locus-tag class description E2R47_00025 ENOG4106JVB Replication Protein E2R47_00120 ENOG4105F2I Transposase E2R47_00330 ENOG4108M24 von Willebrand factor, type A E2R47_00335 ENOG4108M24 von Willebrand factor, type A E2R47_00365 ENOG4105DAX Pfam:DUF2983 E2R47_00465 ENOG4105CAF HipA N-terminal domain protein E2R47_00555 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) E2R47_00580 ENOG4105HFT AraC family transcriptional regulator E2R47_00605 ENOG4105EQR Transposase IS116 IS110 IS902 E2R47_00695 ENOG4108KTG Membrane protein, drug metabolite transporter E2R47_00810 ENOG4105EMU Dehydrogenase E2R47_00855 ENOG4105BZU Histidine kinase E2R47_00885 ENOG4108VSE mercuric transport protein E2R47_00890 ENOG4105W1Y Transcriptional regulator E2R47_00895 ENOG4105EQR Transposase IS116 IS110 IS902 E2R47_00915 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) E2R47_00965 ENOG4105I1F Resistance protein E2R47_00995 ENOG4105CJN penicillin-binding protein E2R47_01020 ENOG4105F2I Transposase E2R47_01125 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E2R47_01145 ENOG4105T95 Thiol disulfide interChange protein E2R47_01300 ENOG41074AV Hok/gef family E2R47_01505 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E2R47_01535 ENOG4106JVB Replication Protein E2R47_01570 ENOG4108YXQ IS66 Orf2 family protein E2R47_01590 ENOG4105DFE Dna adenine methylase E2R47_01620 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E2R47_01630 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E2R47_01645 ENOG410667J hydrolase E2R47_01665 ENOG4105BZU Histidine kinase E2R47_01670 ENOG4108SV3 Tmao reductase system periplasmic protein tort E2R47_01675 ENOG4106WF9 DNA-binding transcriptional regulator TorR E2R47_01680 ENOG4105CUW cytochrome C-TYPE protein E2R47_01685 ENOG4108EM1 reductase E2R47_01695 ENOG4105CA0 peroxidase E2R47_01705 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E2R47_01710 ENOG41060IM Heme exporter protein E2R47_01715 ENOG4105X3C heme exporter protein E2R47_01725 ENOG4105DA4 cytochrome c-type biogenesis protein E2R47_01730 ENOG4107QX9 Thiol disulfide interChange protein E2R47_01735 ENOG4105KWW Biogenesis protein E2R47_01740 ENOG4105D99 atp gtp-binding protein E2R47_01745 ENOG4105R2A (LipO)protein E2R47_01765 ENOG4105VG5 Membrane E2R47_01770 ENOG4105JP4 Inner membrane protein yidG E2R47_01775 ENOG4105J13 transcriptional regulator E2R47_01790 ENOG4105W8I Transcriptional regulator E2R47_01800 ENOG4105E5M Multidrug resistance protein D E2R47_01825 ENOG4105C7K acetolactate synthase E2R47_01830 ENOG4105M71 acetolactate synthase 1 regulatory subunit E2R47_01835 ENOG4107FB0 transcriptional regulator DeoR family E2R47_01840 ENOG4108RVA ribokinase E2R47_01845 ENOG4105EDR glucose galactose transporter E2R47_01855 ENOG4108KX4 response regulator E2R47_01860 ENOG4105BZU Histidine kinase E2R47_01865 ENOG4105CXY transporter E2R47_01870 ENOG4105CXY transporter E2R47_01880 ENOG4108SAJ Protein of unknown function (DUF1198) E2R47_01885 ENOG4105FDP GntR family transcriptional regulator E2R47_01895 ENOG41090UW PTS System E2R47_01900 ENOG4105DT3 PTS system, galactitol-specific IIc component E2R47_01910 ENOG4105D2N Aldolase E2R47_01935 ENOG4105CS2 ec 3.2.1.21 E2R47_01940 ENOG4105T8A Uncharacterized protein YicS E2R47_01955 ENOG4108EQA pts system E2R47_01960 ENOG4105ETZ PTS System E2R47_01965 ENOG4105F3R pts system mannose fructose sorbose family iid E2R47_01980 ENOG4105DNE Transposase E2R47_01985 ENOG4108UZ3 Transporter E2R47_01990 ENOG4105KT7 mgtC SapB transporter E2R47_01995 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E2R47_02010 ENOG4105CHJ isochorismatase hydrolase E2R47_02020 ENOG4108TC1 Transcriptional regulator E2R47_02025 ENOG4105FV3 E2R47_02035 ENOG4105ISV protein with bipartite regulator domain E2R47_02055 ENOG4108VEV chaperone E2R47_02060 ENOG4105CW0 outer membrane usher protein E2R47_02070 ENOG4105SYG Fimbrial protein E2R47_02080 ENOG4105P0Q fimbrial-like protein YadC E2R47_02095 ENOG4105CT4 transporter E2R47_02100 ENOG4105CJQ hydrolase, family 31 E2R47_02105 ENOG4105JV1 AsmA family E2R47_02110 ENOG4105C2W permease E2R47_02115 ENOG4105D6U Sodium Glutamate Symporter E2R47_02125 ENOG4105CB5 ATP-dependent DNA helicase recG E2R47_02130 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase E2R47_02135 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E2R47_02140 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) E2R47_02155 ENOG4105EN6 Membrane E2R47_02175 ENOG4105DSJ YicC domain protein E2R47_02200 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E2R47_02215 ENOG4105W0E 50S ribosomal protein L33 E2R47_02230 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E2R47_02235 ENOG4105DKP glycosyl transferase, family 9 E2R47_02240 ENOG4107RJ7 Glycosyl transferase (Group 1 E2R47_02245 ENOG4107543 (lipo)polysaccharide E2R47_02260 ENOG4107XU6 Glycosyl transferase (Group 1 E2R47_02265 ENOG4106AH0 Glycosyl Transferase E2R47_02270 ENOG4105X1N Glycosyl transferase family 8 E2R47_02275 ENOG4108PDR lipopolysaccharide core biosynthesis protein E2R47_02280 ENOG4108QD8 lipopolysaccharide core biosynthesis protein E2R47_02285 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase E2R47_02290 ENOG4108FRV O-antigen ligase E2R47_02295 ENOG4105D16 lipopolysaccharide heptosyltransferase i E2R47_02300 ENOG4105XA0 heptosyltransferase ii E2R47_02310 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E2R47_02320 ENOG4105K64 Glycosyl transferase, family 2 E2R47_02325 ENOG4105PXI polysaccharide deacetylase E2R47_02330 ENOG41063SB peptidase E2R47_02340 ENOG4107YZP Rhodanese domain protein E2R47_02345 ENOG4105VW4 glutaredoxin 3 E2R47_02360 ENOG4105D7W serine acetyltransferase E2R47_02365 ENOG4105DJB Major Facilitator Superfamily E2R47_02370 ENOG4105DIA mandelate racemase muconate lactonizing E2R47_02375 ENOG4105ETE Transcriptional regulator (LacI family E2R47_02380 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E2R47_02390 ENOG41073TP transcriptional regulator E2R47_02395 ENOG4105DAA L-lactate E2R47_02400 ENOG4105EUR Domain-Containing protein E2R47_02405 ENOG4108WY4 inner membrane lipoprotein E2R47_02410 ENOG4108YYI Protein of unknown function (DUF2810) E2R47_02420 ENOG4105E61 Mannitol repressor protein E2R47_02430 ENOG4105CTS PTS system mannitol-specific E2R47_02440 ENOG4105FP6 Protein of unknown function (DUF3302) E2R47_02445 ENOG4105EFX secretion protein, HlyD family E2R47_02450 ENOG4108U78 Glutathione S-transferase E2R47_02460 ENOG4105EM7 Selenocysteine-specific translation elongation factor E2R47_02465 ENOG41066F8 ROK family E2R47_02470 ENOG4105C26 Dehydrogenase E2R47_02490 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E2R47_02495 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E2R47_02500 ENOG4105H6Q decarboxylase E2R47_02505 ENOG4105CMG Carbohydrate kinase E2R47_02510 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E2R47_02515 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E2R47_02520 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E2R47_02525 ENOG4108M5W E2R47_02530 ENOG4108R66 Conserved Protein E2R47_02540 ENOG4105J4Q Transcriptional regulator E2R47_02545 ENOG4108XIB electron transport protein ysaA E2R47_02550 ENOG4105JKW Valine--pyruvate aminotransferase E2R47_02555 ENOG4107T9C Alpha amylase catalytic region E2R47_02560 ENOG4108UR8 BAX protein E2R47_02565 ENOG4105T16 Transcriptional regulator (AraC family) E2R47_02580 ENOG4105CMG Carbohydrate kinase E2R47_02585 ENOG410688U Inner membrane protein yiaB E2R47_02590 ENOG4105MEV Acyl-transferase E2R47_02600 ENOG4105RGS lipoprotein ysaB E2R47_02615 ENOG4105DQ6 Transposase E2R47_02620 ENOG4105DJB Major Facilitator Superfamily E2R47_02625 ENOG4105DIA mandelate racemase muconate lactonizing E2R47_02630 ENOG4107RSM transcriptional regulator E2R47_02635 ENOG410829K Lysine exporter protein (Lyse ygga) E2R47_02655 ENOG4105VEQ Cold shock protein E2R47_02660 ENOG4105MVF Transcriptional regulator E2R47_02665 ENOG4106JH6 (LipO)protein E2R47_02675 ENOG4108ZG0 Ompa motb domain protein E2R47_02680 ENOG4107QY8 reductase E2R47_02685 ENOG4105HNP -acetyltransferase E2R47_02690 ENOG4108R3E Dna-3-methyladenine glycosylase i E2R47_02695 ENOG4105EAX Putative lipase E2R47_02700 ENOG4105DIJ Phosphoethanolamine transferase E2R47_02715 ENOG4105CQ4 Transcriptional regulator E2R47_02730 ENOG4105DEF Extracellular solute-binding protein, family 5 E2R47_02735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E2R47_02740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E2R47_02745 ENOG4105C3U ABC transporter E2R47_02750 ENOG4108JQ7 (ABC) transporter E2R47_02755 ENOG4105C44 Serine transporter E2R47_02770 ENOG4105D1V cellulose synthase operon protein YhjU E2R47_02775 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT E2R47_02785 ENOG410661M cytoplasmic protein E2R47_02790 ENOG4105UTS cellulose synthase operon protein YhjQ E2R47_02795 ENOG4107QZ7 Cellulose synthase catalytic subunit E2R47_02800 ENOG4107EEX Cellulose synthase regulator protein E2R47_02805 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) E2R47_02810 ENOG4105EJG cellulose synthase E2R47_02820 ENOG4105BZU Histidine kinase E2R47_02830 ENOG4105CS0 peptidase E2R47_02835 ENOG4107SS6 2-dehydro-3-deoxygluconokinase E2R47_02840 ENOG4105CMB EAL domain-containing protein E2R47_02845 ENOG41066T0 asmA family E2R47_02850 ENOG4105CSH Transporter E2R47_02855 ENOG4107H3J ribonuclease E2R47_02860 ENOG4105CBN LysR family transcriptional regulator E2R47_02865 ENOG4106S2D Transcriptional regulator E2R47_02885 ENOG4105FDP GntR family transcriptional regulator E2R47_02890 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E2R47_02895 ENOG4108KPW sugar kinase E2R47_02900 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E2R47_02910 ENOG4105DC8 reductase E2R47_02915 ENOG4105D6S protein involved in catabolism of external DNA E2R47_02920 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E2R47_02925 ENOG4105DGW oligopeptidase A E2R47_02935 ENOG4105DUX Transporter E2R47_02940 ENOG4108M6U Universal stress protein A E2R47_02950 ENOG4105CJ3 phosphate transporter E2R47_02955 ENOG4105CBX hi0933 family E2R47_02960 ENOG4105D0S secretion protein (HlyD E2R47_02965 ENOG4105CJ1 ABC, transporter E2R47_02970 ENOG4105CMI transporter E2R47_02980 ENOG4107YAK holo-(acyl carrier protein) synthase 2 E2R47_02985 ENOG4105DSF transport protein E2R47_02995 ENOG4108W1V Lipoprotein E2R47_03000 ENOG4105EX9 Membrane E2R47_03010 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_03020 ENOG4107FS9 Membrane E2R47_03030 ENOG4105MG3 Membrane E2R47_03035 ENOG4106H78 methyltransferase E2R47_03040 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E2R47_03045 ENOG4105CAK Cell division ATP-binding protein ftsE E2R47_03050 ENOG4105CRP Part of the ABC transporter FtsEX involved in E2R47_03060 ENOG4105CP9 extracellular ligand-binding receptor E2R47_03070 ENOG4105U59 -acetyltransferase E2R47_03075 ENOG4105CP9 extracellular ligand-binding receptor E2R47_03080 ENOG4105C32 Amino acid ABC transporter (Permease) E2R47_03085 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E2R47_03090 ENOG4105C0Z ABC transporter E2R47_03095 ENOG4108IV0 ABC, transporter E2R47_03100 ENOG41060M8 Pfam:PhdYeFM E2R47_03110 ENOG4105BZ7 extracellular solute-binding protein family 1 E2R47_03125 ENOG4108IJ9 (ABC) transporter E2R47_03130 ENOG4107T6V glycerophosphoryl diester phosphodiesterase E2R47_03135 ENOG4105WC8 Conserved Protein E2R47_03140 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E2R47_03145 ENOG41080QX K07048 phosphotriesterase-related protein E2R47_03160 ENOG4108RVA ribokinase E2R47_03165 ENOG4105WCN acetyltransferase E2R47_03170 ENOG4105D9R oxidoreductase E2R47_03175 ENOG4105C2I pirin domain protein E2R47_03180 ENOG4105DIQ Transcriptional regulator E2R47_03185 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E2R47_03190 ENOG4105C6Z Gluconate E2R47_03195 ENOG41076UM multiple antibiotic resistance (MarC)-related protein E2R47_03200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E2R47_03205 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E2R47_03225 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E2R47_03230 ENOG4107HP6 Transcriptional regulator E2R47_03235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E2R47_03240 ENOG4105C01 Dihydroxy-acid dehydratase E2R47_03250 ENOG4105DCT glycerol dehydrogenase E2R47_03265 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E2R47_03275 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) E2R47_03280 ENOG4105E98 transcriptional regulator DeoR family E2R47_03285 ENOG4105CYB regulatoR E2R47_03295 ENOG4105E0Y RtcB Protein E2R47_03315 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E2R47_03320 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) E2R47_03325 ENOG4105C6Z Gluconate E2R47_03335 ENOG4105MJ2 Competence protein E2R47_03345 ENOG4105DNE Transposase E2R47_03360 ENOG4105XFK Ferrous iron transport protein A E2R47_03365 ENOG4105BZM domain protein E2R47_03370 ENOG4108RRZ Transcription elongation factor GreB E2R47_03375 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E2R47_03380 ENOG4105E0F Histidine kinase E2R47_03390 ENOG4108MAJ Membrane E2R47_03400 ENOG4105VEJ Heat shock protein E2R47_03405 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E2R47_03410 ENOG4105DQY intracellular growth attenuator E2R47_03415 ENOG4107RK2 ADP-ribose diphosphatase NudE E2R47_03420 ENOG4108JQC penicillin-binding protein 1A E2R47_03425 ENOG4108U1Q Pilus assembly protein E2R47_03430 ENOG41065NF Fimbrial assembly family protein E2R47_03435 ENOG4105XPX DNA utilization protein HofO E2R47_03440 ENOG4105ITY Required for the use of extracellular DNA as a nutrient E2R47_03445 ENOG4105E4G Type IV pilus E2R47_03465 ENOG4105EGB membrane protein DamX E2R47_03470 ENOG4105DFE Dna adenine methylase E2R47_03475 ENOG4105DJV ribulose-phosphate 3-epimerase E2R47_03485 ENOG4105C31 Tryptophanyl-tRNA synthetase E2R47_03490 ENOG4105VYH E2R47_03495 ENOG4107EF2 surface-exposed virulence protein E2R47_03505 ENOG4107V9H nitrite transporter E2R47_03510 ENOG4105WZK nitrite reductase NADPH small subunit E2R47_03515 ENOG4107QZF nitrite reductase NADPH large subunit E2R47_03525 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E2R47_03530 ENOG4106195 uncharacterized protein yhfG E2R47_03535 ENOG4105MZU cell filamentation protein E2R47_03540 ENOG4105DDQ anthranilate synthase E2R47_03545 ENOG4105C8Y Acetylornithine aminotransferase E2R47_03550 ENOG410613R integral membrane protein, YccS YhfK family E2R47_03560 ENOG4108UKZ OsmC family E2R47_03565 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) E2R47_03575 ENOG4105DNZ Alpha Beta Hydrolase E2R47_03580 ENOG4105N0V mono-oxygenase ydhR E2R47_03585 ENOG4108K70 Transcriptional regulator E2R47_03590 ENOG4105C5H ABC transporter E2R47_03605 ENOG4105VKU nucleicacid-binding protein E2R47_03610 ENOG4108YZY peptidylprolyl cis-trans isomerase E2R47_03620 ENOG4108V1T peptidylprolyl cis-trans isomerase E2R47_03625 ENOG4105WWK YheO domain protein E2R47_03650 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) E2R47_03660 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E2R47_03665 ENOG4105W53 bacterioferritin-associated ferredoxin E2R47_03670 ENOG4108UQY Iron-storage protein E2R47_03675 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E2R47_03690 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) E2R47_03705 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E2R47_03710 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) E2R47_03715 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) E2R47_03725 ENOG41083MP 50s ribosomal protein l29 E2R47_03735 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) E2R47_03740 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E2R47_03755 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) E2R47_03765 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) E2R47_03770 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) E2R47_03775 ENOG4105VPB 50S ribosomal protein L30 E2R47_03780 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) E2R47_03785 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E2R47_03790 ENOG41067V7 50S ribosomal protein L36 E2R47_03810 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E2R47_03820 ENOG4105VTS DnaJ-like, subfamily C E2R47_03825 ENOG4105W1Y Transcriptional regulator E2R47_03830 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system E2R47_03840 ENOG4105C1A potassium transporter peripheral membrane E2R47_03845 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E2R47_03860 ENOG4105C79 DNA protecting protein DprA E2R47_03870 ENOG4108WI1 Dna topoisomerase E2R47_03885 ENOG4105SG3 Protein of unknown function (DUF1488) E2R47_03890 ENOG4108Z0R Transferase E2R47_03925 ENOG4105XCM membrane LIPOPROTEIN E2R47_03930 ENOG4105BZS acriflavin resistance protein E2R47_03935 ENOG4105C1P efflux transporter, rnd family, mfp subunit E2R47_03940 ENOG4108XG4 DNA-binding transcriptional regulator E2R47_03950 ENOG41061ME transport protein E2R47_03955 ENOG4105CEC DNA methylase N-4 N-6 E2R47_03960 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) E2R47_03965 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E2R47_03975 ENOG4108IA2 Sodium pantothenate symporter E2R47_03980 ENOG4105RG0 Membrane E2R47_03985 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E2R47_03990 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E2R47_04005 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family E2R47_04010 ENOG41062P1 