locus-tag	class	description
HIX64_00015	COG2856	Zn peptidase
HIX64_00030	COG4695	Portal protein
HIX64_00130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HIX64_00140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HIX64_00205	COG2211	Major facilitator Superfamily
HIX64_00210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIX64_00240	COG1070	Carbohydrate kinase
HIX64_00295	COG3152	Membrane
HIX64_00305	COG1494	fructose-1,6-bisphosphatase
HIX64_00315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HIX64_00330	COG1575	Belongs to the MenA family. Type 1 subfamily
HIX64_00345	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HIX64_00350	COG1609	Transcriptional regulator
HIX64_00355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIX64_00380	COG0626	cystathionine gamma-synthase activity
HIX64_00385	COG0460	homoserine dehydrogenase
HIX64_00385	COG0527	aspartate kinase activity
HIX64_00390	COG0668	transmembrane transport
HIX64_00405	COG0737	Belongs to the 5'-nucleotidase family
HIX64_00420	COG3738	Protein conserved in bacteria
HIX64_00425	COG0371	Dehydrogenase
HIX64_00435	COG2207	Transcriptional regulator
HIX64_00475	COG0583	DNA-binding transcription factor activity
HIX64_00585	COG0250	Participates in transcription elongation, termination and antitermination
HIX64_00645	COG2104	thiamine diphosphate biosynthetic process
HIX64_00650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HIX64_00715	COG0151	Belongs to the GarS family
HIX64_00755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HIX64_00800	COG3122	Protein conserved in bacteria
HIX64_00840	COG5301	cellulose 1,4-beta-cellobiosidase activity
HIX64_00870	COG2246	polysaccharide biosynthetic process
HIX64_00950	COG0527	aspartate kinase activity
HIX64_00975	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIX64_01030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HIX64_01040	COG0534	Mate efflux family protein
HIX64_01055	COG0735	belongs to the Fur family
HIX64_01110	COG2315	Protein conserved in bacteria
HIX64_01170	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HIX64_01190	COG2252	PERMEase
HIX64_01195	COG0025	NhaP-type Na H and K H
HIX64_01200	COG0583	DNA-binding transcription factor activity
HIX64_01205	COG1380	Effector of murein hydrolase LrgA
HIX64_01210	COG1346	cytolysis
HIX64_01220	COG3162	membrane
HIX64_01225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIX64_01235	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HIX64_01240	COG0437	4 iron, 4 sulfur cluster binding
HIX64_01245	COG3301	Polysulphide reductase, NrfD
HIX64_01250	COG1138	Cytochrome C-type biogenesis protein
HIX64_01255	COG3088	subunit of a heme lyase
HIX64_01260	COG4235	cytochrome complex assembly
HIX64_01265	COG1301	dicarboxylic acid transport
HIX64_01270	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HIX64_01290	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HIX64_01295	COG2824	Alkylphosphonate utilization operon protein PhnA
HIX64_01325	COG0531	amino acid
HIX64_01330	COG2207	Transcriptional regulator
HIX64_01335	COG1982	Orn Lys Arg decarboxylase major
HIX64_01340	COG2169	Transcriptional regulator
HIX64_01355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HIX64_01355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIX64_01360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HIX64_01370	COG4565	transcriptional regulatory protein
HIX64_01375	COG3290	protein histidine kinase activity
HIX64_01380	COG0243	molybdopterin cofactor binding
HIX64_01385	COG0437	4 iron, 4 sulfur cluster binding
HIX64_01390	COG3302	dmso reductase anchor subunit
HIX64_01395	COG3381	protein complex oligomerization
HIX64_01420	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HIX64_01425	COG2197	response regulator
HIX64_01470	COG1309	transcriptional regulator
HIX64_01485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HIX64_01490	COG1027	Aspartate ammonia-lyase
HIX64_01495	COG3030	protein affecting phage T7 exclusion by the F plasmid
HIX64_01500	COG0531	amino acid
HIX64_01540	COG5510	response to toxic substance
HIX64_01570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HIX64_01575	COG1053	succinate dehydrogenase
HIX64_01595	COG3264	Mechanosensitive ion channel
HIX64_01595	COG1511	domain protein
HIX64_01615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIX64_01640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HIX64_01640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HIX64_01645	COG0802	atpase or kinase
HIX64_01670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HIX64_01675	COG0330	HflC and HflK could
HIX64_01680	COG0330	HflC and HflK could
HIX64_01685	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HIX64_01700	COG0557	exoribonuclease II activity
HIX64_01710	COG3789	protein conserved in bacteria
HIX64_01715	COG1842	Phage shock protein A
HIX64_01730	COG3766	membrane
HIX64_01735	COG5463	Belongs to the UPF0441 family
HIX64_01740	COG0754	glutathionylspermidine amidase activity
HIX64_01745	COG1960	acyl-CoA dehydrogenase activity
HIX64_01755	COG3650	response to hydrogen peroxide
HIX64_01760	COG1073	alpha beta
HIX64_01775	COG3037	sugar-specific permease SgaT UlaA
HIX64_01780	COG3414	Phosphotransferase system galactitol-specific IIB component
HIX64_01825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HIX64_01840	COG3061	Opacity-associated protein A
HIX64_01845	COG0545	Peptidyl-prolyl cis-trans isomerase
HIX64_01850	COG1113	amino acid transport
HIX64_01860	COG0697	spore germination
HIX64_01865	COG0702	epimerase
HIX64_01870	COG1733	regulation of RNA biosynthetic process
HIX64_01895	COG1253	flavin adenine dinucleotide binding
HIX64_01915	COG2105	PFAM AIG2 family protein
HIX64_01920	COG2271	Major facilitator Superfamily
HIX64_01925	COG3964	amidohydrolase
HIX64_01940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HIX64_01945	COG0837	glucose binding
HIX64_01945	COG1737	Transcriptional regulator
HIX64_01950	COG2814	Major facilitator Superfamily
HIX64_01950	COG0477	Major facilitator Superfamily
HIX64_01960	COG2814	Major facilitator Superfamily
HIX64_01960	COG0477	Major facilitator Superfamily
HIX64_01970	COG3718	enzyme involved in inositol metabolism
HIX64_02000	COG5520	Belongs to the glycosyl hydrolase 30 family
HIX64_02005	COG1082	Xylose isomerase domain protein TIM barrel
HIX64_02015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_02020	COG3962	Belongs to the TPP enzyme family
HIX64_02025	COG0673	inositol 2-dehydrogenase activity
HIX64_02030	COG2814	Major facilitator Superfamily
HIX64_02040	COG1082	Xylose isomerase domain protein TIM barrel
HIX64_02050	COG0312	modulator of DNA gyrase
HIX64_02085	COG3964	amidohydrolase
HIX64_02100	COG3711	transcriptional antiterminator
HIX64_02100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_02105	COG3077	Addiction module antitoxin, RelB DinJ family
HIX64_02110	COG2026	Addiction module toxin, RelE StbE family
HIX64_02125	COG0366	Alpha amylase catalytic
HIX64_02130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HIX64_02130	COG1263	PTS System
HIX64_02180	COG1438	arginine binding
HIX64_02185	COG1288	antiporter activity
HIX64_02205	COG2731	YhcH YjgK YiaL family protein
HIX64_02245	COG2927	DNA polymerase III (CHI subunit)
HIX64_02255	COG0795	lipopolysaccharide-transporting ATPase activity
HIX64_02260	COG0795	lipopolysaccharide-transporting ATPase activity
HIX64_02265	COG1609	Transcriptional regulator
HIX64_02270	COG2610	gluconate transmembrane transporter activity
HIX64_02275	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_02280	COG1063	alcohol dehydrogenase
HIX64_02285	COG3265	gluconokinase activity
HIX64_02290	COG1064	alcohol dehydrogenase
HIX64_02325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HIX64_02350	COG0412	Dienelactone hydrolase
HIX64_02355	COG2186	Transcriptional regulator
HIX64_02375	COG0583	DNA-binding transcription factor activity
HIX64_02380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HIX64_02385	COG0700	Nucleoside recognition
HIX64_02390	COG3366	ferrous iron transmembrane transporter activity
HIX64_02395	COG0477	Major facilitator Superfamily
HIX64_02400	COG2733	membrane
HIX64_02410	COG5464	transposase or invertase
HIX64_02415	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_02440	COG1280	lysine exporter protein (LysE YggA)
HIX64_02450	COG0523	cobalamin synthesis protein
HIX64_02455	COG2879	small protein
HIX64_02460	COG1966	Carbon starvation protein
HIX64_02465	COG0840	transmembrane signaling receptor activity
HIX64_02480	COG1484	DNA-dependent DNA replication
HIX64_02495	COG2966	Psort location CytoplasmicMembrane, score
HIX64_02500	COG2197	response regulator
HIX64_02505	COG2197	response regulator
HIX64_02510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIX64_02515	COG4114	ferric iron reductase
HIX64_02520	COG3706	GGDEF domain
HIX64_02550	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HIX64_02560	COG1011	Hydrolase
HIX64_02570	COG2823	Periplasmic or secreted lipoprotein
HIX64_02580	COG4667	esterase of the alpha-beta hydrolase superfamily
HIX64_02585	COG0084	hydrolase, TatD family'
HIX64_02590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HIX64_02595	COG1328	CTP reductase activity
HIX64_02620	COG3550	peptidyl-serine autophosphorylation
HIX64_02630	COG3726	membrane protein affecting hemolysin expression
HIX64_02635	COG0560	Phosphoserine phosphatase
HIX64_02650	COG0488	(ABC) transporter
HIX64_02675	COG3708	Transcriptional regulator
HIX64_02675	COG2207	Transcriptional regulator
HIX64_02680	COG3045	CreA protein
HIX64_02685	COG0745	RESPONSE REGULATOR receiver
HIX64_02690	COG2205	protein histidine kinase activity
HIX64_02695	COG4452	Inner membrane protein CreD
HIX64_02715	COG3121	Chaperone
HIX64_02735	COG0745	RESPONSE REGULATOR receiver
HIX64_02745	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HIX64_02755	COG0460	homoserine dehydrogenase
HIX64_02755	COG0527	aspartate kinase activity
HIX64_02765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HIX64_02775	COG1115	amino acid carrier protein
HIX64_02785	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIX64_02790	COG1584	GPR1 FUN34 yaaH family protein
HIX64_02795	COG4735	regulation of single-species biofilm formation
HIX64_02855	COG3121	Chaperone
HIX64_02860	COG3188	usher protein
HIX64_02875	COG3539	Fimbrial protein
HIX64_02880	COG3121	Chaperone
HIX64_02915	COG3119	arylsulfatase activity
HIX64_02920	COG0641	radical SAM
HIX64_02945	COG0583	DNA-binding transcription factor activity
HIX64_02970	COG0196	riboflavin kinase activity
HIX64_02985	COG1047	Peptidyl-prolyl cis-trans
HIX64_03015	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HIX64_03130	COG0644	oxidoreductase
HIX64_03140	COG2271	Major facilitator Superfamily
HIX64_03160	COG3119	arylsulfatase activity
HIX64_03195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HIX64_03225	COG0417	DNA replication proofreading
HIX64_03265	COG0586	Pfam SNARE associated Golgi protein
HIX64_03270	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HIX64_03360	COG0768	penicillin binding
HIX64_03365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIX64_03370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HIX64_03385	COG0772	Belongs to the SEDS family
HIX64_03410	COG0849	cell division
HIX64_03415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HIX64_03435	COG0494	nUDIX hydrolase
HIX64_03440	COG0667	Aldo Keto reductase
HIX64_03470	COG1459	type II secretion system
HIX64_03475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HIX64_03480	COG4969	Belongs to the N-Me-Phe pilin family
HIX64_03495	COG3725	Membrane protein required for beta-lactamase induction
HIX64_03500	COG3940	Belongs to the glycosyl hydrolase 43 family
HIX64_03505	COG2211	Major facilitator Superfamily
