locus-tag	class	description
HTY51_00005	COG1338	Plays a role in the flagellum-specific transport system
HTY51_00035	COG0745	RESPONSE REGULATOR receiver
HTY51_00040	COG0643	Histidine kinase
HTY51_00040	COG2198	Histidine kinase
HTY51_00045	COG0835	chemotaxis
HTY51_00050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HTY51_00055	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HTY51_00060	COG2201	protein-glutamate methylesterase activity
HTY51_00125	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_00135	COG4535	Mg2 and Co2 transporter CorC
HTY51_00140	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HTY51_00145	COG0752	glycyl-tRNA synthetase alpha subunit
HTY51_00150	COG0751	glycine-tRNA ligase activity
HTY51_00155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HTY51_00175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HTY51_00190	COG0789	Transcriptional regulator
HTY51_00195	COG1960	acyl-CoA dehydrogenase activity
HTY51_00200	COG0288	reversible hydration of carbon dioxide
HTY51_00205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HTY51_00210	COG0183	Belongs to the thiolase family
HTY51_00220	COG1960	acyl-CoA dehydrogenase activity
HTY51_00235	COG3012	SEC-C Motif Domain Protein
HTY51_00240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HTY51_00250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HTY51_00260	COG0156	8-amino-7-oxononanoate synthase activity
HTY51_00265	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HTY51_00275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HTY51_00295	COG0683	leucine binding
HTY51_00300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HTY51_00325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HTY51_00335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HTY51_00340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HTY51_00355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HTY51_00365	COG0515	serine threonine protein kinase
HTY51_00365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HTY51_00370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HTY51_00375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HTY51_00390	COG0316	Belongs to the HesB IscA family
HTY51_00395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HTY51_00400	COG0739	heme binding
HTY51_00405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HTY51_00420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HTY51_00425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY51_00430	COG3217	Mosc domain protein beta barrel domain protein
HTY51_00430	COG0633	Ferredoxin
HTY51_00435	COG0583	DNA-binding transcription factor activity
HTY51_00440	COG2828	Protein conserved in bacteria
HTY51_00445	COG0012	GTP binding
HTY51_00475	COG1238	metal cluster binding
HTY51_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HTY51_00490	COG0138	bifunctional purine biosynthesis protein purh
HTY51_00495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HTY51_00505	COG1773	rubredoxin
HTY51_00520	COG0835	chemotaxis
HTY51_00525	COG0840	transmembrane signaling receptor activity
HTY51_00530	COG0643	Histidine kinase
HTY51_00530	COG2198	Histidine kinase
HTY51_00530	COG0784	Response regulator, receiver
HTY51_00535	COG0415	Belongs to the DNA photolyase family
HTY51_00540	COG1678	Uncharacterized ACR, COG1678
HTY51_00545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HTY51_00550	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HTY51_00555	COG0540	Belongs to the ATCase OTCase family
HTY51_00570	COG3842	ATPase activity
HTY51_00575	COG1178	ABC-type Fe3 transport system permease component
HTY51_00590	COG0446	pyridine nucleotide-disulphide oxidoreductase
HTY51_00600	COG2391	methyltransferase activity
HTY51_00615	COG0840	transmembrane signaling receptor activity
HTY51_00640	COG2897	thiosulfate sulfurtransferase activity
HTY51_00645	COG1490	D-aminoacyl-tRNA deacylase activity
HTY51_00655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HTY51_00660	COG1702	phosphate starvation-inducible protein PhoH
HTY51_00665	COG0632	four-way junction helicase activity
HTY51_00670	COG3338	carbonate dehydratase activity
HTY51_00675	COG2255	four-way junction helicase activity
HTY51_00700	COG4566	intracellular signal transduction
HTY51_00725	COG0037	tRNA processing
HTY51_00735	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_00760	COG0617	tRNA 3'-terminal CCA addition
HTY51_00775	COG1196	nuclear chromosome segregation
HTY51_00775	COG0741	lytic transglycosylase activity
HTY51_00775	COG0739	heme binding
HTY51_00780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HTY51_00800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HTY51_00805	COG4251	negative regulation of phosphorylation
HTY51_00845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HTY51_00885	COG5002	protein histidine kinase activity
HTY51_00910	COG2129	metallophosphoesterase
HTY51_00920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTY51_00940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HTY51_00995	COG2814	Major facilitator Superfamily
HTY51_01015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY51_01030	COG0642	Histidine kinase
HTY51_01055	COG1136	(ABC) transporter
HTY51_01065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTY51_01075	COG3038	cytochrome b561
HTY51_01080	COG0745	RESPONSE REGULATOR receiver
HTY51_01085	COG2205	protein histidine kinase activity
HTY51_01110	COG1595	DNA-templated transcription, initiation
HTY51_01120	COG0753	catalase activity
HTY51_01170	COG2010	Cytochrome c
HTY51_01170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HTY51_01175	COG2080	2 iron, 2 sulfur cluster binding
HTY51_01200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HTY51_01205	COG4178	(ABC) transporter
HTY51_01220	COG0121	glutamine amidotransferase
HTY51_01230	COG0583	DNA-binding transcription factor activity
HTY51_01235	COG0583	DNA-binding transcription factor activity
HTY51_01240	COG1850	ribulose-bisphosphate carboxylase activity
HTY51_01245	COG4451	ribulose bisphosphate carboxylase, small
HTY51_01250	COG0464	growth
HTY51_01255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HTY51_01260	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HTY51_01265	COG3954	Phosphoribulokinase
HTY51_01270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HTY51_01275	COG0546	phosphoglycolate phosphatase activity
HTY51_01280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HTY51_01285	COG0126	phosphoglycerate kinase activity
HTY51_01290	COG0191	fructose-bisphosphate aldolase activity
HTY51_01300	COG1937	Protein conserved in bacteria
HTY51_01325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HTY51_01330	COG4654	Cytochrome c, class I
HTY51_01370	COG0840	transmembrane signaling receptor activity
HTY51_01410	COG1414	Transcriptional regulator
HTY51_01420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HTY51_01425	COG0183	Belongs to the thiolase family
HTY51_01430	COG2860	membrane
HTY51_01440	COG0402	S-adenosylhomocysteine deaminase activity
HTY51_01475	COG1575	Belongs to the MenA family. Type 1 subfamily
HTY51_01480	COG1846	Transcriptional regulator
HTY51_01485	COG1764	response to oxidative stress
HTY51_01530	COG3485	protocatechuate 3,4-dioxygenase
HTY51_01570	COG0778	Nitroreductase
HTY51_01585	COG3485	protocatechuate 3,4-dioxygenase
HTY51_01610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HTY51_01615	COG1040	competence protein
HTY51_01620	COG2226	methyltransferase
HTY51_01630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HTY51_01635	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HTY51_01665	COG1612	heme a metabolic process
HTY51_01670	COG0109	protoheme IX farnesyltransferase activity
HTY51_01675	COG1999	signal sequence binding
HTY51_01680	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_01685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTY51_01705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HTY51_01710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTY51_01715	COG2890	protein-(glutamine-N5) methyltransferase activity
HTY51_01720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HTY51_01725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HTY51_01745	COG0584	glycerophosphoryl diester phosphodiesterase
HTY51_01750	COG3842	ATPase activity
HTY51_01755	COG0395	ABC-type sugar transport system, permease component
HTY51_01760	COG1175	transmembrane transport
HTY51_01780	COG2226	methyltransferase
HTY51_01795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTY51_01815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HTY51_01820	COG0494	nUDIX hydrolase
HTY51_01830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY51_01835	COG0302	gtp cyclohydrolase
HTY51_01865	COG0793	Belongs to the peptidase S41A family
HTY51_01870	COG0588	phosphoglycerate mutase activity
HTY51_01875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTY51_01880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HTY51_01885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HTY51_01890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HTY51_01895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HTY51_01895	COG1181	Belongs to the D-alanine--D-alanine ligase family
HTY51_01900	COG0189	ligase activity
HTY51_01900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HTY51_01905	COG1132	(ABC) transporter
HTY51_01920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HTY51_01925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HTY51_01935	COG0406	alpha-ribazole phosphatase activity
HTY51_01940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HTY51_01950	COG0193	aminoacyl-tRNA hydrolase activity
HTY51_01955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HTY51_01960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HTY51_01970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HTY51_01985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HTY51_02000	COG1660	Displays ATPase and GTPase activities
HTY51_02005	COG0497	DNA recombination
HTY51_02010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HTY51_02015	COG1420	regulation of RNA biosynthetic process
HTY51_02030	COG2267	carboxylic ester hydrolase activity
HTY51_02050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HTY51_02055	COG1758	RNA polymerase activity
HTY51_02060	COG0194	GDP metabolic process
HTY51_02065	COG1561	YicC-like family, N-terminal region
HTY51_02085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HTY51_02090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTY51_02095	COG0517	IMP dehydrogenase activity
HTY51_02095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HTY51_02095	COG0617	tRNA 3'-terminal CCA addition
HTY51_02105	COG0582	viral genome integration into host DNA
HTY51_02165	COG1742	UPF0060 membrane protein
HTY51_02170	COG0789	Transcriptional regulator
HTY51_02185	COG0583	DNA-binding transcription factor activity
HTY51_02200	COG5377	YqaJ viral recombinase family
HTY51_02255	COG2084	Dehydrogenase
HTY51_02260	COG3622	Belongs to the hyi family
HTY51_02265	COG3960	tartronate-semialdehyde synthase activity
HTY51_02270	COG0583	DNA-binding transcription factor activity
HTY51_02315	COG0717	Belongs to the dCTP deaminase family
HTY51_02325	COG2423	ornithine cyclodeaminase activity
HTY51_02330	COG0513	Belongs to the DEAD box helicase family
HTY51_02335	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HTY51_02340	COG0515	serine threonine protein kinase
HTY51_02345	COG1253	flavin adenine dinucleotide binding
HTY51_02360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HTY51_02380	COG1704	LemA family
HTY51_02400	COG0859	PFAM glycosyl transferase family 9
HTY51_02430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTY51_02430	COG0425	Belongs to the sulfur carrier protein TusA family
HTY51_02435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HTY51_02450	COG1309	transcriptional regulator
HTY51_02455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTY51_02460	COG1136	(ABC) transporter
