locus-tag	class	description
F1734_00020	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_00025	COG2072	flavoprotein involved in K transport
F1734_00040	COG2072	flavoprotein involved in K transport
F1734_00045	COG1902	pentaerythritol trinitrate reductase activity
F1734_00045	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1734_00055	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_00080	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1734_00085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1734_00085	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1734_00095	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_00120	COG1053	succinate dehydrogenase
F1734_00130	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_00145	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_00165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_00170	COG1012	belongs to the aldehyde dehydrogenase family
F1734_00175	COG2030	dehydratase
F1734_00195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_00215	COG0183	Belongs to the thiolase family
F1734_00225	COG1024	Enoyl-CoA hydratase
F1734_00265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F1734_00280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F1734_00325	COG2814	Major facilitator Superfamily
F1734_00330	COG1309	transcriptional regulator
F1734_00335	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_00350	COG1960	acyl-CoA dehydrogenase activity
F1734_00355	COG1960	acyl-CoA dehydrogenase activity
F1734_00360	COG1960	acyl-CoA dehydrogenase activity
F1734_00365	COG0183	Belongs to the thiolase family
F1734_00395	COG1309	transcriptional regulator
F1734_00400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_00405	COG0183	Belongs to the thiolase family
F1734_00410	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_00425	COG1960	acyl-CoA dehydrogenase activity
F1734_00445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1734_00455	COG2318	DinB family
F1734_00465	COG0789	Transcriptional regulator
F1734_00470	COG0667	Aldo Keto reductase
F1734_00475	COG1609	Transcriptional regulator
F1734_00480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F1734_00485	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F1734_00485	COG1082	Xylose isomerase domain protein TIM barrel
F1734_00530	COG1358	cellular component organization or biogenesis
F1734_00550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_00555	COG0583	DNA-binding transcription factor activity
F1734_00560	COG0583	DNA-binding transcription factor activity
F1734_00565	COG0183	Belongs to the thiolase family
F1734_00575	COG1960	acyl-CoA dehydrogenase activity
F1734_00590	COG0183	Belongs to the thiolase family
F1734_00595	COG2271	Major facilitator Superfamily
F1734_00600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_00605	COG1960	acyl-CoA dehydrogenase activity
F1734_00620	COG1053	succinate dehydrogenase
F1734_00625	COG0673	inositol 2-dehydrogenase activity
F1734_00630	COG0656	L-ascorbic acid biosynthetic process
F1734_00640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1734_00650	COG0583	DNA-binding transcription factor activity
F1734_00655	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_00665	COG1414	Transcriptional regulator
F1734_00690	COG2193	ferroxidase activity
F1734_00695	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F1734_00700	COG1846	Transcriptional regulator
F1734_00710	COG2890	protein-(glutamine-N5) methyltransferase activity
F1734_00760	COG1940	carbohydrate kinase activity
F1734_00760	COG1846	Transcriptional regulator
F1734_00765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F1734_00775	COG0800	Aldolase
F1734_00780	COG1940	carbohydrate kinase activity
F1734_00785	COG0477	Major facilitator Superfamily
F1734_00790	COG1940	carbohydrate kinase activity
F1734_00810	COG1982	Orn Lys Arg decarboxylase major
F1734_00860	COG3387	PFAM Glycoside hydrolase 15-related
F1734_00880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F1734_00895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_00945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1734_00950	COG0477	Major facilitator Superfamily
F1734_00955	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_00960	COG1131	(ABC) transporter
F1734_00960	COG1716	ATPase activity
F1734_00960	COG0842	Transport permease protein
F1734_00970	COG4977	sequence-specific DNA binding
F1734_00980	COG0069	glutamate synthase activity
F1734_00985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F1734_00995	COG4208	sulfate ABC transporter
F1734_01000	COG3842	ATPase activity
F1734_01010	COG1126	abc transporter atp-binding protein
F1734_01015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1734_01020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1734_01030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_01035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_01040	COG0477	Major facilitator Superfamily
F1734_01045	COG0747	negative chemotaxis
F1734_01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1734_01060	COG4172	Belongs to the ABC transporter superfamily
F1734_01065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_01090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_01120	COG0431	NADPH-dependent FMN reductase
F1734_01125	COG0745	RESPONSE REGULATOR receiver
F1734_01150	COG1464	Belongs to the NlpA lipoprotein family
F1734_01155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F1734_01160	COG2011	ABC-type metal ion transport system permease component
F1734_01165	COG2855	membrane
F1734_01170	COG0405	Gamma-glutamyltransferase
F1734_01200	COG1372	Participates in initiation and elongation during chromosome replication
F1734_01200	COG0305	Participates in initiation and elongation during chromosome replication
F1734_01205	COG0359	binds to the 23S rRNA
F1734_01210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1734_01215	COG0629	single-stranded DNA binding
F1734_01245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1734_01270	COG1695	Transcriptional regulator
F1734_01300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1734_01325	COG3842	ATPase activity
F1734_01395	COG1960	acyl-CoA dehydrogenase activity
F1734_01400	COG1960	acyl-CoA dehydrogenase activity
F1734_01435	COG0765	amino acid transport
F1734_01440	COG1126	abc transporter atp-binding protein
F1734_01455	COG3835	regulator
F1734_01470	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_01475	COG1113	amino acid transport
F1734_01525	COG1012	belongs to the aldehyde dehydrogenase family
F1734_01530	COG1960	acyl-CoA dehydrogenase activity
F1734_01535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F1734_01540	COG2902	Dehydrogenase
F1734_01550	COG0459	protein refolding
F1734_01555	COG1064	alcohol dehydrogenase
F1734_01580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1734_01585	COG3350	monooxygenase activity
F1734_01595	COG0753	catalase activity
F1734_01600	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
F1734_01610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1734_01625	COG1796	DNA polymerase
F1734_01625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1734_01635	COG0300	oxidoreductase activity
F1734_01645	COG1253	flavin adenine dinucleotide binding
F1734_01650	COG3631	Ketosteroid isomerase-related protein
F1734_01655	COG1253	flavin adenine dinucleotide binding
F1734_01665	COG2267	carboxylic ester hydrolase activity
F1734_01675	COG0495	leucyl-tRNA aminoacylation
F1734_01700	COG0076	glutamate decarboxylase activity
F1734_01710	COG4303	Ethanolamine ammonia lyase large subunit
F1734_01715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F1734_01730	COG0154	amidase activity
F1734_01735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1734_01760	COG1678	Uncharacterized ACR, COG1678
F1734_01805	COG3585	molybdate ion transport
F1734_01810	COG0243	molybdopterin cofactor binding
F1734_01815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
F1734_01825	COG0617	tRNA 3'-terminal CCA addition
F1734_01845	COG1595	DNA-templated transcription, initiation
F1734_01855	COG1309	transcriptional regulator
F1734_01875	COG0492	ferredoxin-NADP+ reductase activity
F1734_01875	COG3118	belongs to the thioredoxin family
F1734_01880	COG3409	Peptidoglycan-binding domain 1 protein
F1734_01880	COG0860	N-Acetylmuramoyl-L-alanine amidase
F1734_01895	COG1192	Involved in chromosome partitioning
F1734_01900	COG0357	Ribosomal RNA small subunit methyltransferase G
F1734_01910	COG0706	membrane insertase activity
F1734_01915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1734_01925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F1734_01930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1734_01935	COG0592	DNA-directed DNA polymerase activity
F1734_01945	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
F1734_01965	COG0187	DNA topoisomerase II activity
F1734_01975	COG2018	Roadblock/LC7 domain
F1734_02000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1734_02000	COG1372	Participates in initiation and elongation during chromosome replication
F1734_02020	COG4974	Belongs to the 'phage' integrase family
F1734_02120	COG4974	Belongs to the 'phage' integrase family
F1734_02140	COG0693	protein deglycase activity
F1734_02155	COG2837	iron assimilation
F1734_02160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1734_02190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1734_02195	COG0705	Rhomboid family
F1734_02195	COG0457	Tetratricopeptide repeat
F1734_02220	COG0515	serine threonine protein kinase
F1734_02220	COG2815	serine threonine protein kinase
F1734_02225	COG0515	serine threonine protein kinase
F1734_02230	COG0768	penicillin binding
F1734_02245	COG1716	ATPase activity
F1734_02250	COG1716	ATPase activity
F1734_02280	COG0069	glutamate synthase activity
F1734_02280	COG0070	glutamate synthase
F1734_02280	COG0067	glutamate synthase
F1734_02295	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
F1734_02310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F1734_02335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1734_02335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1734_02350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F1734_02355	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F1734_02360	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F1734_02380	COG2409	Drug exporters of the RND superfamily
F1734_02390	COG5343	regulation of RNA biosynthetic process
F1734_02420	COG0702	epimerase
F1734_02430	COG0415	Belongs to the DNA photolyase family
F1734_02435	COG2501	S4 domain
F1734_02455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F1734_02540	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_02590	COG1012	belongs to the aldehyde dehydrogenase family
F1734_02595	COG3706	GGDEF domain
F1734_02610	COG2072	flavoprotein involved in K transport
F1734_02635	COG1573	uracil-dna glycosylase
F1734_02705	COG2814	Major facilitator Superfamily
F1734_02715	COG2119	membrane
F1734_02725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F1734_02735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1734_02770	COG1316	TRANSCRIPTIONal
F1734_02815	COG1024	Enoyl-CoA hydratase
F1734_02820	COG3321	synthase
F1734_02820	COG0604	alcohol dehydrogenase
F1734_02820	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_02825	COG1024	Enoyl-CoA hydratase
F1734_02830	COG0183	Belongs to the thiolase family
F1734_02850	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_02885	COG1024	Enoyl-CoA hydratase
F1734_02970	COG1597	lipid kinase activity
F1734_02975	COG0477	Major facilitator Superfamily
F1734_02980	COG0121	glutamine amidotransferase
F1734_03005	COG1937	Protein conserved in bacteria
F1734_03010	COG3453	Protein conserved in bacteria
F1734_03010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_03020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1734_03035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1734_03060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1734_03090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1734_03115	COG2146	nitrite reductase [NAD(P)H] activity
F1734_03115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1734_03120	COG0204	Acyl-transferase
F1734_03125	COG0561	phosphatase activity
F1734_03135	COG2385	sporulation resulting in formation of a cellular spore
F1734_03140	COG0438	transferase activity, transferring glycosyl groups
F1734_03160	COG2814	Major facilitator Superfamily
F1734_03170	COG0789	Transcriptional regulator
F1734_03180	COG1216	Glycosyl transferase, family 2
