locus-tag	class	description
A3858_00055	COG0662	Cupin 2, conserved barrel domain protein
A3858_00060	COG0604	alcohol dehydrogenase
A3858_00065	COG1309	transcriptional regulator
A3858_00070	COG0488	(ABC) transporter
A3858_00075	COG1120	ATPase activity
A3858_00085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3858_00090	COG4774	siderophore transport
A3858_00095	COG1940	carbohydrate kinase activity
A3858_00105	COG1175	transmembrane transport
A3858_00110	COG0395	ABC-type sugar transport system, permease component
A3858_00120	COG2971	BadF BadG BcrA BcrD
A3858_00135	COG1349	DNA-binding transcription factor activity
A3858_00150	COG0601	transmembrane transport
A3858_00165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3858_00185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3858_00205	COG1519	Transferase
A3858_00210	COG1663	tetraacyldisaccharide 4'-kinase activity
A3858_00230	COG1194	a g-specific adenine glycosylase
A3858_00240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A3858_00245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3858_00270	COG0019	diaminopimelate decarboxylase activity
A3858_00290	COG4172	Belongs to the ABC transporter superfamily
A3858_00295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3858_00300	COG0601	transmembrane transport
A3858_00305	COG4166	transmembrane transport
A3858_00325	COG1309	transcriptional regulator
A3858_00330	COG5507	3-demethylubiquinone-9 3-methyltransferase
A3858_00340	COG3118	belongs to the thioredoxin family
A3858_00350	COG2835	tetraacyldisaccharide 4'-kinase activity
A3858_00355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3858_00360	COG0154	amidase activity
A3858_00365	COG0436	Aminotransferase
A3858_00370	COG1674	ftsk spoiiie
A3858_00390	COG0405	Gamma-glutamyltransferase
A3858_00420	COG0564	pseudouridine synthase activity
A3858_00455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3858_00460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A3858_00475	COG0133	tryptophan synthase activity
A3858_00490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A3858_00500	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A3858_00505	COG1999	signal sequence binding
A3858_00510	COG2205	protein histidine kinase activity
A3858_00515	COG2205	protein histidine kinase activity
A3858_00525	COG3178	'Phosphotransferase
A3858_00530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3858_00535	COG2887	Belongs to the helicase family. UvrD subfamily
A3858_00540	COG1074	ATP-dependent DNA helicase activity
A3858_00555	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A3858_00560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A3858_00565	COG1696	Membrane protein involved in D-alanine export
A3858_00595	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3858_00600	COG0463	Glycosyl transferase, family 2
A3858_00615	COG1136	(ABC) transporter
A3858_00655	COG1414	Transcriptional regulator
A3858_00665	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A3858_00670	COG3257	ureidoglycine aminohydrolase activity
A3858_00680	COG2351	hydroxyisourate hydrolase activity
A3858_00695	COG0538	isocitrate dehydrogenase activity
A3858_00700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3858_00705	COG0318	PFAM AMP-dependent synthetase and ligase
A3858_00710	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3858_00715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3858_00720	COG0628	permease
A3858_00740	COG0174	glutamine synthetase
A3858_00745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A3858_00750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3858_00775	COG3038	cytochrome b561
A3858_00780	COG0529	Catalyzes the synthesis of activated sulfate
A3858_00780	COG2046	Belongs to the sulfate adenylyltransferase family
A3858_00785	COG0492	ferredoxin-NADP+ reductase activity
A3858_00790	COG1522	sequence-specific DNA binding
A3858_00805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A3858_00820	COG0745	RESPONSE REGULATOR receiver
A3858_00830	COG0835	chemotaxis
A3858_00835	COG0835	chemotaxis
A3858_00845	COG2201	protein-glutamate methylesterase activity
A3858_00855	COG0435	Glutathione S-transferase
A3858_00860	COG2204	response regulator
A3858_00875	COG0280	phosphate acetyltransferase
A3858_00875	COG0281	malic enzyme
A3858_00880	COG0295	cytidine deaminase activity
A3858_00885	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3858_00890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A3858_00895	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A3858_00900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3858_00930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3858_00940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3858_00945	COG2186	Transcriptional regulator
A3858_00950	COG1802	Transcriptional regulator
A3858_00955	COG1063	alcohol dehydrogenase
A3858_00960	COG0246	Mannitol dehydrogenase
A3858_00965	COG2721	sulfolactate sulfo-lyase activity
A3858_00970	COG4191	Histidine kinase
A3858_00975	COG2204	response regulator
A3858_01035	COG3920	Histidine kinase
A3858_01040	COG2197	response regulator
A3858_01120	COG0730	response to heat
A3858_01190	COG3750	Belongs to the UPF0335 family
A3858_01215	COG1609	Transcriptional regulator
A3858_01230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A3858_01240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A3858_01250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3858_01265	COG0736	holo-[acyl-carrier-protein] synthase activity
A3858_01270	COG0681	Belongs to the peptidase S26 family
A3858_01280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A3858_01290	COG1381	Involved in DNA repair and RecF pathway recombination
A3858_01305	COG0745	RESPONSE REGULATOR receiver
A3858_01310	COG2205	protein histidine kinase activity
A3858_01320	COG1660	Displays ATPase and GTPase activities
A3858_01330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3858_01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3858_01360	COG2096	Adenosyltransferase
A3858_01370	COG0300	oxidoreductase activity
A3858_01380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3858_01415	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3858_01425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A3858_01430	COG0222	ribosome binding
A3858_01440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3858_01445	COG0697	spore germination
A3858_01460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3858_01475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3858_01515	COG0255	Belongs to the universal ribosomal protein uL29 family
A3858_01535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3858_01575	COG0201	protein transport
A3858_01610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3858_01615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3858_01625	COG0564	pseudouridine synthase activity
A3858_01635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3858_01640	COG4597	amino acid ABC transporter
A3858_01645	COG0765	amino acid transport
A3858_01650	COG1126	abc transporter atp-binding protein
A3858_01685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A3858_01690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3858_01705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3858_01705	COG0072	phenylalanine-tRNA ligase activity
A3858_01735	COG0469	pyruvate kinase activity
A3858_01750	COG4948	Mandelate Racemase Muconate Lactonizing
A3858_01775	COG2076	Multidrug Resistance protein
A3858_01780	COG2133	pyrroloquinoline quinone binding
A3858_01805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A3858_01840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3858_01840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3858_01845	COG1105	Belongs to the carbohydrate kinase PfkB family
A3858_01850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3858_01850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3858_01855	COG1742	UPF0060 membrane protein
A3858_01860	COG0789	Transcriptional regulator
A3858_01865	COG2217	Heavy metal translocating P-type atpase
A3858_01870	COG0629	single-stranded DNA binding
A3858_01875	COG0741	lytic transglycosylase activity
A3858_01880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3858_01885	COG2032	superoxide dismutase activity
A3858_01895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3858_01900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3858_01905	COG3737	Protein of unknown function (DUF498/DUF598)
A3858_01910	COG4133	protoheme IX ABC transporter activity
A3858_01915	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3858_01920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3858_01930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3858_01935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3858_01950	COG0180	Tryptophanyl-tRNA synthetase
A3858_01960	COG0728	peptidoglycan biosynthetic process
A3858_01965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A3858_01975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A3858_01980	COG0792	nuclease activity
A3858_01985	COG0189	ligase activity
A3858_01990	COG0606	chelatase, subunit chli
A3858_02005	COG1918	ferrous iron import across plasma membrane
A3858_02015	COG3685	Protein conserved in bacteria
A3858_02020	COG0243	molybdopterin cofactor binding
A3858_02025	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A3858_02030	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3858_02040	COG0312	modulator of DNA gyrase
A3858_02055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A3858_02075	COG0612	Peptidase, M16
A3858_02095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3858_02100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3858_02105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3858_02120	COG2917	probably involved in intracellular septation
A3858_02130	COG0552	protein localization to endoplasmic reticulum
A3858_02140	COG1570	exodeoxyribonuclease VII activity
A3858_02150	COG0151	Belongs to the GarS family
A3858_02155	COG0469	pyruvate kinase activity
A3858_02160	COG0527	aspartate kinase activity
A3858_02180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3858_02185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3858_02195	COG0752	glycyl-tRNA synthetase alpha subunit
A3858_02205	COG0751	glycine-tRNA ligase activity
A3858_02210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3858_02210	COG0574	Belongs to the PEP-utilizing enzyme family
A3858_02220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A3858_02230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3858_02240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A3858_02245	COG1522	sequence-specific DNA binding
A3858_02250	COG1522	sequence-specific DNA binding
A3858_02275	COG1802	Transcriptional regulator
A3858_02290	COG0505	Belongs to the CarA family
A3858_02310	COG0321	lipoyl(octanoyl) transferase activity
A3858_02325	COG3842	ATPase activity
A3858_02335	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_02340	COG1177	transmembrane transport
A3858_02355	COG0670	Belongs to the BI1 family
A3858_02365	COG0583	DNA-binding transcription factor activity
A3858_02370	COG3321	synthase
A3858_02370	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_02370	COG0604	alcohol dehydrogenase
A3858_02385	COG3773	Cell wall hydrolase
A3858_02390	COG0668	transmembrane transport
A3858_02395	COG0402	S-adenosylhomocysteine deaminase activity
A3858_02400	COG2239	Acts as a magnesium transporter
A3858_02405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3858_02455	COG4964	Belongs to the GSP D family
A3858_02475	COG0741	lytic transglycosylase activity
A3858_02500	COG0583	DNA-binding transcription factor activity
A3858_02530	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A3858_02535	COG2258	MOSC domain
