895 ENOG4108Q1J Extracellular solute-binding protein, family 3 A3858_05925 ENOG4105CJ1 ABC, transporter A3858_05960 ENOG4105BZU Histidine kinase A3858_05975 ENOG4105D7T ABC transporter A3858_05985 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A3858_05990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3858_05995 ENOG4108UTW Plays a role in the regulation of phosphate uptake A3858_06000 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A3858_06005 ENOG4105E2Z phosphate ABC transporter (Permease A3858_06010 ENOG4105C8U phosphate abc transporter A3858_06035 ENOG4107QUT magnesium and cobalt transport protein CorA A3858_06040 ENOG4105DHP deoxycytidine triphosphate deaminase A3858_06050 ENOG4105WJX transcriptional regulator MERR family A3858_06060 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A3858_06065 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) A3858_06085 ENOG4105E0X reductase A3858_06095 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A3858_06105 ENOG4105EFQ Two component transcriptional regulator (Winged helix family A3858_06110 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A3858_06115 ENOG4105CB5 ATP-dependent DNA helicase recG A3858_06125 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A3858_06130 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) A3858_06135 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) A3858_06140 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3858_06145 ENOG4105P0T Usg family A3858_06155 ENOG4105DA4 cytochrome c-type biogenesis protein A3858_06160 ENOG4105KWW Biogenesis protein A3858_06165 ENOG4105CGU Enoyl-CoA hydratase A3858_06170 ENOG4108ZP8 Acetolactate synthase small subunit A3858_06175 ENOG4105C7K acetolactate synthase A3858_06185 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate A3858_06205 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) A3858_06215 ENOG4108UHU Aldolase A3858_06220 ENOG4105C01 Dihydroxy-acid dehydratase A3858_06260 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters A3858_06265 ENOG4105MSY salicylate hydroxylase A3858_06280 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A3858_06290 ENOG4107U9T Pfam:Ribonuclease_BN A3858_06300 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A3858_06315 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component A3858_06325 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_06330 ENOG4108IJ9 (ABC) transporter A3858_06335 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A3858_06350 ENOG4105DZG Dehydrogenase A3858_06385 ENOG4105DQE DNA ligase A3858_06400 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A3858_06415 ENOG4106FI7 cytochrome c-type biogenesis protein A3858_06420 ENOG4105DDR sarcosine oxidase (Beta subunit) A3858_06435 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A3858_06445 ENOG4105EXC Acyl-transferase A3858_06450 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A3858_06465 ENOG4108JJ7 ABC transporter A3858_06490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_06495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3858_06505 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A3858_06510 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A3858_06515 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A3858_06520 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A3858_06525 ENOG4105KNE Phosphatidate cytidylyltransferase A3858_06530 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) A3858_06535 ENOG4105DZP Membrane-associated zinc metalloprotease A3858_06540 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane A3858_06555 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A3858_06560 ENOG4105GYT Protein of unknown function (DUF1009) A3858_06565 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A3858_06570 ENOG4105C5H ABC transporter A3858_06595 ENOG4105C8N cysteinyl-tRNA synthetase A3858_06615 ENOG4105DXI Major Facilitator superfamily A3858_06620 ENOG4105D03 DNA-3-methyladenine glycosylase II A3858_06645 ENOG4105CAU Arsenical resistance protein, ArsH A3858_06655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A3858_06665 ENOG4107QP8 phosphohexose isomerase A3858_06670 ENOG4105M4H endoribonuclease L-psp A3858_06675 ENOG4105KHC sulfurtransferase A3858_06680 ENOG41066VF YeeE YedE family protein A3858_06685 ENOG4105DKB L-sorbosone dehydrogenase A3858_06690 ENOG4105N7H Cytochrome A3858_06710 ENOG4108I69 Glycosyl transferases group 1 A3858_06730 ENOG4105DFP Integrase A3858_06835 ENOG4105DAE Methylenetetrahydrofolate reductase A3858_06845 ENOG4105C9X ppx gppa phosphatase A3858_06850 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) A3858_06855 ENOG4105EAQ (twin-arginine translocation) pathway signal A3858_06865 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) A3858_06870 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A3858_06910 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding A3858_06915 ENOG41085AF Cytochrome A3858_06920 ENOG4108UGV hypoxanthine phosphoribosyltransferase A3858_06925 ENOG4108Z1B Cyclase dehydrase A3858_06935 ENOG4105DJV ribulose-phosphate 3-epimerase A3858_06950 ENOG4105CE9 30S ribosomal protein S2 A3858_06960 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) A3858_06970 ENOG4105E43 Extracellular solute-binding protein, family 5 A3858_06990 ENOG4108IG5 Transcriptional regulator A3858_06995 ENOG4107ZXU DSBA oxidoreductase A3858_07000 ENOG4105C2C drug resistance transporter, Bcr CflA A3858_07015 ENOG4105D52 delta-aminolevulinic acid dehydratase A3858_07025 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A3858_07035 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A3858_07050 ENOG4105C1A potassium transporter peripheral membrane A3858_07055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A3858_07060 ENOG4105ES5 Histidine kinase A3858_07070 ENOG4105CUX Signal transduction histidine kinase A3858_07075 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A3858_07080 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) A3858_07095 ENOG4105CEV competence damage-inducible protein A3858_07100 ENOG4105CBX hi0933 family A3858_07140 ENOG41081F0 Precorrin-8x methylmutase A3858_07155 ENOG4105QUC reductase A3858_07170 ENOG4105CIA precorrin-4 C(11)-methyltransferase A3858_07175 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A3858_07185 ENOG4105D49 3-dehydroquinate synthase A3858_07190 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A3858_07200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3858_07205 ENOG4108JU6 CBS domain protein A3858_07220 ENOG4105F5V trimethylamine methyltransferase A3858_07235 ENOG4105DHJ ABC, transporter A3858_07240 ENOG4105CY3 ABC transporter, permease A3858_07260 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A3858_07265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A3858_07270 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A3858_07275 ENOG4105BZS acriflavin resistance protein A3858_07305 ENOG4108MFQ Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A3858_07310 ENOG4105D1F ATP-binding protein A3858_07320 ENOG4108ZFP monooxygenase component MmoB DmpM A3858_07330 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein A3858_07360 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_07365 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A3858_07375 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_07380 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component A3858_07385 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component A3858_07390 ENOG4105EPJ extracellular solute-binding protein family 1 A3858_07400 ENOG4105CHC glucokinase (EC 2.7.1.2) A3858_07425 ENOG4105BZU Histidine kinase A3858_07440 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 A3858_07450 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) A3858_07460 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) A3858_07465 ENOG4105KPV Transcriptional regulator A3858_07490 ENOG4105C5H ABC transporter A3858_07495 ENOG41081FY multiple antibiotic resistance (MarC)-related A3858_07500 ENOG4108WIW Aspartyl protease A3858_07510 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A3858_07515 ENOG4108K5H permease YjgP YjgQ family protein A3858_07530 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) A3858_07535 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) A3858_07540 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A3858_07550 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A3858_07555 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A3858_07565 ENOG4105CYW agmatinase A3858_07570 ENOG4105CH2 amidohydrolase A3858_07575 ENOG4105DXN mazG family A3858_07590 ENOG4105BZU Histidine kinase A3858_07600 ENOG4105C28 cystathionine A3858_07605 ENOG4108Z0R Transferase A3858_07610 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) A3858_07615 ENOG4105DSJ YicC domain protein A3858_07625 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase A3858_07630 ENOG4105ECQ AraC Family Transcriptional Regulator A3858_07635 ENOG4105CP9 extracellular ligand-binding receptor A3858_07640 ENOG4105C0Z ABC transporter A3858_07645 ENOG4108IV0 ABC, transporter A3858_07650 ENOG4105C32 Amino acid ABC transporter (Permease) A3858_07675 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) A3858_07680 ENOG4105CZE histidine utilization repressor A3858_07690 ENOG4105CI2 imidazolone-5-propionate hydrolase A3858_07695 ENOG4105C84 Histidine ammonia-lyase