F1734_03190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F1734_03195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F1734_03205	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1734_03205	COG5479	isomerase activity
F1734_03215	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
F1734_03225	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_03230	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F1734_03230	COG3321	synthase
F1734_03230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1734_03235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1734_03270	COG0277	FAD linked oxidase domain protein
F1734_03285	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_03290	COG0277	FAD linked oxidase domain protein
F1734_03305	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F1734_03310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F1734_03315	COG1088	dTDP-glucose 4,6-dehydratase activity
F1734_03345	COG1216	Glycosyl transferase, family 2
F1734_03370	COG1063	alcohol dehydrogenase
F1734_03390	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1734_03390	COG5479	isomerase activity
F1734_03395	COG0737	Belongs to the 5'-nucleotidase family
F1734_03400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1734_03420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1734_03420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_03425	COG0730	response to heat
F1734_03435	COG0270	DNA (cytosine-5-)-methyltransferase activity
F1734_03475	COG0154	amidase activity
F1734_03480	COG0287	Prephenate dehydrogenase
F1734_03490	COG0590	tRNA wobble adenosine to inosine editing
F1734_03525	COG2409	Drug exporters of the RND superfamily
F1734_03555	COG2072	flavoprotein involved in K transport
F1734_03580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1734_03595	COG2814	Major facilitator Superfamily
F1734_03600	COG0343	queuine tRNA-ribosyltransferase activity
F1734_03610	COG5473	translation initiation factor activity
F1734_03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1734_03635	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_03640	COG3226	Transcriptional regulator
F1734_03695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1734_03700	COG0596	Alpha beta hydrolase
F1734_03750	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_03780	COG1012	belongs to the aldehyde dehydrogenase family
F1734_03820	COG3655	Transcriptional regulator
F1734_03835	COG2197	response regulator
F1734_03840	COG0183	Belongs to the thiolase family
F1734_03845	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1734_03845	COG1024	Enoyl-CoA hydratase
F1734_03855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1734_03870	COG0860	N-Acetylmuramoyl-L-alanine amidase
F1734_03875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1734_03880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1734_03885	COG1309	transcriptional regulator
F1734_03905	COG1960	acyl-CoA dehydrogenase activity
F1734_03930	COG3385	transposase activity
F1734_03940	COG1024	Enoyl-CoA hydratase
F1734_03955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1734_03965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F1734_04010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1734_04025	COG1024	Enoyl-CoA hydratase
F1734_04035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1734_04065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F1734_04070	COG1522	sequence-specific DNA binding
F1734_04075	COG0778	Nitroreductase
F1734_04080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_04085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1734_04090	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1734_04110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1734_04110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1734_04150	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_04160	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_04235	COG0384	phenazine biosynthesis protein PhzF
F1734_04240	COG0477	Major facilitator Superfamily
F1734_04250	COG1960	acyl-CoA dehydrogenase activity
F1734_04290	COG0783	Belongs to the Dps family
F1734_04340	COG1408	metallophosphoesterase
F1734_04380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_04415	COG2267	carboxylic ester hydrolase activity
F1734_04425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F1734_04430	COG0477	Major facilitator Superfamily
F1734_04435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_04485	COG1111	helicase
F1734_04485	COG1205	dead DEAH box helicase
F1734_04490	COG1278	Cold shock
F1734_04500	COG1754	DNA topoisomerase type I activity
F1734_04500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1734_04515	COG0470	DNA polymerase III
F1734_04570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1734_04575	COG0442	prolyl-tRNA aminoacylation
F1734_04600	COG2027	D-alanyl-D-alanine carboxypeptidase
F1734_04610	COG0037	tRNA processing
F1734_04625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1734_04630	COG0302	gtp cyclohydrolase
F1734_04635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1734_04640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F1734_04665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F1734_04670	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1734_04675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F1734_04685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1734_04695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F1734_04720	COG1960	acyl-CoA dehydrogenase activity
F1734_04740	COG4762	Protein conserved in bacteria
F1734_04760	COG0288	reversible hydration of carbon dioxide
F1734_04770	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F1734_04780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F1734_04785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F1734_04795	COG1329	Transcriptional regulator
F1734_04805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F1734_04810	COG0215	cysteine-tRNA ligase activity
F1734_04815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1734_04825	COG1984	allophanate hydrolase subunit 2
F1734_04835	COG3293	Transposase
F1734_04845	COG2409	Drug exporters of the RND superfamily
F1734_04880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1734_04890	COG2267	carboxylic ester hydrolase activity
F1734_04895	COG2267	carboxylic ester hydrolase activity
F1734_04905	COG0475	glutathione-regulated potassium exporter activity
F1734_04925	COG0477	Major facilitator Superfamily
F1734_04940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1734_04945	COG1120	ATPase activity
F1734_04950	COG0803	Belongs to the bacterial solute-binding protein 9 family
F1734_04955	COG1609	Transcriptional regulator
F1734_04960	COG3387	PFAM Glycoside hydrolase 15-related
F1734_04965	COG1309	transcriptional regulator
F1734_04970	COG1960	acyl-CoA dehydrogenase activity
F1734_04975	COG1960	acyl-CoA dehydrogenase activity
F1734_04980	COG1960	acyl-CoA dehydrogenase activity
F1734_04985	COG2030	dehydratase
F1734_05005	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_05045	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
F1734_05045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1734_05100	COG1793	dna ligase
F1734_05100	COG3285	dna ligase
F1734_05110	COG0583	DNA-binding transcription factor activity
F1734_05120	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F1734_05135	COG2030	dehydratase
F1734_05140	COG1053	succinate dehydrogenase
F1734_05145	COG3971	2-oxopent-4-enoate hydratase activity
F1734_05150	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F1734_05155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1734_05160	COG2197	response regulator
F1734_05165	COG4585	Histidine kinase
F1734_05175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F1734_05200	COG1960	acyl-CoA dehydrogenase activity
F1734_05205	COG2267	carboxylic ester hydrolase activity
F1734_05210	COG0346	lactoylglutathione lyase activity
F1734_05215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1734_05235	COG0656	L-ascorbic acid biosynthetic process
F1734_05245	COG1960	acyl-CoA dehydrogenase activity
F1734_05250	COG1960	acyl-CoA dehydrogenase activity
F1734_05255	COG1960	acyl-CoA dehydrogenase activity
F1734_05260	COG1024	Enoyl-CoA hydratase
F1734_05265	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_05270	COG1960	acyl-CoA dehydrogenase activity
F1734_05280	COG1309	transcriptional regulator
F1734_05285	COG0183	Belongs to the thiolase family
F1734_05300	COG1309	transcriptional regulator
F1734_05335	COG1024	Enoyl-CoA hydratase
F1734_05340	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_05345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1734_05355	COG0183	Belongs to the thiolase family
F1734_05360	COG2124	cytochrome p450
F1734_05365	COG1053	succinate dehydrogenase
F1734_05390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1734_05395	COG0183	Belongs to the thiolase family
F1734_05405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_05420	COG2070	2-Nitropropane dioxygenase
F1734_05445	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_05450	COG1960	acyl-CoA dehydrogenase activity
F1734_05455	COG1960	acyl-CoA dehydrogenase activity
F1734_05465	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_05475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1734_05500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F1734_05520	COG0784	Response regulator, receiver
F1734_05525	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F1734_05535	COG1132	(ABC) transporter
F1734_05550	COG0697	spore germination
F1734_05560	COG0183	Belongs to the thiolase family
F1734_05585	COG0596	Alpha beta hydrolase
F1734_05590	COG2770	Histidine kinase
F1734_05590	COG2208	phosphoserine phosphatase activity
F1734_05595	COG1024	Enoyl-CoA hydratase
F1734_05605	COG1960	acyl-CoA dehydrogenase activity
F1734_05610	COG1960	acyl-CoA dehydrogenase activity
F1734_05615	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_05620	COG1946	Acyl-CoA thioesterase
F1734_05625	COG1011	Hydrolase
F1734_05645	COG2130	NADP-dependent
F1734_05695	COG2815	serine threonine protein kinase
F1734_05695	COG0515	serine threonine protein kinase
F1734_05725	COG0745	RESPONSE REGULATOR receiver
F1734_05730	COG2205	protein histidine kinase activity
F1734_05755	COG0436	Aminotransferase
F1734_05765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F1734_05790	COG0477	Major facilitator Superfamily
F1734_05795	COG1846	Transcriptional regulator
F1734_05820	COG1132	(ABC) transporter
F1734_05825	COG3433	isochorismatase activity
F1734_05825	COG1535	isochorismatase
F1734_05830	COG1021	2,3-dihydroxybenzoate-AMP ligase
F1734_05835	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_05845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_05875	COG2226	methyltransferase
F1734_05885	COG0640	Transcriptional regulator
F1734_05900	COG2357	RelA SpoT domain protein
F1734_05905	COG2375	cellular response to nickel ion
F1734_05910	COG0477	Major facilitator Superfamily
F1734_05915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F1734_05925	COG4565	transcriptional regulatory protein
F1734_05930	COG3290	protein histidine kinase activity
F1734_05935	COG1301	dicarboxylic acid transport
F1734_05945	COG0583	DNA-binding transcription factor activity
F1734_05950	COG3634	alkyl hydroperoxide reductase activity
F1734_05960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_05980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F1734_05990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_06010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1734_06015	COG1120	ATPase activity
F1734_06060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F1734_06075	COG2132	Multicopper oxidase
F1734_06095	COG0386	Belongs to the glutathione peroxidase family
F1734_06100	COG0778	Nitroreductase
F1734_06110	COG3573	Dehydrogenase
F1734_06125	COG2272	Belongs to the type-B carboxylesterase lipase family
F1734_06150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1734_06155	COG0047	phosphoribosylformylglycinamidine synthase activity
F1734_06160	COG5002	protein histidine kinase activity
F1734_06165	COG0745	RESPONSE REGULATOR receiver
F1734_06180	COG2217	Heavy metal translocating P-type atpase
F1734_06200	COG1362	aminopeptidase activity
F1734_06235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1734_06265	COG1271	oxidase subunit
F1734_06270	COG1294	oxidase, subunit
F1734_06275	COG4988	ABC transporter
F1734_06280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F1734_06285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F1734_06290	COG4044	May play a role in the intracellular transport of hydrophobic ligands