HTY51_02460	COG0577	efflux transmembrane transporter activity
HTY51_02485	COG0679	Auxin Efflux Carrier
HTY51_02490	COG0259	pyridoxamine-phosphate oxidase activity
HTY51_02505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HTY51_02505	COG3608	succinylglutamate desuccinylase aspartoacylase
HTY51_02520	COG0346	lactoylglutathione lyase activity
HTY51_02530	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_02535	COG0513	Belongs to the DEAD box helicase family
HTY51_02545	COG0488	(ABC) transporter
HTY51_02560	COG3191	aminopeptidase activity
HTY51_02565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HTY51_02620	COG3258	Cytochrome c
HTY51_02640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HTY51_02655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY51_02670	COG0589	response to stress
HTY51_02675	COG0840	transmembrane signaling receptor activity
HTY51_02685	COG4191	Histidine kinase
HTY51_02690	COG2205	protein histidine kinase activity
HTY51_02695	COG0745	RESPONSE REGULATOR receiver
HTY51_02700	COG3158	transport of potassium into the cell
HTY51_02715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HTY51_02720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HTY51_02725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HTY51_02730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HTY51_02735	COG1309	transcriptional regulator
HTY51_02790	COG5002	protein histidine kinase activity
HTY51_02830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HTY51_02835	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HTY51_02880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTY51_02890	COG2217	Heavy metal translocating P-type atpase
HTY51_02955	COG1525	nuclease
HTY51_03020	COG4575	ribosome binding
HTY51_03045	COG0517	IMP dehydrogenase activity
HTY51_03045	COG0516	GMP reductase activity
HTY51_03050	COG0840	transmembrane signaling receptor activity
HTY51_03055	COG0288	reversible hydration of carbon dioxide
HTY51_03060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HTY51_03065	COG2181	nitrate reductase activity
HTY51_03070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HTY51_03075	COG1140	nitrate reductase beta subunit
HTY51_03080	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HTY51_03100	COG0583	DNA-binding transcription factor activity
HTY51_03115	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HTY51_03130	COG2197	response regulator
HTY51_03135	COG3850	Histidine kinase
HTY51_03145	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_03150	COG0564	pseudouridine synthase activity
HTY51_03170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HTY51_03170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY51_03190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HTY51_03225	COG0583	DNA-binding transcription factor activity
HTY51_03240	COG0163	prenyltransferase activity
HTY51_03270	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_03275	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_03305	COG1024	Enoyl-CoA hydratase
HTY51_03335	COG2267	carboxylic ester hydrolase activity
HTY51_03345	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_03360	COG2918	glutathione biosynthetic process
HTY51_03370	COG1530	ribonuclease E activity
HTY51_03390	COG0616	signal peptide processing
HTY51_03390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HTY51_03400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HTY51_03405	COG0424	maF-like protein
HTY51_03410	COG1399	metal-binding, possibly nucleic acid-binding protein
HTY51_03415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HTY51_03420	COG0416	fatty acid biosynthetic process
HTY51_03425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HTY51_03430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HTY51_03435	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_03440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HTY51_03445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTY51_03470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTY51_03475	COG0481	GTPase activity
HTY51_03490	COG0571	ribonuclease III activity
HTY51_03495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HTY51_03500	COG1381	Involved in DNA repair and RecF pathway recombination
HTY51_03505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HTY51_03510	COG0736	holo-[acyl-carrier-protein] synthase activity
HTY51_03515	COG1472	Belongs to the glycosyl hydrolase 3 family
HTY51_03520	COG0840	transmembrane signaling receptor activity
HTY51_03525	COG2329	Antibiotic biosynthesis monooxygenase
HTY51_03530	COG1451	nucleotide metabolic process
HTY51_03550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HTY51_03555	COG0762	integral membrane protein
HTY51_03560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HTY51_03570	COG0133	tryptophan synthase activity
HTY51_03575	COG0135	phosphoribosylanthranilate isomerase activity
HTY51_03580	COG0101	tRNA pseudouridine synthase activity
HTY51_03595	COG0473	3-isopropylmalate dehydrogenase activity
HTY51_03600	COG0066	3-isopropylmalate dehydratase activity
HTY51_03605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HTY51_03615	COG0372	Belongs to the citrate synthase family
HTY51_03620	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HTY51_03625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HTY51_03630	COG1053	succinate dehydrogenase
HTY51_03635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HTY51_03645	COG2188	Transcriptional regulator
HTY51_03650	COG0039	L-malate dehydrogenase activity
HTY51_03670	COG1392	Phosphate transport regulator
HTY51_03675	COG0306	phosphate transporter
HTY51_03685	COG0228	four-way junction DNA binding
HTY51_03690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HTY51_03695	COG0336	Belongs to the RNA methyltransferase TrmD family
HTY51_03700	COG0335	large ribosomal subunit rRNA binding
HTY51_03705	COG0494	nUDIX hydrolase
HTY51_03715	COG1162	GTPase activity
HTY51_03720	COG2154	pterin-4-alpha-carbinolamine dehydratase
HTY51_03725	COG0501	Belongs to the peptidase M48B family
HTY51_03730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HTY51_03735	COG0513	Belongs to the DEAD box helicase family
HTY51_03750	COG2233	PERMEase
HTY51_03755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY51_03770	COG2186	Transcriptional regulator
HTY51_03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY51_03795	COG1116	anion transmembrane transporter activity
HTY51_03800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTY51_03815	COG0583	DNA-binding transcription factor activity
HTY51_03820	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HTY51_03825	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_03845	COG0523	cobalamin synthesis protein
HTY51_03880	COG1459	type II secretion system
HTY51_03955	COG4214	carbohydrate transport
HTY51_03975	COG2084	Dehydrogenase
HTY51_03990	COG5002	protein histidine kinase activity
HTY51_03995	COG0210	DNA helicase
HTY51_04010	COG0217	transcriptional regulatory protein
HTY51_04020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HTY51_04035	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_04050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HTY51_04060	COG0513	Belongs to the DEAD box helicase family
HTY51_04065	COG0412	Dienelactone hydrolase
HTY51_04105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HTY51_04115	COG1722	exodeoxyribonuclease VII activity
HTY51_04120	COG0142	geranyltranstransferase activity
HTY51_04125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HTY51_04130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HTY51_04135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HTY51_04140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HTY51_04150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HTY51_04165	COG1122	ATPase activity
HTY51_04210	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTY51_04215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY51_04255	COG0437	4 iron, 4 sulfur cluster binding
HTY51_04260	COG2864	formate dehydrogenase
HTY51_04270	COG1921	L-seryl-tRNASec selenium transferase activity
HTY51_04275	COG3276	selenocysteine insertion sequence binding
HTY51_04285	COG0509	glycine decarboxylation via glycine cleavage system
HTY51_04305	COG0583	DNA-binding transcription factor activity
HTY51_04320	COG4335	DNA alkylation repair
HTY51_04325	COG4251	negative regulation of phosphorylation
HTY51_04325	COG3706	GGDEF domain
HTY51_04325	COG2203	Gaf domain
HTY51_04325	COG5001	Diguanylate cyclase
HTY51_04340	COG0443	Heat shock 70 kDa protein
HTY51_04345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HTY51_04400	COG3383	formate dehydrogenase (NAD+) activity
HTY51_04405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HTY51_04415	COG0625	glutathione transferase activity
HTY51_04430	COG2814	Major facilitator Superfamily
HTY51_04445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HTY51_04450	COG2414	aldehyde ferredoxin oxidoreductase
HTY51_04485	COG2210	Belongs to the sulfur carrier protein TusA family
HTY51_04490	COG0425	Belongs to the sulfur carrier protein TusA family
HTY51_04515	COG3302	dmso reductase anchor subunit
HTY51_04520	COG0437	4 iron, 4 sulfur cluster binding
HTY51_04525	COG0243	molybdopterin cofactor binding
HTY51_04530	COG3850	Histidine kinase
HTY51_04535	COG2197	response regulator
HTY51_04545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HTY51_04545	COG1648	precorrin-2 dehydrogenase activity
HTY51_04560	COG1797	cobyrinic acid a,c-diamide synthase activity
HTY51_04595	COG2920	part of a sulfur-relay system
HTY51_04600	COG2168	tRNA wobble position uridine thiolation
HTY51_04605	COG2923	Belongs to the DsrF TusC family
HTY51_04610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HTY51_04615	COG2221	Nitrite and sulphite reductase 4Fe-4S
HTY51_04620	COG2221	Nitrite and sulphite reductase 4Fe-4S
HTY51_04635	COG2920	part of a sulfur-relay system
HTY51_04675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HTY51_04720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTY51_04725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HTY51_04730	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HTY51_04740	COG0776	regulation of translation
HTY51_04750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HTY51_04755	COG0287	Prephenate dehydrogenase
HTY51_04760	COG1605	Chorismate mutase
HTY51_04760	COG0077	Prephenate dehydratase
HTY51_04765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HTY51_04780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTY51_04795	COG1187	pseudouridine synthase activity
HTY51_04825	COG0174	glutamine synthetase
HTY51_04865	COG0697	spore germination
HTY51_04870	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HTY51_04885	COG1024	Enoyl-CoA hydratase
HTY51_04890	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_04890	COG3321	synthase
HTY51_04890	COG0604	alcohol dehydrogenase
HTY51_04895	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_04900	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_04915	COG0277	FAD linked oxidase domain protein
HTY51_04925	COG1295	ribonuclease BN
HTY51_04935	COG2318	DinB family
HTY51_04965	COG2267	carboxylic ester hydrolase activity
HTY51_04975	COG1125	glycine betaine transport
HTY51_04975	COG0517	IMP dehydrogenase activity
HTY51_04995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HTY51_05000	COG0235	Class ii aldolase
HTY51_05005	COG1942	4-Oxalocrotonate Tautomerase
HTY51_05015	COG0778	Nitroreductase
HTY51_05020	COG0154	amidase activity
HTY51_05025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HTY51_05045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HTY51_05055	COG1305	Transglutaminase-like
HTY51_05060	COG2308	Evidence 4 Homologs of previously reported genes of
HTY51_05070	COG2308	Evidence 4 Homologs of previously reported genes of
HTY51_05100	COG0724	RNA recognition motif