A3858_07700 ENOG4105CGP Urocanate hydratase A3858_07705 ENOG4105DCG PHP domain protein A3858_07710 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) A3858_07725 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) A3858_07730 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) A3858_07745 ENOG4105C75 arginyL-tRNA synthetase A3858_07765 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A3858_07770 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A3858_07780 ENOG4105DND Transcriptional regulator A3858_07785 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii A3858_07810 ENOG4105CV1 Transketolase (EC 2.2.1.1) A3858_07820 ENOG4105CKW Inner membrane protein yedI A3858_07825 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A3858_07845 ENOG4105C26 Dehydrogenase A3858_07860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A3858_07870 ENOG4107QN2 dihydrolipoyl dehydrogenase A3858_07880 ENOG4105D2S major facilitator superfamily A3858_07885 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) A3858_07895 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A3858_07900 ENOG4105E4C Lytic transglycosylase catalytic A3858_07915 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A3858_07925 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase A3858_07930 ENOG4105CHM Aminotransferase A3858_07940 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) A3858_07950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A3858_07980 ENOG4105EUB pirin domain protein A3858_08015 ENOG4107TII Recombinase A3858_08025 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A3858_08060 ENOG4105CSR polyphosphate kinase 2 A3858_08070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_08075 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component A3858_08080 ENOG4105F38 ABC transporter, permease A3858_08085 ENOG4105CIH Imidazole acetol-phosphate transaminase A3858_08120 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) A3858_08135 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A3858_08140 ENOG4105CYC Transferase A3858_08155 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_08165 ENOG4105D7B Flagellar biosynthesis protein flha A3858_08220 ENOG4105MQ3 flagellar protein FliS A3858_08230 ENOG4105CBS Chea signal transduction histidine kinase A3858_08235 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A3858_08240 ENOG4105C8Q Methyl-accepting chemotaxis A3858_08245 ENOG4107SKI cobyrinic Acid a,c-diamide synthase A3858_08250 ENOG4108V3W Chemotaxis protein, CheW A3858_08255 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A3858_08260 ENOG4105BZU Histidine kinase A3858_08265 ENOG4105CBS Chea signal transduction histidine kinase A3858_08275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A3858_08280 ENOG4105VQ0 flagellar hook-basal body complex protein fliE A3858_08285 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) A3858_08290 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A3858_08300 ENOG4108JIR Flagellum-specific ATP synthase A3858_08320 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A3858_08325 ENOG4105DD5 Flagellar motor switch protein A3858_08335 ENOG4105CN7 Flagellar biosynthetic protein FliP A3858_08340 ENOG4105VS8 Flagellar biosynthetic protein fliq A3858_08345 ENOG4105D19 Role in flagellar biosynthesis (By similarity) A3858_08350 ENOG4105D00 flagellar biosynthetic protein flhB A3858_08365 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_08370 ENOG4105I03 Flagellin A3858_08375 ENOG4107VE5 flagellar hook-associated protein A3858_08380 ENOG4108JUA Transcriptional regulator A3858_08395 ENOG4105E1Q flagellar hook-associated protein A3858_08405 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) A3858_08410 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) A3858_08415 ENOG4105CGA flagellar basal-body rod protein FlgG A3858_08420 ENOG4105KTQ flagellar basal-body rod protein A3858_08425 ENOG4105BZE flagellar hook protein, FlgE A3858_08430 ENOG4105W00 Flagellar hook capping protein A3858_08435 ENOG4108ZC9 flagellar basal-body rod protein flgc A3858_08440 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) A3858_08450 ENOG4105BZU Histidine kinase A3858_08465 ENOG4108Z9Z response to DNA damage stimulus A3858_08470 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 A3858_08475 ENOG4105DKT Transcriptional regulator A3858_08495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_08500 ENOG4105CHR reductase A3858_08505 ENOG4105DEI Mannitol dehydrogenase A3858_08515 ENOG4105CH5 extracellular solute-binding protein, family 7 A3858_08520 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_08530 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A3858_08535 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_08540 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_08545 ENOG4105GKE subunit e A3858_08550 ENOG4107QIZ NADH dehydrogenase A3858_08555 ENOG4108IEH NADH dehydrogenase subunit g A3858_08560 ENOG4107QW0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) A3858_08565 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_08570 ENOG4107UFS subunit j A3858_08575 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_08580 ENOG4105D65 subunit l A3858_08585 ENOG4105C8S subunit m A3858_08590 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A3858_08595 ENOG4105DZQ phospholipase D Transphosphatidylase A3858_08615 ENOG4105BZ9 Cytochrome C oxidase, subunit I A3858_08620 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) A3858_08625 ENOG410841Q phosphoesterase PA-phosphatase related protein A3858_08655 ENOG4105DJ9 glucan biosynthesis protein A3858_08665 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) A3858_08680 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A3858_08685 ENOG4108UMI ABC transporter, permease A3858_08690 ENOG4105D01 (LipO)protein A3858_08695 ENOG4105DFD Na H antiporter A3858_08750 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) A3858_08760 ENOG4108YZA Nitrogen regulatory protein pii A3858_08765 ENOG4105C5F glutamine synthetase A3858_08770 ENOG4105RAK Histidine kinase A3858_08780 ENOG4105EB3 Histidine kinase A3858_08835 ENOG4105C1B dTDP-glucose 4-6-dehydratase A3858_08855 ENOG4105Y2X UPF0335 protein A3858_08880 ENOG4105BZU Histidine kinase A3858_08890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3858_08895 ENOG4105CFF transcriptional regulator A3858_08905 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr A3858_08910 ENOG4105C5I Dehydrogenase A3858_08915 ENOG4105C01 Dihydroxy-acid dehydratase A3858_08920 ENOG4105CQB FAD linked oxidase domain protein A3858_08930 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component A3858_08935 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A3858_08945 ENOG4105CD3 dihydroorotase A3858_08950 ENOG4105CE7 Amidase, hydantoinase carbamoylase family A3858_08955 ENOG4108R86 Transcriptional regulator A3858_08960 ENOG4108R86 Transcriptional regulator A3858_08965 ENOG4107SJI Dehydrogenase A3858_08975 ENOG4105BZ8 glutamate synthase A3858_08985 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A3858_08990 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) A3858_09010 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A3858_09030 ENOG4105CXZ ABC transporter, permease A3858_09035 ENOG4108VGW abc transporter atp-binding protein A3858_09040 ENOG4105K4I Scp-like extracellular A3858_09135 ENOG4105C8Q Methyl-accepting chemotaxis A3858_09205 ENOG4105UYK outer membrane protein a A3858_09210 ENOG4105E14 MotA TolQ exbB proton channel A3858_09215 ENOG4105C8Q Methyl-accepting chemotaxis A3858_09225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3858_09230 ENOG4105MWK D-amino acid dehydrogenase, small subunit A3858_09245 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A3858_09250 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) A3858_09265 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein A3858_09270 ENOG4108Z86 Glutamine amidotransferase A3858_09275 ENOG4105C5R Aminotransferase A3858_09290 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A3858_09310 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) A3858_09315 ENOG4105CJP fad dependent oxidoreductase A3858_09320 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A3858_09330 ENOG4107R94 photosynthetic reaction center, M subunit A3858_09335 ENOG4105VGZ photosynthetic reaction center L subunit A3858_09340 ENOG41068GY Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity) A3858_09345 ENOG4105X2X Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity) A3858_09350 ENOG4106BVK Required for bacteriochlorophyll biosynthesis. Directly involved in the assembly of both the B875 and B800-850 pigment- protein complexes A3858_09355 ENOG4105ETK chlorophyllide reductase subunit Z A3858_09360 ENOG41060GA Chlorophyllide reductase subunit Y A3858_09365 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) A3858_09375 ENOG4107EPK O-methyltransferase, family 2 A3858_09380 ENOG4105CTB Polyprenyl synthetase A3858_09385 ENOG4107VFM Dehydrogenase A3858_09390 ENOG4108PZJ hydroxyneurosporene synthase A3858_09395 ENOG4105KAV tspo and mbr like protein A3858_09400 ENOG4105FE1 phytoene synthase A3858_09405 ENOG4105EWK phytoene A3858_09410 ENOG4108ZIP spheroidene monooxygenase A3858_09415 ENOG4105EET magnesium chelatase A3858_09420 ENOG4107SV1 subunit D A3858_09435 ENOG4107QZT geranylgeranyl reductase A3858_09440 ENOG4105SS7 PucC protein A3858_09445 