F1734_06305	COG2897	thiosulfate sulfurtransferase activity
F1734_06325	COG0745	RESPONSE REGULATOR receiver
F1734_06345	COG0581	inorganic phosphate transmembrane transporter activity
F1734_06350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1734_06420	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_06430	COG0438	transferase activity, transferring glycosyl groups
F1734_06435	COG2226	methyltransferase
F1734_06480	COG2124	cytochrome p450
F1734_06520	COG1053	succinate dehydrogenase
F1734_06520	COG3976	FMN-binding domain protein
F1734_06530	COG1309	transcriptional regulator
F1734_06545	COG0733	neurotransmitter:sodium symporter activity
F1734_06580	COG0589	response to stress
F1734_06610	COG0564	pseudouridine synthase activity
F1734_06650	COG0569	domain protein
F1734_06655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F1734_06675	COG1764	response to oxidative stress
F1734_06680	COG1846	Transcriptional regulator
F1734_06685	COG0542	response to heat
F1734_06695	COG0366	Alpha amylase catalytic
F1734_06700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F1734_06705	COG1216	Glycosyl transferase, family 2
F1734_06710	COG5285	phytanoyl-CoA dioxygenase
F1734_06745	COG1595	DNA-templated transcription, initiation
F1734_06760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F1734_06765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_06775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1734_06795	COG2851	Citrate transporter
F1734_06800	COG3290	protein histidine kinase activity
F1734_06805	COG4565	transcriptional regulatory protein
F1734_06825	COG1652	LysM domain
F1734_06840	COG1278	Cold shock
F1734_06850	COG2814	Major facilitator Superfamily
F1734_06870	COG0671	phosphoesterase, PA-phosphatase related
F1734_06880	COG2252	PERMEase
F1734_06920	COG0259	pyridoxamine-phosphate oxidase activity
F1734_06925	COG0477	Major facilitator Superfamily
F1734_06930	COG4106	trans-aconitate 2-methyltransferase activity
F1734_06940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1734_06945	COG2017	converts alpha-aldose to the beta-anomer
F1734_06955	COG0545	Peptidyl-prolyl cis-trans isomerase
F1734_06965	COG2205	protein histidine kinase activity
F1734_06975	COG1309	transcriptional regulator
F1734_06980	COG1960	acyl-CoA dehydrogenase activity
F1734_06985	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F1734_06995	COG1546	Belongs to the CinA family
F1734_06995	COG1058	Belongs to the CinA family
F1734_07000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1734_07010	COG1295	ribonuclease BN
F1734_07035	COG1668	transmembrane transport
F1734_07040	COG4152	abc transporter atp-binding protein
F1734_07060	COG0488	(ABC) transporter
F1734_07065	COG0656	L-ascorbic acid biosynthetic process
F1734_07075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1734_07115	COG0583	DNA-binding transcription factor activity
F1734_07125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1734_07160	COG3275	phosphorelay sensor kinase activity
F1734_07165	COG3279	Response regulator of the LytR AlgR family
F1734_07180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1734_07190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1734_07215	COG2020	methyltransferase activity
F1734_07220	COG1742	UPF0060 membrane protein
F1734_07245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1734_07250	COG1937	Protein conserved in bacteria
F1734_07295	COG0739	heme binding
F1734_07305	COG2234	aminopeptidase activity
F1734_07310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1734_07310	COG1017	nitric oxide dioxygenase activity
F1734_07315	COG1959	2 iron, 2 sulfur cluster binding
F1734_07320	COG2239	Acts as a magnesium transporter
F1734_07330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_07390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1734_07395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F1734_07410	COG2272	Belongs to the type-B carboxylesterase lipase family
F1734_07420	COG1309	transcriptional regulator
F1734_07425	COG1960	acyl-CoA dehydrogenase activity
F1734_07435	COG0166	Belongs to the GPI family
F1734_07455	COG0739	heme binding
F1734_07465	COG0045	succinate-CoA ligase (ADP-forming) activity
F1734_07475	COG1739	Uncharacterized protein family UPF0029
F1734_07505	COG1073	alpha beta
F1734_07515	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
F1734_07535	COG0679	Auxin Efflux Carrier
F1734_07540	COG2188	Transcriptional regulator
F1734_07555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
F1734_07560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F1734_07565	COG3639	organic phosphonate transmembrane transporter activity
F1734_07580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1734_07585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1734_07590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1734_07595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1734_07625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1734_07630	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1734_07630	COG0315	cyclic pyranopterin monophosphate synthase activity
F1734_07645	COG1970	mechanosensitive ion channel activity
F1734_07660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F1734_07665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1734_07675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1734_07685	COG2226	methyltransferase
F1734_07705	COG1136	(ABC) transporter
F1734_07720	COG2197	response regulator
F1734_07725	COG4044	May play a role in the intracellular transport of hydrophobic ligands
F1734_07740	COG1725	Transcriptional regulator
F1734_07760	COG1115	amino acid carrier protein
F1734_07765	COG2319	Wd-40 repeat
F1734_07775	COG1595	DNA-templated transcription, initiation
F1734_07795	COG0084	hydrolase, TatD family'
F1734_07810	COG0346	lactoylglutathione lyase activity
F1734_07815	COG2259	Doxx family
F1734_07820	COG3583	domain protein
F1734_07825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1734_07830	COG1278	Cold shock
F1734_07835	COG1278	Cold shock
F1734_07845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1734_07850	COG0488	(ABC) transporter
F1734_07855	COG1024	Enoyl-CoA hydratase
F1734_07890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F1734_07895	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_07900	COG0193	aminoacyl-tRNA hydrolase activity
F1734_07910	COG1053	succinate dehydrogenase
F1734_07910	COG3976	FMN-binding domain protein
F1734_07915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F1734_07925	COG3572	ergothioneine biosynthetic process
F1734_07935	COG0121	glutamine amidotransferase
F1734_07940	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F1734_07945	COG2814	Major facilitator Superfamily
F1734_07950	COG0477	Major facilitator Superfamily
F1734_07955	COG2226	methyltransferase
F1734_07960	COG2197	response regulator
F1734_07990	COG1309	transcriptional regulator
F1734_08015	COG3956	TIGRFAM MazG family protein
F1734_08045	COG0438	transferase activity, transferring glycosyl groups
F1734_08055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F1734_08075	COG1215	transferase activity, transferring glycosyl groups
F1734_08095	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F1734_08110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F1734_08150	COG2837	iron assimilation
F1734_08255	COG0670	Belongs to the BI1 family
F1734_08260	COG2755	lipolytic protein G-D-S-L family
F1734_08275	COG0791	NLP P60 protein
F1734_08280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1734_08290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1734_08300	COG1331	Highly conserved protein containing a thioredoxin domain
F1734_08305	COG0668	transmembrane transport
F1734_08315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1734_08330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1734_08335	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F1734_08345	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
F1734_08380	COG0477	Major facilitator Superfamily
F1734_08385	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_08410	COG1722	exodeoxyribonuclease VII activity
F1734_08415	COG1570	exodeoxyribonuclease VII activity
F1734_08435	COG1322	Protein conserved in bacteria
F1734_08445	COG0419	ATPase involved in DNA repair
F1734_08465	COG0012	GTP binding
F1734_08500	COG0277	FAD linked oxidase domain protein
F1734_08520	COG0640	Transcriptional regulator
F1734_08530	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F1734_08535	COG1074	ATP-dependent DNA helicase activity
F1734_08540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1734_08545	COG2072	flavoprotein involved in K transport
F1734_08555	COG0390	transport system, permease component
F1734_08560	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_08575	COG1793	dna ligase
F1734_08580	COG3842	ATPase activity
F1734_08585	COG0395	ABC-type sugar transport system, permease component
F1734_08590	COG1175	transmembrane transport
F1734_08605	COG1063	alcohol dehydrogenase
F1734_08620	COG1070	Carbohydrate kinase
F1734_08630	COG0477	Major facilitator Superfamily
F1734_08635	COG1414	Transcriptional regulator
F1734_08640	COG3971	2-oxopent-4-enoate hydratase activity
F1734_08650	COG1942	4-Oxalocrotonate Tautomerase
F1734_08655	COG1960	acyl-CoA dehydrogenase activity
F1734_08720	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F1734_08755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F1734_08755	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F1734_08785	COG3663	DNA glycosylase
F1734_08795	COG3757	hydrolase, family 25
F1734_08800	COG0477	Major facilitator Superfamily
F1734_08815	COG1051	belongs to the nudix hydrolase family
F1734_08820	COG2154	pterin-4-alpha-carbinolamine dehydratase
F1734_08830	COG1217	gtp-binding protein TYPA
F1734_08835	COG0747	negative chemotaxis
F1734_08840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1734_08870	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1734_08890	COG1012	belongs to the aldehyde dehydrogenase family
F1734_08895	COG0506	proline dehydrogenase activity
F1734_08910	COG3835	regulator
F1734_08920	COG1113	amino acid transport
F1734_08925	COG2171	N-acyltransferase activity
F1734_08930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1734_08935	COG1611	Belongs to the LOG family
F1734_08940	COG1611	Belongs to the LOG family
F1734_08945	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_08950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1734_08955	COG0463	Glycosyl transferase, family 2
F1734_08965	COG0519	Catalyzes the synthesis of GMP from XMP
F1734_08980	COG0297	glycogen (starch) synthase activity
F1734_08985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F1734_08990	COG4122	O-methyltransferase activity
F1734_08995	COG1595	DNA-templated transcription, initiation
F1734_09000	COG5662	AntiSigma factor
F1734_09005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1734_09035	COG2239	Acts as a magnesium transporter
F1734_09100	COG3328	transposase activity
F1734_09140	COG2301	Belongs to the HpcH HpaI aldolase family
F1734_09175	COG0477	Major facilitator Superfamily
F1734_09190	COG0514	ATP-dependent DNA helicase (RecQ)
F1734_09210	COG0598	Magnesium transport protein CorA
F1734_09215	COG0613	PHP domain protein
F1734_09250	COG1309	transcriptional regulator
F1734_09255	COG0567	Dehydrogenase, E1 component
F1734_09255	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1734_09260	COG1132	(ABC) transporter
F1734_09295	COG0435	Glutathione S-transferase
F1734_09315	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_09320	COG1024	Enoyl-CoA hydratase
F1734_09325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F1734_09370	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
F1734_09395	COG2318	DinB family
F1734_09400	COG1132	(ABC) transporter
F1734_09405	COG3467	pyridoxamine 5'-phosphate
F1734_09420	COG0577	efflux transmembrane transporter activity
F1734_09420	COG1136	(ABC) transporter
F1734_09445	COG1929	Belongs to the glycerate kinase type-1 family
F1734_09450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1734_09455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_09470	COG3550	peptidyl-serine autophosphorylation
F1734_09500	COG1960	acyl-CoA dehydrogenase activity
F1734_09505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_09515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_09525	COG0477	Major facilitator Superfamily
F1734_09535	COG0477	Major facilitator Superfamily
F1734_09555	COG2267	carboxylic ester hydrolase activity
F1734_09570	COG0519	Catalyzes the synthesis of GMP from XMP