Diguanylate cyclase phosphodiesterase E2R47_04020 ENOG4105DFF Rod shape-determining protein mreb E2R47_04025 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E2R47_04030 ENOG4105VQ7 Rod shape-determining protein MreD E2R47_04040 ENOG4105C03 ribonuclease E2R47_04045 ENOG4105QD6 exported protein E2R47_04050 ENOG4105D1U peptidase U62 modulator of DNA gyrase E2R47_04055 ENOG4105CR8 Transcriptional regulator E2R47_04060 ENOG4105ZQC membrane protein AaeX E2R47_04075 ENOG4105UNR (Barnase) inhibitor E2R47_04080 ENOG4105RID UPF0379 protein yhcN E2R47_04085 ENOG4105RID UPF0379 protein yhcN E2R47_04100 ENOG4105FDP GntR family transcriptional regulator E2R47_04110 ENOG4105C8P )-transporter E2R47_04115 ENOG4106DSS Tartrate dehydratase subunit alpha E2R47_04120 ENOG4107GFK fumarate E2R47_04130 ENOG4107QSA Oxaloacetate decarboxylase E2R47_04135 ENOG4105D9Q decarboxylase (Beta subunit) E2R47_04150 ENOG4105C0H protease E2R47_04155 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III E2R47_04160 ENOG4105D6Z AFG1 family ATPase E2R47_04175 ENOG4107MKT Stringent starvation protein a E2R47_04180 ENOG4105KB2 stringent starvation protein b E2R47_04205 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) E2R47_04210 ENOG4108R66 Conserved Protein E2R47_04215 ENOG4105DZC cytosine deaminase E2R47_04220 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin E2R47_04225 ENOG4105DFS Conserved Protein E2R47_04230 ENOG4105BZ8 glutamate synthase E2R47_04235 ENOG4105CBC glutamate synthase E2R47_04240 ENOG4105N5T Radical SAM Protein E2R47_04245 ENOG4105BZU Histidine kinase E2R47_04250 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain E2R47_04260 ENOG4108NIH transferase activity, transferring phosphorus-containing groups E2R47_04270 ENOG41080Z8 PHOSPHOCARRIER protein E2R47_04280 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN E2R47_04285 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA E2R47_04290 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E2R47_04295 ENOG4108IUZ ABC transporter E2R47_04300 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E2R47_04305 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) E2R47_04310 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E2R47_04315 ENOG4105C2X Arabinose 5-phosphate isomerase E2R47_04320 ENOG4105FEU K -dependent Na -Ca exchanger E2R47_04325 ENOG4105DHJ ABC, transporter E2R47_04330 ENOG4105CY3 ABC transporter, permease E2R47_04335 ENOG4107PE3 Mammalian cell entry related domain protein E2R47_04340 ENOG4105E3I toluene tolerance E2R47_04345 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane E2R47_04350 ENOG4105VFK BolA family E2R47_04360 ENOG4105HVQ Regulatory factor of maltose metabolism E2R47_04365 ENOG4105EAH synthase E2R47_04380 ENOG4105QYV Membrane E2R47_04390 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase E2R47_04395 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E2R47_04400 ENOG4105HBR Rna-binding protein E2R47_04405 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) E2R47_04410 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E2R47_04415 ENOG4105EEI dihydropteroate synthase E2R47_04455 ENOG4105CHV Transcription elongation factor NusA E2R47_04495 ENOG4105C1J atp-dependent rna helicase E2R47_04500 ENOG4105CIC tryptophan-specific transport protein E2R47_04505 ENOG4105DEN Luciferase family E2R47_04510 ENOG4106RZ4 Peptidase U32 E2R47_04515 ENOG4105CFP Peptidase U32 E2R47_04520 ENOG4105XPQ lipid carrier protein E2R47_04525 ENOG4108YYD acetyltransferase E2R47_04540 ENOG4107R7Y intracellular protease Pfpi family E2R47_04545 ENOG4105K4T epimerase E2R47_04550 ENOG4105W4M Transport-associated protein E2R47_04565 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) E2R47_04570 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E2R47_04580 ENOG4107WTH Galactitol-1-phosphate dehydrogenase E2R47_04585 ENOG4105DT3 PTS system, galactitol-specific IIc component E2R47_04590 ENOG41090UW PTS System E2R47_04595 ENOG41082GB PTS system galactitol-specific transporter subunit IIA E2R47_04610 ENOG4105CTX dehydratase E2R47_04620 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E2R47_04625 ENOG4105BZW Glycerate kinase E2R47_04670 ENOG410811B TRANSCRIPTIONal E2R47_04675 ENOG4105C7B Threonine dehydratase E2R47_04690 ENOG4105C6N Formate acetyltransferase E2R47_04695 ENOG4105EJQ L-serine dehydratase E2R47_04700 ENOG4105C44 Serine transporter E2R47_04710 ENOG4106D80 Uncharacterized protein YhaL E2R47_04715 ENOG4108CNN domain protein E2R47_04720 ENOG4105CWB LysR family transcriptional Regulator E2R47_04725 ENOG4105KAF membrAne E2R47_04730 ENOG4105CHF Glutathione S-transferase E2R47_04735 ENOG4108VBZ doxx family E2R47_04740 ENOG4105YJD E2R47_04745 ENOG41090KG Inner membrane protein YqjE E2R47_04750 ENOG4105NE1 Conserved Protein E2R47_04755 ENOG4105WAY exported protein E2R47_04765 ENOG4106W5V Membrane E2R47_04775 ENOG4105DU1 integral membrane protein, terc E2R47_04780 ENOG4105EE0 oxidoreductase E2R47_04785 ENOG4108UB4 uncharacterized protein ygjQ E2R47_04790 ENOG4108VKG metal-dependent hydrolase E2R47_04800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E2R47_04810 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor E2R47_04815 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_04820 ENOG4105NTW Transcriptional regulator E2R47_04825 ENOG4105Q26 Siderophore-interacting protein E2R47_04840 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E2R47_04845 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E2R47_04850 ENOG4105VCC 30S ribosomal protein S21 E2R47_04870 ENOG4107ZVW dihydroneopterin aldolase E2R47_04885 ENOG4106MWK domain protein E2R47_04890 ENOG4105I7R Adenylate cyclase E2R47_04910 ENOG4107S78 Band 7 protein E2R47_04915 ENOG4105PV3 Inner membrane protein yqiJ E2R47_04925 ENOG4105W0Z cytoplasmic protein E2R47_04945 ENOG4108MR7 Arylsulfotransferase E2R47_04955 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E2R47_04960 ENOG4106032 Glutathionylspermidine synthase E2R47_04975 ENOG41087AY ADP-Ribose pyrophosphatase E2R47_04980 ENOG4108SX3 cytoplasmic protein E2R47_04985 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E2R47_04990 ENOG4105IPS esterase E2R47_04995 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E2R47_05000 ENOG4105VRH Antibiotic biosynthesis monooxygenase E2R47_05005 ENOG4105NF4 modulator of drug activity E2R47_05010 ENOG4105DHQ Histidine kinase E2R47_05015 ENOG4105XJC Two component transcriptional regulator (Winged helix family E2R47_05020 ENOG4105H4F exported protein E2R47_05025 ENOG4105F4I Transcriptional regulator E2R47_05030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E2R47_05035 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E2R47_05040 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E2R47_05045 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E2R47_05055 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E2R47_05060 ENOG4105CCT upf0313 protein E2R47_05080 ENOG4107QPK )-transporter E2R47_05085 ENOG4105CV8 reductase E2R47_05090 ENOG4108I6A alcohol dehydrogenase E2R47_05095 ENOG4105CF7 AraC family transcriptional regulator E2R47_05100 ENOG4108K81 inner membrane protein YghB E2R47_05105 ENOG4105C28 cystathionine E2R47_05110 ENOG4105CWK Biopolymer transport protein, ExbB E2R47_05115 ENOG4108ZZF transport protein (ExbD) E2R47_05120 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E2R47_05145 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_05150 ENOG410900S Protein of unknown function (DUF2623) E2R47_05155 ENOG4105E3S small subunit E2R47_05160 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E2R47_05165 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit E2R47_05170 ENOG4105DPX Hydrogenase, large subunit E2R47_05175 ENOG4108USZ hydrogenase E2R47_05180 ENOG4108WGS hydrogenase 2-specific chaperone E2R47_05185 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E2R47_05190 ENOG41082MF Hydrogenase assembly chaperone hypC hupF E2R47_05195 ENOG4105S10 periplasmic binding protein E2R47_05200 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein E2R47_05205 ENOG4105CYM Glutathione S-transferase E2R47_05210 ENOG4106032 Glutathionylspermidine synthase E2R47_05230 ENOG4105DEI Mannitol dehydrogenase E2R47_05240 ENOG4105DPW Major facilitator superfamily MFS_1 E2R47_05265 ENOG4105C26 Dehydrogenase E2R47_05270 ENOG4105CJP fad dependent oxidoreductase E2R47_05280 ENOG4105CUB amino acid E2R47_05290 ENOG4108UAJ Transcriptional regulator E2R47_05300 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E2R47_05310 ENOG4105CI0 Citrate lyase E2R47_05315 ENOG4105DJG MaoC domain protein dehydratase E2R47_05320 ENOG4105CYC Transferase E2R47_05325 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase E2R47_05350 ENOG4105E3J oxidoreductase E2R47_05355 ENOG41066GK UPF0379 protein ykgI E2R47_05360 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E2R47_05375 ENOG4108UQV Membrane E2R47_05380 ENOG4105CXN decarboxylase E2R47_05385 ENOG4105EAA nucleoside E2R47_05400 ENOG4105CEN a g-specific adenine glycosylase E2R47_05410 ENOG41090ED Protein with unknown function (DUF469) E2R47_05415 ENOG4105K33 Periplasmic Protein E2R47_05420 ENOG4105HDK L-asparaginase E2R47_05425 ENOG4106MH3 alpha helix chain E2R47_05430 ENOG4105CSA Coproporphyrinogen iii oxidase E2R47_05445 ENOG4108VIA integral membrane protein E2R47_05450 ENOG4105DFA alanine racemase domain protein E2R47_05455 ENOG4105CZX twitching motility protein E2R47_05475 ENOG4105D7Z glutathione synthase E2R47_05480 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E2R47_05485 ENOG4105RWS endonuclease I E2R47_05495 ENOG4107QNK )-transporter E2R47_05520 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) E2R47_05530 ENOG4107YCY Transcriptional regulator E2R47_05540 ENOG4105DEI Mannitol dehydrogenase E2R47_05545 ENOG4105CPQ Dehydrogenase E2R47_05550 ENOG4105DG4 malate L-lactate dehydrogenase E2R47_05555 ENOG4108R66 Conserved Protein E2R47_05570 ENOG4108K0D peptidase, M48 E2R47_05575 ENOG4105CV1 Transketolase (EC 2.2.1.1) E2R47_05580 ENOG4108JJB ABC transporter E2R47_05585 ENOG4108JJB ABC transporter E2R47_05620 ENOG4105D2N Aldolase E2R47_05630 ENOG4108RS6 transposase E2R47_05640 ENOG4105D64 Mechanosensitive ion channel E2R47_05650 ENOG4105MPN Membrane E2R47_05670 ENOG4108JQ1 Dehydrogenase E2R47_05675 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E2R47_05695 ENOG4107RAQ aminopeptidase E2R47_05700 ENOG4105D0A hydroxylase E2R47_05705 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E2R47_05735 ENOG4105CS2 ec 3.2.1.21 E2R47_05745 ENOG4108UT2 hemolysin iii E2R47_05765 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB E2R47_05770 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) E2R47_05775 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E2R47_05780 ENOG4105T95 Thiol disulfide interChange protein E2R47_05785 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E2R47_05795 ENOG4105CRK lysyL-tRNA synthetase E2R47_05810 ENOG4108K5P (LipO)protein E2R47_05835 ENOG4108T1M outer membrane protein x E2R47_05855 ENOG4106P2F Pfam:Pili_assembly_C E2R47_05885 ENOG4108MHD transport protein E2R47_05895 ENOG4105C5Q Transcriptional regulator E2R47_05900 ENOG4105CHU acetyl-coa acetyltransferase E2R47_05915 ENOG4105CHR reductase E2R47_05920 ENOG4107QNK )-transporter E2R47_05930 ENOG4105RQF LysR family Transcriptional regulator E2R47_05935 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E2R47_05940 ENOG4105DDV Transcriptional regulator (LacI family E2R47_05970 ENOG4105CPC Aldo Keto reductase E2R47_05975 ENOG4105SUV lipoprotein YgdR E2R47_05980 ENOG4105EE5 Membrane protein terC E2R47_05995 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E2R47_06015 ENOG4105IPU prepilin peptidase dependent protein A E2R47_06020 ENOG4105JCS prepilin peptidase dependent protein E2R47_06025 ENOG4105SEN Protein of unknown function (DUF2509) E2R47_06030 ENOG4105RVB Prepilin peptidase dependent protein c E2R47_06035 ENOG4105DSY exodeoxyribonuclease V, gamma E2R47_06040 ENOG4107QXK peptidase E2R47_06045 ENOG4107QKA exodeoxyribonuclease V beta E2R47_06050 ENOG4107QYX exodeoxyribonuclease v alpha E2R47_06055 ENOG4108EKC n-acetylglutamate synthase E2R47_06060 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E2R47_06075 ENOG4105CA3 membrane-bound lytic murein transglycosylase E2R47_06080 ENOG4105CUZ uba thif-type nad fad binding protein E2R47_06085 ENOG4105FR1 rard protein E2R47_06090 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E2R47_06095 ENOG4105C9B Cysteine desulfurase E2R47_06100 ENOG4105M5B (LipO)protein E2R47_06105 ENOG4105ETT transcriptional Regulator, LysR family E2R47_06110 ENOG4105M08 Membrane E2R47_06120 ENOG4107EDW L-fucose operon activator E2R47_06130 ENOG4105CMG Carbohydrate kinase E2R47_06140 ENOG4105EDR glucose galactose transporter E2R47_06145 ENOG4107W7X Aldolase E2R47_06150 ENOG4105C0A alcohol dehydrogenase E2R47_06165 ENOG4105EJQ L-serine dehydratase E2R47_06170 ENOG4105C44 Serine transporter E2R47_06175 ENOG4105EWT decarboxylase family E2R47_06195 ENOG4105WP7 tRNA pseudouridine synthase C E2R47_06200 ENOG4105DR9 pseudouridine synthase E2R47_06205 ENOG4105QDK Flavodoxin E2R47_06215 ENOG4105DJB Major Facilitator Superfamily E2R47_06220 ENOG4105EQX glucarate dehydratase E2R47_06225 ENOG4105EQX glucarate dehydratase E2R47_06230 ENOG4105BZW Glycerate kinase E2R47_06235 ENOG4105BZU Histidine kinase E2R47_06240 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E2R47_06245 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E2R47_06265 ENOG4105NEV Fimbrial E2R47_06270 ENOG4108FZ9 Chaperone E2R47_06275 ENOG4106PG1 outer membrane usher protein E2R47_06285 ENOG4105DXN mazG family E2R47_06300 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E2R47_06305 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E2R47_06310 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase E2R47_06345 ENOG4105DTT CRISPR-associated helicase, cas3 E2R47_06360 ENOG41060M0 Crispr-associated protein, cse4 family E2R47_06365 ENOG4108VWQ crispr-associated protein E2R47_06375 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E2R47_06380 ENOG4105PWE CRISPR-associated protein cas2 E2R47_06385 ENOG4108MXK alkaline phosphatase isozyme conversion E2R47_06405 ENOG4105N0Z inner membrane protein ygbE E2R47_06440 ENOG4108K5P (LipO)protein E2R47_06450 ENOG4105KZM cytoplasmic protein E2R47_06455 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E2R47_06460 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E2R47_06470 ENOG4105MVE transcriptional regulator E2R47_06480 ENOG4105G63 Type III effector Hrp-dependent E2R47_06490 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E2R47_06495 ENOG4105EXW epimerase dehydratase E2R47_06500 ENOG4105C6Z Gluconate E2R47_06505 ENOG4105JQN Transcriptional regulator E2R47_06510 ENOG4105C0R drug resistance transporter emrb qaca subfamily E2R47_06545 ENOG4105MEW serine threonine protein phosphatase E2R47_06585 ENOG41090HZ type iii secretion E2R47_06590 ENOG4105K44 type iii secretion E2R47_06595 ENOG4108N8R Invasion protein E2R47_06600 ENOG4108HR8 type iii secretion E2R47_06605 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone E2R47_06610 ENOG4108JIR Flagellum-specific ATP synthase E2R47_06615 ENOG41077MC Secretory protein (Associated with virulence) E2R47_06620 ENOG41078G4 surface presentation of E2R47_06625 ENOG4105T85 surface presentation of antigens protein E2R47_06630 ENOG41075IY surface presentation of antigens protein SpaP E2R47_06640 ENOG4108TN6 type iii secretion E2R47_06645 ENOG4108M6W surface presentation of antigens protein SpaS E2R47_06655 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE E2R47_06665 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC E2R47_06675 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E2R47_06690 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear E2R47_06700 ENOG4108YAB Invasion protein E2R47_06710 ENOG4108RC9 Type III secretion system protein E2R47_06715 ENOG4105Y7Q type iii secretion E2R47_06720 ENOG4106BTR E2R47_06725 ENOG4108RBT type iii secretion E2R47_06760 ENOG4105CC5 ABC transporter E2R47_06765 ENOG4105CC5 ABC transporter E2R47_06780 ENOG4105VXR cytoplasmic protein E2R47_06790 ENOG4105C45 hydrogenase expression formation protein (HypE) E2R47_06795 ENOG4105CQS hydrogenase expression formation protein HypD E2R47_06800 ENOG41083WG hydrogenase assembly chaperone E2R47_06805 ENOG4107RSS Hydrogenase accessory protein HypB E2R47_06810 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E2R47_06820 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA E2R47_06825 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E2R47_06830 ENOG4107R30 NADH dehydrogenase E2R47_06835 ENOG4107TDF Formate hydrogenlyase subunit 4 E2R47_06840 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E2R47_06845 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit E2R47_06850 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E2R47_06855 ENOG4105I6X formate hydrogenlyase maturation E2R47_06860 ENOG4108MG9 hydrogenase 3 maturation protease E2R47_06870 ENOG4108RC0 Electron transport protein E2R47_06875 ENOG4105C8H hydrogenase maturation protein Hypf E2R47_06895 ENOG4105C2X Arabinose 5-phosphate isomerase E2R47_06900 ENOG410804X Transcriptional regulator E2R47_06905 ENOG4105J92 DNA-binding transcriptional activator GutM E2R47_06910 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase E2R47_06915 ENOG4105VI0 Pts system, glucitol sorbitol-specific E2R47_06920 