HIX64_03520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HIX64_03525	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIX64_03530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIX64_03545	COG3064	Membrane
HIX64_03585	COG1349	DNA-binding transcription factor activity
HIX64_03605	COG2132	Multicopper oxidase
HIX64_03610	COG4993	Dehydrogenase
HIX64_03620	COG0288	reversible hydration of carbon dioxide
HIX64_03625	COG1131	(ABC) transporter
HIX64_03630	COG0842	Transport permease protein
HIX64_03635	COG3539	Fimbrial protein
HIX64_03655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_03660	COG0726	polysaccharide deacetylase
HIX64_03680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HIX64_03685	COG0617	tRNA 3'-terminal CCA addition
HIX64_03705	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HIX64_03710	COG1643	Atp-dependent helicase
HIX64_03715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HIX64_03720	COG4774	siderophore transport
HIX64_03725	COG1120	ATPase activity
HIX64_03730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HIX64_03745	COG3188	usher protein
HIX64_03750	COG3121	Chaperone
HIX64_03755	COG3539	Fimbrial protein
HIX64_03760	COG3539	Fimbrial protein
HIX64_03790	COG2860	membrane
HIX64_03815	COG3835	regulator
HIX64_03825	COG0477	Major facilitator Superfamily
HIX64_03875	COG0575	Belongs to the CDS family
HIX64_03935	COG1982	Orn Lys Arg decarboxylase major
HIX64_03940	COG0346	lactoylglutathione lyase activity
HIX64_03950	COG4568	rho-dependent transcription termination
HIX64_03965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HIX64_03970	COG3015	lipoprotein NlpE involved in copper resistance
HIX64_03980	COG1720	tRNA m6t6A37 methyltransferase activity
HIX64_04005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HIX64_04040	COG0656	L-ascorbic acid biosynthetic process
HIX64_04045	COG0583	DNA-binding transcription factor activity
HIX64_04050	COG2814	Major facilitator Superfamily
HIX64_04060	COG2226	methyltransferase
HIX64_04065	COG1388	LysM domain
HIX64_04065	COG0741	lytic transglycosylase activity
HIX64_04075	COG2226	methyltransferase
HIX64_04180	COG3047	cAMP biosynthetic process
HIX64_04180	COG2885	chlorophyll binding
HIX64_04235	COG3209	COG3209 Rhs family protein
HIX64_04375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIX64_04390	COG0121	glutamine amidotransferase
HIX64_04395	COG3034	peptidoglycan biosynthetic process
HIX64_04405	COG1690	Belongs to the RtcB family
HIX64_04410	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HIX64_04415	COG2195	Cleaves the N-terminal amino acid of tripeptides
HIX64_04455	COG0582	viral genome integration into host DNA
HIX64_04475	COG2814	Major facilitator Superfamily
HIX64_04490	COG0179	Fumarylacetoacetate (FAA) hydrolase
HIX64_04525	COG3188	usher protein
HIX64_04530	COG3121	Chaperone
HIX64_04535	COG3539	Fimbrial protein
HIX64_04550	COG2200	EAL domain
HIX64_04600	COG2217	Heavy metal translocating P-type atpase
HIX64_04605	COG0789	Transcriptional regulator
HIX64_04615	COG2814	Major facilitator Superfamily
HIX64_04635	COG1271	oxidase subunit
HIX64_04640	COG1294	oxidase, subunit
HIX64_04660	COG1280	lysine exporter protein (LysE YggA)
HIX64_04695	COG0113	porphobilinogen synthase activity
HIX64_04710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HIX64_04715	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HIX64_04760	COG3706	GGDEF domain
HIX64_04765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HIX64_04785	COG4126	flavin adenine dinucleotide binding
HIX64_04800	COG1940	carbohydrate kinase activity
HIX64_04805	COG2814	Major facilitator Superfamily
HIX64_04810	COG0419	ATPase involved in DNA repair
HIX64_04815	COG0420	3'-5' exonuclease activity
HIX64_04825	COG5002	protein histidine kinase activity
HIX64_04840	COG0366	Alpha amylase catalytic
HIX64_04845	COG0450	alkyl hydroperoxide reductase
HIX64_04865	COG1862	Preprotein translocase
HIX64_04875	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIX64_04910	COG4238	major outer membrane lipoprotein
HIX64_04935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HIX64_04940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HIX64_04945	COG0667	Aldo Keto reductase
HIX64_04955	COG0142	geranyltranstransferase activity
HIX64_04990	COG2188	Transcriptional regulator
HIX64_05020	COG2814	Major facilitator Superfamily
HIX64_05040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HIX64_05045	COG1845	cytochrome c oxidase, subunit III
HIX64_05050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HIX64_05055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HIX64_05060	COG2223	nitrite transmembrane transporter activity
HIX64_05065	COG3056	Lipoprotein
HIX64_05070	COG0271	Belongs to the BolA IbaG family
HIX64_05090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HIX64_05100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIX64_05105	COG1555	photosystem II stabilization
HIX64_05110	COG0824	Thioesterase
HIX64_05120	COG4533	DNA binding
HIX64_05135	COG1522	sequence-specific DNA binding
HIX64_05140	COG1132	(ABC) transporter
HIX64_05145	COG1132	(ABC) transporter
HIX64_05150	COG0347	Belongs to the P(II) protein family
HIX64_05155	COG0004	ammonium transporteR
HIX64_05160	COG1946	Acyl-CoA thioesterase
HIX64_05165	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HIX64_05170	COG3695	enzyme binding
HIX64_05180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HIX64_05200	COG0110	maltose O-acetyltransferase activity
HIX64_05215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIX64_05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIX64_05225	COG1309	transcriptional regulator
HIX64_05230	COG3264	Mechanosensitive ion channel
HIX64_05230	COG1196	nuclear chromosome segregation
HIX64_05250	COG3923	Primosomal replication protein n
HIX64_05255	COG2832	Protein of unknown function (DUF454)
HIX64_05300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_05305	COG4651	solute:proton antiporter activity
HIX64_05305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIX64_05310	COG2223	nitrite transmembrane transporter activity
HIX64_05325	COG3735	TraB family
HIX64_05335	COG2217	Heavy metal translocating P-type atpase
HIX64_05345	COG1585	Membrane protein implicated in regulation of membrane protease activity
HIX64_05350	COG0330	HflC and HflK could
HIX64_05355	COG4619	ABC transporter
HIX64_05360	COG0390	transport system, permease component
HIX64_05365	COG3118	belongs to the thioredoxin family
HIX64_05370	COG0300	oxidoreductase activity
HIX64_05375	COG2755	lipolytic protein G-D-S-L family
HIX64_05380	COG4181	ATPase activity
HIX64_05385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HIX64_05395	COG1464	Belongs to the NlpA lipoprotein family
HIX64_05430	COG3960	tartronate-semialdehyde synthase activity
HIX64_05435	COG3622	Belongs to the hyi family
HIX64_05440	COG2084	Dehydrogenase
HIX64_05450	COG1953	Uracil, thiamine, allantoin
HIX64_05460	COG2233	PERMEase
HIX64_05465	COG1929	Belongs to the glycerate kinase type-1 family
HIX64_05470	COG3257	ureidoglycine aminohydrolase activity
HIX64_05475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HIX64_05480	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HIX64_05485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HIX64_05490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HIX64_05500	COG0549	Belongs to the carbamate kinase family
HIX64_05505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIX64_05510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HIX64_05520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HIX64_05540	COG1988	membrane-bound metal-dependent
HIX64_05545	COG2501	S4 domain
HIX64_05625	COG2246	polysaccharide biosynthetic process
HIX64_05630	COG0463	Glycosyl transferase, family 2
HIX64_05650	COG0463	Glycosyl transferase, family 2
HIX64_05655	COG2246	polysaccharide biosynthetic process
HIX64_05675	COG2207	Transcriptional regulator
HIX64_05680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIX64_05690	COG3059	membrane
HIX64_05700	COG1113	amino acid transport
HIX64_05705	COG0668	transmembrane transport
HIX64_05720	COG2315	Protein conserved in bacteria
HIX64_05740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HIX64_05745	COG2977	Belongs to the P-Pant transferase superfamily
HIX64_05750	COG4771	TonB-dependent receptor
HIX64_05755	COG2382	esterase
HIX64_05760	COG3251	PFAM MbtH domain protein
HIX64_05770	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HIX64_05775	COG1120	ATPase activity
HIX64_05780	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIX64_05785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIX64_05795	COG4592	Periplasmic binding protein
HIX64_05800	COG1169	isochorismate synthase
HIX64_05805	COG1021	2,3-dihydroxybenzoate-AMP ligase
HIX64_05810	COG3433	isochorismatase activity
HIX64_05810	COG1535	isochorismatase
HIX64_05815	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_05825	COG1966	Carbon starvation protein
HIX64_05830	COG2879	small protein
HIX64_05835	COG0371	Dehydrogenase
HIX64_05840	COG0436	Aminotransferase
HIX64_05845	COG1475	DNA binding
HIX64_05850	COG3969	phosphoadenosine phosphosulfate
HIX64_05855	COG0583	DNA-binding transcription factor activity
HIX64_05860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIX64_05880	COG0243	molybdopterin cofactor binding
HIX64_05900	COG1063	alcohol dehydrogenase
HIX64_05905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIX64_05910	COG3719	Belongs to the RNase T2 family
HIX64_05915	COG0471	metal ion transport
HIX64_05930	COG3051	citrate lyase alpha subunit
HIX64_05935	COG2301	Belongs to the HpcH HpaI aldolase family
HIX64_05945	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HIX64_05950	COG3290	protein histidine kinase activity
HIX64_05955	COG4565	transcriptional regulatory protein
HIX64_05960	COG3069	C4-dicarboxylate transmembrane transporter activity
HIX64_05980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIX64_05995	COG0583	DNA-binding transcription factor activity
HIX64_06010	COG1686	Belongs to the peptidase S11 family
HIX64_06020	COG0772	Belongs to the SEDS family
HIX64_06025	COG0768	penicillin binding
HIX64_06035	COG0799	negative regulation of ribosome biogenesis
HIX64_06045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HIX64_06055	COG1466	dna polymerase III delta subunit
HIX64_06085	COG3829	transcription factor binding
HIX64_06085	COG3290	protein histidine kinase activity
HIX64_06090	COG2888	peptidyl-tyrosine sulfation
HIX64_06105	COG2214	Heat shock protein DnaJ domain protein
HIX64_06115	COG2214	Heat shock protein DnaJ domain protein
HIX64_06120	COG0443	Heat shock 70 kDa protein
HIX64_06135	COG1126	abc transporter atp-binding protein
HIX64_06140	COG0765	amino acid transport
HIX64_06145	COG0765	amino acid transport
HIX64_06170	COG1702	phosphate starvation-inducible protein PhoH
HIX64_06180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIX64_06225	COG0367	asparagine synthase
HIX64_06230	COG0647	UMP catabolic process
HIX64_06235	COG1940	carbohydrate kinase activity
HIX64_06235	COG1846	Transcriptional regulator
HIX64_06240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HIX64_06280	COG1053	succinate dehydrogenase
HIX64_06285	COG0583	DNA-binding transcription factor activity
HIX64_06290	COG0735	belongs to the Fur family
HIX64_06310	COG0596	Alpha beta hydrolase
HIX64_06320	COG0033	Phosphoglucomutase
HIX64_06330	COG0531	amino acid
HIX64_06335	COG1982	Orn Lys Arg decarboxylase major
HIX64_06345	COG0745	RESPONSE REGULATOR receiver
HIX64_06350	COG2205	protein histidine kinase activity
HIX64_06365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HIX64_06395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HIX64_06400	COG1984	allophanate hydrolase subunit 2
HIX64_06415	COG3180	Ammonia monooxygenase