F1734_09570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1734_09580	COG0579	oxidoreductase
F1734_09585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1734_09590	COG2814	Major facilitator Superfamily
F1734_09595	COG1414	Transcriptional regulator
F1734_09605	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1734_09635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1734_09645	COG0439	Biotin carboxylase
F1734_09670	COG1063	alcohol dehydrogenase
F1734_09690	COG1074	ATP-dependent DNA helicase activity
F1734_09700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1734_09730	COG2313	pseudouridylate synthase activity
F1734_09750	COG0505	Belongs to the CarA family
F1734_09755	COG0492	ferredoxin-NADP+ reductase activity
F1734_09775	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
F1734_09795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1734_09815	COG1832	CoA-binding protein
F1734_09825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1734_09840	COG3971	2-oxopent-4-enoate hydratase activity
F1734_09845	COG1414	Transcriptional regulator
F1734_10000	COG1609	Transcriptional regulator
F1734_10005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_10015	COG0154	amidase activity
F1734_10020	COG2814	Major facilitator Superfamily
F1734_10025	COG1335	isochorismatase
F1734_10040	COG1172	Belongs to the binding-protein-dependent transport system permease family
F1734_10055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1734_10055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1734_10100	COG4552	Acetyltransferase involved in intracellular survival and related
F1734_10110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1734_10125	COG2326	polyphosphate kinase activity
F1734_10165	COG0183	Belongs to the thiolase family
F1734_10190	COG1022	Amp-dependent synthetase and ligase
F1734_10220	COG0657	acetylesterase activity
F1734_10230	COG1116	anion transmembrane transporter activity
F1734_10235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F1734_10240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F1734_10245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F1734_10245	COG0352	thiamine-phosphate diphosphorylase activity
F1734_10245	COG0351	phosphomethylpyrimidine kinase
F1734_10250	COG2272	Belongs to the type-B carboxylesterase lipase family
F1734_10285	COG0772	Belongs to the SEDS family
F1734_10325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1734_10330	COG3189	MarR family transcriptional regulator
F1734_10335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F1734_10360	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1734_10365	COG0022	dehydrogenase e1 component
F1734_10380	COG0183	Belongs to the thiolase family
F1734_10390	COG3135	benzoate transporter
F1734_10400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1734_10415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1734_10435	COG1024	Enoyl-CoA hydratase
F1734_10455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1734_10490	COG1218	3'(2'),5'-bisphosphate nucleotidase
F1734_10515	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F1734_10535	COG0019	diaminopimelate decarboxylase activity
F1734_10540	COG0460	homoserine dehydrogenase
F1734_10545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F1734_10560	COG0254	rRNA binding
F1734_10565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1734_10575	COG2890	protein-(glutamine-N5) methyltransferase activity
F1734_10585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1734_10595	COG0356	it plays a direct role in the translocation of protons across the membrane
F1734_10600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1734_10605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1734_10610	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1734_10615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1734_10620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1734_10625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1734_10645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1734_10685	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
F1734_10700	COG0346	lactoylglutathione lyase activity
F1734_10705	COG0183	Belongs to the thiolase family
F1734_10710	COG2409	Drug exporters of the RND superfamily
F1734_10725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F1734_10730	COG0366	Alpha amylase catalytic
F1734_10735	COG0058	SHG alpha-glucan phosphorylase activity
F1734_10745	COG0596	Alpha beta hydrolase
F1734_10775	COG1278	Cold shock
F1734_10785	COG1335	isochorismatase
F1734_10790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F1734_10795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F1734_10815	COG1234	tRNA 3'-trailer cleavage
F1734_10820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F1734_10825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1734_10855	COG0736	holo-[acyl-carrier-protein] synthase activity
F1734_10865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F1734_10885	COG1376	ErfK ybiS ycfS ynhG family protein
F1734_10910	COG1376	ErfK ybiS ycfS ynhG family protein
F1734_10925	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F1734_10930	COG0300	oxidoreductase activity
F1734_10935	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1734_10935	COG1902	pentaerythritol trinitrate reductase activity
F1734_10985	COG0596	Alpha beta hydrolase
F1734_10990	COG1309	transcriptional regulator
F1734_11010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1734_11020	COG0277	FAD linked oxidase domain protein
F1734_11055	COG0494	nUDIX hydrolase
F1734_11060	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_11100	COG3336	cytochrome c oxidase
F1734_11150	COG2902	Dehydrogenase
F1734_11155	COG0824	Thioesterase
F1734_11165	COG0366	Alpha amylase catalytic
F1734_11185	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F1734_11200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F1734_11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_11235	COG3453	Protein conserved in bacteria
F1734_11240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1734_11265	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1734_11270	COG0740	serine-type endopeptidase activity
F1734_11275	COG0740	serine-type endopeptidase activity
F1734_11285	COG0477	Major facilitator Superfamily
F1734_11290	COG1309	transcriptional regulator
F1734_11295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1734_11310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F1734_11330	COG0069	glutamate synthase activity
F1734_11335	COG2218	PFAM glutamate synthase alpha subunit domain protein
F1734_11340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F1734_11360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1734_11415	COG4946	Tricorn protease homolog
F1734_11415	COG1506	peptidase
F1734_11415	COG0823	Involved in the tonB-independent uptake of proteins
F1734_11425	COG0525	valine-tRNA ligase activity
F1734_11430	COG0285	dihydrofolate synthase activity
F1734_11445	COG1530	ribonuclease E activity
F1734_11445	COG1530	ribonuclease E activity
F1734_11455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1734_11460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1734_11475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1734_11480	COG1917	Cupin 2, conserved barrel domain protein
F1734_11485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F1734_11490	COG0456	acetyltransferase
F1734_11495	COG0514	ATP-dependent DNA helicase (RecQ)
F1734_11525	COG1024	Enoyl-CoA hydratase
F1734_11530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1734_11535	COG1461	Dihydroxyacetone kinase
F1734_11540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1734_11545	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F1734_11550	COG0742	ribosomal rna small subunit methyltransferase
F1734_11555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1734_11570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F1734_11575	COG0571	ribonuclease III activity
F1734_11580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F1734_11590	COG4221	oxidoreductase activity
F1734_11600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F1734_11615	COG1131	(ABC) transporter
F1734_11630	COG1131	(ABC) transporter
F1734_11635	COG1309	transcriptional regulator
F1734_11645	COG3485	protocatechuate 3,4-dioxygenase
F1734_11650	COG3485	protocatechuate 3,4-dioxygenase
F1734_11655	COG0583	DNA-binding transcription factor activity
F1734_11670	COG1254	Belongs to the acylphosphatase family
F1734_11695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F1734_11715	COG0228	four-way junction DNA binding
F1734_11725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F1734_11730	COG0336	Belongs to the RNA methyltransferase TrmD family
F1734_11770	COG0792	nuclease activity
F1734_11795	COG2814	Major facilitator Superfamily
F1734_11800	COG4974	Belongs to the 'phage' integrase family
F1734_11820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1734_11825	COG0528	UMP kinase activity
F1734_11830	COG0233	cytoplasmic translational termination
F1734_11835	COG0575	Belongs to the CDS family
F1734_11845	COG2301	Belongs to the HpcH HpaI aldolase family
F1734_11855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1734_11865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F1734_11885	COG0768	penicillin binding
F1734_11890	COG2197	response regulator
F1734_11895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_11920	COG0579	oxidoreductase
F1734_11925	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_11930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F1734_11930	COG1648	precorrin-2 dehydrogenase activity
F1734_11945	COG3022	response to hydroperoxide
F1734_11950	COG0442	prolyl-tRNA aminoacylation
F1734_11955	COG4122	O-methyltransferase activity
F1734_11985	COG0481	GTPase activity
F1734_11985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1734_11995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F1734_12000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F1734_12010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F1734_12020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1734_12040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1734_12045	COG1121	(ABC) transporter
F1734_12065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1734_12100	COG1140	nitrate reductase beta subunit
F1734_12115	COG0612	Peptidase, M16
F1734_12120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1734_12145	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
F1734_12155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F1734_12165	COG1674	ftsk spoiiie
F1734_12180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F1734_12190	COG1546	Belongs to the CinA family
F1734_12190	COG1058	Belongs to the CinA family
F1734_12195	COG1396	sequence-specific DNA binding
F1734_12200	COG1842	Phage shock protein A
F1734_12210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F1734_12215	COG1122	ATPase activity
F1734_12220	COG1268	BioY protein
F1734_12225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F1734_12230	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1734_12260	COG1902	pentaerythritol trinitrate reductase activity
F1734_12280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1734_12285	COG2137	regulation of response to DNA damage stimulus
F1734_12290	COG0765	amino acid transport
F1734_12295	COG0765	amino acid transport
F1734_12300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1734_12305	COG1126	abc transporter atp-binding protein
F1734_12310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1734_12320	COG1196	nuclear chromosome segregation
F1734_12330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F1734_12340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F1734_12355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1734_12355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F1734_12355	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F1734_12365	COG1349	DNA-binding transcription factor activity
F1734_12370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1734_12375	COG2233	PERMEase
F1734_12380	COG1960	acyl-CoA dehydrogenase activity
F1734_12390	COG1388	LysM domain
F1734_12400	COG1643	Atp-dependent helicase
F1734_12405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1734_12450	COG4581	dead DEAH box helicase
F1734_12485	COG0123	including yeast histone deacetylase and acetoin utilization protein