HTY51_05105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HTY51_05115	COG5001	Diguanylate cyclase
HTY51_05115	COG2203	Gaf domain
HTY51_05115	COG3706	GGDEF domain
HTY51_05115	COG4251	negative regulation of phosphorylation
HTY51_05130	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HTY51_05135	COG0114	fumarate hydratase activity
HTY51_05155	COG2199	diguanylate cyclase activity
HTY51_05155	COG2200	EAL domain
HTY51_05170	COG3485	protocatechuate 3,4-dioxygenase
HTY51_05180	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_05185	COG0583	DNA-binding transcription factor activity
HTY51_05195	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_05200	COG1067	ATP-dependent peptidase activity
HTY51_05235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HTY51_05270	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_05275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HTY51_05285	COG1177	transmembrane transport
HTY51_05290	COG1176	ABC-type spermidine putrescine transport system, permease component I
HTY51_05295	COG3842	ATPase activity
HTY51_05300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HTY51_05305	COG0583	DNA-binding transcription factor activity
HTY51_05310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HTY51_05315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY51_05330	COG1305	Transglutaminase-like
HTY51_05335	COG0683	leucine binding
HTY51_05345	COG0683	leucine binding
HTY51_05350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HTY51_05355	COG1024	Enoyl-CoA hydratase
HTY51_05370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HTY51_05375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HTY51_05385	COG0277	FAD linked oxidase domain protein
HTY51_05385	COG0247	lactate metabolic process
HTY51_05410	COG0204	Acyl-transferase
HTY51_05420	COG0589	response to stress
HTY51_05430	COG1309	transcriptional regulator
HTY51_05435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HTY51_05450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTY51_05450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY51_05455	COG2391	methyltransferase activity
HTY51_05490	COG5002	protein histidine kinase activity
HTY51_05500	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HTY51_05540	COG0564	pseudouridine synthase activity
HTY51_05545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HTY51_05550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HTY51_05555	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HTY51_05560	COG0583	DNA-binding transcription factor activity
HTY51_05565	COG1741	Belongs to the pirin family
HTY51_05580	COG1741	Belongs to the pirin family
HTY51_05585	COG0840	transmembrane signaling receptor activity
HTY51_05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HTY51_05625	COG0405	Gamma-glutamyltransferase
HTY51_05640	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HTY51_05645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HTY51_05650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTY51_05660	COG0557	exoribonuclease II activity
HTY51_05670	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY51_05670	COG0596	Alpha beta hydrolase
HTY51_05680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HTY51_05680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HTY51_05690	COG1418	mRNA catabolic process
HTY51_05695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTY51_05705	COG0052	Belongs to the universal ribosomal protein uS2 family
HTY51_05710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HTY51_05715	COG0528	UMP kinase activity
HTY51_05720	COG0233	cytoplasmic translational termination
HTY51_05735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HTY51_05740	COG0750	zinc metalloprotease
HTY51_05755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTY51_05760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HTY51_05765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTY51_05770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTY51_05775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HTY51_05780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTY51_05785	COG0505	Belongs to the CarA family
HTY51_05790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HTY51_05795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HTY51_05805	COG1534	Rna-binding protein
HTY51_05810	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HTY51_05815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTY51_05825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HTY51_05830	COG1393	Belongs to the ArsC family
HTY51_05835	COG0798	PFAM Bile acid sodium symporter
HTY51_05870	COG0297	glycogen (starch) synthase activity
HTY51_05890	COG3300	MHYT domain
HTY51_05890	COG5001	Diguanylate cyclase
HTY51_05920	COG0688	phosphatidylethanolamine metabolic process
HTY51_05940	COG0248	Ppx GppA phosphatase
HTY51_05950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HTY51_05955	COG0573	inorganic phosphate transmembrane transporter activity
HTY51_05960	COG0581	inorganic phosphate transmembrane transporter activity
HTY51_05965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HTY51_05975	COG0745	RESPONSE REGULATOR receiver
HTY51_05990	COG0534	Mate efflux family protein
HTY51_06000	COG0254	rRNA binding
HTY51_06005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HTY51_06020	COG1074	ATP-dependent DNA helicase activity
HTY51_06025	COG2081	HI0933 family
HTY51_06045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HTY51_06050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HTY51_06060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTY51_06080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY51_06085	COG0741	lytic transglycosylase activity
HTY51_06085	COG1388	LysM domain
HTY51_06090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY51_06100	COG0328	RNA-DNA hybrid ribonuclease activity
HTY51_06105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTY51_06110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTY51_06115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HTY51_06120	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HTY51_06130	COG0746	molybdenum cofactor guanylyltransferase activity
HTY51_06135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HTY51_06170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HTY51_06175	COG0835	chemotaxis
HTY51_06195	COG0347	Belongs to the P(II) protein family
HTY51_06205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HTY51_06225	COG1595	DNA-templated transcription, initiation
HTY51_06230	COG0028	Belongs to the TPP enzyme family
HTY51_06235	COG0440	acetolactate synthase activity
HTY51_06240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HTY51_06245	COG1183	phosphatidylcholine synthase activity
HTY51_06250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HTY51_06260	COG1414	Transcriptional regulator
HTY51_06265	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HTY51_06270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HTY51_06285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HTY51_06300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTY51_06305	COG4654	Cytochrome c, class I
HTY51_06315	COG0129	dihydroxy-acid dehydratase activity
HTY51_06320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HTY51_06325	COG1802	Transcriptional regulator
HTY51_06340	COG1024	Enoyl-CoA hydratase
HTY51_06345	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_06355	COG0589	response to stress
HTY51_06360	COG2217	Heavy metal translocating P-type atpase
HTY51_06370	COG3278	Belongs to the heme-copper respiratory oxidase family
HTY51_06405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY51_06410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HTY51_06420	COG1215	transferase activity, transferring glycosyl groups
HTY51_06430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTY51_06435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HTY51_06450	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_06465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HTY51_06485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HTY51_06490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTY51_06510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HTY51_06520	COG1802	Transcriptional regulator
HTY51_06525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HTY51_06525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HTY51_06535	COG1703	isobutyryl-CoA mutase activity
HTY51_06540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HTY51_06550	COG4770	biotin carboxylase activity
HTY51_06560	COG0840	transmembrane signaling receptor activity
HTY51_06565	COG2878	Part of a membrane complex involved in electron transport
HTY51_06575	COG3384	dioxygenase
HTY51_06590	COG0513	Belongs to the DEAD box helicase family
HTY51_06600	COG1752	Esterase of the alpha-beta hydrolase superfamily
HTY51_06625	COG0556	nucleotide-excision repair
HTY51_06630	COG1959	2 iron, 2 sulfur cluster binding
HTY51_06635	COG1104	cysteine desulfurase activity
HTY51_06640	COG0822	iron-sulfur transferase activity
HTY51_06650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HTY51_06655	COG0443	Heat shock 70 kDa protein
HTY51_06705	COG0579	oxidoreductase
HTY51_06710	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_06730	COG0583	DNA-binding transcription factor activity
HTY51_06735	COG0167	dihydroorotate dehydrogenase activity
HTY51_06740	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HTY51_06755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HTY51_06760	COG4566	intracellular signal transduction
HTY51_06765	COG4191	Histidine kinase
HTY51_06775	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY51_06780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTY51_06810	COG0791	NLP P60 protein
HTY51_06815	COG0604	alcohol dehydrogenase
HTY51_06835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HTY51_06865	COG2329	Antibiotic biosynthesis monooxygenase
HTY51_06890	COG3243	poly(R)-hydroxyalkanoic acid synthase
HTY51_06895	COG0183	Belongs to the thiolase family
HTY51_06900	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_06910	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HTY51_06910	COG3608	succinylglutamate desuccinylase aspartoacylase
HTY51_06925	COG2207	Transcriptional regulator
HTY51_06930	COG2814	Major facilitator Superfamily
HTY51_06940	COG1272	protein, Hemolysin III
HTY51_06955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HTY51_06960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HTY51_06965	COG0022	dehydrogenase e1 component
HTY51_06995	COG1136	(ABC) transporter
HTY51_07000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HTY51_07000	COG2199	diguanylate cyclase activity
HTY51_07005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HTY51_07045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HTY51_07050	COG0730	response to heat
HTY51_07075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HTY51_07080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HTY51_07085	COG1120	ATPase activity
HTY51_07090	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HTY51_07095	COG1492	cobalamin metabolic process
HTY51_07105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HTY51_07120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY51_07150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HTY51_07155	COG1174	glycine betaine transport
HTY51_07165	COG1902	pentaerythritol trinitrate reductase activity
HTY51_07165	COG0446	pyridine nucleotide-disulphide oxidoreductase
HTY51_07205	COG0023	Translation Initiation Factor
HTY51_07235	COG2059	Chromate
HTY51_07245	COG5001	Diguanylate cyclase
HTY51_07245	COG5002	protein histidine kinase activity
HTY51_07260	COG5002	protein histidine kinase activity
HTY51_07260	COG5001	Diguanylate cyclase
HTY51_07270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HTY51_07275	COG3437	response regulator, receiver
HTY51_07275	COG0784	Response regulator, receiver
