locus-tag class description E5N89_00005 ENOG4105CFH Aspartokinase E5N89_00015 ENOG4105D98 threonine synthase E5N89_00025 ENOG4105BZG amino acid carrier protein E5N89_00035 ENOG4108RIR Molybdenum cofactor biosynthesis protein E5N89_00040 ENOG4106HK8 GPR1 FUN34 yaaH family protein E5N89_00045 ENOG4108QUJ UPF0174 protein YaaW E5N89_00050 ENOG4108WTA UPF0412 protein YaaI E5N89_00105 ENOG4108AF8 Chaperone E5N89_00110 ENOG4105CW0 outer membrane usher protein E5N89_00115 ENOG4105MHR Fimbrial protein E5N89_00130 ENOG4106PH7 chaperone E5N89_00150 ENOG4105DQS Transcriptional regulator E5N89_00165 ENOG4105CGH 5'-nucleotidase E5N89_00175 ENOG41061MV Arylsulfatase E5N89_00180 ENOG4105C4X radical SAM domain protein E5N89_00200 ENOG41063Z6 transcriptional regulator, lysR family E5N89_00220 ENOG410647N response to DNA damage stimulus E5N89_00225 ENOG4105DTN riboflavin biosynthesis protein ribF E5N89_00230 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E5N89_00240 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E5N89_00260 ENOG4106YYS transcriptional regulatory protein E5N89_00265 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E5N89_00270 ENOG4105D9Q decarboxylase (Beta subunit) E5N89_00275 ENOG4107QSA Oxaloacetate decarboxylase E5N89_00280 ENOG4106AFN Lyase and sodium transporter (By similarity) E5N89_00290 ENOG4105DUA (citrate (pro-3S)-lyase ligase E5N89_00300 ENOG4105CI0 Citrate lyase E5N89_00305 ENOG4105CHY citrate lyase, alpha E5N89_00320 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) E5N89_00330 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E5N89_00335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E5N89_00340 ENOG4108XNW Transcriptional activatory protein CaiF E5N89_00345 ENOG4108Z0R Transferase E5N89_00390 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5N89_00395 ENOG4105WQV ferredoxin-like protein E5N89_00400 ENOG4105C54 Major Facilitator superfamily E5N89_00405 ENOG4105M5B (LipO)protein E5N89_00425 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF E5N89_00430 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5N89_00455 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E5N89_00465 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E5N89_00475 ENOG4105D3G Pseudouridine synthase E5N89_00480 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E5N89_00485 ENOG4105CQ2 DNA polymerase E5N89_00505 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E5N89_00515 ENOG4105EF1 ribulokinase E5N89_00520 ENOG41063TF transcriptional regulator (AraC E5N89_00525 ENOG4108KF1 Membrane E5N89_00530 ENOG4107T0D ABC, transporter E5N89_00535 ENOG4106SMU thiamine transporter membrane protein E5N89_00540 ENOG4105DP9 ABC transporter E5N89_00545 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E5N89_00555 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N89_00560 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N89_00580 ENOG41064T2 transcriptional regulator, lysR family E5N89_00585 ENOG4105C7K acetolactate synthase E5N89_00590 ENOG4108ZP8 Acetolactate synthase small subunit E5N89_00595 ENOG4107B7Y DNA-binding transcriptional regulator FruR E5N89_00610 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E5N89_00615 ENOG4105CJN penicillin-binding protein E5N89_00620 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E5N89_00625 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E5N89_00635 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) E5N89_00640 ENOG4105CNI cell division protein FtsW E5N89_00655 ENOG4105CPF Cell wall formation (By similarity) E5N89_00660 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E5N89_00665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E5N89_00670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E5N89_00680 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) E5N89_00690 ENOG4105M6F mutator MutT protein E5N89_00715 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E5N89_00725 ENOG4105D7Q type ii secretion system E5N89_00730 ENOG4107QHF type ii secretion system protein e E5N89_00735 ENOG4108ZUW Major pilin subunit E5N89_00745 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E5N89_00755 ENOG4106A72 regulatory protein AmpE E5N89_00760 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) E5N89_00765 ENOG4105CT4 transporter E5N89_00770 ENOG4105C85 amino acid E5N89_00775 ENOG41073TP transcriptional regulator E5N89_00780 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E5N89_00785 ENOG4107QSN dihydrolipoamide acetyltransferase E5N89_00790 ENOG4107QN2 dihydrolipoyl dehydrogenase E5N89_00805 ENOG4108NST exported protein E5N89_00810 ENOG4107QIJ Aconitate hydratase 2 E5N89_00825 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E5N89_00830 ENOG4107S2N Type III effector Hrp-dependent E5N89_00835 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E5N89_00840 ENOG4105MVE transcriptional regulator E5N89_00855 ENOG4108ZRK uncharacterized protein yacC E5N89_00860 ENOG4105E3B Multicopper oxidase E5N89_00865 ENOG4105DZG Dehydrogenase E5N89_00870 ENOG4108UGV hypoxanthine phosphoribosyltransferase E5N89_00875 ENOG41077A9 carbonic anhydrase E5N89_00880 ENOG4105DA5 (ABC) transporter E5N89_00885 ENOG4105E3A (ABC) transporter E5N89_00890 ENOG4108MDY Fimbrial E5N89_00895 ENOG4105CW0 outer membrane usher protein E5N89_00900 ENOG4108UIF Chaperone E5N89_00910 ENOG4108YTN IIa component E5N89_00915 ENOG4107BJW polysaccharide deacetylase E5N89_00925 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) E5N89_00935 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E5N89_00940 ENOG4105DJ0 Poly(A) Polymerase E5N89_00945 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E5N89_00950 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E5N89_00960 ENOG4107XID 2'-5' rna ligase E5N89_00965 ENOG4105CQ7 ATP-dependent helicase E5N89_00970 ENOG4105BZ4 penicillin-binding protein E5N89_00975 ENOG4105E0K tonB-dependent siderophore receptor E5N89_00980 ENOG4105E0A ABC, transporter E5N89_00985 ENOG4105J76 Periplasmic binding protein E5N89_00990 ENOG4105S6R Iron-hydroxamate transporter permease subunit E5N89_01005 ENOG4106PG1 outer membrane usher protein E5N89_01010 ENOG4108FZ9 Chaperone E5N89_01015 ENOG4105NEV Fimbrial E5N89_01020 ENOG4105UGQ Fimbrial E5N89_01030 ENOG4106RDH Protein of unknown function (DUF2544) E5N89_01040 ENOG4105CMQ Chloride channel E5N89_01050 ENOG4105EN6 Membrane E5N89_01055 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E5N89_01065 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein E5N89_01070 ENOG4105C0H protease E5N89_01075 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E5N89_01085 ENOG4105CSH Transporter E5N89_01090 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) E5N89_01100 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E5N89_01135 ENOG4105KNE Phosphatidate cytidylyltransferase E5N89_01145 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5N89_01170 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5N89_01180 ENOG4105C0B DNA polymerase III (alpha subunit) E5N89_01190 ENOG4108M1A Chitin-binding protein E5N89_01195 ENOG4105CXN decarboxylase E5N89_01200 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase E5N89_01205 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E5N89_01210 ENOG4105M1T rho-binding antiterminator E5N89_01220 ENOG4108VWS Yaeq family E5N89_01225 ENOG4108YZN class I peptide chain release factor E5N89_01230 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion E5N89_01240 ENOG4108R96 Methyltransferase, YaeB family E5N89_01245 ENOG4108R8X outer membrane lipoprotein E5N89_01250 ENOG4105D01 (LipO)protein E5N89_01255 ENOG4108UMI ABC transporter, permease E5N89_01260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5N89_01265 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E5N89_01300 ENOG4105CV8 reductase E5N89_01305 ENOG4105HEI LysR family (Transcriptional regulator E5N89_01310 ENOG4105F27 Major Facilitator E5N89_01320 ENOG4105F2W methyltransferase E5N89_01325 ENOG4105E9H Lytic Murein transglycosylase E5N89_01330 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E5N89_01335 ENOG4105D1A Methyltransferase E5N89_01345 ENOG4108JDX DNA polymerase iii, epsilon subunit E5N89_01385 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5N89_01475 ENOG4105CS6 Rhs element vgr protein E5N89_01485 ENOG4107TV1 YD repeat protein E5N89_01495 ENOG4105CNA YD repeat protein E5N89_01515 ENOG4105CNA YD repeat protein E5N89_01565 ENOG4105W7K Transcriptional regulator E5N89_01575 ENOG4105T40 surface antigen msp4 family protein E5N89_01585 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E5N89_01590 ENOG4107QPN acyl-Coa dehydrogenase E5N89_01600 ENOG4105E7A Glutamine amidotransferase E5N89_01605 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E5N89_01620 ENOG4108S2Y peptide Chain Release factor E5N89_01625 ENOG4105CIN aminoacyl-histidine dipeptidase E5N89_01645 ENOG4105FCK Membrane E5N89_01655 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) E5N89_01670 ENOG4105DFP Integrase E5N89_01805 ENOG4105V2F Uncharacterized protein yoac E5N89_01810 ENOG4105D94 Major Facilitator Superfamily E5N89_01815 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N89_01820 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E5N89_01825 ENOG4105ERH Fumarylacetoacetate hydrolase E5N89_01835 ENOG4105EJC lysr family transcriptional regulator E5N89_01860 ENOG4105CW0 outer membrane usher protein E5N89_01865 ENOG4108VEV chaperone E5N89_01870 ENOG4105X0I Fimbrial E5N89_01885 ENOG4107XTP (EAL) domain protein E5N89_01900 ENOG4108T1M outer membrane protein x E5N89_01920 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5N89_01930 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5N89_01950 ENOG4105JHE Major Facilitator Superfamily E5N89_01955 ENOG4107QMH DNA methylase E5N89_01960 ENOG4105D8D Type III E5N89_01970 ENOG4105C4M (Ubiquinol oxidase) subunit I E5N89_01975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5N89_01995 ENOG4105E82 cytochrome subunit of dehydrogenase E5N89_02000 ENOG4105TDT uncharacterized protein yahO E5N89_02005 ENOG4108JU7 Transcriptional regulator E5N89_02010 ENOG4105CR4 methylisocitrate lyase E5N89_02015 ENOG4105BZN citrate synthase E5N89_02020 ENOG4105DXD 2-methylcitrate dehydratase E5N89_02025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E5N89_02030 ENOG4105D52 delta-aminolevulinic acid dehydratase E5N89_02035 ENOG4108NSE outer membrane autotransporter barrel E5N89_02040 ENOG4108PNB DNA-binding transcriptional regulator E5N89_02045 ENOG4107R6D beta-lactam binding protein AmpH E5N89_02055 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 E5N89_02060 ENOG4107QS8 (LipO)protein E5N89_02065 ENOG4105FR5 inner membrane protein YaiY E5N89_02070 ENOG4105UNH Membrane E5N89_02075 ENOG4105CPF Cell wall formation (By similarity) E5N89_02095 ENOG4105VIF phosphate starvation-inducible protein E5N89_02100 ENOG4105BZU Histidine kinase E5N89_02105 ENOG4105II7 pyrroline-5-carboxylate reductase E5N89_02120 ENOG4105SS3 E5N89_02125 ENOG4105HBA AroM protein E5N89_02140 ENOG4105DKQ ROK family E5N89_02145 ENOG4105F27 Major Facilitator E5N89_02150 ENOG4105EYH Exonuclease E5N89_02155 ENOG4107RH8 nuclease SbcCD subunit D E5N89_02160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5N89_02165 ENOG4105BZU Histidine kinase E5N89_02170 ENOG4105CWM branched-chain amino acid transport system II carrier protein E5N89_02175 ENOG4105C85 amino acid E5N89_02180 ENOG4107R28 alpha amylase, catalytic region E5N89_02185 ENOG4105D3R alkyl hydroperoxide reductase E5N89_02205 ENOG4105VIE preprotein translocase, subunit YajC E5N89_02215 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E5N89_02230 ENOG4105N1F Hnh endonuclease E5N89_02250 ENOG4105DRB nucleoside-specific channel-forming protein E5N89_02255 ENOG4108KIC (LipO)protein E5N89_02265 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E5N89_02275 ENOG4107YIM Involved in the transcription termination process (By similarity) E5N89_02280 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E5N89_02285 ENOG4108ZAI phosphatidylglycerophosphatase a E5N89_02290 ENOG4105CPC Aldo Keto reductase E5N89_02300 ENOG4105CTB Polyprenyl synthetase E5N89_02310 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) E5N89_02315 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component E5N89_02320 ENOG4108MP3 ABC transporter, permease E5N89_02325 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E5N89_02330 ENOG4105CY5 solute-binding protein E5N89_02335 ENOG4106S9K Transcriptional regulator E5N89_02340 ENOG4107STF Involved in phosphonate degradation (By similarity) E5N89_02345 ENOG4108KAZ Involved in phosphonate degradation (By similarity) E5N89_02350 ENOG4107S0N DJ-1 family E5N89_02355 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E5N89_02365 ENOG4107RDB Major Facilitator E5N89_02390 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E5N89_02395 ENOG4105CCU oxidase (Subunit III) E5N89_02400 ENOG4105BZ9 Cytochrome C oxidase, subunit I E5N89_02405 ENOG4105E2S oxidase) subunit II E5N89_02410 ENOG4105EYM Major Facilitator superfamily E5N89_02415 ENOG4105IEY (LipO)protein E5N89_02420 ENOG4105M85 Bola protein E5N89_02445 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) E5N89_02450 ENOG4105K70 DNA-binding protein E5N89_02455 ENOG4105EIN peptidylprolyl cis-trans isomerase E5N89_02460 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E5N89_02465 ENOG4108TGP Thioesterase superfamily protein E5N89_02475 ENOG4108NFA extracellular solute-binding protein E5N89_02485 ENOG4108RS6 transposase E5N89_02495 ENOG4108XM1 transcriptional regulator AsnC family E5N89_02500 ENOG4105BZ1 (ABC) transporter E5N89_02505 ENOG4105BZ1 (ABC) transporter E5N89_02515 ENOG4108YZA Nitrogen regulatory protein pii E5N89_02520 ENOG4105BZU Histidine kinase E5N89_02525 ENOG4105C29 acyl-CoA thioesterase E5N89_02530 ENOG4108MNP Glycoprotein polysaccharide metabolism E5N89_02535 ENOG41080UX Methyltransferase E5N89_02545 ENOG41066DG (EAL) domain protein E5N89_02560 ENOG4105GSJ Inner membrane protein ylaC E5N89_02565 ENOG4108UW5 maltose o-acetyltransferase E5N89_02575 ENOG4108UKR Biofilm formation regulator YbaJ E5N89_02580 ENOG4105BZS acriflavin resistance protein E5N89_02585 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5N89_02590 ENOG4108IG5 Transcriptional regulator E5N89_02595 ENOG4105EGS Mechanosensitive ion channel E5N89_02600 ENOG4105DNE Transposase E5N89_02605 ENOG4106428 Protein of unknown function (DUF2496) E5N89_02610 ENOG4108URS primosomal replication protein n'' E5N89_02615 ENOG4105WD1 Membrane E5N89_02625 ENOG4107QMP dna polymerase iii subunits gamma and tau E5N89_02640 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E5N89_02655 ENOG4105F2M alpha beta hydrolase fold-3 domain protein E5N89_02660 ENOG4107RE1 Inosine-guanosine kinase E5N89_02665 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5N89_02670 ENOG4105EU0 Major facilitator Superfamily E5N89_02675 ENOG4105CGH 5'-nucleotidase E5N89_02680 ENOG4108Z66 YbaK ebsC protein E5N89_02685 ENOG4105MBR gumn family E5N89_02695 ENOG4105C59 p-type ATPase E5N89_02700 ENOG4108Z6Z Transcriptional regulator E5N89_02705 ENOG4105G5H Membrane E5N89_02710 ENOG4107QX8 SPFH domain, Band 7 family protein E5N89_02715 ENOG41083J0 (ABC) transporter E5N89_02720 ENOG4105C4B ABC transporter, permease E5N89_02725 ENOG4107QR8 Thioredoxin E5N89_02730 ENOG4105E1F short-chain dehydrogenase reductase E5N89_02735 ENOG4108UJV acyl-CoA thioesterase i E5N89_02740 ENOG4108I0Y (ABC) transporter E5N89_02745 ENOG4105CV6 ABC transporter, permease E5N89_02755 ENOG4105D01 (LipO)protein E5N89_02760 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5N89_02765 ENOG4108UMI ABC transporter, permease E5N89_02770 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) E5N89_02780 ENOG4108Z2U ureidoglycolate hydrolase E5N89_02790 ENOG41060W2 glyoxylate carboligase E5N89_02795 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E5N89_02800 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5N89_02810 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E5N89_02820 ENOG4105DTE Xanthine uracil vitamin C permease E5N89_02825 ENOG4105BZW Glycerate kinase E5N89_02830 ENOG4105S0E allantoin catabolism protein E5N89_02835 ENOG4105CE7 Amidase, hydantoinase carbamoylase family E5N89_02840 ENOG4105DG4 malate L-lactate dehydrogenase E5N89_02845 ENOG4107R1Q Membrane protein FdrA E5N89_02850 ENOG4107REC cytoplasmic protein E5N89_02855 ENOG4105G5A Protein of unknown function (DUF2877) E5N89_02860 ENOG4105C5B carbamate kinase E5N89_02865 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E5N89_02870 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E5N89_02880 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E5N89_02900 ENOG4105S2T inner membrane protein YbcI E5N89_02905 ENOG4105WQ3 Rna-binding protein E5N89_02920 ENOG4108WDE Fimbrial protein E5N89_02925 ENOG4105NJT Fimbrial protein E5N89_02930 ENOG4108AF8 Chaperone E5N89_02935 ENOG4105CW0 outer membrane usher protein E5N89_02940 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) E5N89_02945 ENOG4108ZI2 Fimbrial protein E5N89_02950 ENOG4108Q9V regulatoR E5N89_02955 ENOG4106721 fimbriae Y protein E5N89_02965 ENOG4106KCD HTH_LUXR E5N89_02975 ENOG4108KU3 Integrase E5N89_02990 ENOG4105CKK Glycosyl transferase, family 2 E5N89_02995 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E5N89_03005 ENOG4105GR3 Histidine kinase E5N89_03010 ENOG4108IJF Heavy metal efflux pump, CzcA E5N89_03015 ENOG4108K01 transcriptional regulator E5N89_03020 ENOG4107QN2 dihydrolipoyl dehydrogenase E5N89_03025 ENOG41066GK UPF0379 protein ykgI E5N89_03030 ENOG4108KBJ Inner membrane protein YkgB E5N89_03040 ENOG4105C85 amino acid E5N89_03045 ENOG4105CUY Mechanosensitive ion channel E5N89_03055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N89_03060 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E5N89_03070 ENOG4105F3R pts system mannose fructose sorbose family iid E5N89_03090 ENOG4108RCM Nitroreductase E5N89_03095 ENOG4105MSB protein, conserved in bacteria E5N89_03100 ENOG41067SE Tetr family transcriptional regulator E5N89_03105 ENOG4105HFT AraC family transcriptional regulator E5N89_03110 ENOG4105WQ6 Membrane E5N89_03115 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) E5N89_03120 ENOG4108TSE Transferase E5N89_03125 ENOG4107RNH Outer membrane receptor FepA E5N89_03130 ENOG4105E93 esterase E5N89_03135 ENOG41085A6 mbth domain-containing protein E5N89_03140 ENOG4105C0W non-ribosomal peptide synthetase E5N89_03145 ENOG4108QY5 Ferric enterobactin transport protein E5N89_03150 ENOG4105E0A ABC, transporter E5N89_03155 ENOG4105TVJ transport system, permease E5N89_03160 ENOG4105DQ5 transport system permease protein E5N89_03165 ENOG4105E8G Major facilitator Superfamily E5N89_03170 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein E5N89_03175 ENOG4105E4F Isochorismate synthase E5N89_03180 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E5N89_03185 ENOG4105WQI isochorismatase E5N89_03190 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E5N89_03195 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) E5N89_03200 ENOG4105D22 carbon starvation protein E5N89_03205 ENOG4105VCD cytoplasmic protein E5N89_03210 ENOG4107SCQ Iron-containing alcohol dehydrogenase E5N89_03215 ENOG4105CHM Aminotransferase E5N89_03220 ENOG4105GTN ParB