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase A3858_09450 ENOG4105I29 Bacteriochlorophyll 4-vinyl reductase A3858_09455 ENOG4105EPH radical SAM domain protein A3858_09460 ENOG4105D4D transcriptional regulator A3858_09465 ENOG41062FI Regulatory protein, PpaA A3858_09470 ENOG4108VJI 2-vinyl bacteriochlorophyllide hydratase A3858_09475 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) A3858_09480 ENOG4105EVY Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) A3858_09485 ENOG4105CTK cobaltochelatase, cobn subunit A3858_09495 ENOG4108MIC Mg-protoporphyrin IX methyl transferase A3858_09500 ENOG4105XCI PucC protein A3858_09505 ENOG4108S36 Photosynthetic reaction center A3858_09515 ENOG410844H A3858_09525 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) A3858_09530 ENOG4108TF2 Photosynthetic complex assembly protein 2 A3858_09535 ENOG4105KNK cytochrome C A3858_09540 ENOG4108IV0 ABC, transporter A3858_09545 ENOG4105C0Z ABC transporter A3858_09550 ENOG4105CNN ABC, transporter A3858_09555 ENOG4105C32 Amino acid ABC transporter (Permease) A3858_09565 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) A3858_09570 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) A3858_09575 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) A3858_09585 ENOG4105CQM Urea amidohydrolase subunit alpha A3858_09610 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) A3858_09625 ENOG4106FSN Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers A3858_09630 ENOG410669I Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers A3858_09635 ENOG4105XCI PucC protein A3858_09640 ENOG4105WH1 Two component transcriptional regulator luxr family A3858_09645 ENOG4105D4P Coproporphyrinogen iii oxidase A3858_09670 ENOG4105GMT ATPase associated with various cellular activities aaa_5 A3858_09680 ENOG4108VKQ nitriC oxide reductase A3858_09705 ENOG4105KDM Diguanylate cyclase with gaf sensor A3858_09720 ENOG4107QZ7 Cellulose synthase catalytic subunit A3858_09730 ENOG4105BZU Histidine kinase A3858_09740 ENOG4107TE5 Lipid kinase A3858_09745 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) A3858_09755 ENOG4105DZC cytosine deaminase A3858_09765 ENOG41083U2 ABC transporter, permease A3858_09770 ENOG4108JQ9 ABC transporter A3858_09795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_09810 ENOG4107Z7P Ferredoxin A3858_09815 ENOG4105C0B DNA polymerase III (alpha subunit) A3858_09830 ENOG4105EPW hflc protein A3858_09835 ENOG4107QJR hflk protein A3858_09845 ENOG4105E66 phosphoriboisomerase A A3858_09850 ENOG4105EJQ L-serine dehydratase A3858_09855 ENOG4108SXK Transporter Drug Metabolite Exporter family A3858_09875 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A3858_09880 ENOG4107EJC Preprotein translocase subunit SecG A3858_09885 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A3858_09900 ENOG4108JEH abc transporter atp-binding protein A3858_09905 ENOG4105E89 ABC transporter A3858_09910 ENOG4105DSP amino acid AbC transporter A3858_09915 ENOG4105DMR ABC, transporter A3858_09920 ENOG4105CFQ glutamine synthetase A3858_09930 ENOG4105CFQ glutamine synthetase A3858_09935 ENOG4105CJP fad dependent oxidoreductase A3858_09955 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class A3858_09970 ENOG4105C22 threonyL-tRNA synthetase A3858_09995 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) A3858_10000 ENOG4108UYE Lactoylglutathione lyase A3858_10005 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A3858_10020 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_10025 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A3858_10060 ENOG4105D6E homoserine dehydrogenase A3858_10070 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A3858_10080 ENOG4105BZU Histidine kinase A3858_10085 ENOG4105C5I Dehydrogenase A3858_10100 ENOG4105BZU Histidine kinase A3858_10110 ENOG4108MAJ Membrane A3858_10115 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A3858_10125 ENOG4105BZU Histidine kinase A3858_10175 ENOG4105CPC Aldo Keto reductase A3858_10185 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A3858_10215 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) A3858_10220 ENOG4105C9B Cysteine desulfurase A3858_10235 ENOG4105JRK feS assembly protein SufD A3858_10240 ENOG4105C3K feS assembly ATPase SufC A3858_10255 ENOG4105C3J Cysteine desulfurase A3858_10265 ENOG4105DHZ alpha beta A3858_10285 ENOG4105CI3 gtp-binding protein typa A3858_10300 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A3858_10320 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A3858_10325 ENOG4105E98 transcriptional regulator DeoR family A3858_10350 ENOG4105ENT Efflux transporter rnd family, mfp subunit A3858_10360 ENOG4106RZ4 Peptidase U32 A3858_10365 ENOG4105CFP Peptidase U32 A3858_10375 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) A3858_10380 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase A3858_10385 ENOG4105D5U fad dependent oxidoreductase A3858_10405 ENOG4107RZC phospholipase d A3858_10410 ENOG41085AF Cytochrome A3858_10420 ENOG4107W7X Aldolase A3858_10430 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) A3858_10440 ENOG4105DEI Mannitol dehydrogenase A3858_10445 ENOG4105CHR reductase A3858_10455 ENOG4105M5J Cupin 2, conserved barrel domain protein A3858_10460 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_10470 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A3858_10480 ENOG4105DRR Transcriptional regulator, GntR family A3858_10500 ENOG4105DPX Hydrogenase, large subunit A3858_10505 ENOG4105C8H hydrogenase maturation protein Hypf A3858_10515 ENOG4105DPX Hydrogenase, large subunit A3858_10530 ENOG4108USZ hydrogenase A3858_10535 ENOG4105X9Y Hydrogenase assembly chaperone hypC hupF A3858_10540 ENOG4105YYZ Hydrogenase expression formation protein A3858_10545 ENOG4108UT5 Hydrogenase expression A3858_10550 ENOG410631X Hydrogenase expression formation protein A3858_10555 ENOG4108ZBK Inherit from NOG: hydrogenase expression formation protein HupK A3858_10560 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) A3858_10565 ENOG4107RSS Hydrogenase accessory protein HypB A3858_10570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A3858_10575 ENOG41082MF Hydrogenase assembly chaperone hypC hupF A3858_10580 ENOG4105CQS hydrogenase expression formation protein HypD A3858_10585 ENOG4105C45 hydrogenase expression formation protein (HypE) A3858_10595 ENOG4105WH1 Two component transcriptional regulator luxr family A3858_10600 ENOG4105BZU Histidine kinase A3858_10610 ENOG4108IAJ Nad-dependent epimerase dehydratase A3858_10635 ENOG4108IAJ Nad-dependent epimerase dehydratase A3858_10645 ENOG4105CPQ Dehydrogenase A3858_10650 ENOG4105CK5 oxidoreductase A3858_10655 ENOG4105FDF Could be involved in DNA repair (By similarity) A3858_10665 ENOG4108UT2 hemolysin iii A3858_10675 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_10680 ENOG410605C May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) A3858_10685 ENOG4107S73 homocitrate synthase A3858_10690 ENOG4105C3J Cysteine desulfurase A3858_10695 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins A3858_10700 ENOG4105QAS Iron-sulfur cluster assembly accessory protein A3858_10705 ENOG4105PS4 nifq family A3858_10710 ENOG4105WCA Ferredoxin A3858_10715 ENOG4108VQE nitrogen fixation protein A3858_10720 ENOG4108UR2 Nitrogen fixation protein NifX A3858_10725 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN A3858_10760 ENOG4105XV5 nifz family A3858_10765 ENOG4108QWQ LRV FeS4 cluster domain protein A3858_10775 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB A3858_10780 ENOG4108JUA Transcriptional regulator A3858_10795 ENOG4105DZ1 carboxypeptidase A3858_10810 ENOG410814C multidrug resistance protein A3858_10820 ENOG4105D0M Protease HtpX homolog A3858_10830 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) A3858_10840 ENOG4107RQ5 Methylates ribosomal protein L11 (By similarity) A3858_10845 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A3858_10850 ENOG4105C25 Primosomal protein n' A3858_10865 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3858_10875 ENOG4105VE1 Phosphatidylcholine synthase A3858_10885 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A3858_10895 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A3858_10900 ENOG4106K28 UPF0283 membrane protein A3858_10905 ENOG4105CM6 amino acid regulated cytosolic protein A3858_10910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A3858_10915 ENOG4108IRC dna polymerase iii A3858_10920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3858_10930 ENOG41080XQ Signal transduction protein with cbs domains A3858_10935 ENOG4107QN1 sodium solute A3858_10945 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A3858_10950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A3858_10975 ENOG4105DK7 lysyl-tRNA synthetase A3858_10980 ENOG4108Z9K Osmotically inducible protein A3858_10990 ENOG4105C5H ABC transporter A3858_11020 ENOG4105CBG Sulfatase A3858_11030 ENOG4105DGW oligopeptidase A A3858_11035 ENOG4105D06 uba thif-type nad fad binding protein A3858_11040 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A3858_11045 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A3858_11055 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_11075 ENOG4105DTT CRISPR-associated helicase, cas3 A3858_11080 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A3858_11085 ENOG4108KPJ rna polymerase sigma factor A3858_11095 ENOG4105CHR reductase