HTY51_07280	COG5002	protein histidine kinase activity
HTY51_07285	COG0784	Response regulator, receiver
HTY51_07285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY51_07285	COG2198	Histidine kinase
HTY51_07285	COG2205	protein histidine kinase activity
HTY51_07290	COG5002	protein histidine kinase activity
HTY51_07300	COG5002	protein histidine kinase activity
HTY51_07310	COG0745	RESPONSE REGULATOR receiver
HTY51_07320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY51_07325	COG1414	Transcriptional regulator
HTY51_07340	COG0826	peptidase U32
HTY51_07345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HTY51_07350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HTY51_07360	COG2917	probably involved in intracellular septation
HTY51_07365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HTY51_07370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HTY51_07375	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_07395	COG0411	ABC transporter
HTY51_07405	COG1024	Enoyl-CoA hydratase
HTY51_07405	COG1250	3-hydroxyacyl-CoA dehydrogenase
HTY51_07410	COG0183	Belongs to the thiolase family
HTY51_07415	COG1960	acyl-CoA dehydrogenase activity
HTY51_07425	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_07435	COG2130	NADP-dependent
HTY51_07450	COG5001	Diguanylate cyclase
HTY51_07450	COG5002	protein histidine kinase activity
HTY51_07460	COG2183	response to ionizing radiation
HTY51_07500	COG0354	folic acid binding
HTY51_07505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HTY51_07510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HTY51_07515	COG0470	DNA polymerase III
HTY51_07525	COG0084	hydrolase, TatD family'
HTY51_07560	COG1619	proteins homologs of microcin C7 resistance protein MccF
HTY51_07585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HTY51_07585	COG0519	Catalyzes the synthesis of GMP from XMP
HTY51_07600	COG2914	Belongs to the UPF0125 (RnfH) family
HTY51_07605	COG2867	negative regulation of translational initiation
HTY51_07610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HTY51_07620	COG1024	Enoyl-CoA hydratase
HTY51_07635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HTY51_07640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HTY51_07645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HTY51_07650	COG0195	Participates in both transcription termination and antitermination
HTY51_07650	COG2251	uridine kinase activity
HTY51_07655	COG0779	Required for maturation of 30S ribosomal subunits
HTY51_07660	COG4172	Belongs to the ABC transporter superfamily
HTY51_07665	COG4239	(ABC) transporter, permease
HTY51_07670	COG4174	ABC transporter (Permease)
HTY51_07675	COG4166	transmembrane transport
HTY51_07685	COG1982	Orn Lys Arg decarboxylase major
HTY51_07700	COG1607	acyl-coa hydrolase
HTY51_07705	COG1525	nuclease
HTY51_07730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HTY51_07735	COG0795	lipopolysaccharide-transporting ATPase activity
HTY51_07750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTY51_07800	COG0583	DNA-binding transcription factor activity
HTY51_07805	COG0436	Aminotransferase
HTY51_07870	COG1309	transcriptional regulator
HTY51_07885	COG1136	(ABC) transporter
HTY51_07890	COG1643	Atp-dependent helicase
HTY51_07895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HTY51_07895	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HTY51_07970	COG1222	aaa ATPase
HTY51_08000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY51_08000	COG4191	Histidine kinase
HTY51_08020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HTY51_08025	COG0840	transmembrane signaling receptor activity
HTY51_08030	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HTY51_08035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HTY51_08040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HTY51_08040	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HTY51_08045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTY51_08055	COG0730	response to heat
HTY51_08070	COG0175	sulfate reduction
HTY51_08075	COG0175	sulfate reduction
HTY51_08085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HTY51_08090	COG0492	ferredoxin-NADP+ reductase activity
HTY51_08095	COG0351	phosphomethylpyrimidine kinase
HTY51_08105	COG2104	thiamine diphosphate biosynthetic process
HTY51_08110	COG2022	thiamine diphosphate biosynthetic process
HTY51_08155	COG3706	GGDEF domain
HTY51_08160	COG0047	phosphoribosylformylglycinamidine synthase activity
HTY51_08160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HTY51_08165	COG0024	Methionine aminopeptidase
HTY51_08175	COG0242	peptide deformylase activity
HTY51_08180	COG2832	Protein of unknown function (DUF454)
HTY51_08185	COG0840	transmembrane signaling receptor activity
HTY51_08200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HTY51_08210	COG1196	nuclear chromosome segregation
HTY51_08230	COG2171	N-acyltransferase activity
HTY51_08240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HTY51_08245	COG2890	protein-(glutamine-N5) methyltransferase activity
HTY51_08250	COG0488	(ABC) transporter
HTY51_08280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HTY51_08285	COG2391	methyltransferase activity
HTY51_08295	COG2885	chlorophyll binding
HTY51_08300	COG0823	Involved in the tonB-independent uptake of proteins
HTY51_08320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTY51_08350	COG0438	transferase activity, transferring glycosyl groups
HTY51_08355	COG1530	ribonuclease E activity
HTY51_08360	COG0424	maF-like protein
HTY51_08365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HTY51_08370	COG0799	negative regulation of ribosome biogenesis
HTY51_08375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HTY51_08380	COG0408	coproporphyrinogen oxidase activity
HTY51_08390	COG0151	Belongs to the GarS family
HTY51_08395	COG0217	transcriptional regulatory protein
HTY51_08400	COG0433	COG0433 Predicted ATPase
HTY51_08410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HTY51_08420	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_08425	COG0515	serine threonine protein kinase
HTY51_08425	COG2815	serine threonine protein kinase
HTY51_08435	COG0745	RESPONSE REGULATOR receiver
HTY51_08445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HTY51_08445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HTY51_08450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HTY51_08450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HTY51_08455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HTY51_08465	COG0560	Phosphoserine phosphatase
HTY51_08470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY51_08480	COG3540	Alkaline phosphatase
HTY51_08495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HTY51_08505	COG4181	ATPase activity
HTY51_08515	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HTY51_08530	COG3739	integral membrane protein
HTY51_08545	COG0842	Transport permease protein
HTY51_08550	COG1131	(ABC) transporter
HTY51_08560	COG0626	cystathionine gamma-synthase activity
HTY51_08565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HTY51_08570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HTY51_08575	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HTY51_08580	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HTY51_08585	COG0330	HflC and HflK could
HTY51_08590	COG0330	HflC and HflK could
HTY51_08595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HTY51_08600	COG1923	regulation of RNA biosynthetic process
HTY51_08605	COG1160	GTP binding
HTY51_08620	COG0124	histidyl-tRNA synthetase
HTY51_08625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HTY51_08640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HTY51_08645	COG0105	UTP biosynthetic process
HTY51_08650	COG1187	pseudouridine synthase activity
HTY51_08655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HTY51_08670	COG1199	ATP-dependent helicase activity
HTY51_08690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HTY51_08695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HTY51_08700	COG2076	Multidrug Resistance protein
HTY51_08705	COG0508	dehydrogenase complex catalyzes the overall conversion of
HTY51_08710	COG0567	Dehydrogenase, E1 component
HTY51_08715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTY51_08800	COG0776	regulation of translation
HTY51_08805	COG0072	phenylalanine-tRNA ligase activity
HTY51_08805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY51_08810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HTY51_08815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HTY51_08820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HTY51_08825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HTY51_08830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HTY51_08855	COG0028	Belongs to the TPP enzyme family
HTY51_08880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HTY51_08915	COG5000	phosphorelay sensor kinase activity
HTY51_08915	COG3279	Response regulator of the LytR AlgR family
HTY51_08925	COG2194	sulfuric ester hydrolase activity
HTY51_08935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HTY51_08945	COG0625	glutathione transferase activity
HTY51_08950	COG0251	oxidation-reduction process
HTY51_08955	COG3386	PFAM SMP-30 Gluconolaconase
HTY51_08960	COG0123	including yeast histone deacetylase and acetoin utilization protein
HTY51_08965	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HTY51_08970	COG3657	addiction module killer protein
HTY51_08995	COG0745	RESPONSE REGULATOR receiver
HTY51_09005	COG1858	cytochrome C peroxidase
HTY51_09020	COG0542	response to heat
HTY51_09040	COG0583	DNA-binding transcription factor activity
HTY51_09045	COG0314	molybdopterin synthase activity
HTY51_09050	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HTY51_09055	COG0303	'Molybdopterin
HTY51_09060	COG1763	Mo-molybdopterin cofactor biosynthetic process
HTY51_09075	COG0436	Aminotransferase
HTY51_09085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTY51_09090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HTY51_09095	COG0305	Participates in initiation and elongation during chromosome replication
HTY51_09100	COG0359	binds to the 23S rRNA
HTY51_09105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HTY51_09110	COG2965	DNA replication, synthesis of RNA primer
HTY51_09115	COG0360	Binds together with S18 to 16S ribosomal RNA
HTY51_09120	COG2176	DNA-directed DNA polymerase activity
HTY51_09125	COG0517	IMP dehydrogenase activity
HTY51_09130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HTY51_09155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HTY51_09165	COG3128	pkhd-type hydroxylase
HTY51_09195	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HTY51_09200	COG0670	Belongs to the BI1 family
HTY51_09210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HTY51_09220	COG0745	RESPONSE REGULATOR receiver
HTY51_09225	COG0840	transmembrane signaling receptor activity
HTY51_09235	COG3300	MHYT domain
HTY51_09235	COG5001	Diguanylate cyclase
HTY51_09250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HTY51_09265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HTY51_09270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HTY51_09285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HTY51_09300	COG0697	spore germination
HTY51_09310	COG0322	excinuclease ABC activity
HTY51_09315	COG2925	Exonuclease
HTY51_09325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HTY51_09330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HTY51_09335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HTY51_09340	COG1611	Belongs to the LOG family
HTY51_09355	COG1846	Transcriptional regulator
HTY51_09365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HTY51_09370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HTY51_09395	COG1752	Esterase of the alpha-beta hydrolase superfamily
HTY51_09400	COG1840	ABC-type Fe3 transport system, periplasmic component