Domain Protein Nuclease E5N89_03225 ENOG4105BZV Phosphoadenosine phosphosulfate reductase E5N89_03230 ENOG4105DQS Transcriptional regulator E5N89_03235 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E5N89_03240 ENOG4105D3R alkyl hydroperoxide reductase E5N89_03245 ENOG4108JU3 Alkyl hydroperoxide reductase E5N89_03255 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E5N89_03260 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N89_03270 ENOG4108U51 Universal stress protein E5N89_03275 ENOG4105E2A Dehydrogenase E5N89_03280 ENOG4105NXH GreA GreB family elongation factor E5N89_03285 ENOG4105KTS ribonuclease E5N89_03290 ENOG4107QPK )-transporter E5N89_03295 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5N89_03300 ENOG4105YGP holo-ACP synthase CitX E5N89_03305 ENOG4105CHY citrate lyase, alpha E5N89_03310 ENOG4105CI0 Citrate lyase E5N89_03315 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) E5N89_03320 ENOG4105DUA (citrate (pro-3S)-lyase ligase E5N89_03325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E5N89_03330 ENOG4106YYS transcriptional regulatory protein E5N89_03335 ENOG4105CEE C4-dicarboxylate transporter E5N89_03340 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) E5N89_03345 ENOG4105VEQ Cold shock protein E5N89_03355 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E5N89_03370 ENOG41064T2 transcriptional regulator, lysR family E5N89_03380 ENOG4108Z43 UPF0250 protein E5N89_03385 ENOG4105DZ1 carboxypeptidase E5N89_03390 ENOG4105K6T rare lipoprotein A E5N89_03395 ENOG4105CNI cell division protein FtsW E5N89_03400 ENOG4105CJN penicillin-binding protein E5N89_03410 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E5N89_03415 ENOG4108TGR phosphatase E5N89_03420 ENOG4107QZB decarboxylase E5N89_03425 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) E5N89_03430 ENOG4105DJF DNA polymerase III, delta' subunit E5N89_03435 ENOG4108U2H Rare lipoprotein B E5N89_03455 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E5N89_03460 ENOG4108JUB Transcriptional regulator E5N89_03465 ENOG4107PAI alpha helical protein E5N89_03475 ENOG41069CF Protein of unknown function (DUF1266) E5N89_03480 ENOG4105QFC Hsc56 co-chaperone of HscC E5N89_03485 ENOG41069CF Protein of unknown function (DUF1266) E5N89_03490 ENOG4105QFC Hsc56 co-chaperone of HscC E5N89_03495 ENOG4105F7F Chaperone E5N89_03505 ENOG4105DU0 nucleoside hydrolase E5N89_03510 ENOG4105CDA abc transporter atp-binding protein E5N89_03515 ENOG4105DRP amino acid AbC transporter E5N89_03520 ENOG4105EAD ABC transporter E5N89_03525 ENOG4107RP9 extracellular solute-binding protein, family 3 E5N89_03530 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E5N89_03535 ENOG4108JU5 Magnesium and cobalt efflux protein E5N89_03540 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) E5N89_03545 ENOG4105C9A Phoh family E5N89_03555 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E5N89_03600 ENOG4105CAQ asparagine synthetase E5N89_03605 ENOG4105D4U had-superfamily hydrolase, subfamily iia E5N89_03610 ENOG4105E2R ROK family E5N89_03615 ENOG4105CE4 GlcNAc 6-P deacetylase E5N89_03625 ENOG4105CI1 PTS System E5N89_03635 ENOG4105J5J Outer membrane porin E5N89_03640 ENOG4105GX6 (LipO)protein E5N89_03645 ENOG4105CSH Transporter E5N89_03650 ENOG41079YP Citrate utilization protein b E5N89_03655 ENOG4107EFR Flavocytochrome c E5N89_03660 ENOG4106P55 Transcriptional regulator E5N89_03665 ENOG41090R7 Ferric uptake E5N89_03670 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) E5N89_03675 ENOG4105NNH LexA regulated protein E5N89_03680 ENOG4105EV9 Alpha Beta Hydrolase E5N89_03685 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) E5N89_03690 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 E5N89_03700 ENOG4105D5Q Arginine ornithine antiporter E5N89_03705 ENOG4105CXN decarboxylase E5N89_03715 ENOG4105EEX Two component transcriptional regulator (Winged helix family E5N89_03720 ENOG4105C08 Histidine kinase E5N89_03730 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E5N89_03745 ENOG4105XIQ Protein of unknown function (DUF2517) E5N89_03750 ENOG4105CVP deoxyribo-dipyrimidine photolyase E5N89_03760 ENOG4107QNR UPF0135 protein E5N89_03765 ENOG4105P4J Allophanate hydrolase, subunit 1 E5N89_03770 ENOG4107R7A Allophanate hydrolase subunit 2 E5N89_03775 ENOG4105E7W lamb ycsf family protein E5N89_03785 ENOG4108W9T type 1 fimbriae regulatory protein E5N89_03825 ENOG410602S Transferase E5N89_03850 ENOG4108KK1 membrane protein AbrB duplication E5N89_03855 ENOG4105BZN citrate synthase E5N89_03860 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E5N89_03865 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E5N89_03870 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E5N89_03875 ENOG4105E33 succinate dehydrogenase E5N89_03880 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E5N89_03885 ENOG4105C7S Dehydrogenase E5N89_03895 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E5N89_03900 ENOG4105C4M (Ubiquinol oxidase) subunit I E5N89_03905 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5N89_03915 ENOG4105KJB cyd operon protein YbgE E5N89_03920 ENOG4107YD3 Thioesterase E5N89_03925 ENOG4105E02 MotA TolQ exbB proton channel E5N89_03930 ENOG4105M8F Biopolymer transport protein exbD tolR E5N89_03935 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA E5N89_03945 ENOG4105KCK Peptidoglycan-associated lipoprotein E5N89_03950 ENOG4105UFD tol-pal system protein YbgF E5N89_03995 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E5N89_04000 ENOG4105PGM cation diffusion facilitator family transporter E5N89_04005 ENOG4105JND homeobox protein E5N89_04010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5N89_04015 ENOG4107GFK fumarate E5N89_04020 ENOG4106DSS Tartrate dehydratase subunit alpha E5N89_04025 ENOG4105C5Q Transcriptional regulator E5N89_04035 ENOG4107QWE )-transporter E5N89_04040 ENOG4106AFN Lyase and sodium transporter (By similarity) E5N89_04045 ENOG4107QSA Oxaloacetate decarboxylase E5N89_04050 ENOG4105D9Q decarboxylase (Beta subunit) E5N89_04055 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5N89_04060 ENOG4105EHG Permease protein E5N89_04065 ENOG4105E0A ABC, transporter E5N89_04075 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E5N89_04085 ENOG4105F0Z galactose-1-phosphate uridylyltransferase E5N89_04090 ENOG4105CMR udp-glucose 4-epimerase E5N89_04100 ENOG4105DKW ABC transporter E5N89_04105 ENOG4105F4R Transcriptional regulator mode E5N89_04110 ENOG410680R Protein of unknown function (DUF2592) E5N89_04115 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E5N89_04120 ENOG4105E0C molybdate abc transporter E5N89_04130 ENOG4108K4B hydrolase E5N89_04140 ENOG4105NBR Pectinesterase E5N89_04145 ENOG4105CI2 imidazolone-5-propionate hydrolase E5N89_04165 ENOG4105C84 Histidine ammonia-lyase E5N89_04170 ENOG4108V1U phospholipid-binding protein E5N89_04175 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E5N89_04185 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E5N89_04190 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E5N89_04195 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E5N89_04220 ENOG4105CHW UPF0052 protein E5N89_04230 ENOG4108RIR Molybdenum cofactor biosynthesis protein E5N89_04240 ENOG4105M00 molybdopterin converting factor, subunit 1 E5N89_04245 ENOG4108ZAF Molybdopterin E5N89_04250 ENOG4105HFZ Membrane E5N89_04255 ENOG4108RS6 transposase E5N89_04280 ENOG4107UXM Membrane E5N89_04285 ENOG4105DZQ phospholipase D Transphosphatidylase E5N89_04290 ENOG4105X23 Endonuclease Exonuclease phosphatase E5N89_04295 ENOG4105I9U inner membrane protein ybhQ E5N89_04300 ENOG4107QWP ABC-2 type transporter E5N89_04305 ENOG4107QWP ABC-2 type transporter E5N89_04310 ENOG4105CJ1 ABC, transporter E5N89_04320 ENOG4107MVR Transcriptional regulator E5N89_04325 ENOG4105C1J atp-dependent rna helicase E5N89_04330 ENOG4105DVT helicase E5N89_04335 ENOG4108MTB glycosyl transferase family E5N89_04340 ENOG4105VR4 UPF0379 protein ybiJ E5N89_04345 ENOG4105KSC Transcriptional regulator, TraR DksA family E5N89_04355 ENOG4105D8X mechanosensitive ion channel E5N89_04360 ENOG4105CDA abc transporter atp-binding protein E5N89_04365 ENOG4105E5Q amino acid AbC transporter E5N89_04370 ENOG4107R0W ABC transporter E5N89_04385 ENOG4108T1M outer membrane protein x E5N89_04390 ENOG4108I6E Sulfatase E5N89_04400 ENOG4105KST dependent repressor E5N89_04405 ENOG4105F4P )-transporter E5N89_04410 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N89_04415 ENOG4105C5H ABC transporter E5N89_04430 ENOG41072TH Protein of unknown function (DUF1479) E5N89_04435 ENOG4108HCJ Hydrolase E5N89_04440 ENOG4105C6N Formate acetyltransferase E5N89_04445 ENOG4105F1A Pyruvate formate-lyase E5N89_04450 ENOG4105D06 uba thif-type nad fad binding protein E5N89_04455 ENOG4105CVM Molybdenum cofactor synthesis domain protein E5N89_04460 ENOG4105D44 asparaginase E5N89_04465 ENOG4108JQ6 ABC transporter E5N89_04470 ENOG4105DEF Extracellular solute-binding protein, family 5 E5N89_04475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N89_04490 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway E5N89_04495 ENOG4105CI0 Citrate lyase E5N89_04500 ENOG4105BZJ Electron transfer flavoprotein E5N89_04505 ENOG4105C10 Electron transfer flavoprotein E5N89_04515 ENOG4105C1G acyl-Coa dehydrogenase E5N89_04525 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5N89_04530 ENOG4108KB2 LysR family Transcriptional regulator E5N89_04535 ENOG4105CY2 Citrate transporter E5N89_04540 ENOG4105D8V Glucose sorbosone dehydrogenase E5N89_04545 ENOG4108TGY Glutathione S-transferase E5N89_04550 ENOG4105DZ1 carboxypeptidase E5N89_04555 ENOG4107FB0 transcriptional regulator DeoR family E5N89_04560 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E5N89_04565 ENOG4107QF7 multi-drug E5N89_04570 ENOG4108HCJ Hydrolase E5N89_04575 ENOG4106UW1 Major Facilitator superfamily E5N89_04580 ENOG4108RFG Tetr family transcriptional regulator E5N89_04595 ENOG4105GWF inner membrane protein YbjM E5N89_04600 ENOG41090BQ Glutaredoxin E5N89_04605 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress E5N89_04610 ENOG4108DBC nitroreductase E5N89_04620 ENOG4108RMJ sensory transduction regulator E5N89_04625 ENOG4107RUE extracellular solute-binding protein family 1 E5N89_04630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E5N89_04635 ENOG4105F38 ABC transporter, permease E5N89_04640 ENOG4105D38 putrescine abc transporter E5N89_04645 ENOG4105RBQ inner membrane protein ybjO E5N89_04650 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) E5N89_04670 ENOG4106TNF Periplasmic binding protein E5N89_04675 ENOG4105DMR ABC, transporter E5N89_04680 ENOG4105GBT ABC transporter E5N89_04685 ENOG4106PMH Extracellular solute-binding protein family 3 E5N89_04690 ENOG4105E5Z arginine transporter ATP-binding subunit E5N89_04695 ENOG41064MM (LipO)protein E5N89_04705 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E5N89_04710 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase E5N89_04715 ENOG4105CGD Nad-dependent epimerase dehydratase E5N89_04720 ENOG4105C5W Aldolase E5N89_04725 ENOG4105C7K acetolactate synthase E5N89_04730 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E5N89_04735 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) E5N89_04740 ENOG4105DWU Membrane E5N89_04745 ENOG4105CPB ATP-dependent endonuclease of the OLD family E5N89_04750 ENOG4108MJ5 VirK protein E5N89_04755 ENOG4105DJY efflux transporter, rnd family, mfp subunit E5N89_04760 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E5N89_04765 ENOG4105VEQ Cold shock protein E5N89_04775 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5N89_04780 ENOG4108RS6 transposase E5N89_04800 ENOG4105CHJ isochorismatase hydrolase E5N89_04805 ENOG4105EUB pirin domain protein E5N89_04810 ENOG4105HEI LysR family (Transcriptional regulator E5N89_04815 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E5N89_04830 ENOG4108JJ8 (ABC) transporter E5N89_04835 ENOG4108JJ9 ABC, transporter E5N89_04840 ENOG4105C3M thioredoxin reductase E5N89_04845 ENOG4105EW9 transcriptional regulator AsnC family E5N89_04850 ENOG4105CNU cell division protein FtsK E5N89_04860 ENOG4105D1H recombination factor protein RarA E5N89_04870 ENOG4107QY8 reductase E5N89_04875 ENOG4105QAX Iron-sulfur E5N89_04880 ENOG4107KGK dmso reductase anchor subunit E5N89_04890 ENOG4105E5D amino acid E5N89_04895 ENOG4105F1A Pyruvate formate-lyase E5N89_04905 ENOG4105GUS E5N89_04910 ENOG4105C6N Formate acetyltransferase E5N89_04915 ENOG4105TMB Formate nitrite transporter E5N89_04920 ENOG4105DDY UPF0142 protein ycaO E5N89_04925 ENOG4107VMU Membrane E5N89_04935 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E5N89_04940 ENOG4108K0D peptidase, M48 E5N89_04945 ENOG4105CAT Cytidine monophosphate kinase E5N89_04950 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E5N89_04955 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E5N89_04960 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E5N89_04975 ENOG4105T0Z Conserved Protein E5N89_04995 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups E5N89_05000 ENOG4107S90 membrAne E5N89_05005 ENOG4106371 Methyltransferase E5N89_05015 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) E5N89_05020 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) E5N89_05025 ENOG4105DIT ErfK YbiS YcfS YnhG family protein E5N89_05030 ENOG4105EAQ (twin-arginine translocation) pathway signal E5N89_05035 ENOG4105C5X domain protein E5N89_05040 ENOG4105CGF Aromatic amino acid aminotransferase E5N89_05045 ENOG4105FCK Membrane E5N89_05050 ENOG4105C5S asparaginyl-tRNA synthetase E5N89_05065 ENOG4107RCH Diaminopropionate ammonia-lyase E5N89_05075 ENOG4107RH7 Nicotinate phosphoribosyltransferase E5N89_05080 ENOG4107R08 Integrase E5N89_05100 ENOG41076J9 exonuclease VIII E5N89_05135 ENOG4105JBR DNA replication protein E5N89_05235 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E5N89_05260 ENOG4108T1M outer membrane protein x E5N89_05295 ENOG4108X9F tail fiber protein E5N89_05300 ENOG4105UZW Tail fiber assembly protein E5N89_05310 ENOG4106EE1 E5N89_05320 ENOG4108RAV Conserved protein E5N89_05335 ENOG4105Y50 Virulence Protein E5N89_05340 ENOG4105CD8 aminopeptidase N E5N89_05350 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) E5N89_05355 ENOG4105QVC MOSC domain-containing protein E5N89_05365 ENOG4105C5H ABC transporter E5N89_05370 ENOG4105F1S paraquat-inducible protein a E5N89_05375 ENOG4105DY2 Paraquat-inducible protein b E5N89_05380 ENOG4108Q2G (LipO)protein E5N89_05385 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) E5N89_05395 ENOG4105DAN ATP-dependent protease E5N89_05405 ENOG4105UYK outer membrane protein a E5N89_05415 ENOG4108RZ1 DNA transformation protein E5N89_05420 ENOG4105EM2 membrane E5N89_05425 ENOG410901E Membrane E5N89_05430 ENOG41088T4 Helicase IV E5N89_05445 ENOG4105K4P CoA-binding domain protein E5N89_05460 ENOG4108V1U phospholipid-binding protein E5N89_05470 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E5N89_05480 ENOG4108MN8 Membrane E5N89_05495 ENOG41084BJ Pentapeptide repeat protein E5N89_05510 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell E5N89_05515 ENOG4106YSC E5N89_05530 ENOG4107ZY3 Histidine kinase E5N89_05535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5N89_05540 ENOG4105VT2 5-hydroxyisourate hydrolase E5N89_05545 ENOG4107UWN reductase E5N89_05550 ENOG4105EFA 4-hydroxyphenylacetate E5N89_05555 ENOG4108V8F Transcriptional regulator, MarR family E5N89_05565 ENOG4105C26 Dehydrogenase E5N89_05570 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase E5N89_05585 ENOG4105CNV Aldolase E5N89_05630 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5N89_05635 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E5N89_05640 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E5N89_05645 ENOG4105D6F Phosphatase E5N89_05650 ENOG4105XH3 E5N89_05660 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 E5N89_05665 ENOG4108R86 Transcriptional regulator E5N89_05680 ENOG4105CK7 Sodium proline symporter E5N89_05685 ENOG4105D5M phosphate starvation-inducible protein E5N89_05690 ENOG4105QEK Transcriptional regulator E5N89_05695 ENOG4107RJ1 sodium solute E5N89_05700 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E5N89_05705 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) E5N89_05710 ENOG4108QGT oligogalacturonate-specific porin E5N89_05715 ENOG4105JHE Major Facilitator Superfamily E5N89_05720 ENOG4107RJ5 oxidoreductase E5N89_05755 ENOG4107XHZ cytoplasmic chaperone TorD family protein E5N89_05760 ENOG4108UQ5 membrane protein YcdZ E5N89_05765 ENOG4105P8Q Curli production assembly transport component CsgG E5N89_05770 ENOG4108WYR Curli production assembly transport component, CsgF E5N89_05775 ENOG4108XDW curli assembly protein CsgE E5N89_05780 ENOG41086KC Transcriptional regulator E5N89_05805 ENOG4108UVJ appr-1-p processing domain protein E5N89_05810 ENOG4107RZC phospholipase d E5N89_05815 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) E5N89_05830 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) E5N89_05835 ENOG4105NAC (LipO)protein E5N89_05840 ENOG4108W47 Acidic protein msyB E5N89_05845 ENOG4105C6X Major Facilitator E5N89_05850 ENOG4105D1S lipid A biosynthesis E5N89_05855 ENOG4105C72 UPF0176 protein E5N89_05860 ENOG4108YYC ycei family E5N89_05865 ENOG4105DS1 cytochrome b561 E5N89_05870 ENOG4106974 biofilm formation E5N89_05875 ENOG4105F76 Sarcosine oxidase E5N89_05880 ENOG4105PVA Biofilm formation regulatory protein BssS E5N89_05885 ENOG4105MEA DNA damage-inducible protein i E5N89_05890 ENOG4105EKE dihydroorotase E5N89_05895 ENOG4105F3T (LipO)protein E5N89_05900 ENOG4105E9S glutaredoxin 2 E5N89_05910 ENOG4105D9U N-acetyltransferase E5N89_05920 ENOG4105EP9 oxidoreductase E5N89_05925 ENOG4105CJR Integral membrane protein (MviN E5N89_05930 ENOG4105QVD Flagella synthesis protein FlgN E5N89_05935 ENOG4105M9M anti-sigma28 factor FlgM E5N89_05940 ENOG4105CKS Flagella basal body P-ring formation protein flgA E5N89_05945 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) E5N89_05950 ENOG4108ZC9 flagellar basal-body rod protein flgc E5N89_05955 ENOG4105W00 Flagellar hook capping protein E5N89_05960 ENOG4105BZE flagellar hook protein, FlgE E5N89_05965 ENOG4108KPB Flagellar basal-body rod protein FlgF E5N89_05970 ENOG4105CGA flagellar basal-body rod protein FlgG E5N89_05985 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj E5N89_05990 ENOG4105E1Q flagellar hook-associated protein E5N89_05995 ENOG4105DTJ flagellar hook-associated protein E5N89_06000 ENOG4107QQB Ribonuclease E E5N89_06005 ENOG41071G1 Uncharacterized protein YceQ E5N89_06010 ENOG4105EI2 Pseudouridine synthase E5N89_06025 ENOG4108UHJ MAF-like protein E5N89_06030 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E5N89_06045 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) E5N89_06050 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E5N89_06055 ENOG4105CHR reductase E5N89_06060 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E5N89_06065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E5N89_06070 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E5N89_06075 ENOG4105HHA aminodeoxychorismate lyase E5N89_06085 ENOG4107QRG dna polymerase iii E5N89_06090 ENOG4105F8V Hydrolase, tatD family E5N89_06095 ENOG4105CI1 PTS System E5N89_06100 