A3858_11100 ENOG4105KVH Transcriptional regulator A3858_11135 ENOG4105C9U ATP-dependent DNA helicase RecQ A3858_11155 ENOG4108Z03 MAF-like protein A3858_11165 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A3858_11180 ENOG4108UXE Protein tyrosine phosphatase A3858_11185 ENOG4108ZTZ UPF0262 protein A3858_11190 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A3858_11200 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A3858_11215 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_11235 ENOG4105CJP fad dependent oxidoreductase A3858_11250 ENOG4108IMY Transcriptional regulator A3858_11265 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component A3858_11270 ENOG4108YI8 ABC transporter A3858_11275 ENOG4107Z6I Thiamine biosynthesis protein A3858_11280 ENOG4105DWF phosphomethylpyrimidine kinase A3858_11285 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A3858_11290 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase A3858_11295 ENOG4105E4C Lytic transglycosylase catalytic A3858_11310 ENOG4105C6Y Udp-glucose 6-dehydrogenase A3858_11320 ENOG4105CDY transcriptional regulatory protein A3858_11330 ENOG4105D48 metallophosphoesterase A3858_11335 ENOG4107QRT dEAD DEAH box helicase A3858_11350 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A3858_11370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A3858_11375 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A3858_11385 ENOG4105KCK Peptidoglycan-associated lipoprotein A3858_11400 ENOG4108ZZF transport protein (ExbD) A3858_11405 ENOG4105E02 MotA TolQ exbB proton channel A3858_11410 ENOG4107YD3 Thioesterase A3858_11420 ENOG4107QRG dna polymerase iii A3858_11425 ENOG4105F8V Hydrolase, tatD family A3858_11450 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) A3858_11455 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A3858_11465 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) A3858_11475 ENOG4108R85 Short chain dehydrogenase A3858_11480 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) A3858_11485 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) A3858_11495 ENOG4105DZ1 carboxypeptidase A3858_11515 ENOG4105C58 cytochrome c oxidase accessory protein ccog A3858_11520 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) A3858_11535 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i A3858_11545 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A3858_11550 ENOG4105D4P Coproporphyrinogen iii oxidase A3858_11555 ENOG4105JNK Glycosyl transferase (Group 1 A3858_11560 ENOG4108JQ5 ABC transporter A3858_11565 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component A3858_11570 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component A3858_11580 ENOG4105G9V cytochrome C A3858_11610 ENOG4107QMP dna polymerase iii subunits gamma and tau A3858_11615 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A3858_11655 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme A3858_11660 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A3858_11665 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase A3858_11670 ENOG4108YXU transcriptional regulator AsnC family A3858_11675 ENOG4105DCF alanine dehydrogenase A3858_11680 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) A3858_11685 ENOG4107ZT5 Thiol disulfide interchange protein A3858_11690 ENOG4105CH7 arginosuccinase A3858_11710 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A3858_11725 ENOG4105CAK Cell division ATP-binding protein ftsE A3858_11745 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b A3858_11750 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) A3858_11780 ENOG4105CSU acyl-Coa dehydrogenase A3858_11785 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A3858_11790 ENOG4108R3E Dna-3-methyladenine glycosylase i A3858_11800 ENOG4105CHR reductase A3858_11805 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) A3858_11815 ENOG4105EAH synthase A3858_11850 ENOG4107XZX Involved in the transcription termination process (By similarity) A3858_11855 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A3858_11860 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A3858_11880 ENOG4105DAY polysaccharide export protein A3858_11900 ENOG4105CHM Aminotransferase A3858_11905 ENOG4107QI1 Mate efflux family protein A3858_11915 ENOG4105CSR polyphosphate kinase 2 A3858_11930 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3858_11935 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) A3858_11940 ENOG4105BZM domain protein A3858_11950 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) A3858_11955 ENOG4105D60 lipoprotein releasing system transmembrane protein A3858_11960 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A3858_11965 ENOG4105C02 permease A3858_11975 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) A3858_11980 ENOG4107R33 ppx gppa phosphatase A3858_11990 ENOG4108Z7F N-acetyltransferase A3858_11995 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) A3858_12015 ENOG4105EFT decarboxylase A3858_12020 ENOG4108BB0 Elp3 A3858_12030 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) A3858_12035 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) A3858_12055 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) A3858_12065 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A3858_12075 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A3858_12080 ENOG41084XA UPF0235 protein A3858_12085 ENOG4105DGU Histone deacetylase A3858_12090 ENOG4108IGT Dipeptidase A3858_12095 ENOG4108JQ7 (ABC) transporter A3858_12105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_12110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3858_12115 ENOG4105DEF Extracellular solute-binding protein, family 5 A3858_12165 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain A3858_12170 ENOG4105C1J atp-dependent rna helicase A3858_12185 ENOG4105EV9 Alpha Beta Hydrolase A3858_12195 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A3858_12200 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A3858_12205 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A3858_12225 ENOG4105DMF Dehydrogenase A3858_12240 ENOG4105C3G gtp-binding protein A3858_12245 ENOG4105CJT Mannose-1-phosphate guanylyltransferase A3858_12280 ENOG4105C8T Leucyl-tRNA synthetase A3858_12285 ENOG4105TXM Domain of unknown function (DUF3576) A3858_12300 ENOG4105DFA alanine racemase domain protein A3858_12310 ENOG4107QJN gtp cyclohydrolase ii A3858_12315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3858_12325 ENOG4108IG5 Transcriptional regulator A3858_12335 ENOG4105RK9 auxin efflux carrier A3858_12340 ENOG4105C4W S-formylglutathione hydrolase A3858_12345 ENOG4108UPT UPF0178 protein A3858_12350 ENOG4105CIF Ornithine Cyclodeaminase A3858_12365 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) A3858_12375 ENOG4108EHX EamA-like transporter family A3858_12380 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A3858_12405 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A3858_12420 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A3858_12445 ENOG4105C87 Aminotransferase class I and II A3858_12450 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A3858_12455 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A3858_12460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A3858_12465 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A3858_12485 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) A3858_12495 ENOG4107SC1 transglycosylase A3858_12500 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3858_12510 ENOG4105KHC sulfurtransferase A3858_12515 ENOG4105CGF Aromatic amino acid aminotransferase A3858_12520 ENOG4105BZU Histidine kinase A3858_12525 ENOG4108YZA Nitrogen regulatory protein pii A3858_12545 ENOG4108JJ6 Type I secretion system ATPase A3858_12575 ENOG4105KZX Pterin carbinolamine dehydratase A3858_12590 ENOG4106H78 methyltransferase A3858_12595 ENOG4107YBY Hydrolase A3858_12605 ENOG4105DSE periplasmic solute binding protein A3858_12610 ENOG4105DIK (ABC) transporter A3858_12615 ENOG4105CC5 ABC transporter A3858_12620 ENOG4105CC5 ABC transporter A3858_12625 ENOG4108ZXC Two component transcriptional regulator, luxr family A3858_12630 ENOG4105BZU Histidine kinase A3858_12635 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A3858_12640 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component A3858_12645 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_12655 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A3858_12665 ENOG4105CMS peptidase U62, modulator of DNA gyrase A3858_12670 ENOG4105ECY inositol monophosphatase A3858_12680 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A3858_12690 ENOG4108ZZF transport protein (ExbD) A3858_12720 ENOG4105CC0 LysR family Transcriptional regulator A3858_12730 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) A3858_12735 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A3858_12740 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A3858_12745 ENOG4105CN1 protease A3858_12755 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A3858_12760 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A3858_12765 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A3858_12795 ENOG4105D7T ABC transporter A3858_12805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3858_12865 ENOG4105CGH 5'-nucleotidase A3858_12875 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) A3858_12890 ENOG4105EE1 crotonyl-CoA reductase