ENOG4105DZY Pts system, glucitol sorbitol-specific E2R47_06925 ENOG410787A Pts system, glucitol sorbitol-specific E2R47_06930 ENOG4105CVE Lytic murein transglycosylase E2R47_06940 ENOG4107TH8 cina domain protein E2R47_06960 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E2R47_06965 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) E2R47_06995 ENOG4107VXZ Hydrolase E2R47_07000 ENOG4105W39 Membrane E2R47_07020 ENOG4105C0R drug resistance transporter emrb qaca subfamily E2R47_07025 ENOG4105CW7 secretion protein, HlyD family E2R47_07030 ENOG4105NTK Transcriptional repressor Mpra E2R47_07040 ENOG4105GIJ Glycine betaine E2R47_07045 ENOG4108HQS Glycine betaine E2R47_07050 ENOG4108IJ7 Glycine betaine E2R47_07060 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E2R47_07065 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E2R47_07075 ENOG4105WAZ (Glutaredoxin-like protein) NrdH E2R47_07085 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E2R47_07095 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) E2R47_07100 ENOG4108WMJ Protein of unknown function (DUF2002) E2R47_07105 ENOG4108RNS Exports L-alanine (By similarity) E2R47_07115 ENOG4108X73 DNA- binding protein E2R47_07125 ENOG4108V62 Rhodanese domain protein E2R47_07130 ENOG41080HT Transcriptional regulator, arsr family E2R47_07135 ENOG4105VPI YqaE family transport protein E2R47_07145 ENOG4109066 lysm domain bon superfamily protein E2R47_07150 ENOG4108PVQ transcriptional regulator E2R47_07155 ENOG4105C85 amino acid E2R47_07160 ENOG4108JPW Aminotransferase E2R47_07165 ENOG4105C26 Dehydrogenase E2R47_07170 ENOG4105D5U fad dependent oxidoreductase E2R47_07200 ENOG4105DHQ Histidine kinase E2R47_07220 ENOG4108MJ5 VirK protein E2R47_07225 ENOG4105VRE Pentapeptide repeat protein E2R47_07240 ENOG4107RNH Outer membrane receptor FepA E2R47_07245 ENOG4105NIV Esterase E2R47_07270 ENOG4108C33 Resolvase E2R47_07305 ENOG4105BZ1 (ABC) transporter E2R47_07325 ENOG4108Z1B Cyclase dehydrase E2R47_07335 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E2R47_07340 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E2R47_07365 ENOG4108JU6 CBS domain protein E2R47_07370 ENOG4106KVJ cytochrome C assembly protein E2R47_07380 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E2R47_07405 ENOG4108KHX Diguanylate cyclase E2R47_07410 ENOG4108WS1 E2R47_07415 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E2R47_07420 ENOG4105EHE chorismate mutase- prephenate dehydrogenase E2R47_07430 ENOG4105CQC Prephenate dehydratase E2R47_07440 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA E2R47_07450 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E2R47_07455 ENOG4105C34 Pseudouridine synthase E2R47_07460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E2R47_07465 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E2R47_07500 ENOG4105CSH Transporter E2R47_07505 ENOG4105T42 (LipO)protein E2R47_07510 ENOG4105JIM Phosphatidylserine synthase E2R47_07515 ENOG4105CD5 CoA-binding domain protein E2R47_07520 ENOG4106IUH DTW domain containing protein E2R47_07525 ENOG4105K63 Thioredoxin E2R47_07530 ENOG4105EIB trna rrna methyltransferase E2R47_07550 ENOG41090KR LysR family transcriptional Regulator E2R47_07555 ENOG4105C1J atp-dependent rna helicase E2R47_07565 ENOG4108IYU L-aspartate oxidase E2R47_07595 ENOG4105WMJ Positive regulator of sigma E, RseC MucC E2R47_07610 ENOG4105C3F Signal peptidase i E2R47_07640 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E2R47_07645 ENOG4105DND Transcriptional regulator E2R47_07650 ENOG4105FCD Major Facilitator E2R47_07655 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E2R47_07660 ENOG4106G6Q Transcriptional regulator E2R47_07675 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB E2R47_07680 ENOG4108Z6B deaminase E2R47_07685 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E2R47_07695 ENOG4108ETH Formylglycinamide ribotide synthetase E2R47_07700 ENOG4107WP9 Histidine kinase E2R47_07705 ENOG4108SKK alpha helix protein E2R47_07710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E2R47_07715 ENOG4108YZA Nitrogen regulatory protein pii E2R47_07720 ENOG4105DUX Transporter E2R47_07725 ENOG4105CXN decarboxylase E2R47_07730 ENOG4105D5Q Arginine ornithine antiporter E2R47_07735 ENOG4108M3R transcriptional activator CadC E2R47_07745 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) E2R47_07750 ENOG4105D8G Major Facilitator superfamily E2R47_07755 ENOG4108MN2 Stationary phase inducible protein CsiE E2R47_07765 ENOG4105D7X high-affinity nickel-transporter E2R47_07770 ENOG410810Y Sulfite reductase E2R47_07775 ENOG4107SHJ sulfite reductase subunit b E2R47_07780 ENOG4105D5B Sulfite reductase, subunit A E2R47_07785 ENOG4107XM9 (LipO)protein E2R47_07790 ENOG4105ECY inositol monophosphatase E2R47_07810 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E2R47_07830 ENOG4108ZIT Ferredoxin, 2FE-2S E2R47_07835 ENOG4105WVQ Fe-S assembly protein IscX E2R47_07845 ENOG4105YYA enhanced serine sensitivity protein SseB E2R47_07860 ENOG4105KHC sulfurtransferase E2R47_07865 ENOG4105DN3 alpha-2-macroglobulin domain protein E2R47_07870 ENOG4108JQB penicillin-binding protein 1C E2R47_07875 ENOG4107QY8 reductase E2R47_07880 ENOG4105QAX Iron-sulfur E2R47_07920 ENOG4105N21 Membrane E2R47_07925 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E2R47_07935 ENOG4105VPD cellular component movement E2R47_07970 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E2R47_08000 ENOG41062G3 Protein of unknown function (DUF2633) E2R47_08010 ENOG4105BZU Histidine kinase E2R47_08015 ENOG4105C9X ppx gppa phosphatase E2R47_08020 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) E2R47_08025 ENOG4108V3E phosphoribosylglycinamide formyltransferase E2R47_08045 ENOG4105C2W permease E2R47_08055 ENOG4105K89 arsenate reductase E2R47_08060 ENOG4105ERG peptidase m48, ste24p E2R47_08065 ENOG4105C02 permease E2R47_08070 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E2R47_08075 ENOG4107QQ0 gntp family E2R47_08080 ENOG4105BZW Glycerate kinase E2R47_08085 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E2R47_08090 ENOG4105RH4 Glycine cleavage system transcriptional repressor E2R47_08100 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E2R47_08110 ENOG4105CGZ zinc metallopeptidase E2R47_08115 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) E2R47_08125 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) E2R47_08130 ENOG4105KUZ arsenate reductase E2R47_08140 ENOG4105BZS acriflavin resistance protein E2R47_08145 ENOG4105BZU Histidine kinase E2R47_08150 ENOG4105BZ8 glutamate synthase E2R47_08165 ENOG4108PVD exported protein E2R47_08175 ENOG4105CV1 Transketolase (EC 2.2.1.1) E2R47_08185 ENOG4105C6K Malic enzyme E2R47_08190 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place E2R47_08195 ENOG4106S4J ethanolamine utilization protein EutP E2R47_08200 ENOG4105NDK ethanolamine utilization protein E2R47_08205 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase E2R47_08210 ENOG4108IJ2 phosphate acetyltransferase E2R47_08215 ENOG4105KNY Microcompartments protein E2R47_08220 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E2R47_08225 ENOG4108EKI Dehydrogenase E2R47_08230 ENOG4107RWI ethanolamine utilization protein eutJ E2R47_08235 ENOG4105C0A alcohol dehydrogenase E2R47_08240 ENOG4105ENY Ethanolamine utilization protein eutH E2R47_08245 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase E2R47_08250 ENOG4105CPD ethanolamine ammonia-lyase E2R47_08260 ENOG4106D67 ethanolamine utilization protein E2R47_08265 ENOG4108X49 Ethanolamine utilization protein EutK E2R47_08270 ENOG4108K3Z AraC family transcriptional regulator E2R47_08290 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E2R47_08300 ENOG4105QZU Inner membrane protein YfeZ E2R47_08305 ENOG4105E7K (LipO)protein E2R47_08310 ENOG4105EZR dyp-type peroxidase family protein E2R47_08315 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr E2R47_08320 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein E2R47_08325 ENOG4108I5D sulfate abc transporter E2R47_08330 ENOG4105ECW sulfate abc transporter E2R47_08335 ENOG4108IJ6 ABC transporter E2R47_08340 ENOG4105C6T cysteine synthase E2R47_08350 ENOG4105M0Y E2R47_08355 ENOG41089BK Glutamine amido-transferase E2R47_08360 ENOG4105CSW GntR family transcriptional regulator E2R47_08375 ENOG4105C5Y PTS System E2R47_08385 ENOG4105KZ7 phosphocarrier protein hpr E2R47_08390 ENOG4105C6T cysteine synthase E2R47_08410 ENOG4105VRT cytoplasmic protein E2R47_08415 ENOG4105DHU Bile acid E2R47_08420 ENOG4108M0I Transcriptional regulator E2R47_08425 ENOG4108NFH Sugar hydrolase E2R47_08430 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) E2R47_08435 ENOG4105EAA nucleoside E2R47_08445 ENOG4105CN8 Transcriptional regulator E2R47_08475 ENOG4105GXM Putative transcription regulator (DUF1323) E2R47_08480 ENOG4105HZG regulatoR E2R47_08495 ENOG4108KMM Diguanylate cyclase E2R47_08500 ENOG4105D9N nucleoside E2R47_08510 ENOG4109076 Conserved Protein E2R47_08515 ENOG4105CPC Aldo Keto reductase E2R47_08525 ENOG4107RA9 decarboxylase E2R47_08540 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E2R47_08545 ENOG410863U PTS System E2R47_08550 ENOG4105DC7 peptidase M24 E2R47_08555 ENOG4105CN9 Peptidase m42 family protein E2R47_08560 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E2R47_08565 ENOG4108CIP transcriptional regulator E2R47_08570 ENOG4105CHM Aminotransferase E2R47_08580 ENOG4105D1S lipid A biosynthesis E2R47_08585 ENOG4105W9M Membrane E2R47_08590 ENOG4105CXY transporter E2R47_08600 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC E2R47_08610 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta E2R47_08615 ENOG4108NC2 Outer membrane protease E2R47_08625 ENOG4105S64 Formate nitrite transporter E2R47_08630 ENOG410903C (LipO)protein E2R47_08635 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation E2R47_08640 ENOG4105KZW UPF0381 protein E2R47_08655 ENOG4108BY2 phosphohistidine phosphatase E2R47_08665 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E2R47_08680 ENOG4105EJ9 Membrane E2R47_08685 ENOG4108BPE -transporting atpase E2R47_08690 ENOG4105MH2 YfcL protein E2R47_08695 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E2R47_08700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E2R47_08720 ENOG4105R8V Transcriptional regulator E2R47_08735 ENOG4106WZ1 flagella biosynthesis regulator E2R47_08745 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E2R47_08755 ENOG4105DQR SNARE associated Golgi E2R47_08765 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E2R47_08770 ENOG4108S3P Sporulation domain protein E2R47_08775 ENOG4105E96 Colicin v production protein E2R47_08780 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E2R47_08785 ENOG4108JUB Transcriptional regulator E2R47_08795 ENOG4105E5D amino acid E2R47_08800 ENOG4106M28 alanine racemase domain protein E2R47_08810 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E2R47_08820 ENOG4105E89 ABC transporter E2R47_08825 ENOG4105E89 ABC transporter E2R47_08830 ENOG4105DSP amino acid AbC transporter E2R47_08835 ENOG4106YG3 ABC transporter E2R47_08840 ENOG4108JEH abc transporter atp-binding protein E2R47_08845 ENOG4105ECP epimerase E2R47_08850 ENOG4105CYM Glutathione S-transferase E2R47_08855 ENOG4108SHQ Glutathione S-transferase E2R47_08860 ENOG4108RE9 Phosphodiesterase E2R47_08865 ENOG4105PTV Nudix Hydrolase E2R47_08870 ENOG4105K2J Transcriptional regulator E2R47_08880 ENOG4106ETB IIa component E2R47_08890 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E2R47_08895 ENOG4108HHA Transketolase E2R47_08900 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E2R47_08905 ENOG4105CSX c4-dicarboxylate anaerobic carrier E2R47_08910 ENOG4105C6K Malic enzyme E2R47_08915 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E2R47_08935 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 E2R47_08940 ENOG4107QWE )-transporter E2R47_08955 ENOG4105CHM Aminotransferase E2R47_08965 ENOG4107NQ8 LysR family Transcriptional regulator E2R47_08990 ENOG4105GKE subunit e E2R47_08995 ENOG4107QIZ NADH dehydrogenase E2R47_09000 ENOG4107R0R NADH dehydrogenase subunit g E2R47_09015 ENOG4107UFS subunit j E2R47_09025 ENOG4105D65 subunit l E2R47_09030 ENOG4105C8S subunit m E2R47_09045 ENOG4105CP2 von willebrand factor, type a E2R47_09050 ENOG4107R88 Chemotaxis protein (CheV) E2R47_09060 ENOG4107YB6 acetyltransferase, (GNAT) family E2R47_09065 ENOG4105TNS Conserved Protein E2R47_09070 ENOG4105E4F Isochorismate synthase E2R47_09085 ENOG4108IPT Naphthoate synthase E2R47_09095 ENOG4105CEY Amp-dependent synthetase and ligase E2R47_09100 ENOG4106GZG polymyxin resistance protein B E2R47_09150 ENOG4108UII YfaZ family E2R47_09160 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is E2R47_09170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E2R47_09180 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A E2R47_09185 ENOG4105CXY transporter E2R47_09190 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E2R47_09195 ENOG4105GZI Transcriptional regulator E2R47_09200 ENOG4105CZM Major Facilitator E2R47_09205 ENOG4105XPH Ferredoxin E2R47_09210 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E2R47_09215 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E2R47_09235 ENOG4105CXK mandelate racemase muconate lactonizing E2R47_09240 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E2R47_09245 ENOG4105BZU Histidine kinase E2R47_09250 ENOG41068CG regulatoR E2R47_09255 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC E2R47_09260 ENOG4105FCK Membrane E2R47_09265 ENOG4105CJ2 (LipO)protein E2R47_09270 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E2R47_09275 ENOG4105CF1 Alkylated DNA repair protein E2R47_09280 ENOG4105IBP Cyclic peptide transporter E2R47_09290 ENOG4108ZNS ferredoxin-type protein NapF E2R47_09295 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase E2R47_09305 ENOG4108BGM Quinol dehydrogenase periplasmic component E2R47_09310 ENOG4105GXZ Ferredoxin-type protein NapH E2R47_09315 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) E2R47_09320 ENOG4105CUW cytochrome C-TYPE protein E2R47_09330 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E2R47_09335 ENOG41060IM Heme exporter protein E2R47_09340 ENOG4105X3C heme exporter protein E2R47_09350 ENOG4105DA4 cytochrome c-type biogenesis protein E2R47_09355 ENOG4107QX9 Thiol disulfide interChange protein E2R47_09360 ENOG4105KWW Biogenesis protein E2R47_09365 ENOG4105WH1 Two component transcriptional regulator luxr family E2R47_09395 ENOG4105E68 Sulfatase E2R47_09420 ENOG4105CFI type iii restriction protein res subunit E2R47_09425 ENOG4105I08 Pseudouridine synthase E2R47_09430 ENOG4105C2C drug resistance transporter, Bcr CflA E2R47_09435 ENOG4105HG6 E2R47_09440 ENOG4108JQ5 ABC transporter E2R47_09445 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E2R47_09450 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E2R47_09455 ENOG4105E43 Extracellular solute-binding protein, family 5 E2R47_09460 ENOG4105CXC rtn protein E2R47_09465 ENOG4107TT5 NLP P60 protein E2R47_09470 ENOG41076MN Phosphoesterase, PA-phosphatase related E2R47_09475 ENOG4105CKI cobalamin synthesis protein E2R47_09480 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E2R47_09485 ENOG4105KRS Proteinase inhibitor E2R47_09500 ENOG4105S8Q sugar efflux transporter E2R47_09505 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E2R47_09510 ENOG4105DE4 1-phosphofructokinase E2R47_09515 ENOG4105DM4 PTS System E2R47_09525 ENOG4105HMI Membrane E2R47_09530 ENOG4105DUM transcriptional regulator, lysR family E2R47_09535 ENOG4108IQI permease E2R47_09545 ENOG4105D05 Receptor E2R47_09550 ENOG4105CXY transporter E2R47_09555 ENOG4105EAC phosphoserine phosphatase E2R47_09560 ENOG4105EJQ L-serine dehydratase E2R47_09580 ENOG4105DHF Membrane E2R47_09585 ENOG41060NJ transcriptional regulator E2R47_09590 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator E2R47_09595 ENOG4105C2J ABC transporter E2R47_09600 ENOG4107SDZ Galactoside transport system permease protein mglC E2R47_09605 ENOG4107SJI Dehydrogenase E2R47_09610 ENOG4105BZ8 glutamate synthase E2R47_09615 ENOG4105Y9N Membrane E2R47_09620 ENOG4107GZ4 SanA protein E2R47_09630 ENOG41067MG lrgb family E2R47_09660 ENOG4108RXX maleylacetoacetate isomerase E2R47_09665 ENOG4105MSY salicylate hydroxylase E2R47_09670 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E2R47_09680 ENOG4105ETP RND efflux system, outer membrane lipoprotein E2R47_09685 ENOG4105H9W Short-chain dehydrogenase reductase Sdr E2R47_09690 ENOG4105KHU inner membrane protein YohD E2R47_09695 ENOG41069YE inner membrane protein yohC E2R47_09700 ENOG41061WM D-Alanyl-D-Alanine E2R47_09705 ENOG4105CXG d-lactate dehydrogenase E2R47_09710 ENOG4107QK4 glycoside hydrolase, family 3 domain protein E2R47_09715 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E2R47_09720 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component E2R47_09725 ENOG4108IJ8 ABC transporter E2R47_09730 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component E2R47_09745 ENOG4108HRK Histidine kinase E2R47_09750 ENOG4108NEV two component transcriptional regulator, LytTR family E2R47_09755 ENOG4108W15 Protein of unknown function (DUF1456) E2R47_09765 ENOG4108YCW (LipO)protein E2R47_09775 ENOG4105D1F ATP-binding protein E2R47_09790 ENOG4108MQF Chaperone E2R47_09800 ENOG410662B Type-1 fimbrial protein E2R47_09805 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly E2R47_09815 ENOG4105DWF phosphomethylpyrimidine kinase E2R47_09820 ENOG4105FDP GntR family transcriptional regulator E2R47_09825 ENOG4108TFM Kinase, PfkB family E2R47_09830 ENOG4108KD5 ADP-ribosylation crystallin J1 E2R47_09835 ENOG4105EAA nucleoside E2R47_09840 ENOG4105EIE fructose-bisphosphate aldolase E2R47_09855 ENOG41090V3 Tir chaperone protein (CesT) family E2R47_09865 ENOG4105CFP Peptidase U32 E2R47_09890 ENOG4105E3W Two component transcriptional regulator (Winged helix family E2R47_09895 ENOG4105EB3 Histidine kinase E2R47_09925 ENOG4105R8A Heat shock protein E2R47_09930 ENOG4105D03 DNA-3-methyladenine glycosylase II E2R47_09935 ENOG4105BZU Histidine kinase E2R47_09950 ENOG4108GAE asmA family E2R47_09955 ENOG4105EE5 Membrane protein terC E2R47_09960 ENOG4105DAY polysaccharide export protein E2R47_09965 ENOG4105KJF protein tyrosine phosphatase E2R47_09970 ENOG4105D75 Capsular exopolysaccharide family E2R47_09975 ENOG41090RK glycosyl transferase E2R47_09980 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB E2R47_09985 ENOG4107RXY Glycosyl transferase E2R47_09990 ENOG4108NYJ Colanic acid E2R47_09995 ENOG4105ECJ Glycosyl Transferase E2R47_10000 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF E2R47_10005 ENOG4105C0K Gdp-mannose 4,6-dehydratase E2R47_10010 ENOG4105C30 Nad-dependent epimerase dehydratase E2R47_10015 ENOG4105FGF GDP-mannose mannosyl hydrolase E2R47_10020 ENOG4106CD9 glycosyl transferase group 1 E2R47_10025 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E2R47_10030 ENOG4107QKV phosphomannomutase E2R47_10035 ENOG4105D3Q Sugar transferase E2R47_10040 ENOG4105PSV Polysaccharide Biosynthesis Protein E2R47_10045 ENOG4105C74 pyruvyl transferase E2R47_10050 ENOG4107T8Q Glycosyl transferase (Group 1 E2R47_10055 ENOG4105G1A colanic acid biosynthesis protein E2R47_10060 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E2R47_10065 ENOG4105C1B dTDP-glucose 4-6-dehydratase E2R47_10070 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase E2R47_10075 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E2R47_10080 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase E2R47_10085 ENOG4107QK7 reductase E2R47_10090 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase E2R47_10095 ENOG4105FAW cDP-glucose 4,6-dehydratase E2R47_10100 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E2R47_10125 ENOG4107YYJ Glycosyl transferase, family 2 E2R47_10135 ENOG4107T8Q Glycosyl transferase (Group 1 E2R47_10140 ENOG4105JNK Glycosyl transferase (Group 1 E2R47_10155 ENOG4105D3Q Sugar transferase E2R47_10160 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E2R47_10170 ENOG4105C6Y Udp-glucose 6-dehydrogenase E2R47_10175 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) E2R47_10180 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E2R47_10225 ENOG4108535 NAD dependent epimerase/dehydratase family E2R47_10230 ENOG4105EQ1 Transcriptional regulator E2R47_10240 ENOG4105CUB amino acid E2R47_10245 ENOG4105CJB Exodeoxyribonuclease I E2R47_10260 ENOG4108J2R molybdopterin oxidoreductase E2R47_10265 ENOG4105QAX Iron-sulfur E2R47_10270 ENOG4108NWD Cytochrome E2R47_10275 ENOG4105DZ1 carboxypeptidase E2R47_10280 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) E2R47_10285 ENOG4105DR8 Membrane E2R47_10295 ENOG4105JZC GHMP kinase E2R47_10300 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E2R47_10305 ENOG4105KTW ethanolamine utilization protein E2R47_10310 ENOG4105M3W utilization protein E2R47_10320 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E2R47_10325 ENOG4108EKI Dehydrogenase E2R47_10330 ENOG4108EKI Dehydrogenase E2R47_10340 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E2R47_10350 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) E2R47_10355 ENOG4105S3V Carbon dioxide concentrating mechanism protein E2R47_10360 ENOG4105KNY Microcompartments protein E2R47_10370 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E2R47_10375 ENOG4108ZFT Dehydratase small subunit E2R47_10380 ENOG4105YCI dehydratase medium subunit E2R47_10385 ENOG4105DMB glycerol dehydratase E2R47_10390 ENOG4105EHR propanediol utilization protein pduB E2R47_10395 ENOG4105KNY Microcompartments protein E2R47_10400 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E2R47_10405 ENOG4107XVH Transcriptional regulator E2R47_10410 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E2R47_10415 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) E2R47_10420 ENOG41081F0 Precorrin-8x methylmutase E2R47_10430 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase E2R47_10435 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase E2R47_10440 ENOG4105CIA precorrin-4 C(11)-methyltransferase E2R47_10445 ENOG4108P62 biosynthesis protein (CbiG) E2R47_10450 ENOG4105E4R Precorrin-3B C17-methyltransferase E2R47_10455 ENOG4105QUC reductase E2R47_10460 ENOG4107PPM cobalt chelatase E2R47_10465 ENOG4105DVK Precorrin-2 c20-methyltransferase E2R47_10470 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E2R47_10480 ENOG4108V4M Cobalt abc transporter E2R47_10485 ENOG4108JJB ABC transporter E2R47_10495 ENOG4108YZT Adenosylcobinamide kinase E2R47_10510 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E2R47_10520 ENOG4105UQX Mate efflux family protein E2R47_10565 ENOG4105CNA YD repeat protein E2R47_10575 ENOG4105FYV Amp nucleosidase E2R47_10585 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein E2R47_10590 ENOG4105KVH Transcriptional regulator E2R47_10635 ENOG4105KT5 UmuD protein E2R47_10640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E2R47_10655 ENOG4105FCK Membrane E2R47_10660 ENOG4105Y0K Inner membrane protein YedR E2R47_10665 ENOG4105EST Metal Dependent Phosphohydrolase E2R47_10670 ENOG4105DVF Cytosine-specific methyltransferase E2R47_10675 ENOG41090BB DNA mismatch endonuclease (vsr) E2R47_10680 ENOG4105FDR Membrane E2R47_10685 ENOG4105CKW Inner membrane protein yedI E2R47_10690 ENOG4105VNZ cytoplasmic protein E2R47_10705 ENOG4105YX3 cellular response to acidity E2R47_10715 ENOG4107TKS colanic acid capsular biosynthesis activation protein A E2R47_10720 ENOG4105D19 Role in flagellar biosynthesis (By similarity) E2R47_10725 ENOG4105VS8 Flagellar biosynthetic protein fliq E2R47_10730 ENOG4105CN7 Flagellar biosynthetic protein FliP E2R47_10735 ENOG4105K0P flagellar biosynthesis protein E2R47_10740 ENOG4105DD5 Flagellar motor switch protein E2R47_10745 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E2R47_10750 ENOG4107ZI8 flagellar basal body-associated protein flil E2R47_10755 ENOG4105WF4 Flagellar hook-length control protein E2R47_10760 ENOG4105GSA Flagellar export protein flij E2R47_10765 ENOG4108JIR Flagellum-specific ATP synthase E2R47_10770 ENOG41090PJ Flagellar assembly protein E2R47_10775 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E2R47_10780 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) E2R47_10795 ENOG4105KSU Redox protein E2R47_10800 ENOG41066VF YeeE YedE family protein E2R47_10805 ENOG4105JCU Inherit from NOG: (Lipo)protein E2R47_10820 ENOG4105MQ3 flagellar protein FliS E2R47_10825 ENOG4105DTS flagellar hook-associated E2R47_10835 ENOG4108C80 FliB family E2R47_10840 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E2R47_10845 ENOG4108M9K flagella biosynthesis protein FliZ E2R47_10850 ENOG4105EAB amino acid AbC transporter E2R47_10855 ENOG4105K6H D-cysteine desulfhydrase E2R47_10860 ENOG4105E5Q amino acid AbC transporter E2R47_10865 ENOG4105CDA abc transporter atp-binding protein E2R47_10870 ENOG4105VJY transcriptional regulator E2R47_10875 ENOG4105XVG cytoplasmic protein E2R47_10885 ENOG4105WH1 Two component transcriptional regulator luxr family E2R47_10930 ENOG4106RHG Yeca family E2R47_10935 ENOG4105E0U tyrosine-specific transport protein E2R47_10940 ENOG4105VVZ metal-binding protein E2R47_10945 ENOG41090A1 ferritin E2R47_10950 ENOG4105P23 (LipO)protein E2R47_10960 ENOG4108UEC Ferritin-like protein E2R47_10975 ENOG4108K4C ec 3.1.3.12 E2R47_10985 ENOG4108VA4 Universal stress protein E2R47_10995 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) E2R47_11000 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region E2R47_11005 ENOG4107RD7 Flagellar Motor Protein, MotA E2R47_11010 ENOG4105ER2 Ompa motb domain protein E2R47_11015 ENOG4105CBS Chea signal transduction histidine kinase E2R47_11020 ENOG4108V3W Chemotaxis protein, CheW E2R47_11025 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_11030 ENOG4105BZU Histidine kinase E2R47_11040 ENOG4108VYJ response regulator receiver protein E2R47_11045 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) E2R47_11050 ENOG4105D00 flagellar biosynthetic protein flhB E2R47_11055 ENOG4105D7B Flagellar biosynthesis protein flha E2R47_11060 ENOG4105IRD Flagellar protein FlhE E2R47_11065 ENOG4105F5H Glycosyl Hydrolase Family 88 E2R47_11080 ENOG4106ZCM YecM protein E2R47_11100 ENOG4105WJG Glutathione E2R47_11105 ENOG41081XQ Conserved Protein E2R47_11110 ENOG4105D3W isochorismatase E2R47_11120 ENOG4108TIT dATP pyrophosphohydrolase E2R47_11135 ENOG4107S01 Repressor protein MetJ E2R47_11155 ENOG4105FAV ABC, transporter E2R47_11165 ENOG4105NXV High-affinity zinc uptake system protein E2R47_11170 ENOG4105DR5 peptidase E2R47_11175 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E2R47_11180 ENOG4105CA9 Pyruvate kinase E2R47_11185 ENOG4106KNT transcriptional regulator E2R47_11195 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E2R47_11200 ENOG4105C01 Dihydroxy-acid dehydratase E2R47_11205 ENOG4108UHU Aldolase E2R47_11215 ENOG4105X2V dna damage-inducible protein E2R47_11220 ENOG4105RSZ secreted protein E2R47_11225 ENOG4108Q2J Inner membrane protein YebE E2R47_11230 ENOG4105CUG Oligopeptidase b E2R47_11235 ENOG4105UMD exodeoxyribonuclease X E2R47_11240 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E2R47_11245 ENOG4105MPK DNA polymerase III subunit theta E2R47_11250 ENOG4105FXM Copper resistance protein E2R47_11255 ENOG4108PNC copper resistance E2R47_11260 ENOG4105NKT exported protein E2R47_11265 ENOG4108I1J Integrase E2R47_11345 ENOG4105EUZ Beta-lactamase domain protein E2R47_11365 ENOG4105DWP Membrane E2R47_11390 ENOG4105C22 threonyL-tRNA synthetase E2R47_11455 ENOG41064WM Uncharacterized protein YcgX E2R47_11470 ENOG4108R1E Serine threonine protein phosphatase 1 E2R47_11475 ENOG4105UVW uncharacterized protein yebW E2R47_11480 ENOG4105WT8 Protein of unknown function (DUF1480) E2R47_11490 ENOG4105DY2 Paraquat-inducible protein b E2R47_11495 ENOG4105H2K paraquat-inducible protein a E2R47_11500 ENOG4108ZGC gaf domain protein E2R47_11510 ENOG4105CN1 protease E2R47_11520 ENOG4105C0R drug resistance transporter emrb qaca subfamily E2R47_11525 ENOG4105J4Q Transcriptional regulator E2R47_11540 ENOG4105Q3Y exported protein E2R47_11545 ENOG410610J Protein of unknown function (DUF2627) E2R47_11550 ENOG4105VEQ Cold shock protein E2R47_11555 ENOG4105CJN penicillin-binding protein E2R47_11560 ENOG4105DHI Methyltransferase E2R47_11575 ENOG4105F3R pts system mannose fructose sorbose family iid E2R47_11580 ENOG4105ETZ PTS System E2R47_11585 ENOG4108EQA pts system E2R47_11590 ENOG4105EE5 Membrane protein terC E2R47_11595 ENOG4107XTP (EAL) domain protein E2R47_11600 ENOG4105EJQ L-serine dehydratase E2R47_11610 ENOG4105CRQ synthase (Component I) E2R47_11620 ENOG4105M4H endoribonuclease L-psp E2R47_11625 ENOG4105DVT helicase E2R47_11630 ENOG41072GX Peptidase M22 Glycoprotease E2R47_11635 ENOG4105Y4Z Outer Membrane Lipoprotein E2R47_11640 ENOG4105CEY Amp-dependent synthetase and ligase E2R47_11645 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) E2R47_11655 ENOG4107QMS site-determining protein E2R47_11670 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E2R47_11685 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation E2R47_11710 ENOG4105ED1 spovr family E2R47_11720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E2R47_11730 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A E2R47_11740 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) E2R47_11755 ENOG4105D82 Glutamate dehydrogenase E2R47_11765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E2R47_11770 ENOG4105C4M (Ubiquinol oxidase) subunit I E2R47_11775 ENOG4105MVP hydrogenase-1 operon protein HyaF E2R47_11780 ENOG4108VXY Hydrogenase-1 operon protein HyaE E2R47_11785 ENOG4108USZ hydrogenase E2R47_11790 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E2R47_11800 ENOG4105E3S small subunit E2R47_11820 ENOG4105C3G gtp-binding protein E2R47_11830 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria E2R47_11835 ENOG4105CHH sulfate transporter E2R47_11840 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E2R47_11845 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E2R47_11865 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E2R47_11870 ENOG4108YY7 Invasion gene expression up-regulator SirB E2R47_11875 ENOG41063JG Transcriptional regulator E2R47_11885 ENOG4105EWV Sodium calcium exchanger membrane region E2R47_11890 ENOG4105WS7 Cation transport regulator E2R47_11895 ENOG41090EX DsrE family E2R47_11900 ENOG4105ID0 Putative invasin E2R47_11905 ENOG4105WH1 Two component transcriptional regulator luxr family E2R47_11910 ENOG4105BZU Histidine kinase E2R47_11920 ENOG4105DQQ Major facilitator superfamily MFS_1 E2R47_11925 ENOG4105CRU nitrate reductase, alpha subunit E2R47_11930 ENOG4108IUE nitrate reductase beta subunit E2R47_11935 ENOG4105R3A Nitrate reductase E2R47_11940 ENOG41076YT nitrate reductase, gamma subunit E2R47_11980 ENOG4105CIY formyltetrahydrofolate deformylase E2R47_11990 ENOG4105D78 K07001 NTE family protein E2R47_11995 ENOG4105I93 response regulator E2R47_12000 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E2R47_12015 ENOG4108EKI Dehydrogenase E2R47_12020 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein E2R47_12030 ENOG4107QSI ABC, transporter E2R47_12035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E2R47_12040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E2R47_12045 ENOG4105C3U ABC transporter E2R47_12050 ENOG4108JQ7 (ABC) transporter E2R47_12055 ENOG4105EYW Ion transport protein E2R47_12075 ENOG4105K9H YciI-like protein E2R47_12080 ENOG410822N TonB family E2R47_12085 ENOG4105NAU thioesterase Superfamily protein E2R47_12100 ENOG4105PI0 Ferredoxin E2R47_12105 ENOG4105EIF outer membrane protein W E2R47_12110 ENOG4105WEF catalase E2R47_12115 ENOG4108N8X transition metal ion binding E2R47_12120 ENOG4108Z9Z response to DNA damage stimulus E2R47_12140 ENOG4105DK0 Indole-3-glycerol phosphate synthase E2R47_12145 ENOG4108EFP Anthranilate synthase component II E2R47_12150 ENOG4105CRQ synthase (Component I) E2R47_12160 ENOG4105DB7 PHP domain protein E2R47_12165 ENOG4107RTD sua5 ycio yrdc ywlc family protein E2R47_12170 ENOG4105FE9 pseudouridine synthase E2R47_12175 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E2R47_12180 ENOG4105UBK short-chain dehydrogenase reductase E2R47_12185 ENOG4105ERU peptidase E2R47_12190 ENOG4105RKX Protein of unknown function (DUF2498) E2R47_12195 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E2R47_12200 ENOG4107R11 Transcriptional regulator E2R47_12220 ENOG4107QM5 aconitate hydratase E2R47_12230 ENOG4105EYK Phosphatidylglycerophosphatase B E2R47_12235 ENOG4105Q4A inner membrane protein yciS E2R47_12240 ENOG4105CFV Tetratricopeptide repeat protein E2R47_12250 ENOG4108ZJT translation initiation factor, Sui1 E2R47_12255 ENOG41061RM osmotically inducible lipoprotein E2R47_12260 ENOG4105N2W Transcriptional regulator E2R47_12270 ENOG4105BZU Histidine kinase E2R47_12280 ENOG4105Q4T oxidoreductase E2R47_12285 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E2R47_12310 ENOG4108JQ2 peptide transport system atp-binding protein E2R47_12315 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein E2R47_12320 ENOG4108EU3 peptide transport system, permease E2R47_12365 ENOG4108I5W peptide transport system, permease protein E2R47_12370 ENOG4108J59 Extracellular solute-binding protein, family 5 E2R47_12375 ENOG4105E51 psp operon transcriptional activator E2R47_12380 ENOG41087YS Phage shock protein A E2R47_12385 ENOG4105YYT phage shock protein B E2R47_12390 ENOG4105FM1 phage shock protein C E2R47_12395 ENOG4105NNG Peripheral inner membrane phage-shock protein E2R47_12400 ENOG4105K8Z Phage shock protein E2R47_12405 ENOG4105CM6 amino acid regulated cytosolic protein E2R47_12415 ENOG4108JU8 Transcriptional regulator E2R47_12420 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E2R47_12425 ENOG4107S8C mandelate racemase muconate lactonizing E2R47_12430 ENOG4105KXI murein peptide amidase A E2R47_12435 ENOG4107QSI ABC, transporter E2R47_12445 ENOG4105HEI LysR family (Transcriptional regulator E2R47_12450 ENOG4105CV8 reductase E2R47_12455 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E2R47_12460 ENOG4108XFH Transcriptional regulator E2R47_12475 ENOG4106PHM regulatory protein E2R47_12495 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E2R47_12515 ENOG4105D64 Mechanosensitive ion channel E2R47_12520 ENOG4105S5I Membrane E2R47_12525 ENOG4105Q9Y Universal stress protein E2R47_12535 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E2R47_12540 ENOG4108DG9 Smr protein MutS2 E2R47_12550 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_12565 ENOG4105C1J atp-dependent rna helicase E2R47_12585 ENOG410814C multidrug resistance protein E2R47_12590 ENOG4108RW8 Universal stress protein F E2R47_12595 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) E2R47_12610 