ENOG4105CNM Receptor E5N89_06105 ENOG4105K59 histidine triad (HIT) protein E5N89_06110 ENOG41090DQ Lipoprotein E5N89_06115 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) E5N89_06120 ENOG4108RUM thiamine kinase E5N89_06135 ENOG4105CEP NADH dehydrogenase E5N89_06140 ENOG4107MBR 17 kDa surface antigen E5N89_06145 ENOG4108IND Tetr family transcriptional regulator E5N89_06150 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction E5N89_06155 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N89_06160 ENOG4108JA2 transcriptioN-repair coupling factor E5N89_06165 ENOG4105D60 lipoprotein releasing system transmembrane protein E5N89_06175 ENOG4105D60 lipoprotein releasing system transmembrane protein E5N89_06185 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E5N89_06190 ENOG4107RUE extracellular solute-binding protein family 1 E5N89_06195 ENOG4105D38 putrescine abc transporter E5N89_06205 ENOG4105F38 ABC transporter, permease E5N89_06225 ENOG4105EZE Cupin 4 family protein E5N89_06240 ENOG4107QTF adenylosuccinate lyase E5N89_06250 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) E5N89_06265 ENOG4108R99 pseudouridine synthase E5N89_06270 ENOG4108HMX isocitrate dehydrogenase (NADP) E5N89_06290 ENOG4105Y50 Virulence Protein E5N89_06295 ENOG4106F2Y RICIN E5N89_06300 ENOG41060EU Cold shock-like protein E5N89_06315 ENOG4105H38 Membrane E5N89_06340 ENOG4108ZNX Heat shock protein E5N89_06350 ENOG4108VKM cytochrome b561 E5N89_06365 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N89_06375 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E5N89_06380 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E5N89_06385 ENOG4105D64 Mechanosensitive ion channel E5N89_06400 ENOG4108MEK Metal-binding protein YodA E5N89_06415 ENOG4108Z6Z Transcriptional regulator E5N89_06430 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E5N89_06440 ENOG4108YS1 cytoplasmic protein E5N89_06445 ENOG4105YP6 Domain of unknown function (DUF1869) E5N89_06460 ENOG4105Y3U Transglycosylase-associated protein E5N89_06465 ENOG4106G4W E5N89_06470 ENOG4105UCG Domain of unknown function (DUF333) E5N89_06480 ENOG4105K78 MarR family Transcriptional regulator E5N89_06485 ENOG4105DJ2 Major Facilitator Superfamily E5N89_06490 ENOG4105R1U AraC Family Transcriptional Regulator E5N89_06505 ENOG4108KXH Ybak prolyl-tRNA synthetase associated E5N89_06510 ENOG4108KHP Diguanylate cyclase E5N89_06525 ENOG4105CYN Serine protein kinase E5N89_06530 ENOG4105GNX MltA-interacting MipA family protein E5N89_06535 ENOG4105C4X radical SAM domain protein E5N89_06540 ENOG4105CV8 reductase E5N89_06545 ENOG4105DSB aldose 1-epimerase E5N89_06550 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E5N89_06560 ENOG4105VUT cytoplasmic protein E5N89_06565 ENOG4108RWI nicotinamidase E5N89_06570 ENOG4105HDK L-asparaginase E5N89_06575 ENOG4105D07 Signal peptide peptidase, SppA E5N89_06580 ENOG41069NU Nitroreductase E5N89_06585 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E5N89_06590 ENOG4108IYH Dna topoisomerase E5N89_06595 ENOG4105D82 Glutamate dehydrogenase E5N89_06600 ENOG4105MTM Protein of unknown function (DUF1496) E5N89_06605 ENOG4105M6F mutator MutT protein E5N89_06610 ENOG4105CGK Exodeoxyribonuclease III E5N89_06615 ENOG4105C8Y Acetylornithine aminotransferase E5N89_06625 ENOG4105C26 Dehydrogenase E5N89_06635 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) E5N89_06640 ENOG4108SPG Periplasmic Protein E5N89_06645 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) E5N89_06655 ENOG4105KKI DNA-binding transcriptional activator OsmE E5N89_06665 ENOG4105VZJ PTS System E5N89_06670 ENOG4105CK1 PTS System E5N89_06675 ENOG4105VCP PTS System E5N89_06680 ENOG4105EZV Transcriptional regulator E5N89_06685 ENOG4105F8D glycoside hydrolase family 4 E5N89_06690 ENOG410901P UPF0249 protein E5N89_06695 ENOG4105CH6 catalase E5N89_06705 ENOG4108ETY sodium dicarboxylate symporter E5N89_06710 ENOG4107K5X Membrane-bound metal-dependent hydrolase E5N89_06715 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E5N89_06720 ENOG4107PN8 YfeABCD locus regulator E5N89_06725 ENOG4105FGM Fructosamine kinase E5N89_06730 ENOG4105P10 Uncharacterized protein ydiZ E5N89_06735 ENOG4105DE4 1-phosphofructokinase E5N89_06740 ENOG4108NE3 Salt-induced outer membrane protein E5N89_06765 ENOG4105K25 O-Antigen polymerase E5N89_06780 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E5N89_06785 ENOG41082NX 50s ribosomal protein l35 E5N89_06790 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) E5N89_06805 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E5N89_06810 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E5N89_06820 ENOG4108V06 Glutathione peroxidase E5N89_06830 ENOG4108QBX (LipO)protein E5N89_06840 ENOG4105CNG UPF0061 protein E5N89_06845 ENOG4106EDX Hemin uptake protein E5N89_06850 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5N89_06860 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E5N89_06865 ENOG4105CEY Amp-dependent synthetase and ligase E5N89_06870 ENOG41090P5 ferredoxin-like protein E5N89_06875 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5N89_06880 ENOG4105C10 Electron transfer flavoprotein E5N89_06885 ENOG4105CV7 Electron transfer flavoprotein E5N89_06890 ENOG4105W4W Transcriptional regulator E5N89_06895 ENOG4105C1G acyl-Coa dehydrogenase E5N89_06900 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E5N89_06905 ENOG4105FF2 Type I DHQase E5N89_06910 ENOG4105E2X shikimate dehydrogenase E5N89_06915 ENOG4105EMV Major Facilitator E5N89_06920 ENOG4105EMV Major Facilitator E5N89_06925 ENOG4105SUA Ydil protein E5N89_06935 ENOG4105IPI Membrane E5N89_06940 ENOG4105CQB FAD linked oxidase domain protein E5N89_06945 ENOG4105KA0 thioesterase Superfamily protein E5N89_06950 ENOG410671Z uncharacterized protein ydiH E5N89_06955 ENOG4108ETY sodium dicarboxylate symporter E5N89_06960 ENOG4108Z4V iron-sulfur cluster assembly E5N89_06965 ENOG4105DIW FeS assembly protein SUFB E5N89_06970 ENOG4105C3K feS assembly ATPase SufC E5N89_06975 ENOG4105JRK feS assembly protein SufD E5N89_06990 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N89_07005 ENOG4105CA9 Pyruvate kinase E5N89_07010 ENOG4105CUB amino acid E5N89_07015 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) E5N89_07025 ENOG4108RVA ribokinase E5N89_07030 ENOG4105DB1 molybdopterin oxidoreductase E5N89_07035 ENOG4106WHD Tetrathionate reductase E5N89_07040 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N89_07045 ENOG4106AFQ Histidine kinase E5N89_07050 ENOG4108ZXC Two component transcriptional regulator, luxr family E5N89_07055 ENOG4105RFR Protein of unknown function (DUF2767) E5N89_07060 ENOG4107SEY Conserved Protein E5N89_07065 ENOG4108XDN Transcriptional regulator E5N89_07075 ENOG4105BZU Histidine kinase E5N89_07105 ENOG4105ZQI secreted protein E5N89_07115 ENOG4108SZ7 secretion system effector E5N89_07120 ENOG4106FZW pathogenicity island effector protein E5N89_07170 ENOG4106563 type III secretion system apparatus protein E5N89_07175 ENOG4105UQF type iii secretion E5N89_07180 ENOG4106H1D secretion system apparatus protein E5N89_07190 ENOG4108JIR Flagellum-specific ATP synthase E5N89_07205 ENOG41063Q7 Type III secretion system protein E5N89_07210 ENOG4108HHI Type III secretion system protein E5N89_07215 ENOG41083GP type iii secretion E5N89_07220 ENOG4108TN6 type iii secretion E5N89_07225 ENOG4108IUF type iii secretion E5N89_07245 ENOG4108R6K riboflavin synthase, subunit alpha E5N89_07250 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E5N89_07255 ENOG4105CZQ inner membrane transport protein YdhC E5N89_07260 ENOG4105F52 Transcriptional regulator E5N89_07275 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5N89_07280 ENOG4105K4H Nlp p60 protein E5N89_07285 ENOG4105M2J Glutaredoxin E5N89_07300 ENOG4108UYE Lactoylglutathione lyase E5N89_07305 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5N89_07310 ENOG4108WUH Transcriptional regulator, TetR family E5N89_07315 ENOG4105XZD Fe-S protein E5N89_07320 ENOG4107RGM aldo keto reductase E5N89_07325 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5N89_07330 ENOG4105DSW Fusaric acid resistance protein E5N89_07335 ENOG4105Y49 secretion protein, HlyD family E5N89_07350 ENOG4108XTF Outer Membrane Lipoprotein E5N89_07360 ENOG410642K Lysozyme inhibitor E5N89_07380 ENOG4108K3A Glutathione S-transferase E5N89_07385 ENOG4105DUX Transporter E5N89_07390 ENOG4105CSM endonuclease III E5N89_07400 ENOG4108UQQ Electron transport complex E5N89_07410 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E5N89_07425 ENOG4105M9B inner membrane protein ydgK E5N89_07435 ENOG4106C6R beta-lactam resistance protein E5N89_07440 ENOG4105D9R oxidoreductase E5N89_07445 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E5N89_07455 ENOG4105CI1 PTS System E5N89_07460 ENOG4106J39 exported protein E5N89_07465 ENOG4105EIP mannose-6-phosphate isomerase E5N89_07470 ENOG4107GFK fumarate E5N89_07475 ENOG4105C9Q fumarate hydratase class II E5N89_07485 ENOG4105JJR Histidine kinase E5N89_07490 ENOG4105CPN adenine deaminase E5N89_07495 ENOG4105FCK Membrane E5N89_07505 ENOG4107EXC regulatoR E5N89_07510 ENOG4105RA2 Membrane E5N89_07515 ENOG4105D5Q Arginine ornithine antiporter E5N89_07520 ENOG4105C5D exported protein E5N89_07525 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5N89_07530 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5N89_07535 ENOG4105DSF transport protein E5N89_07555 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap E5N89_07565 ENOG4105D94 Major Facilitator Superfamily E5N89_07570 ENOG4106NZI LysR family Transcriptional regulator E5N89_07575 ENOG4105DAG ROK family E5N89_07580 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E5N89_07585 ENOG4105CMQ Chloride channel E5N89_07590 ENOG4108IJ8 ABC transporter E5N89_07595 ENOG4105E90 ABC transporter E5N89_07600 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E5N89_07605 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component E5N89_07610 ENOG4108NEM leader-binding protein dmsD E5N89_07615 ENOG4107KGK dmso reductase anchor subunit E5N89_07620 ENOG4105QAX Iron-sulfur E5N89_07625 ENOG4105C3J Cysteine desulfurase E5N89_07630 ENOG4107QY8 reductase E5N89_07635 ENOG4105KBG Protein of unknown function (DUF1161) E5N89_07645 ENOG4108MK9 spermidine N(1)-acetyltransferase E5N89_07665 ENOG4105CPQ Dehydrogenase E5N89_07680 ENOG4105DEI Mannitol dehydrogenase E5N89_07685 ENOG41061EV selenium-binding protein YdfZ E5N89_07690 ENOG4107XBN GntR Family Transcriptional Regulator E5N89_07695 ENOG4105EMU Dehydrogenase E5N89_07700 ENOG4105DGW oligopeptidase A E5N89_07715 ENOG4108WTK competence damage-inducible protein E5N89_07720 ENOG4108YDI single-species biofilm formation on inanimate substrate E5N89_07730 ENOG4105E5W Transporter E5N89_07735 ENOG4108594 Permease of the drug metabolite transporter E5N89_07740 ENOG4106DNR multiple antibiotic resistance protein E5N89_07750 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes E5N89_07760 ENOG4105F27 Major Facilitator E5N89_07770 ENOG4105EGI Transcriptional regulator E5N89_07775 ENOG4105C26 Dehydrogenase E5N89_07785 ENOG4105M0C cytoplasmic protein E5N89_07790 ENOG4105FFC UPF0187 protein E5N89_07815 ENOG4105MVP hydrogenase-1 operon protein HyaF E5N89_07835 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E5N89_07840 ENOG4105DPX Hydrogenase, large subunit E5N89_07855 ENOG4105C6F GntR Family Transcriptional Regulator E5N89_07860 ENOG4105CPQ Dehydrogenase E5N89_07865 ENOG4108I5G Major Facilitator superfamily E5N89_07880 ENOG4107SCK Monooxygenase E5N89_07890 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E5N89_07895 ENOG4108UQ8 endoribonuclease L-psp E5N89_07945 ENOG41060NJ transcriptional regulator E5N89_07950 ENOG4105DFD Na H antiporter E5N89_07955 ENOG4105C87 Aminotransferase class I and II E5N89_07970 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E5N89_07980 ENOG4105XXV Acid-resistance protein E5N89_07985 ENOG4108Z9K Osmotically inducible protein E5N89_07990 ENOG4105TPS biofilm-dependent modulation protein E5N89_08005 ENOG4105DQ4 alcohol dehydrogenase E5N89_08010 ENOG4108MG3 formate dehydrogenase E5N89_08015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N89_08050 ENOG4107QND Nitrite extrusion protein E5N89_08055 ENOG4105CRU nitrate reductase, alpha subunit E5N89_08060 ENOG4108IUE nitrate reductase beta subunit E5N89_08065 ENOG4108NZN Respiratory nitrate reductase 2 delta chain E5N89_08070 ENOG4105D0D Nitrate reductase 2, gamma subunit E5N89_08075 ENOG4105JAB phenazine biosynthesis protein, phzf family E5N89_08080 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase E5N89_08095 ENOG4105C85 amino acid E5N89_08100 ENOG4105SUV lipoprotein YgdR E5N89_08105 ENOG4108NS2 receptor E5N89_08110 ENOG4105CHB tonB-dependent Receptor E5N89_08115 ENOG4108WYP Transcriptional regulator E5N89_08120 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E5N89_08125 ENOG4108Z7F N-acetyltransferase E5N89_08130 ENOG4108T9Y Inner membrane protein ydcZ E5N89_08135 ENOG4105R71 cytoplasmic protein E5N89_08155 ENOG410654E Membrane E5N89_08165 ENOG4105C26 Dehydrogenase E5N89_08170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E5N89_08175 ENOG4108UQS dipeptidase E5N89_08195 ENOG4105RR0 Protein of unknown function (DUF2554) E5N89_08200 ENOG4105CFP Peptidase U32 E5N89_08205 ENOG4108JCI Transcriptional regulator E5N89_08210 ENOG4105DKK Benzoate E5N89_08215 ENOG4108KKZ (LipO)protein E5N89_08220 ENOG41088CC tellurite resistance protein tehB E5N89_08225 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein E5N89_08230 ENOG4107WE3 acetyltransferase YdcK E5N89_08235 ENOG4108Z9I -acetyltransferase E5N89_08240 ENOG4105CN9 Peptidase m42 family protein E5N89_08245 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E5N89_08250 ENOG4105DT3 PTS system, galactitol-specific IIc component E5N89_08255 ENOG4106P19 photosystem i assembly btpa E5N89_08260 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E5N89_08265 ENOG4108RK0 3-epimerase E5N89_08270 ENOG4108PQ7 sgc region transcriptional regulator E5N89_08275 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) E5N89_08285 ENOG4108YYC ycei family E5N89_08290 ENOG4105DJ9 glucan biosynthesis protein E5N89_08295 ENOG4105EBR Carboxylesterase E5N89_08300 ENOG4105E32 cytoplasmic protein E5N89_08305 ENOG4105DDW LysR family Transcriptional regulator E5N89_08310 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_08335 ENOG4107ZUJ lipid metabolic process E5N89_08345 ENOG4107R0W ABC transporter E5N89_08350 ENOG4105E5Q amino acid AbC transporter E5N89_08360 ENOG4105E5Q amino acid AbC transporter E5N89_08370 ENOG4108WF3 methyltransferase E5N89_08375 ENOG4105CPW cytochrome b561 E5N89_08380 ENOG4107DB1 DUF218 domain E5N89_08385 ENOG4105CQ7 ATP-dependent helicase E5N89_08400 ENOG4105WXT Conserved Protein E5N89_08405 ENOG410689M (LipO)protein E5N89_08410 ENOG4107H52 Dicarboxylate transport E5N89_08415 ENOG4105C5I Dehydrogenase E5N89_08420 ENOG41090X5 Heat shock protein hslJ E5N89_08435 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) E5N89_08440 ENOG4108RW8 Universal stress protein F E5N89_08445 ENOG410814C multidrug resistance protein E5N89_08465 ENOG4105C1J atp-dependent rna helicase E5N89_08480 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_08485 ENOG4108DG9 Smr protein MutS2 E5N89_08490 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E5N89_08500 ENOG4105Q9Y Universal stress protein E5N89_08505 ENOG4105S5I Membrane E5N89_08510 ENOG4105D64 Mechanosensitive ion channel E5N89_08530 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E5N89_08550 ENOG4106PHM regulatory protein E5N89_08565 ENOG4108XFH Transcriptional regulator E5N89_08570 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E5N89_08575 ENOG4105CV8 reductase E5N89_08580 ENOG4105HEI LysR family (Transcriptional regulator E5N89_08590 ENOG4107QSI ABC, transporter E5N89_08595 ENOG4105KXI murein peptide amidase A E5N89_08600 ENOG4107S8C mandelate racemase muconate lactonizing E5N89_08605 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E5N89_08610 ENOG4108JU8 Transcriptional regulator E5N89_08615 ENOG4106K28 UPF0283 membrane protein E5N89_08620 ENOG4105CM6 amino acid regulated cytosolic protein E5N89_08625 ENOG4105K8Z Phage shock protein E5N89_08630 ENOG4105NNG Peripheral inner membrane phage-shock protein E5N89_08635 ENOG4105FM1 phage shock protein C E5N89_08640 ENOG4105YYT phage shock protein B E5N89_08645 ENOG41087YS Phage shock protein A E5N89_08650 ENOG4105E51 psp operon transcriptional activator E5N89_08655 ENOG4108J59 Extracellular solute-binding protein, family 5 E5N89_08660 ENOG4108I5W peptide transport system, permease protein E5N89_08665 ENOG4108EU3 peptide transport system, permease E5N89_08670 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein E5N89_08675 ENOG4108JQ2 peptide transport system atp-binding protein E5N89_08700 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E5N89_08705 ENOG4105Q4T oxidoreductase E5N89_08715 ENOG4105BZU Histidine kinase E5N89_08725 ENOG4105N2W Transcriptional regulator E5N89_08730 ENOG41061RM osmotically inducible lipoprotein E5N89_08735 ENOG4108ZJT translation initiation factor, Sui1 E5N89_08740 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) E5N89_08745 ENOG4105CFV Tetratricopeptide repeat protein E5N89_08750 ENOG4105Q4A inner membrane protein yciS E5N89_08755 ENOG4105EYK Phosphatidylglycerophosphatase B E5N89_08765 ENOG4107QM5 aconitate hydratase E5N89_08780 ENOG4107R11 Transcriptional regulator E5N89_08785 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E5N89_08790 ENOG4105RKX Protein of unknown function (DUF2498) E5N89_08795 ENOG4105ERU peptidase E5N89_08800 ENOG4105UBK short-chain dehydrogenase reductase E5N89_08805 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E5N89_08810 ENOG4105FE9 pseudouridine synthase E5N89_08815 ENOG4107RTD sua5 ycio yrdc ywlc family protein E5N89_08820 ENOG4105DB7 PHP domain protein E5N89_08830 ENOG4105CRQ synthase (Component I) E5N89_08835 ENOG4108EFP Anthranilate synthase component II E5N89_08840 ENOG4105DK0 Indole-3-glycerol phosphate synthase E5N89_08850 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) E5N89_08860 ENOG4108Z9Z response to DNA damage stimulus E5N89_08865 ENOG4108N8X transition metal ion binding E5N89_08870 ENOG4105WEF catalase E5N89_08875 ENOG4105EIF outer membrane protein W E5N89_08880 ENOG4105PI0 Ferredoxin E5N89_08895 ENOG4105NAU thioesterase Superfamily protein E5N89_08900 ENOG410822N TonB family E5N89_08905 ENOG4105K9H YciI-like protein E5N89_08925 ENOG4105EYW Ion transport protein E5N89_08930 ENOG4108JQ7 (ABC) transporter E5N89_08935 ENOG4105C3U ABC transporter E5N89_08940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E5N89_08945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N89_08950 ENOG4107QSI ABC, transporter E5N89_08955 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein E5N89_08960 ENOG4108EKI Dehydrogenase E5N89_08975 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E5N89_08980 ENOG4105I93 response regulator E5N89_08985 ENOG4105D78 K07001 NTE family protein E5N89_08990 ENOG4105K5B UPF0225 protein E5N89_08995 ENOG4105CIY formyltetrahydrofolate deformylase E5N89_09040 ENOG41076YT nitrate reductase, gamma subunit E5N89_09045 ENOG4105R3A Nitrate reductase E5N89_09050 ENOG4108IUE nitrate reductase beta subunit E5N89_09055 