F1734_12490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F1734_12490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F1734_12500	COG2890	protein-(glutamine-N5) methyltransferase activity
F1734_12540	COG0475	glutathione-regulated potassium exporter activity
F1734_12555	COG0483	inositol monophosphate 1-phosphatase activity
F1734_12575	COG0756	dUTP diphosphatase activity
F1734_12605	COG0569	domain protein
F1734_12610	COG0531	amino acid
F1734_12615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1734_12620	COG1846	Transcriptional regulator
F1734_12625	COG0477	Major facilitator Superfamily
F1734_12640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1734_12645	COG0477	Major facilitator Superfamily
F1734_12650	COG1024	Enoyl-CoA hydratase
F1734_12650	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1734_12655	COG0183	Belongs to the thiolase family
F1734_12680	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F1734_12710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F1734_12780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1734_12800	COG0438	transferase activity, transferring glycosyl groups
F1734_12810	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F1734_12820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F1734_12830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F1734_12835	COG0632	four-way junction helicase activity
F1734_12840	COG2255	four-way junction helicase activity
F1734_12860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1734_12865	COG0747	negative chemotaxis
F1734_12870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F1734_12875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F1734_12885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F1734_12900	COG0124	histidyl-tRNA synthetase
F1734_12920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1734_12935	COG0484	heat shock protein binding
F1734_12940	COG1473	amidohydrolase
F1734_12940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1734_12975	COG1984	allophanate hydrolase subunit 2
F1734_12985	COG1113	amino acid transport
F1734_12995	COG1366	Belongs to the anti-sigma-factor antagonist family
F1734_13000	COG1215	transferase activity, transferring glycosyl groups
F1734_13005	COG2208	phosphoserine phosphatase activity
F1734_13010	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
F1734_13010	COG4124	Belongs to the glycosyl hydrolase 26 family
F1734_13015	COG2072	flavoprotein involved in K transport
F1734_13040	COG0789	Transcriptional regulator
F1734_13070	COG0210	DNA helicase
F1734_13075	COG1201	RNA secondary structure unwinding
F1734_13115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1734_13125	COG0513	Belongs to the DEAD box helicase family
F1734_13170	COG3795	YCII-related domain
F1734_13175	COG4941	Belongs to the sigma-70 factor family
F1734_13210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1734_13250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1734_13255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F1734_13265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1734_13295	COG0477	Major facilitator Superfamily
F1734_13325	COG0121	glutamine amidotransferase
F1734_13335	COG3387	PFAM Glycoside hydrolase 15-related
F1734_13345	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_13370	COG3246	L-lysine catabolic process to acetate
F1734_13375	COG2175	clavaminate synthase activity
F1734_13395	COG4941	Belongs to the sigma-70 factor family
F1734_13410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1734_13415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1734_13425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1734_13460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1734_13470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F1734_13475	COG0540	Belongs to the ATCase OTCase family
F1734_13490	COG0505	Belongs to the CarA family
F1734_13495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F1734_13500	COG0284	orotidine-5'-phosphate decarboxylase activity
F1734_13510	COG0194	GDP metabolic process
F1734_13515	COG1758	RNA polymerase activity
F1734_13525	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1734_13560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1734_13560	COG0574	Belongs to the PEP-utilizing enzyme family
F1734_13580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1734_13580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1734_13595	COG0322	excinuclease ABC activity
F1734_13600	COG1660	Displays ATPase and GTPase activities
F1734_13610	COG1481	regulation of sporulation
F1734_13615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1734_13620	COG0126	phosphoglycerate kinase activity
F1734_13625	COG0149	triose-phosphate isomerase activity
F1734_13635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F1734_13645	COG2015	COG2015, Alkyl sulfatase and related hydrolases
F1734_13670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1734_13680	COG0109	protoheme IX farnesyltransferase activity
F1734_13705	COG1131	(ABC) transporter
F1734_13730	COG0396	ATPase activity
F1734_13745	COG2151	metal-sulfur cluster biosynthetic enzyme
F1734_13755	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F1734_13780	COG1309	transcriptional regulator
F1734_13785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F1734_13795	COG0791	NLP P60 protein
F1734_13795	COG3883	PFAM NLP P60 protein
F1734_13800	COG0714	Associated with various cellular activities
F1734_13810	COG2304	oxidoreductase activity
F1734_13815	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_13820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F1734_13825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F1734_13885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_13890	COG0730	response to heat
F1734_13895	COG3268	Saccharopine dehydrogenase
F1734_13930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F1734_13960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F1734_13965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1734_13975	COG5398	heme oxygenase
F1734_13980	COG0667	Aldo Keto reductase
F1734_13985	COG1968	undecaprenyl-diphosphatase activity
F1734_14005	COG0215	cysteine-tRNA ligase activity
F1734_14065	COG1201	RNA secondary structure unwinding
F1734_14115	COG2146	nitrite reductase [NAD(P)H] activity
F1734_14120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1734_14135	COG1410	methionine synthase
F1734_14135	COG0646	methionine synthase
F1734_14140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1734_14145	COG1054	Belongs to the UPF0176 family
F1734_14150	COG0564	pseudouridine synthase activity
F1734_14155	COG0140	phosphoribosyl-ATP diphosphatase activity
F1734_14225	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
F1734_14240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1734_14250	COG4581	dead DEAH box helicase
F1734_14275	COG0300	oxidoreductase activity
F1734_14280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1734_14315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1734_14325	COG0463	Glycosyl transferase, family 2
F1734_14345	COG0287	Prephenate dehydrogenase
F1734_14350	COG0512	Glutamine amidotransferase of anthranilate synthase
F1734_14350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1734_14380	COG0346	lactoylglutathione lyase activity
F1734_14395	COG1252	NADH dehydrogenase
F1734_14410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1734_14415	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1734_14420	COG1120	ATPase activity
F1734_14435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F1734_14440	COG0697	spore germination
F1734_14450	COG1253	flavin adenine dinucleotide binding
F1734_14455	COG1253	flavin adenine dinucleotide binding
F1734_14470	COG0277	FAD linked oxidase domain protein
F1734_14480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F1734_14490	COG1408	metallophosphoesterase
F1734_14515	COG1716	ATPase activity
F1734_14545	COG0494	nUDIX hydrolase
F1734_14550	COG0714	Associated with various cellular activities
F1734_14565	COG1454	alcohol dehydrogenase
F1734_14565	COG1012	belongs to the aldehyde dehydrogenase family
F1734_14585	COG1160	GTP binding
F1734_14590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1734_14595	COG1187	pseudouridine synthase activity
F1734_14600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1734_14605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F1734_14620	COG0494	nUDIX hydrolase
F1734_14625	COG0504	CTP synthase activity
F1734_14645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1734_14655	COG0647	UMP catabolic process
F1734_14680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1734_14685	COG2094	Belongs to the DNA glycosylase MPG family
F1734_14700	COG0165	Argininosuccinate lyase
F1734_14710	COG1438	arginine binding
F1734_14725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1734_14730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1734_14735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1734_14745	COG0072	phenylalanine-tRNA ligase activity
F1734_14745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1734_14750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1734_14760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1734_14780	COG0469	pyruvate kinase activity
F1734_14865	COG3328	transposase activity
F1734_14955	COG0604	alcohol dehydrogenase
F1734_14955	COG3321	synthase
F1734_14960	COG1012	belongs to the aldehyde dehydrogenase family
F1734_14975	COG2267	carboxylic ester hydrolase activity
F1734_15020	COG0713	ATP synthesis coupled electron transport
F1734_15030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F1734_15030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1734_15035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F1734_15040	COG1034	ATP synthesis coupled electron transport
F1734_15055	COG0649	NAD binding
F1734_15060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1734_15065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1734_15080	COG0659	secondary active sulfate transmembrane transporter activity
F1734_15135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F1734_15135	COG0237	dephospho-CoA kinase activity
F1734_15145	COG0539	negative regulation of cytoplasmic translation
F1734_15155	COG3548	integral membrane protein
F1734_15160	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_15175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1734_15185	COG0473	3-isopropylmalate dehydrogenase activity
F1734_15195	COG4977	sequence-specific DNA binding
F1734_15200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1734_15250	COG2124	cytochrome p450
F1734_15260	COG1414	Transcriptional regulator
F1734_15300	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1734_15300	COG0022	dehydrogenase e1 component
F1734_15305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1734_15310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_15325	COG0604	alcohol dehydrogenase
F1734_15335	COG1946	Acyl-CoA thioesterase
F1734_15345	COG0789	Transcriptional regulator
F1734_15350	COG0783	Belongs to the Dps family
F1734_15355	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F1734_15375	COG0067	glutamate synthase
F1734_15375	COG0069	glutamate synthase activity
F1734_15375	COG0070	glutamate synthase
F1734_15385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1734_15410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1734_15420	COG3384	dioxygenase
F1734_15450	COG0107	imidazoleglycerol-phosphate synthase activity
F1734_15455	COG0483	inositol monophosphate 1-phosphatase activity
F1734_15470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1734_15480	COG0131	Imidazoleglycerol-phosphate dehydratase
F1734_15490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1734_15500	COG3243	poly(R)-hydroxyalkanoic acid synthase
F1734_15515	COG2723	6-phospho-beta-galactosidase activity
F1734_15520	COG1280	lysine exporter protein (LysE YggA)
F1734_15535	COG0157	Belongs to the NadC ModD family
F1734_15555	COG1733	regulation of RNA biosynthetic process
F1734_15570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1734_15585	COG1053	succinate dehydrogenase
F1734_15620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F1734_15625	COG0156	8-amino-7-oxononanoate synthase activity
F1734_15630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F1734_15695	COG3012	SEC-C Motif Domain Protein
F1734_15720	COG1309	transcriptional regulator
F1734_15730	COG0477	Major facilitator Superfamily
F1734_15790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1734_15815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1734_15825	COG3599	regulation of cell shape
F1734_15835	COG1799	cell septum assembly