A3858_02550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3858_02555	COG1268	BioY protein
A3858_02565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3858_02570	COG0730	response to heat
A3858_02575	COG0305	Participates in initiation and elongation during chromosome replication
A3858_02580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3858_02585	COG0418	dihydroorotase activity
A3858_02610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A3858_02620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A3858_02640	COG0175	sulfate reduction
A3858_02645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3858_02655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A3858_02655	COG1648	precorrin-2 dehydrogenase activity
A3858_02660	COG1522	sequence-specific DNA binding
A3858_02670	COG0149	triose-phosphate isomerase activity
A3858_02680	COG2151	metal-sulfur cluster biosynthetic enzyme
A3858_02695	COG1278	Cold shock
A3858_02700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3858_02725	COG3436	PFAM IS66 Orf2 family protein
A3858_02765	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3858_02770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A3858_02775	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A3858_02785	COG2166	iron-sulfur cluster assembly
A3858_02795	COG0006	proline dipeptidase activity
A3858_02820	COG0484	heat shock protein binding
A3858_02830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A3858_02840	COG0308	aminopeptidase N
A3858_02850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3858_02860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3858_02875	COG0525	valine-tRNA ligase activity
A3858_02905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3858_02910	COG0658	competence protein
A3858_02910	COG2333	competence protein COMEC
A3858_02915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3858_02920	COG0303	'Molybdopterin
A3858_02925	COG0315	cyclic pyranopterin monophosphate synthase activity
A3858_02930	COG0134	indole-3-glycerol-phosphate synthase activity
A3858_02935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3858_02950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A3858_02970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A3858_02975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3858_02985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3858_02995	COG1643	Atp-dependent helicase
A3858_03005	COG1703	isobutyryl-CoA mutase activity
A3858_03040	COG1858	cytochrome C peroxidase
A3858_03055	COG1278	Cold shock
A3858_03065	COG0583	DNA-binding transcription factor activity
A3858_03080	COG3920	Histidine kinase
A3858_03080	COG2202	Pas domain
A3858_03255	COG4695	Portal protein
A3858_03325	COG3750	Belongs to the UPF0335 family
A3858_03360	COG0556	nucleotide-excision repair
A3858_03390	COG0481	GTPase activity
A3858_03400	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A3858_03405	COG0210	DNA helicase
A3858_03410	COG3135	benzoate transporter
A3858_03420	COG0489	protein tyrosine kinase activity
A3858_03430	COG0275	rRNA processing
A3858_03445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3858_03465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A3858_03485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A3858_03490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A3858_03500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A3858_03510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A3858_03515	COG0849	cell division
A3858_03520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3858_03530	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3858_03545	COG0277	FAD linked oxidase domain protein
A3858_03555	COG5012	cobalamin binding
A3858_03565	COG0646	methionine synthase
A3858_03565	COG1410	methionine synthase
A3858_03575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3858_03580	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3858_03585	COG0047	phosphoribosylformylglycinamidine synthase activity
A3858_03595	COG2204	response regulator
A3858_03610	COG0785	Cytochrome C biogenesis protein
A3858_03630	COG0114	fumarate hydratase activity
A3858_03650	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3858_03655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3858_03660	COG0415	Belongs to the DNA photolyase family
A3858_03665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A3858_03675	COG0494	nUDIX hydrolase
A3858_03685	COG3264	Mechanosensitive ion channel
A3858_03685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A3858_03690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3858_03695	COG0463	Glycosyl transferase, family 2
A3858_03725	COG1177	transmembrane transport
A3858_03740	COG3842	ATPase activity
A3858_03745	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_03765	COG1522	sequence-specific DNA binding
A3858_03785	COG0483	inositol monophosphate 1-phosphatase activity
A3858_03790	COG0306	phosphate transporter
A3858_03795	COG0583	DNA-binding transcription factor activity
A3858_03805	COG1268	BioY protein
A3858_03810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A3858_03815	COG1122	ATPase activity
A3858_03825	COG0758	DNA mediated transformation
A3858_03830	COG1754	DNA topoisomerase type I activity
A3858_03830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3858_03850	COG1309	transcriptional regulator
A3858_03855	COG1012	belongs to the aldehyde dehydrogenase family
A3858_03860	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A3858_03870	COG3800	Transcriptional regulator
A3858_03870	COG1396	sequence-specific DNA binding
A3858_03885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3858_03905	COG0439	Biotin carboxylase
A3858_03920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3858_03925	COG0509	glycine decarboxylation via glycine cleavage system
A3858_03930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3858_03930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3858_03935	COG1024	Enoyl-CoA hydratase
A3858_03935	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3858_03940	COG0183	Belongs to the thiolase family
A3858_03950	COG1960	acyl-CoA dehydrogenase activity
A3858_03975	COG0534	Mate efflux family protein
A3858_03985	COG0730	response to heat
A3858_03990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3858_04020	COG1214	PFAM Peptidase M22, glycoprotease
A3858_04025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A3858_04035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3858_04040	COG2514	catechol 2,3-dioxygenase activity
A3858_04045	COG1376	ErfK ybiS ycfS ynhG family protein
A3858_04060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3858_04065	COG3042	response to heat
A3858_04075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3858_04090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A3858_04115	COG1573	uracil-dna glycosylase
A3858_04140	COG2814	Major facilitator Superfamily
A3858_04155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3858_04160	COG1832	CoA-binding protein
A3858_04165	COG0140	phosphoribosyl-ATP diphosphatase activity
A3858_04170	COG0107	imidazoleglycerol-phosphate synthase activity
A3858_04175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A3858_04185	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3858_04190	COG0131	Imidazoleglycerol-phosphate dehydratase
A3858_04195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3858_04225	COG1132	(ABC) transporter
A3858_04230	COG0318	PFAM AMP-dependent synthetase and ligase
A3858_04235	COG1490	D-aminoacyl-tRNA deacylase activity
A3858_04245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3858_04250	COG1238	metal cluster binding
A3858_04290	COG1187	pseudouridine synthase activity
A3858_04295	COG0590	tRNA wobble adenosine to inosine editing
A3858_04300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3858_04315	COG0154	amidase activity
A3858_04325	COG3023	N-Acetylmuramoyl-L-alanine amidase
A3858_04355	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3858_04360	COG0411	ABC transporter
A3858_04370	COG1022	Amp-dependent synthetase and ligase
A3858_04400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3858_04405	COG0287	Prephenate dehydrogenase
A3858_04420	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A3858_04450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3858_04470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3858_04480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A3858_04495	COG2983	Belongs to the UPF0260 family
A3858_04500	COG0196	riboflavin kinase activity
A3858_04505	COG2030	dehydratase
A3858_04515	COG1227	inorganic diphosphatase activity
A3858_04530	COG0459	protein refolding
A3858_04545	COG0656	L-ascorbic acid biosynthetic process
A3858_04555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_04565	COG1012	belongs to the aldehyde dehydrogenase family
A3858_04570	COG0174	glutamine synthetase
A3858_04575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3858_04600	COG0772	Belongs to the SEDS family
A3858_04605	COG0768	penicillin binding
A3858_04630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3858_04655	COG0655	NAD(P)H dehydrogenase (quinone) activity
A3858_04685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3858_04705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3858_04710	COG0259	pyridoxamine-phosphate oxidase activity
A3858_04810	COG2188	Transcriptional regulator
A3858_04815	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_04820	COG0235	Class ii aldolase
A3858_04830	COG1129	ABC transporter
A3858_04835	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_04840	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_04850	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_04870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A3858_04875	COG0156	8-amino-7-oxononanoate synthase activity
A3858_04880	COG1063	alcohol dehydrogenase
A3858_04885	COG2124	cytochrome p450
A3858_04895	COG0753	catalase activity
A3858_04905	COG2094	Belongs to the DNA glycosylase MPG family
A3858_04960	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3858_04990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3858_04995	COG1177	transmembrane transport
A3858_05000	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_05005	COG3842	ATPase activity
A3858_05015	COG4206	TonB-dependent receptor
A3858_05025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3858_05030	COG1120	ATPase activity
A3858_05040	COG0784	Response regulator, receiver
A3858_05040	COG5002	protein histidine kinase activity
A3858_05050	COG0564	pseudouridine synthase activity
A3858_05055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3858_05070	COG1793	dna ligase
A3858_05070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3858_05080	COG2308	Evidence 4 Homologs of previously reported genes of
A3858_05135	COG1329	Transcriptional regulator
A3858_05140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3858_05145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3858_05160	COG2968	Membrane
A3858_05165	COG2873	o-acetylhomoserine
A3858_05175	COG0745	RESPONSE REGULATOR receiver
A3858_05180	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A3858_05195	COG0745	RESPONSE REGULATOR receiver
A3858_05205	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A3858_05220	COG0840	transmembrane signaling receptor activity
A3858_05225	COG0745	RESPONSE REGULATOR receiver
A3858_05235	COG0366	Alpha amylase catalytic
A3858_05245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A3858_05255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A3858_05270	COG4221	oxidoreductase activity
A3858_05275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3858_05295	COG1127	ABC transporter