ENOG4105CRU nitrate reductase, alpha subunit E5N89_09060 ENOG4105DQQ Major facilitator superfamily MFS_1 E5N89_09065 ENOG4105BZU Histidine kinase E5N89_09070 ENOG4105WH1 Two component transcriptional regulator luxr family E5N89_09075 ENOG4105ID0 Putative invasin E5N89_09080 ENOG41090EX DsrE family E5N89_09085 ENOG4105WS7 Cation transport regulator E5N89_09090 ENOG4105EWV Sodium calcium exchanger membrane region E5N89_09100 ENOG41063JG Transcriptional regulator E5N89_09105 ENOG4108YY7 Invasion gene expression up-regulator SirB E5N89_09110 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E5N89_09130 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E5N89_09135 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E5N89_09140 ENOG4105CHH sulfate transporter E5N89_09145 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria E5N89_09155 ENOG4105C3G gtp-binding protein E5N89_09165 ENOG4105E3S small subunit E5N89_09175 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E5N89_09180 ENOG4108USZ hydrogenase E5N89_09185 ENOG4108VXY Hydrogenase-1 operon protein HyaE E5N89_09190 ENOG4105MVP hydrogenase-1 operon protein HyaF E5N89_09195 ENOG4105C4M (Ubiquinol oxidase) subunit I E5N89_09200 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5N89_09210 ENOG4105D82 Glutamate dehydrogenase E5N89_09225 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) E5N89_09235 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A E5N89_09245 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E5N89_09255 ENOG4105ED1 spovr family E5N89_09280 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation E5N89_09295 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E5N89_09310 ENOG4107QMS site-determining protein E5N89_09320 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) E5N89_09325 ENOG4105CEY Amp-dependent synthetase and ligase E5N89_09330 ENOG4105Y4Z Outer Membrane Lipoprotein E5N89_09335 ENOG41072GX Peptidase M22 Glycoprotease E5N89_09340 ENOG4105DVT helicase E5N89_09345 ENOG4105M4H endoribonuclease L-psp E5N89_09355 ENOG4105CRQ synthase (Component I) E5N89_09365 ENOG4105EJQ L-serine dehydratase E5N89_09370 ENOG4107XTP (EAL) domain protein E5N89_09375 ENOG4105EE5 Membrane protein terC E5N89_09380 ENOG4108EQA pts system E5N89_09385 ENOG4105ETZ PTS System E5N89_09390 ENOG4105F3R pts system mannose fructose sorbose family iid E5N89_09405 ENOG4105DHI Methyltransferase E5N89_09410 ENOG4105CJN penicillin-binding protein E5N89_09415 ENOG4105VEQ Cold shock protein E5N89_09420 ENOG410610J Protein of unknown function (DUF2627) E5N89_09425 ENOG4105Q3Y exported protein E5N89_09440 ENOG4105J4Q Transcriptional regulator E5N89_09445 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N89_09455 ENOG4105CN1 protease E5N89_09465 ENOG4108ZGC gaf domain protein E5N89_09470 ENOG4105H2K paraquat-inducible protein a E5N89_09475 ENOG4105DY2 Paraquat-inducible protein b E5N89_09480 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E5N89_09485 ENOG4105WT8 Protein of unknown function (DUF1480) E5N89_09490 ENOG4105UVW uncharacterized protein yebW E5N89_09495 ENOG4108R1E Serine threonine protein phosphatase 1 E5N89_09505 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling E5N89_09510 ENOG41064WM Uncharacterized protein YcgX E5N89_09520 ENOG4105VEV -acetyltransferase E5N89_09555 ENOG4105DWP Membrane E5N89_09595 ENOG4105UZW Tail fiber assembly protein E5N89_09615 ENOG4108YV9 Protein of unknown function (DUF2514) E5N89_09625 ENOG41076J9 exonuclease VIII E5N89_09635 ENOG4105NKT exported protein E5N89_09640 ENOG4108PNC copper resistance E5N89_09645 ENOG4105FXM Copper resistance protein E5N89_09650 ENOG4105MPK DNA polymerase III subunit theta E5N89_09655 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E5N89_09660 ENOG4105UMD exodeoxyribonuclease X E5N89_09665 ENOG4105CUG Oligopeptidase b E5N89_09670 ENOG4108Q2J Inner membrane protein YebE E5N89_09675 ENOG4105RSZ secreted protein E5N89_09680 ENOG4105X2V dna damage-inducible protein E5N89_09685 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR E5N89_09690 ENOG4108UHU Aldolase E5N89_09695 ENOG4105C01 Dihydroxy-acid dehydratase E5N89_09700 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E5N89_09705 ENOG4106KNT transcriptional regulator E5N89_09710 ENOG4105CA9 Pyruvate kinase E5N89_09715 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E5N89_09720 ENOG4105DR5 peptidase E5N89_09725 ENOG4105NXV High-affinity zinc uptake system protein E5N89_09730 ENOG4105FDK ABC transporter E5N89_09735 ENOG4105FAV ABC, transporter E5N89_09755 ENOG4107S01 Repressor protein MetJ E5N89_09770 ENOG4108TIT dATP pyrophosphohydrolase E5N89_09775 ENOG4105C9M aspartyl-trna synthetase E5N89_09780 ENOG4105D3W isochorismatase E5N89_09785 ENOG41081XQ Conserved Protein E5N89_09790 ENOG4105WJG Glutathione E5N89_09800 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) E5N89_09810 ENOG4106ZCM YecM protein E5N89_09825 ENOG4105F5H Glycosyl Hydrolase Family 88 E5N89_09830 ENOG4105IRD Flagellar protein FlhE E5N89_09835 ENOG4105D7B Flagellar biosynthesis protein flha E5N89_09840 ENOG4105D00 flagellar biosynthetic protein flhB E5N89_09845 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) E5N89_09850 ENOG4108VYJ response regulator receiver protein E5N89_09860 ENOG4105BZU Histidine kinase E5N89_09865 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_09870 ENOG4108V3W Chemotaxis protein, CheW E5N89_09875 ENOG4105CBS Chea signal transduction histidine kinase E5N89_09880 ENOG4105ER2 Ompa motb domain protein E5N89_09885 ENOG4107RD7 Flagellar Motor Protein, MotA E5N89_09890 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region E5N89_09895 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) E5N89_09905 ENOG4108VA4 Universal stress protein E5N89_09915 ENOG4108K4C ec 3.1.3.12 E5N89_09930 ENOG4108UEC Ferritin-like protein E5N89_09940 ENOG4105P23 (LipO)protein E5N89_09945 ENOG41090A1 ferritin E5N89_09950 ENOG4105VVZ metal-binding protein E5N89_09955 ENOG4105E0U tyrosine-specific transport protein E5N89_09960 ENOG4106RHG Yeca family E5N89_10005 ENOG4105WH1 Two component transcriptional regulator luxr family E5N89_10015 ENOG4105XVG cytoplasmic protein E5N89_10020 ENOG4105VJY transcriptional regulator E5N89_10025 ENOG4105CDA abc transporter atp-binding protein E5N89_10030 ENOG4105E5Q amino acid AbC transporter E5N89_10035 ENOG4105K6H D-cysteine desulfhydrase E5N89_10040 ENOG4105EAB amino acid AbC transporter E5N89_10045 ENOG4108M9K flagella biosynthesis protein FliZ E5N89_10050 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5N89_10055 ENOG4108RS6 transposase E5N89_10060 ENOG4108C80 FliB family E5N89_10065 ENOG4105I03 Flagellin E5N89_10070 ENOG4105DTS flagellar hook-associated E5N89_10075 ENOG4105MQ3 flagellar protein FliS E5N89_10085 ENOG4105E5K Alpha-amylase E5N89_10090 ENOG4105JCU Inherit from NOG: (Lipo)protein E5N89_10095 ENOG41066VF YeeE YedE family protein E5N89_10100 ENOG4105KSU Redox protein E5N89_10115 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) E5N89_10120 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E5N89_10125 ENOG41090PJ Flagellar assembly protein E5N89_10130 ENOG4108JIR Flagellum-specific ATP synthase E5N89_10135 ENOG4105GSA Flagellar export protein flij E5N89_10140 ENOG4105WF4 Flagellar hook-length control protein E5N89_10145 ENOG4107ZI8 flagellar basal body-associated protein flil E5N89_10150 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E5N89_10155 ENOG4105DD5 Flagellar motor switch protein E5N89_10160 ENOG4105K0P flagellar biosynthesis protein E5N89_10165 ENOG4105CN7 Flagellar biosynthetic protein FliP E5N89_10170 ENOG4105VS8 Flagellar biosynthetic protein fliq E5N89_10175 ENOG4105D19 Role in flagellar biosynthesis (By similarity) E5N89_10180 ENOG4107TKS colanic acid capsular biosynthesis activation protein A E5N89_10190 ENOG4105YX3 cellular response to acidity E5N89_10200 ENOG4105BZU Histidine kinase E5N89_10205 ENOG4105VNZ cytoplasmic protein E5N89_10210 ENOG4105CKW Inner membrane protein yedI E5N89_10215 ENOG4105FDR Membrane E5N89_10220 ENOG41090BB DNA mismatch endonuclease (vsr) E5N89_10225 ENOG4105DVF Cytosine-specific methyltransferase E5N89_10230 ENOG4105EST Metal Dependent Phosphohydrolase E5N89_10235 ENOG4105Y0K Inner membrane protein YedR E5N89_10240 ENOG4105FCK Membrane E5N89_10255 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E5N89_10260 ENOG4105KT5 UmuD protein E5N89_10300 ENOG4105W3V DNA-binding, transcriptional regulator E5N89_10305 ENOG4105UZW Tail fiber assembly protein E5N89_10310 ENOG4105Y9F tail fiber protein E5N89_10315 ENOG4105Y0G tail protein E5N89_10320 ENOG4108T86 baseplate J family protein E5N89_10365 ENOG4105TKZ Tail Sheath E5N89_10410 ENOG4105EFC phage portal protein HK97 family E5N89_10420 ENOG4105CAR Terminase, large subunit E5N89_10450 ENOG4105NVB glycoside hydrolase, family 19 E5N89_10475 ENOG4105HGD Antitermination protein E5N89_10480 ENOG4108MXB Protein of unknown function (DUF968) E5N89_10490 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) E5N89_10495 ENOG4105DFE Dna adenine methylase E5N89_10515 ENOG4106050 phage regulatory protein, rha family E5N89_10520 ENOG4108S1U E5N89_10550 ENOG4105H40 E5N89_10555 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) E5N89_10560 ENOG4108R7K Metal Dependent Phosphohydrolase E5N89_10665 ENOG4105FYV Amp nucleosidase E5N89_10690 ENOG4105UQX Mate efflux family protein E5N89_10700 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5N89_10715 ENOG4108YZT Adenosylcobinamide kinase E5N89_10720 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E5N89_10725 ENOG4108JJB ABC transporter E5N89_10730 ENOG4108V4M Cobalt abc transporter E5N89_10740 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E5N89_10745 ENOG4105DVK Precorrin-2 c20-methyltransferase E5N89_10750 ENOG4107PPM cobalt chelatase E5N89_10755 ENOG4105QUC reductase E5N89_10760 ENOG4105E4R Precorrin-3B C17-methyltransferase E5N89_10765 ENOG4108P62 biosynthesis protein (CbiG) E5N89_10770 ENOG4105CIA precorrin-4 C(11)-methyltransferase E5N89_10775 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase E5N89_10780 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase E5N89_10790 ENOG41081F0 Precorrin-8x methylmutase E5N89_10795 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) E5N89_10800 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E5N89_10805 ENOG4107XVH Transcriptional regulator E5N89_10810 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E5N89_10815 ENOG4105KNY Microcompartments protein E5N89_10820 ENOG4105EHR propanediol utilization protein pduB E5N89_10825 ENOG4105DMB glycerol dehydratase E5N89_10830 ENOG4105YCI dehydratase medium subunit E5N89_10835 ENOG4108ZFT Dehydratase small subunit E5N89_10840 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E5N89_10850 ENOG4105KNY Microcompartments protein E5N89_10855 ENOG4105S3V Carbon dioxide concentrating mechanism protein E5N89_10860 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) E5N89_10870 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E5N89_10880 ENOG4108EKI Dehydrogenase E5N89_10885 ENOG4108EKI Dehydrogenase E5N89_10890 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E5N89_10900 ENOG4105M3W utilization protein E5N89_10905 ENOG4105KTW ethanolamine utilization protein E5N89_10910 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E5N89_10915 ENOG4105JZC GHMP kinase E5N89_10925 ENOG4105DR8 Membrane E5N89_10930 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) E5N89_10935 ENOG4105DZ1 carboxypeptidase E5N89_10940 ENOG4108NWD Cytochrome E5N89_10945 ENOG4105QAX Iron-sulfur E5N89_10950 ENOG4108J2R molybdopterin oxidoreductase E5N89_10965 ENOG4105CJB Exodeoxyribonuclease I E5N89_10970 ENOG4105CUB amino acid E5N89_10980 ENOG4105EQ1 Transcriptional regulator E5N89_10985 ENOG4108535 NAD dependent epimerase/dehydratase family E5N89_11000 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E5N89_11005 ENOG4105CIH Imidazole acetol-phosphate transaminase E5N89_11030 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E5N89_11035 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) E5N89_11040 ENOG4105C6Y Udp-glucose 6-dehydrogenase E5N89_11045 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E5N89_11050 ENOG4105D3Q Sugar transferase E5N89_11055 ENOG4106ECQ phosphomannomutase E5N89_11060 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E5N89_11065 ENOG4108KBE Glycosyl transferase, family 2 E5N89_11070 ENOG4108TJN glycosyl transferase group 1 E5N89_11075 ENOG4107YYJ Glycosyl transferase, family 2 E5N89_11080 ENOG4105FB1 Polysaccharide Biosynthesis Protein E5N89_11085 ENOG4108SMP Nad-dependent epimerase dehydratase E5N89_11090 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E5N89_11095 ENOG4105FAW cDP-glucose 4,6-dehydratase E5N89_11100 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase E5N89_11105 ENOG4107QK7 reductase E5N89_11110 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase E5N89_11115 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5N89_11120 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase E5N89_11125 ENOG4105C1B dTDP-glucose 4-6-dehydratase E5N89_11130 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E5N89_11135 ENOG4105G1A colanic acid biosynthesis protein E5N89_11140 ENOG4107T8Q Glycosyl transferase (Group 1 E5N89_11145 ENOG4105C74 pyruvyl transferase E5N89_11150 ENOG4105PSV Polysaccharide Biosynthesis Protein E5N89_11155 ENOG4105D3Q Sugar transferase E5N89_11160 ENOG4107QKV phosphomannomutase E5N89_11165 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E5N89_11170 ENOG4106CD9 glycosyl transferase group 1 E5N89_11175 ENOG4105FGF GDP-mannose mannosyl hydrolase E5N89_11180 ENOG4105C30 Nad-dependent epimerase dehydratase E5N89_11185 ENOG4105C0K Gdp-mannose 4,6-dehydratase E5N89_11190 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF E5N89_11195 ENOG4105ECJ Glycosyl Transferase E5N89_11200 ENOG4108NYJ Colanic acid E5N89_11205 ENOG4107RXY Glycosyl transferase E5N89_11210 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB E5N89_11215 ENOG41090RK glycosyl transferase E5N89_11220 ENOG4105D75 Capsular exopolysaccharide family E5N89_11225 ENOG4105KJF protein tyrosine phosphatase E5N89_11230 ENOG4105DAY polysaccharide export protein E5N89_11235 ENOG4105EE5 Membrane protein terC E5N89_11240 ENOG4108GAE asmA family E5N89_11255 ENOG4105BZU Histidine kinase E5N89_11260 ENOG4105D03 DNA-3-methyladenine glycosylase II E5N89_11265 ENOG4105R8A Heat shock protein E5N89_11275 ENOG4105ENT Efflux transporter rnd family, mfp subunit E5N89_11280 ENOG4105BZS acriflavin resistance protein E5N89_11285 ENOG4105BZS acriflavin resistance protein E5N89_11290 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N89_11295 ENOG4105EB3 Histidine kinase E5N89_11300 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5N89_11320 ENOG4105CFP Peptidase U32 E5N89_11330 ENOG41090V3 Tir chaperone protein (CesT) family E5N89_11345 ENOG4105EIE fructose-bisphosphate aldolase E5N89_11350 ENOG4105EAA nucleoside E5N89_11355 ENOG4108KD5 ADP-ribosylation crystallin J1 E5N89_11360 ENOG4108TFM Kinase, PfkB family E5N89_11365 ENOG4105FDP GntR family transcriptional regulator E5N89_11370 ENOG4105DWF phosphomethylpyrimidine kinase E5N89_11380 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly E5N89_11385 ENOG410662B Type-1 fimbrial protein E5N89_11390 ENOG4105CW0 outer membrane usher protein E5N89_11395 ENOG4108MQF Chaperone E5N89_11410 ENOG4105D1F ATP-binding protein E5N89_11420 ENOG4108YCW (LipO)protein E5N89_11430 ENOG4108W15 Protein of unknown function (DUF1456) E5N89_11435 ENOG4108NEV two component transcriptional regulator, LytTR family E5N89_11440 ENOG4108HRK Histidine kinase E5N89_11455 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component E5N89_11460 ENOG4108IJ8 ABC transporter E5N89_11465 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component E5N89_11470 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E5N89_11475 ENOG4107QK4 glycoside hydrolase, family 3 domain protein E5N89_11480 ENOG4105CXG d-lactate dehydrogenase E5N89_11485 ENOG41061WM D-Alanyl-D-Alanine E5N89_11490 ENOG41069YE inner membrane protein yohC E5N89_11495 ENOG4105KHU inner membrane protein YohD E5N89_11500 ENOG4105H9W Short-chain dehydrogenase reductase Sdr E5N89_11505 ENOG4105ETP RND efflux system, outer membrane lipoprotein E5N89_11515 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E5N89_11520 ENOG4105MSY salicylate hydroxylase E5N89_11525 ENOG4108RXX maleylacetoacetate isomerase E5N89_11555 ENOG41067MG lrgb family E5N89_11565 ENOG4107GZ4 SanA protein E5N89_11570 ENOG4105Y9N Membrane E5N89_11575 ENOG4105BZ8 glutamate synthase E5N89_11580 ENOG4107SJI Dehydrogenase E5N89_11585 ENOG4107SDZ Galactoside transport system permease protein mglC E5N89_11590 ENOG4105C2J ABC transporter E5N89_11595 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator E5N89_11600 ENOG41060NJ transcriptional regulator E5N89_11605 ENOG4105DHF Membrane E5N89_11625 ENOG4105EJQ L-serine dehydratase E5N89_11630 ENOG4105EAC phosphoserine phosphatase E5N89_11635 ENOG4105CXY transporter E5N89_11640 ENOG4105D05 Receptor E5N89_11645 ENOG4108IQI permease E5N89_11650 ENOG4105DUM transcriptional regulator, lysR family E5N89_11655 ENOG4105HMI Membrane E5N89_11665 ENOG4105DM4 PTS System E5N89_11670 ENOG4105DE4 1-phosphofructokinase E5N89_11675 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E5N89_11680 ENOG4105S8Q sugar efflux transporter E5N89_11695 ENOG4105KRS Proteinase inhibitor E5N89_11700 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E5N89_11705 ENOG4105CKI cobalamin synthesis protein E5N89_11710 ENOG41076MN Phosphoesterase, PA-phosphatase related E5N89_11715 ENOG4107TT5 NLP P60 protein E5N89_11720 ENOG4105CXC rtn protein E5N89_11725 ENOG4105E43 Extracellular solute-binding protein, family 5 E5N89_11730 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E5N89_11735 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E5N89_11740 ENOG4108JQ5 ABC transporter E5N89_11745 ENOG4105HG6 E5N89_11750 ENOG4105C2C drug resistance transporter, Bcr CflA E5N89_11755 ENOG4105I08 Pseudouridine synthase E5N89_11760 ENOG4105CFI type iii restriction protein res subunit E5N89_11785 ENOG4105E68 Sulfatase E5N89_11795 ENOG4105KT5 UmuD protein E5N89_11800 ENOG4105Y50 Virulence Protein E5N89_11810 ENOG4105EXC Acyl-transferase E5N89_11815 ENOG4105PTU response to oxidative stress E5N89_11825 ENOG4105Y9F tail fiber protein E5N89_11850 ENOG4105HRS Antitermination protein E5N89_11855 ENOG4108MXB Protein of unknown function (DUF968) E5N89_11875 ENOG4108X9F tail fiber protein E5N89_11890 ENOG4105WH1 Two component transcriptional regulator luxr family E5N89_11895 ENOG4105KWW Biogenesis protein E5N89_11900 ENOG4107QX9 Thiol disulfide interChange protein E5N89_11905 ENOG4105DA4 cytochrome c-type biogenesis protein E5N89_11910 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) E5N89_11915 ENOG4105X3C heme exporter protein E5N89_11920 ENOG41060IM Heme exporter protein E5N89_11925 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E5N89_11930 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N89_11935 ENOG4105CUW cytochrome C-TYPE protein E5N89_11940 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) E5N89_11945 ENOG4105GXZ Ferredoxin-type protein NapH E5N89_11950 ENOG4108BGM Quinol