ENOG41090X5 Heat shock protein hslJ E2R47_12615 ENOG4105C5I Dehydrogenase E2R47_12620 ENOG4107H52 Dicarboxylate transport E2R47_12625 ENOG410689M (LipO)protein E2R47_12630 ENOG4105WXT Conserved Protein E2R47_12645 ENOG4105CQ7 ATP-dependent helicase E2R47_12650 ENOG4107DB1 DUF218 domain E2R47_12655 ENOG4105CPW cytochrome b561 E2R47_12660 ENOG4108WF3 methyltransferase E2R47_12670 ENOG4105E5Q amino acid AbC transporter E2R47_12680 ENOG4105E5Q amino acid AbC transporter E2R47_12685 ENOG4107R0W ABC transporter E2R47_12695 ENOG4107ZUJ lipid metabolic process E2R47_12725 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_12730 ENOG4105DDW LysR family Transcriptional regulator E2R47_12735 ENOG4105E32 cytoplasmic protein E2R47_12740 ENOG4105EBR Carboxylesterase E2R47_12750 ENOG4108YYC ycei family E2R47_12755 ENOG41073TP transcriptional regulator E2R47_12760 ENOG4105CPQ Dehydrogenase E2R47_12765 ENOG4105DJB Major Facilitator Superfamily E2R47_12770 ENOG4105CHR reductase E2R47_12785 ENOG4108PQ7 sgc region transcriptional regulator E2R47_12790 ENOG4108RK0 3-epimerase E2R47_12795 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E2R47_12800 ENOG4106P19 photosystem i assembly btpa E2R47_12805 ENOG4105DT3 PTS system, galactitol-specific IIc component E2R47_12810 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E2R47_12815 ENOG4105CN9 Peptidase m42 family protein E2R47_12820 ENOG4108Z9I -acetyltransferase E2R47_12825 ENOG4107WE3 acetyltransferase YdcK E2R47_12830 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein E2R47_12835 ENOG41088CC tellurite resistance protein tehB E2R47_12840 ENOG4108KKZ (LipO)protein E2R47_12845 ENOG4105DKK Benzoate E2R47_12850 ENOG4108JCI Transcriptional regulator E2R47_12855 ENOG4105CFP Peptidase U32 E2R47_12860 ENOG4105RR0 Protein of unknown function (DUF2554) E2R47_12880 ENOG4108UQS dipeptidase E2R47_12885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E2R47_12900 ENOG410654E Membrane E2R47_12920 ENOG4105R71 cytoplasmic protein E2R47_12925 ENOG4108T9Y Inner membrane protein ydcZ E2R47_12930 ENOG4108Z7F N-acetyltransferase E2R47_12935 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E2R47_12940 ENOG4108WYP Transcriptional regulator E2R47_12945 ENOG4105CHB tonB-dependent Receptor E2R47_12950 ENOG4108NS2 receptor E2R47_12955 ENOG4105SUV lipoprotein YgdR E2R47_12960 ENOG4105C85 amino acid E2R47_12975 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase E2R47_12980 ENOG4105JAB phenazine biosynthesis protein, phzf family E2R47_12985 ENOG4105D0D Nitrate reductase 2, gamma subunit E2R47_12990 ENOG4108NZN Respiratory nitrate reductase 2 delta chain E2R47_12995 ENOG4108IUE nitrate reductase beta subunit E2R47_13000 ENOG4105CRU nitrate reductase, alpha subunit E2R47_13005 ENOG4107QND Nitrite extrusion protein E2R47_13040 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E2R47_13045 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E2R47_13050 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E2R47_13055 ENOG4108MG3 formate dehydrogenase E2R47_13060 ENOG4105DQ4 alcohol dehydrogenase E2R47_13075 ENOG4105TPS biofilm-dependent modulation protein E2R47_13080 ENOG4108Z9K Osmotically inducible protein E2R47_13100 ENOG4105XXV Acid-resistance protein E2R47_13110 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E2R47_13125 ENOG4105C87 Aminotransferase class I and II E2R47_13130 ENOG4105DFD Na H antiporter E2R47_13135 ENOG41060NJ transcriptional regulator E2R47_13190 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E2R47_13200 ENOG4107SCK Monooxygenase E2R47_13215 ENOG4108I5G Major Facilitator superfamily E2R47_13220 ENOG4105CPQ Dehydrogenase E2R47_13225 ENOG4105C6F GntR Family Transcriptional Regulator E2R47_13240 ENOG4105DPX Hydrogenase, large subunit E2R47_13245 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E2R47_13265 ENOG4105MVP hydrogenase-1 operon protein HyaF E2R47_13290 ENOG4105FFC UPF0187 protein E2R47_13295 ENOG4105M0C cytoplasmic protein E2R47_13305 ENOG4105C26 Dehydrogenase E2R47_13310 ENOG4105EGI Transcriptional regulator E2R47_13325 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes E2R47_13335 ENOG4106DNR multiple antibiotic resistance protein E2R47_13340 ENOG4108594 Permease of the drug metabolite transporter E2R47_13345 ENOG4105E5W Transporter E2R47_13355 ENOG4108YDI single-species biofilm formation on inanimate substrate E2R47_13360 ENOG4108WTK competence damage-inducible protein E2R47_13375 ENOG4105DGW oligopeptidase A E2R47_13380 ENOG4105EMU Dehydrogenase E2R47_13385 ENOG4107XBN GntR Family Transcriptional Regulator E2R47_13390 ENOG41061EV selenium-binding protein YdfZ E2R47_13395 ENOG4105DEI Mannitol dehydrogenase E2R47_13405 ENOG4105CPQ Dehydrogenase E2R47_13425 ENOG4108MK9 spermidine N(1)-acetyltransferase E2R47_13435 ENOG4105KBG Protein of unknown function (DUF1161) E2R47_13440 ENOG4107QY8 reductase E2R47_13445 ENOG4105C3J Cysteine desulfurase E2R47_13450 ENOG4105QAX Iron-sulfur E2R47_13455 ENOG4107KGK dmso reductase anchor subunit E2R47_13460 ENOG4108NEM leader-binding protein dmsD E2R47_13470 ENOG4107QY8 reductase E2R47_13475 ENOG4105QAX Iron-sulfur E2R47_13480 ENOG4107KGK dmso reductase anchor subunit E2R47_13485 ENOG4108NEM leader-binding protein dmsD E2R47_13490 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component E2R47_13495 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E2R47_13500 ENOG4105E90 ABC transporter E2R47_13505 ENOG4108IJ8 ABC transporter E2R47_13510 ENOG4105CMQ Chloride channel E2R47_13515 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E2R47_13520 ENOG4105DAG ROK family E2R47_13525 ENOG4106NZI LysR family Transcriptional regulator E2R47_13530 ENOG4105D94 Major Facilitator Superfamily E2R47_13540 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap E2R47_13560 ENOG4105DSF transport protein E2R47_13565 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E2R47_13570 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E2R47_13575 ENOG4105C5D exported protein E2R47_13580 ENOG4105D5Q Arginine ornithine antiporter E2R47_13585 ENOG4105RA2 Membrane E2R47_13590 ENOG4107EXC regulatoR E2R47_13600 ENOG4105FCK Membrane E2R47_13605 ENOG4105CPN adenine deaminase E2R47_13610 ENOG4105JJR Histidine kinase E2R47_13620 ENOG4105C9Q fumarate hydratase class II E2R47_13625 ENOG4107GFK fumarate E2R47_13630 ENOG4105EIP mannose-6-phosphate isomerase E2R47_13635 ENOG4106J39 exported protein E2R47_13640 ENOG4107P2S Transcriptional regulator E2R47_13645 ENOG4105CI1 PTS System E2R47_13650 ENOG4105C87 Aminotransferase class I and II E2R47_13655 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E2R47_13660 ENOG4105D9R oxidoreductase E2R47_13665 ENOG4106C6R beta-lactam resistance protein E2R47_13675 ENOG4105M9B inner membrane protein ydgK E2R47_13700 ENOG4108UQQ Electron transport complex E2R47_13710 ENOG4105CSM endonuclease III E2R47_13715 ENOG4105DUX Transporter E2R47_13720 ENOG4108K3A Glutathione S-transferase E2R47_13740 ENOG410642K Lysozyme inhibitor E2R47_13750 ENOG4108XTF Outer Membrane Lipoprotein E2R47_13765 ENOG4105Y49 secretion protein, HlyD family E2R47_13770 ENOG4105DSW Fusaric acid resistance protein E2R47_13775 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E2R47_13780 ENOG4107RGM aldo keto reductase E2R47_13785 ENOG4105XZD Fe-S protein E2R47_13790 ENOG4108WUH Transcriptional regulator, TetR family E2R47_13795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E2R47_13800 ENOG4108UYE Lactoylglutathione lyase E2R47_13815 ENOG4105M2J Glutaredoxin E2R47_13820 ENOG4105K4H Nlp p60 protein E2R47_13825 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E2R47_13840 ENOG4105F52 Transcriptional regulator E2R47_13845 ENOG4105CZQ inner membrane transport protein YdhC E2R47_13850 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E2R47_13855 ENOG4108R6K riboflavin synthase, subunit alpha E2R47_13875 ENOG4108IUF type iii secretion E2R47_13880 ENOG4108TN6 type iii secretion E2R47_13885 ENOG41083GP type iii secretion E2R47_13890 ENOG4108HHI Type III secretion system protein E2R47_13895 ENOG41063Q7 Type III secretion system protein E2R47_13910 ENOG4108JIR Flagellum-specific ATP synthase E2R47_13920 ENOG4106H1D secretion system apparatus protein E2R47_13925 ENOG4105UQF type iii secretion E2R47_13930 ENOG4106563 type III secretion system apparatus protein E2R47_13980 ENOG4106FZW pathogenicity island effector protein E2R47_13985 ENOG4108SZ7 secretion system effector E2R47_13995 ENOG4105ZQI secreted protein E2R47_14025 ENOG4105BZU Histidine kinase E2R47_14035 ENOG4108XDN Transcriptional regulator E2R47_14040 ENOG4107SEY Conserved Protein E2R47_14045 ENOG4105RFR Protein of unknown function (DUF2767) E2R47_14050 ENOG4108ZXC Two component transcriptional regulator, luxr family E2R47_14055 ENOG4106AFQ Histidine kinase E2R47_14060 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E2R47_14065 ENOG4106WHD Tetrathionate reductase E2R47_14070 ENOG4105DB1 molybdopterin oxidoreductase E2R47_14075 ENOG4108RVA ribokinase E2R47_14085 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) E2R47_14090 ENOG4105CUB amino acid E2R47_14095 ENOG4105CA9 Pyruvate kinase E2R47_14110 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E2R47_14125 ENOG4105JRK feS assembly protein SufD E2R47_14130 ENOG4105C3K feS assembly ATPase SufC E2R47_14135 ENOG4105DIW FeS assembly protein SUFB E2R47_14140 ENOG4108Z4V iron-sulfur cluster assembly E2R47_14145 ENOG4108ETY sodium dicarboxylate symporter E2R47_14150 ENOG410671Z uncharacterized protein ydiH E2R47_14155 ENOG4105KA0 thioesterase Superfamily protein E2R47_14160 ENOG4105CQB FAD linked oxidase domain protein E2R47_14165 ENOG4105IPI Membrane E2R47_14175 ENOG4105SUA Ydil protein E2R47_14180 ENOG4105EMV Major Facilitator E2R47_14185 ENOG4105EMV Major Facilitator E2R47_14200 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E2R47_14205 ENOG4105C1G acyl-Coa dehydrogenase E2R47_14210 ENOG4105W4W Transcriptional regulator E2R47_14215 ENOG4105CV7 Electron transfer flavoprotein E2R47_14220 ENOG4105C10 Electron transfer flavoprotein E2R47_14225 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E2R47_14230 ENOG41090P5 ferredoxin-like protein E2R47_14235 ENOG4105CEY Amp-dependent synthetase and ligase E2R47_14240 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E2R47_14250 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E2R47_14270 ENOG4106EDX Hemin uptake protein E2R47_14285 ENOG4108QBX (LipO)protein E2R47_14295 ENOG4108V06 Glutathione peroxidase E2R47_14305 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E2R47_14310 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E2R47_14325 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) E2R47_14330 ENOG41082NX 50s ribosomal protein l35 E2R47_14335 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E2R47_14360 ENOG4108NE3 Salt-induced outer membrane protein E2R47_14365 ENOG4105DE4 1-phosphofructokinase E2R47_14370 ENOG4105P10 Uncharacterized protein ydiZ E2R47_14375 ENOG4105FGM Fructosamine kinase E2R47_14380 ENOG4107PN8 YfeABCD locus regulator E2R47_14385 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E2R47_14390 ENOG4107K5X Membrane-bound metal-dependent hydrolase E2R47_14395 ENOG4108ETY sodium dicarboxylate symporter E2R47_14405 ENOG4105CH6 catalase E2R47_14415 ENOG4105F8D glycoside hydrolase family 4 E2R47_14420 ENOG4105EZV Transcriptional regulator E2R47_14425 ENOG4105VCP PTS System E2R47_14430 ENOG4105CK1 PTS System E2R47_14435 ENOG4105VZJ PTS System E2R47_14445 ENOG4105KKI DNA-binding transcriptional activator OsmE E2R47_14455 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) E2R47_14460 ENOG4108SPG Periplasmic Protein E2R47_14470 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) E2R47_14475 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) E2R47_14480 ENOG4105C26 Dehydrogenase E2R47_14495 ENOG4105CGK Exodeoxyribonuclease III E2R47_14500 ENOG4105M6F mutator MutT protein E2R47_14505 ENOG4105MTM Protein of unknown function (DUF1496) E2R47_14510 ENOG4105D82 Glutamate dehydrogenase E2R47_14515 ENOG4108IYH Dna topoisomerase E2R47_14520 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E2R47_14525 ENOG41069NU Nitroreductase E2R47_14530 ENOG4105D07 Signal peptide peptidase, SppA E2R47_14535 ENOG4105HDK L-asparaginase E2R47_14540 ENOG4108RWI nicotinamidase E2R47_14545 ENOG4105VUT cytoplasmic protein E2R47_14555 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E2R47_14565 ENOG4105DSB aldose 1-epimerase E2R47_14570 ENOG4105CV8 reductase E2R47_14575 ENOG4105C4X radical SAM domain protein E2R47_14580 ENOG4105GNX MltA-interacting MipA family protein E2R47_14585 ENOG4105CYN Serine protein kinase E2R47_14600 ENOG4108KHP Diguanylate cyclase E2R47_14605 ENOG4108KXH Ybak prolyl-tRNA synthetase associated E2R47_14620 ENOG4105R1U AraC Family Transcriptional Regulator E2R47_14625 ENOG4105DJ2 Major Facilitator Superfamily E2R47_14630 ENOG4105K78 MarR family Transcriptional regulator E2R47_14640 ENOG4105UCG Domain of unknown function (DUF333) E2R47_14645 ENOG4106G4W E2R47_14650 ENOG4105Y3U Transglycosylase-associated protein E2R47_14665 ENOG4105YP6 Domain of unknown function (DUF1869) E2R47_14670 ENOG4108YS1 cytoplasmic protein E2R47_14685 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E2R47_14695 ENOG4108Z6Z Transcriptional regulator E2R47_14710 ENOG4108MEK Metal-binding protein YodA E2R47_14725 ENOG4105D64 Mechanosensitive ion channel E2R47_14730 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E2R47_14735 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E2R47_14760 ENOG4108VKM cytochrome b561 E2R47_14770 ENOG4108ZNX Heat shock protein E2R47_14800 ENOG4105H38 Membrane E2R47_14820 ENOG41060EU Cold shock-like protein E2R47_14825 ENOG4106F2Y RICIN E2R47_14830 ENOG4105Y50 Virulence Protein E2R47_14835 ENOG4108TMH cytolethal distending toxin E2R47_14870 ENOG4108HMX isocitrate dehydrogenase (NADP) E2R47_14875 ENOG4108R99 pseudouridine synthase E2R47_14900 ENOG4107QTF adenylosuccinate lyase E2R47_14915 ENOG4105EZE Cupin 4 family protein E2R47_14935 ENOG4105F38 ABC transporter, permease E2R47_14945 ENOG4105D38 putrescine abc transporter E2R47_14950 ENOG4107RUE extracellular solute-binding protein family 1 E2R47_14955 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E2R47_14965 ENOG4105D60 lipoprotein releasing system transmembrane protein E2R47_14975 ENOG4105D60 lipoprotein releasing system transmembrane protein E2R47_14980 ENOG4108JA2 transcriptioN-repair coupling factor E2R47_14985 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E2R47_14990 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction E2R47_14995 ENOG4108IND Tetr family transcriptional regulator E2R47_15000 ENOG4107MBR 17 kDa surface antigen E2R47_15005 ENOG4105CEP NADH dehydrogenase E2R47_15025 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) E2R47_15030 ENOG41090DQ Lipoprotein E2R47_15035 ENOG4105K59 histidine triad (HIT) protein E2R47_15040 ENOG4105CNM Receptor E2R47_15045 ENOG4105CI1 PTS System E2R47_15050 ENOG4105F8V Hydrolase, tatD family E2R47_15055 ENOG4107QRG dna polymerase iii E2R47_15065 ENOG4105HHA aminodeoxychorismate lyase E2R47_15070 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E2R47_15075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E2R47_15080 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E2R47_15085 ENOG4105CHR reductase E2R47_15090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E2R47_15110 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E2R47_15115 ENOG4108UHJ MAF-like protein E2R47_15130 ENOG4105EI2 Pseudouridine synthase E2R47_15135 ENOG41071G1 Uncharacterized protein YceQ E2R47_15140 ENOG4107QQB Ribonuclease E E2R47_15150 ENOG4108RS6 transposase E2R47_15165 ENOG4105DTJ flagellar hook-associated protein E2R47_15170 ENOG4105E1Q flagellar hook-associated protein E2R47_15175 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj E2R47_15190 ENOG4105CGA flagellar basal-body rod protein FlgG E2R47_15195 ENOG4108KPB Flagellar basal-body rod protein FlgF E2R47_15200 ENOG4105BZE flagellar hook protein, FlgE E2R47_15205 ENOG4105W00 Flagellar hook capping protein E2R47_15210 ENOG4108ZC9 flagellar basal-body rod protein flgc E2R47_15215 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) E2R47_15225 ENOG4105CKS Flagella basal body P-ring formation protein flgA E2R47_15230 ENOG4105M9M anti-sigma28 factor FlgM E2R47_15235 ENOG4105QVD Flagella synthesis protein FlgN E2R47_15240 ENOG4105CJR Integral membrane protein (MviN E2R47_15245 ENOG4105EP9 oxidoreductase E2R47_15255 ENOG4105D9U N-acetyltransferase E2R47_15265 ENOG4105E9S glutaredoxin 2 E2R47_15270 ENOG4105F3T (LipO)protein E2R47_15280 ENOG4105MEA DNA damage-inducible protein i E2R47_15285 ENOG4105PVA Biofilm formation regulatory protein BssS E2R47_15295 ENOG4106974 biofilm formation E2R47_15300 ENOG4105DS1 cytochrome b561 E2R47_15305 ENOG4108YYC ycei family E2R47_15310 ENOG4105C72 UPF0176 protein E2R47_15315 ENOG4105D1S lipid A biosynthesis E2R47_15330 ENOG4108W47 Acidic protein msyB E2R47_15335 ENOG4105NAC (LipO)protein E2R47_15340 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) E2R47_15360 ENOG4107RZC phospholipase d E2R47_15365 ENOG4108UVJ appr-1-p processing domain protein E2R47_15390 ENOG41086KC Transcriptional regulator E2R47_15395 ENOG4108XDW curli assembly protein CsgE E2R47_15400 ENOG4108WYR Curli production assembly transport component, CsgF E2R47_15405 ENOG4105P8Q Curli production assembly transport component CsgG