HTY51_09405	COG0542	response to heat
HTY51_09410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HTY51_09425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HTY51_09430	COG1570	exodeoxyribonuclease VII activity
HTY51_09435	COG0811	peptide transport
HTY51_09440	COG0848	biopolymer transport protein
HTY51_09445	COG1663	tetraacyldisaccharide 4'-kinase activity
HTY51_09450	COG2835	tetraacyldisaccharide 4'-kinase activity
HTY51_09455	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HTY51_09460	COG0563	adenylate kinase activity
HTY51_09480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HTY51_09490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HTY51_09495	COG0625	glutathione transferase activity
HTY51_09500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HTY51_09505	COG1024	Enoyl-CoA hydratase
HTY51_09510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY51_09525	COG0625	glutathione transferase activity
HTY51_09540	COG3409	Peptidoglycan-binding domain 1 protein
HTY51_09540	COG3267	Type II secretory pathway component ExeA
HTY51_09570	COG4968	Prepilin-type N-terminal cleavage methylation domain
HTY51_09580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HTY51_09610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTY51_09615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HTY51_09620	COG0740	serine-type endopeptidase activity
HTY51_09625	COG0544	peptidyl-prolyl cis-trans isomerase activity
HTY51_09635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTY51_09640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTY51_09650	COG1562	ergosterol biosynthetic process
HTY51_09655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HTY51_09665	COG1011	Hydrolase
HTY51_09670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HTY51_09675	COG0625	glutathione transferase activity
HTY51_09705	COG0411	ABC transporter
HTY51_09730	COG0527	aspartate kinase activity
HTY51_09735	COG0037	tRNA processing
HTY51_09740	COG0825	malonyl-CoA metabolic process
HTY51_09750	COG0215	cysteine-tRNA ligase activity
HTY51_09780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HTY51_09785	COG3228	Belongs to the MtfA family
HTY51_09795	COG0741	lytic transglycosylase activity
HTY51_09800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HTY51_09805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HTY51_09810	COG4968	Prepilin-type N-terminal cleavage methylation domain
HTY51_09840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTY51_09840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HTY51_09860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HTY51_09865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HTY51_09870	COG0436	Aminotransferase
HTY51_09875	COG0824	Thioesterase
HTY51_09905	COG0583	DNA-binding transcription factor activity
HTY51_09920	COG0745	RESPONSE REGULATOR receiver
HTY51_09935	COG3706	GGDEF domain
HTY51_09940	COG1002	Type II restriction enzyme, methylase subunits
HTY51_09950	COG0667	Aldo Keto reductase
HTY51_09985	COG2159	amidohydrolase
HTY51_10005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HTY51_10045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HTY51_10060	COG1024	Enoyl-CoA hydratase
HTY51_10065	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_10080	COG0559	Belongs to the binding-protein-dependent transport system permease family
HTY51_10100	COG1960	acyl-CoA dehydrogenase activity
HTY51_10120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HTY51_10125	COG0443	Heat shock 70 kDa protein
HTY51_10130	COG0484	heat shock protein binding
HTY51_10135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HTY51_10145	COG3706	GGDEF domain
HTY51_10155	COG1960	acyl-CoA dehydrogenase activity
HTY51_10170	COG1511	domain protein
HTY51_10170	COG3264	Mechanosensitive ion channel
HTY51_10180	COG0123	including yeast histone deacetylase and acetoin utilization protein
HTY51_10185	COG0714	Associated with various cellular activities
HTY51_10205	COG2951	lytic endotransglycosylase activity
HTY51_10220	COG0840	transmembrane signaling receptor activity
HTY51_10225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HTY51_10230	COG0617	tRNA 3'-terminal CCA addition
HTY51_10240	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HTY51_10245	COG0628	permease
HTY51_10250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HTY51_10260	COG1192	Involved in chromosome partitioning
HTY51_10270	COG0728	peptidoglycan biosynthetic process
HTY51_10275	COG0268	Binds directly to 16S ribosomal RNA
HTY51_10285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HTY51_10290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HTY51_10300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY51_10310	COG1196	nuclear chromosome segregation
HTY51_10310	COG0741	lytic transglycosylase activity
HTY51_10310	COG0739	heme binding
HTY51_10335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HTY51_10340	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HTY51_10350	COG2850	peptidyl-arginine hydroxylation
HTY51_10355	COG1047	Peptidyl-prolyl cis-trans
HTY51_10360	COG0756	dUTP diphosphatase activity
HTY51_10365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HTY51_10370	COG0504	CTP synthase activity
HTY51_10375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HTY51_10385	COG0148	phosphopyruvate hydratase activity
HTY51_10390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HTY51_10400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HTY51_10410	COG2833	Protein of unknown function (DUF455)
HTY51_10415	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HTY51_10420	COG0625	glutathione transferase activity
HTY51_10425	COG4974	Belongs to the 'phage' integrase family
HTY51_10430	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_10450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HTY51_10455	COG0802	atpase or kinase
HTY51_10460	COG0860	N-Acetylmuramoyl-L-alanine amidase
HTY51_10475	COG0586	Pfam SNARE associated Golgi protein
HTY51_10480	COG2354	Protein conserved in bacteria
HTY51_10485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HTY51_10490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HTY51_10490	COG0425	Belongs to the sulfur carrier protein TusA family
HTY51_10495	COG0537	adenosine 5'-monophosphoramidase activity
HTY51_10505	COG2814	Major facilitator Superfamily
HTY51_10510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HTY51_10525	COG0071	Belongs to the small heat shock protein (HSP20) family
HTY51_10540	COG2169	Transcriptional regulator
HTY51_10540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HTY51_10550	COG0784	Response regulator, receiver
HTY51_10550	COG0835	chemotaxis
HTY51_10555	COG1132	(ABC) transporter
HTY51_10580	COG1007	ATP synthesis coupled electron transport
HTY51_10595	COG0713	ATP synthesis coupled electron transport
HTY51_10605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTY51_10610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HTY51_10615	COG1034	ATP synthesis coupled electron transport
HTY51_10630	COG0649	NAD binding
HTY51_10635	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTY51_10640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTY51_10645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HTY51_10660	COG0149	triose-phosphate isomerase activity
HTY51_10665	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_10665	COG0604	alcohol dehydrogenase
HTY51_10665	COG3321	synthase
HTY51_10670	COG1185	polyribonucleotide nucleotidyltransferase activity
HTY51_10675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HTY51_10680	COG0436	Aminotransferase
HTY51_10695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HTY51_10700	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_10710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY51_10715	COG1116	anion transmembrane transporter activity
HTY51_10735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HTY51_10740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY51_10745	COG1116	anion transmembrane transporter activity
HTY51_10750	COG2223	nitrite transmembrane transporter activity
HTY51_10770	COG0515	serine threonine protein kinase
HTY51_10770	COG2815	serine threonine protein kinase
HTY51_10775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HTY51_10785	COG2146	nitrite reductase [NAD(P)H] activity
HTY51_10790	COG0243	molybdopterin cofactor binding
HTY51_10810	COG2081	HI0933 family
HTY51_10815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HTY51_10820	COG1610	YqeY-like protein
HTY51_10840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTY51_10845	COG0385	Bile acid
HTY51_10850	COG2072	flavoprotein involved in K transport
HTY51_10855	COG0300	oxidoreductase activity
HTY51_10860	COG1414	Transcriptional regulator
HTY51_10870	COG4948	Mandelate Racemase Muconate Lactonizing
HTY51_10880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HTY51_10885	COG2186	Transcriptional regulator
HTY51_10890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTY51_10895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HTY51_10910	COG4948	Mandelate Racemase Muconate Lactonizing
HTY51_10920	COG2706	6-phosphogluconolactonase activity
HTY51_10925	COG2721	sulfolactate sulfo-lyase activity
HTY51_10940	COG0312	modulator of DNA gyrase
HTY51_10945	COG3028	Belongs to the UPF0307 family
HTY51_10950	COG0521	Mo-molybdopterin cofactor biosynthetic process
HTY51_10960	COG1045	serine acetyltransferase
HTY51_10975	COG5001	Diguanylate cyclase
HTY51_10985	COG3046	protein related to deoxyribodipyrimidine photolyase
HTY51_11005	COG0546	phosphoglycolate phosphatase activity
HTY51_11010	COG3842	ATPase activity
HTY51_11015	COG1175	transmembrane transport
HTY51_11040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTY51_11045	COG0653	protein targeting
HTY51_11080	COG0515	serine threonine protein kinase
HTY51_11080	COG2815	serine threonine protein kinase
HTY51_11090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HTY51_11100	COG1968	undecaprenyl-diphosphatase activity
HTY51_11110	COG2203	Gaf domain
HTY51_11110	COG3706	GGDEF domain
HTY51_11110	COG4251	negative regulation of phosphorylation
HTY51_11110	COG5001	Diguanylate cyclase
HTY51_11115	COG0577	efflux transmembrane transporter activity
HTY51_11115	COG1136	(ABC) transporter
HTY51_11120	COG1136	(ABC) transporter
HTY51_11140	COG3275	phosphorelay sensor kinase activity
HTY51_11145	COG3279	Response regulator of the LytR AlgR family
HTY51_11160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HTY51_11305	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_11310	COG3618	amidohydrolase
HTY51_11315	COG0583	DNA-binding transcription factor activity
HTY51_11345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HTY51_11370	COG0181	hydroxymethylbilane synthase activity
HTY51_11375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HTY51_11385	COG0720	synthase
HTY51_11390	COG0602	queuosine metabolic process
HTY51_11400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HTY51_11490	COG0425	Belongs to the sulfur carrier protein TusA family
HTY51_11500	COG0525	valine-tRNA ligase activity
HTY51_11510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HTY51_11530	COG0564	pseudouridine synthase activity
HTY51_11535	COG3022	response to hydroperoxide
HTY51_11540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HTY51_11540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HTY51_11545	COG0840	transmembrane signaling receptor activity
HTY51_11555	COG1250	3-hydroxyacyl-CoA dehydrogenase
HTY51_11555	COG1024	Enoyl-CoA hydratase
HTY51_11590	COG0583	DNA-binding transcription factor activity
HTY51_11645	COG2010	Cytochrome c
HTY51_11665	COG3171	Protein conserved in bacteria
HTY51_11690	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_11700	COG1414	Transcriptional regulator
HTY51_11730	COG0523	cobalamin synthesis protein
HTY51_11735	COG1414	Transcriptional regulator
HTY51_11765	COG2132	Multicopper oxidase