A3858_12895 ENOG4105RFZ Methylmalonyl-coA mutase A3858_12900 ENOG4107QN2 dihydrolipoyl dehydrogenase A3858_12910 ENOG4105C7S Dehydrogenase A3858_12915 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 A3858_12940 ENOG4105CI0 Citrate lyase A3858_12955 ENOG4105DJG MaoC domain protein dehydratase A3858_12960 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) A3858_12970 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) A3858_12985 ENOG4105E33 succinate dehydrogenase A3858_12995 ENOG4105DRR Transcriptional regulator, GntR family A3858_13020 ENOG4105CPN adenine deaminase A3858_13030 ENOG4107Z1W Fructose transport system kinase A3858_13035 ENOG4105C2J ABC transporter A3858_13040 ENOG4105CNN ABC, transporter A3858_13045 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator A3858_13055 ENOG4105D65 subunit l A3858_13060 ENOG4108ZE9 Monovalent cation H antiporter subunit C A3858_13065 ENOG4107R4Z monovalent cation h antiporter subunit d A3858_13070 ENOG4105SC1 monovalent cation H antiporter subunit E A3858_13075 ENOG4105W4C monovalent cation H antiporter subunit F A3858_13080 ENOG4105KJM monovalent cation h antiporter subunit g A3858_13090 ENOG4108UJU UPF0301 protein A3858_13100 ENOG4108UN4 phage SPO1 DNA polymerase-related protein A3858_13135 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) A3858_13155 ENOG4105C26 Dehydrogenase A3858_13170 ENOG4105CP2 von willebrand factor, type a A3858_13175 ENOG4108ZNX Heat shock protein A3858_13185 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A3858_13190 ENOG4105EU8 FAD linked oxidase domain protein A3858_13195 ENOG4105CQB FAD linked oxidase domain protein A3858_13220 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A3858_13240 ENOG4105C2M dna polymerase I A3858_13245 ENOG4105K59 histidine triad (HIT) protein A3858_13255 ENOG4105CSM endonuclease III A3858_13260 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A3858_13265 ENOG4108ZG0 Ompa motb domain protein A3858_13270 ENOG41073TP transcriptional regulator A3858_13275 ENOG410840P Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) A3858_13285 ENOG4105VD1 ATP synthase subunit C A3858_13295 ENOG41081E4 ATP synthase F0 subunit I A3858_13300 ENOG41082BM Transcriptional regulator, arsr family A3858_13305 ENOG4105CEY Amp-dependent synthetase and ligase A3858_13310 ENOG4107QJE Chromosome Partitioning Protein A3858_13325 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A3858_13335 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) A3858_13365 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY A3858_13385 ENOG4105CUX Signal transduction histidine kinase A3858_13405 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) A3858_13415 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) A3858_13420 ENOG4105BZU Histidine kinase A3858_13425 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A3858_13435 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A3858_13440 ENOG4106PGW Short-chain dehydrogenase reductase Sdr A3858_13460 ENOG4108ZAF Molybdopterin A3858_13470 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A3858_13475 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A3858_13480 ENOG4105CHR reductase A3858_13490 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A3858_13495 ENOG4105EGI Transcriptional regulator A3858_13505 ENOG4107QIZ NADH dehydrogenase A3858_13510 ENOG4108IEG Formate dehydrogenase Alpha subunit A3858_13515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A3858_13530 ENOG4107RA4 Glycosyl transferase (Group 1 A3858_13535 ENOG41065U4 response regulator A3858_13550 ENOG4105EMU Dehydrogenase A3858_13575 ENOG4105K6V RNA polymerase A3858_13580 ENOG4108NIX Factor ChrR A3858_13585 ENOG4107QSV RmuC domain protein A3858_13590 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A3858_13610 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A3858_13625 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A3858_13635 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) A3858_13640 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A3858_13650 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A3858_13690 ENOG4105E2K Glycosyl transferase (Group 1 A3858_13705 ENOG4108JJ6 Type I secretion system ATPase A3858_13715 ENOG4108UW5 maltose o-acetyltransferase A3858_13725 ENOG4105C0B DNA polymerase III (alpha subunit) A3858_13730 ENOG4105CVE Lytic murein transglycosylase A3858_13735 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A3858_13745 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) A3858_13755 ENOG4107VMU Membrane A3858_13760 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) A3858_13775 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A3858_13780 ENOG4105CTB Polyprenyl synthetase A3858_13785 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A3858_13795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3858_13800 ENOG41090HR transcriptional regulator A3858_13805 ENOG4105CM2 brancheD-chain amino acid aminotransferase A3858_13815 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A3858_13825 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase A3858_13870 ENOG4105C2X Arabinose 5-phosphate isomerase A3858_13885 ENOG4108IUZ ABC transporter A3858_13890 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea A3858_13895 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN A3858_13905 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) A3858_13910 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase A3858_13915 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A3858_13930 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) A3858_13935 ENOG4105M6F mutator MutT protein A3858_13940 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) A3858_13945 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A3858_13950 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A3858_13960 ENOG4105W5Q DNA repair protein (RadC A3858_13965 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A3858_13970 ENOG4105CFG Acts as a chaperone (By similarity) A3858_13980 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A3858_13985 ENOG4105C93 Xylose Isomerase A3858_13990 ENOG4105CMG Carbohydrate kinase A3858_13995 ENOG4105C2J ABC transporter A3858_14000 ENOG4108HWW ABC transporter A3858_14005 ENOG4105DFW ABC transporter A3858_14015 ENOG4105CFU surface antigen A3858_14020 ENOG4105MA0 exported protein A3858_14025 ENOG4107U9T Pfam:Ribonuclease_BN A3858_14040 ENOG4105E3R (LipO)protein A3858_14050 ENOG4105D3Q Sugar transferase A3858_14075 ENOG4105MJ2 Competence protein A3858_14085 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A3858_14100 ENOG4105F7V ErfK ybiS ycfS ynhG family protein A3858_14105 ENOG4107QS4 23S rRNA A3858_14110 ENOG4105BZ1 (ABC) transporter A3858_14115 ENOG4105BZ1 (ABC) transporter A3858_14120 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate A3858_14125 ENOG4105P8F nudix hydrolase A3858_14130 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A3858_14140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3858_14170 ENOG4105CM2 brancheD-chain amino acid aminotransferase A3858_14175 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) A3858_14180 ENOG4105C6K Malic enzyme A3858_14190 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A3858_14195 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A3858_14205 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A3858_14210 ENOG4108176 endoribonuclease L-psp A3858_14215 ENOG4105CSA Coproporphyrinogen iii oxidase A3858_14220 ENOG4105WD1 Membrane A3858_14225 ENOG4105FA0 parb-like partition protein A3858_14230 ENOG4107QJE Chromosome Partitioning Protein A3858_14235 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) A3858_14240 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) A3858_14245 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A3858_14250 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A3858_14255 ENOG4108YXA Membrane A3858_14260 ENOG4108UHJ MAF-like protein A3858_14265 ENOG4105E2X shikimate dehydrogenase A3858_14270 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A3858_14275 ENOG4107RZZ dna polymerase iii epsilon subunit A3858_14300 ENOG4105XAB Smr domain protein A3858_14310 ENOG4105ETE Transcriptional regulator (LacI family A3858_14325 ENOG4105C2J ABC transporter A3858_14330 ENOG4105CNN ABC, transporter A3858_14335 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A3858_14375 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A3858_14380 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class A3858_14385 ENOG4108MUZ hydrolase A3858_14400 ENOG4105BZU Histidine kinase A3858_14415 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A3858_14420 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A3858_14425 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) A3858_14430 ENOG4105C08 Histidine kinase A3858_14435 ENOG4105EEX Two component transcriptional regulator (Winged helix family A3858_14440 ENOG4105VDW Csbd family A3858_14460 ENOG41074H6 response regulator A3858_14470 ENOG4105DS0 Transcriptional regulator, Crp Fnr family A3858_14480 ENOG4107QKS N-acylglucosamine 2-epimerase A3858_14485 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A3858_14490 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 A3858_14495 ENOG4106F1P AAA ATPase, central domain protein A3858_14500 ENOG4108VFZ ribulose bisphosphate carboxylase, small A3858_14505 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate A3858_14510 ENOG4105D2N Aldolase A3858_14515 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) A3858_14520 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 A3858_14525 ENOG4105DUM transcriptional regulator, lysR family A3858_14530 ENOG4108IV0 ABC, transporter A3858_14535 ENOG4105C0Z ABC transporter A3858_14545 ENOG4105C32 Amino acid ABC transporter (Permease) A3858_14560 ENOG4105C26 Dehydrogenase A3858_14570 ENOG4105CPP Dehydrogenase, E1 component A3858_14575 ENOG4105C1G acyl-Coa dehydrogenase A3858_14580 ENOG4105ETT transcriptional Regulator, LysR family A3858_14585 ENOG4105CE4 GlcNAc 6-P deacetylase A3858_14610 ENOG4105ER2 Ompa motb domain protein A3858_14615 ENOG4105BZE flagellar hook protein, FlgE A3858_14630 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) A3858_14645 ENOG4105CN7 Flagellar biosynthetic protein FliP A3858_14650 ENOG4105DD5 Flagellar motor switch protein A3858_14660 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) A3858_14680 ENOG4107RD7 Flagellar Motor Protein, MotA A3858_14695 ENOG4105D7B Flagellar biosynthesis protein flha A3858_14705 ENOG4105D00 flagellar biosynthetic protein flhB A3858_14720 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) A3858_14730 ENOG4105CGA flagellar basal-body rod protein FlgG A3858_14735 ENOG4105KTQ flagellar basal-body rod protein A3858_14740 ENOG4105VS8 Flagellar biosynthetic protein fliq A3858_14745 ENOG4105X50 flagellar hook-basal body complex protein fliE A3858_14750 ENOG4108ZC9 flagellar basal-body rod protein flgc A3858_14755 ENOG4105SFI flagellar basal-body rod protein A3858_14760 ENOG4108JIR Flagellum-specific ATP synthase A3858_14785 ENOG410822I Flagellar hook capping protein A3858_14800 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A3858_14820 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A3858_14825 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A3858_14835 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A3858_14840 ENOG4105EXU Membrane A3858_14845 ENOG4105D6Z AFG1 family ATPase A3858_14850 ENOG4105EAC phosphoserine phosphatase A3858_14855 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A3858_14860 ENOG4108JQ1 Dehydrogenase A3858_14870 ENOG4105CHU acetyl-coa acetyltransferase A3858_14875 ENOG4108JQB penicillin-binding protein 1C A3858_14880 ENOG4105DN3 alpha-2-macroglobulin domain protein A3858_14885 ENOG4105BZU Histidine kinase A3858_14890 ENOG4105D1Q UPF0246 protein A3858_14895 ENOG4105C9U ATP-dependent DNA helicase RecQ A3858_14915 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) A3858_14925 ENOG4105EX9 Membrane A3858_14930 ENOG4108YZN class I peptide chain release factor A3858_14935 ENOG4107RH7 Nicotinate phosphoribosyltransferase A3858_14940 ENOG4108RWI nicotinamidase A3858_14945 ENOG4105FGE Short-chain dehydrogenase reductase Sdr A3858_14950 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 A3858_14955 ENOG4105CG3 alpha amylase, catalytic region A3858_14960 ENOG4105DCM major facilitator superfamily A3858_14970 ENOG4105CPK Glycosyl transferase (Group 1 A3858_14985 ENOG41077A9 carbonic anhydrase A3858_14995 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A3858_15000 ENOG4107SN7 NLP P60 protein A3858_15005 ENOG4105T0Z Conserved Protein A3858_15030 ENOG4105FYV Amp nucleosidase A3858_15040 ENOG4108594 Permease of the drug metabolite transporter A3858_15045 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A3858_15050 ENOG4105DP9 ABC transporter A3858_15060 ENOG4107T0D ABC, transporter A3858_15065 ENOG4105EIX cytochrome c1 A3858_15070 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A3858_15075 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A3858_15080 ENOG4108U78 Glutathione S-transferase A3858_15105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A3858_15125 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) A3858_15130 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) A3858_15140 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A3858_15150 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) A3858_15205 ENOG4105YAJ CopG Arc MetJ A3858_15250 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A3858_15270 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A3858_15275 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) A3858_15300 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A3858_15315 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) A3858_15320 ENOG4105CTD carboxy-peptidase A3858_15350 ENOG4105CI2 imidazolone-5-propionate hydrolase A3858_15415 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme A3858_15460 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A3858_15470 ENOG4107SQD Transcriptional regulator, GntR family A3858_15475 ENOG4105C58 cytochrome c oxidase accessory protein ccog A3858_15480 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A3858_15490 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3858_15495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_15500 ENOG4105C3U ABC transporter A3858_15515 ENOG4107Y80 Major Facilitator superfamily A3858_15530 ENOG4105D38 putrescine abc transporter A3858_15535 ENOG4105F38 ABC transporter, permease A3858_15545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_15555 ENOG4105BZU Histidine kinase A3858_15560 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A3858_15565 ENOG4105CUW cytochrome C-TYPE protein A3858_15575 ENOG4108J2R molybdopterin oxidoreductase A3858_15580 ENOG4105CVM Molybdenum cofactor synthesis domain protein A3858_15585 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A3858_15600 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase A3858_15605 ENOG4105FBA Phospholipase Carboxylesterase A3858_15625 ENOG4108IJ7 Glycine betaine A3858_15630 ENOG4108HQS Glycine betaine A3858_15650 ENOG4105CHR reductase A3858_15655 ENOG4105CEY Amp-dependent synthetase and ligase A3858_15660 ENOG4105E98 transcriptional regulator DeoR family A3858_15670 ENOG4106UW1 Major Facilitator superfamily A3858_15685 ENOG4108YYH Nadph-dependent fmn reductase A3858_15720 ENOG41067HS methyltransferase A3858_15725 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein A3858_15740 ENOG4105C94 Transporter A3858_15745 ENOG4105BZ1 (ABC) transporter A3858_15755 ENOG4105C8Q Methyl-accepting chemotaxis A3858_15765 ENOG4105DIJ Phosphoethanolamine transferase A3858_15775 ENOG4105DHQ Histidine kinase A3858_15780 ENOG4105XJC Two component transcriptional regulator (Winged helix family A3858_15790 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA A3858_15805 ENOG4105HFZ Membrane A3858_15815 ENOG4105EMN RNA polymerase sigma factor A3858_15825 ENOG4105BZ9 Cytochrome C oxidase, subunit I A3858_15830 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) A3858_15855 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A3858_15875 ENOG410903D sensor protein A3858_15895 ENOG4105C8Q Methyl-accepting chemotaxis A3858_15920 ENOG4105MWK D-amino acid dehydrogenase, small subunit A3858_15935 ENOG4105DSF transport protein A3858_15945 ENOG4108MEK Metal-binding protein YodA A3858_15970 ENOG4105CHF Glutathione S-transferase A3858_15975 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b A3858_15990 ENOG4105D6J arsenicaL-resistance protein A3858_16005 ENOG4107WDG serine threonine protein kinase A3858_16015 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) A3858_16025 ENOG4105E6M Sulphatase-modifying factor protein A3858_16035 ENOG4105D9P serine threonine protein kinase A3858_16050 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain A3858_16055 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A3858_16075 ENOG4107QN1 sodium solute A3858_16085 ENOG4105HMI Membrane A3858_16100 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) A3858_16115 ENOG4105E33 succinate dehydrogenase A3858_16130 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A3858_16140 ENOG4105C7K acetolactate synthase A3858_16155 ENOG4105CMI transporter A3858_16160 ENOG4105CJ1 ABC, transporter A3858_16165 ENOG4105D0S secretion protein (HlyD A3858_16170 ENOG4107UXM Membrane A3858_16195 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A3858_16200 ENOG4105D7T ABC transporter A3858_16215 ENOG4105JSC dimethylmenaquinone methyltransferase A3858_16220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A3858_16225 ENOG4105HF0 Membrane A3858_16230 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease A3858_16240 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A3858_16250 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) A3858_16255 ENOG41090R7 Ferric uptake A3858_16265 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F A3858_16270 ENOG4105C1G acyl-Coa dehydrogenase A3858_16280 ENOG4105CHU acetyl-coa acetyltransferase A3858_16285 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) A3858_16305 ENOG41081YB ApbE family A3858_16315 ENOG4107IVC 4Fe-4S ferredoxin, iron-sulfur binding A3858_16320 ENOG4105KXW Ferredoxin A3858_16325 ENOG4105CNW domain protein A3858_16335 ENOG4108R3D Electron transport complex A3858_16340 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) A3858_16350 ENOG4108UQQ Electron transport complex A3858_16355 ENOG4108E8M Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) A3858_16360 ENOG4105VDB UPF0125 protein A3858_16370 ENOG4105CFG Acts as a chaperone (By similarity) A3858_16375 ENOG4105CPC Aldo Keto reductase A3858_16380 ENOG4105CF7 AraC family transcriptional regulator A3858_16385 ENOG4105ECQ AraC Family Transcriptional Regulator A3858_16395 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding A3858_16400 ENOG4105C7W Xanthine dehydrogenase A3858_16410 ENOG4105G01 cobalamin (vitamin B12) biosynthesis CbiM protein A3858_16430 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A3858_16435 ENOG4105C4M (Ubiquinol oxidase) subunit I A3858_16445 ENOG4106D4I domain protein A3858_16450 ENOG4107VRP DNA repair exonuclease A3858_16455 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase A3858_16465 ENOG4105BZU Histidine kinase A3858_16475 ENOG4105CM4 permease protein A3858_16480 ENOG4108IPW abc transporter atp-binding protein A3858_16485 ENOG4105D05 Receptor A3858_16495 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A3858_16510 ENOG4105CVE Lytic murein transglycosylase A3858_16520 ENOG4105DEF Extracellular solute-binding protein, family 5 A3858_16525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A3858_16530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_16540 ENOG4108JQ7 (ABC) transporter A3858_16545 ENOG4108UYE Lactoylglutathione lyase A3858_16555 ENOG41062D9 Histidine kinase A3858_16580 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) A3858_16590 ENOG4108JQ6 ABC transporter A3858_16595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_16605 ENOG4108JQ6 ABC transporter A3858_16610 ENOG4107SCA Formamidase (EC 3.5.1.49) A3858_16615 ENOG4105DEF Extracellular solute-binding protein, family 5 A3858_16625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_16635 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein A3858_16640 ENOG4105C8Y Acetylornithine aminotransferase A3858_16665 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 A3858_16670 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) A3858_16680 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A3858_16725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) A3858_16730 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) A3858_16740 ENOG4105DH8 myo-inositol catabolism A3858_16745 ENOG4108IJ9 (ABC) transporter A3858_16755 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component A3858_16760 ENOG4108IJG ABC transporter substrate-binding protein A3858_16765 ENOG4105EAM Na Pi-cotransporter A3858_16780 ENOG4105C32 Amino acid ABC transporter (Permease) A3858_16785 ENOG4108IV0 ABC, transporter A3858_16790 ENOG4105C0Z ABC transporter A3858_16820 ENOG4108RTU Aldolase A3858_16825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A3858_16830 ENOG4105C8Q Methyl-accepting chemotaxis A3858_16860 ENOG4108RNG Permease of the drug metabolite transporter A3858_16870 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A3858_16930 ENOG4105BZS acriflavin resistance protein A3858_16935 ENOG4105C1P efflux transporter, rnd family, mfp subunit A3858_16940 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family A3858_16950 ENOG41061ZR Transcriptional regulator A3858_16960 ENOG4105KJF protein tyrosine phosphatase A3858_16995 ENOG41067MG lrgb family A3858_17005 ENOG410633P Hydantoin racemase A3858_17015 ENOG4105F38 ABC transporter, permease A3858_17025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_17040 ENOG4105FR1 rard protein A3858_17045 ENOG4108UQY Iron-storage protein A3858_17055 ENOG4105BZU Histidine kinase A3858_17060 ENOG4105DSF transport protein A3858_17140 ENOG4105II7 pyrroline-5-carboxylate reductase A3858_17145 ENOG4108Z7R Chaperone CsaA A3858_17165 ENOG4105BZU Histidine kinase A3858_17170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A3858_17175 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_17185 ENOG4105CH5 extracellular solute-binding protein, family 7 A3858_17190 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) A3858_17195 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) A3858_17205 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) A3858_17230 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A3858_17245 ENOG4105CMJ mandelate racemase muconate lactonizing A3858_17250 ENOG4105EJC lysr family transcriptional regulator A3858_17270 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A3858_17275 ENOG4105E0A ABC, transporter A3858_17280 ENOG4105EHG Permease protein A3858_17290 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component A3858_17295 ENOG4105F38 ABC transporter, permease A3858_17305 ENOG4105C4Y ABC transporter A3858_17310 ENOG4105JSC dimethylmenaquinone methyltransferase A3858_17320 ENOG4107NQ8 LysR family Transcriptional regulator A3858_17325 ENOG4106TD9 Diguanylate cyclase A3858_17330 ENOG4105BZU Histidine kinase A3858_17340 ENOG4107S2N Type III effector Hrp-dependent A3858_17360 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3858_17370 ENOG4105JN3 extra-cytoplasmic solute receptor family protein A3858_17380 ENOG4105C0A alcohol dehydrogenase A3858_17385 ENOG4105E0A ABC, transporter A3858_17390 ENOG4108IHU transport system permease protein A3858_17395 ENOG4105DQ5 transport system permease protein A3858_17405 ENOG4105E0K tonB-dependent siderophore receptor A3858_17420 ENOG4105C8Q Methyl-accepting chemotaxis A3858_17435 ENOG4105CGK Exodeoxyribonuclease III A3858_17450 ENOG4106032 Glutathionylspermidine synthase A3858_17470 ENOG4105XJC Two component transcriptional regulator (Winged helix family A3858_17475 ENOG4105DHQ Histidine kinase A3858_17480 ENOG4105C8Q Methyl-accepting chemotaxis A3858_17485 ENOG4105MRR Transcriptional regulator (By similarity) A3858_17500 ENOG4105EGI Transcriptional regulator A3858_17515 ENOG4105CHM Aminotransferase A3858_17520 ENOG4105CHR reductase A3858_17525 ENOG4105JSC dimethylmenaquinone methyltransferase A3858_17530 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase A3858_17535 ENOG4107SCA Formamidase (EC 3.5.1.49) A3858_17545 ENOG4105DRR Transcriptional regulator, GntR family A3858_17560 ENOG4105DRR Transcriptional regulator, GntR family A3858_17565 ENOG4107R7A Allophanate hydrolase subunit 2 A3858_17570 ENOG4105P4J Allophanate hydrolase, subunit 1 A3858_17575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_17585 ENOG4108ERU trap dicarboxylate transporter subunit DctP A3858_17590 ENOG4105E7W lamb ycsf family protein A3858_17595 ENOG4105F0I Aminotransferase A3858_17615 ENOG4105E5Q amino acid AbC transporter A3858_17620 ENOG4105EAD ABC transporter A3858_17645 ENOG4107XWI flavin reductase domain protein, FMN-binding A3858_17685 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A3858_17710 ENOG4108WC9 type VI secretion system effector, hcp1 family A3858_17775 ENOG4108ZF3 Phosphatase A3858_17825 ENOG4105D4B ABC, transporter A3858_17830 ENOG4105F5R ABC transporter A3858_17835 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane A3858_17845 ENOG4105DKT Transcriptional regulator A3858_17880 ENOG4107ZY3 Histidine kinase A3858_17885 ENOG4105BZU Histidine kinase A3858_17900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_17905 ENOG4105F38 ABC transporter, permease A3858_17910 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component A3858_17915 ENOG4105CTU Proline racemase A3858_17925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A3858_17935 ENOG4105DEF Extracellular solute-binding protein, family 5 A3858_17940 ENOG4105DEF Extracellular solute-binding protein, family 5 A3858_17945 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A3858_17950 ENOG41067B5 Histone deacetylase superfamily protein A3858_17970 ENOG4105CEY Amp-dependent synthetase and ligase A3858_17975 ENOG4105C26 Dehydrogenase A3858_17990 ENOG4105CHU acetyl-coa acetyltransferase A3858_17995 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein A3858_18045 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) A3858_18050 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit A3858_18055 ENOG4105CUT histidyl-tRNA synthetase A3858_18065 ENOG4105C0B DNA polymerase III (alpha subunit) A3858_18085 ENOG4108JQ9 ABC transporter A3858_18090 ENOG4105UIB (ABC) transporter A3858_18105 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase A3858_18110 ENOG4105FC8 fad dependent oxidoreductase A3858_18125 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A3858_18130 ENOG4105FAV ABC, transporter A3858_18135 ENOG4105FDK ABC transporter A3858_18145 ENOG4105NXV High-affinity zinc uptake system protein A3858_18160 ENOG4105C84 Histidine ammonia-lyase A3858_18165 ENOG4108XNA Gas vesicle A3858_18175 ENOG4107ETC gas vesicle protein A3858_18200 ENOG4105MYT Heat shock protein A3858_18205 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) A3858_18230 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A3858_18240 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase A3858_18250 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) A3858_18255 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) A3858_18260 ENOG4105CAT Cytidine monophosphate kinase A3858_18265 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A3858_18270 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A3858_18285 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) A3858_18290 ENOG4108JU5 Magnesium and cobalt efflux protein A3858_18295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A3858_18300 ENOG4105C9A Phoh family A3858_18305 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A3858_18310 ENOG4108UJV acyl-CoA thioesterase i A3858_18315 ENOG4108I0Y (ABC) transporter A3858_18320 ENOG4105CV6 ABC transporter, permease A3858_18330 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) A3858_18340 