F1734_15850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F1734_15855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F1734_15860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1734_15875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F1734_15895	COG0768	penicillin binding
F1734_15910	COG2001	Belongs to the MraZ family
F1734_15945	COG0463	Glycosyl transferase, family 2
F1734_15955	COG0142	geranyltranstransferase activity
F1734_15985	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F1734_16000	COG1940	carbohydrate kinase activity
F1734_16010	COG0003	Pfam Anion-transporting ATPase
F1734_16025	COG0438	transferase activity, transferring glycosyl groups
F1734_16040	COG0791	NLP P60 protein
F1734_16055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1734_16065	COG1845	cytochrome c oxidase, subunit III
F1734_16105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F1734_16115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F1734_16135	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F1734_16140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F1734_16145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1734_16150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F1734_16155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F1734_16170	COG0321	lipoyl(octanoyl) transferase activity
F1734_16175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1734_16190	COG0174	glutamine synthetase
F1734_16210	COG0531	amino acid
F1734_16220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1734_16235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F1734_16240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F1734_16245	COG0174	glutamine synthetase
F1734_16255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F1734_16335	COG1022	Amp-dependent synthetase and ligase
F1734_16375	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F1734_16390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1734_16425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F1734_16435	COG1595	DNA-templated transcription, initiation
F1734_16445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1734_16470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F1734_16485	COG0423	glycine-tRNA ligase activity
F1734_16510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1734_16515	COG1381	Involved in DNA repair and RecF pathway recombination
F1734_16550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F1734_16565	COG0477	Major facilitator Superfamily
F1734_16580	COG0484	heat shock protein binding
F1734_16585	COG1420	regulation of RNA biosynthetic process
F1734_16625	COG0589	response to stress
F1734_16640	COG3387	PFAM Glycoside hydrolase 15-related
F1734_16645	COG2070	2-Nitropropane dioxygenase
F1734_16650	COG0481	GTPase activity
F1734_16660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F1734_16665	COG0268	Binds directly to 16S ribosomal RNA
F1734_16680	COG2183	response to ionizing radiation
F1734_16690	COG2755	lipolytic protein G-D-S-L family
F1734_16695	COG0406	alpha-ribazole phosphatase activity
F1734_16700	COG0799	negative regulation of ribosome biogenesis
F1734_16705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1734_16715	COG0542	response to heat
F1734_16720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F1734_16730	COG0626	cystathionine gamma-synthase activity
F1734_16735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1734_16740	COG1920	GTP binding
F1734_16745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F1734_16760	COG0066	3-isopropylmalate dehydratase activity
F1734_16765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1734_16795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1734_16800	COG0179	Fumarylacetoacetate (FAA) hydrolase
F1734_16805	COG2271	Major facilitator Superfamily
F1734_16825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1734_16830	COG0440	acetolactate synthase activity
F1734_16845	COG0129	dihydroxy-acid dehydratase activity
F1734_16870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1734_16880	COG2197	response regulator
F1734_16900	COG0154	amidase activity
F1734_16905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1734_16920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1734_16930	COG0482	sulfurtransferase activity
F1734_16950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F1734_16960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1734_16980	COG0110	maltose O-acetyltransferase activity
F1734_16985	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1734_16990	COG0346	lactoylglutathione lyase activity
F1734_16995	COG0640	Transcriptional regulator
F1734_17005	COG2226	methyltransferase
F1734_17020	COG1119	ATPase activity
F1734_17035	COG3830	Belongs to the UPF0237 family
F1734_17035	COG0560	Phosphoserine phosphatase
F1734_17040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1734_17065	COG1780	Probably involved in ribonucleotide reductase function
F1734_17075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F1734_17080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F1734_17085	COG2080	2 iron, 2 sulfur cluster binding
F1734_17090	COG0431	NADPH-dependent FMN reductase
F1734_17095	COG1309	transcriptional regulator
F1734_17125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1734_17135	COG0315	cyclic pyranopterin monophosphate synthase activity
F1734_17135	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1734_17140	COG0314	molybdopterin synthase activity
F1734_17145	COG0513	Belongs to the DEAD box helicase family
F1734_17175	COG3265	gluconokinase activity
F1734_17180	COG2197	response regulator
F1734_17185	COG1414	Transcriptional regulator
F1734_17220	COG0477	Major facilitator Superfamily
F1734_17230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1734_17235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F1734_17560	COG0582	viral genome integration into host DNA
F1734_17575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1734_17580	COG2177	Part of the ABC transporter FtsEX involved in
F1734_17585	COG2884	Cell division ATP-binding protein ftsE
F1734_17595	COG0668	transmembrane transport
F1734_17600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F1734_17605	COG0483	inositol monophosphate 1-phosphatase activity
F1734_17615	COG1960	acyl-CoA dehydrogenase activity
F1734_17625	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_17635	COG1388	LysM domain
F1734_17640	COG1615	UPF0182 protein
F1734_17650	COG3480	Lon protease (S16) C-terminal proteolytic domain
F1734_17665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F1734_17680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F1734_17685	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_17730	COG0596	Alpha beta hydrolase
F1734_17735	COG3695	enzyme binding
F1734_17745	COG0746	molybdenum cofactor guanylyltransferase activity
F1734_17750	COG1289	transmembrane transporter activity
F1734_17770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1734_17770	COG2146	nitrite reductase [NAD(P)H] activity
F1734_17785	COG2186	Transcriptional regulator
F1734_17820	COG0513	Belongs to the DEAD box helicase family
F1734_17845	COG1597	lipid kinase activity
F1734_17860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F1734_17880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F1734_17885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F1734_17890	COG1162	GTPase activity
F1734_17935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F1734_17940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1734_17945	COG5401	PFAM Sporulation and spore germination
F1734_17950	COG5002	protein histidine kinase activity
F1734_17955	COG0745	RESPONSE REGULATOR receiver
F1734_17975	COG1482	cell wall glycoprotein biosynthetic process
F1734_17985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1734_18005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F1734_18010	COG0778	Nitroreductase
F1734_18010	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
F1734_18020	COG2755	lipolytic protein G-D-S-L family
F1734_18025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F1734_18035	COG1091	dTDP-4-dehydrorhamnose reductase activity
F1734_18040	COG1316	TRANSCRIPTIONal
F1734_18060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F1734_18070	COG2205	protein histidine kinase activity
F1734_18090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1734_18100	COG0424	maF-like protein
F1734_18105	COG2226	methyltransferase
F1734_18135	COG4770	biotin carboxylase activity
F1734_18165	COG2365	Tyrosine phosphatase family
F1734_18180	COG1522	sequence-specific DNA binding
F1734_18185	COG1012	belongs to the aldehyde dehydrogenase family
F1734_18210	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_18215	COG0277	FAD linked oxidase domain protein
F1734_18225	COG1201	RNA secondary structure unwinding
F1734_18255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F1734_18280	COG3842	ATPase activity
F1734_18290	COG1840	ABC-type Fe3 transport system, periplasmic component
F1734_18295	COG1473	amidohydrolase
F1734_18295	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1734_18315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1734_18325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F1734_18330	COG1174	glycine betaine transport
F1734_18335	COG0517	IMP dehydrogenase activity
F1734_18335	COG1125	glycine betaine transport
F1734_18340	COG1174	glycine betaine transport
F1734_18350	COG2076	Multidrug Resistance protein
F1734_18360	COG0791	NLP P60 protein
F1734_18405	COG2009	succinate dehydrogenase
F1734_18415	COG1053	succinate dehydrogenase
F1734_18420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F1734_18425	COG1064	alcohol dehydrogenase
F1734_18430	COG2130	NADP-dependent
F1734_18435	COG1309	transcriptional regulator
F1734_18440	COG1295	ribonuclease BN
F1734_18445	COG0180	Tryptophanyl-tRNA synthetase
F1734_18450	COG0708	Exodeoxyribonuclease III
F1734_18460	COG2873	o-acetylhomoserine
F1734_18465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1734_18475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1734_18480	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F1734_18485	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F1734_18505	COG0587	DNA-directed DNA polymerase activity
F1734_18510	COG1595	DNA-templated transcription, initiation
F1734_18525	COG2132	Multicopper oxidase
F1734_18530	COG1131	(ABC) transporter
F1734_18535	COG3559	Exporter of polyketide antibiotics
F1734_18600	COG2815	serine threonine protein kinase
F1734_18600	COG0515	serine threonine protein kinase
F1734_18605	COG0789	Transcriptional regulator
F1734_18625	COG1983	PspC domain protein
F1734_18635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F1734_18635	COG0519	Catalyzes the synthesis of GMP from XMP
F1734_18645	COG0516	GMP reductase activity
F1734_18680	COG0459	protein refolding
F1734_18685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1734_18695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F1734_18700	COG0456	acetyltransferase
F1734_18715	COG2267	carboxylic ester hydrolase activity
F1734_18720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F1734_18730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1734_18750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1734_18755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F1734_18785	COG1674	ftsk spoiiie
F1734_18795	COG1404	Belongs to the peptidase S8 family
F1734_18800	COG3266	domain, Protein
F1734_18820	COG1960	acyl-CoA dehydrogenase activity
F1734_18830	COG0101	tRNA pseudouridine synthase activity
F1734_18835	COG0203	ribosomal protein L17
F1734_18840	COG0202	RNA polymerase activity
F1734_18860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1734_18865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1734_18880	COG0563	adenylate kinase activity
F1734_18900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1734_18905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1734_18910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1734_18915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1734_18925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1734_18930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1734_18935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F1734_18940	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1734_18955	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1734_18965	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1734_18970	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1734_18975	COG0089	rRNA binding