HTY51_11795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HTY51_11830	COG1304	FMN binding
HTY51_11835	COG0205	6-phosphofructokinase activity
HTY51_11845	COG0165	Argininosuccinate lyase
HTY51_11850	COG3275	phosphorelay sensor kinase activity
HTY51_11860	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HTY51_11865	COG1674	ftsk spoiiie
HTY51_11880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HTY51_11885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HTY51_11900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HTY51_11905	COG1666	GTP binding
HTY51_11920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HTY51_11930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HTY51_11945	COG0667	Aldo Keto reductase
HTY51_11975	COG0308	aminopeptidase N
HTY51_11980	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HTY51_12000	COG3384	dioxygenase
HTY51_12020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HTY51_12045	COG0285	dihydrofolate synthase activity
HTY51_12050	COG1393	Belongs to the ArsC family
HTY51_12055	COG3123	guanosine phosphorylase activity
HTY51_12060	COG0137	argininosuccinate synthase activity
HTY51_12075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HTY51_12075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HTY51_12085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HTY51_12090	COG3132	Protein of unknown function, DUF480
HTY51_12095	COG1960	acyl-CoA dehydrogenase activity
HTY51_12105	COG0840	transmembrane signaling receptor activity
HTY51_12115	COG5002	protein histidine kinase activity
HTY51_12115	COG0784	Response regulator, receiver
HTY51_12115	COG2205	protein histidine kinase activity
HTY51_12125	COG4974	Belongs to the 'phage' integrase family
HTY51_12145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HTY51_12165	COG0196	riboflavin kinase activity
HTY51_12170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HTY51_12175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HTY51_12180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HTY51_12195	COG0697	spore germination
HTY51_12200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HTY51_12205	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_12235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HTY51_12250	COG0084	hydrolase, TatD family'
HTY51_12255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HTY51_12260	COG0714	Associated with various cellular activities
HTY51_12270	COG2304	oxidoreductase activity
HTY51_12285	COG1136	(ABC) transporter
HTY51_12290	COG4591	ABC-type transport system involved in lipoprotein release permease component
HTY51_12300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HTY51_12305	COG3706	GGDEF domain
HTY51_12310	COG0613	PHP domain protein
HTY51_12320	COG0009	L-threonylcarbamoyladenylate synthase
HTY51_12325	COG1994	Peptidase M50
HTY51_12330	COG0180	Tryptophanyl-tRNA synthetase
HTY51_12335	COG2207	Transcriptional regulator
HTY51_12360	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_12375	COG0583	DNA-binding transcription factor activity
HTY51_12385	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_12410	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_12420	COG0300	oxidoreductase activity
HTY51_12430	COG0642	Histidine kinase
HTY51_12435	COG0745	RESPONSE REGULATOR receiver
HTY51_12440	COG4251	negative regulation of phosphorylation
HTY51_12440	COG5001	Diguanylate cyclase
HTY51_12440	COG3706	GGDEF domain
HTY51_12440	COG2203	Gaf domain
HTY51_12445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTY51_12450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HTY51_12455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HTY51_12460	COG1047	Peptidyl-prolyl cis-trans
HTY51_12465	COG2003	Belongs to the UPF0758 family
HTY51_12470	COG1193	negative regulation of DNA recombination
HTY51_12480	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HTY51_12485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HTY51_12505	COG0437	4 iron, 4 sulfur cluster binding
HTY51_12510	COG0243	molybdopterin cofactor binding
HTY51_12510	COG3383	formate dehydrogenase (NAD+) activity
HTY51_12520	COG2204	response regulator
HTY51_12525	COG4191	Histidine kinase
HTY51_12555	COG3383	formate dehydrogenase (NAD+) activity
HTY51_12565	COG0583	DNA-binding transcription factor activity
HTY51_12570	COG0489	protein tyrosine kinase activity
HTY51_12580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY51_12580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HTY51_12595	COG4251	negative regulation of phosphorylation
HTY51_12595	COG3706	GGDEF domain
HTY51_12595	COG2203	Gaf domain
HTY51_12595	COG5001	Diguanylate cyclase
HTY51_12605	COG0659	secondary active sulfate transmembrane transporter activity
HTY51_12620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HTY51_12625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HTY51_12630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HTY51_12635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HTY51_12640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HTY51_12650	COG0686	Belongs to the AlaDH PNT family
HTY51_12670	COG2020	methyltransferase activity
HTY51_12675	COG0742	ribosomal rna small subunit methyltransferase
HTY51_12680	COG0612	Peptidase, M16
HTY51_12685	COG0612	Peptidase, M16
HTY51_12720	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HTY51_12740	COG1136	(ABC) transporter
HTY51_12765	COG4628	conserved protein (DUF2132)
HTY51_12775	COG0829	nickel cation binding
HTY51_12780	COG0583	DNA-binding transcription factor activity
HTY51_12785	COG0400	carboxylic ester hydrolase activity
HTY51_12790	COG3384	dioxygenase
HTY51_12800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HTY51_12805	COG2132	Multicopper oxidase
HTY51_12825	COG2824	Alkylphosphonate utilization operon protein PhnA
HTY51_12850	COG4941	Belongs to the sigma-70 factor family
HTY51_12865	COG3795	YCII-related domain
HTY51_12870	COG3795	YCII-related domain
HTY51_12880	COG0835	chemotaxis
HTY51_12900	COG0840	transmembrane signaling receptor activity
HTY51_12905	COG0745	RESPONSE REGULATOR receiver
HTY51_12910	COG0784	Response regulator, receiver
HTY51_12910	COG4191	Histidine kinase
HTY51_12965	COG1704	LemA family
HTY51_12970	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HTY51_13025	COG0154	amidase activity
HTY51_13030	COG1309	transcriptional regulator
HTY51_13035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HTY51_13040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HTY51_13070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HTY51_13090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HTY51_13100	COG5002	protein histidine kinase activity
HTY51_13100	COG2198	Histidine kinase
HTY51_13100	COG0784	Response regulator, receiver
HTY51_13110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HTY51_13135	COG0784	Response regulator, receiver
HTY51_13135	COG2198	Histidine kinase
HTY51_13135	COG2205	protein histidine kinase activity
HTY51_13155	COG3842	ATPase activity
HTY51_13160	COG0410	ABC transporter
HTY51_13175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HTY51_13190	COG0831	urea catabolic process
HTY51_13205	COG0832	Belongs to the urease beta subunit family
HTY51_13210	COG0804	urea catabolic process
HTY51_13215	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HTY51_13220	COG0830	nickel cation binding
HTY51_13225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HTY51_13250	COG3239	Fatty acid desaturase
HTY51_13260	COG1047	Peptidyl-prolyl cis-trans
HTY51_13275	COG0714	Associated with various cellular activities
HTY51_13280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HTY51_13285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTY51_13290	COG1253	flavin adenine dinucleotide binding
HTY51_13295	COG0741	lytic transglycosylase activity
HTY51_13300	COG0442	prolyl-tRNA aminoacylation
HTY51_13305	COG0494	nUDIX hydrolase
HTY51_13310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HTY51_13315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HTY51_13320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HTY51_13325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HTY51_13330	COG0142	geranyltranstransferase activity
HTY51_13355	COG0237	dephospho-CoA kinase activity
HTY51_13360	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HTY51_13365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HTY51_13370	COG1051	belongs to the nudix hydrolase family
HTY51_13380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HTY51_13385	COG0653	protein targeting
HTY51_13405	COG2969	positive regulation of protein catabolic process
HTY51_13410	COG0625	glutathione transferase activity
HTY51_13415	COG2857	Cytochrome c1
HTY51_13420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HTY51_13425	COG0723	plastoquinol--plastocyanin reductase activity
HTY51_13430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HTY51_13435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HTY51_13450	COG0805	protein transport
HTY51_13455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTY51_13460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HTY51_13465	COG0537	adenosine 5'-monophosphoramidase activity
HTY51_13470	COG0140	phosphoribosyl-ATP diphosphatase activity
HTY51_13475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HTY51_13480	COG0107	imidazoleglycerol-phosphate synthase activity
HTY51_13490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HTY51_13500	COG0131	Imidazoleglycerol-phosphate dehydratase
HTY51_13505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HTY51_13510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HTY51_13515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HTY51_13520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HTY51_13525	COG5007	Belongs to the BolA IbaG family
HTY51_13530	COG0842	Transport permease protein
HTY51_13535	COG1131	(ABC) transporter
HTY51_13550	COG2853	Lipoprotein
HTY51_13555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HTY51_13560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HTY51_13565	COG1127	ABC transporter
HTY51_13575	COG0067	glutamate synthase
HTY51_13575	COG0070	glutamate synthase
HTY51_13575	COG0069	glutamate synthase activity
HTY51_13605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HTY51_13610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HTY51_13615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HTY51_13650	COG1965	Belongs to the frataxin family
HTY51_13670	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HTY51_13675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HTY51_13680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HTY51_13685	COG1333	cytochrome c biogenesis protein
HTY51_13695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HTY51_13715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HTY51_13745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HTY51_13750	COG0459	protein refolding
HTY51_13755	COG0166	Belongs to the GPI family
HTY51_13760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HTY51_13785	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HTY51_13795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HTY51_13800	COG1024	Enoyl-CoA hydratase
HTY51_13825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HTY51_13830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HTY51_13835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HTY51_13860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTY51_13860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HTY51_13865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HTY51_13875	COG1872	DUF167
HTY51_13880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HTY51_13890	COG2264	protein methyltransferase activity
HTY51_13895	COG0439	Biotin carboxylase
HTY51_13900	COG0511	ligase activity, forming carbon-carbon bonds
HTY51_13905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY51_13915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HTY51_13920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HTY51_13925	COG0312	modulator of DNA gyrase