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A3858_18370 ENOG4105Y2X UPF0335 protein A3858_18425 ENOG4105E2V Glycosyltransferase 36 A3858_18575 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein A3858_18615 ENOG4108RNS Exports L-alanine (By similarity) A3858_18635 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase A3858_18645 ENOG4105JSC dimethylmenaquinone methyltransferase A3858_18660 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A3858_18665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_18670 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter A3858_18675 ENOG41073TP transcriptional regulator A3858_18685 ENOG4105VJY transcriptional regulator A3858_18705 ENOG4107TTA Xylose isomerase domain protein TIM barrel A3858_18715 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component A3858_18730 ENOG4107XBN GntR Family Transcriptional Regulator A3858_18735 ENOG4108IJ9 (ABC) transporter A3858_18785 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A3858_18795 ENOG4105CNN ABC, transporter A3858_18810 ENOG4108RVA ribokinase A3858_18825 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) A3858_18830 ENOG4108IJ6 ABC transporter A3858_18835 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein A3858_18840 ENOG4108I5D sulfate abc transporter A3858_18845 ENOG4105ECW sulfate abc transporter A3858_18860 ENOG4105C2J ABC transporter A3858_18865 ENOG4107RNG ABC transporter A3858_18875 ENOG4105EF1 ribulokinase A3858_18885 ENOG4105CEP NADH dehydrogenase A3858_18890 ENOG4105C8Q Methyl-accepting chemotaxis A3858_18900 ENOG4105W4C monovalent cation H antiporter subunit F A3858_18905 ENOG4105SC1 monovalent cation H antiporter subunit E A3858_18910 ENOG4107R4Z monovalent cation h antiporter subunit d A3858_18915 ENOG4108ZE9 Monovalent cation H antiporter subunit C A3858_18920 ENOG4105D65 subunit l A3858_18975 ENOG410890F Dynamin family A3858_18980 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A3858_18990 ENOG4105CYM Glutathione S-transferase A3858_18995 ENOG4107FB0 transcriptional regulator DeoR family A3858_19000 ENOG4105D4B ABC, transporter A3858_19005 ENOG4105C2J ABC transporter A3858_19010 ENOG4105CNN ABC, transporter A3858_19015 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane A3858_19035 ENOG4105C26 Dehydrogenase A3858_19040 ENOG4105E89 ABC transporter A3858_19045 ENOG4105CYW agmatinase A3858_19050 ENOG4105E5Q amino acid AbC transporter A3858_19100 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A3858_19170 ENOG4105K8R UPF0145 protein A3858_19345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A3858_19360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A3858_19365 ENOG4108RW8 Universal stress protein F A3858_19495 ENOG41064N2 Protein of unknown function (DUF2726) A3858_19505 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A3858_19710 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A3858_19715 ENOG41064N2 Protein of unknown function (DUF2726) A3858_19730 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) A3858_19820 ENOG4105E5H Transposase A3858_19825 ENOG4108NIW Leucine export protein LeuE A3858_19855 ENOG4107S73 homocitrate synthase A3858_19890 ENOG4108ZQS transposase A3858_19910 ENOG410684T prevent-host-death family A3858_19985 ENOG4105BZU Histidine kinase A3858_20005 ENOG4105CHH sulfate transporter A3858_20015 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) A3858_20025 ENOG4105KBH arsR family transcriptional regulator A3858_20030 ENOG4107S21 permease A3858_20045 ENOG4107QM5 aconitate hydratase A3858_20065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A3858_20190 ENOG4107WCG it plays a direct role in the translocation of protons across the membrane (By similarity) A3858_20210 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A3858_20265 ENOG4105R1U AraC Family Transcriptional Regulator A3858_20275 ENOG4105PGM cation diffusion facilitator family transporter A3858_20290 ENOG4105E0K tonB-dependent siderophore receptor A3858_20300 ENOG4105S6R Iron-hydroxamate transporter permease subunit A3858_20305 ENOG4105E0A ABC, transporter A3858_20325 ENOG4105N14 lysine exporter protein LysE YggA A3858_20335 ENOG4108MXF Alpha Beta Hydrolase A3858_20360 ENOG4105CHH sulfate transporter A3858_20370 ENOG4105NXH GreA GreB family elongation factor A3858_20375 ENOG4105DRR Transcriptional regulator, GntR family A3858_20380 ENOG4106R87 Extracellular solute-binding protein, family 5 A3858_20395 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr A3858_20400 ENOG4106517 Short-chain dehydrogenase reductase Sdr A3858_20405 ENOG4105CXK mandelate racemase muconate lactonizing A3858_20410 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase A3858_20420 ENOG4105DIA mandelate racemase muconate lactonizing A3858_20430 ENOG4108JQ7 (ABC) transporter A3858_20440 ENOG4105IE4 repressor protein FlbT A3858_20450 ENOG4107W75 Flagellin A3858_20465 ENOG4105JXH GntR family transcriptional regulator A3858_20470 ENOG4105F4R Transcriptional regulator mode A3858_20475 ENOG4107XWS modD protein A3858_20485 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A3858_20490 ENOG4105E0C molybdate abc transporter A3858_20495 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) A3858_20505 ENOG4105X1V Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A3858_20515 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family A3858_20530 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) A3858_20535 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein A3858_20540 ENOG4108I5D sulfate abc transporter A3858_20545 ENOG4105ECW sulfate abc transporter A3858_20550 ENOG4108IJ6 ABC transporter A3858_20555 ENOG4108XM1 transcriptional regulator AsnC family A3858_20560 ENOG4105EN6 Membrane A3858_20595 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A3858_20620 ENOG4105C1B dTDP-glucose 4-6-dehydratase A3858_20720 ENOG4105BZU Histidine kinase A3858_20745 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS A3858_20830 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A3858_20915 ENOG4105BZU Histidine kinase A3858_20965 ENOG4105C30 Nad-dependent epimerase dehydratase A3858_20970 ENOG4107Y5K Resolvase A3858_21005 ENOG4108UW5 maltose o-acetyltransferase A3858_21025 ENOG4105DAY polysaccharide export protein A3858_21030 ENOG4105KJF protein tyrosine phosphatase A3858_21075 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A A3858_21080 ENOG4105VGJ Virulence-associated protein A3858_21170 ENOG4105ETT transcriptional Regulator, LysR family A3858_21175 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit A3858_21195 ENOG410903D sensor protein A3858_21270 ENOG4105ECQ AraC Family Transcriptional Regulator A3858_21275 ENOG4105GIJ Glycine betaine A3858_21280 ENOG4108HQS Glycine betaine A3858_21285 ENOG4108IJ7 Glycine betaine A3858_21295 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A3858_21300 ENOG4105C26 Dehydrogenase A3858_21315 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A3858_21320 ENOG4107WEA mandelate racemase muconate lactonizing A3858_21325 ENOG4105F5V trimethylamine methyltransferase A3858_21330 ENOG4108E94 phosphate acetyltransferase A3858_21345 ENOG4105CJP fad dependent oxidoreductase A3858_21355 ENOG4105CG6 trap dicarboxylate transporter dctm subunit A3858_21365 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit A3858_21370 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A3858_21375 ENOG4105BZU Histidine kinase A3858_21390 ENOG4105C9Q fumarate hydratase class II A3858_21415 ENOG4105EU0 Major facilitator Superfamily A3858_21420 ENOG4108KK1 membrane protein AbrB duplication A3858_21435 ENOG4108MGF sugar kinase A3858_21440 ENOG4105D2M Aldolase A3858_21445 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A3858_21450 ENOG4105C26 Dehydrogenase A3858_21455 ENOG4105CPQ Dehydrogenase A3858_21460 ENOG4108IJ9 (ABC) transporter A3858_21465 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component A3858_21480 ENOG4105E98 transcriptional regulator DeoR family A3858_21495 ENOG4105ETE Transcriptional regulator (LacI family A3858_21510 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component A3858_21515 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component A3858_21525 ENOG4108KPW sugar kinase A3858_21530 ENOG4105CJP fad dependent oxidoreductase A3858_21535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A3858_21540 ENOG4105FDP GntR family transcriptional regulator A3858_21545 ENOG4105HDK L-asparaginase A3858_21550 ENOG4105CDA abc transporter atp-binding protein A3858_21560 ENOG4105E5Q amino acid AbC transporter A3858_21565 ENOG4105DRP amino acid AbC transporter A3858_21575 ENOG4106IQC argininosuccinate lyase A3858_21585 ENOG4108VQN 4-hydroxyphenylacetate 3-monooxygenase reductase A3858_21590 ENOG4105CHR reductase A3858_21600 ENOG4106NZI LysR family Transcriptional regulator A3858_21610 ENOG4105F2Z 3-oxoadipate enol-lactonase A3858_21620 ENOG4108IV0 ABC, transporter A3858_21625 ENOG4105C0Z ABC transporter A3858_21630 ENOG4105CF8 branched-chain amino acid ABC transporter, permease A3858_21635 ENOG4105C32 Amino acid ABC transporter (Permease) A3858_21660 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A3858_21665 ENOG4105J0Q Transcriptional regulator A3858_21715 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A3858_21725 ENOG4105D2N Aldolase A3858_21730 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A3858_21740 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19)