F1734_18980	COG0088	Forms part of the polypeptide exit tunnel
F1734_18990	COG0051	transcription antitermination factor activity, RNA binding
F1734_18995	COG0154	amidase activity
F1734_19030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_19035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_19040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_19045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_19055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_19075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_19095	COG1960	acyl-CoA dehydrogenase activity
F1734_19105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1734_19125	COG1012	belongs to the aldehyde dehydrogenase family
F1734_19135	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_19140	COG0477	Major facilitator Superfamily
F1734_19160	COG4303	Ethanolamine ammonia lyase large subunit
F1734_19165	COG0531	amino acid
F1734_19210	COG3795	YCII-related domain
F1734_19215	COG4941	Belongs to the sigma-70 factor family
F1734_19265	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1734_19265	COG1902	pentaerythritol trinitrate reductase activity
F1734_19275	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1734_19275	COG1902	pentaerythritol trinitrate reductase activity
F1734_19290	COG0535	radical SAM domain protein
F1734_19310	COG3559	Exporter of polyketide antibiotics
F1734_19315	COG1131	(ABC) transporter
F1734_19325	COG2197	response regulator
F1734_19335	COG1454	alcohol dehydrogenase
F1734_19385	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F1734_19395	COG1302	Protein conserved in bacteria
F1734_19420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1734_19425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1734_19430	COG0049	tRNA binding
F1734_19435	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F1734_19455	COG1309	transcriptional regulator
F1734_19475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F1734_19495	COG5006	permease, DMT superfamily
F1734_19500	COG0477	Major facilitator Superfamily
F1734_19505	COG0583	DNA-binding transcription factor activity
F1734_19520	COG2149	membrane
F1734_19525	COG0723	plastoquinol--plastocyanin reductase activity
F1734_19545	COG0477	Major facilitator Superfamily
F1734_19565	COG4607	ABC-type enterochelin transport system periplasmic component
F1734_19570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1734_19620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1734_19625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1734_19640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1734_19645	COG0081	regulation of translation
F1734_19660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F1734_19700	COG1666	GTP binding
F1734_19705	COG0501	Belongs to the peptidase M48B family
F1734_19710	COG0142	geranyltranstransferase activity
F1734_19720	COG2226	methyltransferase
F1734_19725	COG0438	transferase activity, transferring glycosyl groups
F1734_19735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F1734_19740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1734_19755	COG4948	Mandelate Racemase Muconate Lactonizing
F1734_19835	COG1950	PFAM Membrane protein of
F1734_19855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1734_19880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F1734_19890	COG0785	Cytochrome C biogenesis protein
F1734_19895	COG0386	Belongs to the glutathione peroxidase family
F1734_19900	COG0406	alpha-ribazole phosphatase activity
F1734_19905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1734_19920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
F1734_19940	COG2133	pyrroloquinoline quinone binding
F1734_19945	COG1937	Protein conserved in bacteria
F1734_19965	COG1648	precorrin-2 dehydrogenase activity
F1734_19965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F1734_19970	COG0181	hydroxymethylbilane synthase activity
F1734_19975	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1734_20040	COG1082	Xylose isomerase domain protein TIM barrel
F1734_20060	COG0745	RESPONSE REGULATOR receiver
F1734_20065	COG5002	protein histidine kinase activity
F1734_20070	COG0588	phosphoglycerate mutase activity
F1734_20075	COG0493	'glutamate synthase
F1734_20080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F1734_20085	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_20100	COG1652	LysM domain
F1734_20110	COG0438	transferase activity, transferring glycosyl groups
F1734_20115	COG1733	regulation of RNA biosynthetic process
F1734_20135	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F1734_20170	COG2814	Major facilitator Superfamily
F1734_20185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F1734_20215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F1734_20235	COG0788	formyltetrahydrofolate deformylase activity
F1734_20245	COG2267	carboxylic ester hydrolase activity
F1734_20270	COG2733	membrane
F1734_20285	COG2326	polyphosphate kinase activity
F1734_20300	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_20320	COG2890	protein-(glutamine-N5) methyltransferase activity
F1734_20350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1734_20350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1734_20395	COG0693	protein deglycase activity
F1734_20400	COG3707	response regulator
F1734_20455	COG1064	alcohol dehydrogenase
F1734_20460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F1734_20470	COG2224	Isocitrate lyase
F1734_20480	COG1017	nitric oxide dioxygenase activity
F1734_20480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F1734_20520	COG1802	Transcriptional regulator
F1734_20530	COG1802	Transcriptional regulator
F1734_20575	COG3293	Transposase
F1734_20585	COG1505	serine-type exopeptidase activity
F1734_20630	COG0647	UMP catabolic process
F1734_20635	COG0326	Molecular chaperone. Has ATPase activity
F1734_20640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F1734_20645	COG1228	amidohydrolase
F1734_20655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F1734_20660	COG2986	histidine ammonia-lyase
F1734_20680	COG0688	phosphatidylethanolamine metabolic process
F1734_20690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1734_20700	COG2816	NAD+ diphosphatase activity
F1734_20705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1734_20705	COG2111	Na H antiporter
F1734_20710	COG1006	Multisubunit Na H antiporter MnhC subunit
F1734_20715	COG0651	ATP synthesis coupled electron transport
F1734_20740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1734_20780	COG0351	phosphomethylpyrimidine kinase
F1734_20790	COG2234	aminopeptidase activity
F1734_20800	COG1131	(ABC) transporter
F1734_20810	COG2022	thiamine diphosphate biosynthetic process
F1734_20825	COG0352	thiamine-phosphate diphosphorylase activity
F1734_20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F1734_20850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F1734_20855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F1734_20865	COG3485	protocatechuate 3,4-dioxygenase
F1734_20885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_20905	COG3284	Transcriptional regulator
F1734_20920	COG0145	ligase activity
F1734_20925	COG4647	ligase activity
F1734_20930	COG0145	ligase activity
F1734_20960	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F1734_20965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1734_20970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1734_20975	COG2354	Protein conserved in bacteria
F1734_20985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1734_21005	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F1734_21010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1734_21025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_21040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1734_21070	COG0438	transferase activity, transferring glycosyl groups
F1734_21075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1734_21090	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_21165	COG1797	cobyrinic acid a,c-diamide synthase activity
F1734_21210	COG4129	membrane
F1734_21235	COG0586	Pfam SNARE associated Golgi protein
F1734_21240	COG0523	cobalamin synthesis protein
F1734_21275	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F1734_21310	COG0542	response to heat
F1734_21325	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_21335	COG1053	succinate dehydrogenase
F1734_21350	COG0346	lactoylglutathione lyase activity
F1734_21365	COG3631	Ketosteroid isomerase-related protein
F1734_21375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1734_21380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_21385	COG0789	Transcriptional regulator
F1734_21390	COG0484	heat shock protein binding
F1734_21395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1734_21400	COG0443	Heat shock 70 kDa protein
F1734_21430	COG0443	Heat shock 70 kDa protein
F1734_21460	COG0247	lactate metabolic process
F1734_21460	COG2181	nitrate reductase activity
F1734_21470	COG3239	Fatty acid desaturase
F1734_21490	COG0745	RESPONSE REGULATOR receiver
F1734_21495	COG4251	negative regulation of phosphorylation
F1734_21500	COG0784	Response regulator, receiver
F1734_21515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1734_21520	COG0489	protein tyrosine kinase activity
F1734_21525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F1734_21540	COG1045	serine acetyltransferase
F1734_21555	COG0297	glycogen (starch) synthase activity
F1734_21570	COG0438	transferase activity, transferring glycosyl groups
F1734_21575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F1734_21585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1734_21590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F1734_21595	COG1482	cell wall glycoprotein biosynthetic process
F1734_21600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F1734_21650	COG2814	Major facilitator Superfamily
F1734_21705	COG2814	Major facilitator Superfamily
F1734_21715	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F1734_21755	COG2337	Toxic component of a toxin-antitoxin (TA) module
F1734_21770	COG0248	Ppx GppA phosphatase
F1734_21775	COG1546	Belongs to the CinA family
F1734_21775	COG1058	Belongs to the CinA family
F1734_21780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F1734_21790	COG1414	Transcriptional regulator
F1734_21795	COG1309	transcriptional regulator
F1734_21810	COG4221	oxidoreductase activity
F1734_21850	COG1309	transcriptional regulator
F1734_21865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F1734_21870	COG1960	acyl-CoA dehydrogenase activity
F1734_21875	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_21905	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_21910	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_21920	COG2197	response regulator
F1734_21925	COG2223	nitrite transmembrane transporter activity
F1734_21935	COG1960	acyl-CoA dehydrogenase activity
F1734_21940	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_21945	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_21965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_21990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F1734_21995	COG0697	spore germination
F1734_22000	COG1024	Enoyl-CoA hydratase
F1734_22015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1734_22020	COG0427	acetyl-CoA hydrolase
F1734_22025	COG0183	Belongs to the thiolase family
F1734_22030	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_22045	COG2186	Transcriptional regulator
F1734_22050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_22055	COG1960	acyl-CoA dehydrogenase activity
F1734_22060	COG2030	dehydratase
F1734_22070	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_22075	COG1024	Enoyl-CoA hydratase
F1734_22085	COG2197	response regulator
F1734_22090	COG0633	Ferredoxin
F1734_22130	COG2197	response regulator
F1734_22145	COG0633	Ferredoxin
F1734_22170	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_22175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1734_22180	COG2159	amidohydrolase
F1734_22190	COG3384	dioxygenase
F1734_22195	COG2267	carboxylic ester hydrolase activity
F1734_22225	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_22235	COG4608	Belongs to the ABC transporter superfamily
F1734_22245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1734_22260	COG0747	negative chemotaxis
F1734_22270	COG2267	carboxylic ester hydrolase activity
F1734_22275	COG3467	pyridoxamine 5'-phosphate
F1734_22280	COG1752	Esterase of the alpha-beta hydrolase superfamily
F1734_22310	COG0659	secondary active sulfate transmembrane transporter activity