dehydrogenase periplasmic component E5N89_11960 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase E5N89_11965 ENOG4108ZNS ferredoxin-type protein NapF E5N89_11975 ENOG4105IBP Cyclic peptide transporter E5N89_11980 ENOG4105CF1 Alkylated DNA repair protein E5N89_11985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E5N89_11990 ENOG4105CJ2 (LipO)protein E5N89_11995 ENOG4105FCK Membrane E5N89_12000 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC E5N89_12005 ENOG41068CG regulatoR E5N89_12010 ENOG4105BZU Histidine kinase E5N89_12015 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N89_12020 ENOG4105CXK mandelate racemase muconate lactonizing E5N89_12040 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N89_12045 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N89_12050 ENOG4105XPH Ferredoxin E5N89_12055 ENOG4105CZM Major Facilitator E5N89_12060 ENOG4105GZI Transcriptional regulator E5N89_12065 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E5N89_12070 ENOG4105CXY transporter E5N89_12075 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A E5N89_12085 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E5N89_12090 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is E5N89_12105 ENOG4105CSP Major Facilitator Superfamily E5N89_12110 ENOG4105CXK mandelate racemase muconate lactonizing E5N89_12115 ENOG4107258 Transcriptional regulator E5N89_12125 ENOG4108UII YfaZ family E5N89_12150 ENOG4105C3I Nad-dependent epimerase dehydratase E5N89_12155 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) E5N89_12160 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) E5N89_12175 ENOG4106GZG polymyxin resistance protein B E5N89_12180 ENOG4105CEY Amp-dependent synthetase and ligase E5N89_12190 ENOG4108IPT Naphthoate synthase E5N89_12195 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) E5N89_12205 ENOG4105E4F Isochorismate synthase E5N89_12210 ENOG4105TNS Conserved Protein E5N89_12215 ENOG4107YB6 acetyltransferase, (GNAT) family E5N89_12225 ENOG4107R88 Chemotaxis protein (CheV) E5N89_12230 ENOG4105CP2 von willebrand factor, type a E5N89_12245 ENOG4105C8S subunit m E5N89_12250 ENOG4105D65 subunit l E5N89_12260 ENOG4107UFS subunit j E5N89_12275 ENOG4107R0R NADH dehydrogenase subunit g E5N89_12280 ENOG4107QIZ NADH dehydrogenase E5N89_12285 ENOG4105GKE subunit e E5N89_12310 ENOG4107NQ8 LysR family Transcriptional regulator E5N89_12315 ENOG4105CHM Aminotransferase E5N89_12330 ENOG4107QWE )-transporter E5N89_12335 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 E5N89_12350 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E5N89_12355 ENOG4105C6K Malic enzyme E5N89_12360 ENOG4105CSX c4-dicarboxylate anaerobic carrier E5N89_12365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E5N89_12370 ENOG4108HHA Transketolase E5N89_12375 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E5N89_12385 ENOG4106ETB IIa component E5N89_12390 ENOG4105K2J Transcriptional regulator E5N89_12395 ENOG4105PTV Nudix Hydrolase E5N89_12400 ENOG4108RE9 Phosphodiesterase E5N89_12405 ENOG4108SHQ Glutathione S-transferase E5N89_12410 ENOG4105CYM Glutathione S-transferase E5N89_12415 ENOG4105ECP epimerase E5N89_12420 ENOG4108JEH abc transporter atp-binding protein E5N89_12425 ENOG4106YG3 ABC transporter E5N89_12430 ENOG4105DSP amino acid AbC transporter E5N89_12435 ENOG4105E89 ABC transporter E5N89_12440 ENOG4105E89 ABC transporter E5N89_12445 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E5N89_12455 ENOG4106M28 alanine racemase domain protein E5N89_12460 ENOG4105E5D amino acid E5N89_12470 ENOG4108JUB Transcriptional regulator E5N89_12475 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E5N89_12480 ENOG4105E96 Colicin v production protein E5N89_12485 ENOG4108S3P Sporulation domain protein E5N89_12490 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E5N89_12500 ENOG4105DQR SNARE associated Golgi E5N89_12505 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) E5N89_12510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E5N89_12520 ENOG4106WZ1 flagella biosynthesis regulator E5N89_12525 ENOG4105F9N Major Facilitator Superfamily E5N89_12535 ENOG4105R8V Transcriptional regulator E5N89_12555 ENOG4108RS6 transposase E5N89_12560 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E5N89_12565 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E5N89_12570 ENOG4105MH2 YfcL protein E5N89_12575 ENOG4108BPE -transporting atpase E5N89_12580 ENOG4105EJ9 Membrane E5N89_12595 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E5N89_12605 ENOG4108BY2 phosphohistidine phosphatase E5N89_12610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E5N89_12615 ENOG4105CHU acetyl-coa acetyltransferase E5N89_12620 ENOG4105KZW UPF0381 protein E5N89_12625 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation E5N89_12630 ENOG410903C (LipO)protein E5N89_12635 ENOG4105S64 Formate nitrite transporter E5N89_12645 ENOG4108NC2 Outer membrane protease E5N89_12650 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta E5N89_12660 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC E5N89_12665 ENOG4105CXY transporter E5N89_12670 ENOG4105W9M Membrane E5N89_12675 ENOG4105D1S lipid A biosynthesis E5N89_12685 ENOG4105CHM Aminotransferase E5N89_12700 ENOG4107RA9 decarboxylase E5N89_12705 ENOG4105CPC Aldo Keto reductase E5N89_12710 ENOG4109076 Conserved Protein E5N89_12720 ENOG4105D9N nucleoside E5N89_12725 ENOG4108KMM Diguanylate cyclase E5N89_12740 ENOG4105HZG regulatoR E5N89_12745 ENOG4105GXM Putative transcription regulator (DUF1323) E5N89_12765 ENOG4105CN8 Transcriptional regulator E5N89_12775 ENOG4105EAA nucleoside E5N89_12780 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) E5N89_12785 ENOG4108NFH Sugar hydrolase E5N89_12790 ENOG4108M0I Transcriptional regulator E5N89_12795 ENOG4105DHU Bile acid E5N89_12800 ENOG4105VRT cytoplasmic protein E5N89_12805 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) E5N89_12815 ENOG4105EXN Sulfate transport protein CysZ E5N89_12820 ENOG4105C6T cysteine synthase E5N89_12825 ENOG4105KZ7 phosphocarrier protein hpr E5N89_12835 ENOG4105C5Y PTS System E5N89_12850 ENOG4105CSW GntR family transcriptional regulator E5N89_12855 ENOG41089BK Glutamine amido-transferase E5N89_12860 ENOG4105M0Y E5N89_12870 ENOG4105C6T cysteine synthase E5N89_12875 ENOG4108IJ6 ABC transporter E5N89_12880 ENOG4105ECW sulfate abc transporter E5N89_12885 ENOG4108I5D sulfate abc transporter E5N89_12890 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein E5N89_12895 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr E5N89_12900 ENOG4108RS6 transposase E5N89_12905 ENOG4105EZR dyp-type peroxidase family protein E5N89_12910 ENOG4105E7K (LipO)protein E5N89_12915 ENOG4105QZU Inner membrane protein YfeZ E5N89_12925 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E5N89_12940 ENOG4107H8F E5N89_12945 ENOG4108K3Z AraC family transcriptional regulator E5N89_12950 ENOG4108X49 Ethanolamine utilization protein EutK E5N89_12955 ENOG4106D67 ethanolamine utilization protein E5N89_12965 ENOG4105CPD ethanolamine ammonia-lyase E5N89_12970 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase E5N89_12975 ENOG4105ENY Ethanolamine utilization protein eutH E5N89_12980 ENOG4105C0A alcohol dehydrogenase E5N89_12985 ENOG4107RWI ethanolamine utilization protein eutJ E5N89_12990 ENOG4108EKI Dehydrogenase E5N89_12995 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E5N89_13000 ENOG4105KNY Microcompartments protein E5N89_13005 ENOG4108IJ2 phosphate acetyltransferase E5N89_13010 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase E5N89_13015 ENOG4105NDK ethanolamine utilization protein E5N89_13020 ENOG4106S4J ethanolamine utilization protein EutP E5N89_13025 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place E5N89_13030 ENOG4105C6K Malic enzyme E5N89_13035 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E5N89_13040 ENOG4105CV1 Transketolase (EC 2.2.1.1) E5N89_13050 ENOG4108PVD exported protein E5N89_13055 ENOG4107VIJ nudix hydrolase E5N89_13060 ENOG4107QK9 Beta-lactamase E5N89_13065 ENOG4105BZ8 glutamate synthase E5N89_13070 ENOG4105BZU Histidine kinase E5N89_13075 ENOG4105BZS acriflavin resistance protein E5N89_13085 ENOG4105KUZ arsenate reductase E5N89_13090 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) E5N89_13100 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) E5N89_13105 ENOG4105CGZ zinc metallopeptidase E5N89_13115 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5N89_13125 ENOG4105RH4 Glycine cleavage system transcriptional repressor E5N89_13130 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E5N89_13135 ENOG4105BZW Glycerate kinase E5N89_13140 ENOG4105C02 permease E5N89_13145 ENOG4105ERG peptidase m48, ste24p E5N89_13150 ENOG4105K89 arsenate reductase E5N89_13160 ENOG4105C2W permease E5N89_13175 ENOG4108V3E phosphoribosylglycinamide formyltransferase E5N89_13180 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) E5N89_13185 ENOG4105C9X ppx gppa phosphatase E5N89_13190 ENOG4105BZU Histidine kinase E5N89_13200 ENOG41062G3 Protein of unknown function (DUF2633) E5N89_13230 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E5N89_13235 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E5N89_13270 ENOG4105VPD cellular component movement E5N89_13280 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5N89_13285 ENOG4105N21 Membrane E5N89_13305 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs E5N89_13325 ENOG4105QAX Iron-sulfur E5N89_13330 ENOG4107QY8 reductase E5N89_13335 ENOG4108JQB penicillin-binding protein 1C E5N89_13340 ENOG4105DN3 alpha-2-macroglobulin domain protein E5N89_13345 ENOG4105KHC sulfurtransferase E5N89_13355 ENOG4105YYA enhanced serine sensitivity protein SseB E5N89_13365 ENOG4105WVQ Fe-S assembly protein IscX E5N89_13370 ENOG4108ZIT Ferredoxin, 2FE-2S E5N89_13375 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB E5N89_13380 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) E5N89_13390 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E5N89_13410 ENOG4105ECY inositol monophosphatase E5N89_13415 ENOG4107XM9 (LipO)protein E5N89_13420 ENOG4105D5B Sulfite reductase, subunit A E5N89_13425 ENOG4107SHJ sulfite reductase subunit b E5N89_13430 ENOG410810Y Sulfite reductase E5N89_13435 ENOG4105D7X high-affinity nickel-transporter E5N89_13445 ENOG4108MN2 Stationary phase inducible protein CsiE E5N89_13450 ENOG4105D8G Major Facilitator superfamily E5N89_13455 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) E5N89_13460 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E5N89_13465 ENOG4108M3R transcriptional activator CadC E5N89_13470 ENOG4105D5Q Arginine ornithine antiporter E5N89_13475 ENOG4105CXN decarboxylase E5N89_13480 ENOG4105DUX Transporter E5N89_13485 ENOG4108YZA Nitrogen regulatory protein pii E5N89_13490 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N89_13495 ENOG4108SKK alpha helix protein E5N89_13500 ENOG4107WP9 Histidine kinase E5N89_13505 ENOG4108ETH Formylglycinamide ribotide synthetase E5N89_13515 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E5N89_13520 ENOG4108Z6B deaminase E5N89_13525 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB E5N89_13540 ENOG4106G6Q Transcriptional regulator E5N89_13545 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E5N89_13550 ENOG4105FCD Major Facilitator E5N89_13555 ENOG4105DND Transcriptional regulator E5N89_13560 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E5N89_13570 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E5N89_13590 ENOG4105C3F Signal peptidase i E5N89_13625 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E5N89_13630 ENOG4108C33 Resolvase E5N89_13640 ENOG4105UZW Tail fiber assembly protein E5N89_13650 ENOG410685N tail fiber protein E5N89_13710 ENOG4105D7V transposase E5N89_13730 ENOG4105IM0 capsid protein E5N89_13750 ENOG4107DE1 head-to-tail joining protein E5N89_13755 ENOG4105UZW Tail fiber assembly protein E5N89_13765 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium E5N89_13770 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E5N89_13840 ENOG4105MEA DNA damage-inducible protein i E5N89_13870 ENOG4105JBR DNA replication protein E5N89_13905 ENOG41076J9 exonuclease VIII E5N89_13930 ENOG4105WMJ Positive regulator of sigma E, RseC MucC E5N89_13960 ENOG4108IYU L-aspartate oxidase E5N89_13970 ENOG4105C1J atp-dependent rna helicase E5N89_13975 ENOG41090KR LysR family transcriptional Regulator E5N89_13995 ENOG4105EIB trna rrna methyltransferase E5N89_14000 ENOG4105K63 Thioredoxin E5N89_14005 ENOG4106IUH DTW domain containing protein E5N89_14010 ENOG4105CD5 CoA-binding domain protein E5N89_14015 ENOG4105JIM Phosphatidylserine synthase E5N89_14020 ENOG4105T42 (LipO)protein E5N89_14025 ENOG4105CSH Transporter E5N89_14055 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5N89_14060 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E5N89_14065 ENOG4105C34 Pseudouridine synthase E5N89_14070 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5N89_14075 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA E5N89_14085 ENOG4105CQC Prephenate dehydratase E5N89_14095 ENOG4105EHE chorismate mutase- prephenate dehydrogenase E5N89_14100 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5N89_14105 ENOG4108WS1 E5N89_14110 ENOG4108KHX Diguanylate cyclase E5N89_14135 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E5N89_14140 ENOG4106KVJ cytochrome C assembly protein E5N89_14145 ENOG4108JU6 CBS domain protein E5N89_14165 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E5N89_14170 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5N89_14180 ENOG4108Z1B Cyclase dehydrase E5N89_14200 ENOG4105BZ1 (ABC) transporter E5N89_14215 ENOG4105DFP Integrase E5N89_14220 ENOG4105DFP Integrase E5N89_14250 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N89_14265 ENOG4105HVQ Regulatory factor of maltose metabolism E5N89_14270 ENOG410787A Pts system, glucitol sorbitol-specific E5N89_14280 ENOG4105DZY Pts system, glucitol sorbitol-specific E5N89_14295 ENOG4108VA3 3-hexulose-6-phosphate synthase E5N89_14300 ENOG41080HJ 6-phospho 3-hexuloisomerase E5N89_14310 ENOG4105CI1 PTS System E5N89_14360 ENOG4108R0M Aminoglycoside E5N89_14405 ENOG4105BZU Histidine kinase E5N89_14435 ENOG4108VSE mercuric transport protein E5N89_14440 ENOG4105W1Y Transcriptional regulator E5N89_14465 ENOG4108ZHR arsR family transcriptional regulator E5N89_14480 ENOG4105D6U Sodium Glutamate Symporter E5N89_14565 ENOG4105NIV Esterase E5N89_14570 ENOG4107RNH Outer membrane receptor FepA E5N89_14580 ENOG4105VRE Pentapeptide repeat protein E5N89_14585 ENOG4108MJ5 VirK protein E5N89_14605 ENOG4105DHQ Histidine kinase E5N89_14635 ENOG4105D5U fad dependent oxidoreductase E5N89_14640 ENOG4105C26 Dehydrogenase E5N89_14645 ENOG4108JPW Aminotransferase E5N89_14650 ENOG4105C85 amino acid E5N89_14655 ENOG4108PVQ transcriptional regulator E5N89_14660 ENOG4109066 lysm domain bon superfamily protein E5N89_14670 ENOG4105VPI YqaE family transport protein E5N89_14675 ENOG41080HT Transcriptional regulator, arsr family E5N89_14680 ENOG4108V62 Rhodanese domain protein E5N89_14690 ENOG4108X73 DNA- binding protein E5N89_14700 ENOG4108RNS Exports L-alanine (By similarity) E5N89_14705 ENOG4108WMJ Protein of unknown function (DUF2002) E5N89_14710 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) E5N89_14720 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E5N89_14730 ENOG4105WAZ (Glutaredoxin-like protein) NrdH E5N89_14740 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N89_14745 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5N89_14750 ENOG4108IJ7 Glycine betaine E5N89_14755 ENOG4108HQS Glycine betaine E5N89_14760 ENOG4105GIJ Glycine betaine E5N89_14770 ENOG4105NTK Transcriptional repressor Mpra E5N89_14775 ENOG4105CW7 secretion protein, HlyD family E5N89_14780 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N89_14800 ENOG4105W39 Membrane E5N89_14805 ENOG4107VXZ Hydrolase E5N89_14835 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) E5N89_14840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E5N89_14850 ENOG4105Y3E Modulates RecA activity (By similarity) E5N89_14860 ENOG4107TH8 cina domain protein E5N89_14870 ENOG4105CVE Lytic murein transglycosylase E5N89_14875 ENOG410787A Pts system, glucitol sorbitol-specific E5N89_14880 ENOG4105DZY Pts system, glucitol sorbitol-specific E5N89_14885 ENOG4105VI0 Pts system, glucitol sorbitol-specific E5N89_14890 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase E5N89_14895 ENOG4105J92 DNA-binding transcriptional activator GutM E5N89_14900 ENOG410804X Transcriptional regulator E5N89_14905 ENOG4105C2X Arabinose 5-phosphate isomerase E5N89_14915 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center E5N89_14920 ENOG4107QZF nitrite reductase NADPH large subunit E5N89_14925 ENOG4105C8H hydrogenase maturation protein Hypf E5N89_14930 ENOG4108RC0 Electron transport protein E5N89_14940 ENOG4108MG9 hydrogenase 3 maturation protease E5N89_14945 ENOG4105I6X formate hydrogenlyase maturation E5N89_14950 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E5N89_14955 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit E5N89_14960 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E5N89_14965 ENOG4107TDF Formate hydrogenlyase subunit 4 E5N89_14970 ENOG4107R30 NADH dehydrogenase E5N89_14975 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E5N89_14980 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA E5N89_14985 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E5N89_14990 ENOG4107RSS Hydrogenase accessory protein HypB E5N89_14995 ENOG41083WG hydrogenase assembly chaperone E5N89_15000 ENOG4105CQS hydrogenase expression formation protein HypD E5N89_15005 ENOG4105C45 hydrogenase expression formation protein (HypE) E5N89_15015 ENOG4105VXR cytoplasmic protein E5N89_15025 ENOG4105DIK (ABC) transporter E5N89_15030 ENOG4105CC5 ABC transporter E5N89_15035 ENOG4105CC5 ABC transporter E5N89_15070 ENOG4108RBT type iii secretion E5N89_15075 ENOG4106BTR E5N89_15080 ENOG4105Y7Q type iii secretion E5N89_15085 ENOG4108RC9 Type III secretion system protein E5N89_15095 ENOG4108YAB Invasion protein E5N89_15105 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear E5N89_15130 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC E5N89_15150 ENOG4108M6W surface presentation of antigens protein SpaS E5N89_15155 ENOG4108TN6 type iii secretion E5N89_15165 ENOG41075IY surface presentation of antigens protein SpaP E5N89_15170 ENOG4105T85 surface presentation of antigens protein E5N89_15175 ENOG41078G4 surface presentation of E5N89_15180 ENOG41077MC Secretory protein (Associated with virulence) E5N89_15185 ENOG4108JIR Flagellum-specific ATP synthase E5N89_15190 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone E5N89_15195 ENOG4108HR8 type iii secretion E5N89_15200 ENOG4108N8R Invasion protein E5N89_15205 ENOG4105K44 type iii secretion E5N89_15210 ENOG41090HZ type iii secretion E5N89_15255 ENOG4105MEW serine threonine protein phosphatase E5N89_15275 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N89_15280 ENOG4105JQN Transcriptional regulator E5N89_15285 ENOG4105C6Z Gluconate E5N89_15290 ENOG4105EXW epimerase dehydratase E5N89_15295 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E5N89_15305 ENOG4105G63 Type III effector Hrp-dependent