HIX64_06435	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HIX64_06450	COG0567	Dehydrogenase, E1 component
HIX64_06455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIX64_06465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HIX64_06470	COG1271	oxidase subunit
HIX64_06475	COG1294	oxidase, subunit
HIX64_06480	COG4890	Cyd operon protein YbgT
HIX64_06485	COG3790	cyd operon protein YbgE
HIX64_06490	COG0824	Thioesterase
HIX64_06495	COG0811	peptide transport
HIX64_06500	COG0848	biopolymer transport protein
HIX64_06505	COG3064	Membrane
HIX64_06515	COG2885	chlorophyll binding
HIX64_06520	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HIX64_06560	COG1230	cation diffusion facilitator family transporter
HIX64_06570	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HIX64_06575	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIX64_06575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HIX64_06585	COG0583	DNA-binding transcription factor activity
HIX64_06590	COG0583	DNA-binding transcription factor activity
HIX64_06595	COG0471	metal ion transport
HIX64_06595	COG0490	domain, Protein
HIX64_06605	COG0511	ligase activity, forming carbon-carbon bonds
HIX64_06605	COG5016	pyruvate
HIX64_06610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HIX64_06625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIX64_06630	COG1120	ATPase activity
HIX64_06640	COG2017	converts alpha-aldose to the beta-anomer
HIX64_06665	COG1119	ATPase activity
HIX64_06670	COG2005	Transcriptional regulator
HIX64_06670	COG3585	molybdate ion transport
HIX64_06680	COG0725	ABC transporter, periplasmic molybdate-binding protein
HIX64_06685	COG4149	molybdate abc transporter
HIX64_06695	COG0561	phosphatase activity
HIX64_06705	COG4677	pectinesterase activity
HIX64_06710	COG0582	viral genome integration into host DNA
HIX64_06765	COG4712	double-strand break repair protein
HIX64_06835	COG0305	Participates in initiation and elongation during chromosome replication
HIX64_06895	COG0484	heat shock protein binding
HIX64_06905	COG3772	lysozyme
HIX64_07035	COG1881	PFAM PEBP family protein
HIX64_07085	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIX64_07095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HIX64_07105	COG0670	Belongs to the BI1 family
HIX64_07125	COG0392	lysyltransferase activity
HIX64_07130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIX64_07135	COG3568	Endonuclease Exonuclease Phosphatase
HIX64_07145	COG0842	Transport permease protein
HIX64_07150	COG0842	Transport permease protein
HIX64_07155	COG1131	(ABC) transporter
HIX64_07165	COG1309	transcriptional regulator
HIX64_07170	COG0513	Belongs to the DEAD box helicase family
HIX64_07180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIX64_07195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HIX64_07205	COG0668	transmembrane transport
HIX64_07210	COG1126	abc transporter atp-binding protein
HIX64_07215	COG0765	amino acid transport
HIX64_07220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIX64_07235	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HIX64_07240	COG2194	sulfuric ester hydrolase activity
HIX64_07255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HIX64_07260	COG1376	ErfK ybiS ycfS ynhG family protein
HIX64_07265	COG0488	(ABC) transporter
HIX64_07275	COG0561	phosphatase activity
HIX64_07280	COG1882	Formate acetyltransferase
HIX64_07285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HIX64_07310	COG0747	negative chemotaxis
HIX64_07335	COG2301	Belongs to the HpcH HpaI aldolase family
HIX64_07355	COG1960	acyl-CoA dehydrogenase activity
HIX64_07365	COG0583	DNA-binding transcription factor activity
HIX64_07370	COG2610	gluconate transmembrane transporter activity
HIX64_07385	COG0625	glutathione transferase activity
HIX64_07390	COG1686	Belongs to the peptidase S11 family
HIX64_07395	COG1349	DNA-binding transcription factor activity
HIX64_07400	COG0671	phosphoesterase, PA-phosphatase related
HIX64_07405	COG2814	Major facilitator Superfamily
HIX64_07410	COG0561	phosphatase activity
HIX64_07415	COG0738	Major facilitator superfamily
HIX64_07420	COG3226	Transcriptional regulator
HIX64_07460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HIX64_07465	COG3842	ATPase activity
HIX64_07470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HIX64_07475	COG1177	transmembrane transport
HIX64_07505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIX64_07510	COG4160	amino acid transport
HIX64_07515	COG4215	(ABC) transporter
HIX64_07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIX64_07525	COG1126	abc transporter atp-binding protein
HIX64_07540	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIX64_07545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIX64_07550	COG0702	epimerase
HIX64_07555	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HIX64_07560	COG0028	Belongs to the TPP enzyme family
HIX64_07565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIX64_07575	COG2431	L-lysine efflux transmembrane transporter activity
HIX64_07580	COG3593	DNA synthesis involved in DNA repair
HIX64_07585	COG2990	Protein conserved in bacteria
HIX64_07590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIX64_07595	COG0577	efflux transmembrane transporter activity
HIX64_07595	COG1136	(ABC) transporter
HIX64_07600	COG1278	Cold shock
HIX64_07610	COG0542	response to heat
HIX64_07630	COG1335	isochorismatase
HIX64_07640	COG0583	DNA-binding transcription factor activity
HIX64_07660	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HIX64_07665	COG4988	ABC transporter
HIX64_07670	COG0492	ferredoxin-NADP+ reductase activity
HIX64_07690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HIX64_07700	COG0243	molybdopterin cofactor binding
HIX64_07705	COG0437	4 iron, 4 sulfur cluster binding
HIX64_07710	COG3302	dmso reductase anchor subunit
HIX64_07720	COG0531	amino acid
HIX64_07725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HIX64_07735	COG1882	Formate acetyltransferase
HIX64_07740	COG2116	formate transmembrane transporter activity
HIX64_07745	COG1944	ATP diphosphatase activity
HIX64_07750	COG2323	membrane
HIX64_07765	COG0501	Belongs to the peptidase M48B family
HIX64_07775	COG0539	negative regulation of cytoplasmic translation
HIX64_07785	COG2333	competence protein COMEC
HIX64_07785	COG0658	competence protein
HIX64_07800	COG3214	Protein conserved in bacteria
HIX64_07815	COG3173	Aminoglycoside phosphotransferase
HIX64_07820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HIX64_07825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HIX64_07835	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HIX64_07845	COG2989	Protein conserved in bacteria
HIX64_07850	COG3108	Peptidase M15
HIX64_07855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIX64_07870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HIX64_07880	COG1522	sequence-specific DNA binding
HIX64_07890	COG1115	amino acid carrier protein
HIX64_07900	COG0308	aminopeptidase N
HIX64_07915	COG3217	Mosc domain protein beta barrel domain protein
HIX64_07915	COG0633	Ferredoxin
HIX64_07925	COG0488	(ABC) transporter
HIX64_07930	COG2995	paraquat-inducible protein a
HIX64_07935	COG3008	intermembrane lipid transfer
HIX64_07935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HIX64_07940	COG3009	Protein conserved in bacteria
HIX64_07945	COG3130	regulation of translation
HIX64_07955	COG1067	ATP-dependent peptidase activity
HIX64_07975	COG3070	regulator of competence-specific genes
HIX64_07980	COG1289	transmembrane transporter activity
HIX64_07985	COG3304	Inner membrane component domain
HIX64_07990	COG0210	DNA helicase
HIX64_08005	COG1832	CoA-binding protein
HIX64_08020	COG1881	PFAM PEBP family protein
HIX64_08040	COG0670	Belongs to the BI1 family
HIX64_08085	COG2205	protein histidine kinase activity
HIX64_08090	COG0745	RESPONSE REGULATOR receiver
HIX64_08105	COG2368	4-hydroxyphenylacetate
HIX64_08110	COG1846	Transcriptional regulator
HIX64_08120	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_08125	COG3384	dioxygenase
HIX64_08135	COG3971	2-oxopent-4-enoate hydratase activity
HIX64_08180	COG4232	protein-disulfide reductase activity
HIX64_08185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HIX64_08185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIX64_08190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HIX64_08210	COG3729	General stress protein
HIX64_08215	COG1309	transcriptional regulator
HIX64_08235	COG1702	phosphate starvation-inducible protein PhoH
HIX64_08240	COG1737	Transcriptional regulator
HIX64_08245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIX64_08265	COG2814	Major facilitator Superfamily
HIX64_08270	COG0673	inositol 2-dehydrogenase activity
HIX64_08295	COG3381	protein complex oligomerization
HIX64_08350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIX64_08365	COG2943	transferase activity, transferring hexosyl groups
HIX64_08370	COG5645	(Lipo)protein
HIX64_08385	COG1560	Kdo2-lipid A biosynthetic process
HIX64_08400	COG3038	cytochrome b561
HIX64_08435	COG2999	glutathione oxidoreductase activity
HIX64_08445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HIX64_08535	COG1530	ribonuclease E activity
HIX64_08540	COG0564	pseudouridine synthase activity
HIX64_08585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HIX64_08590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIX64_08595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HIX64_08605	COG0470	DNA polymerase III
HIX64_08610	COG0084	hydrolase, TatD family'
HIX64_08620	COG4773	Receptor
HIX64_08625	COG0537	adenosine 5'-monophosphoramidase activity
HIX64_08630	COG5633	Lipoprotein
HIX64_08655	COG1252	NADH dehydrogenase
HIX64_08660	COG3134	Outer membrane lipoprotein
HIX64_08665	COG1309	transcriptional regulator
HIX64_08675	COG1388	LysM domain
HIX64_08675	COG1376	ErfK ybiS ycfS ynhG family protein
HIX64_08680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIX64_08685	COG4591	ABC-type transport system involved in lipoprotein release permease component
HIX64_08690	COG1136	(ABC) transporter
HIX64_08695	COG4591	ABC-type transport system involved in lipoprotein release permease component
HIX64_08715	COG1177	transmembrane transport
HIX64_08745	COG2850	peptidyl-arginine hydroxylation
HIX64_08760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIX64_08790	COG0538	isocitrate dehydrogenase activity
HIX64_08845	COG0071	Belongs to the small heat shock protein (HSP20) family
HIX64_08855	COG3038	cytochrome b561
HIX64_08865	COG0747	negative chemotaxis
HIX64_08885	COG1124	(ABC) transporter
HIX64_08890	COG0668	transmembrane transport
HIX64_08905	COG3443	Belongs to the bacterial solute-binding protein 9 family
HIX64_08920	COG0789	Transcriptional regulator
HIX64_08930	COG1605	Chorismate mutase
HIX64_08940	COG3615	Tellurite resistance protein tehB
HIX64_08955	COG2261	transglycosylase associated protein
HIX64_08965	COG3042	response to heat
HIX64_08975	COG3189	MarR family transcriptional regulator
HIX64_08980	COG2807	transmembrane transport
HIX64_08985	COG2207	Transcriptional regulator
HIX64_09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIX64_09005	COG2199	diguanylate cyclase activity
HIX64_09020	COG2766	serine protein kinase
HIX64_09025	COG3713	MltA-interacting MipA family protein
HIX64_09030	COG0641	radical SAM
HIX64_09035	COG0656	L-ascorbic acid biosynthetic process
HIX64_09055	COG3139	Protein of unknown function (DUF1315)
HIX64_09060	COG1335	isochorismatase
HIX64_09065	COG0252	asparaginase activity
HIX64_09070	COG0616	signal peptide processing
HIX64_09075	COG0778	Nitroreductase
HIX64_09085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIX64_09100	COG0494	nUDIX hydrolase
HIX64_09125	COG3724	N-succinylarginine dihydrolase activity
HIX64_09135	COG3678	ATP-independent chaperone mediated protein folding
HIX64_09150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIX64_09155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HIX64_09160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HIX64_09165	COG1447	Phosphotransferase system cellobiose-specific component IIA
HIX64_09170	COG1917	Cupin 2, conserved barrel domain protein
HIX64_09170	COG2169	Transcriptional regulator
HIX64_09175	COG1486	melibiose metabolic process
HIX64_09185	COG0753	catalase activity
HIX64_09195	COG1823	symporter activity
HIX64_09200	COG1988	membrane-bound metal-dependent
HIX64_09205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HIX64_09215	COG3001	Fructosamine kinase
HIX64_09225	COG1105	Belongs to the carbohydrate kinase PfkB family
HIX64_09230	COG3137	Salt-induced outer membrane protein
HIX64_09295	COG0386	Belongs to the glutathione peroxidase family
HIX64_09305	COG0791	NLP P60 protein
HIX64_09320	COG4256	Hemin uptake protein
HIX64_09335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIX64_09335	COG0574	Belongs to the PEP-utilizing enzyme family
HIX64_09340	COG0318	PFAM AMP-dependent synthetase and ligase
HIX64_09345	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HIX64_09350	COG0644	oxidoreductase
HIX64_09355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HIX64_09360	COG2086	electron transfer activity
HIX64_09365	COG1917	Cupin 2, conserved barrel domain protein
HIX64_09365	COG2207	Transcriptional regulator
HIX64_09370	COG1960	acyl-CoA dehydrogenase activity
HIX64_09375	COG4670	ketone body catabolic process
HIX64_09390	COG2271	Major facilitator Superfamily
HIX64_09395	COG0738	Major facilitator superfamily
HIX64_09410	COG0628	permease
HIX64_09415	COG0247	lactate metabolic process
HIX64_09415	COG0277	FAD linked oxidase domain protein
HIX64_09420	COG2050	protein possibly involved in aromatic compounds catabolism
HIX64_09430	COG1823	symporter activity
HIX64_09435	COG0316	Belongs to the HesB IscA family
HIX64_09440	COG0719	Fe-S assembly protein
HIX64_09445	COG0396	ATPase activity
HIX64_09450	COG0719	Fe-S assembly protein
HIX64_09465	COG1376	ErfK ybiS ycfS ynhG family protein
HIX64_09485	COG0531	amino acid
HIX64_09490	COG2267	carboxylic ester hydrolase activity
HIX64_09500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_09535	COG3272	Protein of unknown function (DUF1722)
HIX64_09540	COG0789	Transcriptional regulator
HIX64_09720	COG0307	riboflavin synthase, alpha
HIX64_09725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIX64_09730	COG2814	Major facilitator Superfamily
HIX64_09735	COG0583	DNA-binding transcription factor activity
HIX64_09755	COG0791	NLP P60 protein
HIX64_09760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HIX64_09775	COG1902	pentaerythritol trinitrate reductase activity
HIX64_09780	COG1309	transcriptional regulator
HIX64_09785	COG3313	Fe-S protein
HIX64_09790	COG4989	oxidoreductase activity
HIX64_09805	COG1566	PFAM secretion protein HlyD family protein
HIX64_09830	COG3895	Periplasmic Protein
HIX64_09850	COG0625	glutathione transferase activity
HIX64_09860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIX64_09910	COG0673	inositol 2-dehydrogenase activity
HIX64_09920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HIX64_09925	COG1263	PTS System
HIX64_09925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HIX64_09930	COG1609	Transcriptional regulator
HIX64_09935	COG5339	Protein conserved in bacteria
HIX64_09960	COG2205	protein histidine kinase activity
HIX64_09965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HIX64_09970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HIX64_09975	COG0745	RESPONSE REGULATOR receiver
HIX64_09980	COG3136	membrane protein required for alginate biosynthesis
HIX64_09985	COG0531	amino acid
HIX64_09995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HIX64_10000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HIX64_10005	COG0628	permease
HIX64_10020	COG3591	Belongs to the peptidase S1B family
HIX64_10030	COG2814	Major facilitator Superfamily
HIX64_10035	COG0583	DNA-binding transcription factor activity
HIX64_10040	COG1940	carbohydrate kinase activity
HIX64_10080	COG3302	dmso reductase anchor subunit
HIX64_10085	COG0437	4 iron, 4 sulfur cluster binding
HIX64_10090	COG0243	molybdopterin cofactor binding
HIX64_10095	COG0243	molybdopterin cofactor binding
HIX64_10110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HIX64_10130	COG1063	alcohol dehydrogenase
HIX64_10135	COG0477	Major facilitator Superfamily
HIX64_10140	COG0246	Mannitol dehydrogenase
HIX64_10150	COG1802	Transcriptional regulator
HIX64_10155	COG4221	oxidoreductase activity
HIX64_10165	COG3729	General stress protein
HIX64_10170	COG1546	Belongs to the CinA family
HIX64_10175	COG3111	PFAM Bacterial OB fold (BOF) protein
HIX64_10185	COG2814	Major facilitator Superfamily
HIX64_10220	COG0583	DNA-binding transcription factor activity
HIX64_10225	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_10240	COG3781	membrane
HIX64_10265	COG1773	rubredoxin
HIX64_10290	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HIX64_10295	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HIX64_10305	COG2186	Transcriptional regulator
HIX64_10310	COG1063	alcohol dehydrogenase
HIX64_10315	COG2271	Major facilitator Superfamily
HIX64_10340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HIX64_10345	COG0251	oxidation-reduction process
HIX64_10395	COG1609	Transcriptional regulator
HIX64_10400	COG1757	Na H antiporter
HIX64_10405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HIX64_10420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HIX64_10435	COG1764	response to oxidative stress
HIX64_10455	COG1064	alcohol dehydrogenase
HIX64_10460	COG2864	formate dehydrogenase
HIX64_10465	COG0437	4 iron, 4 sulfur cluster binding
HIX64_10505	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HIX64_10510	COG1140	nitrate reductase beta subunit
HIX64_10515	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HIX64_10520	COG2181	nitrate reductase activity
HIX64_10555	COG4772	TonB-dependent receptor
HIX64_10560	COG1802	Transcriptional regulator
HIX64_10565	COG2130	NADP-dependent
HIX64_10575	COG3238	Protein conserved in bacteria
HIX64_10615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIX64_10620	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HIX64_10645	COG0826	peptidase U32
HIX64_10650	COG1396	sequence-specific DNA binding
HIX64_10655	COG3135	benzoate transporter
HIX64_10665	COG0500	methyltransferase
HIX64_10670	COG1275	C4-dicarboxylate transporter malic acid transport protein
HIX64_10675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HIX64_10680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HIX64_10695	COG3775	system Galactitol-specific IIC component
HIX64_10700	COG0434	BtpA family
HIX64_10705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_10710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIX64_10715	COG1349	DNA-binding transcription factor activity
HIX64_10725	COG1304	FMN binding
HIX64_10730	COG2353	YceI-like domain
HIX64_10740	COG2272	Belongs to the type-B carboxylesterase lipase family
HIX64_10745	COG5383	Protein conserved in bacteria
HIX64_10750	COG0583	DNA-binding transcription factor activity
HIX64_10755	COG0840	transmembrane signaling receptor activity
HIX64_10790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIX64_10795	COG0765	amino acid transport
HIX64_10800	COG1126	abc transporter atp-binding protein
HIX64_10805	COG0765	amino acid transport
HIX64_10815	COG0500	methyltransferase
HIX64_10820	COG3038	cytochrome b561
HIX64_10825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HIX64_10830	COG1643	Atp-dependent helicase
HIX64_10845	COG3784	Protein of unknown function (DUF1318)
HIX64_10855	COG2911	Protein conserved in bacteria
HIX64_10860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HIX64_10865	COG3187	Heat shock protein
HIX64_10870	COG3042	response to heat
HIX64_10880	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HIX64_10880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIX64_10880	COG0674	pyruvate-flavodoxin oxidoreductase activity
HIX64_10880	COG1013	pyruvate-flavodoxin oxidoreductase activity
HIX64_10890	COG2076	Multidrug Resistance protein
HIX64_10905	COG0513	Belongs to the DEAD box helicase family
HIX64_10915	COG0840	transmembrane signaling receptor activity
HIX64_10920	COG2840	Smr protein MutS2
HIX64_10940	COG3182	Iron-regulated membrane protein
HIX64_10945	COG0668	transmembrane transport
HIX64_10965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HIX64_11000	COG1309	transcriptional regulator
HIX64_11005	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_11010	COG0656	L-ascorbic acid biosynthetic process
HIX64_11015	COG0583	DNA-binding transcription factor activity
HIX64_11025	COG4166	transmembrane transport
HIX64_11030	COG2866	Carboxypeptidase
HIX64_11035	COG4948	Mandelate Racemase Muconate Lactonizing
HIX64_11055	COG3106	COG3106 Predicted ATPase
HIX64_11060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIX64_11070	COG1983	PspC domain protein
HIX64_11080	COG1842	Phage shock protein A
HIX64_11085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HIX64_11140	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIX64_11140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIX64_11150	COG5001	Diguanylate cyclase
HIX64_11160	COG1349	DNA-binding transcription factor activity
HIX64_11180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HIX64_11185	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HIX64_11190	COG0671	phosphoesterase, PA-phosphatase related
HIX64_11225	COG0616	signal peptide processing
HIX64_11230	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_11245	COG0009	L-threonylcarbamoyladenylate synthase
HIX64_11285	COG3729	General stress protein
HIX64_11290	COG3685	Protein conserved in bacteria
HIX64_11295	COG3685	Protein conserved in bacteria
HIX64_11310	COG0727	PFAM Uncharacterised protein family (UPF0153)
HIX64_11335	COG2350	Protein conserved in bacteria
HIX64_11355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIX64_11385	COG2095	MarC family integral membrane protein
HIX64_11390	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_11390	COG1454	alcohol dehydrogenase
HIX64_11405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HIX64_11410	COG0745	RESPONSE REGULATOR receiver
HIX64_11415	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIX64_11425	COG0788	formyltetrahydrofolate deformylase activity
HIX64_11465	COG2181	nitrate reductase activity
HIX64_11470	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HIX64_11475	COG1140	nitrate reductase beta subunit
HIX64_11480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HIX64_11485	COG2223	nitrite transmembrane transporter activity
HIX64_11490	COG3850	Histidine kinase
HIX64_11495	COG2197	response regulator
HIX64_11500	COG4932	domain protein
HIX64_11505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HIX64_11510	COG4572	Cation transport regulator
HIX64_11515	COG0387	Pfam Sodium calcium exchanger
HIX64_11565	COG0659	secondary active sulfate transmembrane transporter activity
HIX64_11580	COG0012	GTP binding
HIX64_11595	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HIX64_11605	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HIX64_11610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HIX64_11615	COG1999	signal sequence binding
HIX64_11620	COG1773	rubredoxin
HIX64_11625	COG1271	oxidase subunit
HIX64_11630	COG1294	oxidase, subunit
HIX64_11640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIX64_11665	COG1619	proteins homologs of microcin C7 resistance protein MccF
HIX64_11685	COG2719	SpoVR family
HIX64_11725	COG0179	Fumarylacetoacetate (FAA) hydrolase
HIX64_11740	COG2894	cell division
HIX64_11750	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HIX64_11760	COG3065	identical protein binding
HIX64_11770	COG1199	ATP-dependent helicase activity
HIX64_11775	COG0251	oxidation-reduction process
HIX64_11795	COG1760	l-serine dehydratase
HIX64_11800	COG2200	EAL domain
HIX64_11805	COG1253	flavin adenine dinucleotide binding
HIX64_11810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HIX64_11810	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_11815	COG3715	PTS system
HIX64_11820	COG3716	PTS system mannose fructose sorbose family IID component
HIX64_11835	COG2226	methyltransferase
HIX64_11840	COG0768	penicillin binding
HIX64_11870	COG1414	Transcriptional regulator
HIX64_11875	COG2814	Major facilitator Superfamily
HIX64_11895	COG1956	GAF domain-containing protein
HIX64_11900	COG2995	paraquat-inducible protein a
HIX64_11905	COG3008	intermembrane lipid transfer
HIX64_11940	COG5562	phage envelope protein
HIX64_11950	COG0454	-acetyltransferase
HIX64_11965	COG3328	transposase activity
HIX64_12050	COG1276	copper resistance
HIX64_12055	COG2372	response to copper ion
HIX64_12065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIX64_12070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIX64_12075	COG1770	oligopeptidase
HIX64_12080	COG2979	Protein of unknown function (DUF533)
HIX64_12090	COG3141	response to X-ray
HIX64_12100	COG0800	Aldolase
HIX64_12105	COG0129	dihydroxy-acid dehydratase activity
HIX64_12110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HIX64_12115	COG1737	Transcriptional regulator
HIX64_12125	COG1560	Kdo2-lipid A biosynthetic process
HIX64_12130	COG0739	heme binding
HIX64_12135	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HIX64_12145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIX64_12185	COG0494	nUDIX hydrolase
HIX64_12195	COG1335	isochorismatase
HIX64_12200	COG1801	Protein of unknown function DUF72
HIX64_12205	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HIX64_12225	COG3102	Protein conserved in bacteria
HIX64_12240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HIX64_12345	COG1528	Iron-storage protein
HIX64_12360	COG1528	Iron-storage protein
HIX64_12370	COG0814	amino acid
HIX64_12375	COG3318	Belongs to the UPF0149 family
HIX64_12375	COG3012	SEC-C Motif Domain Protein
HIX64_12420	COG2197	response regulator
HIX64_12435	COG2197	response regulator
HIX64_12440	COG1126	abc transporter atp-binding protein
HIX64_12445	COG0765	amino acid transport
HIX64_12455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIX64_12510	COG0425	Belongs to the sulfur carrier protein TusA family
HIX64_12615	COG5475	Uncharacterized small protein (DUF2158)
HIX64_12620	COG2354	Protein conserved in bacteria
HIX64_12625	COG0697	spore germination
HIX64_12630	COG3727	T/G mismatch-specific endonuclease activity
HIX64_12635	COG0270	DNA (cytosine-5-)-methyltransferase activity
HIX64_12640	COG1418	mRNA catabolic process
HIX64_12650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HIX64_12730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIX64_12755	COG0534	Mate efflux family protein
HIX64_12790	COG1122	ATPase activity
HIX64_12920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HIX64_12935	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HIX64_12950	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_12950	COG1454	alcohol dehydrogenase
HIX64_12990	COG1289	transmembrane transporter activity
HIX64_13030	COG2925	Exonuclease
HIX64_13035	COG0531	amino acid
HIX64_13045	COG0583	DNA-binding transcription factor activity
HIX64_13050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIX64_13135	COG0438	transferase activity, transferring glycosyl groups
HIX64_13165	COG2327	Polysaccharide pyruvyl transferase
HIX64_13170	COG2244	polysaccharide biosynthetic process
HIX64_13175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HIX64_13190	COG0297	glycogen (starch) synthase activity
HIX64_13200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIX64_13205	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HIX64_13210	COG0110	maltose O-acetyltransferase activity
HIX64_13215	COG1216	Glycosyl transferase, family 2
HIX64_13225	COG0438	transferase activity, transferring glycosyl groups
HIX64_13235	COG0463	Glycosyl transferase, family 2
HIX64_13255	COG1253	flavin adenine dinucleotide binding
HIX64_13260	COG2982	Protein involved in outer membrane biogenesis
HIX64_13275	COG5001	Diguanylate cyclase
HIX64_13275	COG3447	MASE1 domain protein
HIX64_13275	COG5002	protein histidine kinase activity
HIX64_13280	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HIX64_13285	COG0443	Heat shock 70 kDa protein
HIX64_13315	COG2205	protein histidine kinase activity
HIX64_13320	COG0745	RESPONSE REGULATOR receiver
HIX64_13340	COG0826	peptidase U32
HIX64_13365	COG1830	Aldolase
HIX64_13370	COG2211	Major facilitator Superfamily
HIX64_13375	COG1397	ADP-ribosylglycohydrolase
HIX64_13380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_13385	COG2188	Transcriptional regulator
HIX64_13400	COG5455	response to cobalt ion
HIX64_13410	COG3188	usher protein
HIX64_13415	COG3121	Chaperone
HIX64_13440	COG4808	Protein conserved in bacteria
HIX64_13445	COG4808	Protein conserved in bacteria
HIX64_13450	COG4807	Protein conserved in bacteria
HIX64_13460	COG3275	phosphorelay sensor kinase activity
HIX64_13475	COG1174	glycine betaine transport
HIX64_13480	COG1125	glycine betaine transport
HIX64_13485	COG1174	glycine betaine transport
HIX64_13490	COG1732	Glycine betaine
HIX64_13500	COG0277	FAD linked oxidase domain protein
HIX64_13505	COG1686	Belongs to the peptidase S11 family
HIX64_13515	COG0586	Pfam SNARE associated Golgi protein
HIX64_13520	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_13525	COG1538	Outer membrane efflux protein
HIX64_13540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIX64_13545	COG0625	glutathione transferase activity
HIX64_13560	COG2271	Major facilitator Superfamily
HIX64_13575	COG1346	cytolysis
HIX64_13585	COG2949	membrane
HIX64_13625	COG2311	Membrane
HIX64_13645	COG1760	l-serine dehydratase
HIX64_13650	COG3830	Belongs to the UPF0237 family
HIX64_13650	COG0560	Phosphoserine phosphatase
HIX64_13655	COG2271	Major facilitator Superfamily
HIX64_13660	COG4771	TonB-dependent receptor
HIX64_13665	COG0833	amino acid
HIX64_13670	COG0583	DNA-binding transcription factor activity
HIX64_13675	COG2855	membrane
HIX64_13685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIX64_13685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIX64_13685	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HIX64_13690	COG1105	Belongs to the carbohydrate kinase PfkB family
HIX64_13725	COG0523	cobalamin synthesis protein
HIX64_13730	COG0671	phosphoesterase, PA-phosphatase related
HIX64_13735	COG0791	NLP P60 protein
HIX64_13740	COG2200	EAL domain
HIX64_13745	COG4166	transmembrane transport
HIX64_13750	COG4174	ABC transporter (Permease)
HIX64_13755	COG4239	(ABC) transporter, permease
HIX64_13760	COG4172	Belongs to the ABC transporter superfamily
HIX64_13770	COG2814	Major facilitator Superfamily
HIX64_13780	COG1061	Type III restriction enzyme res subunit
HIX64_13830	COG5301	cellulose 1,4-beta-cellobiosidase activity
HIX64_13850	COG2197	response regulator
HIX64_13860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HIX64_13870	COG1138	Cytochrome C-type biogenesis protein
HIX64_13880	COG1138	Cytochrome C-type biogenesis protein
HIX64_13890	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HIX64_13910	COG3005	denitrification pathway
HIX64_13915	COG3043	anaerobic respiration
HIX64_13920	COG0348	domain, Protein
HIX64_13925	COG0437	4 iron, 4 sulfur cluster binding
HIX64_13935	COG3062	negative regulation of establishment of protein localization
HIX64_13940	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_13940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_13950	COG4615	Cyclic peptide transporter
HIX64_13975	COG0642	Histidine kinase
HIX64_13975	COG2198	Histidine kinase
HIX64_13995	COG4948	Mandelate Racemase Muconate Lactonizing
HIX64_14025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIX64_14030	COG2814	Major facilitator Superfamily
HIX64_14035	COG0583	DNA-binding transcription factor activity
HIX64_14040	COG0584	glycerophosphoryl diester phosphodiesterase
HIX64_14045	COG2271	Major facilitator Superfamily
HIX64_14050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HIX64_14060	COG0247	lactate metabolic process
HIX64_14065	COG5160	protein modification by small protein removal
HIX64_14080	COG2271	Major facilitator Superfamily
HIX64_14090	COG1414	Transcriptional regulator
HIX64_14180	COG1169	isochorismate synthase
HIX64_14185	COG4575	ribosome binding
HIX64_14190	COG2153	protein acetylation
HIX64_14200	COG0784	Response regulator, receiver
HIX64_14200	COG0835	chemotaxis
HIX64_14205	COG2304	oxidoreductase activity
HIX64_14220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIX64_14225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIX64_14235	COG0839	Belongs to the complex I subunit 6 family
HIX64_14285	COG0583	DNA-binding transcription factor activity
HIX64_14290	COG0436	Aminotransferase
HIX64_14300	COG0471	metal ion transport
HIX64_14300	COG0490	domain, Protein
HIX64_14305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HIX64_14330	COG1288	antiporter activity
HIX64_14335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HIX64_14340	COG3959	Transketolase, thiamine diphosphate binding domain
HIX64_14345	COG3037	sugar-specific permease SgaT UlaA
HIX64_14355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_14360	COG1609	Transcriptional regulator
HIX64_14370	COG0622	Phosphoesterase
HIX64_14375	COG0625	glutathione transferase activity
HIX64_14380	COG0625	glutathione transferase activity
HIX64_14385	COG1090	epimerase
HIX64_14420	COG0833	amino acid
HIX64_14425	COG3457	Alanine racemase
HIX64_14430	COG0531	amino acid
HIX64_14440	COG3829	transcription factor binding
HIX64_14445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIX64_14450	COG1286	toxin biosynthetic process
HIX64_14455	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HIX64_14460	COG0285	dihydrofolate synthase activity
HIX64_14470	COG0586	Pfam SNARE associated Golgi protein
HIX64_14480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HIX64_14505	COG3423	Transcriptional regulator
HIX64_14525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HIX64_14540	COG3101	peptidyl-lysine hydroxylation
HIX64_14545	COG0730	response to heat
HIX64_14570	COG2062	phosphohistidine phosphatase, SixA
HIX64_14585	COG3691	Protein conserved in bacteria
HIX64_14600	COG2116	formate transmembrane transporter activity
HIX64_14610	COG0582	viral genome integration into host DNA
HIX64_14765	COG3772	lysozyme
HIX64_14775	COG0484	heat shock protein binding
HIX64_14835	COG0305	Participates in initiation and elongation during chromosome replication
HIX64_14900	COG4712	double-strand break repair protein
HIX64_14990	COG1560	Kdo2-lipid A biosynthetic process
HIX64_15000	COG0436	Aminotransferase
HIX64_15015	COG3961	Belongs to the TPP enzyme family
HIX64_15035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HIX64_15040	COG2199	diguanylate cyclase activity
HIX64_15040	COG2200	EAL domain
HIX64_15055	COG3415	Transposase
HIX64_15060	COG3415	Transposase
HIX64_15090	COG0583	DNA-binding transcription factor activity
HIX64_15100	COG2211	Major facilitator Superfamily
HIX64_15105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HIX64_15115	COG0583	DNA-binding transcription factor activity
HIX64_15120	COG0385	Bile acid
HIX64_15125	COG3530	Putative quorum-sensing-regulated virulence factor
HIX64_15150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_15200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HIX64_15205	COG4208	sulfate ABC transporter
HIX64_15225	COG2837	iron assimilation
HIX64_15360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HIX64_15370	COG5342	invasion associated locus B
HIX64_15385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_15385	COG0493	'glutamate synthase
HIX64_15390	COG3850	Histidine kinase
HIX64_15395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIX64_15405	COG1393	Belongs to the ArsC family
HIX64_15425	COG2321	neutral zinc metallopeptidase
HIX64_15435	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HIX64_15440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIX64_15445	COG2716	regulation of RNA biosynthetic process
HIX64_15450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HIX64_15455	COG1929	Belongs to the glycerate kinase type-1 family
HIX64_15460	COG2610	gluconate transmembrane transporter activity
HIX64_15465	COG3835	regulator
HIX64_15470	COG0628	permease
HIX64_15480	COG1393	Belongs to the ArsC family
HIX64_15490	COG2233	PERMEase
HIX64_15505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIX64_15520	COG2200	EAL domain
HIX64_15560	COG0517	IMP dehydrogenase activity
HIX64_15560	COG0516	GMP reductase activity
HIX64_15600	COG1645	bacterial-type flagellum-dependent swarming motility
HIX64_15615	COG2976	Protein conserved in bacteria
HIX64_15655	COG0437	4 iron, 4 sulfur cluster binding
HIX64_15660	COG0243	molybdopterin cofactor binding
HIX64_15665	COG4953	penicillin-binding protein 1C
HIX64_15670	COG2373	Large extracellular alpha-helical protein
HIX64_15675	COG2897	thiosulfate sulfurtransferase activity
HIX64_15700	COG2975	iron-sulfur cluster assembly
HIX64_15705	COG0633	Ferredoxin
HIX64_15725	COG0822	iron-sulfur transferase activity
HIX64_15770	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HIX64_15780	COG3711	transcriptional antiterminator
HIX64_15785	COG2814	Major facilitator Superfamily
HIX64_15795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIX64_15795	COG1017	nitric oxide dioxygenase activity
HIX64_15800	COG3710	Transcriptional regulator
HIX64_15805	COG0531	amino acid
HIX64_15815	COG3104	oligopeptide transport
HIX64_15820	COG0347	Belongs to the P(II) protein family
HIX64_15825	COG2204	response regulator
HIX64_15830	COG3170	Tfp pilus assembly protein FimV
HIX64_15835	COG2205	protein histidine kinase activity
HIX64_15860	COG0560	Phosphoserine phosphatase
HIX64_15865	COG1263	PTS System
HIX64_15865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HIX64_15875	COG1737	Transcriptional regulator
HIX64_15880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HIX64_15885	COG2223	nitrite transmembrane transporter activity
HIX64_15890	COG0583	DNA-binding transcription factor activity
HIX64_15895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_15935	COG3086	response to oxidative stress
HIX64_15970	COG0513	Belongs to the DEAD box helicase family
HIX64_15975	COG0583	DNA-binding transcription factor activity
HIX64_15995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIX64_16000	COG3118	belongs to the thioredoxin family
HIX64_16005	COG3148	PFAM DTW domain containing protein
HIX64_16015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIX64_16020	COG5544	Lipoprotein
HIX64_16025	COG0477	Major facilitator Superfamily
HIX64_16055	COG0542	response to heat
HIX64_16070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIX64_16075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HIX64_16085	COG0077	Prephenate dehydratase
HIX64_16085	COG1605	Chorismate mutase
HIX64_16095	COG0287	Prephenate dehydrogenase
HIX64_16095	COG1605	Chorismate mutase
HIX64_16110	COG2199	diguanylate cyclase activity
HIX64_16135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIX64_16140	COG4137	Cytochrome C assembly protein
HIX64_16145	COG4536	flavin adenine dinucleotide binding
HIX64_16165	COG0497	DNA recombination
HIX64_16180	COG2867	negative regulation of translational initiation
HIX64_16205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIX64_16215	COG0582	viral genome integration into host DNA
HIX64_16300	COG2819	hydrolase of the alpha beta superfamily
HIX64_16320	COG2990	Protein conserved in bacteria
HIX64_16330	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HIX64_16365	COG0579	oxidoreductase
HIX64_16370	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_16375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIX64_16380	COG1113	amino acid transport
HIX64_16385	COG1802	Transcriptional regulator
HIX64_16390	COG1652	LysM domain
HIX64_16395	COG0401	homolog of Blt101
HIX64_16400	COG0640	Transcriptional regulator
HIX64_16405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIX64_16430	COG4575	ribosome binding
HIX64_16440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIX64_16480	COG2814	Major facilitator Superfamily
HIX64_16485	COG1846	Transcriptional regulator
HIX64_16490	COG1566	PFAM secretion protein HlyD family protein
HIX64_16495	COG2814	Major facilitator Superfamily
HIX64_16515	COG1238	metal cluster binding
HIX64_16520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HIX64_16540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HIX64_16560	COG1546	Belongs to the CinA family
HIX64_16565	COG2951	lytic endotransglycosylase activity
HIX64_16570	COG3730	PTS system glucitol sorbitol-specific
HIX64_16575	COG3732	PTS system glucitol sorbitol-specific
HIX64_16585	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_16590	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_16595	COG1349	DNA-binding transcription factor activity
HIX64_16600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HIX64_16600	COG0517	IMP dehydrogenase activity
HIX64_16620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HIX64_16625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_16635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HIX64_16645	COG3260	NADH ubiquinone oxidoreductase 20
HIX64_16650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIX64_16655	COG3261	NADH dehydrogenase
HIX64_16655	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HIX64_16660	COG0650	Formate hydrogenlyase subunit 4
HIX64_16665	COG0651	ATP synthesis coupled electron transport
HIX64_16670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_16685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HIX64_16690	COG0298	carbon dioxide binding
HIX64_16695	COG0409	Hydrogenase expression formation protein
HIX64_16700	COG0309	Hydrogenase expression formation protein (HypE)
HIX64_16720	COG1121	(ABC) transporter
HIX64_16725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIX64_16730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIX64_16815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIX64_16905	COG2207	Transcriptional regulator
HIX64_16970	COG0477	Major facilitator Superfamily
HIX64_16980	COG2610	gluconate transmembrane transporter activity
HIX64_16985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIX64_16990	COG3622	Belongs to the hyi family
HIX64_16995	COG0235	Class ii aldolase
HIX64_17005	COG2084	Dehydrogenase
HIX64_17010	COG1349	DNA-binding transcription factor activity
HIX64_17020	COG0163	prenyltransferase activity
HIX64_17025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HIX64_17040	COG4942	peptidase
HIX64_17040	COG1388	LysM domain
HIX64_17095	COG2234	aminopeptidase activity
HIX64_17100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIX64_17105	COG1518	maintenance of DNA repeat elements
HIX64_17120	COG1857	crispr-associated protein
HIX64_17135	COG1203	CRISPR-associated helicase, Cas3
HIX64_17160	COG0720	synthase
HIX64_17165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HIX64_17165	COG0321	lipoyl(octanoyl) transferase activity
HIX64_17170	COG0602	queuosine metabolic process
HIX64_17185	COG3956	TIGRFAM MazG family protein
HIX64_17195	COG3609	addiction module antidote protein, CC2985 family
HIX64_17200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIX64_17210	COG2205	protein histidine kinase activity
HIX64_17210	COG3437	response regulator, receiver
HIX64_17210	COG3850	Histidine kinase
HIX64_17210	COG4999	Histidine kinase
HIX64_17215	COG1929	Belongs to the glycerate kinase type-1 family
HIX64_17220	COG4948	Mandelate Racemase Muconate Lactonizing
HIX64_17225	COG4948	Mandelate Racemase Muconate Lactonizing
HIX64_17230	COG2271	Major facilitator Superfamily
HIX64_17240	COG0716	FMN binding
HIX64_17250	COG3098	single-species biofilm formation
HIX64_17265	COG1611	Belongs to the LOG family
HIX64_17270	COG0814	amino acid
HIX64_17275	COG1760	l-serine dehydratase
HIX64_17280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIX64_17285	COG1454	alcohol dehydrogenase
HIX64_17290	COG0235	Class ii aldolase
HIX64_17295	COG0738	Major facilitator superfamily
HIX64_17315	COG1349	DNA-binding transcription factor activity
HIX64_17325	COG2363	Small membrane protein
HIX64_17330	COG0583	DNA-binding transcription factor activity
HIX64_17340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIX64_17345	COG2166	iron-sulfur cluster assembly
HIX64_17350	COG2962	Rard protein
HIX64_17355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HIX64_17360	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HIX64_17375	COG0860	N-Acetylmuramoyl-L-alanine amidase
HIX64_17385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIX64_17390	COG1074	ATP-dependent DNA helicase activity
HIX64_17400	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HIX64_17405	COG4967	type IV pilus modification protein PilV
HIX64_17415	COG4795	General secretion pathway protein
HIX64_17420	COG2165	general secretion pathway protein
HIX64_17450	COG0861	Integral membrane protein TerC family
HIX64_17460	COG0667	Aldo Keto reductase
HIX64_17480	COG1609	Transcriptional regulator
HIX64_17490	COG0583	DNA-binding transcription factor activity
HIX64_17495	COG1794	racemase activity, acting on amino acids and derivatives
HIX64_17500	COG2814	Major facilitator Superfamily
HIX64_17505	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_17515	COG0183	Belongs to the thiolase family
HIX64_17530	COG0814	amino acid
HIX64_17565	COG3188	usher protein
HIX64_17585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HIX64_17590	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_17595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIX64_17600	COG3775	system Galactitol-specific IIC component
HIX64_17605	COG3414	Phosphotransferase system galactitol-specific IIB component
HIX64_17610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_17615	COG1349	DNA-binding transcription factor activity
HIX64_17620	COG0698	ribose 5-phosphate isomerase
HIX64_17625	COG3775	system Galactitol-specific IIC component
HIX64_17630	COG3414	Phosphotransferase system galactitol-specific IIB component
HIX64_17635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_17635	COG2213	PTS system mannitol-specific
HIX64_17655	COG0582	viral genome integration into host DNA
HIX64_17665	COG4942	peptidase
HIX64_17720	COG1272	protein, Hemolysin III
HIX64_17730	COG2723	6-phospho-beta-galactosidase activity
HIX64_17755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIX64_17760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIX64_17765	COG0006	proline dipeptidase activity
HIX64_17785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIX64_17790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HIX64_17805	COG2968	Membrane
HIX64_17815	COG0668	transmembrane transport
HIX64_17820	COG0191	fructose-bisphosphate aldolase activity
HIX64_17850	COG1122	ATPase activity
HIX64_17855	COG1122	ATPase activity
HIX64_17860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HIX64_17865	COG0501	Belongs to the peptidase M48B family
HIX64_17880	COG2731	YhcH YjgK YiaL family protein
HIX64_17885	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HIX64_17890	COG1063	alcohol dehydrogenase
HIX64_17895	COG0246	Mannitol dehydrogenase
HIX64_17905	COG2186	Transcriptional regulator
HIX64_17915	COG1166	arginine decarboxylase activity
HIX64_17940	COG2814	Major facilitator Superfamily
HIX64_17950	COG2356	endonuclease I
HIX64_17955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIX64_17980	COG2805	Type II/IV secretion system protein
HIX64_17985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HIX64_17990	COG0762	integral membrane protein
HIX64_18005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HIX64_18015	COG0252	asparaginase activity
HIX64_18025	COG3171	Protein conserved in bacteria
HIX64_18050	COG2211	Major facilitator Superfamily
HIX64_18055	COG1982	Orn Lys Arg decarboxylase major
HIX64_18060	COG1811	Na channel or pump
HIX64_18080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HIX64_18090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIX64_18140	COG0427	acetyl-CoA hydrolase
HIX64_18145	COG2030	dehydratase
HIX64_18150	COG2301	Belongs to the HpcH HpaI aldolase family
HIX64_18180	COG0531	amino acid
HIX64_18190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIX64_18195	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_18220	COG2271	Major facilitator Superfamily
HIX64_18230	COG0246	Mannitol dehydrogenase
HIX64_18245	COG0754	glutathionylspermidine amidase activity
HIX64_18250	COG0625	glutathione transferase activity
HIX64_18260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HIX64_18265	COG0298	carbon dioxide binding
HIX64_18275	COG1773	rubredoxin
HIX64_18280	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HIX64_18285	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HIX64_18290	COG5557	Pfam Polysulphide reductase, NrfD
HIX64_18295	COG0437	4 iron, 4 sulfur cluster binding
HIX64_18300	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HIX64_18310	COG0840	transmembrane signaling receptor activity
HIX64_18335	COG1028	Short-chain dehydrogenase reductase Sdr
HIX64_18340	COG0848	biopolymer transport protein
HIX64_18360	COG2207	Transcriptional regulator
HIX64_18365	COG1979	alcohol dehydrogenase
HIX64_18375	COG0471	metal ion transport
HIX64_18425	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HIX64_18430	COG3111	PFAM Bacterial OB fold (BOF) protein
HIX64_18445	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIX64_18450	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HIX64_18460	COG3150	esterase
HIX64_18465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIX64_18470	COG3151	Protein conserved in bacteria
HIX64_18475	COG0494	nUDIX hydrolase
HIX64_18490	COG0754	glutathionylspermidine amidase activity
HIX64_18495	COG3384	dioxygenase
HIX64_18540	COG1585	Membrane protein implicated in regulation of membrane protease activity
HIX64_18545	COG2268	Band 7 protein
HIX64_18565	COG3025	triphosphatase activity
HIX64_18570	COG4991	sh3 domain protein
HIX64_18585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HIX64_18610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HIX64_18635	COG2375	cellular response to nickel ion
HIX64_18640	COG1695	Transcriptional regulator
HIX64_18645	COG0840	transmembrane signaling receptor activity
HIX64_18650	COG0840	transmembrane signaling receptor activity
HIX64_18660	COG1902	pentaerythritol trinitrate reductase activity
HIX64_18660	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIX64_18670	COG1451	nucleotide metabolic process
HIX64_18675	COG2949	membrane
HIX64_18680	COG0673	inositol 2-dehydrogenase activity
HIX64_18695	COG0586	Pfam SNARE associated Golgi protein
HIX64_18705	COG1422	Protein of unknown function (DUF1090)
HIX64_18710	COG4575	ribosome binding
HIX64_18715	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HIX64_18725	COG2259	Doxx family
HIX64_18730	COG0435	Glutathione S-transferase
HIX64_18735	COG3152	Membrane
HIX64_18740	COG0583	DNA-binding transcription factor activity
HIX64_18745	COG1741	Belongs to the pirin family
HIX64_18760	COG0814	amino acid
HIX64_18765	COG1760	l-serine dehydratase
HIX64_18770	COG1882	Formate acetyltransferase
HIX64_18790	COG0583	DNA-binding transcription factor activity
HIX64_18805	COG1929	Belongs to the glycerate kinase type-1 family
HIX64_18810	COG2084	Dehydrogenase
HIX64_18820	COG2721	sulfolactate sulfo-lyase activity
HIX64_18835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_18840	COG3414	Phosphotransferase system galactitol-specific IIB component
HIX64_18845	COG3775	system Galactitol-specific IIC component
HIX64_18850	COG1063	alcohol dehydrogenase
HIX64_18860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HIX64_18865	COG3107	peptidoglycan biosynthetic process
HIX64_18880	COG2823	Periplasmic or secreted lipoprotein
HIX64_18885	COG0702	epimerase
HIX64_18890	COG0693	protein deglycase activity
HIX64_18905	COG3153	acetyltransferase
HIX64_18910	COG3154	lipid carrier protein
HIX64_18915	COG0826	peptidase U32
HIX64_18920	COG0826	peptidase U32
HIX64_18925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIX64_18930	COG0814	amino acid
HIX64_18935	COG0513	Belongs to the DEAD box helicase family
HIX64_19005	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HIX64_19015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HIX64_19030	COG1534	Rna-binding protein
HIX64_19040	COG2027	D-alanyl-D-alanine carboxypeptidase
HIX64_19055	COG0697	spore germination
HIX64_19070	COG0142	geranyltranstransferase activity
HIX64_19075	COG3423	Transcriptional regulator
HIX64_19085	COG5007	Belongs to the BolA IbaG family
HIX64_19090	COG3113	response to antibiotic
HIX64_19095	COG2854	intermembrane phospholipid transfer
HIX64_19100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HIX64_19105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HIX64_19110	COG1127	ABC transporter
HIX64_19115	COG0530	calcium, potassium:sodium antiporter activity
HIX64_19125	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HIX64_19130	COG3117	lipopolysaccharide transmembrane transporter activity
HIX64_19135	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HIX64_19140	COG1137	ATPase activity
HIX64_19165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_19170	COG0515	serine threonine protein kinase
HIX64_19180	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HIX64_19185	COG5002	protein histidine kinase activity
HIX64_19185	COG0784	Response regulator, receiver
HIX64_19185	COG2198	Histidine kinase
HIX64_19190	COG1242	4 iron, 4 sulfur cluster binding
HIX64_19195	COG0067	glutamate synthase
HIX64_19195	COG0070	glutamate synthase
HIX64_19195	COG0069	glutamate synthase activity
HIX64_19200	COG0493	'glutamate synthase
HIX64_19205	COG4804	nuclease activity
HIX64_19210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HIX64_19215	COG0402	S-adenosylhomocysteine deaminase activity
HIX64_19220	COG2731	YhcH YjgK YiaL family protein
HIX64_19250	COG2969	positive regulation of protein catabolic process
HIX64_19255	COG0625	glutathione transferase activity
HIX64_19275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HIX64_19280	COG3105	Protein conserved in bacteria
HIX64_19285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIX64_19315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIX64_19320	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HIX64_19325	COG0471	metal ion transport
HIX64_19335	COG2188	Transcriptional regulator
HIX64_19360	COG2732	(Barnase) inhibitor
HIX64_19380	COG0583	DNA-binding transcription factor activity
HIX64_19385	COG0312	modulator of DNA gyrase
HIX64_19390	COG3164	Protein of unknown function
HIX64_19405	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HIX64_19410	COG1792	Involved in formation and maintenance of cell shape
HIX64_19415	COG1077	Cell shape determining protein MreB Mrl
HIX64_19420	COG2200	EAL domain
HIX64_19420	COG2199	diguanylate cyclase activity
HIX64_19425	COG0604	alcohol dehydrogenase
HIX64_19440	COG0511	ligase activity, forming carbon-carbon bonds
HIX64_19445	COG0439	Biotin carboxylase
HIX64_19450	COG3924	membrane
HIX64_19455	COG4145	pantothenate transmembrane transporter activity
HIX64_19475	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HIX64_19490	COG1309	transcriptional regulator
HIX64_19495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIX64_19500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIX64_19545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HIX64_19565	COG0551	DNA topoisomerase type I activity
HIX64_19575	COG0758	DNA mediated transformation
HIX64_19605	COG3036	rescue of stalled ribosome
HIX64_19610	COG0789	Transcriptional regulator
HIX64_19650	COG0201	protein transport
HIX64_19730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HIX64_19755	COG0051	transcription antitermination factor activity, RNA binding
HIX64_19810	COG2964	Protein conserved in bacteria
HIX64_19815	COG0545	Peptidyl-prolyl cis-trans isomerase
HIX64_19825	COG1047	Peptidyl-prolyl cis-trans
HIX64_19830	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HIX64_19845	COG0488	(ABC) transporter
HIX64_19860	COG0429	hydrolase of the alpha beta-hydrolase fold
HIX64_19870	COG3954	Phosphoribulokinase
HIX64_19875	COG1765	OsmC-like protein
HIX64_19885	COG1289	transmembrane transporter activity
HIX64_19920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIX64_19960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIX64_19965	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HIX64_19970	COG3266	domain, Protein
HIX64_19985	COG4796	Type ii and iii secretion system protein
HIX64_20000	COG3166	PFAM Fimbrial assembly family protein
HIX64_20005	COG4972	Pilus assembly protein
HIX64_20010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HIX64_20015	COG0494	nUDIX hydrolase
HIX64_20025	COG1011	Hydrolase
HIX64_20030	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HIX64_20040	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HIX64_20060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIX64_20065	COG2183	response to ionizing radiation
HIX64_20070	COG1918	ferrous iron import across plasma membrane
HIX64_20085	COG5464	transposase or invertase
HIX64_20105	COG2610	gluconate transmembrane transporter activity
HIX64_20110	COG1640	4-alpha-glucanotransferase
HIX64_20115	COG0058	SHG alpha-glucan phosphorylase activity
HIX64_20125	COG1349	DNA-binding transcription factor activity
HIX64_20140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HIX64_20155	COG0371	Dehydrogenase
HIX64_20165	COG0129	dihydroxy-acid dehydratase activity
HIX64_20170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIX64_20175	COG1414	Transcriptional regulator
HIX64_20180	COG0058	SHG alpha-glucan phosphorylase activity
HIX64_20200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HIX64_20215	COG2610	gluconate transmembrane transporter activity
HIX64_20220	COG3265	gluconokinase activity
HIX64_20225	COG1609	Transcriptional regulator
HIX64_20230	COG1741	Belongs to the pirin family
HIX64_20235	COG0673	inositol 2-dehydrogenase activity
HIX64_20240	COG1247	-acetyltransferase
HIX64_20245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_20260	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HIX64_20265	COG0405	Gamma-glutamyltransferase
HIX64_20275	COG0584	glycerophosphoryl diester phosphodiesterase
HIX64_20355	COG2177	Part of the ABC transporter FtsEX involved in
HIX64_20360	COG2884	Cell division ATP-binding protein ftsE
HIX64_20365	COG0552	protein localization to endoplasmic reticulum
HIX64_20370	COG0742	ribosomal rna small subunit methyltransferase
HIX64_20375	COG3776	membrane
HIX64_20385	COG3714	YhhN family
HIX64_20405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HIX64_20420	COG0628	permease
HIX64_20440	COG0842	Transport permease protein
HIX64_20445	COG0842	Transport permease protein
HIX64_20445	COG1129	ABC transporter
HIX64_20450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIX64_20455	COG2081	HI0933 family
HIX64_20460	COG0306	phosphate transporter
HIX64_20490	COG0671	phosphoesterase, PA-phosphatase related
HIX64_20495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HIX64_20500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIX64_20510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HIX64_20515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_20520	COG2222	sugar isomerase
HIX64_20525	COG2188	Transcriptional regulator
HIX64_20545	COG2197	response regulator
HIX64_20555	COG0583	DNA-binding transcription factor activity
HIX64_20560	COG1295	ribonuclease BN
HIX64_20565	COG0477	Major facilitator Superfamily
HIX64_20570	COG2982	Protein involved in outer membrane biogenesis
HIX64_20575	COG2200	EAL domain
HIX64_20580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_20595	COG2199	diguanylate cyclase activity
HIX64_20595	COG2200	EAL domain
HIX64_20610	COG1215	transferase activity, transferring glycosyl groups
HIX64_20660	COG0814	amino acid
HIX64_20665	COG4608	Belongs to the ABC transporter superfamily
HIX64_20670	COG0444	Belongs to the ABC transporter superfamily
HIX64_20675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIX64_20680	COG0601	transmembrane transport
HIX64_20685	COG0747	negative chemotaxis
HIX64_20700	COG1609	Transcriptional regulator
HIX64_20755	COG5571	outer membrane autotransporter
HIX64_20760	COG2818	Glycosylase
HIX64_20765	COG0456	acetyltransferase
HIX64_20770	COG0243	molybdopterin cofactor binding
HIX64_20775	COG2885	chlorophyll binding
HIX64_20790	COG2944	sequence-specific DNA binding
HIX64_20795	COG1278	Cold shock
HIX64_20815	COG1335	isochorismatase
HIX64_20820	COG2814	Major facilitator Superfamily
HIX64_20830	COG2801	Transposase and inactivated derivatives
HIX64_20850	COG3274	enterobacterial common antigen metabolic process
HIX64_20855	COG4682	membrane
HIX64_20860	COG1070	Carbohydrate kinase
HIX64_20870	COG1609	Transcriptional regulator
HIX64_20870	COG2207	Transcriptional regulator
HIX64_20875	COG2992	FlgJ-related protein
HIX64_20880	COG0366	Alpha amylase catalytic
HIX64_20885	COG3977	Valine--pyruvate aminotransferase
HIX64_20890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIX64_20895	COG1414	Transcriptional regulator
HIX64_20905	COG2731	YhcH YjgK YiaL family protein
HIX64_20915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HIX64_20920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HIX64_20925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HIX64_20930	COG1070	Carbohydrate kinase
HIX64_20935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HIX64_20940	COG3623	hexulose-6-phosphate isomerase
HIX64_20945	COG0235	Class ii aldolase
HIX64_20960	COG1012	belongs to the aldehyde dehydrogenase family
HIX64_20965	COG1940	carbohydrate kinase activity
HIX64_20970	COG3276	selenocysteine insertion sequence binding
HIX64_20980	COG0625	glutathione transferase activity
HIX64_20985	COG1566	PFAM secretion protein HlyD family protein
HIX64_20995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_20995	COG2213	PTS system mannitol-specific
HIX64_21005	COG3722	fumarate hydratase activity
HIX64_21035	COG2186	Transcriptional regulator
HIX64_21045	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HIX64_21050	COG1609	Transcriptional regulator
HIX64_21060	COG2271	Major facilitator Superfamily
HIX64_21080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HIX64_21085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HIX64_21095	COG4942	peptidase
HIX64_21100	COG2861	carbohydrate metabolic process
HIX64_21105	COG1216	Glycosyl transferase, family 2
HIX64_21180	COG0438	transferase activity, transferring glycosyl groups
HIX64_21185	COG0859	PFAM glycosyl transferase family 9
HIX64_21190	COG1519	Transferase
HIX64_21220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIX64_21245	COG1561	YicC-like family, N-terminal region
HIX64_21250	COG0583	DNA-binding transcription factor activity
HIX64_21260	COG2860	membrane
HIX64_21280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIX64_21285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIX64_21290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIX64_21295	COG0786	glutamate:sodium symporter activity
HIX64_21300	COG2233	PERMEase
HIX64_21305	COG2982	Protein involved in outer membrane biogenesis
HIX64_21310	COG1501	Belongs to the glycosyl hydrolase 31 family
HIX64_21315	COG2211	Major facilitator Superfamily
HIX64_21330	COG2771	luxR family
HIX64_21345	COG3710	Transcriptional regulator
HIX64_21360	COG1335	isochorismatase
HIX64_21390	COG5464	transposase or invertase
HIX64_21405	COG3716	PTS system mannose fructose sorbose family IID component
HIX64_21410	COG3715	PTS system
HIX64_21415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HIX64_21415	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_21435	COG2723	6-phospho-beta-galactosidase activity
HIX64_21470	COG3775	system Galactitol-specific IIC component
HIX64_21475	COG3414	Phosphotransferase system galactitol-specific IIB component
HIX64_21480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIX64_21480	COG3711	transcriptional antiterminator
HIX64_21485	COG2188	Transcriptional regulator
HIX64_21520	COG0738	Major facilitator superfamily
HIX64_21530	COG1349	DNA-binding transcription factor activity
HIX64_21535	COG0440	acetolactate synthase activity
HIX64_21540	COG0028	Belongs to the TPP enzyme family
HIX64_21565	COG2814	Major facilitator Superfamily
HIX64_21575	COG0583	DNA-binding transcription factor activity
HIX64_21580	COG2610	gluconate transmembrane transporter activity
HIX64_21590	COG0641	radical SAM
HIX64_21600	COG2149	membrane
HIX64_21620	COG5645	(Lipo)protein
HIX64_21625	COG0823	Involved in the tonB-independent uptake of proteins
HIX64_21650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HIX64_21655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HIX64_21670	COG1858	cytochrome C peroxidase
HIX64_21685	COG3005	denitrification pathway
HIX64_21690	COG0745	RESPONSE REGULATOR receiver
HIX64_21695	COG1879	ABC-type sugar transport system periplasmic component
HIX64_21700	COG0784	Response regulator, receiver
HIX64_21700	COG2198	Histidine kinase
HIX64_21700	COG2205	protein histidine kinase activity
HIX64_21720	COG0561	phosphatase activity
HIX64_21725	COG2271	Major facilitator Superfamily
HIX64_21730	COG4948	Mandelate Racemase Muconate Lactonizing
HIX64_21795	COG2091	lysine biosynthetic process via aminoadipic acid
HIX64_21800	COG0431	NADPH-dependent FMN reductase
HIX64_21805	COG2252	PERMEase
HIX64_21810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HIX64_21815	COG0704	Plays a role in the regulation of phosphate uptake
HIX64_21825	COG0581	inorganic phosphate transmembrane transporter activity
HIX64_21830	COG0573	inorganic phosphate transmembrane transporter activity
HIX64_21835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HIX64_21840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIX64_21840	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HIX64_21840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIX64_21845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HIX64_21850	COG4533	DNA binding
HIX64_21910	COG3312	ion transport
HIX64_21925	COG0716	FMN binding
HIX64_21930	COG1522	sequence-specific DNA binding
HIX64_21965	COG1172	Belongs to the binding-protein-dependent transport system permease family
HIX64_21975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_21980	COG1609	Transcriptional regulator
HIX64_21985	COG0477	Major facilitator Superfamily
HIX64_21990	COG2186	Transcriptional regulator
HIX64_22055	COG3978	acetolactate synthase activity
HIX64_22120	COG3118	belongs to the thioredoxin family
HIX64_22135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HIX64_22150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HIX64_22155	COG1088	dTDP-glucose 4,6-dehydratase activity
HIX64_22160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HIX64_22165	COG0456	acetyltransferase
HIX64_22170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HIX64_22175	COG2244	polysaccharide biosynthetic process
HIX64_22220	COG3071	HemY protein
HIX64_22225	COG2959	enzyme of heme biosynthesis
HIX64_22285	COG1011	Hydrolase
HIX64_22330	COG1280	lysine exporter protein (LysE YggA)
HIX64_22335	COG1280	lysine exporter protein (LysE YggA)
HIX64_22340	COG2267	carboxylic ester hydrolase activity
HIX64_22345	COG0561	phosphatase activity
HIX64_22365	COG0641	radical SAM
HIX64_22410	COG0805	protein transport
HIX64_22425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HIX64_22455	COG1739	Uncharacterized protein family UPF0029
HIX64_22495	COG1763	Mo-molybdopterin cofactor biosynthetic process
HIX64_22505	COG3084	Protein conserved in bacteria
HIX64_22520	COG0204	Acyl-transferase
HIX64_22575	COG0561	phosphatase activity
HIX64_22620	COG1501	Belongs to the glycosyl hydrolase 31 family
HIX64_22625	COG2017	converts alpha-aldose to the beta-anomer
HIX64_22635	COG3684	Belongs to the aldolase LacD family
HIX64_22645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIX64_22650	COG1349	DNA-binding transcription factor activity
HIX64_22655	COG1011	Hydrolase
HIX64_22670	COG0456	acetyltransferase
HIX64_22675	COG5499	transcription regulator containing HTH domain
HIX64_22680	COG4680	protein conserved in bacteria
HIX64_22690	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HIX64_22705	COG2864	formate dehydrogenase
HIX64_22710	COG0437	4 iron, 4 sulfur cluster binding
HIX64_22720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HIX64_22740	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIX64_22755	COG1454	alcohol dehydrogenase
HIX64_22800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HIX64_22810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HIX64_22815	COG2258	MOSC domain
HIX64_22825	COG2205	protein histidine kinase activity
HIX64_22830	COG0745	RESPONSE REGULATOR receiver
HIX64_22835	COG3678	ATP-independent chaperone mediated protein folding
HIX64_22840	COG4974	Belongs to the 'phage' integrase family
HIX64_22890	COG3158	transport of potassium into the cell
HIX64_22915	COG3335	DDE superfamily endonuclease
HIX64_22940	COG1201	RNA secondary structure unwinding
HIX64_23060	COG0675	Transposase, IS605 OrfB family
HIX64_23280	COG0250	Participates in transcription elongation, termination and antitermination
HIX64_23290	COG2200	EAL domain
HIX64_23290	COG2771	luxR family
HIX64_23350	COG2204	response regulator
HIX64_23355	COG0814	amino acid
HIX64_23375	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIX64_23380	COG4771	TonB-dependent receptor
HIX64_23385	COG1021	2,3-dihydroxybenzoate-AMP ligase
HIX64_23405	COG3433	isochorismatase activity
HIX64_23405	COG2226	methyltransferase
HIX64_23405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIX64_23420	COG1132	(ABC) transporter
HIX64_23425	COG2814	Major facilitator Superfamily
HIX64_23460	COG4974	Belongs to the 'phage' integrase family
HIX64_23515	COG0477	Major facilitator Superfamily
HIX64_23520	COG3111	PFAM Bacterial OB fold (BOF) protein
HIX64_23525	COG3335	DDE superfamily endonuclease
HIX64_23535	COG0531	amino acid
HIX64_23540	COG1275	C4-dicarboxylate transporter malic acid transport protein
HIX64_23545	COG1982	Orn Lys Arg decarboxylase major
HIX64_23630	COG5001	Diguanylate cyclase
HIX64_23630	COG3300	MHYT domain
HIX64_23685	COG0697	spore germination
HIX64_23755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HIX64_23770	COG0741	lytic transglycosylase activity
HIX64_23820	COG2805	Type II/IV secretion system protein
HIX64_24035	COG1475	DNA binding
HIX64_24195	COG1121	(ABC) transporter
HIX64_24215	COG0431	NADPH-dependent FMN reductase
HIX64_24400	COG2003	Belongs to the UPF0758 family