E2R47_15410 ENOG4108UQ5 membrane protein YcdZ E2R47_15415 ENOG4107XHZ cytoplasmic chaperone TorD family protein E2R47_15445 ENOG4107RJ5 oxidoreductase E2R47_15450 ENOG4105JHE Major Facilitator Superfamily E2R47_15455 ENOG4108QGT oligogalacturonate-specific porin E2R47_15465 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E2R47_15470 ENOG4107RJ1 sodium solute E2R47_15475 ENOG4105QEK Transcriptional regulator E2R47_15480 ENOG4105D5M phosphate starvation-inducible protein E2R47_15490 ENOG4105CK7 Sodium proline symporter E2R47_15505 ENOG4108R86 Transcriptional regulator E2R47_15510 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 E2R47_15520 ENOG4105XH3 E2R47_15525 ENOG4105D6F Phosphatase E2R47_15530 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E2R47_15535 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E2R47_15540 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E2R47_15605 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase E2R47_15610 ENOG4105C26 Dehydrogenase E2R47_15620 ENOG4108V8F Transcriptional regulator, MarR family E2R47_15625 ENOG4105EFA 4-hydroxyphenylacetate E2R47_15630 ENOG4107UWN reductase E2R47_15640 ENOG4105VT2 5-hydroxyisourate hydrolase E2R47_15645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E2R47_15650 ENOG4107ZY3 Histidine kinase E2R47_15665 ENOG4106YSC E2R47_15670 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell E2R47_15685 ENOG41084BJ Pentapeptide repeat protein E2R47_15700 ENOG4108MN8 Membrane E2R47_15710 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E2R47_15720 ENOG4108V1U phospholipid-binding protein E2R47_15735 ENOG4105K4P CoA-binding domain protein E2R47_15750 ENOG41088T4 Helicase IV E2R47_15755 ENOG410901E Membrane E2R47_15760 ENOG4105EM2 membrane E2R47_15765 ENOG4108RZ1 DNA transformation protein E2R47_15775 ENOG4105UYK outer membrane protein a E2R47_15785 ENOG4105DAN ATP-dependent protease E2R47_15795 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) E2R47_15800 ENOG4108Q2G (LipO)protein E2R47_15805 ENOG4105DY2 Paraquat-inducible protein b E2R47_15810 ENOG4105F1S paraquat-inducible protein a E2R47_15815 ENOG4105C5H ABC transporter E2R47_15825 ENOG4105QVC MOSC domain-containing protein E2R47_15830 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) E2R47_15840 ENOG4105CD8 aminopeptidase N E2R47_15855 ENOG4107RCH Diaminopropionate ammonia-lyase E2R47_15870 ENOG4105C5S asparaginyl-tRNA synthetase E2R47_15875 ENOG4105FCK Membrane E2R47_15880 ENOG4105CGF Aromatic amino acid aminotransferase E2R47_15885 ENOG4105C5X domain protein E2R47_15890 ENOG4105EAQ (twin-arginine translocation) pathway signal E2R47_15895 ENOG4105DIT ErfK YbiS YcfS YnhG family protein E2R47_15910 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) E2R47_15920 ENOG4106371 Methyltransferase E2R47_15925 ENOG4107S90 membrAne E2R47_15930 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups E2R47_15945 ENOG4105T0Z Conserved Protein E2R47_15960 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E2R47_15965 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E2R47_15970 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E2R47_15980 ENOG4108K0D peptidase, M48 E2R47_15995 ENOG4107VMU Membrane E2R47_16000 ENOG4105DDY UPF0142 protein ycaO E2R47_16005 ENOG4105TMB Formate nitrite transporter E2R47_16010 ENOG4105C6N Formate acetyltransferase E2R47_16015 ENOG4105GUS E2R47_16025 ENOG4105F1A Pyruvate formate-lyase E2R47_16030 ENOG4105E5D amino acid E2R47_16040 ENOG4107KGK dmso reductase anchor subunit E2R47_16045 ENOG4105QAX Iron-sulfur E2R47_16050 ENOG4107QY8 reductase E2R47_16060 ENOG4105D1H recombination factor protein RarA E2R47_16070 ENOG4105CNU cell division protein FtsK E2R47_16075 ENOG4105EW9 transcriptional regulator AsnC family E2R47_16080 ENOG4105C3M thioredoxin reductase E2R47_16085 ENOG4108JJ9 ABC, transporter E2R47_16090 ENOG4108JJ8 (ABC) transporter E2R47_16105 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E2R47_16110 ENOG4105HEI LysR family (Transcriptional regulator E2R47_16115 ENOG4105EUB pirin domain protein E2R47_16120 ENOG4105CHJ isochorismatase hydrolase E2R47_16165 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E2R47_16175 ENOG4105VEQ Cold shock protein E2R47_16180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E2R47_16185 ENOG4105DJY efflux transporter, rnd family, mfp subunit E2R47_16190 ENOG4108MJ5 VirK protein E2R47_16195 ENOG4105CPB ATP-dependent endonuclease of the OLD family E2R47_16200 ENOG4105DWU Membrane E2R47_16210 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E2R47_16215 ENOG4105C7K acetolactate synthase E2R47_16220 ENOG4105C5W Aldolase E2R47_16225 ENOG4105CGD Nad-dependent epimerase dehydratase E2R47_16230 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase E2R47_16235 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E2R47_16245 ENOG41064MM (LipO)protein E2R47_16250 ENOG4105E5Z arginine transporter ATP-binding subunit E2R47_16255 ENOG4106PMH Extracellular solute-binding protein family 3 E2R47_16260 ENOG4105GBT ABC transporter E2R47_16265 ENOG4105DMR ABC, transporter E2R47_16270 ENOG4106TNF Periplasmic binding protein E2R47_16295 ENOG4105RBQ inner membrane protein ybjO E2R47_16300 ENOG4105D38 putrescine abc transporter E2R47_16305 ENOG4105F38 ABC transporter, permease E2R47_16310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E2R47_16315 ENOG4107RUE extracellular solute-binding protein family 1 E2R47_16320 ENOG4108RMJ sensory transduction regulator E2R47_16330 ENOG4108DBC nitroreductase E2R47_16335 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress E2R47_16340 ENOG41090BQ Glutaredoxin E2R47_16345 ENOG4105GWF inner membrane protein YbjM E2R47_16360 ENOG4108RFG Tetr family transcriptional regulator E2R47_16365 ENOG4106UW1 Major Facilitator superfamily E2R47_16370 ENOG4108HCJ Hydrolase E2R47_16375 ENOG4107QF7 multi-drug E2R47_16380 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E2R47_16385 ENOG4107FB0 transcriptional regulator DeoR family E2R47_16390 ENOG4105DZ1 carboxypeptidase E2R47_16395 ENOG4108TGY Glutathione S-transferase E2R47_16400 ENOG4105D8V Glucose sorbosone dehydrogenase E2R47_16405 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway E2R47_16420 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E2R47_16425 ENOG4105DEF Extracellular solute-binding protein, family 5 E2R47_16430 ENOG4108JQ6 ABC transporter E2R47_16435 ENOG4105D44 asparaginase E2R47_16440 ENOG4105CVM Molybdenum cofactor synthesis domain protein E2R47_16445 ENOG4105D06 uba thif-type nad fad binding protein E2R47_16450 ENOG4105F1A Pyruvate formate-lyase E2R47_16455 ENOG4105C6N Formate acetyltransferase E2R47_16460 ENOG4108HCJ Hydrolase E2R47_16465 ENOG41072TH Protein of unknown function (DUF1479) E2R47_16470 ENOG4105C5H ABC transporter E2R47_16475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E2R47_16480 ENOG4105F4P )-transporter E2R47_16485 ENOG4105KST dependent repressor E2R47_16495 ENOG4108I6E Sulfatase E2R47_16500 ENOG4108T1M outer membrane protein x E2R47_16515 ENOG4107R0W ABC transporter E2R47_16520 ENOG4105E5Q amino acid AbC transporter E2R47_16525 ENOG4105CDA abc transporter atp-binding protein E2R47_16530 ENOG4105D8X mechanosensitive ion channel E2R47_16540 ENOG4105KSC Transcriptional regulator, TraR DksA family E2R47_16545 ENOG4105VR4 UPF0379 protein ybiJ E2R47_16550 ENOG4108MTB glycosyl transferase family E2R47_16555 ENOG4105DVT helicase E2R47_16560 ENOG4105C1J atp-dependent rna helicase E2R47_16565 ENOG4107MVR Transcriptional regulator E2R47_16575 ENOG4105CJ1 ABC, transporter E2R47_16580 ENOG4107QWP ABC-2 type transporter E2R47_16585 ENOG4107QWP ABC-2 type transporter E2R47_16590 ENOG4105I9U inner membrane protein ybhQ E2R47_16595 ENOG4105X23 Endonuclease Exonuclease phosphatase E2R47_16600 ENOG4105DZQ phospholipase D Transphosphatidylase E2R47_16605 ENOG4107UXM Membrane E2R47_16625 ENOG4105HFZ Membrane E2R47_16630 ENOG4108ZAF Molybdopterin E2R47_16635 ENOG4105M00 molybdopterin converting factor, subunit 1 E2R47_16645 ENOG4108RIR Molybdenum cofactor biosynthesis protein E2R47_16655 ENOG4105CHW UPF0052 protein E2R47_16680 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E2R47_16685 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E2R47_16700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E2R47_16705 ENOG4108V1U phospholipid-binding protein E2R47_16735 ENOG4105NBR Pectinesterase E2R47_16745 ENOG4108K4B hydrolase E2R47_16755 ENOG4105E0C molybdate abc transporter E2R47_16760 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E2R47_16765 ENOG410680R Protein of unknown function (DUF2592) E2R47_16770 ENOG4105F4R Transcriptional regulator mode E2R47_16775 ENOG4105DKW ABC transporter E2R47_16785 ENOG4105CMR udp-glucose 4-epimerase E2R47_16790 ENOG4105F0Z galactose-1-phosphate uridylyltransferase E2R47_16800 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E2R47_16810 ENOG4105E0A ABC, transporter E2R47_16815 ENOG4105EHG Permease protein E2R47_16820 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E2R47_16825 ENOG4105D9Q decarboxylase (Beta subunit) E2R47_16830 ENOG4107QSA Oxaloacetate decarboxylase E2R47_16840 ENOG4107QWE )-transporter E2R47_16850 ENOG4105C5Q Transcriptional regulator E2R47_16855 ENOG4106DSS Tartrate dehydratase subunit alpha E2R47_16860 ENOG4107GFK fumarate E2R47_16865 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E2R47_16870 ENOG4105JND homeobox protein E2R47_16875 ENOG4105PGM cation diffusion facilitator family transporter E2R47_16880 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E2R47_16915 ENOG4105UFD tol-pal system protein YbgF E2R47_16920 ENOG4105KCK Peptidoglycan-associated lipoprotein E2R47_16930 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA E2R47_16935 ENOG4105M8F Biopolymer transport protein exbD tolR E2R47_16940 ENOG4105E02 MotA TolQ exbB proton channel E2R47_16945 ENOG4107YD3 Thioesterase E2R47_16950 ENOG4105KJB cyd operon protein YbgE E2R47_16960 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E2R47_16965 ENOG4105C4M (Ubiquinol oxidase) subunit I E2R47_16970 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E2R47_16980 ENOG4105C7S Dehydrogenase E2R47_16985 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E2R47_16990 ENOG4105E33 succinate dehydrogenase E2R47_16995 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E2R47_17000 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E2R47_17005 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E2R47_17010 ENOG4105BZN citrate synthase E2R47_17015 ENOG4108KK1 membrane protein AbrB duplication E2R47_17030 ENOG4107R7A Allophanate hydrolase subunit 2 E2R47_17035 ENOG4105P4J Allophanate hydrolase, subunit 1 E2R47_17040 ENOG4107QNR UPF0135 protein E2R47_17055 ENOG4105CVP deoxyribo-dipyrimidine photolyase E2R47_17060 ENOG4105XIQ Protein of unknown function (DUF2517) E2R47_17085 ENOG4105C08 Histidine kinase E2R47_17090 ENOG4105EEX Two component transcriptional regulator (Winged helix family E2R47_17100 ENOG4105CXN decarboxylase E2R47_17105 ENOG4105D5Q Arginine ornithine antiporter E2R47_17115 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 E2R47_17120 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) E2R47_17125 ENOG4105EV9 Alpha Beta Hydrolase E2R47_17130 ENOG4105NNH LexA regulated protein E2R47_17135 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) E2R47_17140 ENOG41090R7 Ferric uptake E2R47_17145 ENOG4106P55 Transcriptional regulator E2R47_17150 ENOG4107EFR Flavocytochrome c E2R47_17155 ENOG41079YP Citrate utilization protein b E2R47_17160 ENOG4105CSH Transporter E2R47_17165 ENOG4105GX6 (LipO)protein E2R47_17170 ENOG4105J5J Outer membrane porin E2R47_17180 ENOG4105CI1 PTS System E2R47_17190 ENOG4105CE4 GlcNAc 6-P deacetylase E2R47_17195 ENOG4105E2R ROK family E2R47_17200 ENOG4105D4U had-superfamily hydrolase, subfamily iia E2R47_17205 ENOG4105CAQ asparagine synthetase E2R47_17250 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E2R47_17260 ENOG4105C9A Phoh family E2R47_17270 ENOG4108JU5 Magnesium and cobalt efflux protein E2R47_17275 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E2R47_17280 ENOG4107RP9 extracellular solute-binding protein, family 3 E2R47_17285 ENOG4105EAD ABC transporter E2R47_17290 ENOG4105DRP amino acid AbC transporter E2R47_17295 ENOG4105CDA abc transporter atp-binding protein E2R47_17310 ENOG4105F7F Chaperone E2R47_17315 ENOG4105QFC Hsc56 co-chaperone of HscC E2R47_17320 ENOG41069CF Protein of unknown function (DUF1266) E2R47_17325 ENOG4105QFC Hsc56 co-chaperone of HscC E2R47_17330 ENOG41069CF Protein of unknown function (DUF1266) E2R47_17340 ENOG4107PAI alpha helical protein E2R47_17345 ENOG4108JUB Transcriptional regulator E2R47_17350 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E2R47_17375 ENOG4105DJF DNA polymerase III, delta' subunit E2R47_17380 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) E2R47_17385 ENOG4107QZB decarboxylase E2R47_17390 ENOG4108TGR phosphatase E2R47_17395 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E2R47_17405 ENOG4105CJN penicillin-binding protein E2R47_17410 ENOG4105CNI cell division protein FtsW E2R47_17415 ENOG4105K6T rare lipoprotein A E2R47_17420 ENOG4105DZ1 carboxypeptidase E2R47_17425 ENOG4108Z43 UPF0250 protein E2R47_17435 ENOG41064T2 transcriptional regulator, lysR family E2R47_17450 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E2R47_17460 ENOG4105VEQ Cold shock protein E2R47_17470 ENOG4105CEE C4-dicarboxylate transporter E2R47_17475 ENOG4106YYS transcriptional regulatory protein E2R47_17480 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E2R47_17485 ENOG4105DUA (citrate (pro-3S)-lyase ligase E2R47_17490 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) E2R47_17495 ENOG4105CI0 Citrate lyase E2R47_17500 ENOG4105CHY citrate lyase, alpha E2R47_17505 ENOG4105YGP holo-ACP synthase CitX E2R47_17510 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E2R47_17515 ENOG4107QPK )-transporter E2R47_17520 ENOG4105KTS ribonuclease E2R47_17525 ENOG4105NXH GreA GreB family elongation factor E2R47_17530 ENOG4105E2A Dehydrogenase E2R47_17535 ENOG4108U51 Universal stress protein E2R47_17545 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E2R47_17550 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E2R47_17560 ENOG4108JU3 Alkyl hydroperoxide reductase E2R47_17565 ENOG4105D3R alkyl hydroperoxide reductase E2R47_17570 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E2R47_17580 ENOG4105DQS Transcriptional regulator E2R47_17585 ENOG4105BZV Phosphoadenosine phosphosulfate reductase E2R47_17590 ENOG4105GTN ParB Domain Protein Nuclease E2R47_17595 ENOG4105CHM Aminotransferase E2R47_17600 ENOG4107SCQ Iron-containing alcohol dehydrogenase E2R47_17605 ENOG4105VCD cytoplasmic protein E2R47_17610 ENOG4105D22 carbon starvation protein E2R47_17620 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E2R47_17625 ENOG4105WQI isochorismatase E2R47_17630 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E2R47_17635 ENOG4105E4F Isochorismate synthase E2R47_17640 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein E2R47_17645 ENOG4105E8G Major facilitator Superfamily E2R47_17650 ENOG4105DQ5 transport system permease protein E2R47_17655 ENOG4105TVJ transport system, permease E2R47_17660 ENOG4105E0A ABC, transporter E2R47_17665 ENOG4108QY5 Ferric enterobactin transport protein E2R47_17670 ENOG4105C0W non-ribosomal peptide synthetase E2R47_17675 ENOG41085A6 mbth domain-containing protein E2R47_17680 ENOG4105E93 esterase E2R47_17685 ENOG4107RNH Outer membrane receptor FepA E2R47_17690 ENOG4108TSE Transferase E2R47_17695 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) E2R47_17700 ENOG4105WQ6 Membrane E2R47_17705 ENOG4105HFT AraC family transcriptional regulator E2R47_17710 ENOG41067SE Tetr family transcriptional regulator E2R47_17715 ENOG4105MSB protein, conserved in bacteria E2R47_17720 ENOG4108RCM Nitroreductase E2R47_17730 ENOG4105CUY Mechanosensitive ion channel E2R47_17735 ENOG4105C85 amino acid E2R47_17745 ENOG4108KBJ Inner membrane protein YkgB E2R47_17750 ENOG41066GK UPF0379 protein ykgI E2R47_17755 ENOG4107QN2 dihydrolipoyl dehydrogenase E2R47_17760 ENOG4108K01 transcriptional regulator E2R47_17765 ENOG4108IJF Heavy metal efflux pump, CzcA E2R47_17770 ENOG4105GR3 Histidine kinase E2R47_17780 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E2R47_17785 ENOG4105CKK Glycosyl transferase, family 2 E2R47_17820 ENOG4106KCD HTH_LUXR E2R47_17830 ENOG4106721 fimbriae Y protein E2R47_17835 ENOG4108Q9V regulatoR E2R47_17840 ENOG4108ZI2 Fimbrial protein E2R47_17845 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) E2R47_17850 ENOG4105CW0 outer membrane usher protein E2R47_17855 ENOG4108AF8 Chaperone E2R47_17865 ENOG4108WDE Fimbrial protein E2R47_17880 ENOG4105WQ3 Rna-binding protein E2R47_17885 ENOG4105S2T inner membrane protein YbcI E2R47_17905 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E2R47_17915 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E2R47_17920 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E2R47_17930 ENOG4108UMI ABC transporter, permease E2R47_17935 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E2R47_17940 ENOG4105D01 (LipO)protein E2R47_17950 ENOG4105CV6 ABC transporter, permease E2R47_17955 ENOG4108I0Y (ABC) transporter E2R47_17960 ENOG4108UJV acyl-CoA thioesterase i E2R47_17965 ENOG4105E1F short-chain dehydrogenase reductase E2R47_17970 ENOG4107QR8 Thioredoxin E2R47_17975 ENOG4105C4B ABC