E5N89_15315 ENOG4105MVE transcriptional regulator E5N89_15325 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E5N89_15330 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E5N89_15335 ENOG4105KZM cytoplasmic protein E5N89_15345 ENOG4108K5P (LipO)protein E5N89_15365 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) E5N89_15370 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) E5N89_15380 ENOG4105N0Z inner membrane protein ygbE E5N89_15390 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) E5N89_15400 ENOG4108MXK alkaline phosphatase isozyme conversion E5N89_15405 ENOG4105PWE CRISPR-associated protein cas2 E5N89_15410 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E5N89_15420 ENOG4108VWQ crispr-associated protein E5N89_15425 ENOG41060M0 Crispr-associated protein, cse4 family E5N89_15450 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) E5N89_15455 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E5N89_15460 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E5N89_15465 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase E5N89_15470 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E5N89_15475 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E5N89_15490 ENOG4105DXN mazG family E5N89_15505 ENOG4105X54 addiction module antidote protein E5N89_15510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5N89_15515 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E5N89_15520 ENOG4105BZU Histidine kinase E5N89_15525 ENOG4105BZW Glycerate kinase E5N89_15530 ENOG4105EQX glucarate dehydratase E5N89_15535 ENOG4105EQX glucarate dehydratase E5N89_15540 ENOG4105DJB Major Facilitator Superfamily E5N89_15550 ENOG4105QDK Flavodoxin E5N89_15555 ENOG4105DR9 pseudouridine synthase E5N89_15560 ENOG4105WP7 tRNA pseudouridine synthase C E5N89_15575 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) E5N89_15580 ENOG4105EWT decarboxylase family E5N89_15585 ENOG4105C44 Serine transporter E5N89_15590 ENOG4105EJQ L-serine dehydratase E5N89_15600 ENOG4105C0A alcohol dehydrogenase E5N89_15605 ENOG4107W7X Aldolase E5N89_15610 ENOG4105EDR glucose galactose transporter E5N89_15620 ENOG4105CMG Carbohydrate kinase E5N89_15625 ENOG4105NWF RbsD or FucU transport E5N89_15630 ENOG4107EDW L-fucose operon activator E5N89_15640 ENOG4105M08 Membrane E5N89_15645 ENOG4105ETT transcriptional Regulator, LysR family E5N89_15650 ENOG4105M5B (LipO)protein E5N89_15655 ENOG4105C9B Cysteine desulfurase E5N89_15660 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E5N89_15665 ENOG4105FR1 rard protein E5N89_15670 ENOG4105CUZ uba thif-type nad fad binding protein E5N89_15675 ENOG4105CA3 membrane-bound lytic murein transglycosylase E5N89_15685 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E5N89_15690 ENOG4108EKC n-acetylglutamate synthase E5N89_15695 ENOG4107QYX exodeoxyribonuclease v alpha E5N89_15700 ENOG4107QKA exodeoxyribonuclease V beta E5N89_15705 ENOG4107QXK peptidase E5N89_15710 ENOG4105DSY exodeoxyribonuclease V, gamma E5N89_15715 ENOG4105RVB Prepilin peptidase dependent protein c E5N89_15720 ENOG4105SEN Protein of unknown function (DUF2509) E5N89_15725 ENOG4105JCS prepilin peptidase dependent protein E5N89_15730 ENOG4105IPU prepilin peptidase dependent protein A E5N89_15745 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E5N89_15760 ENOG4105EE5 Membrane protein terC E5N89_15765 ENOG4105SUV lipoprotein YgdR E5N89_15770 ENOG4105CPC Aldo Keto reductase E5N89_15780 ENOG4105CEY Amp-dependent synthetase and ligase E5N89_15790 ENOG41060NJ transcriptional regulator E5N89_15795 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E5N89_15800 ENOG4105RQF LysR family Transcriptional regulator E5N89_15810 ENOG4107QNK )-transporter E5N89_15815 ENOG4105CHR reductase E5N89_15820 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) E5N89_15825 ENOG4105CHU acetyl-coa acetyltransferase E5N89_15830 ENOG4105C5Q Transcriptional regulator E5N89_15840 ENOG4108MHD transport protein E5N89_15870 ENOG4106P2F Pfam:Pili_assembly_C E5N89_15890 ENOG4108T1M outer membrane protein x E5N89_15900 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A E5N89_15905 ENOG4105VGJ Virulence-associated protein E5N89_15925 ENOG4108K5P (LipO)protein E5N89_15935 ENOG4105CRK lysyL-tRNA synthetase E5N89_15945 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E5N89_15950 ENOG4105T95 Thiol disulfide interChange protein E5N89_15955 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5N89_15960 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) E5N89_15965 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB E5N89_15975 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) E5N89_15980 ENOG4108UT2 hemolysin iii E5N89_15990 ENOG4105CS2 ec 3.2.1.21 E5N89_16020 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E5N89_16025 ENOG4105D0A hydroxylase E5N89_16030 ENOG4107RAQ aminopeptidase E5N89_16050 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E5N89_16055 ENOG4108JQ1 Dehydrogenase E5N89_16070 ENOG4105MPN Membrane E5N89_16080 ENOG4105D64 Mechanosensitive ion channel E5N89_16085 ENOG4105D2N Aldolase E5N89_16115 ENOG4108JJB ABC transporter E5N89_16120 ENOG4108JJB ABC transporter E5N89_16125 ENOG4105CV1 Transketolase (EC 2.2.1.1) E5N89_16130 ENOG4108K0D peptidase, M48 E5N89_16140 ENOG4108MXF Alpha Beta Hydrolase E5N89_16145 ENOG4108R66 Conserved Protein E5N89_16150 ENOG4105DG4 malate L-lactate dehydrogenase E5N89_16155 ENOG4105CPQ Dehydrogenase E5N89_16160 ENOG4105DEI Mannitol dehydrogenase E5N89_16170 ENOG4107YCY Transcriptional regulator E5N89_16180 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) E5N89_16200 ENOG4107QNK )-transporter E5N89_16210 ENOG4105RWS endonuclease I E5N89_16215 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E5N89_16220 ENOG4105D7Z glutathione synthase E5N89_16240 ENOG4105CZX twitching motility protein E5N89_16245 ENOG4105DFA alanine racemase domain protein E5N89_16250 ENOG4108VIA integral membrane protein E5N89_16255 ENOG4105VZ9 UPF0235 protein E5N89_16265 ENOG4105CSA Coproporphyrinogen iii oxidase E5N89_16270 ENOG4106MH3 alpha helix chain E5N89_16275 ENOG4105HDK L-asparaginase E5N89_16280 ENOG4105K33 Periplasmic Protein E5N89_16285 ENOG41090ED Protein with unknown function (DUF469) E5N89_16290 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E5N89_16295 ENOG4105CEN a g-specific adenine glycosylase E5N89_16310 ENOG4105EAA nucleoside E5N89_16315 ENOG4105CXN decarboxylase E5N89_16320 ENOG4108UQV Membrane E5N89_16330 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase E5N89_16335 ENOG4105CYC Transferase E5N89_16340 ENOG4105DJG MaoC domain protein dehydratase E5N89_16345 ENOG4105CI0 Citrate lyase E5N89_16355 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E5N89_16365 ENOG4108UAJ Transcriptional regulator E5N89_16375 ENOG4105CUB amino acid E5N89_16385 ENOG4105CJP fad dependent oxidoreductase E5N89_16390 ENOG4105C26 Dehydrogenase E5N89_16415 ENOG4105DPW Major facilitator superfamily MFS_1 E5N89_16425 ENOG4105DEI Mannitol dehydrogenase E5N89_16440 ENOG4106032 Glutathionylspermidine synthase E5N89_16445 ENOG4105CYM Glutathione S-transferase E5N89_16450 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein E5N89_16455 ENOG4105S10 periplasmic binding protein E5N89_16460 ENOG41082MF Hydrogenase assembly chaperone hypC hupF E5N89_16465 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E5N89_16470 ENOG4108WGS hydrogenase 2-specific chaperone E5N89_16475 ENOG4108USZ hydrogenase E5N89_16480 ENOG4105DPX Hydrogenase, large subunit E5N89_16485 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit E5N89_16490 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N89_16495 ENOG4105E3S small subunit E5N89_16500 ENOG410900S Protein of unknown function (DUF2623) E5N89_16505 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_16530 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E5N89_16535 ENOG4108ZZF transport protein (ExbD) E5N89_16540 ENOG4105CWK Biopolymer transport protein, ExbB E5N89_16545 ENOG4105C28 cystathionine E5N89_16550 ENOG4108K81 inner membrane protein YghB E5N89_16555 ENOG4105CF7 AraC family transcriptional regulator E5N89_16560 ENOG4108I6A alcohol dehydrogenase E5N89_16565 ENOG4105CV8 reductase E5N89_16570 ENOG4107QPK )-transporter E5N89_16590 ENOG4105CCT upf0313 protein E5N89_16595 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E5N89_16605 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E5N89_16610 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E5N89_16615 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E5N89_16620 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N89_16625 ENOG4105F4I Transcriptional regulator E5N89_16630 ENOG4105H4F exported protein E5N89_16635 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5N89_16640 ENOG4105DHQ Histidine kinase E5N89_16645 ENOG4105NF4 modulator of drug activity E5N89_16650 ENOG4105VRH Antibiotic biosynthesis monooxygenase E5N89_16655 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N89_16660 ENOG4105IPS esterase E5N89_16665 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E5N89_16670 ENOG4108SX3 cytoplasmic protein E5N89_16675 ENOG41087AY ADP-Ribose pyrophosphatase E5N89_16690 ENOG4106032 Glutathionylspermidine synthase E5N89_16695 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E5N89_16705 ENOG4108MR7 Arylsulfotransferase E5N89_16725 ENOG4105W0Z cytoplasmic protein E5N89_16735 ENOG4105PV3 Inner membrane protein yqiJ E5N89_16740 ENOG4107S78 Band 7 protein E5N89_16755 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E5N89_16760 ENOG4105I7R Adenylate cyclase E5N89_16765 ENOG4106MWK domain protein E5N89_16770 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate E5N89_16780 ENOG4107ZVW dihydroneopterin aldolase E5N89_16800 ENOG4105VCC 30S ribosomal protein S21 E5N89_16805 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E5N89_16810 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5N89_16850 ENOG4105UZW Tail fiber assembly protein E5N89_16855 ENOG4108X9F tail fiber protein E5N89_16950 ENOG4105ED4 portal protein E5N89_16965 ENOG4105VZ1 Replication Protein E5N89_16970 ENOG4105DFE Dna adenine methylase E5N89_17000 ENOG4105MEH E5N89_17015 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5N89_17025 ENOG4105Q26 Siderophore-interacting protein E5N89_17030 ENOG4105NTW Transcriptional regulator E5N89_17035 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_17040 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor E5N89_17050 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5N89_17060 ENOG4108VKG metal-dependent hydrolase E5N89_17065 ENOG4108UB4 uncharacterized protein ygjQ E5N89_17070 ENOG4105EE0 oxidoreductase E5N89_17075 ENOG4105DU1 integral membrane protein, terc E5N89_17085 ENOG4106W5V Membrane E5N89_17095 ENOG4105WAY exported protein E5N89_17100 ENOG4105NE1 Conserved Protein E5N89_17105 ENOG41090KG Inner membrane protein YqjE E5N89_17110 ENOG4105YJD E5N89_17115 ENOG4108VBZ doxx family E5N89_17120 ENOG4105CHF Glutathione S-transferase E5N89_17125 ENOG4105KAF membrAne E5N89_17130 ENOG4105CWB LysR family transcriptional Regulator E5N89_17135 ENOG4108CNN domain protein E5N89_17140 ENOG4106D80 Uncharacterized protein YhaL E5N89_17150 ENOG4105C44 Serine transporter E5N89_17155 ENOG4105EJQ L-serine dehydratase E5N89_17160 ENOG4105C6N Formate acetyltransferase E5N89_17175 ENOG4105C7B Threonine dehydratase E5N89_17180 ENOG410811B TRANSCRIPTIONal E5N89_17190 ENOG4105BZW Glycerate kinase E5N89_17195 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5N89_17205 ENOG4105CTX dehydratase E5N89_17210 ENOG4107UEK pfkb domain protein E5N89_17215 ENOG4105MVE transcriptional regulator E5N89_17220 ENOG4105D2N Aldolase E5N89_17225 ENOG4105DE4 1-phosphofructokinase E5N89_17230 ENOG4105DM4 PTS System E5N89_17235 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E5N89_17245 ENOG41082GB PTS system galactitol-specific transporter subunit IIA E5N89_17250 ENOG41090UW PTS System E5N89_17255 ENOG4105DT3 PTS system, galactitol-specific IIc component E5N89_17260 ENOG4107WTH Galactitol-1-phosphate dehydrogenase E5N89_17270 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E5N89_17290 ENOG4105W4M Transport-associated protein E5N89_17295 ENOG4105K4T epimerase E5N89_17300 ENOG4107R7Y intracellular protease Pfpi family E5N89_17315 ENOG4108YYD acetyltransferase E5N89_17320 ENOG4105XPQ lipid carrier protein E5N89_17325 ENOG4105CFP Peptidase U32 E5N89_17330 ENOG4106RZ4 Peptidase U32 E5N89_17335 ENOG4105DEN Luciferase family E5N89_17340 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E5N89_17350 ENOG4105CIC tryptophan-specific transport protein E5N89_17355 ENOG4105C1J atp-dependent rna helicase E5N89_17395 ENOG4105CHV Transcription elongation factor NusA E5N89_17435 ENOG4105EEI dihydropteroate synthase E5N89_17440 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E5N89_17445 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) E5N89_17450 ENOG4105HBR Rna-binding protein E5N89_17455 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E5N89_17460 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase E5N89_17470 ENOG4105QYV Membrane E5N89_17485 ENOG4105EAH synthase E5N89_17490 ENOG4105HVQ Regulatory factor of maltose metabolism E5N89_17500 ENOG4105VFK BolA family E5N89_17505 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane E5N89_17510 ENOG4105E3I toluene tolerance E5N89_17515 ENOG4107PE3 Mammalian cell entry related domain protein E5N89_17520 ENOG4105CY3 ABC transporter, permease E5N89_17525 ENOG4105DHJ ABC, transporter E5N89_17530 ENOG4105FEU K -dependent Na -Ca exchanger E5N89_17535 ENOG4105C2X Arabinose 5-phosphate isomerase E5N89_17540 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E5N89_17545 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) E5N89_17550 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E5N89_17555 ENOG4108IUZ ABC transporter E5N89_17560 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5N89_17565 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA E5N89_17570 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN E5N89_17580 ENOG41080Z8 PHOSPHOCARRIER protein E5N89_17585 ENOG4108NIH transferase activity, transferring phosphorus-containing groups E5N89_17595 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain E5N89_17600 ENOG4105BZU Histidine kinase E5N89_17605 ENOG4105N5T Radical SAM Protein E5N89_17610 ENOG4105CBC glutamate synthase E5N89_17615 ENOG4105BZ8 glutamate synthase E5N89_17620 ENOG4105DFS Conserved Protein E5N89_17625 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin E5N89_17630 ENOG4105DZC cytosine deaminase E5N89_17635 ENOG4108R66 Conserved Protein E5N89_17645 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E5N89_17665 ENOG4105KB2 stringent starvation protein b E5N89_17670 ENOG4107MKT Stringent starvation protein a E5N89_17695 ENOG4105D6Z AFG1 family ATPase E5N89_17700 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III E5N89_17705 ENOG4105C0H protease E5N89_17715 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5N89_17720 ENOG4105D9Q decarboxylase (Beta subunit) E5N89_17725 ENOG4107QSA Oxaloacetate decarboxylase E5N89_17735 ENOG4107GFK fumarate E5N89_17740 ENOG4106DSS Tartrate dehydratase subunit alpha E5N89_17745 ENOG4105C8P )-transporter E5N89_17755 ENOG4105FDP GntR family transcriptional regulator E5N89_17770 ENOG4105RID UPF0379 protein yhcN E5N89_17775 ENOG4105RID UPF0379 protein yhcN E5N89_17780 ENOG4105UNR (Barnase) inhibitor E5N89_17795 ENOG4105ZQC membrane protein AaeX E5N89_17800 ENOG4105CR8 Transcriptional regulator E5N89_17805 ENOG4105D1U peptidase U62 modulator of DNA gyrase E5N89_17810 ENOG4105QD6 exported protein E5N89_17815 ENOG4105C03 ribonuclease E5N89_17825 ENOG4105VQ7 Rod shape-determining protein MreD E5N89_17830 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E5N89_17835 ENOG4105DFF Rod shape-determining protein mreb E5N89_17840 ENOG41062P1 Diguanylate cyclase phosphodiesterase E5N89_17845 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family E5N89_17860 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E5N89_17865 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E5N89_17870 ENOG4105RG0 Membrane E5N89_17875 ENOG4108IA2 Sodium pantothenate symporter E5N89_17885 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5N89_17890 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) E5N89_17895 ENOG4105CEC DNA methylase N-4 N-6 E5N89_17900 ENOG41061ME transport protein E5N89_17905 ENOG4105BZU Histidine kinase E5N89_17910 ENOG4108XG4 DNA-binding transcriptional regulator E5N89_17915 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5N89_17920 ENOG4105BZS acriflavin resistance protein E5N89_17925 ENOG4105XCM membrane LIPOPROTEIN E5N89_17960 ENOG4108Z0R Transferase E5N89_17965 ENOG4105SG3 Protein of unknown function (DUF1488) E5N89_17970 ENOG4105E2X shikimate dehydrogenase E5N89_17975 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E5N89_17980 ENOG4108WI1 Dna topoisomerase E5N89_17990 ENOG4105C79 DNA protecting protein DprA E5N89_18005 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E5N89_18010 ENOG4105C1A potassium transporter peripheral membrane E5N89_18020 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system E5N89_18025 ENOG4105W1Y Transcriptional regulator E5N89_18030 ENOG4105VTS DnaJ-like, subfamily C E5N89_18040 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E5N89_18060 ENOG41067V7 50S ribosomal protein L36 E5N89_18065 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E5N89_18070 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) E5N89_18075 ENOG4105VPB 50S ribosomal protein L30 E5N89_18080 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) E5N89_18085 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) E5N89_18095 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) E5N89_18110 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E5N89_18115 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) E5N89_18125 ENOG41083MP 50s ribosomal protein l29 E5N89_18135 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) E5N89_18140 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) E5N89_18145 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E5N89_18160 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) E5N89_18175 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E5N89_18180 ENOG4108UQY Iron-storage protein E5N89_18185 ENOG4105W53 bacterioferritin-associated ferredoxin E5N89_18190 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E5N89_18200 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) E5N89_18210 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E5N89_18215 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E5N89_18225 ENOG4105WWK YheO domain protein E5N89_18235 ENOG4108V1T peptidylprolyl cis-trans isomerase E5N89_18245 ENOG4108YZY peptidylprolyl cis-trans isomerase E5N89_18250 ENOG4105VKU nucleicacid-binding protein E5N89_18265 ENOG4105C5H ABC transporter E5N89_18270 ENOG4108K70 Transcriptional regulator E5N89_18275 ENOG4105N0V mono-oxygenase ydhR E5N89_18280 ENOG4105DNZ Alpha Beta Hydrolase E5N89_18290 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) E5N89_18295 ENOG4108UKZ OsmC family E5N89_18305 ENOG410613R integral membrane protein, YccS YhfK family E5N89_18310 ENOG4105C8Y Acetylornithine aminotransferase E5N89_18315 ENOG4105DDQ anthranilate synthase E5N89_18320 ENOG4105MZU cell filamentation protein E5N89_18325 ENOG4106195 uncharacterized protein yhfG E5N89_18330 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E5N89_18340 ENOG4107QZF nitrite reductase NADPH large subunit E5N89_18345 ENOG4105WZK nitrite reductase NADPH small subunit E5N89_18350 ENOG4107V9H nitrite transporter E5N89_18355 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E5N89_18360 ENOG4107EF2 surface-exposed virulence protein E5N89_18365 ENOG4108RS6 transposase E5N89_18370 ENOG4105VYH E5N89_18375 ENOG4105C31 Tryptophanyl-tRNA synthetase E5N89_18380 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5N89_18385 ENOG4105DJV ribulose-phosphate 3-epimerase E5N89_18390 ENOG4105DFE Dna adenine methylase E5N89_18395 ENOG4105EGB membrane protein DamX E5N89_18400 ENOG4105D49 3-dehydroquinate synthase E5N89_18410 ENOG4105E4G Type IV pilus E5N89_18415 ENOG4105ITY Required for the use of extracellular DNA as a nutrient E5N89_18420 ENOG4105XPX DNA utilization protein HofO E5N89_18425 ENOG41065NF Fimbrial assembly family protein E5N89_18430 ENOG4108U1Q Pilus assembly protein E5N89_18435 ENOG4108JQC penicillin-binding protein 1A E5N89_18440 ENOG4107RK2 ADP-ribose diphosphatase NudE E5N89_18450 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E5N89_18455 ENOG4105VEJ Heat shock protein E5N89_18460 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) E5N89_18465 ENOG4108MAJ Membrane E5N89_18475 ENOG4105E0F Histidine kinase E5N89_18480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E5N89_18485 ENOG4108RRZ Transcription elongation factor GreB E5N89_18490 ENOG4105BZM domain protein E5N89_18495 ENOG4105XFK Ferrous iron transport protein A E5N89_18500 ENOG4105CE1 Ferrous iron transport protein b E5N89_18510 ENOG4105DNE Transposase E5N89_18520 ENOG4105MJ2 Competence protein E5N89_18530 ENOG4105C6Z Gluconate E5N89_18535 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) E5N89_18540 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E5N89_18545 ENOG41061ZR Transcriptional regulator E5N89_18550 ENOG4105VXN addiction module toxin, RelE StbE family E5N89_18560 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP E5N89_18565 ENOG4105E0Y RtcB Protein E5N89_18580 ENOG4105CYB regulatoR E5N89_18585 ENOG4105E98 transcriptional regulator DeoR family E5N89_18600 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E5N89_18615 ENOG4105DCT glycerol dehydrogenase E5N89_18625 ENOG4105C01 Dihydroxy-acid dehydratase E5N89_18630 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E5N89_18635 ENOG4107HP6 Transcriptional regulator E5N89_18640 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E5N89_18660 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E5N89_18665 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E5N89_18670 ENOG41076UM multiple antibiotic resistance (MarC)-related protein E5N89_18675 ENOG4105C6Z Gluconate E5N89_18680 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E5N89_18685 ENOG4105DIQ Transcriptional regulator E5N89_18690 ENOG4105C2I pirin domain protein E5N89_18695 ENOG4105D9R oxidoreductase E5N89_18700 ENOG4105WCN acetyltransferase E5N89_18705 ENOG4108RVA ribokinase E5N89_18720 ENOG41080QX K07048 phosphotriesterase-related protein E5N89_18725 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E5N89_18730 ENOG4105WC8 Conserved Protein E5N89_18735 ENOG4107T6V glycerophosphoryl diester phosphodiesterase E5N89_18740 ENOG4108IJ9 (ABC) transporter E5N89_18750 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component E5N89_18755 ENOG4105BZ7 extracellular solute-binding protein family 1 E5N89_18765 ENOG41060M8 Pfam:PhdYeFM E5N89_18770 ENOG4108IV0 ABC, transporter E5N89_18775 ENOG4105C0Z ABC transporter E5N89_18780 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E5N89_18785 ENOG4105C32 Amino acid ABC transporter (Permease) E5N89_18790 ENOG4105CP9 extracellular ligand-binding receptor E5N89_18795 ENOG4105U59 -acetyltransferase E5N89_18805 ENOG4105CP9 extracellular ligand-binding receptor E5N89_18815 ENOG4105CRP Part of the ABC transporter FtsEX involved in E5N89_18820 ENOG4105CAK Cell division ATP-binding protein ftsE E5N89_18825 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E5N89_18830 ENOG4106H78 methyltransferase E5N89_18835 ENOG4105MG3 Membrane E5N89_18845 ENOG4107FS9 Membrane E5N89_18855 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_18865 ENOG4105EX9 Membrane E5N89_18870 ENOG4108W1V Lipoprotein E5N89_18880 ENOG4105DSF transport protein E5N89_18885 ENOG4107YAK holo-(acyl carrier protein) synthase 2 E5N89_18895 ENOG4105CMI transporter E5N89_18900 ENOG4105CJ1 ABC, transporter E5N89_18905 ENOG4105D0S secretion protein (HlyD E5N89_18910 ENOG4105CBX hi0933 family E5N89_18915 ENOG4105CJ3 phosphate transporter E5N89_18925 ENOG4108M6U Universal stress protein A E5N89_18930 ENOG4105DUX Transporter E5N89_18935 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) E5N89_18940 ENOG4105DGW oligopeptidase A E5N89_18945 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E5N89_18950 ENOG4105D6S protein involved in catabolism of external DNA E5N89_18955 ENOG4105DC8 reductase E5N89_18965 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E5N89_18970 ENOG4108KPW sugar kinase E5N89_18975 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E5N89_18980 ENOG4105FDP GntR family transcriptional regulator E5N89_19000 ENOG4106S2D Transcriptional regulator E5N89_19005 ENOG4105CBN LysR family transcriptional regulator E5N89_19010 ENOG4107H3J ribonuclease E5N89_19015 ENOG4105CSH Transporter E5N89_19020 ENOG41066T0 asmA family E5N89_19025 ENOG4105CMB EAL domain-containing protein E5N89_19030 ENOG4107SS6 2-dehydro-3-deoxygluconokinase E5N89_19035 ENOG4105CS0 peptidase E5N89_19045 ENOG4105BZU Histidine kinase E5N89_19050 ENOG4105EJG cellulose synthase E5N89_19055 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) E5N89_19060 ENOG4107EEX Cellulose synthase regulator protein E5N89_19065 ENOG4107QZ7 Cellulose synthase catalytic subunit E5N89_19070 ENOG4105UTS cellulose synthase operon protein YhjQ E5N89_19075 ENOG410661M cytoplasmic protein E5N89_19085 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT E5N89_19090 ENOG4105D1V cellulose synthase operon protein YhjU E5N89_19105 ENOG4105C44 Serine transporter E5N89_19110 ENOG4108JQ7 (ABC) transporter E5N89_19115 ENOG4105C3U ABC transporter E5N89_19120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E5N89_19125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E5N89_19130 ENOG4105DEF Extracellular solute-binding protein, family 5 E5N89_19160 ENOG4105DIJ Phosphoethanolamine transferase E5N89_19165 ENOG4106UCC Fimbrial protein E5N89_19170 ENOG4105MHR Fimbrial protein E5N89_19175 ENOG4105CW0 outer membrane usher protein E5N89_19180 ENOG4108VCD Chaperone E5N89_19185 ENOG4106EAR Fimbrial protein E5N89_19190 ENOG4105EAX Putative lipase E5N89_19195 ENOG4108R3E Dna-3-methyladenine glycosylase i E5N89_19200 ENOG4105HNP -acetyltransferase E5N89_19205 ENOG4107QY8 reductase E5N89_19210 ENOG4108ZG0 Ompa motb domain protein E5N89_19220 ENOG4106JH6 (LipO)protein E5N89_19225 ENOG4105MVF Transcriptional regulator E5N89_19230 ENOG4105VEQ Cold shock protein E5N89_19255 ENOG4105DQ6 Transposase E5N89_19280 ENOG4105MEV Acyl-transferase E5N89_19285 ENOG410688U Inner membrane protein yiaB E5N89_19290 ENOG4105CMG Carbohydrate kinase E5N89_19300 ENOG4105T16 Transcriptional regulator (AraC family) E5N89_19305 ENOG4108UR8 BAX protein E5N89_19310 ENOG4107T9C Alpha amylase catalytic region E5N89_19315 ENOG4105JKW Valine--pyruvate aminotransferase E5N89_19320 ENOG4108XIB electron transport protein ysaA E5N89_19325 ENOG4105J4Q Transcriptional regulator E5N89_19330 ENOG4105DG4 malate L-lactate dehydrogenase E5N89_19335 ENOG4108R66 Conserved Protein E5N89_19340 ENOG4108M5W E5N89_19345 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E5N89_19350 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E5N89_19355 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E5N89_19360 ENOG4105CMG Carbohydrate kinase E5N89_19365 ENOG4105H6Q decarboxylase E5N89_19370 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E5N89_19375 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E5N89_19390 ENOG4105C26 Dehydrogenase E5N89_19395 ENOG41066F8 ROK family E5N89_19400 ENOG4105EM7 Selenocysteine-specific translation elongation factor E5N89_19410 ENOG4108U78 Glutathione S-transferase E5N89_19415 ENOG4105CTS PTS system mannitol-specific E5N89_19425 ENOG4105E61 Mannitol repressor protein E5N89_19435 ENOG4108YYI Protein of unknown function (DUF2810) E5N89_19440 ENOG4108WY4 inner membrane lipoprotein E5N89_19445 ENOG4105EUR Domain-Containing protein E5N89_19450 ENOG4105DAA L-lactate E5N89_19455 ENOG41073TP transcriptional regulator E5N89_19465 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E5N89_19470 ENOG4105ETE Transcriptional regulator (LacI family E5N89_19475 ENOG4105DIA mandelate racemase muconate lactonizing E5N89_19480 ENOG4105DJB Major Facilitator Superfamily E5N89_19485 ENOG4105D7W serine acetyltransferase E5N89_19500 ENOG4105VW4 glutaredoxin 3 E5N89_19505 ENOG4107YZP Rhodanese domain protein E5N89_19515 ENOG41063SB peptidase E5N89_19520 ENOG4105PXI polysaccharide deacetylase E5N89_19525 ENOG4105K64 Glycosyl transferase, family 2 E5N89_19535 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E5N89_19545 ENOG4105XA0 heptosyltransferase ii E5N89_19550 ENOG4105D16 lipopolysaccharide heptosyltransferase i E5N89_19555 ENOG4108FRV O-antigen ligase E5N89_19560 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase E5N89_19565 ENOG4108QD8 lipopolysaccharide core biosynthesis protein E5N89_19570 ENOG4108PDR lipopolysaccharide core biosynthesis protein E5N89_19575 ENOG4105X1N Glycosyl transferase family 8 E5N89_19580 ENOG4106AH0 Glycosyl Transferase E5N89_19585 ENOG4107XU6 Glycosyl transferase (Group 1 E5N89_19600 ENOG4107543 (lipo)polysaccharide E5N89_19605 ENOG4107RJ7 Glycosyl transferase (Group 1 E5N89_19610 ENOG4105DKP glycosyl transferase, family 9 E5N89_19615 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E5N89_19620 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) E5N89_19630 ENOG4105W0E 50S ribosomal protein L33 E5N89_19645 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E5N89_19670 ENOG4105DSJ YicC domain protein E5N89_19685 ENOG4105EN6 Membrane E5N89_19690 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) E5N89_19695 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E5N89_19700 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) E5N89_19705 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5N89_19710 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase E5N89_19715 ENOG4105CB5 ATP-dependent DNA helicase recG E5N89_19725 ENOG4105D6U Sodium Glutamate Symporter E5N89_19730 ENOG4105C2W permease E5N89_19735 ENOG4105JV1 AsmA family E5N89_19740 ENOG4105CJQ hydrolase, family 31 E5N89_19745 ENOG4105CT4 transporter E5N89_19765 ENOG4107WZZ SMC domain protein E5N89_19790 ENOG4105ISV protein with bipartite regulator domain E5N89_19800 ENOG4105FV3 E5N89_19805 ENOG4108TC1 Transcriptional regulator E5N89_19815 ENOG4105CHJ isochorismatase hydrolase E5N89_19830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E5N89_19840 ENOG4108UZ3 Transporter E5N89_19845 ENOG4105DNE Transposase E5N89_19860 ENOG4105F3R pts system mannose fructose sorbose family iid E5N89_19865 ENOG4105ETZ PTS System E5N89_19870 ENOG4108EQA pts system E5N89_19885 ENOG4105T8A Uncharacterized protein YicS E5N89_19890 ENOG4105CS2 ec 3.2.1.21 E5N89_19915 ENOG4105D2N Aldolase E5N89_19925 ENOG4105DT3 PTS system, galactitol-specific IIc component E5N89_19930 ENOG41090UW PTS System E5N89_19940 ENOG4105FDP GntR family transcriptional regulator E5N89_19945 ENOG4108SAJ Protein of unknown function (DUF1198) E5N89_19950 ENOG4105CXY transporter E5N89_19955 ENOG4105CXY transporter E5N89_19960 ENOG4105BZU Histidine kinase E5N89_19965 ENOG4108KX4 response regulator E5N89_19975 ENOG4105EDR glucose galactose transporter E5N89_19980 ENOG4108RVA ribokinase E5N89_19985 ENOG4107FB0 transcriptional regulator DeoR family E5N89_19990 ENOG4105M71 acetolactate synthase 1 regulatory subunit E5N89_19995 ENOG4105C7K acetolactate synthase E5N89_20020 ENOG4105E5M Multidrug resistance protein D E5N89_20030 ENOG4105W8I Transcriptional regulator E5N89_20040 ENOG4105BZC d-serine deaminase E5N89_20045 ENOG4105J13 transcriptional regulator E5N89_20050 ENOG4105JP4 Inner membrane protein yidG E5N89_20055 ENOG4105VG5 Membrane E5N89_20075 ENOG4105R2A (LipO)protein E5N89_20080 ENOG4105D99 atp gtp-binding protein E5N89_20085 ENOG4105KWW Biogenesis protein E5N89_20090 ENOG4107QX9 Thiol disulfide interChange protein E5N89_20095 ENOG4105DA4 cytochrome c-type biogenesis protein E5N89_20100 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) E5N89_20105 ENOG4105X3C heme exporter protein E5N89_20110 ENOG41060IM Heme exporter protein E5N89_20115 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E5N89_20120 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N89_20125 ENOG4105CA0 peroxidase E5N89_20135 ENOG4108EM1 reductase E5N89_20140 ENOG4105CUW cytochrome C-TYPE protein E5N89_20145 ENOG4106WF9 DNA-binding transcriptional regulator TorR E5N89_20150 ENOG4108SV3 Tmao reductase system periplasmic protein tort E5N89_20155 ENOG4105BZU Histidine kinase E5N89_20160 ENOG4105DJB Major Facilitator Superfamily E5N89_20170 ENOG4108RTU Aldolase E5N89_20175 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 E5N89_20180 ENOG4105EMF GntR family transcriptional regulator E5N89_20185 ENOG410667J hydrolase E5N89_20190 ENOG4105DJB Major Facilitator Superfamily E5N89_20195 ENOG4105CXK mandelate racemase muconate lactonizing E5N89_20205 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5N89_20215 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E5N89_20240 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E5N89_20245 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) E5N89_20260 ENOG4107RRE RNA-directed DNA polymerase E5N89_20265 ENOG4105CNH Multidrug resistance protein MdtL E5N89_20270 ENOG4105G2Y Transcriptional regulator E5N89_20275 ENOG4105E8Q phosphopantetheinyl transferase E5N89_20280 ENOG4108YYH Nadph-dependent fmn reductase E5N89_20285 ENOG4105C7N Xanthine uracil vitamin C permease E5N89_20290 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 E5N89_20305 ENOG4105E2Z phosphate ABC transporter (Permease E5N89_20310 ENOG4105C8U phosphate abc transporter E5N89_20315 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) E5N89_20320 ENOG4105DM4 PTS System E5N89_20325 ENOG4105F9E Shikimate 5-dehydrogenase E5N89_20330 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E5N89_20335 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5N89_20350 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) E5N89_20380 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E5N89_20390 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation E5N89_20405 ENOG4105QTB Flavodoxin E5N89_20410 ENOG4108VVK transcriptional Regulator, AsnC E5N89_20415 ENOG4105CU9 asparagine synthetase A E5N89_20425 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) E5N89_20440 ENOG4105C2J ABC transporter E5N89_20445 ENOG4105CNN ABC, transporter E5N89_20450 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E5N89_20455 ENOG4108RVA ribokinase E5N89_20460 ENOG4105ETE Transcriptional regulator (LacI family E5N89_20465 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5N89_20470 ENOG4107EJG GntR family transcriptional regulator E5N89_20515 ENOG4105C0P Mg chelatase subunit ChlI E5N89_20530 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit E5N89_20535 ENOG4105CM2 brancheD-chain amino acid aminotransferase E5N89_20545 ENOG4105C7B Threonine dehydratase E5N89_20560 ENOG4105EMY transcriptional regulator E5N89_20565 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase E5N89_20570 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E5N89_20580 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E5N89_20585 ENOG4105C4R Atp-dependent dna helicase E5N89_20600 ENOG4105K63 Thioredoxin E5N89_20610 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E5N89_20615 ENOG4105ESV Glycosyl transferase, family 4 E5N89_20620 ENOG4105SFE lipopolysaccharide biosynthesis protein E5N89_20625 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E5N89_20630 ENOG4108IJ1 Dehydrogenase E5N89_20635 ENOG4105C1B dTDP-glucose 4-6-dehydratase E5N89_20640 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5N89_20640 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E5N89_20645 ENOG4108WJ1 acetyltransferase E5N89_20650 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E5N89_20655 ENOG4105EGZ biosynthesis protein E5N89_20660 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) E5N89_20665 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) E5N89_20675 ENOG4105C85 amino acid E5N89_20700 ENOG410601J HemY protein E5N89_20705 ENOG4105ECF c-methyltransferase E5N89_20710 ENOG41076E6 Uroporphyrinogen-III Synthase E5N89_20720 ENOG4107T0K Adenylate cyclase E5N89_20740 ENOG4105XQ6 frataxin-like protein E5N89_20755 ENOG4105S7Z (LipO)protein E5N89_20765 ENOG4105CT0 Protein of unknown function, DUF484 E5N89_20770 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5N89_20775 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant E5N89_20780 ENOG4105C4R Atp-dependent dna helicase E5N89_20790 ENOG4105NRM Membrane E5N89_20795 ENOG4106WR8 Inner membrane protein YigG E5N89_20800 ENOG4105FR1 rard protein E5N89_20805 ENOG4108VUY thioesterase Superfamily protein E5N89_20810 ENOG4105HDD phospholipase E5N89_20815 ENOG4105C9U ATP-dependent DNA helicase RecQ E5N89_20820 ENOG4105CCF Lysine exporter protein (Lyse ygga) E5N89_20825 ENOG410829K Lysine exporter protein (Lyse ygga) E5N89_20830 ENOG4108EUD Lysophospholipase E5N89_20835 ENOG4105DQF Hydrolase E5N89_20840 ENOG4105EMK carboxylate amino acid amine transporter E5N89_20845 ENOG4105DZ2 Transcriptional regulator E5N89_20860 ENOG4105C4X radical SAM domain protein E5N89_20865 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) E5N89_20870 ENOG4108I5U Uridine phosphorylase E5N89_20875 ENOG4105CGY Dna recombination protein E5N89_20885 ENOG4105JC1 sterol-binding domain protein E5N89_20895 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E5N89_20905 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E5N89_20910 ENOG4105F8V Hydrolase, tatD family E5N89_20915 ENOG4105MDZ Transcriptional activator rfaH E5N89_20920 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E5N89_20925 ENOG4107QK7 reductase E5N89_20930 ENOG4108MR7 Arylsulfotransferase E5N89_20940 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) E5N89_20950 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E5N89_20955 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) E5N89_20960 ENOG4108RR8 protoporphyrinogen oxidase E5N89_20990 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b E5N89_20995 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E5N89_21000 ENOG4105PC1 Conserved Protein E5N89_21005 ENOG4105E27 serine threonine protein kinase E5N89_21015 ENOG4106HNH Acyl-transferase E5N89_21020 ENOG4105C2M dna polymerase I E5N89_21040 ENOG4105D4P Coproporphyrinogen iii oxidase E5N89_21045 ENOG4106FIY E5N89_21050 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N89_21055 ENOG4105CUX Signal transduction histidine kinase E5N89_21060 ENOG4105C5F glutamine synthetase E5N89_21070 ENOG4108K4B hydrolase E5N89_21100 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is E5N89_21105 ENOG4105CT4 transporter E5N89_21110 ENOG4105CT4 transporter E5N89_21115 ENOG4105CJQ hydrolase, family 31 E5N89_21120 ENOG4107WI4 Aldose-1-epimerase E5N89_21125 ENOG4107QKS N-acylglucosamine 2-epimerase E5N89_21130 ENOG4105D2M Aldolase E5N89_21135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5N89_21140 ENOG4108MGF sugar kinase E5N89_21145 ENOG4105E98 transcriptional regulator DeoR family E5N89_21150 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 E5N89_21155 ENOG4107S2Z UPF0761 membrane protein E5N89_21165 ENOG4105SUU thioesterase domain E5N89_21170 ENOG4108Z3N Transcriptional regulator E5N89_21175 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) E5N89_21185 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system E5N89_21200 ENOG4108MG3 formate dehydrogenase E5N89_21205 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N89_21220 ENOG4108V87 frv operon regulatory protein E5N89_21225 ENOG4108V87 frv operon regulatory protein E5N89_21235 ENOG4108UMN azlc family E5N89_21250 ENOG4105C0A alcohol dehydrogenase E5N89_21260 ENOG4105DKG l-rhamnose isomerase E5N89_21265 ENOG4105DET Rhamnulokinase E5N89_21285 ENOG4108QGT oligogalacturonate-specific porin E5N89_21290 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E5N89_21295 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E5N89_21300 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E5N89_21305 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5N89_21310 ENOG4108RPX mosc domain containing protein E5N89_21320 ENOG4105E0F Histidine kinase E5N89_21325 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5N89_21330 ENOG4105FMW periplasmic E5N89_21345 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E5N89_21355 ENOG4105CT4 transporter E5N89_21360 ENOG4105D7K pfkb domain protein E5N89_21380 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) E5N89_21390 ENOG4107RYS Autoinducer-2 (AI-2) kinase E5N89_21395 ENOG4105DKT Transcriptional regulator E5N89_21400 ENOG4105C2J ABC transporter E5N89_21415 ENOG4105D4B ABC, transporter E5N89_21425 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound E5N89_21440 ENOG4105EBK exported protein E5N89_21445 ENOG4108VTS Membrane E5N89_21450 ENOG4105DP0 ferredoxin-NADP reductase E5N89_21455 ENOG4105CBT Fructose-1,6-bisphosphatase E5N89_21465 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E5N89_21470 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) E5N89_21480 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E5N89_21495 ENOG41063M6 Cell Division Protein E5N89_21500 ENOG4105ETE Transcriptional regulator (LacI family E5N89_21505 ENOG4105C25 Primosomal protein n' E5N89_21520 ENOG4108MR7 Arylsulfotransferase E5N89_21530 ENOG4105C28 cystathionine E5N89_21535 ENOG4105CFH Aspartokinase E5N89_21540 ENOG4105D64 Mechanosensitive ion channel E5N89_21555 ENOG4105CGH 5'-nucleotidase E5N89_21560 ENOG4105SYT Methylenetetrahydrofolate reductase E5N89_21570 ENOG4108XC3 NADH ubiquinone oxidoreductase E5N89_21575 ENOG4105DCT glycerol dehydrogenase E5N89_21585 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E5N89_21590 ENOG4105DM4 PTS System E5N89_21595 ENOG4108YRF PTS System E5N89_21600 ENOG4105C6N Formate acetyltransferase E5N89_21605 ENOG4108AHH pyruvate formate lyase II activase E5N89_21610 ENOG4108XCZ PTS System E5N89_21615 ENOG4106R3P AraC family transcriptional regulator E5N89_21620 ENOG4105DIJ Phosphoethanolamine transferase E5N89_21630 ENOG4105CWC Acetylornithine deacetylase E5N89_21635 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase E5N89_21645 ENOG4105CH7 arginosuccinase E5N89_21650 ENOG4105C5Q Transcriptional regulator E5N89_21665 ENOG4108Y73 Membrane E5N89_21675 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) E5N89_21705 ENOG4105D4A Cell wall formation (By similarity) E5N89_21710 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase E5N89_21745 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E5N89_21750 ENOG4105PM1 preprotein translocase subunit SecE E5N89_21755 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E5N89_21775 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) E5N89_21815 ENOG4105D41 biosynthesis protein thiH E5N89_21820 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) E5N89_21825 ENOG4105WHD thiamine biosynthesis protein ThiS E5N89_21830 ENOG4105D06 uba thif-type nad fad binding protein E5N89_21835 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E5N89_21850 ENOG4105E09 nadh pyrophosphatase E5N89_21865 ENOG4105R2J Conserved Protein E5N89_21870 ENOG4105K70 DNA-binding protein E5N89_21875 ENOG4108T8B Protein of unknown function (DUF1481) E5N89_21885 ENOG4105BZU Histidine kinase E5N89_21890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5N89_21895 ENOG4105C12 Phosphoribosylglycinamide synthetase E5N89_21900 ENOG4105DC1 bifunctional purine biosynthesis protein purh E5N89_21930 ENOG4105K5X acetyltransferase E5N89_21940 ENOG4107QP3 malate synthase g E5N89_21945 ENOG4108I9X Isocitrate lyase E5N89_21960 ENOG41069M3 Transcriptional regulator E5N89_21965 ENOG4105C3R Methionine synthase E5N89_21970 ENOG4105EAM Na Pi-cotransporter E5N89_21975 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) E5N89_21985 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E5N89_21990 ENOG4105FE9 pseudouridine synthase E5N89_21995 ENOG4108ZR5 Conserved Protein E5N89_22000 ENOG4105C09 Bile acid E5N89_22025 ENOG4108X9F tail fiber protein E5N89_22050 ENOG4105CKK Glycosyl transferase, family 2 E5N89_22055 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E5N89_22135 ENOG4105CFH Aspartokinase E5N89_22150 ENOG4108MDC (LipO)protein E5N89_22155 ENOG4108Q9C Periplasmic Protein E5N89_22160 ENOG4105E3R (LipO)protein E5N89_22170 ENOG4105EG2 ABC transporter, permease E5N89_22175 ENOG4105D56 permease protein E5N89_22180 ENOG4107FKK extracellular solute-binding protein family 1 E5N89_22200 ENOG4107W52 maltose operon periplasmic protein E5N89_22220 ENOG41080IJ Diacylglycerol kinase E5N89_22230 ENOG4107R73 Mate efflux family protein E5N89_22240 ENOG4105VDW Csbd family E5N89_22245 ENOG4105MYN Zinc uptake regulation protein E5N89_22280 ENOG41077V0 CPS-53 (KpLE1) prophage E5N89_22285 ENOG4108R7K Metal Dependent Phosphohydrolase E5N89_22290 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) E5N89_22295 ENOG4105H40 E5N89_22320 ENOG4105RDA repressor E5N89_22325 ENOG41078CG DNA-binding transcriptional regulator E5N89_22330 ENOG4108S1U E5N89_22340 ENOG4105YQ0 E5N89_22355 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E5N89_22360 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) E5N89_22370 ENOG4108MXB Protein of unknown function (DUF968) E5N89_22375 ENOG4105HGD Antitermination protein E5N89_22400 ENOG4105NVB glycoside hydrolase, family 19 E5N89_22430 ENOG4105CAR Terminase, large subunit E5N89_22440 ENOG4105EFC phage portal protein HK97 family E5N89_22485 ENOG4105TKZ Tail Sheath E5N89_22515 ENOG4108NKR DNA circulation protein E5N89_22535 ENOG4108T86 baseplate J family protein E5N89_22540 ENOG4105Y0G tail protein E5N89_22545 ENOG4105Y9F tail fiber protein E5N89_22555 ENOG4105UZW Tail fiber assembly protein E5N89_22570 ENOG4108C33 Resolvase E5N89_22580 ENOG4106FE3 DNA repair E5N89_22590 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5N89_22595 ENOG4105P4Z Phage shock protein G E5N89_22600 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E5N89_22605 ENOG4105CDU Replicative dna helicase E5N89_22610 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E5N89_22615 ENOG4105CGF Aromatic amino acid aminotransferase E5N89_22620 ENOG4105F0S class B acid phosphatase E5N89_22625 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme E5N89_22630 ENOG4105MSB protein, conserved in bacteria E5N89_22645 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E5N89_22650 ENOG4108UUM single-stranded DNA-binding protein E5N89_22690 ENOG4105PMV Membrane E5N89_22695 ENOG4108M8H domain protein E5N89_22700 ENOG4108W3Q Transcriptional regulator E5N89_22705 ENOG4108Z4X TRANSCRIPTIONal E5N89_22715 ENOG4105C7N Xanthine uracil vitamin C permease E5N89_22720 ENOG4105EEQ Na H antiporter E5N89_22725 ENOG4105CMU LysR family (Transcriptional regulator E5N89_22735 ENOG41067MG lrgb family E5N89_22745 ENOG41062QD Membrane E5N89_22750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E5N89_22755 ENOG4105EAU Plays a role in nitrite reduction (By similarity) E5N89_22760 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit E5N89_22765 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E5N89_22770 ENOG4105DVI reductase, NrfD E5N89_22775 ENOG4108QKW cytochrome c-type biogenesis protein E5N89_22780 ENOG4108W0S formate-dependent nitrite reductase complex E5N89_22785 ENOG4105CK2 sodium dicarboxylate symporter E5N89_22790 ENOG41082ND Uncharacterized protein yjcO E5N89_22805 ENOG410870W N-acetyltransferase E5N89_22810 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase E5N89_22815 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E5N89_22820 ENOG4105CSH Transporter E5N89_22830 ENOG4105ECM Sensor protein basS pmrB E5N89_22835 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5N89_22840 ENOG4105DIJ Phosphoethanolamine transferase E5N89_22845 ENOG4105D5Q Arginine ornithine antiporter E5N89_22850 ENOG4106ZGR Transcriptional regulator E5N89_22855 ENOG4105CXN decarboxylase E5N89_22860 ENOG4108K2B transcriptional regulator E5N89_22865 ENOG4105F8D glycoside hydrolase family 4 E5N89_22870 ENOG4105CT4 transporter E5N89_22875 ENOG4107GFK fumarate E5N89_22880 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E5N89_22890 ENOG4108MRH transcriptional regulatory protein E5N89_22895 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E5N89_22900 ENOG4107QY8 reductase E5N89_22905 ENOG4105QAX Iron-sulfur E5N89_22910 ENOG4107KGK dmso reductase anchor subunit E5N89_22915 ENOG4108NEM leader-binding protein dmsD E5N89_22925 ENOG4108ZK4 sdia-regulated domain-containing protein E5N89_22940 ENOG41068CG regulatoR E5N89_22965 ENOG4105SBG acid phosphatase E5N89_23000 ENOG4105CDU Replicative dna helicase E5N89_23045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E5N89_23060 ENOG4108UUM single-stranded DNA-binding protein E5N89_23325 ENOG410624V efflux system protein E5N89_23355 ENOG4105DR5 peptidase E5N89_23365 ENOG4105E3B Multicopper oxidase E5N89_23370 ENOG4105VR0 copper resistance E5N89_23375 ENOG4105JDN Copper resistance protein E5N89_23380 ENOG4108PG2 copper resistance E5N89_23385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5N89_23390 ENOG4105GR3 Histidine kinase E5N89_23400 ENOG41088T4 Helicase IV E5N89_23420 ENOG4108SIC Transcriptional regulator E5N89_23425 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5N89_23435 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E5N89_23440 ENOG4108IJ0 Aspartate ammonia-lyase E5N89_23445 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 E5N89_23450 ENOG4105DVH amino acid E5N89_23465 ENOG4108ZVF (LipO)protein E5N89_23470 ENOG4105MTB Uncharacterized protein YjeJ E5N89_23475 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E5N89_23490 ENOG4106BSU Entericidin B E5N89_23500 ENOG4105KPY Small multidrug resistance protein E5N89_23520 ENOG4105E33 succinate dehydrogenase E5N89_23525 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E5N89_23535 ENOG4107SC7 Inner membrane transporter yjeM E5N89_23545 ENOG4105EGS Mechanosensitive ion channel E5N89_23565 ENOG4106TNF Periplasmic binding protein E5N89_23585 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E5N89_23590 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E5N89_23595 ENOG4105K8N protein family UPF0079, ATPase E5N89_23600 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E5N89_23605 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E5N89_23620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E5N89_23625 ENOG4107QJR hflk protein E5N89_23630 ENOG4105EPW hflc protein E5N89_23650 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E5N89_23655 ENOG4105C2N RNA methyltransferase TrmH family group 3 E5N89_23660 ENOG4105FUX Conserved Protein E5N89_23675 ENOG4107VNS Protein of unknown function (DUF2491) E5N89_23680 ENOG4105Z6B inner membrane protein yjfl E5N89_23685 ENOG4108KXT Conserved Protein E5N89_23690 ENOG4106032 Glutathionylspermidine synthase E5N89_23695 ENOG4105CSU acyl-Coa dehydrogenase E5N89_23700 ENOG4105S17 UPF0379 protein yjfN E5N89_23705 ENOG4105WSB biofilm stress and motility protein A E5N89_23710 ENOG4108MXZ Esterase E5N89_23725 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E5N89_23745 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E5N89_23755 ENOG4105KIT UPF0379 protein yjfY E5N89_23770 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) E5N89_23780 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E5N89_23795 ENOG4105FHY Opacity-associated protein A E5N89_23800 ENOG4108V1T peptidylprolyl cis-trans isomerase E5N89_23810 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) E5N89_23815 ENOG4105DXC membrane E5N89_23825 ENOG4108RS6 transposase E5N89_23835 ENOG4105KVH Transcriptional regulator E5N89_23840 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E5N89_23845 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E5N89_23850 ENOG4108UUE Transcriptional regulator E5N89_23855 ENOG41061GZ Protein of unknown function (DUF1107) E5N89_23860 ENOG4105C37 (CBS) domain E5N89_23880 ENOG4108ZHD aig2 family E5N89_23885 ENOG4105DJB Major Facilitator Superfamily E5N89_23890 ENOG41069H0 dihydroorotase EC 3.5.2.3 E5N89_23895 ENOG4105F0N pyrophosphate phospho-hydrolase E5N89_23905 ENOG4105DFU Cell wall formation (By similarity) E5N89_23910 ENOG4105CHC glucokinase (EC 2.7.1.2) E5N89_23915 ENOG4107QNK )-transporter E5N89_23925 ENOG4107QNK )-transporter E5N89_23930 ENOG4105DH8 myo-inositol catabolism E5N89_23935 ENOG4105C26 Dehydrogenase E5N89_23960 ENOG4108MYR Secreted protein E5N89_23965 ENOG4107VG4 Xylose isomerase domain protein TIM barrel E5N89_23975 ENOG4105D7K pfkb domain protein E5N89_23980 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) E5N89_23985 ENOG4105CK5 oxidoreductase E5N89_23990 ENOG4105IE8 Alpha-ketoglutarate permease E5N89_24000 ENOG4105F0H myo-inositol catabolism protein E5N89_24010 ENOG4105CMS peptidase U62, modulator of DNA gyrase E5N89_24015 ENOG4108XVM Cytochrome b(562) E5N89_24045 ENOG41069H0 dihydroorotase EC 3.5.2.3 E5N89_24060 ENOG4105EMD TRANSCRIPTIONal E5N89_24070 ENOG4105K4U addiction module toxin, RelE StbE family E5N89_24075 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E5N89_24080 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E5N89_24085 ENOG4105CG3 alpha amylase, catalytic region E5N89_24095 ENOG4105D4X repressor E5N89_24115 ENOG4105KME endoribonuclease L-psp E5N89_24130 ENOG41077AM PyrBI operon attenuator E5N89_24140 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) E5N89_24145 ENOG4105CSX c4-dicarboxylate anaerobic carrier E5N89_24150 ENOG4105DBV ornithine carbamoyltransferase E5N89_24155 ENOG4105C5B carbamate kinase E5N89_24160 ENOG4105CEU Arginine dihydrolase E5N89_24165 ENOG4105XEP YhcH YjgK YiaL family protein E5N89_24170 ENOG4105DBV ornithine carbamoyltransferase E5N89_24175 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) E5N89_24180 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E5N89_24190 ENOG4108MJ3 acetyltransferase E5N89_24195 ENOG4108M3P Membrane E5N89_24200 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E5N89_24205 ENOG4105MYG DNA polymerase iii, chi subunit E5N89_24215 ENOG4108M8S permease YjgP YjgQ family protein E5N89_24220 ENOG4108K5H permease YjgP YjgQ family protein E5N89_24225 ENOG4105K2J Transcriptional regulator E5N89_24230 ENOG4105C6Z Gluconate E5N89_24235 ENOG4105CHR reductase E5N89_24240 ENOG4105CPQ Dehydrogenase E5N89_24245 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E5N89_24250 ENOG4105DQ4 alcohol dehydrogenase E5N89_24290 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) E5N89_24320 ENOG4105CDY transcriptional regulatory protein E5N89_24325 ENOG4105DTA methyltransferase E5N89_24330 ENOG4105YCT UPF0386 protein E5N89_24335 ENOG4105KZM cytoplasmic protein E5N89_24360 ENOG4105C6F GntR Family Transcriptional Regulator E5N89_24380 ENOG4107YNJ LysR family Transcriptional regulator E5N89_24385 ENOG4105DYB Isoaspartyl dipeptidase E5N89_24390 ENOG4108P2H Inner membrane protein YjiG E5N89_24395 ENOG41074DU domain protein E5N89_24400 ENOG4105CBP Major Facilitator E5N89_24405 ENOG4106BRA Membrane E5N89_24410 ENOG41083G8 Multidrug resistance protein MdtM E5N89_24415 ENOG4105DNE Transposase E5N89_24420 ENOG4105C26 Dehydrogenase E5N89_24445 ENOG4107XZC Restriction modification system DNA (Specificity E5N89_24450 ENOG4105CVR type I restriction-modification system E5N89_24455 ENOG4107SCJ type I restriction enzyme EcoKI subunit R E5N89_24460 ENOG4106H3A restriction E5N89_24475 ENOG4105CKI cobalamin synthesis protein E5N89_24480 ENOG4105VCD cytoplasmic protein E5N89_24485 ENOG4105D22 carbon starvation protein E5N89_24490 ENOG4105C8Q Methyl-accepting chemotaxis E5N89_24505 ENOG4108IQ3 PTS system E5N89_24510 ENOG4105ETZ PTS System E5N89_24515 ENOG4105F3R pts system mannose fructose sorbose family iid E5N89_24520 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5N89_24525 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5N89_24535 ENOG4105RI1 glycoprotein receptor E5N89_24540 ENOG4106CVF DNA replication protein E5N89_24555 ENOG4105DWK Membrane E5N89_24560 ENOG4108N8T regulatoR E5N89_24565 ENOG4108T94 DNA-binding transcriptional activator BglJ E5N89_24570 ENOG4108UIN ybak prolyl-trna synthetase associated region E5N89_24575 ENOG4108819 ferric iron reductase E5N89_24580 ENOG4105BZU Histidine kinase E5N89_24585 ENOG4105YBH Protein of unknown function (DUF1435) E5N89_24610 ENOG4108WPU DNA polymerase III subunit psi E5N89_24615 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E5N89_24620 ENOG4105PAD Hydrolase E5N89_24630 ENOG4105K3G Periplasmic Protein E5N89_24640 ENOG4108NRW Phospholipase, patatin family E5N89_24645 ENOG4105EYA deoxyribonuclease E5N89_24650 ENOG41076CZ activating enzyme E5N89_24655 ENOG4105G0K glycine radical enzyme YjjI family E5N89_24685 ENOG4105E6S usher protein( E5N89_24690 ENOG4108S1B Periplasmic chaperone protein E5N89_24695 ENOG4105UMR response to DNA damage stimulus E5N89_24710 ENOG41062Z9 Membrane E5N89_24715 ENOG4105EAC phosphoserine phosphatase E5N89_24720 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E5N89_24725 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase E5N89_24730 ENOG4105C5H ABC transporter E5N89_24735 ENOG4107SC1 transglycosylase E5N89_24745 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E5N89_24755 ENOG4105UEI Transcriptional Regulator AraC Family E5N89_24760 ENOG4108RH0 Crea protein E5N89_24765 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5N89_24770 ENOG4105EB3 Histidine kinase E5N89_24775 ENOG4105CT7 inner membrane cred family protein E5N89_24790 ENOG4105CW0 outer membrane usher protein E5N89_24795 ENOG4108VCD Chaperone E5N89_24805 ENOG4108PNB DNA-binding transcriptional regulator E5N89_24815 ENOG41065U4 response regulator E5N89_24820 ENOG410759A E5N89_24825 ENOG4106FVC RNA methyltransferase