F1734_22335	COG2855	membrane
F1734_22360	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_22365	COG1960	acyl-CoA dehydrogenase activity
F1734_22370	COG2175	clavaminate synthase activity
F1734_22375	COG3246	L-lysine catabolic process to acetate
F1734_22380	COG2814	Major facilitator Superfamily
F1734_22385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1734_22405	COG0640	Transcriptional regulator
F1734_22410	COG2814	Major facilitator Superfamily
F1734_22415	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
F1734_22435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_22445	COG1012	belongs to the aldehyde dehydrogenase family
F1734_22450	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_22460	COG2072	flavoprotein involved in K transport
F1734_22465	COG1309	transcriptional regulator
F1734_22480	COG2902	Dehydrogenase
F1734_22520	COG1012	belongs to the aldehyde dehydrogenase family
F1734_22540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1734_22545	COG2957	Belongs to the agmatine deiminase family
F1734_22555	COG0174	glutamine synthetase
F1734_22570	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_22585	COG0183	Belongs to the thiolase family
F1734_22595	COG1960	acyl-CoA dehydrogenase activity
F1734_22605	COG1960	acyl-CoA dehydrogenase activity
F1734_22610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_22620	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_22630	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_22635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1734_22650	COG2030	dehydratase
F1734_22660	COG1960	acyl-CoA dehydrogenase activity
F1734_22665	COG0183	Belongs to the thiolase family
F1734_22670	COG1309	transcriptional regulator
F1734_22675	COG1960	acyl-CoA dehydrogenase activity
F1734_22695	COG0346	lactoylglutathione lyase activity
F1734_22710	COG4569	acetaldehyde dehydrogenase (acetylating) activity
F1734_22715	COG3971	2-oxopent-4-enoate hydratase activity
F1734_22725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1734_22765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1734_22775	COG4166	transmembrane transport
F1734_22790	COG4948	Mandelate Racemase Muconate Lactonizing
F1734_22805	COG0151	Belongs to the GarS family
F1734_22820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_22830	COG3284	Transcriptional regulator
F1734_22840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F1734_22845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F1734_22850	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1734_22855	COG0022	dehydrogenase e1 component
F1734_22860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F1734_22905	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_23015	COG1357	PFAM Pentapeptide repeats (8 copies)
F1734_23070	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1734_23090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1734_23100	COG0500	methyltransferase
F1734_23105	COG1960	acyl-CoA dehydrogenase activity
F1734_23120	COG0183	Belongs to the thiolase family
F1734_23125	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_23130	COG2030	dehydratase
F1734_23135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F1734_23155	COG1309	transcriptional regulator
F1734_23160	COG1472	Belongs to the glycosyl hydrolase 3 family
F1734_23165	COG0589	response to stress
F1734_23180	COG4981	capsule polysaccharide biosynthetic process
F1734_23205	COG0438	transferase activity, transferring glycosyl groups
F1734_23240	COG1045	serine acetyltransferase
F1734_23255	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F1734_23275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1734_23285	COG2409	Drug exporters of the RND superfamily
F1734_23330	COG2353	YceI-like domain
F1734_23340	COG3104	oligopeptide transport
F1734_23360	COG0488	(ABC) transporter
F1734_23365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F1734_23385	COG0657	acetylesterase activity
F1734_23390	COG1960	acyl-CoA dehydrogenase activity
F1734_23425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F1734_23440	COG2188	Transcriptional regulator
F1734_23450	COG2301	Belongs to the HpcH HpaI aldolase family
F1734_23455	COG2030	dehydratase
F1734_23475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F1734_23495	COG1960	acyl-CoA dehydrogenase activity
F1734_23505	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_23510	COG1960	acyl-CoA dehydrogenase activity
F1734_23515	COG1024	Enoyl-CoA hydratase
F1734_23550	COG0596	Alpha beta hydrolase
F1734_23550	COG0508	dehydrogenase complex catalyzes the overall conversion of
F1734_23555	COG2135	peptidase activity
F1734_23560	COG0351	phosphomethylpyrimidine kinase
F1734_23600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1734_23610	COG3590	peptidase
F1734_23630	COG0028	Belongs to the TPP enzyme family
F1734_23655	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_23670	COG2205	protein histidine kinase activity
F1734_23680	COG0531	amino acid
F1734_23705	COG3852	Histidine kinase
F1734_23725	COG4638	Rieske (2fe-2S)
F1734_23735	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_23745	COG4566	intracellular signal transduction
F1734_23755	COG0154	amidase activity
F1734_23760	COG2271	Major facilitator Superfamily
F1734_23775	COG0243	molybdopterin cofactor binding
F1734_23780	COG0784	Response regulator, receiver
F1734_23795	COG0438	transferase activity, transferring glycosyl groups
F1734_23820	COG3842	ATPase activity
F1734_23825	COG1653	transport
F1734_23835	COG1175	transmembrane transport
F1734_23840	COG1376	ErfK ybiS ycfS ynhG family protein
F1734_23850	COG3360	Dodecin
F1734_23855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1734_23870	COG1793	dna ligase
F1734_23880	COG0598	Magnesium transport protein CorA
F1734_23900	COG0739	heme binding
F1734_23910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1734_23935	COG2217	Heavy metal translocating P-type atpase
F1734_23960	COG2132	Multicopper oxidase
F1734_23970	COG0745	RESPONSE REGULATOR receiver
F1734_23975	COG5002	protein histidine kinase activity
F1734_23990	COG1131	(ABC) transporter
F1734_23995	COG2197	response regulator
F1734_24000	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_24030	COG0667	Aldo Keto reductase
F1734_24040	COG0129	dihydroxy-acid dehydratase activity
F1734_24050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1734_24050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1734_24060	COG0425	Belongs to the sulfur carrier protein TusA family
F1734_24070	COG0243	molybdopterin cofactor binding
F1734_24090	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
F1734_24105	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F1734_24115	COG2873	o-acetylhomoserine
F1734_24130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1734_24135	COG0640	Transcriptional regulator
F1734_24140	COG0798	PFAM Bile acid sodium symporter
F1734_24145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1734_24150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1734_24160	COG2072	flavoprotein involved in K transport
F1734_24165	COG0167	dihydroorotate dehydrogenase activity
F1734_24170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F1734_24170	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F1734_24170	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1734_24170	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1734_24175	COG0493	'glutamate synthase
F1734_24185	COG0640	Transcriptional regulator
F1734_24195	COG4604	ABC transporter, ATP-binding protein
F1734_24200	COG4605	iron ion homeostasis
F1734_24205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1734_24210	COG4607	ABC-type enterochelin transport system periplasmic component
F1734_24215	COG0604	alcohol dehydrogenase
F1734_24240	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_24245	COG1024	Enoyl-CoA hydratase
F1734_24250	COG2267	carboxylic ester hydrolase activity
F1734_24295	COG1309	transcriptional regulator
F1734_24300	COG1250	3-hydroxyacyl-CoA dehydrogenase
F1734_24305	COG4716	Myosin-crossreactive antigen
F1734_24320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F1734_24360	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F1734_24400	COG2267	carboxylic ester hydrolase activity
F1734_24405	COG2161	toxin-antitoxin pair type II binding
F1734_24420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
F1734_24430	COG0328	RNA-DNA hybrid ribonuclease activity
F1734_24450	COG1063	alcohol dehydrogenase
F1734_24475	COG1309	transcriptional regulator
F1734_24480	COG0640	Transcriptional regulator
F1734_24510	COG3185	4-Hydroxyphenylpyruvate dioxygenase
F1734_24520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F1734_24525	COG1113	amino acid transport
F1734_24535	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_24540	COG0183	Belongs to the thiolase family
F1734_24545	COG1960	acyl-CoA dehydrogenase activity
F1734_24605	COG1556	Lactate utilization protein
F1734_24610	COG1139	Iron-sulfur cluster binding protein
F1734_24615	COG0247	lactate metabolic process
F1734_24620	COG1620	l-lactate permease
F1734_24635	COG0628	permease
F1734_24665	COG3485	protocatechuate 3,4-dioxygenase
F1734_24670	COG3485	protocatechuate 3,4-dioxygenase
F1734_24680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F1734_24685	COG1414	Transcriptional regulator
F1734_24690	COG0183	Belongs to the thiolase family
F1734_24695	COG2271	Major facilitator Superfamily
F1734_24765	COG1012	belongs to the aldehyde dehydrogenase family
F1734_24785	COG0583	DNA-binding transcription factor activity
F1734_24790	COG2267	carboxylic ester hydrolase activity
F1734_24795	COG3384	dioxygenase
F1734_24800	COG0657	acetylesterase activity
F1734_24810	COG4829	muconolactone delta-isomerase
F1734_24815	COG4948	Mandelate Racemase Muconate Lactonizing
F1734_24820	COG3485	protocatechuate 3,4-dioxygenase
F1734_24825	COG1414	Transcriptional regulator
F1734_24835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1734_24865	COG4638	Rieske (2fe-2S)
F1734_24885	COG2814	Major facilitator Superfamily
F1734_24900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1734_24960	COG0346	lactoylglutathione lyase activity
F1734_24970	COG5650	phosphatidylinositol metabolic process
F1734_24980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F1734_24990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F1734_24995	COG2072	flavoprotein involved in K transport
F1734_25020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F1734_25035	COG2186	Transcriptional regulator
F1734_25040	COG1024	Enoyl-CoA hydratase
F1734_25045	COG2186	Transcriptional regulator
F1734_25060	COG1028	Short-chain dehydrogenase reductase Sdr
F1734_25065	COG2072	flavoprotein involved in K transport
F1734_25085	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1734_25085	COG1902	pentaerythritol trinitrate reductase activity
F1734_25110	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_25120	COG5479	isomerase activity
F1734_25120	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1734_25180	COG1309	transcriptional regulator
F1734_25190	COG0183	Belongs to the thiolase family
F1734_25195	COG0318	PFAM AMP-dependent synthetase and ligase
F1734_25200	COG1024	Enoyl-CoA hydratase
F1734_25205	COG1960	acyl-CoA dehydrogenase activity
F1734_25215	COG2030	dehydratase
F1734_25215	COG1012	belongs to the aldehyde dehydrogenase family
F1734_25220	COG0183	Belongs to the thiolase family
F1734_25250	COG0785	Cytochrome C biogenesis protein
F1734_25255	COG1333	cytochrome c biogenesis protein
F1734_25260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F1734_25325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F1734_25340	COG0739	heme binding
F1734_25345	COG3336	cytochrome c oxidase
F1734_25365	COG2132	Multicopper oxidase
F1734_25390	COG0640	Transcriptional regulator
F1734_25535	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
F1734_25635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1734_25660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F1734_25675	COG0477	Major facilitator Superfamily
F1734_25775	COG0477	Major facilitator Superfamily
F1734_25780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1734_25795	COG2409	Drug exporters of the RND superfamily
F1734_25800	COG4644	lycopene metabolic process
F1734_25805	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1734_25805	COG5479	isomerase activity
F1734_25825	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F1734_25825	COG5479	isomerase activity
F1734_25920	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
F1734_25925	COG1396	sequence-specific DNA binding