transporter, permease E2R47_17980 ENOG41083J0 (ABC) transporter E2R47_17985 ENOG4107QX8 SPFH domain, Band 7 family protein E2R47_17990 ENOG4105G5H Membrane E2R47_17995 ENOG4108Z6Z Transcriptional regulator E2R47_18000 ENOG4105C59 p-type ATPase E2R47_18010 ENOG4105MBR gumn family E2R47_18015 ENOG4108Z66 YbaK ebsC protein E2R47_18020 ENOG4105CGH 5'-nucleotidase E2R47_18025 ENOG4105EU0 Major facilitator Superfamily E2R47_18030 ENOG4105CKD glutathione-regulated potassium-efflux system protein E2R47_18035 ENOG4107RE1 Inosine-guanosine kinase E2R47_18040 ENOG4105F2M alpha beta hydrolase fold-3 domain protein E2R47_18075 ENOG4107QMP dna polymerase iii subunits gamma and tau E2R47_18085 ENOG4105WD1 Membrane E2R47_18090 ENOG4108URS primosomal replication protein n'' E2R47_18095 ENOG4106428 Protein of unknown function (DUF2496) E2R47_18100 ENOG4105DNE Transposase E2R47_18105 ENOG4105EGS Mechanosensitive ion channel E2R47_18110 ENOG4108IG5 Transcriptional regulator E2R47_18115 ENOG4105C1P efflux transporter, rnd family, mfp subunit E2R47_18120 ENOG4105BZS acriflavin resistance protein E2R47_18125 ENOG4108UKR Biofilm formation regulator YbaJ E2R47_18135 ENOG4108UW5 maltose o-acetyltransferase E2R47_18140 ENOG4105GSJ Inner membrane protein ylaC E2R47_18155 ENOG41066DG (EAL) domain protein E2R47_18165 ENOG41080UX Methyltransferase E2R47_18170 ENOG4108MNP Glycoprotein polysaccharide metabolism E2R47_18175 ENOG4105C29 acyl-CoA thioesterase E2R47_18180 ENOG4105BZU Histidine kinase E2R47_18185 ENOG4108YZA Nitrogen regulatory protein pii E2R47_18190 ENOG4105BZ1 (ABC) transporter E2R47_18195 ENOG4105BZ1 (ABC) transporter E2R47_18200 ENOG4108XM1 transcriptional regulator AsnC family E2R47_18210 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) E2R47_18215 ENOG4108NFA extracellular solute-binding protein E2R47_18225 ENOG4108TGP Thioesterase superfamily protein E2R47_18230 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E2R47_18235 ENOG4105EIN peptidylprolyl cis-trans isomerase E2R47_18240 ENOG4105K70 DNA-binding protein E2R47_18245 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) E2R47_18270 ENOG4105M85 Bola protein E2R47_18275 ENOG4105IEY (LipO)protein E2R47_18280 ENOG4105EYM Major Facilitator superfamily E2R47_18285 ENOG4105E2S oxidase) subunit II E2R47_18290 ENOG4105BZ9 Cytochrome C oxidase, subunit I E2R47_18295 ENOG4105CCU oxidase (Subunit III) E2R47_18300 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E2R47_18325 ENOG4107RDB Major Facilitator E2R47_18335 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E2R47_18340 ENOG4107S0N DJ-1 family E2R47_18355 ENOG4106S9K Transcriptional regulator E2R47_18365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E2R47_18370 ENOG4108MP3 ABC transporter, permease E2R47_18375 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component E2R47_18390 ENOG4105CTB Polyprenyl synthetase E2R47_18400 ENOG4105CPC Aldo Keto reductase E2R47_18405 ENOG4108ZAI phosphatidylglycerophosphatase a E2R47_18410 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E2R47_18415 ENOG4107YIM Involved in the transcription termination process (By similarity) E2R47_18425 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E2R47_18435 ENOG4108KIC (LipO)protein E2R47_18440 ENOG4105DRB nucleoside-specific channel-forming protein E2R47_18455 ENOG4105N1F Hnh endonuclease E2R47_18470 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E2R47_18480 ENOG4105VIE preprotein translocase, subunit YajC E2R47_18500 ENOG4105D3R alkyl hydroperoxide reductase E2R47_18510 ENOG4107R28 alpha amylase, catalytic region E2R47_18515 ENOG4105C85 amino acid E2R47_18520 ENOG4105CWM branched-chain amino acid transport system II carrier protein E2R47_18525 ENOG4105BZU Histidine kinase E2R47_18530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E2R47_18535 ENOG4107RH8 nuclease SbcCD subunit D E2R47_18540 ENOG4105EYH Exonuclease E2R47_18545 ENOG4105F27 Major Facilitator E2R47_18550 ENOG4105DKQ ROK family E2R47_18565 ENOG4105HBA AroM protein E2R47_18570 ENOG4105SS3 E2R47_18585 ENOG4105II7 pyrroline-5-carboxylate reductase E2R47_18590 ENOG4105BZU Histidine kinase E2R47_18595 ENOG4105VIF phosphate starvation-inducible protein E2R47_18615 ENOG4105CPF Cell wall formation (By similarity) E2R47_18620 ENOG4105UNH Membrane E2R47_18625 ENOG4105FR5 inner membrane protein YaiY E2R47_18630 ENOG4107QS8 (LipO)protein E2R47_18635 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 E2R47_18645 ENOG4107R6D beta-lactam binding protein AmpH E2R47_18650 ENOG4108PNB DNA-binding transcriptional regulator E2R47_18655 ENOG4108NSE outer membrane autotransporter barrel E2R47_18660 ENOG4105D52 delta-aminolevulinic acid dehydratase E2R47_18665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E2R47_18670 ENOG4105DXD 2-methylcitrate dehydratase E2R47_18675 ENOG4105BZN citrate synthase E2R47_18680 ENOG4105CR4 methylisocitrate lyase E2R47_18685 ENOG4108JU7 Transcriptional regulator E2R47_18690 ENOG4105TDT uncharacterized protein yahO E2R47_18695 ENOG4105E82 cytochrome subunit of dehydrogenase E2R47_18715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E2R47_18720 ENOG4105C4M (Ubiquinol oxidase) subunit I E2R47_18730 ENOG4105D8D Type III E2R47_18735 ENOG4107QMH DNA methylase E2R47_18740 ENOG4105JHE Major Facilitator Superfamily E2R47_18770 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E2R47_18790 ENOG4108T1M outer membrane protein x E2R47_18805 ENOG4105CXC rtn protein E2R47_18820 ENOG4105X0I Fimbrial E2R47_18825 ENOG4108VEV chaperone E2R47_18830 ENOG4105CW0 outer membrane usher protein E2R47_18855 ENOG4105EJC lysr family transcriptional regulator E2R47_18865 ENOG4105ERH Fumarylacetoacetate hydrolase E2R47_18870 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E2R47_18875 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E2R47_18880 ENOG4105D94 Major Facilitator Superfamily E2R47_18885 ENOG4105V2F Uncharacterized protein yoac E2R47_18890 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E2R47_18895 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E2R47_18925 ENOG4105FCK Membrane E2R47_18945 ENOG4105CIN aminoacyl-histidine dipeptidase E2R47_18950 ENOG4108S2Y peptide Chain Release factor E2R47_18965 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E2R47_18970 ENOG4105E7A Glutamine amidotransferase E2R47_18980 ENOG4107QPN acyl-Coa dehydrogenase E2R47_18985 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E2R47_18995 ENOG4105T40 surface antigen msp4 family protein E2R47_19005 ENOG4105W7K Transcriptional regulator E2R47_19075 ENOG4105CNA YD repeat protein E2R47_19090 ENOG4105CNA YD repeat protein E2R47_19100 ENOG4105CS6 Rhs element vgr protein E2R47_19190 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E2R47_19230 ENOG4108JDX DNA polymerase iii, epsilon subunit E2R47_19240 ENOG4105D1A Methyltransferase E2R47_19250 ENOG4105E9H Lytic Murein transglycosylase E2R47_19255 ENOG4105F2W methyltransferase E2R47_19265 ENOG4105F27 Major Facilitator E2R47_19270 ENOG4105HEI LysR family (Transcriptional regulator E2R47_19275 ENOG4105CV8 reductase E2R47_19310 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E2R47_19320 ENOG4108UMI ABC transporter, permease E2R47_19325 ENOG4105D01 (LipO)protein E2R47_19330 ENOG4108R8X outer membrane lipoprotein E2R47_19335 ENOG4108R96 Methyltransferase, YaeB family E2R47_19345 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion E2R47_19350 ENOG4108YZN class I peptide chain release factor E2R47_19355 ENOG4108VWS Yaeq family E2R47_19365 ENOG4105M1T rho-binding antiterminator E2R47_19375 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase E2R47_19380 ENOG4105CXN decarboxylase E2R47_19385 ENOG4108M1A Chitin-binding protein E2R47_19395 ENOG4105C0B DNA polymerase III (alpha subunit) E2R47_19440 ENOG4105KNE Phosphatidate cytidylyltransferase E2R47_19480 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E2R47_19495 ENOG4105CSH Transporter E2R47_19505 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E2R47_19510 ENOG4105C0H protease E2R47_19525 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E2R47_19530 ENOG4105EN6 Membrane E2R47_19550 ENOG4106RDH Protein of unknown function (DUF2544) E2R47_19560 ENOG4105UGQ Fimbrial E2R47_19565 ENOG4105NEV Fimbrial E2R47_19570 ENOG4108FZ9 Chaperone E2R47_19575 ENOG4106PG1 outer membrane usher protein E2R47_19590 ENOG4105S6R Iron-hydroxamate transporter permease subunit E2R47_19595 ENOG4105J76 Periplasmic binding protein E2R47_19600 ENOG4105E0A ABC, transporter E2R47_19605 ENOG4105E0K tonB-dependent siderophore receptor E2R47_19610 ENOG4105BZ4 penicillin-binding protein E2R47_19615 ENOG4105CQ7 ATP-dependent helicase E2R47_19620 ENOG4107XID 2'-5' rna ligase E2R47_19630 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E2R47_19640 ENOG4105DJ0 Poly(A) Polymerase E2R47_19645 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E2R47_19665 ENOG4107BJW polysaccharide deacetylase E2R47_19670 ENOG4108YTN IIa component E2R47_19680 ENOG4108UIF Chaperone E2R47_19685 ENOG4105CW0 outer membrane usher protein E2R47_19690 ENOG4108MDY Fimbrial E2R47_19695 ENOG4105E3A (ABC) transporter E2R47_19700 ENOG4105DA5 (ABC) transporter E2R47_19705 ENOG41077A9 carbonic anhydrase E2R47_19710 ENOG4108UGV hypoxanthine phosphoribosyltransferase E2R47_19715 ENOG4105DZG Dehydrogenase E2R47_19720 ENOG4105E3B Multicopper oxidase E2R47_19725 ENOG4108ZRK uncharacterized protein yacC E2R47_19740 ENOG4105MVE transcriptional regulator E2R47_19745 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E2R47_19750 ENOG4107S2N Type III effector Hrp-dependent E2R47_19755 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E2R47_19770 ENOG4106HGK Inner membrane protein yieI E2R47_19775 ENOG4107QIJ Aconitate hydratase 2 E2R47_19780 ENOG4108NST exported protein E2R47_19795 ENOG4107QN2 dihydrolipoyl dehydrogenase E2R47_19800 ENOG4107QSN dihydrolipoamide acetyltransferase E2R47_19805 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E2R47_19810 ENOG41073TP transcriptional regulator E2R47_19815 ENOG4105C85 amino acid E2R47_19820 ENOG4105CT4 transporter E2R47_19825 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) E2R47_19830 ENOG4106A72 regulatory protein AmpE E2R47_19840 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E2R47_19850 ENOG4108ZUW Major pilin subunit E2R47_19855 ENOG4107QHF type ii secretion system protein e E2R47_19860 ENOG4105D7Q type ii secretion system E2R47_19870 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E2R47_19885 ENOG410642W LysR family Transcriptional regulator E2R47_19890 ENOG4108FN7 Aldo keto reductase E2R47_19895 ENOG4105M6F mutator MutT protein E2R47_19915 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E2R47_19920 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E2R47_19925 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E2R47_19930 ENOG4105CPF Cell wall formation (By similarity) E2R47_19945 ENOG4105CNI cell division protein FtsW E2R47_19960 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E2R47_19965 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E2R47_19970 ENOG4105CJN penicillin-binding protein E2R47_19975 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E2R47_19990 ENOG4107B7Y DNA-binding transcriptional regulator FruR E2R47_19995 ENOG4108ZP8 Acetolactate synthase small subunit E2R47_20000 ENOG4105C7K acetolactate synthase E2R47_20005 ENOG41064T2 transcriptional regulator, lysR family E2R47_20030 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E2R47_20045 ENOG4105DP9 ABC transporter E2R47_20050 ENOG4106SMU thiamine transporter membrane protein E2R47_20055 ENOG4107T0D ABC, transporter E2R47_20060 ENOG4108KF1 Membrane E2R47_20065 ENOG41063TF transcriptional regulator (AraC E2R47_20080 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E2R47_20100 ENOG4105CQ2 DNA polymerase E2R47_20110 ENOG4105D3G Pseudouridine synthase E2R47_20120 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E2R47_20130 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E2R47_20180 ENOG4105M5B (LipO)protein E2R47_20185 ENOG4105C54 Major Facilitator superfamily E2R47_20190 ENOG4105WQV ferredoxin-like protein E2R47_20195 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E2R47_20240 ENOG4108XNW Transcriptional activatory protein CaiF E2R47_20245 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E2R47_20250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E2R47_20280 ENOG4105CHY citrate lyase, alpha E2R47_20285 ENOG4105CI0 Citrate lyase E2R47_20295 ENOG4105DUA (citrate (pro-3S)-lyase ligase E2R47_20310 ENOG4107QSA Oxaloacetate decarboxylase E2R47_20315 ENOG4105D9Q decarboxylase (Beta subunit) E2R47_20320 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E2R47_20325 ENOG4106YYS transcriptional regulatory protein E2R47_20345 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E2R47_20360 ENOG4105DTN riboflavin biosynthesis protein ribF E2R47_20365 ENOG410647N response to DNA damage stimulus E2R47_20385 ENOG41063Z6 transcriptional regulator, lysR family E2R47_20405 ENOG4105C4X radical SAM domain protein E2R47_20410 ENOG41061MV Arylsulfatase E2R47_20420 ENOG4105CGH 5'-nucleotidase E2R47_20435 ENOG4105DQS Transcriptional regulator E2R47_20455 ENOG4106PH7 chaperone E2R47_20470 ENOG4105MHR Fimbrial protein E2R47_20475 ENOG4105CW0 outer membrane usher protein E2R47_20480 ENOG4108AF8 Chaperone E2R47_20540 ENOG4108QUJ UPF0174 protein YaaW E2R47_20545 ENOG4106HK8 GPR1 FUN34 yaaH family protein E2R47_20550 ENOG4108RIR Molybdenum cofactor biosynthesis protein E2R47_20560 ENOG4105BZG amino acid carrier protein E2R47_20570 ENOG4105D98 threonine synthase E2R47_20580 ENOG4105CFH Aspartokinase E2R47_20590 ENOG4106FVC RNA methyltransferase E2R47_20595 ENOG410759A E2R47_20600 ENOG41065U4 response regulator E2R47_20610 ENOG4108PNB DNA-binding transcriptional regulator E2R47_20620 ENOG4108VCD Chaperone E2R47_20625 ENOG4105CW0 outer membrane usher protein E2R47_20640 ENOG4105CT7 inner membrane cred family protein E2R47_20645 ENOG4105EB3 Histidine kinase E2R47_20650 ENOG4105E3W Two component transcriptional regulator (Winged helix family E2R47_20655 ENOG4108RH0 Crea protein E2R47_20660 ENOG4105UEI Transcriptional Regulator AraC Family E2R47_20685 ENOG4107SC1 transglycosylase E2R47_20690 ENOG4105C5H ABC transporter E2R47_20695 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase E2R47_20700 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E2R47_20705 ENOG4105EAC phosphoserine phosphatase E2R47_20715 ENOG41062Z9 Membrane E2R47_20725 ENOG4108UK5 Transposase E2R47_20750 ENOG4105G0K glycine radical enzyme YjjI family E2R47_20755 ENOG41076CZ activating enzyme E2R47_20760 ENOG4105EYA deoxyribonuclease E2R47_20765 ENOG4108NRW Phospholipase, patatin family E2R47_20775 ENOG4105K3G Periplasmic Protein E2R47_20785 ENOG4105PAD Hydrolase E2R47_20790 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E2R47_20795 ENOG4108WPU DNA polymerase III subunit psi E2R47_20820 ENOG4105YBH Protein of unknown function (DUF1435) E2R47_20825 ENOG4105BZU Histidine kinase E2R47_20830 ENOG4108819 ferric iron reductase E2R47_20835 ENOG4108UIN ybak prolyl-trna synthetase associated region E2R47_20840 ENOG4108T94 DNA-binding transcriptional activator BglJ E2R47_20845 ENOG4108N8T regulatoR E2R47_20850 ENOG4105DWK Membrane E2R47_20865 ENOG4106CVF DNA replication protein E2R47_20870 ENOG4105RI1 glycoprotein receptor E2R47_20880 ENOG4105C8Q Methyl-accepting chemotaxis E2R47_20885 ENOG4105D22 carbon starvation protein E2R47_20890 ENOG4105VCD cytoplasmic protein E2R47_20895 ENOG4105CKI cobalamin synthesis protein E2R47_20900 ENOG41063TF transcriptional regulator (AraC E2R47_20905 ENOG4105E82 cytochrome subunit of dehydrogenase E2R47_20910 ENOG4108HFV E2R47_20925 ENOG4105C26 Dehydrogenase E2R47_20930 ENOG4105DNE Transposase E2R47_20935 ENOG41083G8 Multidrug resistance protein MdtM E2R47_20940 ENOG4106BRA Membrane E2R47_20945 ENOG4105CBP Major Facilitator E2R47_20950 ENOG41074DU domain protein E2R47_20955 ENOG4108P2H Inner membrane protein YjiG E2R47_20960 ENOG4105DYB Isoaspartyl dipeptidase E2R47_20965 ENOG4107YNJ LysR family Transcriptional regulator E2R47_20985 ENOG4105C6F GntR Family Transcriptional Regulator E2R47_21010 ENOG4105KZM cytoplasmic protein E2R47_21025 ENOG4105DTA methyltransferase E2R47_21040 ENOG4107QVY Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E2R47_21200 ENOG4105DQ4 alcohol dehydrogenase E2R47_21205 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E2R47_21210 ENOG4105CPQ Dehydrogenase E2R47_21215 ENOG4105CHR reductase E2R47_21220 ENOG4105C6Z Gluconate E2R47_21225 ENOG4105K2J Transcriptional regulator E2R47_21230 ENOG4108K5H permease YjgP YjgQ family protein E2R47_21235 ENOG4108M8S permease YjgP YjgQ family protein E2R47_21250 ENOG4105MYG DNA polymerase iii, chi subunit E2R47_21255 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E2R47_21260 ENOG4108M3P Membrane E2R47_21265 ENOG4108MJ3 acetyltransferase E2R47_21275 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E2R47_21280 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) E2R47_21285 ENOG4105DBV ornithine carbamoyltransferase E2R47_21290 ENOG4105XEP YhcH YjgK YiaL family protein E2R47_21300 ENOG4105CEU Arginine dihydrolase E2R47_21305 ENOG4105C5B carbamate kinase E2R47_21310 ENOG4105DBV ornithine carbamoyltransferase E2R47_21315 ENOG4105CSX c4-dicarboxylate anaerobic carrier E2R47_21320 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) E2R47_21330 ENOG41077AM PyrBI operon