HTY51_13930	COG2084	Dehydrogenase
HTY51_13935	COG0772	Belongs to the SEDS family
HTY51_13950	COG3150	esterase
HTY51_13955	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HTY51_13965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HTY51_13970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HTY51_13990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HTY51_14010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HTY51_14020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HTY51_14025	COG1181	Belongs to the D-alanine--D-alanine ligase family
HTY51_14030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HTY51_14035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HTY51_14040	COG0772	Belongs to the SEDS family
HTY51_14045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HTY51_14050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HTY51_14055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HTY51_14060	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HTY51_14075	COG0275	rRNA processing
HTY51_14080	COG2001	Belongs to the MraZ family
HTY51_14085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HTY51_14090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HTY51_14105	COG0523	cobalamin synthesis protein
HTY51_14115	COG0840	transmembrane signaling receptor activity
HTY51_14120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HTY51_14130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HTY51_14165	COG0583	DNA-binding transcription factor activity
HTY51_14170	COG1959	2 iron, 2 sulfur cluster binding
HTY51_14180	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HTY51_14195	COG0501	Belongs to the peptidase M48B family
HTY51_14205	COG0418	dihydroorotase activity
HTY51_14210	COG1126	abc transporter atp-binding protein
HTY51_14215	COG0765	amino acid transport
HTY51_14220	COG0765	amino acid transport
HTY51_14225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HTY51_14235	COG5265	(ABC) transporter
HTY51_14240	COG1607	acyl-coa hydrolase
HTY51_14245	COG2050	protein possibly involved in aromatic compounds catabolism
HTY51_14265	COG0183	Belongs to the thiolase family
HTY51_14270	COG1250	3-hydroxyacyl-CoA dehydrogenase
HTY51_14270	COG1024	Enoyl-CoA hydratase
HTY51_14280	COG1960	acyl-CoA dehydrogenase activity
HTY51_14295	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTY51_14300	COG1309	transcriptional regulator
HTY51_14305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HTY51_14320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HTY51_14340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HTY51_14385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HTY51_14395	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_14400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HTY51_14410	COG1083	cytidylyl-transferase
HTY51_14415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HTY51_14420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HTY51_14425	COG2089	acid synthase
HTY51_14435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HTY51_14440	COG1088	dTDP-glucose 4,6-dehydratase activity
HTY51_14445	COG1132	(ABC) transporter
HTY51_14450	COG3039	Transposase
HTY51_14455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HTY51_14480	COG1091	dTDP-4-dehydrorhamnose reductase activity
HTY51_14510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HTY51_14565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY51_14570	COG4772	TonB-dependent receptor
HTY51_14595	COG1187	pseudouridine synthase activity
HTY51_14600	COG0326	Molecular chaperone. Has ATPase activity
HTY51_14635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HTY51_14645	COG0515	serine threonine protein kinase
HTY51_14645	COG2815	serine threonine protein kinase
HTY51_14675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HTY51_14675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HTY51_14675	COG1703	isobutyryl-CoA mutase activity
HTY51_14690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HTY51_14695	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTY51_14700	COG3453	Protein conserved in bacteria
HTY51_14700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY51_14705	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HTY51_14710	COG1473	amidohydrolase
HTY51_14725	COG0203	ribosomal protein L17
HTY51_14730	COG0202	RNA polymerase activity
HTY51_14735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HTY51_14740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HTY51_14745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HTY51_14750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HTY51_14760	COG0201	protein transport
HTY51_14765	COG0200	Binds to the 23S rRNA
HTY51_14770	COG1841	ribosomal large subunit assembly
HTY51_14775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HTY51_14780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HTY51_14785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HTY51_14790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HTY51_14795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HTY51_14800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HTY51_14805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HTY51_14810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HTY51_14815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HTY51_14830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HTY51_14835	COG0783	Belongs to the Dps family
HTY51_14855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HTY51_14860	COG1902	pentaerythritol trinitrate reductase activity
HTY51_14870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HTY51_14875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HTY51_14885	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HTY51_14890	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HTY51_14900	COG0235	Class ii aldolase
HTY51_14905	COG0343	queuine tRNA-ribosyltransferase activity
HTY51_14910	COG1595	DNA-templated transcription, initiation
HTY51_14925	COG4651	solute:proton antiporter activity
HTY51_14925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HTY51_14940	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HTY51_14965	COG3639	organic phosphonate transmembrane transporter activity
HTY51_14970	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HTY51_14975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HTY51_14980	COG3454	Phosphonate metabolism
HTY51_14985	COG4778	phosphonate C-P lyase system protein PhnL
HTY51_14990	COG4107	phosphonate C-P lyase system protein PhnK
HTY51_15000	COG3627	carbon phosphorus lyase activity
HTY51_15005	COG3626	phosphonate metabolism
HTY51_15010	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HTY51_15015	COG3624	Phosphonate C-P lyase system protein PhnG
HTY51_15020	COG2188	Transcriptional regulator
HTY51_15025	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HTY51_15030	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HTY51_15045	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_15045	COG0204	Acyl-transferase
HTY51_15060	COG0446	pyridine nucleotide-disulphide oxidoreductase
HTY51_15095	COG0179	Fumarylacetoacetate (FAA) hydrolase
HTY51_15130	COG1999	signal sequence binding
HTY51_15150	COG4948	Mandelate Racemase Muconate Lactonizing
HTY51_15155	COG0583	DNA-binding transcription factor activity
HTY51_15190	COG1324	tolerance protein
HTY51_15205	COG0688	phosphatidylethanolamine metabolic process
HTY51_15210	COG0277	FAD linked oxidase domain protein
HTY51_15215	COG1380	Effector of murein hydrolase LrgA
HTY51_15220	COG1346	cytolysis
HTY51_15225	COG3300	MHYT domain
HTY51_15225	COG5001	Diguanylate cyclase
HTY51_15235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HTY51_15245	COG1355	regulation of microtubule-based process
HTY51_15270	COG0010	Belongs to the arginase family
HTY51_15280	COG4968	Prepilin-type N-terminal cleavage methylation domain
HTY51_15290	COG0596	Alpha beta hydrolase
HTY51_15295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTY51_15320	COG2084	Dehydrogenase
HTY51_15330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HTY51_15335	COG0792	nuclease activity
HTY51_15345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HTY51_15350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HTY51_15355	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_15380	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_15400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HTY51_15405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HTY51_15410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HTY51_15415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HTY51_15420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HTY51_15425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HTY51_15435	COG0356	it plays a direct role in the translocation of protons across the membrane
HTY51_15450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HTY51_15455	COG2921	Belongs to the UPF0250 family
HTY51_15460	COG0321	lipoyl(octanoyl) transferase activity
HTY51_15465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HTY51_15475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HTY51_15480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HTY51_15505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HTY51_15520	COG0501	Belongs to the peptidase M48B family
HTY51_15525	COG0456	acetyltransferase
HTY51_15530	COG0678	peroxiredoxin activity
HTY51_15535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HTY51_15540	COG0255	Belongs to the universal ribosomal protein uL29 family
HTY51_15545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HTY51_15550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HTY51_15555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HTY51_15560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HTY51_15565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HTY51_15570	COG0089	rRNA binding
HTY51_15575	COG0088	Forms part of the polypeptide exit tunnel
HTY51_15580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HTY51_15585	COG0051	transcription antitermination factor activity, RNA binding
HTY51_15595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HTY51_15600	COG0049	tRNA binding
HTY51_15605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HTY51_15610	COG1686	Belongs to the peptidase S11 family
HTY51_15615	COG2945	thiolester hydrolase activity
HTY51_15640	COG0598	Magnesium transport protein CorA
HTY51_15655	COG0412	Dienelactone hydrolase
HTY51_15665	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_15670	COG2030	dehydratase
HTY51_15675	COG2095	MarC family integral membrane protein
HTY51_15685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HTY51_15695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HTY51_15710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HTY51_15715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HTY51_15720	COG1024	Enoyl-CoA hydratase
HTY51_15725	COG0471	metal ion transport
HTY51_15730	COG0583	DNA-binding transcription factor activity
HTY51_15755	COG0768	penicillin binding
HTY51_15770	COG1077	Cell shape determining protein MreB Mrl
HTY51_15775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTY51_15780	COG0154	amidase activity
HTY51_15785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HTY51_15795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HTY51_15800	COG0708	Exodeoxyribonuclease III
HTY51_15810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HTY51_15825	COG2211	Major facilitator Superfamily
HTY51_15835	COG2205	protein histidine kinase activity
HTY51_15865	COG0656	L-ascorbic acid biosynthetic process
HTY51_15880	COG1846	Transcriptional regulator
HTY51_15895	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_15900	COG3384	dioxygenase
HTY51_15910	COG3971	2-oxopent-4-enoate hydratase activity