A3858_05300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A3858_05305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3858_05320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3858_05325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3858_05340	COG4695	Portal protein
A3858_05420	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3858_05425	COG0022	dehydrogenase e1 component
A3858_05425	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3858_05430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A3858_05435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A3858_05440	COG1830	Aldolase
A3858_05445	COG0126	phosphoglycerate kinase activity
A3858_05450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A3858_05455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A3858_05460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A3858_05465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A3858_05485	COG0697	spore germination
A3858_05495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3858_05530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3858_05535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3858_05540	COG0546	phosphoglycolate phosphatase activity
A3858_05550	COG1960	acyl-CoA dehydrogenase activity
A3858_05555	COG3047	cAMP biosynthetic process
A3858_05560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3858_05575	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A3858_05595	COG0649	NAD binding
A3858_05630	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3858_05685	COG0513	Belongs to the DEAD box helicase family
A3858_05695	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_05700	COG3842	ATPase activity
A3858_05705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A3858_05715	COG0805	protein transport
A3858_05725	COG0739	heme binding
A3858_05725	COG1388	LysM domain
A3858_05735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A3858_05755	COG2273	Hydrolase Family 16
A3858_05760	COG1215	transferase activity, transferring glycosyl groups
A3858_05765	COG1215	transferase activity, transferring glycosyl groups
A3858_05795	COG1132	(ABC) transporter
A3858_05805	COG0489	protein tyrosine kinase activity
A3858_05805	COG3206	protein involved in exopolysaccharide biosynthesis
A3858_05815	COG1215	transferase activity, transferring glycosyl groups
A3858_05820	COG0438	transferase activity, transferring glycosyl groups
A3858_05830	COG1091	dTDP-4-dehydrorhamnose reductase activity
A3858_05845	COG0693	protein deglycase activity
A3858_05850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3858_05875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A3858_05895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3858_05925	COG1131	(ABC) transporter
A3858_05960	COG0784	Response regulator, receiver
A3858_05960	COG2198	Histidine kinase
A3858_05960	COG2205	protein histidine kinase activity
A3858_05975	COG1116	anion transmembrane transporter activity
A3858_05985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3858_05990	COG0745	RESPONSE REGULATOR receiver
A3858_05995	COG0704	Plays a role in the regulation of phosphate uptake
A3858_06000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3858_06005	COG0581	inorganic phosphate transmembrane transporter activity
A3858_06010	COG0573	inorganic phosphate transmembrane transporter activity
A3858_06035	COG0598	Magnesium transport protein CorA
A3858_06040	COG0717	Belongs to the dCTP deaminase family
A3858_06060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3858_06065	COG0416	fatty acid biosynthetic process
A3858_06085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3858_06095	COG0482	sulfurtransferase activity
A3858_06105	COG0745	RESPONSE REGULATOR receiver
A3858_06110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3858_06115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3858_06125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3858_06130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3858_06135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A3858_06140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3858_06145	COG5425	PFAM Usg family protein
A3858_06155	COG1138	Cytochrome C-type biogenesis protein
A3858_06160	COG3088	subunit of a heme lyase
A3858_06165	COG1024	Enoyl-CoA hydratase
A3858_06170	COG0440	acetolactate synthase activity
A3858_06175	COG0028	Belongs to the TPP enzyme family
A3858_06185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A3858_06205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A3858_06220	COG0129	dihydroxy-acid dehydratase activity
A3858_06260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A3858_06265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3858_06280	COG0316	Belongs to the HesB IscA family
A3858_06290	COG1295	ribonuclease BN
A3858_06300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3858_06315	COG0395	ABC-type sugar transport system, permease component
A3858_06325	COG3842	ATPase activity
A3858_06400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A3858_06415	COG4235	cytochrome complex assembly
A3858_06420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_06435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3858_06435	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3858_06445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3858_06445	COG2755	lipolytic protein G-D-S-L family
A3858_06455	COG1611	Belongs to the LOG family
A3858_06465	COG5265	(ABC) transporter
A3858_06490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3858_06495	COG0601	transmembrane transport
A3858_06505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A3858_06510	COG0528	UMP kinase activity
A3858_06515	COG0233	cytoplasmic translational termination
A3858_06520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3858_06525	COG0575	Belongs to the CDS family
A3858_06530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A3858_06535	COG0750	zinc metalloprotease
A3858_06540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3858_06555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3858_06560	COG3494	Protein of unknown function (DUF1009)
A3858_06565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3858_06595	COG0215	cysteine-tRNA ligase activity
A3858_06600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3858_06615	COG2814	Major facilitator Superfamily
A3858_06620	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3858_06645	COG0431	NADPH-dependent FMN reductase
A3858_06655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A3858_06665	COG0166	Belongs to the GPI family
A3858_06670	COG0251	oxidation-reduction process
A3858_06675	COG2897	thiosulfate sulfurtransferase activity
A3858_06680	COG2391	methyltransferase activity
A3858_06710	COG0438	transferase activity, transferring glycosyl groups
A3858_06730	COG0582	viral genome integration into host DNA
A3858_06835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A3858_06845	COG0248	Ppx GppA phosphatase
A3858_06850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A3858_06855	COG3108	Peptidase M15
A3858_06865	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3858_06870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3858_06910	COG2010	Cytochrome c
A3858_06915	COG3909	cytochrome
A3858_06925	COG2867	negative regulation of translational initiation
A3858_06930	COG2801	Transposase and inactivated derivatives
A3858_06950	COG0052	Belongs to the universal ribosomal protein uS2 family
A3858_06960	COG2313	pseudouridylate synthase activity
A3858_06965	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_06970	COG4166	transmembrane transport
A3858_06990	COG1309	transcriptional regulator
A3858_06995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A3858_07000	COG2814	Major facilitator Superfamily
A3858_07005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3858_07025	COG2084	Dehydrogenase
A3858_07035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3858_07050	COG0569	domain protein
A3858_07055	COG2204	response regulator
A3858_07060	COG5000	phosphorelay sensor kinase activity
A3858_07065	COG2204	response regulator
A3858_07070	COG3852	Histidine kinase
A3858_07075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3858_07080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A3858_07095	COG1546	Belongs to the CinA family
A3858_07095	COG1058	Belongs to the CinA family
A3858_07100	COG2081	HI0933 family
A3858_07155	COG2099	Precorrin-6x reductase
A3858_07170	COG2875	Belongs to the precorrin methyltransferase family
A3858_07175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A3858_07175	COG1648	precorrin-2 dehydrogenase activity
A3858_07185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A3858_07190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3858_07200	COG4974	Belongs to the 'phage' integrase family
A3858_07205	COG4536	flavin adenine dinucleotide binding
A3858_07220	COG5598	trimethylamine methyltransferase
A3858_07235	COG1127	ABC transporter
A3858_07240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A3858_07260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3858_07265	COG1902	pentaerythritol trinitrate reductase activity
A3858_07270	COG0343	queuine tRNA-ribosyltransferase activity
A3858_07275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3858_07305	COG0459	protein refolding
A3858_07310	COG0489	protein tyrosine kinase activity
A3858_07310	COG2151	metal-sulfur cluster biosynthetic enzyme
A3858_07330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3858_07365	COG0516	GMP reductase activity
A3858_07365	COG0517	IMP dehydrogenase activity
A3858_07375	COG3842	ATPase activity
A3858_07380	COG0395	ABC-type sugar transport system, permease component
A3858_07385	COG1175	transmembrane transport
A3858_07390	COG1653	transport
A3858_07395	COG2723	6-phospho-beta-galactosidase activity
A3858_07400	COG0837	glucose binding
A3858_07425	COG0784	Response regulator, receiver
A3858_07425	COG2198	Histidine kinase
A3858_07425	COG2205	protein histidine kinase activity
A3858_07440	COG0033	Phosphoglucomutase
A3858_07450	COG0297	glycogen (starch) synthase activity
A3858_07460	COG0058	SHG alpha-glucan phosphorylase activity
A3858_07465	COG1959	2 iron, 2 sulfur cluster binding
A3858_07490	COG0488	(ABC) transporter
A3858_07495	COG2095	MarC family integral membrane protein
A3858_07500	COG3577	Aspartyl protease
A3858_07510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A3858_07515	COG0795	lipopolysaccharide-transporting ATPase activity
A3858_07530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3858_07535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A3858_07540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3858_07550	COG2890	protein-(glutamine-N5) methyltransferase activity
A3858_07555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A3858_07565	COG0010	Belongs to the arginase family
A3858_07575	COG3956	TIGRFAM MazG family protein
A3858_07580	COG1840	ABC-type Fe3 transport system, periplasmic component
A3858_07590	COG5002	protein histidine kinase activity
A3858_07600	COG0626	cystathionine gamma-synthase activity
A3858_07610	COG0194	GDP metabolic process
A3858_07615	COG1561	YicC-like family, N-terminal region
A3858_07625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A3858_07635	COG0683	leucine binding
A3858_07650	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3858_07680	COG2188	Transcriptional regulator
A3858_07690	COG1228	amidohydrolase
A3858_07695	COG2986	histidine ammonia-lyase
A3858_07700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A3858_07705	COG1796	DNA polymerase
A3858_07705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A3858_07710	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A3858_07725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A3858_07730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A3858_07745	COG0018	arginyl-trna synthetase
A3858_07765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A3858_07770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A3858_07780	COG0583	DNA-binding transcription factor activity
A3858_07785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3858_07795	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A3858_07810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A3858_07820	COG2354	Protein conserved in bacteria
A3858_07860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A3858_07870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3858_07880	COG2814	Major facilitator Superfamily
A3858_07885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A3858_07895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3858_07900	COG1196	nuclear chromosome segregation
A3858_07900	COG0741	lytic transglycosylase activity
A3858_07900	COG0739	heme binding
A3858_07915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A3858_07920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A3858_07925	COG0860	N-Acetylmuramoyl-L-alanine amidase
A3858_07940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A3858_07950	COG0156	8-amino-7-oxononanoate synthase activity
A3858_07980	COG1741	Belongs to the pirin family
A3858_08015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3858_08025	COG0519	Catalyzes the synthesis of GMP from XMP
A3858_08025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3858_08060	COG2326	polyphosphate kinase activity
A3858_08070	COG3842	ATPase activity
A3858_08080	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_08085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3858_08115	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A3858_08120	COG0673	inositol 2-dehydrogenase activity
A3858_08135	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_08140	COG0427	acetyl-CoA hydrolase
A3858_08145	COG5001	Diguanylate cyclase
A3858_08230	COG0643	Histidine kinase
A3858_08230	COG2198	Histidine kinase
A3858_08235	COG2201	protein-glutamate methylesterase activity
A3858_08240	COG0840	transmembrane signaling receptor activity
A3858_08245	COG1192	Involved in chromosome partitioning
A3858_08250	COG0835	chemotaxis
A3858_08255	COG2201	protein-glutamate methylesterase activity
A3858_08265	COG2198	Histidine kinase
A3858_08265	COG0643	Histidine kinase
A3858_08275	COG2204	response regulator
A3858_08280	COG1677	Flagellar hook-basal body complex protein FliE
A3858_08340	COG1987	bacterial-type flagellum assembly
A3858_08345	COG1684	flagellar biosynthetic protein fliR
A3858_08350	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3858_08375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A3858_08375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A3858_08380	COG3604	Transcriptional regulator
A3858_08395	COG1256	bacterial-type flagellum assembly
A3858_08405	COG1706	bacterial-type flagellum-dependent cell motility
A3858_08415	COG4786	Flagellar basal body rod
A3858_08420	COG4786	Flagellar basal body rod
A3858_08425	COG1749	Flagellar hook protein flgE
A3858_08430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A3858_08435	COG1558	bacterial-type flagellum-dependent cell motility
A3858_08440	COG1815	bacterial-type flagellum-dependent cell motility
A3858_08465	COG3685	Protein conserved in bacteria
A3858_08470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3858_08475	COG2390	Transcriptional regulator
A3858_08485	COG1175	transmembrane transport
A3858_08515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3858_08520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3858_08530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3858_08535	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3858_08540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3858_08540	COG0649	NAD binding
A3858_08555	COG1034	ATP synthesis coupled electron transport
A3858_08560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3858_08565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3858_08575	COG0713	ATP synthesis coupled electron transport
A3858_08590	COG1007	ATP synthesis coupled electron transport
A3858_08595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3858_08605	COG2863	cytochrome
A3858_08615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3858_08625	COG0671	phosphoesterase, PA-phosphatase related
A3858_08645	COG3916	Acyl-homoserine-lactone synthase
A3858_08655	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3858_08665	COG2943	transferase activity, transferring hexosyl groups
A3858_08680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3858_08685	COG2011	ABC-type metal ion transport system permease component
A3858_08690	COG1464	Belongs to the NlpA lipoprotein family
A3858_08750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3858_08750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3858_08770	COG3920	Histidine kinase
A3858_08775	COG0784	Response regulator, receiver
A3858_08780	COG2205	protein histidine kinase activity
A3858_08830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3858_08835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3858_08855	COG3750	Belongs to the UPF0335 family
A3858_08880	COG5002	protein histidine kinase activity
A3858_08890	COG0745	RESPONSE REGULATOR receiver
A3858_08895	COG3800	Transcriptional regulator
A3858_08895	COG1396	sequence-specific DNA binding
A3858_08905	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_08910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3858_08915	COG0129	dihydroxy-acid dehydratase activity
A3858_08920	COG0277	FAD linked oxidase domain protein
A3858_08925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3858_08930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3858_08935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3858_08955	COG1309	transcriptional regulator
A3858_08960	COG1309	transcriptional regulator
A3858_08985	COG0439	Biotin carboxylase
A3858_08990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A3858_09010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A3858_09030	COG4135	transport system, permease component
A3858_09035	COG4136	ATPase activity
A3858_09040	COG2340	Cysteine-rich secretory protein family
A3858_09180	COG1755	Isoprenylcysteine carboxyl methyltransferase
A3858_09215	COG0840	transmembrane signaling receptor activity
A3858_09225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3858_09245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A3858_09265	COG1376	ErfK ybiS ycfS ynhG family protein
A3858_09270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3858_09275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3858_09290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A3858_09310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3858_09315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_09320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A3858_09355	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3858_09360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3858_09365	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A3858_09375	COG0500	methyltransferase
A3858_09380	COG0142	geranyltranstransferase activity
A3858_09385	COG1233	COG1233 Phytoene dehydrogenase and related
A3858_09390	COG5621	secreted hydrolase
A3858_09400	COG1562	ergosterol biosynthetic process
A3858_09405	COG1233	COG1233 Phytoene dehydrogenase and related
A3858_09415	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A3858_09420	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A3858_09435	COG0644	oxidoreductase
A3858_09440	COG2211	Major facilitator Superfamily
A3858_09445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3858_09450	COG1719	4-vinyl reductase, 4VR
A3858_09455	COG1032	radical SAM domain protein
A3858_09475	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3858_09480	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3858_09485	COG1429	ligase activity, forming nitrogen-metal bonds
A3858_09505	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A3858_09525	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A3858_09535	COG3474	cytochrome
A3858_09550	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_09565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A3858_09570	COG0830	nickel cation binding
A3858_09575	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A3858_09585	COG0804	urea catabolic process
A3858_09610	COG0829	nickel cation binding
A3858_09635	COG2814	Major facilitator Superfamily
A3858_09640	COG2197	response regulator
A3858_09645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3858_09670	COG0714	Associated with various cellular activities
A3858_09675	COG3256	nitric oxide reductase
A3858_09680	COG2010	Cytochrome c
A3858_09745	COG2264	protein methyltransferase activity
A3858_09755	COG0402	S-adenosylhomocysteine deaminase activity
A3858_09765	COG4603	Belongs to the binding-protein-dependent transport system permease family
A3858_09795	COG3842	ATPase activity
A3858_09815	COG0587	DNA-directed DNA polymerase activity
A3858_09830	COG0330	HflC and HflK could
A3858_09835	COG0330	HflC and HflK could
A3858_09845	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3858_09850	COG1760	l-serine dehydratase
A3858_09855	COG0697	spore germination
A3858_09875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3858_09885	COG0504	CTP synthase activity
A3858_09910	COG4215	(ABC) transporter
A3858_09915	COG4160	amino acid transport
A3858_09920	COG0174	glutamine synthetase
A3858_09925	COG0519	Catalyzes the synthesis of GMP from XMP
A3858_09930	COG0174	glutamine synthetase
A3858_09935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_09940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3858_09955	COG3243	poly(R)-hydroxyalkanoic acid synthase
A3858_09970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3858_09975	COG1278	Cold shock
A3858_09995	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A3858_10000	COG0346	lactoylglutathione lyase activity
A3858_10005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3858_10005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3858_10020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3858_10025	COG0358	DNA primase activity
A3858_10030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3858_10070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A3858_10080	COG3706	GGDEF domain
A3858_10085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3858_10110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A3858_10115	COG0546	phosphoglycolate phosphatase activity
A3858_10125	COG3706	GGDEF domain
A3858_10175	COG0667	Aldo Keto reductase
A3858_10185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3858_10220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3858_10235	COG0719	Fe-S assembly protein
A3858_10240	COG0396	ATPase activity
A3858_10250	COG0719	Fe-S assembly protein
A3858_10265	COG2945	thiolester hydrolase activity
A3858_10275	COG0538	isocitrate dehydrogenase activity
A3858_10290	COG0121	glutamine amidotransferase
A3858_10300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3858_10320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3858_10320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3858_10335	COG5642	Protein of unknown function (DUF2384)
A3858_10350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3858_10355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3858_10375	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A3858_10385	COG0579	oxidoreductase
A3858_10405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3858_10410	COG3909	cytochrome
A3858_10420	COG0235	Class ii aldolase
A3858_10440	COG0246	Mannitol dehydrogenase
A3858_10445	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_10455	COG1917	Cupin 2, conserved barrel domain protein
A3858_10470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3858_10475	COG1904	glucuronate isomerase
A3858_10480	COG1802	Transcriptional regulator
A3858_10490	COG4191	Histidine kinase
A3858_10510	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A3858_10560	COG0375	protein maturation
A3858_10595	COG2197	response regulator
A3858_10600	COG4191	Histidine kinase
A3858_10610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3858_10635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3858_10645	COG1063	alcohol dehydrogenase
A3858_10650	COG0673	inositol 2-dehydrogenase activity
A3858_10655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A3858_10665	COG1272	protein, Hemolysin III
A3858_10735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3858_10740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3858_10770	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3858_10795	COG1686	Belongs to the peptidase S11 family
A3858_10810	COG2076	Multidrug Resistance protein
A3858_10820	COG0501	Belongs to the peptidase M48B family
A3858_10830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A3858_10845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3858_10865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A3858_10875	COG1183	phosphatidylcholine synthase activity
A3858_10885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3858_10895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A3858_10900	COG3768	UPF0283 membrane protein
A3858_10905	COG3106	COG3106 Predicted ATPase
A3858_10910	COG0101	tRNA pseudouridine synthase activity
A3858_10915	COG2176	DNA-directed DNA polymerase activity
A3858_10915	COG5002	protein histidine kinase activity
A3858_10920	COG0745	RESPONSE REGULATOR receiver
A3858_10930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A3858_10935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3858_10950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3858_10975	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3858_10980	COG1764	response to oxidative stress
A3858_10990	COG0488	(ABC) transporter
A3858_11010	COG1278	Cold shock
A3858_11020	COG3119	arylsulfatase activity
A3858_11035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3858_11040	COG0756	dUTP diphosphatase activity
A3858_11045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A3858_11055	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3858_11075	COG1203	CRISPR-associated helicase, Cas3
A3858_11080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3858_11085	COG1595	DNA-templated transcription, initiation
A3858_11095	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_11100	COG1733	regulation of RNA biosynthetic process
A3858_11135	COG0514	ATP-dependent DNA helicase (RecQ)
A3858_11145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A3858_11150	COG1530	ribonuclease E activity
A3858_11155	COG0424	maF-like protein
A3858_11165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3858_11165	COG3153	acetyltransferase
A3858_11180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3858_11185	COG5328	Belongs to the UPF0262 family
A3858_11200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A3858_11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_11250	COG1396	sequence-specific DNA binding
A3858_11265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3858_11270	COG1116	anion transmembrane transporter activity
A3858_11275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3858_11280	COG0351	phosphomethylpyrimidine kinase
A3858_11285	COG0352	thiamine-phosphate diphosphorylase activity
A3858_11290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A3858_11295	COG1196	nuclear chromosome segregation
A3858_11295	COG0741	lytic transglycosylase activity
A3858_11295	COG0739	heme binding
A3858_11305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3858_11310	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3858_11320	COG0217	transcriptional regulatory protein
A3858_11325	COG3273	potassium ion transport
A3858_11325	COG0471	metal ion transport
A3858_11330	COG1692	metallophosphoesterase
A3858_11335	COG1201	RNA secondary structure unwinding
A3858_11350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A3858_11370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3858_11375	COG0037	tRNA processing
A3858_11385	COG2885	chlorophyll binding
A3858_11400	COG0848	biopolymer transport protein
A3858_11410	COG0824	Thioesterase
A3858_11425	COG0084	hydrolase, TatD family'
A3858_11450	COG0181	hydroxymethylbilane synthase activity
A3858_11455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A3858_11465	COG0408	coproporphyrinogen oxidase activity
A3858_11475	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_11485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A3858_11495	COG1686	Belongs to the peptidase S11 family
A3858_11515	COG0348	domain, Protein
A3858_11520	COG2010	Cytochrome c
A3858_11545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3858_11550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3858_11555	COG0438	transferase activity, transferring glycosyl groups
A3858_11560	COG4172	Belongs to the ABC transporter superfamily
A3858_11565	COG4239	(ABC) transporter, permease
A3858_11570	COG4174	ABC transporter (Permease)
A3858_11615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A3858_11655	COG0688	phosphatidylethanolamine metabolic process
A3858_11660	COG1183	phosphatidylcholine synthase activity
A3858_11670	COG1522	sequence-specific DNA binding
A3858_11675	COG0686	Belongs to the AlaDH PNT family
A3858_11680	COG1970	mechanosensitive ion channel activity
A3858_11685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3858_11690	COG0165	Argininosuccinate lyase
A3858_11710	COG0019	diaminopimelate decarboxylase activity
A3858_11725	COG2884	Cell division ATP-binding protein ftsE
A3858_11745	COG1763	Mo-molybdopterin cofactor biosynthetic process
A3858_11750	COG0746	molybdenum cofactor guanylyltransferase activity
A3858_11780	COG1960	acyl-CoA dehydrogenase activity
A3858_11785	COG0009	L-threonylcarbamoyladenylate synthase
A3858_11790	COG2818	Glycosylase
A3858_11815	COG0142	geranyltranstransferase activity
A3858_11850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3858_11855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A3858_11860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3858_11860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3858_11880	COG1596	polysaccharide export
A3858_11885	COG1846	Transcriptional regulator
A3858_11905	COG0534	Mate efflux family protein
A3858_11915	COG2326	polyphosphate kinase activity
A3858_11930	COG0187	DNA topoisomerase II activity
A3858_11935	COG1312	Catalyzes the dehydration of D-mannonate
A3858_11950	COG1136	(ABC) transporter
A3858_11955	COG4591	ABC-type transport system involved in lipoprotein release permease component
A3858_11960	COG0442	prolyl-tRNA aminoacylation
A3858_11965	COG0628	permease
A3858_11975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A3858_11980	COG0248	Ppx GppA phosphatase
A3858_11990	COG1247	-acetyltransferase
A3858_11995	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A3858_12020	COG0535	radical SAM domain protein
A3858_12030	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A3858_12035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3858_12055	COG1492	cobalamin metabolic process
A3858_12065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3858_12075	COG1234	tRNA 3'-trailer cleavage
A3858_12080	COG1872	DUF167
A3858_12095	COG4608	Belongs to the ABC transporter superfamily
A3858_12100	COG0444	Belongs to the ABC transporter superfamily
A3858_12110	COG0601	transmembrane transport
A3858_12115	COG0747	negative chemotaxis
A3858_12165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A3858_12170	COG0513	Belongs to the DEAD box helicase family
A3858_12185	COG0596	Alpha beta hydrolase
A3858_12195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3858_12200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3858_12205	COG0193	aminoacyl-tRNA hydrolase activity
A3858_12225	COG1304	FMN binding
A3858_12240	COG0012	GTP binding
A3858_12245	COG0662	Cupin 2, conserved barrel domain protein
A3858_12245	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A3858_12280	COG0495	leucyl-tRNA aminoacylation
A3858_12315	COG0745	RESPONSE REGULATOR receiver
A3858_12325	COG1309	transcriptional regulator
A3858_12335	COG0679	Auxin Efflux Carrier
A3858_12340	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A3858_12345	COG1671	Belongs to the UPF0178 family
A3858_12350	COG2423	ornithine cyclodeaminase activity
A3858_12365	COG4106	trans-aconitate 2-methyltransferase activity
A3858_12375	COG0697	spore germination
A3858_12380	COG0473	3-isopropylmalate dehydrogenase activity
A3858_12405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3858_12415	COG0799	negative regulation of ribosome biogenesis
A3858_12420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A3858_12445	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3858_12450	COG0242	peptide deformylase activity
A3858_12455	COG0242	peptide deformylase activity
A3858_12460	COG0242	peptide deformylase activity
A3858_12465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3858_12485	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A3858_12485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_12495	COG0741	lytic transglycosylase activity
A3858_12500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3858_12510	COG2897	thiosulfate sulfurtransferase activity
A3858_12520	COG0004	ammonium transporteR
A3858_12525	COG0347	Belongs to the P(II) protein family
A3858_12540	COG2853	Lipoprotein
A3858_12550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3858_12575	COG2154	pterin-4-alpha-carbinolamine dehydratase
A3858_12580	COG0678	peroxiredoxin activity
A3858_12590	COG0742	ribosomal rna small subunit methyltransferase
A3858_12595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3858_12605	COG0803	Belongs to the bacterial solute-binding protein 9 family
A3858_12610	COG1121	(ABC) transporter
A3858_12615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3858_12620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3858_12655	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_12665	COG0312	modulator of DNA gyrase
A3858_12680	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_12690	COG0848	biopolymer transport protein
A3858_12720	COG0583	DNA-binding transcription factor activity
A3858_12730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A3858_12735	COG0285	dihydrofolate synthase activity
A3858_12740	COG0494	nUDIX hydrolase
A3858_12745	COG0793	Belongs to the peptidase S41A family
A3858_12755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A3858_12760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3858_12765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A3858_12795	COG1116	anion transmembrane transporter activity
A3858_12805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3858_12835	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A3858_12840	COG1877	trehalose-phosphatase activity
A3858_12845	COG4187	Peptidase family M20/M25/M40
A3858_12865	COG0737	Belongs to the 5'-nucleotidase family
A3858_12875	COG0167	dihydroorotate dehydrogenase activity
A3858_12910	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3858_12915	COG0567	Dehydrogenase, E1 component
A3858_12940	COG2301	Belongs to the HpcH HpaI aldolase family
A3858_12955	COG2030	dehydratase
A3858_12995	COG1802	Transcriptional regulator
A3858_13020	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A3858_13030	COG1072	(Pantothenic acid kinase))
A3858_13055	COG2111	Na H antiporter
A3858_13055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3858_13060	COG1006	Multisubunit Na H antiporter MnhC subunit
A3858_13065	COG0651	ATP synthesis coupled electron transport
A3858_13070	COG1863	multisubunit Na H antiporter MnhE subunit
A3858_13075	COG2212	antiporter activity
A3858_13080	COG1320	monovalent cation:proton antiporter activity
A3858_13090	COG1678	Uncharacterized ACR, COG1678
A3858_13100	COG1573	uracil-dna glycosylase
A3858_13135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3858_13160	COG1253	flavin adenine dinucleotide binding
A3858_13170	COG2304	oxidoreductase activity
A3858_13175	COG0071	Belongs to the small heat shock protein (HSP20) family
A3858_13185	COG0247	lactate metabolic process
A3858_13190	COG0277	FAD linked oxidase domain protein
A3858_13195	COG0277	FAD linked oxidase domain protein
A3858_13220	COG0714	Associated with various cellular activities
A3858_13240	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3858_13240	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3858_13250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3858_13255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3858_13260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3858_13265	COG2885	chlorophyll binding
A3858_13270	COG2186	Transcriptional regulator
A3858_13275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A3858_13285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A3858_13300	COG0640	Transcriptional regulator
A3858_13305	COG0318	PFAM AMP-dependent synthetase and ligase
A3858_13310	COG1192	Involved in chromosome partitioning
A3858_13325	COG0336	Belongs to the RNA methyltransferase TrmD family
A3858_13335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A3858_13365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3858_13385	COG3852	Histidine kinase
A3858_13405	COG0594	ribonuclease P activity
A3858_13415	COG0037	tRNA processing
A3858_13425	COG0706	membrane insertase activity
A3858_13435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3858_13440	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_13460	COG0314	molybdopterin synthase activity
A3858_13470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3858_13475	COG0322	excinuclease ABC activity
A3858_13480	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_13490	COG0616	signal peptide processing
A3858_13490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A3858_13510	COG3383	formate dehydrogenase (NAD+) activity
A3858_13515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A3858_13530	COG0297	glycogen (starch) synthase activity
A3858_13530	COG0438	transferase activity, transferring glycosyl groups
A3858_13535	COG0745	RESPONSE REGULATOR receiver
A3858_13550	COG4221	oxidoreductase activity
A3858_13575	COG1595	DNA-templated transcription, initiation
A3858_13580	COG3806	Anti-sigma factor
A3858_13585	COG1322	Protein conserved in bacteria
A3858_13590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A3858_13595	COG0612	Peptidase, M16
A3858_13600	COG0612	Peptidase, M16
A3858_13610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A3858_13635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A3858_13640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A3858_13650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3858_13690	COG0438	transferase activity, transferring glycosyl groups
A3858_13725	COG0587	DNA-directed DNA polymerase activity
A3858_13730	COG2951	lytic endotransglycosylase activity
A3858_13735	COG0557	exoribonuclease II activity
A3858_13745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3858_13755	COG2323	membrane
A3858_13760	COG2171	N-acyltransferase activity
A3858_13775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A3858_13780	COG0142	geranyltranstransferase activity
A3858_13785	COG1722	exodeoxyribonuclease VII activity
A3858_13790	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3858_13795	COG0745	RESPONSE REGULATOR receiver
A3858_13800	COG1846	Transcriptional regulator
A3858_13805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3858_13815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3858_13825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3858_13885	COG1137	ATPase activity
A3858_13890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A3858_13895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3858_13905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A3858_13910	COG1218	3'(2'),5'-bisphosphate nucleotidase
A3858_13915	COG0779	Required for maturation of 30S ribosomal subunits
A3858_13930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3858_13935	COG0494	nUDIX hydrolase
A3858_13940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A3858_13945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3858_13950	COG0653	protein targeting
A3858_13960	COG2003	Belongs to the UPF0758 family
A3858_13965	COG0484	heat shock protein binding
A3858_13970	COG0443	Heat shock 70 kDa protein
A3858_13980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A3858_13985	COG2115	Belongs to the xylose isomerase family
A3858_13990	COG1070	Carbohydrate kinase
A3858_13995	COG1129	ABC transporter
A3858_14000	COG4214	carbohydrate transport
A3858_14005	COG4213	ABC transporter substrate-binding protein
A3858_14010	COG1940	carbohydrate kinase activity
A3858_14015	COG0729	surface antigen
A3858_14020	COG2911	Protein conserved in bacteria
A3858_14025	COG1295	ribonuclease BN
A3858_14040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3858_14050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3858_14065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3858_14070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A3858_14075	COG1040	competence protein
A3858_14100	COG3034	peptidoglycan biosynthetic process
A3858_14105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3858_14110	COG1132	(ABC) transporter
A3858_14115	COG1132	(ABC) transporter
A3858_14120	COG0617	tRNA 3'-terminal CCA addition
A3858_14125	COG0494	nUDIX hydrolase
A3858_14130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A3858_14140	COG0745	RESPONSE REGULATOR receiver
A3858_14175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3858_14175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3858_14180	COG0281	malic enzyme
A3858_14180	COG0280	phosphate acetyltransferase
A3858_14190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A3858_14195	COG1420	regulation of RNA biosynthetic process
A3858_14205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3858_14210	COG0251	oxidation-reduction process
A3858_14215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3858_14220	COG2832	Protein of unknown function (DUF454)
A3858_14225	COG1475	DNA binding
A3858_14230	COG1192	Involved in chromosome partitioning
A3858_14235	COG0357	Ribosomal RNA small subunit methyltransferase G
A3858_14240	COG0445	tRNA wobble uridine modification
A3858_14245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A3858_14250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A3858_14260	COG0424	maF-like protein
A3858_14265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3858_14270	COG0237	dephospho-CoA kinase activity
A3858_14275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3858_14300	COG2840	Smr protein MutS2
A3858_14310	COG1609	Transcriptional regulator
A3858_14320	COG0673	inositol 2-dehydrogenase activity
A3858_14325	COG1129	ABC transporter
A3858_14330	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_14335	COG1879	ABC-type sugar transport system periplasmic component
A3858_14365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A3858_14375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3858_14380	COG3243	poly(R)-hydroxyalkanoic acid synthase
A3858_14385	COG2267	carboxylic ester hydrolase activity
A3858_14400	COG2200	EAL domain
A3858_14415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A3858_14425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A3858_14430	COG2205	protein histidine kinase activity
A3858_14435	COG0745	RESPONSE REGULATOR receiver
A3858_14440	COG3237	CsbD-like
A3858_14460	COG0784	Response regulator, receiver
A3858_14470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3858_14485	COG0546	phosphoglycolate phosphatase activity
A3858_14520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A3858_14530	COG0410	ABC transporter
A3858_14560	COG1012	belongs to the aldehyde dehydrogenase family
A3858_14570	COG0022	dehydrogenase e1 component
A3858_14575	COG1960	acyl-CoA dehydrogenase activity
A3858_14580	COG0583	DNA-binding transcription factor activity
A3858_14585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A3858_14615	COG1749	Flagellar hook protein flgE
A3858_14630	COG1706	bacterial-type flagellum-dependent cell motility
A3858_14635	COG0784	Response regulator, receiver
A3858_14635	COG4191	Histidine kinase
A3858_14645	COG1338	Plays a role in the flagellum-specific transport system
A3858_14650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A3858_14660	COG1766	The M ring may be actively involved in energy transduction
A3858_14680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A3858_14695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3858_14705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3858_14720	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A3858_14730	COG4786	Flagellar basal body rod
A3858_14735	COG4786	Flagellar basal body rod
A3858_14740	COG1987	bacterial-type flagellum assembly
A3858_14745	COG1677	Flagellar hook-basal body complex protein FliE
A3858_14750	COG1558	bacterial-type flagellum-dependent cell motility
A3858_14755	COG1815	bacterial-type flagellum-dependent cell motility
A3858_14760	COG1157	protein secretion by the type III secretion system
A3858_14785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A3858_14800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A3858_14820	COG0592	DNA-directed DNA polymerase activity
A3858_14825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3858_14835	COG0187	DNA topoisomerase II activity
A3858_14840	COG4325	translation initiation factor activity
A3858_14845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A3858_14850	COG0560	Phosphoserine phosphatase
A3858_14855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A3858_14860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3858_14870	COG0183	Belongs to the thiolase family
A3858_14875	COG4953	penicillin-binding protein 1C
A3858_14880	COG2373	Large extracellular alpha-helical protein
A3858_14885	COG0784	Response regulator, receiver
A3858_14885	COG2205	protein histidine kinase activity
A3858_14885	COG5002	protein histidine kinase activity
A3858_14890	COG3022	response to hydroperoxide
A3858_14895	COG0514	ATP-dependent DNA helicase (RecQ)
A3858_14915	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A3858_14925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A3858_14935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A3858_14940	COG1335	isochorismatase
A3858_14945	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_14950	COG3734	2-keto-3-deoxy-galactonokinase
A3858_14955	COG0366	Alpha amylase catalytic
A3858_14960	COG2271	Major facilitator Superfamily
A3858_14970	COG0438	transferase activity, transferring glycosyl groups
A3858_14985	COG0288	reversible hydration of carbon dioxide
A3858_14995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A3858_15000	COG0791	NLP P60 protein
A3858_15005	COG3214	Protein conserved in bacteria
A3858_15030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A3858_15045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A3858_15050	COG4143	(ABC) transporter
A3858_15060	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A3858_15080	COG0625	glutathione transferase activity
A3858_15105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3858_15125	COG0284	orotidine-5'-phosphate decarboxylase activity
A3858_15130	COG1940	carbohydrate kinase activity
A3858_15140	COG0542	response to heat
A3858_15145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A3858_15150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3858_15205	COG3609	addiction module antidote protein, CC2985 family
A3858_15250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A3858_15270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A3858_15275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A3858_15300	COG0352	thiamine-phosphate diphosphorylase activity
A3858_15315	COG1612	heme a metabolic process
A3858_15320	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3858_15350	COG1228	amidohydrolase
A3858_15400	COG4372	Transposase
A3858_15415	COG3246	L-lysine catabolic process to acetate
A3858_15425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3858_15430	COG1960	acyl-CoA dehydrogenase activity
A3858_15460	COG2249	NAD(P)H dehydrogenase (quinone) activity
A3858_15470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3858_15475	COG0348	domain, Protein
A3858_15480	COG0156	8-amino-7-oxononanoate synthase activity
A3858_15490	COG0601	transmembrane transport
A3858_15500	COG0444	Belongs to the ABC transporter superfamily
A3858_15515	COG2814	Major facilitator Superfamily
A3858_15530	COG1177	transmembrane transport
A3858_15535	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_15545	COG3842	ATPase activity
A3858_15565	COG3005	denitrification pathway
A3858_15580	COG0303	'Molybdopterin
A3858_15600	COG0346	lactoylglutathione lyase activity
A3858_15605	COG0400	carboxylic ester hydrolase activity
A3858_15625	COG3448	diguanylate cyclase activity
A3858_15625	COG4175	Glycine betaine
A3858_15630	COG4176	ABC-type proline glycine betaine transport system permease component
A3858_15655	COG0318	PFAM AMP-dependent synthetase and ligase
A3858_15660	COG1349	DNA-binding transcription factor activity
A3858_15670	COG2223	nitrite transmembrane transporter activity
A3858_15685	COG0431	NADPH-dependent FMN reductase
A3858_15715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3858_15720	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A3858_15725	COG3046	protein related to deoxyribodipyrimidine photolyase
A3858_15735	COG4607	ABC-type enterochelin transport system periplasmic component
A3858_15740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A3858_15745	COG1132	(ABC) transporter
A3858_15755	COG0840	transmembrane signaling receptor activity
A3858_15765	COG2194	sulfuric ester hydrolase activity
A3858_15775	COG0642	Histidine kinase
A3858_15780	COG0745	RESPONSE REGULATOR receiver
A3858_15790	COG2824	Alkylphosphonate utilization operon protein PhnA
A3858_15805	COG0670	Belongs to the BI1 family
A3858_15815	COG1595	DNA-templated transcription, initiation
A3858_15825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3858_15845	COG5001	Diguanylate cyclase
A3858_15855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A3858_15875	COG3920	Histidine kinase
A3858_15895	COG0840	transmembrane signaling receptor activity
A3858_15920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_15935	COG0628	permease
A3858_15945	COG3443	Belongs to the bacterial solute-binding protein 9 family
A3858_15970	COG0435	Glutathione S-transferase
A3858_15975	COG3384	dioxygenase
A3858_15990	COG0798	PFAM Bile acid sodium symporter
A3858_16005	COG3266	domain, Protein
A3858_16005	COG0515	serine threonine protein kinase
A3858_16010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3858_16025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3858_16050	COG4529	Protein conserved in bacteria
A3858_16055	COG3386	PFAM SMP-30 Gluconolaconase
A3858_16075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3858_16085	COG2855	membrane
A3858_16100	COG1053	succinate dehydrogenase
A3858_16115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A3858_16130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3858_16135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A3858_16140	COG0028	Belongs to the TPP enzyme family
A3858_16145	COG0583	DNA-binding transcription factor activity
A3858_16155	COG0842	Transport permease protein
A3858_16160	COG1129	ABC transporter
A3858_16160	COG0842	Transport permease protein
A3858_16165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3858_16170	COG0392	lysyltransferase activity
A3858_16195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3858_16200	COG1116	anion transmembrane transporter activity
A3858_16200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3858_16215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3858_16220	COG2084	Dehydrogenase
A3858_16225	COG0730	response to heat
A3858_16230	COG1953	Uracil, thiamine, allantoin
A3858_16240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3858_16250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3858_16265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3858_16270	COG1960	acyl-CoA dehydrogenase activity
A3858_16280	COG0183	Belongs to the thiolase family
A3858_16285	COG1797	cobyrinic acid a,c-diamide synthase activity
A3858_16300	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3858_16325	COG0426	domain, Protein
A3858_16335	COG2878	Part of a membrane complex involved in electron transport
A3858_16350	COG4659	FMN binding
A3858_16360	COG2914	Belongs to the UPF0125 (RnfH) family
A3858_16370	COG0443	Heat shock 70 kDa protein
A3858_16375	COG0667	Aldo Keto reductase
A3858_16380	COG2207	Transcriptional regulator
A3858_16395	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3858_16400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3858_16410	COG0310	cobalt ion transport
A3858_16430	COG1294	oxidase, subunit
A3858_16435	COG1271	oxidase subunit
A3858_16445	COG4717	serine-type aminopeptidase activity
A3858_16450	COG0420	3'-5' exonuclease activity
A3858_16455	COG0778	Nitroreductase
A3858_16470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3858_16475	COG4605	iron ion homeostasis
A3858_16480	COG4604	ABC transporter, ATP-binding protein
A3858_16485	COG4771	TonB-dependent receptor
A3858_16495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3858_16510	COG2951	lytic endotransglycosylase activity
A3858_16520	COG0747	negative chemotaxis
A3858_16525	COG0601	transmembrane transport
A3858_16530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3858_16540	COG4608	Belongs to the ABC transporter superfamily
A3858_16545	COG0346	lactoylglutathione lyase activity
A3858_16555	COG2205	protein histidine kinase activity
A3858_16580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A3858_16590	COG4172	Belongs to the ABC transporter superfamily
A3858_16600	COG0601	transmembrane transport
A3858_16615	COG0747	negative chemotaxis
A3858_16620	COG0601	transmembrane transport
A3858_16625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3858_16640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3858_16655	COG2010	Cytochrome c
A3858_16665	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A3858_16725	COG0673	inositol 2-dehydrogenase activity
A3858_16730	COG3962	Belongs to the TPP enzyme family
A3858_16740	COG3718	enzyme involved in inositol metabolism
A3858_16745	COG3842	ATPase activity
A3858_16750	COG0395	ABC-type sugar transport system, permease component
A3858_16755	COG1175	transmembrane transport
A3858_16760	COG1653	transport
A3858_16765	COG1283	sodium-dependent phosphate transmembrane transporter activity
A3858_16785	COG0410	ABC transporter
A3858_16790	COG0411	ABC transporter
A3858_16820	COG0800	Aldolase
A3858_16825	COG0745	RESPONSE REGULATOR receiver
A3858_16830	COG0840	transmembrane signaling receptor activity
A3858_16840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A3858_16860	COG0697	spore germination
A3858_16875	COG2801	Transposase and inactivated derivatives
A3858_16935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3858_16940	COG3284	Transcriptional regulator
A3858_16950	COG2909	trisaccharide binding
A3858_16955	COG2244	polysaccharide biosynthetic process
A3858_16960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3858_16985	COG0471	metal ion transport
A3858_16985	COG3273	potassium ion transport
A3858_16995	COG1346	cytolysis
A3858_17015	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_17025	COG3842	ATPase activity
A3858_17040	COG2962	Rard protein
A3858_17055	COG3706	GGDEF domain
A3858_17145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3858_17165	COG3706	GGDEF domain
A3858_17170	COG0154	amidase activity
A3858_17185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3858_17190	COG0577	efflux transmembrane transporter activity
A3858_17190	COG1136	(ABC) transporter
A3858_17195	COG0577	efflux transmembrane transporter activity
A3858_17195	COG1136	(ABC) transporter
A3858_17205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A3858_17245	COG4948	Mandelate Racemase Muconate Lactonizing
A3858_17250	COG0583	DNA-binding transcription factor activity
A3858_17270	COG0473	3-isopropylmalate dehydrogenase activity
A3858_17275	COG1120	ATPase activity
A3858_17280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3858_17290	COG1177	transmembrane transport
A3858_17295	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_17300	COG3842	ATPase activity
A3858_17305	COG1840	ABC-type Fe3 transport system, periplasmic component
A3858_17310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3858_17315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3858_17320	COG0583	DNA-binding transcription factor activity
A3858_17325	COG3706	GGDEF domain
A3858_17340	COG3395	kinase activity
A3858_17350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A3858_17360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3858_17380	COG1454	alcohol dehydrogenase
A3858_17385	COG1120	ATPase activity
A3858_17390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3858_17395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3858_17405	COG4774	siderophore transport
A3858_17420	COG0840	transmembrane signaling receptor activity
A3858_17435	COG0708	Exodeoxyribonuclease III
A3858_17450	COG0754	glutathionylspermidine amidase activity
A3858_17470	COG0745	RESPONSE REGULATOR receiver
A3858_17475	COG0642	Histidine kinase
A3858_17480	COG0840	transmembrane signaling receptor activity
A3858_17500	COG0583	DNA-binding transcription factor activity
A3858_17520	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_17525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3858_17530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3858_17540	COG0006	proline dipeptidase activity
A3858_17545	COG1802	Transcriptional regulator
A3858_17560	COG1802	Transcriptional regulator
A3858_17565	COG1984	allophanate hydrolase subunit 2
A3858_17570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3858_17585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3858_17590	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3858_17595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3858_17615	COG0765	amino acid transport
A3858_17620	COG0765	amino acid transport
A3858_17645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3858_17760	COG3501	Rhs element vgr protein
A3858_17775	COG0631	protein serine/threonine phosphatase activity
A3858_17820	COG3347	Dehydrogenase
A3858_17820	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_17825	COG1879	ABC-type sugar transport system periplasmic component
A3858_17835	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_17845	COG2390	Transcriptional regulator
A3858_17875	COG0745	RESPONSE REGULATOR receiver
A3858_17880	COG2205	protein histidine kinase activity
A3858_17885	COG3706	GGDEF domain
A3858_17900	COG3842	ATPase activity
A3858_17905	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3858_17910	COG1177	transmembrane transport
A3858_17915	COG3938	Belongs to the proline racemase family
A3858_17925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3858_17930	COG0601	transmembrane transport
A3858_17935	COG0747	negative chemotaxis
A3858_17940	COG0747	negative chemotaxis
A3858_17970	COG0318	PFAM AMP-dependent synthetase and ligase
A3858_17975	COG1012	belongs to the aldehyde dehydrogenase family
A3858_17980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3858_17995	COG2130	NADP-dependent
A3858_18045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A3858_18050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A3858_18055	COG0124	histidyl-tRNA synthetase
A3858_18065	COG0587	DNA-directed DNA polymerase activity
A3858_18105	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3858_18125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3858_18130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3858_18135	COG1121	(ABC) transporter
A3858_18145	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A3858_18160	COG2986	histidine ammonia-lyase
A3858_18230	COG0133	tryptophan synthase activity
A3858_18240	COG0135	phosphoribosylanthranilate isomerase activity
A3858_18250	COG0776	regulation of translation
A3858_18255	COG0539	negative regulation of cytoplasmic translation
A3858_18260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3858_18265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A3858_18270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3858_18285	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A3858_18290	COG4535	Mg2 and Co2 transporter CorC
A3858_18295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A3858_18300	COG1702	phosphate starvation-inducible protein PhoH
A3858_18305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3858_18315	COG4181	ATPase activity
A3858_18320	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A3858_18330	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A3858_18370	COG3750	Belongs to the UPF0335 family
A3858_18425	COG3459	Glycosyltransferase 36 associated
A3858_18435	COG0459	protein refolding
A3858_18470	COG1278	Cold shock
A3858_18475	COG1278	Cold shock
A3858_18575	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A3858_18635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3858_18645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3858_18660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3858_18665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3858_18670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A3858_18675	COG2186	Transcriptional regulator
A3858_18685	COG2197	response regulator
A3858_18715	COG1175	transmembrane transport
A3858_18730	COG1802	Transcriptional regulator
A3858_18735	COG3842	ATPase activity
A3858_18755	COG1902	pentaerythritol trinitrate reductase activity
A3858_18755	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3858_18785	COG1879	ABC-type sugar transport system periplasmic component
A3858_18795	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_18810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3858_18825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3858_18830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3858_18845	COG4208	sulfate ABC transporter
A3858_18865	COG4214	carbohydrate transport
A3858_18885	COG1252	NADH dehydrogenase
A3858_18890	COG0840	transmembrane signaling receptor activity
A3858_18900	COG2212	antiporter activity
A3858_18905	COG1863	multisubunit Na H antiporter MnhE subunit
A3858_18910	COG0651	ATP synthesis coupled electron transport
A3858_18915	COG1006	Multisubunit Na H antiporter MnhC subunit
A3858_18920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3858_18920	COG2111	Na H antiporter
A3858_18975	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A3858_18980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A3858_18990	COG0625	glutathione transferase activity
A3858_18995	COG1349	DNA-binding transcription factor activity
A3858_19000	COG1879	ABC-type sugar transport system periplasmic component
A3858_19005	COG1129	ABC transporter
A3858_19010	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3858_19030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3858_19035	COG1012	belongs to the aldehyde dehydrogenase family
A3858_19040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3858_19050	COG0765	amino acid transport
A3858_19100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3858_19170	COG0393	Putative heavy-metal-binding
A3858_19345	COG4974	Belongs to the 'phage' integrase family
A3858_19360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3858_19365	COG0589	response to stress
A3858_19425	COG1192	Involved in chromosome partitioning
A3858_19515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3858_19710	COG0336	Belongs to the RNA methyltransferase TrmD family
A3858_19725	COG2801	Transposase and inactivated derivatives
A3858_19740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3858_19820	COG4372	Transposase
A3858_19855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3858_19880	COG4372	Transposase
A3858_19890	COG2963	transposase activity
A3858_19910	COG2161	toxin-antitoxin pair type II binding
A3858_19945	COG4372	Transposase
A3858_19960	COG1192	Involved in chromosome partitioning
A3858_19975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3858_20005	COG0659	secondary active sulfate transmembrane transporter activity
A3858_20010	COG0589	response to stress
A3858_20015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A3858_20025	COG0640	Transcriptional regulator
A3858_20030	COG0701	Predicted permease
A3858_20045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3858_20065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A3858_20190	COG0356	it plays a direct role in the translocation of protons across the membrane
A3858_20210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3858_20215	COG2801	Transposase and inactivated derivatives
A3858_20250	COG4372	Transposase
A3858_20265	COG2207	Transcriptional regulator
A3858_20290	COG4774	siderophore transport
A3858_20305	COG1120	ATPase activity
A3858_20325	COG1280	lysine exporter protein (LysE YggA)
A3858_20335	COG2267	carboxylic ester hydrolase activity
A3858_20355	COG0589	response to stress
A3858_20360	COG0659	secondary active sulfate transmembrane transporter activity
A3858_20370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3858_20375	COG1802	Transcriptional regulator
A3858_20380	COG0747	negative chemotaxis
A3858_20395	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_20400	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_20405	COG4948	Mandelate Racemase Muconate Lactonizing
A3858_20410	COG3608	succinylglutamate desuccinylase aspartoacylase
A3858_20420	COG4948	Mandelate Racemase Muconate Lactonizing
A3858_20430	COG4608	Belongs to the ABC transporter superfamily
A3858_20440	COG5443	negative regulation of bacterial-type flagellum assembly
A3858_20450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A3858_20465	COG2186	Transcriptional regulator
A3858_20485	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3858_20490	COG4149	molybdate abc transporter
A3858_20495	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A3858_20505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3858_20515	COG1959	2 iron, 2 sulfur cluster binding
A3858_20530	COG0583	DNA-binding transcription factor activity
A3858_20535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A3858_20545	COG4208	sulfate ABC transporter
A3858_20550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3858_20555	COG1522	sequence-specific DNA binding
A3858_20595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A3858_20615	COG1091	dTDP-4-dehydrorhamnose reductase activity
A3858_20620	COG1088	dTDP-glucose 4,6-dehydratase activity
A3858_20625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A3858_20640	COG1192	Involved in chromosome partitioning
A3858_20720	COG2200	EAL domain
A3858_20725	COG3550	peptidyl-serine autophosphorylation
A3858_20765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3858_20775	COG2801	Transposase and inactivated derivatives
A3858_20830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3858_20895	COG3062	negative regulation of establishment of protein localization
A3858_20905	COG4459	periplasmic nitrate reductase
A3858_20925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3858_20935	COG1192	Involved in chromosome partitioning
A3858_20965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3858_20970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3858_21005	COG0110	maltose O-acetyltransferase activity
A3858_21030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3858_21045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3858_21170	COG0583	DNA-binding transcription factor activity
A3858_21175	COG4638	Rieske (2fe-2S)
A3858_21195	COG3920	Histidine kinase
A3858_21200	COG4251	negative regulation of phosphorylation
A3858_21205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3858_21250	COG2323	membrane
A3858_21275	COG2113	Glycine betaine
A3858_21280	COG4176	ABC-type proline glycine betaine transport system permease component
A3858_21285	COG3448	diguanylate cyclase activity
A3858_21285	COG4175	Glycine betaine
A3858_21295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3858_21300	COG1012	belongs to the aldehyde dehydrogenase family
A3858_21310	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_21315	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_21320	COG4948	Mandelate Racemase Muconate Lactonizing
A3858_21325	COG5598	trimethylamine methyltransferase
A3858_21335	COG2855	membrane
A3858_21340	COG0028	Belongs to the TPP enzyme family
A3858_21345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_21365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3858_21370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3858_21375	COG3706	GGDEF domain
A3858_21385	COG0583	DNA-binding transcription factor activity
A3858_21390	COG0114	fumarate hydratase activity
A3858_21395	COG1414	Transcriptional regulator
A3858_21400	COG1475	DNA binding
A3858_21405	COG1192	Involved in chromosome partitioning
A3858_21415	COG2223	nitrite transmembrane transporter activity
A3858_21420	COG3180	Ammonia monooxygenase
A3858_21430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3858_21435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3858_21445	COG0473	3-isopropylmalate dehydrogenase activity
A3858_21455	COG1063	alcohol dehydrogenase
A3858_21460	COG3842	ATPase activity
A3858_21465	COG0395	ABC-type sugar transport system, permease component
A3858_21490	COG2801	Transposase and inactivated derivatives
A3858_21495	COG1609	Transcriptional regulator
A3858_21510	COG1175	transmembrane transport
A3858_21515	COG0395	ABC-type sugar transport system, permease component
A3858_21525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3858_21530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3858_21535	COG3842	ATPase activity
A3858_21540	COG2188	Transcriptional regulator
A3858_21545	COG0252	asparaginase activity
A3858_21550	COG1126	abc transporter atp-binding protein
A3858_21560	COG0765	amino acid transport
A3858_21565	COG0765	amino acid transport
A3858_21575	COG0165	Argininosuccinate lyase
A3858_21585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3858_21590	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_21600	COG0583	DNA-binding transcription factor activity
A3858_21610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3858_21620	COG0410	ABC transporter
A3858_21630	COG4177	L-phenylalanine transmembrane transporter activity
A3858_21635	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3858_21645	COG3246	L-lysine catabolic process to acetate
A3858_21660	COG1028	Short-chain dehydrogenase reductase Sdr
A3858_21715	COG0405	Gamma-glutamyltransferase
A3858_21720	COG1850	ribulose-bisphosphate carboxylase activity