attenuator E2R47_21345 ENOG4105KME endoribonuclease L-psp E2R47_21360 ENOG4105D4X repressor E2R47_21365 ENOG4105C5Y PTS System E2R47_21370 ENOG4105CG3 alpha amylase, catalytic region E2R47_21375 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E2R47_21380 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E2R47_21385 ENOG4105K4U addiction module toxin, RelE StbE family E2R47_21395 ENOG4105EMD TRANSCRIPTIONal E2R47_21410 ENOG41069H0 dihydroorotase EC 3.5.2.3 E2R47_21440 ENOG4108XVM Cytochrome b(562) E2R47_21445 ENOG4105CMS peptidase U62, modulator of DNA gyrase E2R47_21455 ENOG4105F0H myo-inositol catabolism protein E2R47_21465 ENOG4105IE8 Alpha-ketoglutarate permease E2R47_21470 ENOG4105CK5 oxidoreductase E2R47_21475 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) E2R47_21480 ENOG4105D7K pfkb domain protein E2R47_21490 ENOG4107VG4 Xylose isomerase domain protein TIM barrel E2R47_21495 ENOG4108MYR Secreted protein E2R47_21520 ENOG4105C26 Dehydrogenase E2R47_21525 ENOG4105DH8 myo-inositol catabolism E2R47_21530 ENOG4107QNK )-transporter E2R47_21540 ENOG4107QNK )-transporter E2R47_21545 ENOG4105CHC glucokinase (EC 2.7.1.2) E2R47_21555 ENOG4105DFU Cell wall formation (By similarity) E2R47_21565 ENOG4105F0N pyrophosphate phospho-hydrolase E2R47_21570 ENOG41069H0 dihydroorotase EC 3.5.2.3 E2R47_21575 ENOG4105DJB Major Facilitator Superfamily E2R47_21580 ENOG4108ZHD aig2 family E2R47_21600 ENOG4105C37 (CBS) domain E2R47_21605 ENOG41061GZ Protein of unknown function (DUF1107) E2R47_21610 ENOG4108UUE Transcriptional regulator E2R47_21615 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E2R47_21625 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E2R47_21630 ENOG4105KVH Transcriptional regulator E2R47_21635 ENOG4105ECR NmrA family E2R47_21640 ENOG4105DXC membrane E2R47_21655 ENOG4108V1T peptidylprolyl cis-trans isomerase E2R47_21660 ENOG4105FHY Opacity-associated protein A E2R47_21675 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E2R47_21685 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) E2R47_21690 ENOG4105KIT UPF0379 protein yjfY E2R47_21695 ENOG4105R3P Inner membrane protein yagU E2R47_21725 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E2R47_21740 ENOG4108MXZ Esterase E2R47_21745 ENOG4105WSB biofilm stress and motility protein A E2R47_21750 ENOG4105S17 UPF0379 protein yjfN E2R47_21755 ENOG4105CSU acyl-Coa dehydrogenase E2R47_21760 ENOG4106032 Glutathionylspermidine synthase E2R47_21765 ENOG4108KXT Conserved Protein E2R47_21770 ENOG4105Z6B inner membrane protein yjfl E2R47_21775 ENOG4107VNS Protein of unknown function (DUF2491) E2R47_21780 ENOG4108P9J Phage shock protein A E2R47_21785 ENOG4105FUX Conserved Protein E2R47_21790 ENOG4105C2N RNA methyltransferase TrmH family group 3 E2R47_21795 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E2R47_21820 ENOG4105EPW hflc protein E2R47_21825 ENOG4107QJR hflk protein E2R47_21830 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E2R47_21850 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E2R47_21855 ENOG4105K8N protein family UPF0079, ATPase E2R47_21860 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E2R47_21865 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E2R47_21885 ENOG4106TNF Periplasmic binding protein E2R47_21905 ENOG4105EGS Mechanosensitive ion channel E2R47_21910 ENOG4107SC7 Inner membrane transporter yjeM E2R47_21920 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E2R47_21925 ENOG4105E33 succinate dehydrogenase E2R47_21945 ENOG4105KPY Small multidrug resistance protein E2R47_21955 ENOG4106BSU Entericidin B E2R47_21975 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E2R47_21980 ENOG4105MTB Uncharacterized protein YjeJ E2R47_21985 ENOG4108ZVF (LipO)protein E2R47_22000 ENOG4105DVH amino acid E2R47_22005 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 E2R47_22010 ENOG4108IJ0 Aspartate ammonia-lyase E2R47_22015 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E2R47_22030 ENOG4108SIC Transcriptional regulator E2R47_22050 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E2R47_22055 ENOG4105UP7 3-epimerase E2R47_22060 ENOG4107WTH Galactitol-1-phosphate dehydrogenase E2R47_22065 ENOG41080HJ 6-phospho 3-hexuloisomerase E2R47_22070 ENOG4105CPQ Dehydrogenase E2R47_22075 ENOG4105F3R pts system mannose fructose sorbose family iid E2R47_22085 ENOG4108IQ3 PTS system E2R47_22090 ENOG4108EQA pts system E2R47_22100 ENOG4105SBG acid phosphatase E2R47_22135 ENOG41068CG regulatoR E2R47_22140 ENOG4105BZ1 (ABC) transporter E2R47_22150 ENOG4108ZK4 sdia-regulated domain-containing protein E2R47_22160 ENOG4108NEM leader-binding protein dmsD E2R47_22165 ENOG4107KGK dmso reductase anchor subunit E2R47_22170 ENOG4105QAX Iron-sulfur E2R47_22175 ENOG4107QY8 reductase E2R47_22180 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E2R47_22185 ENOG4108MRH transcriptional regulatory protein E2R47_22195 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E2R47_22200 ENOG4107GFK fumarate E2R47_22205 ENOG4105CT4 transporter E2R47_22210 ENOG4105F8D glycoside hydrolase family 4 E2R47_22215 ENOG4108K2B transcriptional regulator E2R47_22220 ENOG4105CXN decarboxylase E2R47_22225 ENOG4106ZGR Transcriptional regulator E2R47_22230 ENOG4105D5Q Arginine ornithine antiporter E2R47_22235 ENOG4105DIJ Phosphoethanolamine transferase E2R47_22240 ENOG4105XJC Two component transcriptional regulator (Winged helix family E2R47_22245 ENOG4105ECM Sensor protein basS pmrB E2R47_22255 ENOG4105CSH Transporter E2R47_22260 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E2R47_22265 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase E2R47_22270 ENOG410870W N-acetyltransferase E2R47_22285 ENOG41082ND Uncharacterized protein yjcO E2R47_22295 ENOG4105CK2 sodium dicarboxylate symporter E2R47_22300 ENOG4108W0S formate-dependent nitrite reductase complex E2R47_22310 ENOG4108QKW cytochrome c-type biogenesis protein E2R47_22315 ENOG4105DVI reductase, NrfD E2R47_22320 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E2R47_22325 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit E2R47_22330 ENOG4105EAU Plays a role in nitrite reduction (By similarity) E2R47_22335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E2R47_22340 ENOG41062QD Membrane E2R47_22350 ENOG41067MG lrgb family E2R47_22360 ENOG4105CMU LysR family (Transcriptional regulator E2R47_22365 ENOG4105EEQ Na H antiporter E2R47_22375 ENOG4105C7N Xanthine uracil vitamin C permease E2R47_22385 ENOG4108Z4X TRANSCRIPTIONal E2R47_22390 ENOG4108W3Q Transcriptional regulator E2R47_22395 ENOG4108M8H domain protein E2R47_22400 ENOG4105PMV Membrane E2R47_22435 ENOG4108UUM single-stranded DNA-binding protein E2R47_22445 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E2R47_22460 ENOG4105MSB protein, conserved in bacteria E2R47_22465 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme E2R47_22470 ENOG4105F0S class B acid phosphatase E2R47_22475 ENOG4105CGF Aromatic amino acid aminotransferase E2R47_22480 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E2R47_22485 ENOG4105CDU Replicative dna helicase E2R47_22490 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E2R47_22495 ENOG4105P4Z Phage shock protein G E2R47_22500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E2R47_22510 ENOG4105MYN Zinc uptake regulation protein E2R47_22515 ENOG4105VDW Csbd family E2R47_22525 ENOG4107R73 Mate efflux family protein E2R47_22535 ENOG41080IJ Diacylglycerol kinase E2R47_22555 ENOG4107W52 maltose operon periplasmic protein E2R47_22570 ENOG4107FKK extracellular solute-binding protein family 1 E2R47_22575 ENOG4105D56 permease protein E2R47_22580 ENOG4105EG2 ABC transporter, permease E2R47_22590 ENOG4105E3R (LipO)protein E2R47_22595 ENOG4108Q9C Periplasmic Protein E2R47_22600 ENOG4108MDC (LipO)protein E2R47_22615 ENOG4105CFH Aspartokinase E2R47_22700 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E2R47_22705 ENOG4105CKK Glycosyl transferase, family 2 E2R47_22730 ENOG4108X9F tail fiber protein E2R47_22755 ENOG4105C09 Bile acid E2R47_22760 ENOG4108ZR5 Conserved Protein E2R47_22765 ENOG4105FE9 pseudouridine synthase E2R47_22770 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E2R47_22785 ENOG4105EAM Na Pi-cotransporter E2R47_22790 ENOG4105C3R Methionine synthase E2R47_22795 ENOG41069M3 Transcriptional regulator E2R47_22810 ENOG4108I9X Isocitrate lyase E2R47_22815 ENOG4107QP3 malate synthase g E2R47_22825 ENOG4105K5X acetyltransferase E2R47_22855 ENOG4105C12 Phosphoribosylglycinamide synthetase E2R47_22860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E2R47_22865 ENOG4105BZU Histidine kinase E2R47_22875 ENOG4108T8B Protein of unknown function (DUF1481) E2R47_22880 ENOG4105K70 DNA-binding protein E2R47_22885 ENOG4105R2J Conserved Protein E2R47_22920 ENOG4105D06 uba thif-type nad fad binding protein E2R47_22925 ENOG4105WHD thiamine biosynthesis protein ThiS E2R47_22935 ENOG4105D41 biosynthesis protein thiH E2R47_22970 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) E2R47_22990 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E2R47_22995 ENOG4105PM1 preprotein translocase subunit SecE E2R47_23000 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E2R47_23035 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase E2R47_23090 ENOG4108Y73 Membrane E2R47_23105 ENOG4105C5Q Transcriptional regulator E2R47_23140 ENOG4105DIJ Phosphoethanolamine transferase E2R47_23145 ENOG4106R3P AraC family transcriptional regulator E2R47_23155 ENOG4105DCT glycerol dehydrogenase E2R47_23160 ENOG4108XC3 NADH ubiquinone oxidoreductase E2R47_23170 ENOG4105SYT Methylenetetrahydrofolate reductase E2R47_23175 ENOG4105CGH 5'-nucleotidase E2R47_23190 ENOG4105D64 Mechanosensitive ion channel E2R47_23195 ENOG4105CFH Aspartokinase E2R47_23200 ENOG4105C28 cystathionine E2R47_23210 ENOG4108MR7 Arylsulfotransferase E2R47_23225 ENOG4105C25 Primosomal protein n' E2R47_23230 ENOG4105ETE Transcriptional regulator (LacI family E2R47_23235 ENOG41063M6 Cell Division Protein E2R47_23250 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E2R47_23260 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) E2R47_23265 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E2R47_23275 ENOG4105CBT Fructose-1,6-bisphosphatase E2R47_23280 ENOG4105DP0 ferredoxin-NADP reductase E2R47_23285 ENOG4108VTS Membrane E2R47_23290 ENOG4105EBK exported protein E2R47_23315 ENOG4105D4B ABC, transporter E2R47_23330 ENOG4105C2J ABC transporter E2R47_23340 ENOG4107RYS Autoinducer-2 (AI-2) kinase E2R47_23350 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) E2R47_23370 ENOG4105D7K pfkb domain protein E2R47_23375 ENOG4105CT4 transporter E2R47_23385 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E2R47_23400 ENOG4105FMW periplasmic E2R47_23405 ENOG4105E3W Two component transcriptional regulator (Winged helix family E2R47_23410 ENOG4105E0F Histidine kinase E2R47_23420 ENOG4108RPX mosc domain containing protein E2R47_23425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E2R47_23430 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E2R47_23435 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E2R47_23440 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E2R47_23445 ENOG4108QGT oligogalacturonate-specific porin E2R47_23470 ENOG4105DKG l-rhamnose isomerase E2R47_23480 ENOG4105C0A alcohol dehydrogenase E2R47_23495 ENOG4108UMN azlc family E2R47_23505 ENOG4108V87 frv operon regulatory protein E2R47_23510 ENOG4108V87 frv operon regulatory protein E2R47_23520 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E2R47_23525 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E2R47_23530 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E2R47_23535 ENOG4108MG3 formate dehydrogenase E2R47_23550 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system E2R47_23560 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) E2R47_23565 ENOG4108Z3N Transcriptional regulator E2R47_23570 ENOG4105SUU thioesterase domain E2R47_23585 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 E2R47_23590 ENOG4105E98 transcriptional regulator DeoR family E2R47_23595 ENOG4108MGF sugar kinase E2R47_23600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E2R47_23605 ENOG4105D2M Aldolase E2R47_23610 ENOG4107QKS N-acylglucosamine 2-epimerase E2R47_23615 ENOG4107WI4 Aldose-1-epimerase E2R47_23620 ENOG4105CJQ hydrolase, family 31 E2R47_23625 ENOG4105CT4 transporter E2R47_23630 ENOG4105CT4 transporter E2R47_23635 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is E2R47_23665 ENOG4108K4B hydrolase E2R47_23675 ENOG4105C5F glutamine synthetase E2R47_23685 ENOG4105CUX Signal transduction histidine kinase E2R47_23690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E2R47_23695 ENOG4106FIY E2R47_23700 ENOG4105D4P Coproporphyrinogen iii oxidase E2R47_23725 ENOG4105C2M dna polymerase I E2R47_23735 ENOG4106HNH Acyl-transferase E2R47_23750 ENOG4105PC1 Conserved Protein E2R47_23755 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E2R47_23760 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b E2R47_23790 ENOG4108RR8 protoporphyrinogen oxidase E2R47_23795 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) E2R47_23800 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E2R47_23820 ENOG4108MR7 Arylsulfotransferase E2R47_23825 ENOG4107QK7 reductase E2R47_23830 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E2R47_23835 ENOG4105MDZ Transcriptional activator rfaH E2R47_23840 ENOG4105F8V Hydrolase, tatD family E2R47_23845 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E2R47_23855 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E2R47_23865 ENOG4105JC1 sterol-binding domain protein E2R47_23875 ENOG4105CGY Dna recombination protein E2R47_23880 ENOG4108I5U Uridine phosphorylase E2R47_23885 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) E2R47_23890 ENOG4105C4X radical SAM domain protein E2R47_23905 ENOG4105DZ2 Transcriptional regulator E2R47_23910 ENOG4105EMK carboxylate amino acid amine transporter E2R47_23915 ENOG4105DQF Hydrolase E2R47_23920 ENOG4108EUD Lysophospholipase E2R47_23925 ENOG410829K Lysine exporter protein (Lyse ygga) E2R47_23930 ENOG4105CCF Lysine exporter protein (Lyse ygga) E2R47_23935 ENOG4105C9U ATP-dependent DNA helicase RecQ E2R47_23940 ENOG4105HDD phospholipase E2R47_23945 ENOG4108VUY thioesterase Superfamily protein E2R47_23950 ENOG4105FR1 rard protein E2R47_23955 ENOG4106WR8 Inner membrane protein YigG E2R47_23960 ENOG4105NRM Membrane E2R47_23975 ENOG4105C4R Atp-dependent dna helicase E2R47_23980 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant E2R47_23985 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E2R47_23990 ENOG4105CT0 Protein of unknown function, DUF484 E2R47_24000 ENOG4105S7Z (LipO)protein E2R47_24035 ENOG4107T0K Adenylate cyclase E2R47_24045 ENOG41076E6 Uroporphyrinogen-III Synthase E2R47_24050 ENOG4105ECF c-methyltransferase E2R47_24055 ENOG410601J HemY protein E2R47_24080 ENOG4105C85 amino acid E2R47_24095 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) E2R47_24100 ENOG4105EGZ biosynthesis protein E2R47_24105 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E2R47_24110 ENOG4108WJ1 acetyltransferase E2R47_24115 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E2R47_24115 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E2R47_24120 ENOG4105C1B dTDP-glucose 4-6-dehydratase E2R47_24125 ENOG4108IJ1 Dehydrogenase E2R47_24130 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E2R47_24135 ENOG4105SFE lipopolysaccharide biosynthesis protein E2R47_24140 ENOG4105ESV Glycosyl transferase, family 4 E2R47_24145 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E2R47_24155 ENOG4105K63 Thioredoxin E2R47_24170 ENOG4105C4R Atp-dependent dna helicase E2R47_24175 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E2R47_24180 ENOG4107SXA Phosphorylase E2R47_24190 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E2R47_24200 ENOG4105EMY transcriptional regulator E2R47_24215 ENOG4105C7B Threonine dehydratase E2R47_24225 ENOG4105CM2 brancheD-chain amino acid aminotransferase E2R47_24230 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit E2R47_24250 ENOG4105C0P Mg chelatase subunit ChlI E2R47_24295 ENOG4107EJG GntR family transcriptional regulator E2R47_24300 ENOG4105C0R drug resistance transporter emrb qaca subfamily E2R47_24305 ENOG4105ETE Transcriptional regulator (LacI family E2R47_24310 ENOG4108RVA ribokinase E2R47_24315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E2R47_24320 ENOG4105CNN ABC, transporter E2R47_24325 ENOG4105C2J ABC transporter E2R47_24355 ENOG4108VVK transcriptional Regulator, AsnC E2R47_24360 ENOG4105QTB Flavodoxin E2R47_24380 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation E2R47_24390 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E2R47_24420 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) E2R47_24445 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E2R47_24450 ENOG4105F9E Shikimate 5-dehydrogenase E2R47_24455 ENOG4105DM4 PTS System E2R47_24460 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) E2R47_24465 ENOG4105C8U phosphate abc transporter E2R47_24470 ENOG4105E2Z phosphate ABC transporter (Permease E2R47_24485 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 E2R47_24490 ENOG4105C7N Xanthine uracil vitamin C permease E2R47_24495 ENOG4108YYH Nadph-dependent fmn reductase E2R47_24500 ENOG4105E8Q phosphopantetheinyl transferase E2R47_24505 ENOG4105G2Y Transcriptional regulator