HTY51_15925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HTY51_15945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HTY51_15960	COG0386	Belongs to the glutathione peroxidase family
HTY51_15965	COG0247	lactate metabolic process
HTY51_15970	COG0277	FAD linked oxidase domain protein
HTY51_15975	COG0004	ammonium transporteR
HTY51_15980	COG0347	Belongs to the P(II) protein family
HTY51_16010	COG0646	methionine synthase
HTY51_16010	COG1410	methionine synthase
HTY51_16020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HTY51_16025	COG0861	Integral membrane protein TerC family
HTY51_16050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HTY51_16055	COG3842	ATPase activity
HTY51_16065	COG0725	ABC transporter, periplasmic molybdate-binding protein
HTY51_16070	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HTY51_16095	COG2866	Carboxypeptidase
HTY51_16100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HTY51_16105	COG0697	spore germination
HTY51_16120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HTY51_16125	COG1960	acyl-CoA dehydrogenase activity
HTY51_16130	COG0583	DNA-binding transcription factor activity
HTY51_16135	COG3706	GGDEF domain
HTY51_16140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HTY51_16155	COG5001	Diguanylate cyclase
HTY51_16170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HTY51_16175	COG2233	PERMEase
HTY51_16185	COG2096	Adenosyltransferase
HTY51_16190	COG0277	FAD linked oxidase domain protein
HTY51_16230	COG1475	DNA binding
HTY51_16240	COG1192	Involved in chromosome partitioning
HTY51_16250	COG0357	Ribosomal RNA small subunit methyltransferase G
HTY51_16255	COG0445	tRNA wobble uridine modification
HTY51_16265	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_16320	COG0840	transmembrane signaling receptor activity
HTY51_16325	COG2217	Heavy metal translocating P-type atpase
HTY51_16345	COG3706	GGDEF domain
HTY51_16380	COG2176	DNA-directed DNA polymerase activity
HTY51_16400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HTY51_16405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HTY51_16410	COG0594	ribonuclease P activity
HTY51_16415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HTY51_16420	COG0706	membrane insertase activity
HTY51_16425	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HTY51_16435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HTY51_16450	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HTY51_16460	COG0300	oxidoreductase activity
HTY51_16465	COG0724	RNA recognition motif
HTY51_16485	COG3220	belongs to the UPF0276 family
HTY51_16500	COG0004	ammonium transporteR
HTY51_16505	COG0789	Transcriptional regulator
HTY51_16510	COG1742	UPF0060 membrane protein
HTY51_16520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HTY51_16585	COG5002	protein histidine kinase activity
HTY51_16635	COG2217	Heavy metal translocating P-type atpase
HTY51_16645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HTY51_16650	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HTY51_16695	COG2129	metallophosphoesterase
HTY51_16705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HTY51_16745	COG2119	membrane
HTY51_16750	COG2116	formate transmembrane transporter activity
HTY51_16755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HTY51_16760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HTY51_16760	COG2813	Specifically methylates the guanine in position
HTY51_16770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HTY51_16780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HTY51_16790	COG2267	carboxylic ester hydrolase activity
HTY51_16795	COG2814	Major facilitator Superfamily
HTY51_16800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HTY51_16810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HTY51_16815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HTY51_16820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HTY51_16835	COG4290	ribonuclease
HTY51_16840	COG0280	phosphate acetyltransferase
HTY51_16840	COG0281	malic enzyme
HTY51_16890	COG0006	proline dipeptidase activity
HTY51_16900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HTY51_16905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HTY51_16915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HTY51_16915	COG0551	DNA topoisomerase type I activity
HTY51_16925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HTY51_16925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HTY51_16935	COG0642	Histidine kinase
HTY51_16950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HTY51_16955	COG2137	regulation of response to DNA damage stimulus
HTY51_16960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HTY51_16965	COG0045	succinate-CoA ligase (ADP-forming) activity
HTY51_16970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HTY51_16975	COG0861	Integral membrane protein TerC family
HTY51_16980	COG0631	protein serine/threonine phosphatase activity
HTY51_16985	COG1716	ATPase activity
HTY51_16995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HTY51_17005	COG3307	-O-antigen
HTY51_17015	COG0315	cyclic pyranopterin monophosphate synthase activity
HTY51_17025	COG4783	chaperone-mediated protein folding
HTY51_17030	COG1950	PFAM Membrane protein of
HTY51_17035	COG0861	Integral membrane protein TerC family
HTY51_17055	COG0625	glutathione transferase activity
HTY51_17070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HTY51_17075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HTY51_17095	COG4566	intracellular signal transduction
HTY51_17115	COG1522	sequence-specific DNA binding
HTY51_17125	COG1862	Preprotein translocase
HTY51_17130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HTY51_17145	COG2922	Belongs to the Smg family
HTY51_17150	COG0758	DNA mediated transformation
HTY51_17160	COG0242	peptide deformylase activity
HTY51_17165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HTY51_17180	COG0126	phosphoglycerate kinase activity
HTY51_17185	COG0469	pyruvate kinase activity
HTY51_17195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HTY51_17200	COG3118	belongs to the thioredoxin family
HTY51_17205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HTY51_17210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HTY51_17215	COG0009	L-threonylcarbamoyladenylate synthase
HTY51_17220	COG4095	Psort location CytoplasmicMembrane, score
HTY51_17225	COG2027	D-alanyl-D-alanine carboxypeptidase
HTY51_17245	COG1573	uracil-dna glycosylase
HTY51_17255	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HTY51_17275	COG0284	orotidine-5'-phosphate decarboxylase activity
HTY51_17290	COG2814	Major facilitator Superfamily
HTY51_17300	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_17310	COG4948	Mandelate Racemase Muconate Lactonizing
HTY51_17320	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_17350	COG1937	Protein conserved in bacteria
HTY51_17355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HTY51_17380	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HTY51_17385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HTY51_17415	COG0482	sulfurtransferase activity
HTY51_17450	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_17460	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_17480	COG1053	succinate dehydrogenase
HTY51_17480	COG3976	FMN-binding domain protein
HTY51_17490	COG1053	succinate dehydrogenase
HTY51_17510	COG1012	belongs to the aldehyde dehydrogenase family
HTY51_17520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HTY51_17530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HTY51_17535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HTY51_17540	COG0318	PFAM AMP-dependent synthetase and ligase
HTY51_17550	COG0598	Magnesium transport protein CorA
HTY51_17555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HTY51_17565	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HTY51_17570	COG0735	belongs to the Fur family
HTY51_17575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HTY51_17580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HTY51_17585	COG0495	leucyl-tRNA aminoacylation
HTY51_17600	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HTY51_17615	COG3158	transport of potassium into the cell
HTY51_17620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HTY51_17630	COG0018	arginyl-trna synthetase
HTY51_17650	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HTY51_17655	COG1960	acyl-CoA dehydrogenase activity
HTY51_17695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HTY51_17700	COG0604	alcohol dehydrogenase
HTY51_17705	COG1028	Short-chain dehydrogenase reductase Sdr
HTY51_17710	COG1309	transcriptional regulator
HTY51_17715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HTY51_17780	COG0523	cobalamin synthesis protein
HTY51_17785	COG1414	Transcriptional regulator
HTY51_17790	COG1063	alcohol dehydrogenase
HTY51_17800	COG3181	Tripartite tricarboxylate transporter family receptor
HTY51_17830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HTY51_17835	COG2814	Major facilitator Superfamily
HTY51_17840	COG0121	glutamine amidotransferase
HTY51_17845	COG0840	transmembrane signaling receptor activity
HTY51_17850	COG0189	ligase activity
HTY51_17855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HTY51_17860	COG1137	ATPase activity
HTY51_17865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HTY51_17880	COG0653	protein targeting
HTY51_17885	COG0596	Alpha beta hydrolase
HTY51_17920	COG2967	ApaG domain
HTY51_17925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HTY51_17945	COG0512	Glutamine amidotransferase of anthranilate synthase
HTY51_17950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HTY51_17955	COG0134	indole-3-glycerol-phosphate synthase activity
HTY51_18000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HTY51_18005	COG0081	regulation of translation
HTY51_18010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HTY51_18015	COG0222	ribosome binding
HTY51_18020	COG0085	RNA polymerase activity
HTY51_18025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HTY51_18040	COG5000	phosphorelay sensor kinase activity
HTY51_18045	COG2204	response regulator
HTY51_18065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HTY51_18075	COG0210	DNA helicase
HTY51_18085	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HTY51_18095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HTY51_18100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HTY51_18110	COG1832	CoA-binding protein
HTY51_18115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTY51_18120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HTY51_18130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HTY51_18160	COG2900	Belongs to the SlyX family
HTY51_18170	COG0583	DNA-binding transcription factor activity
HTY51_18205	COG0384	phenazine biosynthesis protein PhzF
HTY51_18210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HTY51_18215	COG0697	spore germination
HTY51_18235	COG1705	Flagellar rod assembly protein muramidase FlgJ
HTY51_18235	COG3951	Flagellar rod assembly protein muramidase FlgJ
HTY51_18240	COG1706	bacterial-type flagellum-dependent cell motility
HTY51_18255	COG4787	bacterial-type flagellum-dependent cell motility
HTY51_18260	COG1749	Flagellar hook protein flgE
HTY51_18270	COG1558	bacterial-type flagellum-dependent cell motility
HTY51_18275	COG1815	bacterial-type flagellum-dependent cell motility
HTY51_18305	COG1191	sigma factor activity
HTY51_18315	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HTY51_18320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HTY51_18325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HTY51_18330	COG0745	RESPONSE REGULATOR receiver
HTY51_18355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HTY51_18365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HTY51_18435	COG1766	The M ring may be actively involved in energy transduction
HTY51_18475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation