locus-tag class description E8N14_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E8N14_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E8N14_00030 ENOG4105CXK mandelate racemase muconate lactonizing E8N14_00035 ENOG4105DJB Major Facilitator Superfamily E8N14_00040 ENOG410667J hydrolase E8N14_00045 ENOG4105EMF GntR family transcriptional regulator E8N14_00050 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 E8N14_00055 ENOG4108RTU Aldolase E8N14_00065 ENOG4105DJB Major Facilitator Superfamily E8N14_00070 ENOG4105BZU Histidine kinase E8N14_00075 ENOG4108SV3 Tmao reductase system periplasmic protein tort E8N14_00080 ENOG4106WF9 DNA-binding transcriptional regulator TorR E8N14_00085 ENOG4105CUW cytochrome C-TYPE protein E8N14_00090 ENOG4108EM1 reductase E8N14_00100 ENOG4105CA0 peroxidase E8N14_00110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E8N14_00115 ENOG41060IM Heme exporter protein E8N14_00120 ENOG4105X3C heme exporter protein E8N14_00125 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) E8N14_00130 ENOG4105DA4 cytochrome c-type biogenesis protein E8N14_00135 ENOG4107QX9 Thiol disulfide interChange protein E8N14_00140 ENOG4105KWW Biogenesis protein E8N14_00145 ENOG4105D99 atp gtp-binding protein E8N14_00150 ENOG4105R2A (LipO)protein E8N14_00170 ENOG4105VG5 Membrane E8N14_00175 ENOG4105JP4 Inner membrane protein yidG E8N14_00180 ENOG4105J13 transcriptional regulator E8N14_00195 ENOG4105W8I Transcriptional regulator E8N14_00205 ENOG4105E5M Multidrug resistance protein D E8N14_00230 ENOG4105C7K acetolactate synthase E8N14_00235 ENOG4105M71 acetolactate synthase 1 regulatory subunit E8N14_00240 ENOG4107FB0 transcriptional regulator DeoR family E8N14_00250 ENOG4105EDR glucose galactose transporter E8N14_00260 ENOG4108KX4 response regulator E8N14_00265 ENOG4105BZU Histidine kinase E8N14_00270 ENOG4105CXY transporter E8N14_00275 ENOG4105CXY transporter E8N14_00280 ENOG4108SAJ Protein of unknown function (DUF1198) E8N14_00295 ENOG41090UW PTS System E8N14_00300 ENOG4105DT3 PTS system, galactitol-specific IIc component E8N14_00310 ENOG4105D2N Aldolase E8N14_00335 ENOG4105CS2 ec 3.2.1.21 E8N14_00355 ENOG4105DAS pts system E8N14_00360 ENOG4105ETZ PTS System E8N14_00365 ENOG4105F3R pts system mannose fructose sorbose family iid E8N14_00380 ENOG4105DNE Transposase E8N14_00385 ENOG4108UZ3 Transporter E8N14_00395 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E8N14_00410 ENOG4105CHJ isochorismatase hydrolase E8N14_00420 ENOG4108TC1 Transcriptional regulator E8N14_00425 ENOG4105FV3 E8N14_00435 ENOG4105ISV protein with bipartite regulator domain E8N14_00455 ENOG4105CT4 transporter E8N14_00460 ENOG4105CJQ hydrolase, family 31 E8N14_00465 ENOG4105JV1 AsmA family E8N14_00470 ENOG4105C2W permease E8N14_00475 ENOG4105D6U Sodium Glutamate Symporter E8N14_00480 ENOG4105CB5 ATP-dependent DNA helicase recG E8N14_00485 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase E8N14_00490 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E8N14_00510 ENOG4105EN6 Membrane E8N14_00525 ENOG4105DSJ YicC domain protein E8N14_00530 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) E8N14_00550 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E8N14_00580 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E8N14_00585 ENOG4105DKP glycosyl transferase, family 9 E8N14_00590 ENOG4107RJ7 Glycosyl transferase (Group 1 E8N14_00595 ENOG4107543 (lipo)polysaccharide E8N14_00605 ENOG4107XU6 Glycosyl transferase (Group 1 E8N14_00610 ENOG4106AH0 Glycosyl Transferase E8N14_00615 ENOG4105X1N Glycosyl transferase family 8 E8N14_00620 ENOG4108PDR lipopolysaccharide core biosynthesis protein E8N14_00625 ENOG4108QD8 lipopolysaccharide core biosynthesis protein E8N14_00630 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase E8N14_00635 ENOG4108FRV O-antigen ligase E8N14_00640 ENOG4105D16 lipopolysaccharide heptosyltransferase i E8N14_00645 ENOG4105XA0 heptosyltransferase ii E8N14_00655 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E8N14_00665 ENOG4105K64 Glycosyl transferase, family 2 E8N14_00670 ENOG4105PXI polysaccharide deacetylase E8N14_00675 ENOG41063SB peptidase E8N14_00685 ENOG4107YZP Rhodanese domain protein E8N14_00690 ENOG4105VW4 glutaredoxin 3 E8N14_00695 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) E8N14_00700 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase E8N14_00705 ENOG4105D7W serine acetyltransferase E8N14_00710 ENOG4105DJB Major Facilitator Superfamily E8N14_00715 ENOG4105DIA mandelate racemase muconate lactonizing E8N14_00720 ENOG4105ETE Transcriptional regulator (LacI family E8N14_00725 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E8N14_00735 ENOG41073TP transcriptional regulator E8N14_00740 ENOG4105DAA L-lactate E8N14_00745 ENOG4105EUR Domain-Containing protein E8N14_00750 ENOG4108WY4 inner membrane lipoprotein E8N14_00755 ENOG4108YYI Protein of unknown function (DUF2810) E8N14_00765 ENOG4105E61 Mannitol repressor protein E8N14_00775 ENOG4105CTS PTS system mannitol-specific E8N14_00780 ENOG4108U78 Glutathione S-transferase E8N14_00790 ENOG4105EM7 Selenocysteine-specific translation elongation factor E8N14_00795 ENOG41066F8 ROK family E8N14_00800 ENOG4105C26 Dehydrogenase E8N14_00815 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E8N14_00820 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase E8N14_00825 ENOG4105H6Q decarboxylase E8N14_00830 ENOG4105CMG Carbohydrate kinase E8N14_00835 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E8N14_00840 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E8N14_00845 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E8N14_00850 ENOG4108M5W E8N14_00855 ENOG4108R66 Conserved Protein E8N14_00860 ENOG4105DG4 malate L-lactate dehydrogenase E8N14_00865 ENOG4105J4Q Transcriptional regulator E8N14_00870 ENOG4108XIB electron transport protein ysaA E8N14_00875 ENOG4105JKW Valine--pyruvate aminotransferase E8N14_00880 ENOG4107T9C Alpha amylase catalytic region E8N14_00885 ENOG4108UR8 BAX protein E8N14_00890 ENOG4105T16 Transcriptional regulator (AraC family) E8N14_00900 ENOG4105CMG Carbohydrate kinase E8N14_00905 ENOG410688U Inner membrane protein yiaB E8N14_00910 ENOG4105MEV Acyl-transferase E8N14_00920 ENOG4105RGS lipoprotein ysaB E8N14_00945 ENOG4105MVF Transcriptional regulator E8N14_00950 ENOG4106JH6 (LipO)protein E8N14_00960 ENOG4108ZG0 Ompa motb domain protein E8N14_00965 ENOG4107QY8 reductase E8N14_00970 ENOG4105HNP -acetyltransferase E8N14_00975 ENOG4108R3E Dna-3-methyladenine glycosylase i E8N14_00985 ENOG4106EAR Fimbrial protein E8N14_00990 ENOG4108VCD Chaperone E8N14_00995 ENOG4105CW0 outer membrane usher protein E8N14_01000 ENOG4105MHR Fimbrial protein E8N14_01005 ENOG4106UCC Fimbrial protein E8N14_01010 ENOG4105DIJ Phosphoethanolamine transferase E8N14_01025 ENOG4105CQ4 Transcriptional regulator E8N14_01040 ENOG4105DEF Extracellular solute-binding protein, family 5 E8N14_01045 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E8N14_01050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E8N14_01055 ENOG4105C3U ABC transporter E8N14_01060 ENOG4108JQ7 (ABC) transporter E8N14_01065 ENOG4105C44 Serine transporter E8N14_01080 ENOG4105D1V cellulose synthase operon protein YhjU E8N14_01085 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT E8N14_01095 ENOG410661M cytoplasmic protein E8N14_01100 ENOG4105UTS cellulose synthase operon protein YhjQ E8N14_01105 ENOG4107QZ7 Cellulose synthase catalytic subunit E8N14_01110 ENOG4107EEX Cellulose synthase regulator protein E8N14_01115 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) E8N14_01120 ENOG4105EJG cellulose synthase E8N14_01125 ENOG4105BZU Histidine kinase E8N14_01135 ENOG4105CS0 peptidase E8N14_01140 ENOG4107SS6 2-dehydro-3-deoxygluconokinase E8N14_01145 ENOG4105CMB EAL domain-containing protein E8N14_01150 ENOG41066T0 asmA family E8N14_01155 ENOG4105CSH Transporter E8N14_01160 ENOG4107H3J ribonuclease E8N14_01165 ENOG4105CBN LysR family transcriptional regulator E8N14_01170 ENOG4106S2D Transcriptional regulator E8N14_01190 ENOG4105FDP GntR family transcriptional regulator E8N14_01195 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E8N14_01200 ENOG4108KPW sugar kinase E8N14_01205 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E8N14_01215 ENOG4105DC8 reductase E8N14_01220 ENOG4105D6S protein involved in catabolism of external DNA E8N14_01230 ENOG410657R replicase EC 2.7 E8N14_01235 ENOG4105DGW oligopeptidase A E8N14_01240 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) E8N14_01245 ENOG4105DUX Transporter E8N14_01250 ENOG4108M6U Universal stress protein A E8N14_01260 ENOG4105CJ3 phosphate transporter E8N14_01265 ENOG4105CBX hi0933 family E8N14_01270 ENOG4105D0S secretion protein (HlyD E8N14_01275 ENOG4105CJ1 ABC, transporter E8N14_01280 ENOG4105CMI transporter E8N14_01290 ENOG4107YAK holo-(acyl carrier protein) synthase 2 E8N14_01295 ENOG4105DSF transport protein E8N14_01305 ENOG4108W1V Lipoprotein E8N14_01310 ENOG4105EX9 Membrane E8N14_01320 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_01330 ENOG4107FS9 Membrane E8N14_01340 ENOG4105MG3 Membrane E8N14_01345 ENOG4106H78 methyltransferase E8N14_01350 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E8N14_01355 ENOG4105CAK Cell division ATP-binding protein ftsE E8N14_01360 ENOG4105CRP Part of the ABC transporter FtsEX involved in E8N14_01370 ENOG4105CP9 extracellular ligand-binding receptor E8N14_01380 ENOG4105U59 -acetyltransferase E8N14_01385 ENOG4105CP9 extracellular ligand-binding receptor E8N14_01390 ENOG4105C32 Amino acid ABC transporter (Permease) E8N14_01395 ENOG4105CF8 branched-chain amino acid ABC transporter, permease E8N14_01400 ENOG4105C0Z ABC transporter E8N14_01405 ENOG4108IV0 ABC, transporter E8N14_01410 ENOG41060M8 Pfam:PhdYeFM E8N14_01420 ENOG4105BZ7 extracellular solute-binding protein family 1 E8N14_01425 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component E8N14_01435 ENOG4108IJ9 (ABC) transporter E8N14_01440 ENOG4107T6V glycerophosphoryl diester phosphodiesterase E8N14_01445 ENOG4105WC8 Conserved Protein E8N14_01450 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E8N14_01455 ENOG41080QX K07048 phosphotriesterase-related protein E8N14_01470 ENOG4108RVA ribokinase E8N14_01475 ENOG4105WCN acetyltransferase E8N14_01480 ENOG4105D9R oxidoreductase E8N14_01485 ENOG4105C2I pirin domain protein E8N14_01490 ENOG4105DIQ Transcriptional regulator E8N14_01495 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E8N14_01500 ENOG4105C6Z Gluconate E8N14_01510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E8N14_01515 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E8N14_01535 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E8N14_01540 ENOG4107HP6 Transcriptional regulator E8N14_01545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E8N14_01550 ENOG4105C01 Dihydroxy-acid dehydratase E8N14_01560 ENOG4105DCT glycerol dehydrogenase E8N14_01575 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E8N14_01590 ENOG4105E98 transcriptional regulator DeoR family E8N14_01600 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) E8N14_01605 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) E8N14_01610 ENOG4105C6Z Gluconate E8N14_01620 ENOG4105MJ2 Competence protein E8N14_01630 ENOG4105DNE Transposase E8N14_01645 ENOG4105XFK Ferrous iron transport protein A E8N14_01650 ENOG4105BZM domain protein E8N14_01655 ENOG4108RRZ Transcription elongation factor GreB E8N14_01665 ENOG4105E0F Histidine kinase E8N14_01675 ENOG4108MAJ Membrane E8N14_01685 ENOG4105VEJ Heat shock protein E8N14_01690 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E8N14_01700 ENOG4107RK2 ADP-ribose diphosphatase NudE E8N14_01705 ENOG4108JQC penicillin-binding protein 1A E8N14_01710 ENOG4108U1Q Pilus assembly protein E8N14_01715 ENOG41065NF Fimbrial assembly family protein E8N14_01720 ENOG4105XPX DNA utilization protein HofO E8N14_01725 ENOG4105ITY Required for the use of extracellular DNA as a nutrient E8N14_01730 ENOG4105E4G Type IV pilus E8N14_01745 ENOG4105EGB membrane protein DamX E8N14_01750 ENOG4105DFE Dna adenine methylase E8N14_01755 ENOG4105DJV ribulose-phosphate 3-epimerase E8N14_01765 ENOG4105C31 Tryptophanyl-tRNA synthetase E8N14_01770 ENOG4105VYH E8N14_01775 ENOG4107EF2 surface-exposed virulence protein E8N14_01785 ENOG4107V9H nitrite transporter E8N14_01790 ENOG4105WZK nitrite reductase NADPH small subunit E8N14_01795 ENOG4107QZF nitrite reductase NADPH large subunit E8N14_01805 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E8N14_01810 ENOG4106195 uncharacterized protein yhfG E8N14_01815 ENOG4105MZU cell filamentation protein E8N14_01820 ENOG4105DDQ anthranilate synthase E8N14_01825 ENOG4105C8Y Acetylornithine aminotransferase E8N14_01830 ENOG410613R integral membrane protein, YccS YhfK family E8N14_01835 ENOG4107RYR Transcriptional regulator, Crp Fnr family E8N14_01840 ENOG4108UKZ OsmC family E8N14_01845 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) E8N14_01855 ENOG4105DNZ Alpha Beta Hydrolase E8N14_01860 ENOG4105N0V mono-oxygenase ydhR E8N14_01865 ENOG4108K70 Transcriptional regulator E8N14_01870 ENOG4105C5H ABC transporter E8N14_01885 ENOG4105VKU nucleicacid-binding protein E8N14_01890 ENOG4108YZY peptidylprolyl cis-trans isomerase E8N14_01895 ENOG4105VRX Protein slyX homolog E8N14_01900 ENOG4108V1T peptidylprolyl cis-trans isomerase E8N14_01905 ENOG4105WWK YheO domain protein E8N14_01920 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) E8N14_01930 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) E8N14_01940 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E8N14_01945 ENOG4105W53 bacterioferritin-associated ferredoxin E8N14_01950 ENOG4108UQY Iron-storage protein E8N14_01955 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E8N14_01985 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) E8N14_02005 ENOG41083MP 50s ribosomal protein l29 E8N14_02010 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal E8N14_02020 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) E8N14_02045 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) E8N14_02055 ENOG4105VPB 50S ribosomal protein L30 E8N14_02065 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E8N14_02070 ENOG41067V7 50S ribosomal protein L36 E8N14_02085 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) E8N14_02100 ENOG4105VTS DnaJ-like, subfamily C E8N14_02105 ENOG4105W1Y Transcriptional regulator E8N14_02110 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system E8N14_02115 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) E8N14_02120 ENOG4105C1A potassium transporter peripheral membrane E8N14_02140 ENOG4105C79 DNA protecting protein DprA E8N14_02150 ENOG4108WI1 Dna topoisomerase E8N14_02165 ENOG4105SG3 Protein of unknown function (DUF1488) E8N14_02170 ENOG4108Z0R Transferase E8N14_02205 ENOG4105XCM membrane LIPOPROTEIN E8N14_02210 ENOG4105BZS acriflavin resistance protein E8N14_02215 ENOG4105C1P efflux transporter, rnd family, mfp subunit E8N14_02220 ENOG4108XG4 DNA-binding transcriptional regulator E8N14_02225 ENOG4105BZU Histidine kinase E8N14_02230 ENOG41061ME transport protein E8N14_02235 ENOG4105CEC DNA methylase N-4 N-6 E8N14_02245 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E8N14_02255 ENOG4108IA2 Sodium pantothenate symporter E8N14_02260 ENOG4105RG0 Membrane E8N14_02265 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E8N14_02270 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E8N14_02285 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family E8N14_02290 ENOG41062P1 Diguanylate cyclase phosphodiesterase E8N14_02300 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E8N14_02305 ENOG4105VQ7 Rod shape-determining protein MreD E8N14_02315 ENOG4105C03 ribonuclease E8N14_02320 ENOG4105QD6 exported protein E8N14_02325 ENOG4105D1U peptidase U62 modulator of DNA gyrase E8N14_02330 ENOG4105CR8 Transcriptional regulator E8N14_02335 ENOG4105ZQC membrane protein AaeX E8N14_02350 ENOG4105UNR (Barnase) inhibitor E8N14_02355 ENOG4105RID UPF0379 protein yhcN E8N14_02360 ENOG4105RID UPF0379 protein yhcN E8N14_02385 ENOG4105C8P )-transporter E8N14_02390 ENOG4106DSS Tartrate dehydratase subunit alpha E8N14_02395 ENOG4107GFK fumarate E8N14_02405 ENOG4107QSA Oxaloacetate decarboxylase E8N14_02410 ENOG4105D9Q decarboxylase (Beta subunit) E8N14_02425 ENOG4105C0H protease E8N14_02430 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III E8N14_02435 ENOG4105D6Z AFG1 family ATPase E8N14_02460 ENOG4107MKT Stringent starvation protein a E8N14_02465 ENOG4105KB2 stringent starvation protein b E8N14_02485 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E8N14_02495 ENOG4108R66 Conserved Protein E8N14_02500 ENOG4105DZC cytosine deaminase E8N14_02505 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin E8N14_02515 ENOG4105BZ8 glutamate synthase E8N14_02520 ENOG4105CBC glutamate synthase E8N14_02525 ENOG4105N5T Radical SAM Protein E8N14_02530 ENOG4105BZU Histidine kinase E8N14_02535 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain E8N14_02545 ENOG4108NIH transferase activity, transferring phosphorus-containing groups E8N14_02550 ENOG41080Z8 PHOSPHOCARRIER protein E8N14_02560 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN E8N14_02565 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA E8N14_02570 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E8N14_02575 ENOG4108IUZ ABC transporter E8N14_02580 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E8N14_02585 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) E8N14_02590 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E8N14_02595 ENOG4105C2X Arabinose 5-phosphate isomerase E8N14_02600 ENOG4105FEU K -dependent Na -Ca exchanger E8N14_02605 ENOG4105DHJ ABC, transporter E8N14_02610 ENOG4105CY3 ABC transporter, permease E8N14_02615 ENOG4107PE3 Mammalian cell entry related domain protein E8N14_02620 ENOG4105E3I toluene tolerance E8N14_02625 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane E8N14_02630 ENOG4105VFK BolA family E8N14_02640 ENOG4105HVQ Regulatory factor of maltose metabolism E8N14_02645 ENOG4105EAH synthase E8N14_02655 ENOG4105K46 50S ribosomal protein l27 E8N14_02660 ENOG4105QYV Membrane E8N14_02670 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase E8N14_02675 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) E8N14_02680 ENOG4105HBR Rna-binding protein E8N14_02690 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E8N14_02695 ENOG4105EEI dihydropteroate synthase E8N14_02705 ENOG4105NTZ Preprotein translocase subunit SecG E8N14_02730 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) E8N14_02735 ENOG4105CHV Transcription elongation factor NusA E8N14_02775 ENOG4105C1J atp-dependent rna helicase E8N14_02780 ENOG4105CIC tryptophan-specific transport protein E8N14_02785 ENOG4105DEN Luciferase family E8N14_02805 ENOG4108YYD acetyltransferase E8N14_02820 ENOG4107R7Y intracellular protease Pfpi family E8N14_02825 ENOG4105K4T epimerase E8N14_02830 ENOG4105W4M Transport-associated protein E8N14_02845 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) E8N14_02850 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E8N14_02860 ENOG4107WTH Galactitol-1-phosphate dehydrogenase E8N14_02865 ENOG4105DT3 PTS system, galactitol-specific IIc component E8N14_02870 ENOG41090UW PTS System E8N14_02875 ENOG41082GB PTS system galactitol-specific transporter subunit IIA E8N14_02890 ENOG4105CTX dehydratase E8N14_02900 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E8N14_02905 ENOG4105BZW Glycerate kinase E8N14_02915 ENOG410811B TRANSCRIPTIONal E8N14_02920 ENOG4105C7B Threonine dehydratase E8N14_02935 ENOG4105C6N Formate acetyltransferase E8N14_02940 ENOG4105EJQ L-serine dehydratase E8N14_02945 ENOG4105C44 Serine transporter E8N14_02955 ENOG4106D80 Uncharacterized protein YhaL E8N14_02960 ENOG4108CNN domain protein E8N14_02965 ENOG4105CWB LysR family transcriptional Regulator E8N14_02970 ENOG4105KAF membrAne E8N14_02975 ENOG4105CHF Glutathione S-transferase E8N14_02980 ENOG4108VBZ doxx family E8N14_02985 ENOG4105YJD E8N14_02990 ENOG41090KG Inner membrane protein YqjE E8N14_02995 ENOG4105NE1 Conserved Protein E8N14_03000 ENOG4105WAY exported protein E8N14_03010 ENOG4106W5V Membrane E8N14_03020 ENOG4105DU1 integral membrane protein, terc E8N14_03025 ENOG4105EE0 oxidoreductase E8N14_03030 ENOG4108UB4 uncharacterized protein ygjQ E8N14_03035 ENOG4108VKG metal-dependent hydrolase E8N14_03045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E8N14_03055 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor E8N14_03060 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_03065 ENOG4105NTW Transcriptional regulator E8N14_03070 ENOG4105Q26 Siderophore-interacting protein E8N14_03080 ENOG4108VCA G U mismatch-specific DNA glycosylase E8N14_03085 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E8N14_03090 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E8N14_03115 ENOG4107ZVW dihydroneopterin aldolase E8N14_03130 ENOG4106MWK domain protein E8N14_03135 ENOG4105I7R Adenylate cyclase E8N14_03155 ENOG4107S78 Band 7 protein E8N14_03160 ENOG4105PV3 Inner membrane protein yqiJ E8N14_03170 ENOG4105W0Z cytoplasmic protein E8N14_03180 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) E8N14_03190 ENOG4108MR7 Arylsulfotransferase E8N14_03200 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E8N14_03205 ENOG4106032 Glutathionylspermidine synthase E8N14_03210 ENOG4105F1G UPF0441 protein E8N14_03220 ENOG41087AY ADP-Ribose pyrophosphatase E8N14_03225 ENOG4108SX3 cytoplasmic protein E8N14_03230 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E8N14_03235 ENOG4105IPS esterase E8N14_03240 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E8N14_03245 ENOG4105VRH Antibiotic biosynthesis monooxygenase E8N14_03250 ENOG4105NF4 modulator of drug activity E8N14_03255 ENOG4105DHQ Histidine kinase E8N14_03260 ENOG4105XJC Two component transcriptional regulator (Winged helix family E8N14_03265 ENOG4105H4F exported protein E8N14_03270 ENOG4105F4I Transcriptional regulator E8N14_03275 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E8N14_03280 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase E8N14_03285 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) E8N14_03290 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E8N14_03300 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E8N14_03305 ENOG4105CCT upf0313 protein E8N14_03320 ENOG4107QPK )-transporter E8N14_03325 ENOG4105CV8 reductase E8N14_03330 ENOG4108I6A alcohol dehydrogenase E8N14_03335 ENOG4105CF7 AraC family transcriptional regulator E8N14_03340 ENOG4108K81 inner membrane protein YghB E8N14_03345 ENOG4105C28 cystathionine E8N14_03350 ENOG4105CWK Biopolymer transport protein, ExbB E8N14_03355 ENOG4108ZZF transport protein (ExbD) E8N14_03360 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E8N14_03385 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_03390 ENOG410900S Protein of unknown function (DUF2623) E8N14_03395 ENOG4105E3S small subunit E8N14_03400 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E8N14_03405 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit E8N14_03410 ENOG4105DPX Hydrogenase, large subunit E8N14_03415 ENOG4108USZ hydrogenase E8N14_03420 ENOG4108WGS hydrogenase 2-specific chaperone E8N14_03425 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E8N14_03430 ENOG41082MF Hydrogenase assembly chaperone hypC hupF E8N14_03435 ENOG4105S10 periplasmic binding protein E8N14_03440 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein E8N14_03445 ENOG4105CYM Glutathione S-transferase E8N14_03450 ENOG4106032 Glutathionylspermidine synthase E8N14_03465 ENOG4105DEI Mannitol dehydrogenase E8N14_03475 ENOG4105DPW Major facilitator superfamily MFS_1 E8N14_03500 ENOG4105C26 Dehydrogenase E8N14_03505 ENOG4105CJP fad dependent oxidoreductase E8N14_03515 ENOG4105CUB amino acid E8N14_03525 ENOG4108UAJ Transcriptional regulator E8N14_03535 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E8N14_03545 ENOG4105CI0 Citrate lyase E8N14_03550 ENOG4105DJG MaoC domain protein dehydratase E8N14_03555 ENOG4105CYC Transferase E8N14_03560 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase E8N14_03570 ENOG4108UQV Membrane E8N14_03575 ENOG4105CXN decarboxylase E8N14_03580 ENOG4105EAA nucleoside E8N14_03590 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) E8N14_03595 ENOG4105CEN a g-specific adenine glycosylase E8N14_03605 ENOG41090ED Protein with unknown function (DUF469) E8N14_03610 ENOG4105K33 Periplasmic Protein E8N14_03615 ENOG4105HDK L-asparaginase E8N14_03620 ENOG4106MH3 alpha helix chain E8N14_03625 ENOG4105CSA Coproporphyrinogen iii oxidase E8N14_03640 ENOG4108VIA integral membrane protein E8N14_03645 ENOG4105DFA alanine racemase domain protein E8N14_03650 ENOG4105CZX twitching motility protein E8N14_03670 ENOG4105D7Z glutathione synthase E8N14_03675 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E8N14_03680 ENOG4105RWS endonuclease I E8N14_03690 ENOG4107QNK )-transporter E8N14_03710 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) E8N14_03720 ENOG4107YCY Transcriptional regulator E8N14_03730 ENOG4105DEI Mannitol dehydrogenase E8N14_03735 ENOG4105CPQ Dehydrogenase E8N14_03740 ENOG4105DG4 malate L-lactate dehydrogenase E8N14_03745 ENOG4108R66 Conserved Protein E8N14_03750 ENOG4108MXF Alpha Beta Hydrolase E8N14_03760 ENOG4108K0D peptidase, M48 E8N14_03765 ENOG4105CV1 Transketolase (EC 2.2.1.1) E8N14_03770 ENOG4108JJB ABC transporter E8N14_03775 ENOG4108JJB ABC transporter E8N14_03800 ENOG4105BZA Phosphoglycerate kinase E8N14_03805 ENOG4105D2N Aldolase E8N14_03810 ENOG4105D64 Mechanosensitive ion channel E8N14_03820 ENOG4105MPN Membrane E8N14_03835 ENOG4108JQ1 Dehydrogenase E8N14_03840 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E8N14_03860 ENOG4107RAQ aminopeptidase E8N14_03865 ENOG4105D0A hydroxylase E8N14_03870 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E8N14_03900 ENOG4105CS2 ec 3.2.1.21 E8N14_03910 ENOG4108UT2 hemolysin iii E8N14_03925 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB E8N14_03930 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) E8N14_03935 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E8N14_03940 ENOG4105T95 Thiol disulfide interChange protein E8N14_03945 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E8N14_03965 ENOG4108K5P (LipO)protein E8N14_03985 ENOG4105VGJ Virulence-associated protein E8N14_03990 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A E8N14_04000 ENOG4108T1M outer membrane protein x E8N14_04025 ENOG4106P2F Pfam:Pili_assembly_C E8N14_04055 ENOG4108MHD transport protein E8N14_04065 ENOG4105C5Q Transcriptional regulator E8N14_04070 ENOG4105CHU acetyl-coa acetyltransferase E8N14_04080 ENOG4105CHR reductase E8N14_04085 ENOG4107QNK )-transporter E8N14_04095 ENOG4105RQF LysR family Transcriptional regulator E8N14_04105 ENOG4105DDV Transcriptional regulator (LacI family E8N14_04125 ENOG4105CPC Aldo Keto reductase E8N14_04130 ENOG4105SUV lipoprotein YgdR E8N14_04135 ENOG4105EE5 Membrane protein terC E8N14_04150 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E8N14_04170 ENOG4105IPU prepilin peptidase dependent protein A E8N14_04175 ENOG4105JCS prepilin peptidase dependent protein E8N14_04180 ENOG4105SEN Protein of unknown function (DUF2509) E8N14_04185 ENOG4105RVB Prepilin peptidase dependent protein c E8N14_04190 ENOG4105DSY exodeoxyribonuclease V, gamma E8N14_04195 ENOG4107QXK peptidase E8N14_04200 ENOG4107QKA exodeoxyribonuclease V beta E8N14_04205 ENOG4107QYX exodeoxyribonuclease v alpha E8N14_04210 ENOG4108EKC n-acetylglutamate synthase E8N14_04215 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E8N14_04230 ENOG4105CA3 membrane-bound lytic murein transglycosylase E8N14_04235 ENOG4105CUZ uba thif-type nad fad binding protein E8N14_04240 ENOG4105FR1 rard protein E8N14_04245 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) E8N14_04250 ENOG4105C9B Cysteine desulfurase E8N14_04255 ENOG4105M5B (LipO)protein E8N14_04260 ENOG4105ETT transcriptional Regulator, LysR family E8N14_04265 ENOG4105M08 Membrane E8N14_04275 ENOG4107EDW L-fucose operon activator E8N14_04285 ENOG4105CMG Carbohydrate kinase E8N14_04295 ENOG4105EDR glucose galactose transporter E8N14_04300 ENOG4107W7X Aldolase E8N14_04305 ENOG4105C0A alcohol dehydrogenase E8N14_04315 ENOG4105EJQ L-serine dehydratase E8N14_04320 ENOG4105C44 Serine transporter E8N14_04325 ENOG4105EWT decarboxylase family E8N14_04345 ENOG4105WP7 tRNA pseudouridine synthase C E8N14_04350 ENOG4105DR9 pseudouridine synthase E8N14_04355 ENOG4105QDK Flavodoxin E8N14_04360 ENOG4105DJB Major Facilitator Superfamily E8N14_04365 ENOG4105EQX glucarate dehydratase E8N14_04370 ENOG4105EQX glucarate dehydratase E8N14_04375 ENOG4105BZW Glycerate kinase E8N14_04380 ENOG4105BZU Histidine kinase E8N14_04385 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) E8N14_04390 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E8N14_04410 ENOG4105NEV Fimbrial E8N14_04415 ENOG4108FZ9 Chaperone E8N14_04420 ENOG4106PG1 outer membrane usher protein E8N14_04430 ENOG4105DXN mazG family E8N14_04440 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) E8N14_04445 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E8N14_04450 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E8N14_04455 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase E8N14_04460 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E8N14_04480 ENOG4105DTT CRISPR-associated helicase, cas3 E8N14_04495 ENOG41060M0 Crispr-associated protein, cse4 family E8N14_04500 ENOG4108VWQ crispr-associated protein E8N14_04510 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) E8N14_04515 ENOG4105PWE CRISPR-associated protein cas2 E8N14_04520 ENOG4108MXK alkaline phosphatase isozyme conversion E8N14_04540 ENOG4105N0Z inner membrane protein ygbE E8N14_04575 ENOG4108K5P (LipO)protein E8N14_04585 ENOG4105KZM cytoplasmic protein E8N14_04590 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E8N14_04595 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E8N14_04605 ENOG4105MVE transcriptional regulator E8N14_04615 ENOG4105G63 Type III effector Hrp-dependent E8N14_04625 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E8N14_04630 ENOG4105EXW epimerase dehydratase E8N14_04635 ENOG4105C6Z Gluconate E8N14_04640 ENOG4105JQN Transcriptional regulator E8N14_04645 ENOG4105C0R drug resistance transporter emrb qaca subfamily E8N14_04680 ENOG4105MEW serine threonine protein phosphatase E8N14_04725 ENOG41090HZ type iii secretion E8N14_04735 ENOG4108N8R Invasion protein E8N14_04740 ENOG4108HR8 type iii secretion E8N14_04745 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone E8N14_04750 ENOG4108JIR Flagellum-specific ATP synthase E8N14_04755 ENOG41077MC Secretory protein (Associated with virulence) E8N14_04760 ENOG41078G4 surface presentation of E8N14_04770 ENOG41075IY surface presentation of antigens protein SpaP E8N14_04775 ENOG4105U07 type iii secretion E8N14_04780 ENOG4108TN6 type iii secretion E8N14_04785 ENOG4108M6W surface presentation of antigens protein SpaS E8N14_04795 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE E8N14_04805 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC E8N14_04815 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E8N14_04830 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear E8N14_04840 ENOG4108YAB Invasion protein E8N14_04850 ENOG4108RC9 Type III secretion system protein E8N14_04855 ENOG4105Y7Q type iii secretion E8N14_04860 ENOG4106BTR E8N14_04865 ENOG4108RBT type iii secretion E8N14_04900 ENOG4105CC5 ABC transporter E8N14_04905 ENOG4105CC5 ABC transporter E8N14_04910 ENOG4105DIK (ABC) transporter E8N14_04920 ENOG4105VXR cytoplasmic protein E8N14_04930 ENOG4105C45 hydrogenase expression formation protein (HypE) E8N14_04935 ENOG4105CQS hydrogenase expression formation protein HypD E8N14_04940 ENOG41083WG hydrogenase assembly chaperone E8N14_04945 ENOG4107RSS Hydrogenase accessory protein HypB E8N14_04950 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) E8N14_04955 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA E8N14_04960 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) E8N14_04965 ENOG4107R30 NADH dehydrogenase E8N14_04970 ENOG4107TDF Formate hydrogenlyase subunit 4 E8N14_04975 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E8N14_04980 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit E8N14_04985 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit E8N14_04990 ENOG4105I6X formate hydrogenlyase maturation E8N14_04995 ENOG4108MG9 hydrogenase 3 maturation protease E8N14_05005 ENOG4108RC0 Electron transport protein E8N14_05010 ENOG4105C8H hydrogenase maturation protein Hypf E8N14_05030 ENOG4105C2X Arabinose 5-phosphate isomerase E8N14_05035 ENOG410804X Transcriptional regulator E8N14_05040 ENOG4105J92 DNA-binding transcriptional activator GutM E8N14_05045 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase E8N14_05050 ENOG4105VI0 Pts system, glucitol sorbitol-specific E8N14_05055 ENOG4105DZY Pts system, glucitol sorbitol-specific E8N14_05060 ENOG410787A Pts system, glucitol sorbitol-specific E8N14_05065 ENOG4105CVE Lytic murein transglycosylase E8N14_05075 ENOG4107TH8 cina domain protein E8N14_05095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) E8N14_05100 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) E8N14_05130 ENOG4107VXZ Hydrolase E8N14_05135 ENOG4105W39 Membrane E8N14_05155 ENOG4105C0R drug resistance transporter emrb qaca subfamily E8N14_05160 ENOG4105CW7 secretion protein, HlyD family E8N14_05165 ENOG4105NTK Transcriptional repressor Mpra E8N14_05175 ENOG4105GIJ Glycine betaine E8N14_05180 ENOG4108HQS Glycine betaine E8N14_05185 ENOG4108IJ7 Glycine betaine E8N14_05190 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E8N14_05195 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E8N14_05205 ENOG4105WAZ (Glutaredoxin-like protein) NrdH E8N14_05215 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E8N14_05225 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) E8N14_05230 ENOG4108WMJ Protein of unknown function (DUF2002) E8N14_05235 ENOG4108RNS Exports L-alanine (By similarity) E8N14_05245 ENOG4108X73 DNA- binding protein E8N14_05255 ENOG4108V62 Rhodanese domain protein E8N14_05260 ENOG41080HT Transcriptional regulator, arsr family E8N14_05265 ENOG4105VPI YqaE family transport protein E8N14_05275 ENOG4109066 lysm domain bon superfamily protein E8N14_05280 ENOG4108PVQ transcriptional regulator E8N14_05285 ENOG4105C85 amino acid E8N14_05290 ENOG4108JPW Aminotransferase E8N14_05295 ENOG4105C26 Dehydrogenase E8N14_05300 ENOG4105D5U fad dependent oxidoreductase E8N14_05330 ENOG4105DHQ Histidine kinase E8N14_05350 ENOG4108MJ5 VirK protein E8N14_05355 ENOG4105VRE Pentapeptide repeat protein E8N14_05365 ENOG4107RNH Outer membrane receptor FepA E8N14_05370 ENOG4105NIV Esterase E8N14_05395 ENOG4108C33 Resolvase E8N14_05400 ENOG4105I03 Flagellin E8N14_05430 ENOG4105BZ1 (ABC) transporter E8N14_05450 ENOG4108Z1B Cyclase dehydrase E8N14_05460 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E8N14_05465 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E8N14_05485 ENOG4108JU6 CBS domain protein E8N14_05490 ENOG4106KVJ cytochrome C assembly protein E8N14_05495 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E8N14_05515 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) E8N14_05520 ENOG4108KHX Diguanylate cyclase E8N14_05525 ENOG4108WS1 E8N14_05530 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E8N14_05535 ENOG4105EHE chorismate mutase- prephenate dehydrogenase E8N14_05545 ENOG4105CQC Prephenate dehydratase E8N14_05555 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA E8N14_05565 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E8N14_05570 ENOG4105C34 Pseudouridine synthase E8N14_05575 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E8N14_05580 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E8N14_05610 ENOG4105CSH Transporter E8N14_05615 ENOG4105T42 (LipO)protein E8N14_05620 ENOG4105JIM Phosphatidylserine synthase E8N14_05625 ENOG4105CD5 CoA-binding domain protein E8N14_05630 ENOG4106IUH DTW domain containing protein E8N14_05635 ENOG4105K63 Thioredoxin E8N14_05640 ENOG4105EIB trna rrna methyltransferase E8N14_05650 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) E8N14_05660 ENOG41090KR LysR family transcriptional Regulator E8N14_05665 ENOG4105C1J atp-dependent rna helicase E8N14_05675 ENOG4108IYU L-aspartate oxidase E8N14_05705 ENOG4105WMJ Positive regulator of sigma E, RseC MucC E8N14_05715 ENOG4105C3F Signal peptidase i E8N14_05735 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E8N14_05745 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E8N14_05750 ENOG4105DND Transcriptional regulator E8N14_05760 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E8N14_05765 ENOG4106G6Q Transcriptional regulator E8N14_05780 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB E8N14_05785 ENOG4108Z6B deaminase E8N14_05790 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) E8N14_05805 ENOG4107WP9 Histidine kinase E8N14_05810 ENOG4108SKK alpha helix protein E8N14_05815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E8N14_05825 ENOG4105DUX Transporter E8N14_05830 ENOG4105CXN decarboxylase E8N14_05835 ENOG4105D5Q Arginine ornithine antiporter E8N14_05840 ENOG4108M3R transcriptional activator CadC E8N14_05845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E8N14_05855 ENOG4105D8G Major Facilitator superfamily E8N14_05860 ENOG4108MN2 Stationary phase inducible protein CsiE E8N14_05870 ENOG4105D7X high-affinity nickel-transporter E8N14_05875 ENOG410810Y Sulfite reductase E8N14_05880 ENOG4107SHJ sulfite reductase subunit b E8N14_05885 ENOG4105D5B Sulfite reductase, subunit A E8N14_05895 ENOG4105ECY inositol monophosphatase E8N14_05900 ENOG4105CVS RNA methyltransferase TrmH family, group 1 E8N14_05915 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E8N14_05920 ENOG4108Z4V iron-sulfur cluster assembly E8N14_05930 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB E8N14_05935 ENOG4108ZIT Ferredoxin, 2FE-2S E8N14_05940 ENOG4105WVQ Fe-S assembly protein IscX E8N14_05950 ENOG4105YYA enhanced serine sensitivity protein SseB E8N14_05960 ENOG4105KHC sulfurtransferase E8N14_05965 ENOG4105DN3 alpha-2-macroglobulin domain protein E8N14_05970 ENOG4108JQB penicillin-binding protein 1C E8N14_05975 ENOG4107QY8 reductase E8N14_05980 ENOG4105QAX Iron-sulfur E8N14_06020 ENOG4105N21 Membrane E8N14_06025 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E8N14_06035 ENOG4105VPD cellular component movement E8N14_06075 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E8N14_06105 ENOG41062G3 Protein of unknown function (DUF2633) E8N14_06115 ENOG4105BZU Histidine kinase E8N14_06120 ENOG4105C9X ppx gppa phosphatase E8N14_06125 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) E8N14_06130 ENOG4108V3E phosphoribosylglycinamide formyltransferase E8N14_06140 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) E8N14_06145 ENOG4105C2W permease E8N14_06155 ENOG4105K89 arsenate reductase E8N14_06160 ENOG4105ERG peptidase m48, ste24p E8N14_06165 ENOG4105C02 permease E8N14_06170 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E8N14_06175 ENOG4107QQ0 gntp family E8N14_06180 ENOG4105BZW Glycerate kinase E8N14_06185 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E8N14_06190 ENOG4105RH4 Glycine cleavage system transcriptional repressor E8N14_06195 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E8N14_06200 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E8N14_06210 ENOG4105CGZ zinc metallopeptidase E8N14_06215 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) E8N14_06225 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) E8N14_06230 ENOG4105KUZ arsenate reductase E8N14_06240 ENOG4105BZS acriflavin resistance protein E8N14_06245 ENOG4105BZU Histidine kinase E8N14_06250 ENOG4105BZ8 glutamate synthase E8N14_06260 ENOG4107VIJ nudix hydrolase E8N14_06265 ENOG4108PVD exported protein E8N14_06275 ENOG4105CV1 Transketolase (EC 2.2.1.1) E8N14_06285 ENOG4105C6K Malic enzyme E8N14_06290 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place E8N14_06295 ENOG4106S4J ethanolamine utilization protein EutP E8N14_06300 ENOG4105NDK ethanolamine utilization protein E8N14_06305 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase E8N14_06310 ENOG4108IJ2 phosphate acetyltransferase E8N14_06315 ENOG4105KNY Microcompartments protein E8N14_06320 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E8N14_06325 ENOG4108EKI Dehydrogenase E8N14_06330 ENOG4107YMV ethanolamine utilization protein E8N14_06335 ENOG4105C0A alcohol dehydrogenase E8N14_06340 ENOG4105ENY Ethanolamine utilization protein eutH E8N14_06345 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase E8N14_06350 ENOG4105CPD ethanolamine ammonia-lyase E8N14_06360 ENOG4106D67 ethanolamine utilization protein E8N14_06365 ENOG4108X49 Ethanolamine utilization protein EutK E8N14_06370 ENOG4108K3Z AraC family transcriptional regulator E8N14_06385 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase E8N14_06390 ENOG4108R6G acetyltransferase E8N14_06395 ENOG4105QZU Inner membrane protein YfeZ E8N14_06400 ENOG4105E7K (LipO)protein E8N14_06405 ENOG4105EZR dyp-type peroxidase family protein E8N14_06410 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr E8N14_06415 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein E8N14_06420 ENOG4108I5D sulfate abc transporter E8N14_06425 ENOG4105ECW sulfate abc transporter E8N14_06430 ENOG4108IJ6 ABC transporter E8N14_06435 ENOG4105C6T cysteine synthase E8N14_06445 ENOG4105M0Y E8N14_06450 ENOG41089BK Glutamine amido-transferase E8N14_06455 ENOG4105CSW GntR family transcriptional regulator E8N14_06460 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) E8N14_06470 ENOG4105C5Y PTS System E8N14_06475 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E8N14_06485 ENOG4105C6T cysteine synthase E8N14_06505 ENOG4105VRT cytoplasmic protein E8N14_06510 ENOG4105DHU Bile acid E8N14_06515 ENOG4108M0I Transcriptional regulator E8N14_06520 ENOG4108NFH Sugar hydrolase E8N14_06525 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) E8N14_06530 ENOG4105EAA nucleoside E8N14_06540 ENOG4105CN8 Transcriptional regulator E8N14_06570 ENOG4105GXM Putative transcription regulator (DUF1323) E8N14_06575 ENOG4105HZG regulatoR E8N14_06590 ENOG4108KMM Diguanylate cyclase E8N14_06595 ENOG4105D9N nucleoside E8N14_06605 ENOG4109076 Conserved Protein E8N14_06610 ENOG4105CPC Aldo Keto reductase E8N14_06615 ENOG4107RA9 decarboxylase E8N14_06630 ENOG4105CHM Aminotransferase E8N14_06640 ENOG4105D1S lipid A biosynthesis E8N14_06645 ENOG4105W9M Membrane E8N14_06650 ENOG4105CXY transporter E8N14_06655 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC E8N14_06665 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta E8N14_06670 ENOG4108NC2 Outer membrane protease E8N14_06680 ENOG4105S64 Formate nitrite transporter E8N14_06685 ENOG410903C (LipO)protein E8N14_06690 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation E8N14_06695 ENOG4105KZW UPF0381 protein E8N14_06710 ENOG4108BY2 phosphohistidine phosphatase E8N14_06720 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E8N14_06735 ENOG4105EJ9 Membrane E8N14_06740 ENOG4108BPE -transporting atpase E8N14_06745 ENOG4105MH2 YfcL protein E8N14_06750 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) E8N14_06755 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E8N14_06775 ENOG4105R8V Transcriptional regulator E8N14_06790 ENOG4106WZ1 flagella biosynthesis regulator E8N14_06800 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E8N14_06810 ENOG4105DQR SNARE associated Golgi E8N14_06820 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E8N14_06825 ENOG4108S3P Sporulation domain protein E8N14_06830 ENOG4105E96 Colicin v production protein E8N14_06835 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E8N14_06840 ENOG4108JUB Transcriptional regulator E8N14_06850 ENOG4105E5D amino acid E8N14_06855 ENOG4106M28 alanine racemase domain protein E8N14_06865 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase E8N14_06870 ENOG4105E89 ABC transporter E8N14_06875 ENOG4105E89 ABC transporter E8N14_06880 ENOG4105DSP amino acid AbC transporter E8N14_06885 ENOG4106YG3 ABC transporter E8N14_06890 ENOG4108JEH abc transporter atp-binding protein E8N14_06895 ENOG4105ECP epimerase E8N14_06900 ENOG4105CYM Glutathione S-transferase E8N14_06905 ENOG4108SHQ Glutathione S-transferase E8N14_06910 ENOG4108RE9 Phosphodiesterase E8N14_06915 ENOG4105PTV Nudix Hydrolase E8N14_06920 ENOG4105K2J Transcriptional regulator E8N14_06925 ENOG4106ETB IIa component E8N14_06935 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E8N14_06940 ENOG4108HHA Transketolase E8N14_06945 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) E8N14_06950 ENOG4105CSX c4-dicarboxylate anaerobic carrier E8N14_06955 ENOG4105C6K Malic enzyme E8N14_06960 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E8N14_06975 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 E8N14_06980 ENOG4107QWE )-transporter E8N14_06990 ENOG4105CHM Aminotransferase E8N14_06995 ENOG4107NQ8 LysR family Transcriptional regulator E8N14_07005 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain E8N14_07010 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) E8N14_07020 ENOG4105GKE subunit e E8N14_07025 ENOG4107QIZ NADH dehydrogenase E8N14_07030 ENOG4108IEH NADH dehydrogenase subunit g E8N14_07045 ENOG4107UFS subunit j E8N14_07055 ENOG4105D65 subunit l E8N14_07060 ENOG4105C8S subunit m E8N14_07080 ENOG4107YB6 acetyltransferase, (GNAT) family E8N14_07085 ENOG4105TNS Conserved Protein E8N14_07090 ENOG4105E4F Isochorismate synthase E8N14_07105 ENOG4108IPT Naphthoate synthase E8N14_07115 ENOG4105CEY Amp-dependent synthetase and ligase E8N14_07120 ENOG4106GZG polymyxin resistance protein B E8N14_07170 ENOG4108UII YfaZ family E8N14_07175 ENOG4108EWA cinA-like protein E8N14_07180 ENOG4107258 Transcriptional regulator E8N14_07190 ENOG4105CSP Major Facilitator Superfamily E8N14_07210 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) E8N14_07220 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A E8N14_07225 ENOG4105CXY transporter E8N14_07230 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E8N14_07235 ENOG4105GZI Transcriptional regulator E8N14_07240 ENOG4105CZM Major Facilitator E8N14_07245 ENOG4105XPH Ferredoxin E8N14_07250 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E8N14_07255 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E8N14_07275 ENOG4105CXK mandelate racemase muconate lactonizing E8N14_07280 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E8N14_07285 ENOG4105BZU Histidine kinase E8N14_07290 ENOG41068CG regulatoR E8N14_07295 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC E8N14_07305 ENOG4108BUD transposase E8N14_07340 ENOG4108KTG Membrane protein, drug metabolite transporter E8N14_07455 ENOG4105EMU Dehydrogenase E8N14_07465 ENOG4108BUD transposase E8N14_07485 ENOG4108BUD transposase E8N14_07505 ENOG4105I1F Resistance protein E8N14_07520 ENOG4108BUD transposase E8N14_07535 ENOG4105CJN penicillin-binding protein E8N14_07605 ENOG4108BUD transposase E8N14_07630 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E8N14_07650 ENOG4105T95 Thiol disulfide interChange protein E8N14_07825 ENOG41074AV Hok/gef family E8N14_08015 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E8N14_08030 ENOG4105F2I Transposase E8N14_08055 ENOG4106JVB Replication Protein E8N14_08090 ENOG4108YXQ IS66 Orf2 family protein E8N14_08110 ENOG4105DFE Dna adenine methylase E8N14_08135 ENOG4106JVB Replication Protein E8N14_08245 ENOG4105F2I Transposase E8N14_08295 ENOG4105C4R Atp-dependent dna helicase E8N14_08450 ENOG4108M24 von Willebrand factor, type A E8N14_08455 ENOG4108M24 von Willebrand factor, type A E8N14_08485 ENOG4105DAX Pfam:DUF2983 E8N14_08575 ENOG4105CAF HipA N-terminal domain protein E8N14_08610 ENOG4108BUD transposase E8N14_08630 ENOG4108BUD transposase E8N14_08650 ENOG4108BUD transposase E8N14_08665 ENOG4105EQR Transposase IS116 IS110 IS902 E8N14_08670 ENOG4108BUD transposase E8N14_08720 ENOG4108BUD transposase E8N14_08735 ENOG4105CJ2 (LipO)protein E8N14_08740 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E8N14_08745 ENOG4105CF1 Alkylated DNA repair protein E8N14_08750 ENOG4105IBP Cyclic peptide transporter E8N14_08760 ENOG4108ZNS ferredoxin-type protein NapF E8N14_08765 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase E8N14_08775 ENOG4108BGM Quinol dehydrogenase periplasmic component E8N14_08780 ENOG4105GXZ Ferredoxin-type protein NapH E8N14_08785 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) E8N14_08790 ENOG4105CUW cytochrome C-TYPE protein E8N14_08800 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) E8N14_08805 ENOG41060IM Heme exporter protein E8N14_08810 ENOG4105X3C heme exporter protein E8N14_08815 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) E8N14_08820 ENOG4105DA4 cytochrome c-type biogenesis protein E8N14_08825 ENOG4107QX9 Thiol disulfide interChange protein E8N14_08830 ENOG4105KWW Biogenesis protein E8N14_08835 ENOG4105WH1 Two component transcriptional regulator luxr family E8N14_08850 ENOG4108X9F tail fiber protein E8N14_08875 ENOG4105E68 Sulfatase E8N14_08900 ENOG4105CFI type iii restriction protein res subunit E8N14_08905 ENOG4105I08 Pseudouridine synthase E8N14_08910 ENOG4105C2C drug resistance transporter, Bcr CflA E8N14_08915 ENOG4105HG6 E8N14_08920 ENOG4108JQ5 ABC transporter E8N14_08925 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E8N14_08930 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E8N14_08935 ENOG4105E43 Extracellular solute-binding protein, family 5 E8N14_08940 ENOG4105CXC rtn protein E8N14_08945 ENOG4107TT5 NLP P60 protein E8N14_08950 ENOG41076MN Phosphoesterase, PA-phosphatase related E8N14_08955 ENOG4105CKI cobalamin synthesis protein E8N14_08960 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E8N14_08965 ENOG4105KRS Proteinase inhibitor E8N14_08980 ENOG4105S8Q sugar efflux transporter E8N14_08985 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E8N14_08990 ENOG4105DE4 1-phosphofructokinase E8N14_08995 ENOG4105DM4 PTS System E8N14_09005 ENOG4105HMI Membrane E8N14_09010 ENOG4105DUM transcriptional regulator, lysR family E8N14_09015 ENOG4108IQI permease E8N14_09020 ENOG4105D05 Receptor E8N14_09025 ENOG4105CXY transporter E8N14_09030 ENOG4105EAC phosphoserine phosphatase E8N14_09035 ENOG4105EJQ L-serine dehydratase E8N14_09050 ENOG4105EUJ GTP cyclohydrolase i E8N14_09055 ENOG4105DHF Membrane E8N14_09060 ENOG41060NJ transcriptional regulator E8N14_09065 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator E8N14_09070 ENOG4105C2J ABC transporter E8N14_09075 ENOG4107SDZ Galactoside transport system permease protein mglC E8N14_09080 ENOG4107SJI Dehydrogenase E8N14_09085 ENOG4105BZ8 glutamate synthase E8N14_09090 ENOG4105Y9N Membrane E8N14_09095 ENOG4107GZ4 SanA protein E8N14_09105 ENOG41067MG lrgb family E8N14_09135 ENOG4108RXX maleylacetoacetate isomerase E8N14_09140 ENOG4105MSY salicylate hydroxylase E8N14_09145 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E8N14_09155 ENOG4105ETP RND efflux system, outer membrane lipoprotein E8N14_09160 ENOG4105H9W Short-chain dehydrogenase reductase Sdr E8N14_09165 ENOG4105KHU inner membrane protein YohD E8N14_09170 ENOG41069YE inner membrane protein yohC E8N14_09175 ENOG41061WM D-Alanyl-D-Alanine E8N14_09180 ENOG4105CXG d-lactate dehydrogenase E8N14_09185 ENOG4107QK4 glycoside hydrolase, family 3 domain protein E8N14_09190 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E8N14_09195 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component E8N14_09200 ENOG4108IJ8 ABC transporter E8N14_09205 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component E8N14_09220 ENOG4108HRK Histidine kinase E8N14_09225 ENOG4108NEV two component transcriptional regulator, LytTR family E8N14_09230 ENOG4108W15 Protein of unknown function (DUF1456) E8N14_09240 ENOG4108YCW (LipO)protein E8N14_09250 ENOG4105D1F ATP-binding protein E8N14_09265 ENOG4108MQF Chaperone E8N14_09270 ENOG4105CW0 outer membrane usher protein E8N14_09275 ENOG410662B Type-1 fimbrial protein E8N14_09280 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly E8N14_09290 ENOG4105DWF phosphomethylpyrimidine kinase E8N14_09295 ENOG4105FDP GntR family transcriptional regulator E8N14_09300 ENOG4108TFM Kinase, PfkB family E8N14_09305 ENOG4108KD5 ADP-ribosylation crystallin J1 E8N14_09310 ENOG4105EAA nucleoside E8N14_09315 ENOG4105EIE fructose-bisphosphate aldolase E8N14_09330 ENOG41090V3 Tir chaperone protein (CesT) family E8N14_09340 ENOG4105CFP Peptidase U32 E8N14_09360 ENOG4105E3W Two component transcriptional regulator (Winged helix family E8N14_09365 ENOG4105EB3 Histidine kinase E8N14_09385 ENOG4105ENT Efflux transporter rnd family, mfp subunit E8N14_09395 ENOG4105R8A Heat shock protein E8N14_09400 ENOG4105D03 DNA-3-methyladenine glycosylase II E8N14_09405 ENOG4105BZU Histidine kinase E8N14_09420 ENOG4108GAE asmA family E8N14_09425 ENOG4105EE5 Membrane protein terC E8N14_09430 ENOG4105DAY polysaccharide export protein E8N14_09435 ENOG4105KJF protein tyrosine phosphatase E8N14_09440 ENOG4105D75 Capsular exopolysaccharide family E8N14_09445 ENOG41090RK glycosyl transferase E8N14_09450 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB E8N14_09455 ENOG4107RXY Glycosyl transferase E8N14_09460 ENOG4108NYJ Colanic acid E8N14_09465 ENOG4105ECJ Glycosyl Transferase E8N14_09470 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF E8N14_09475 ENOG4105C0K Gdp-mannose 4,6-dehydratase E8N14_09480 ENOG4105C30 Nad-dependent epimerase dehydratase E8N14_09485 ENOG4105FGF GDP-mannose mannosyl hydrolase E8N14_09490 ENOG4106CD9 glycosyl transferase group 1 E8N14_09495 ENOG4105CJT Mannose-1-phosphate guanylyltransferase E8N14_09500 ENOG4107QKV phosphomannomutase E8N14_09505 ENOG4105D3Q Sugar transferase E8N14_09510 ENOG4105PSV Polysaccharide Biosynthesis Protein E8N14_09515 ENOG4105C74 pyruvyl transferase E8N14_09520 ENOG4107T8Q Glycosyl transferase (Group 1 E8N14_09525 ENOG4105G1A colanic acid biosynthesis protein E8N14_09530 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E8N14_09535 ENOG4105C1B dTDP-glucose 4-6-dehydratase E8N14_09540 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase E8N14_09545 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E8N14_09550 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase E8N14_09555 ENOG4107QK7 reductase E8N14_09560 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase E8N14_09565 ENOG4105FAW cDP-glucose 4,6-dehydratase E8N14_09570 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E8N14_09605 ENOG4107T8Q Glycosyl transferase (Group 1 E8N14_09610 ENOG4105JNK Glycosyl transferase (Group 1 E8N14_09625 ENOG4105D3Q Sugar transferase E8N14_09630 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) E8N14_09635 ENOG4105C6Y Udp-glucose 6-dehydrogenase E8N14_09640 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) E8N14_09645 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E8N14_09660 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E8N14_09665 ENOG4105ECC imidazole-glycerol-phosphate dehydratase E8N14_09690 ENOG4107SRH Nad-dependent epimerase dehydratase E8N14_09695 ENOG4105EQ1 Transcriptional regulator E8N14_09705 ENOG4105CUB amino acid E8N14_09710 ENOG4105CJB Exodeoxyribonuclease I E8N14_09725 ENOG4108J2R molybdopterin oxidoreductase E8N14_09730 ENOG4105QAX Iron-sulfur E8N14_09735 ENOG4108NWD Cytochrome E8N14_09740 ENOG4105DZ1 carboxypeptidase E8N14_09745 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) E8N14_09750 ENOG4105DR8 Membrane E8N14_09755 ENOG41090HJ UPF0265 protein E8N14_09760 ENOG4105JZC GHMP kinase E8N14_09765 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E8N14_09770 ENOG4105KTW ethanolamine utilization protein E8N14_09775 ENOG4105M3W utilization protein E8N14_09785 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) E8N14_09790 ENOG4105C0A alcohol dehydrogenase E8N14_09795 ENOG4108EKI Dehydrogenase E8N14_09805 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml E8N14_09815 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) E8N14_09825 ENOG4105KNY Microcompartments protein E8N14_09835 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E8N14_09840 ENOG4108ZFT Dehydratase small subunit E8N14_09845 ENOG4105YCI dehydratase medium subunit E8N14_09850 ENOG4105DMB glycerol dehydratase E8N14_09855 ENOG4105EHR propanediol utilization protein pduB E8N14_09860 ENOG4105KNY Microcompartments protein E8N14_09865 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E8N14_09870 ENOG4107XVH Transcriptional regulator E8N14_09875 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) E8N14_09885 ENOG41081F0 Precorrin-8x methylmutase E8N14_09895 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase E8N14_09900 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase E8N14_09905 ENOG4105CIA precorrin-4 C(11)-methyltransferase E8N14_09910 ENOG4108P62 biosynthesis protein (CbiG) E8N14_09915 ENOG4105E4R Precorrin-3B C17-methyltransferase E8N14_09920 ENOG4105QUC reductase E8N14_09925 ENOG4107PPM cobalt chelatase E8N14_09930 ENOG4105DVK Precorrin-2 c20-methyltransferase E8N14_09935 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E8N14_09940 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) E8N14_09945 ENOG4108V4M Cobalt abc transporter E8N14_09950 ENOG4108JJB ABC transporter E8N14_09960 ENOG4108YZT Adenosylcobinamide kinase E8N14_09975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E8N14_09985 ENOG41085FC arsR family transcriptional regulator E8N14_09990 ENOG4108UXE Protein tyrosine phosphatase E8N14_10005 ENOG4105D6J arsenicaL-resistance protein E8N14_10020 ENOG4105UQX Mate efflux family protein E8N14_10035 ENOG4105FYV Amp nucleosidase E8N14_10120 ENOG4105KT5 UmuD protein E8N14_10125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E8N14_10140 ENOG4105FCK Membrane E8N14_10145 ENOG4105Y0K Inner membrane protein YedR E8N14_10150 ENOG4105EST Metal Dependent Phosphohydrolase E8N14_10155 ENOG4105DVF Cytosine-specific methyltransferase E8N14_10160 ENOG41090BB DNA mismatch endonuclease (vsr) E8N14_10165 ENOG4105FDR Membrane E8N14_10170 ENOG4105CKW Inner membrane protein yedI E8N14_10175 ENOG4105VNZ cytoplasmic protein E8N14_10185 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase E8N14_10195 ENOG4105YX3 cellular response to acidity E8N14_10205 ENOG4107TKS colanic acid capsular biosynthesis activation protein A E8N14_10210 ENOG4105D19 Role in flagellar biosynthesis (By similarity) E8N14_10215 ENOG4105VS8 Flagellar biosynthetic protein fliq E8N14_10220 ENOG4105CN7 Flagellar biosynthetic protein FliP E8N14_10225 ENOG4105K0P flagellar biosynthesis protein E8N14_10230 ENOG4105DD5 Flagellar motor switch protein E8N14_10235 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E8N14_10240 ENOG4107ZI8 flagellar basal body-associated protein flil E8N14_10245 ENOG4105WF4 Flagellar hook-length control protein E8N14_10250 ENOG4105GSA Flagellar export protein flij E8N14_10255 ENOG4108JIR Flagellum-specific ATP synthase E8N14_10260 ENOG41090PJ Flagellar assembly protein E8N14_10265 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) E8N14_10270 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) E8N14_10290 ENOG41066VF YeeE YedE family protein E8N14_10295 ENOG4105JCU Inherit from NOG: (Lipo)protein E8N14_10300 ENOG4105E5K Alpha-amylase E8N14_10310 ENOG4105MQ3 flagellar protein FliS E8N14_10315 ENOG4105DTS flagellar hook-associated E8N14_10330 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E8N14_10335 ENOG4108M9K flagella biosynthesis protein FliZ E8N14_10340 ENOG4105EAB amino acid AbC transporter E8N14_10350 ENOG4105E5Q amino acid AbC transporter E8N14_10355 ENOG4105CDA abc transporter atp-binding protein E8N14_10360 ENOG4105VJY transcriptional regulator E8N14_10365 ENOG4105XVG cytoplasmic protein E8N14_10375 ENOG4105WH1 Two component transcriptional regulator luxr family E8N14_10420 ENOG4106RHG Yeca family E8N14_10425 ENOG4105E0U tyrosine-specific transport protein E8N14_10430 ENOG4105VVZ metal-binding protein E8N14_10435 ENOG41090A1 ferritin E8N14_10440 ENOG4105P23 (LipO)protein E8N14_10450 ENOG4108UEC Ferritin-like protein E8N14_10465 ENOG4108K4C ec 3.1.3.12 E8N14_10475 ENOG4108VA4 Universal stress protein E8N14_10485 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) E8N14_10490 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region E8N14_10495 ENOG4107RD7 Flagellar Motor Protein, MotA E8N14_10500 ENOG4105ER2 Ompa motb domain protein E8N14_10505 ENOG4105CBS Chea signal transduction histidine kinase E8N14_10510 ENOG4108V3W Chemotaxis protein, CheW E8N14_10515 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_10520 ENOG4105BZU Histidine kinase E8N14_10530 ENOG4108VYJ response regulator receiver protein E8N14_10535 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) E8N14_10540 ENOG4105D00 flagellar biosynthetic protein flhB E8N14_10545 ENOG4105D7B Flagellar biosynthesis protein flha E8N14_10550 ENOG4105IRD Flagellar protein FlhE E8N14_10555 ENOG4105F5H Glycosyl Hydrolase Family 88 E8N14_10570 ENOG4106ZCM YecM protein E8N14_10590 ENOG4105WJG Glutathione E8N14_10595 ENOG41081XQ Conserved Protein E8N14_10600 ENOG4105D3W isochorismatase E8N14_10610 ENOG4108TIT dATP pyrophosphohydrolase E8N14_10615 ENOG4105CDY transcriptional regulatory protein E8N14_10625 ENOG4107S01 Repressor protein MetJ E8N14_10645 ENOG4105FAV ABC, transporter E8N14_10655 ENOG4105NXV High-affinity zinc uptake system protein E8N14_10660 ENOG4105DR5 peptidase E8N14_10665 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase E8N14_10670 ENOG4105CA9 Pyruvate kinase E8N14_10675 ENOG4106KNT transcriptional regulator E8N14_10680 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E8N14_10685 ENOG4105C01 Dihydroxy-acid dehydratase E8N14_10690 ENOG4108UHU Aldolase E8N14_10700 ENOG4105X2V dna damage-inducible protein E8N14_10710 ENOG4108Q2J Inner membrane protein YebE E8N14_10715 ENOG4105CUG Oligopeptidase b E8N14_10720 ENOG4105UMD exodeoxyribonuclease X E8N14_10725 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E8N14_10730 ENOG4105MPK DNA polymerase III subunit theta E8N14_10735 ENOG4105FXM Copper resistance protein E8N14_10740 ENOG4108PNC copper resistance E8N14_10745 ENOG4105NKT exported protein E8N14_10750 ENOG4108I1J Integrase E8N14_10785 ENOG4105UZW Tail fiber assembly protein E8N14_10825 ENOG4105DWP Membrane E8N14_10900 ENOG41064WM Uncharacterized protein YcgX E8N14_10905 ENOG4106EWC guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling E8N14_10915 ENOG4108R1E Serine threonine protein phosphatase 1 E8N14_10920 ENOG4105UVW uncharacterized protein yebW E8N14_10925 ENOG4105WT8 Protein of unknown function (DUF1480) E8N14_10935 ENOG4105DY2 Paraquat-inducible protein b E8N14_10940 ENOG4105H2K paraquat-inducible protein a E8N14_10945 ENOG4108ZGC gaf domain protein E8N14_10955 ENOG4105CN1 protease E8N14_10960 ENOG4105D0M Protease HtpX homolog E8N14_10965 ENOG4105C0R drug resistance transporter emrb qaca subfamily E8N14_10970 ENOG4105J4Q Transcriptional regulator E8N14_10980 ENOG4106CCY Protein MgrB homolog E8N14_10985 ENOG4105Q3Y exported protein E8N14_11000 ENOG4105CJN penicillin-binding protein E8N14_11005 ENOG4105DHI Methyltransferase E8N14_11020 ENOG4105F3R pts system mannose fructose sorbose family iid E8N14_11025 ENOG4105ETZ PTS System E8N14_11030 ENOG4105DAS pts system E8N14_11035 ENOG4105EE5 Membrane protein terC E8N14_11040 ENOG4107XTP (EAL) domain protein E8N14_11045 ENOG4105EJQ L-serine dehydratase E8N14_11055 ENOG4105CRQ synthase (Component I) E8N14_11060 ENOG4105X5C UPF0181 protein E8N14_11065 ENOG4105M4H endoribonuclease L-psp E8N14_11070 ENOG4105DVT helicase E8N14_11075 ENOG41072GX Peptidase M22 Glycoprotease E8N14_11080 ENOG4105Y4Z Outer Membrane Lipoprotein E8N14_11085 ENOG4105CEY Amp-dependent synthetase and ligase E8N14_11090 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) E8N14_11100 ENOG4107QMS site-determining protein E8N14_11115 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E8N14_11130 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation E8N14_11140 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) E8N14_11155 ENOG4105ED1 spovr family E8N14_11165 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E8N14_11175 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A E8N14_11185 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) E8N14_11200 ENOG4105D82 Glutamate dehydrogenase E8N14_11210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E8N14_11215 ENOG4105C4M (Ubiquinol oxidase) subunit I E8N14_11220 ENOG4105MVP hydrogenase-1 operon protein HyaF E8N14_11225 ENOG4108VXY Hydrogenase-1 operon protein HyaE E8N14_11230 ENOG4108USZ hydrogenase E8N14_11235 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E8N14_11245 ENOG4105E3S small subunit E8N14_11265 ENOG4105C3G gtp-binding protein E8N14_11275 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria E8N14_11280 ENOG4105CHH sulfate transporter E8N14_11285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E8N14_11290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) E8N14_11300 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) E8N14_11310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E8N14_11315 ENOG4108YY7 Invasion gene expression up-regulator SirB E8N14_11320 ENOG41063JG Transcriptional regulator E8N14_11330 ENOG4105EWV Sodium calcium exchanger membrane region E8N14_11335 ENOG4105WS7 Cation transport regulator E8N14_11340 ENOG41090EX DsrE family E8N14_11345 ENOG4105ID0 Putative invasin E8N14_11350 ENOG4105WH1 Two component transcriptional regulator luxr family E8N14_11355 ENOG4105BZU Histidine kinase E8N14_11360 ENOG4105DQQ Major facilitator superfamily MFS_1 E8N14_11365 ENOG4105CRU nitrate reductase, alpha subunit E8N14_11370 ENOG4108IUE nitrate reductase beta subunit E8N14_11375 ENOG4105R3A Nitrate reductase E8N14_11380 ENOG41076YT nitrate reductase, gamma subunit E8N14_11410 ENOG4105CIY formyltetrahydrofolate deformylase E8N14_11420 ENOG4105D78 K07001 NTE family protein E8N14_11425 ENOG4105I93 response regulator E8N14_11430 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E8N14_11445 ENOG4105C0A alcohol dehydrogenase E8N14_11450 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein E8N14_11455 ENOG4107QSI ABC, transporter E8N14_11460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E8N14_11465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E8N14_11470 ENOG4105C3U ABC transporter E8N14_11475 ENOG4108JQ7 (ABC) transporter E8N14_11480 ENOG4105EYW Ion transport protein E8N14_11500 ENOG4105K9H YciI-like protein E8N14_11505 ENOG410822N TonB family E8N14_11510 ENOG4105NAU thioesterase Superfamily protein E8N14_11525 ENOG4105PI0 Ferredoxin E8N14_11530 ENOG4105EIF outer membrane protein W E8N14_11535 ENOG4105WEF catalase E8N14_11540 ENOG4108N8X transition metal ion binding E8N14_11545 ENOG4108Z9Z response to DNA damage stimulus E8N14_11565 ENOG4105DK0 Indole-3-glycerol phosphate synthase E8N14_11570 ENOG4108EFP Anthranilate synthase component II E8N14_11575 ENOG4105CRQ synthase (Component I) E8N14_11585 ENOG4105DB7 PHP domain protein E8N14_11590 ENOG4107RTD sua5 ycio yrdc ywlc family protein E8N14_11595 ENOG4105FE9 pseudouridine synthase E8N14_11600 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase E8N14_11605 ENOG4105UBK short-chain dehydrogenase reductase E8N14_11610 ENOG4105ERU peptidase E8N14_11615 ENOG4105RKX Protein of unknown function (DUF2498) E8N14_11620 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E8N14_11630 ENOG4107R11 Transcriptional regulator E8N14_11645 ENOG4107QM5 aconitate hydratase E8N14_11650 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) E8N14_11655 ENOG4105EYK Phosphatidylglycerophosphatase B E8N14_11660 ENOG4105Q4A inner membrane protein yciS E8N14_11665 ENOG4105CFV Tetratricopeptide repeat protein E8N14_11675 ENOG4108ZJT translation initiation factor, Sui1 E8N14_11680 ENOG41061RM osmotically inducible lipoprotein E8N14_11685 ENOG4105N2W Transcriptional regulator E8N14_11695 ENOG4105BZU Histidine kinase E8N14_11705 ENOG4105Q4T oxidoreductase E8N14_11710 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E8N14_11735 ENOG4108JQ2 peptide transport system atp-binding protein E8N14_11740 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein E8N14_11745 ENOG4108EU3 peptide transport system, permease E8N14_11750 ENOG4108EKA peptide transport system, permease E8N14_11755 ENOG4108J59 Extracellular solute-binding protein, family 5 E8N14_11760 ENOG4105E51 psp operon transcriptional activator E8N14_11765 ENOG41087YS Phage shock protein A E8N14_11770 ENOG4105YYT phage shock protein B E8N14_11775 ENOG4105FM1 phage shock protein C E8N14_11780 ENOG4105NNG Peripheral inner membrane phage-shock protein E8N14_11785 ENOG4105K8Z Phage shock protein E8N14_11790 ENOG4105CM6 amino acid regulated cytosolic protein E8N14_11800 ENOG4108JU8 Transcriptional regulator E8N14_11805 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E8N14_11810 ENOG4107S8C mandelate racemase muconate lactonizing E8N14_11815 ENOG4105KXI murein peptide amidase A E8N14_11820 ENOG4107QSI ABC, transporter E8N14_11830 ENOG4105HEI LysR family (Transcriptional regulator E8N14_11835 ENOG4105CV8 reductase E8N14_11840 ENOG4105F6U Short-chain dehydrogenase reductase Sdr E8N14_11845 ENOG4108XFH Transcriptional regulator E8N14_11860 ENOG4106PHM regulatory protein E8N14_11880 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E8N14_11900 ENOG4105D64 Mechanosensitive ion channel E8N14_11905 ENOG4105S5I Membrane E8N14_11910 ENOG4105Q9Y Universal stress protein E8N14_11915 ENOG4105DS0 Transcriptional regulator, Crp Fnr family E8N14_11920 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E8N14_11925 ENOG4108DG9 Smr protein MutS2 E8N14_11930 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_11945 ENOG4105C1J atp-dependent rna helicase E8N14_11960 ENOG410814C multidrug resistance protein E8N14_11965 ENOG4108RW8 Universal stress protein F E8N14_11970 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) E8N14_11980 ENOG4105IKK cytoplasmic protein E8N14_11985 ENOG41090X5 Heat shock protein hslJ E8N14_11990 ENOG4105C5I Dehydrogenase E8N14_11995 ENOG4107H52 Dicarboxylate transport E8N14_12000 ENOG410689M (LipO)protein E8N14_12005 ENOG4105WXT Conserved Protein E8N14_12020 ENOG4105CQ7 ATP-dependent helicase E8N14_12025 ENOG4107DB1 DUF218 domain E8N14_12030 ENOG4105CPW cytochrome b561 E8N14_12035 ENOG4108WF3 methyltransferase E8N14_12045 ENOG4105E5Q amino acid AbC transporter E8N14_12055 ENOG4105E5Q amino acid AbC transporter E8N14_12060 ENOG4107R0W ABC transporter E8N14_12070 ENOG4107ZUJ lipid metabolic process E8N14_12095 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_12100 ENOG4105DDW LysR family Transcriptional regulator E8N14_12105 ENOG4105E32 cytoplasmic protein E8N14_12110 ENOG4105EBR Carboxylesterase E8N14_12120 ENOG4108YYC ycei family E8N14_12135 ENOG4108PQ7 sgc region transcriptional regulator E8N14_12140 ENOG4108RK0 3-epimerase E8N14_12145 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E8N14_12150 ENOG4106P19 photosystem i assembly btpa E8N14_12155 ENOG4105DT3 PTS system, galactitol-specific IIc component E8N14_12160 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E8N14_12165 ENOG4105CN9 Peptidase m42 family protein E8N14_12170 ENOG4108Z9I -acetyltransferase E8N14_12175 ENOG4107WE3 acetyltransferase YdcK E8N14_12180 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein E8N14_12185 ENOG41088CC tellurite resistance protein tehB E8N14_12190 ENOG4108KKZ (LipO)protein E8N14_12195 ENOG4105DKK Benzoate E8N14_12200 ENOG4108JCI Transcriptional regulator E8N14_12205 ENOG4105CFP Peptidase U32 E8N14_12210 ENOG4105RR0 Protein of unknown function (DUF2554) E8N14_12230 ENOG4108UQS dipeptidase E8N14_12235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E8N14_12250 ENOG410654E Membrane E8N14_12270 ENOG4105R71 cytoplasmic protein E8N14_12275 ENOG4108T9Y Inner membrane protein ydcZ E8N14_12280 ENOG4108Z7F N-acetyltransferase E8N14_12285 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E8N14_12290 ENOG4108WYP Transcriptional regulator E8N14_12295 ENOG4105CHB tonB-dependent Receptor E8N14_12300 ENOG4108NS2 receptor E8N14_12305 ENOG4105SUV lipoprotein YgdR E8N14_12310 ENOG4105C85 amino acid E8N14_12325 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase E8N14_12330 ENOG4105JAB phenazine biosynthesis protein, phzf family E8N14_12335 ENOG4105D0D Nitrate reductase 2, gamma subunit E8N14_12340 ENOG4108NZN Respiratory nitrate reductase 2 delta chain E8N14_12345 ENOG4108IUE nitrate reductase beta subunit E8N14_12350 ENOG4105CRU nitrate reductase, alpha subunit E8N14_12355 ENOG4107QND Nitrite extrusion protein E8N14_12390 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E8N14_12395 ENOG4108MG3 formate dehydrogenase E8N14_12400 ENOG4105DQ4 alcohol dehydrogenase E8N14_12415 ENOG4105TPS biofilm-dependent modulation protein E8N14_12420 ENOG4108Z9K Osmotically inducible protein E8N14_12425 ENOG4105XXV Acid-resistance protein E8N14_12435 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) E8N14_12450 ENOG4105C87 Aminotransferase class I and II E8N14_12455 ENOG4105DFD Na H antiporter E8N14_12460 ENOG41060NJ transcriptional regulator E8N14_12490 ENOG4108UQ8 endoribonuclease L-psp E8N14_12495 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) E8N14_12520 ENOG4108I5G Major Facilitator superfamily E8N14_12525 ENOG4105CPQ Dehydrogenase E8N14_12530 ENOG4105C6F GntR Family Transcriptional Regulator E8N14_12545 ENOG4105DPX Hydrogenase, large subunit E8N14_12550 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit E8N14_12570 ENOG4105MVP hydrogenase-1 operon protein HyaF E8N14_12595 ENOG4105FFC UPF0187 protein E8N14_12600 ENOG4105M0C cytoplasmic protein E8N14_12610 ENOG4105C26 Dehydrogenase E8N14_12615 ENOG4105EGI Transcriptional regulator E8N14_12630 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes E8N14_12635 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF E8N14_12640 ENOG4106DNR multiple antibiotic resistance protein E8N14_12645 ENOG4108594 Permease of the drug metabolite transporter E8N14_12650 ENOG4105E5W Transporter E8N14_12660 ENOG4108YDI single-species biofilm formation on inanimate substrate E8N14_12665 ENOG4108WTK competence damage-inducible protein E8N14_12680 ENOG4105DGW oligopeptidase A E8N14_12685 ENOG4105EMU Dehydrogenase E8N14_12690 ENOG4107XBN GntR Family Transcriptional Regulator E8N14_12695 ENOG41061EV selenium-binding protein YdfZ E8N14_12700 ENOG4105DEI Mannitol dehydrogenase E8N14_12710 ENOG4105CPQ Dehydrogenase E8N14_12730 ENOG4108MK9 spermidine N(1)-acetyltransferase E8N14_12740 ENOG4105KBG Protein of unknown function (DUF1161) E8N14_12745 ENOG4107QY8 reductase E8N14_12750 ENOG4105C3J Cysteine desulfurase E8N14_12755 ENOG4105QAX Iron-sulfur E8N14_12760 ENOG4107KGK dmso reductase anchor subunit E8N14_12765 ENOG4108NEM leader-binding protein dmsD E8N14_12770 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component E8N14_12775 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system E8N14_12780 ENOG4105E90 ABC transporter E8N14_12785 ENOG4108IJ8 ABC transporter E8N14_12795 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E8N14_12800 ENOG4105DAG ROK family E8N14_12805 ENOG4106NZI LysR family Transcriptional regulator E8N14_12810 ENOG4105D94 Major Facilitator Superfamily E8N14_12820 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap E8N14_12840 ENOG4105DSF transport protein E8N14_12845 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E8N14_12850 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E8N14_12855 ENOG4105C5D exported protein E8N14_12860 ENOG4105D5Q Arginine ornithine antiporter E8N14_12865 ENOG4105RA2 Membrane E8N14_12870 ENOG4107EXC regulatoR E8N14_12880 ENOG4105FCK Membrane E8N14_12885 ENOG4105CPN adenine deaminase E8N14_12890 ENOG4105JJR Histidine kinase E8N14_12900 ENOG4105C9Q fumarate hydratase class II E8N14_12905 ENOG4107GFK fumarate E8N14_12910 ENOG4105EIP mannose-6-phosphate isomerase E8N14_12915 ENOG4106J39 exported protein E8N14_12920 ENOG4105CI1 PTS System E8N14_12930 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E8N14_12935 ENOG4105D9R oxidoreductase E8N14_12940 ENOG4106C6R beta-lactam resistance protein E8N14_12950 ENOG4105M9B inner membrane protein ydgK E8N14_12975 ENOG4108UQQ Electron transport complex E8N14_12985 ENOG4105CSM endonuclease III E8N14_12990 ENOG4105DUX Transporter E8N14_12995 ENOG4108K3A Glutathione S-transferase E8N14_13015 ENOG410642K Lysozyme inhibitor E8N14_13025 ENOG4108XTF Outer Membrane Lipoprotein E8N14_13040 ENOG4105Y49 secretion protein, HlyD family E8N14_13045 ENOG4105DSW Fusaric acid resistance protein E8N14_13050 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E8N14_13055 ENOG4107RGM aldo keto reductase E8N14_13060 ENOG4105XZD Fe-S protein E8N14_13065 ENOG4108WUH Transcriptional regulator, TetR family E8N14_13070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E8N14_13075 ENOG4108UYE Lactoylglutathione lyase E8N14_13080 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E8N14_13090 ENOG4105M2J Glutaredoxin E8N14_13095 ENOG4105K4H Nlp p60 protein E8N14_13100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E8N14_13115 ENOG4105F52 Transcriptional regulator E8N14_13120 ENOG4105CZQ inner membrane transport protein YdhC E8N14_13125 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E8N14_13130 ENOG4108R6K riboflavin synthase, subunit alpha E8N14_13150 ENOG4108IUF type iii secretion E8N14_13155 ENOG4108TN6 type iii secretion E8N14_13160 ENOG41083GP type iii secretion E8N14_13165 ENOG4108HHI Type III secretion system protein E8N14_13170 ENOG41063Q7 Type III secretion system protein E8N14_13185 ENOG4108JIR Flagellum-specific ATP synthase E8N14_13195 ENOG4106H1D secretion system apparatus protein E8N14_13200 ENOG4105UQF type iii secretion E8N14_13205 ENOG4106563 type III secretion system apparatus protein E8N14_13255 ENOG4106FZW pathogenicity island effector protein E8N14_13260 ENOG4108SZ7 secretion system effector E8N14_13270 ENOG4105ZQI secreted protein E8N14_13300 ENOG4105BZU Histidine kinase E8N14_13310 ENOG4108XDN Transcriptional regulator E8N14_13315 ENOG4107SEY Conserved Protein E8N14_13320 ENOG4105RFR Protein of unknown function (DUF2767) E8N14_13325 ENOG4108ZXC Two component transcriptional regulator, luxr family E8N14_13330 ENOG4106AFQ Histidine kinase E8N14_13340 ENOG4106WHD Tetrathionate reductase E8N14_13345 ENOG4105DB1 molybdopterin oxidoreductase E8N14_13350 ENOG4108RVA ribokinase E8N14_13360 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) E8N14_13365 ENOG4105CUB amino acid E8N14_13370 ENOG4105CA9 Pyruvate kinase E8N14_13380 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E8N14_13395 ENOG4105JRK feS assembly protein SufD E8N14_13400 ENOG4105C3K feS assembly ATPase SufC E8N14_13405 ENOG4105DIW FeS assembly protein SUFB E8N14_13410 ENOG4108Z4V iron-sulfur cluster assembly E8N14_13415 ENOG4108ETY sodium dicarboxylate symporter E8N14_13420 ENOG410671Z uncharacterized protein ydiH E8N14_13425 ENOG4105KA0 thioesterase Superfamily protein E8N14_13430 ENOG4105CQB FAD linked oxidase domain protein E8N14_13435 ENOG4105IPI Membrane E8N14_13445 ENOG4105SUA Ydil protein E8N14_13450 ENOG4105EMV Major Facilitator E8N14_13455 ENOG4105EMV Major Facilitator E8N14_13470 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E8N14_13475 ENOG4105C1G acyl-Coa dehydrogenase E8N14_13480 ENOG4105W4W Transcriptional regulator E8N14_13485 ENOG4105CV7 Electron transfer flavoprotein E8N14_13490 ENOG4105C10 Electron transfer flavoprotein E8N14_13495 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E8N14_13500 ENOG41090P5 ferredoxin-like protein E8N14_13505 ENOG4105CEY Amp-dependent synthetase and ligase E8N14_13510 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) E8N14_13520 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E8N14_13540 ENOG4108QBX (LipO)protein E8N14_13550 ENOG4108V06 Glutathione peroxidase E8N14_13560 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E8N14_13565 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E8N14_13585 ENOG41082NX 50s ribosomal protein l35 E8N14_13590 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) E8N14_13615 ENOG4108NE3 Salt-induced outer membrane protein E8N14_13620 ENOG4105DE4 1-phosphofructokinase E8N14_13625 ENOG4105P10 Uncharacterized protein ydiZ E8N14_13635 ENOG4107PN8 YfeABCD locus regulator E8N14_13640 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 E8N14_13645 ENOG4107K5X Membrane-bound metal-dependent hydrolase E8N14_13650 ENOG4108ETY sodium dicarboxylate symporter E8N14_13660 ENOG4105CH6 catalase E8N14_13670 ENOG4105F8D glycoside hydrolase family 4 E8N14_13675 ENOG4105EZV Transcriptional regulator E8N14_13680 ENOG4105VCP PTS System E8N14_13685 ENOG4105CK1 PTS System E8N14_13690 ENOG4105VZJ PTS System E8N14_13700 ENOG4105KKI DNA-binding transcriptional activator OsmE E8N14_13710 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) E8N14_13715 ENOG4108SPG Periplasmic Protein E8N14_13745 ENOG4105CGK Exodeoxyribonuclease III E8N14_13750 ENOG4105M6F mutator MutT protein E8N14_13755 ENOG4105MTM Protein of unknown function (DUF1496) E8N14_13760 ENOG4105D82 Glutamate dehydrogenase E8N14_13765 ENOG4108IYH Dna topoisomerase E8N14_13770 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) E8N14_13775 ENOG41069NU Nitroreductase E8N14_13780 ENOG4105D07 Signal peptide peptidase, SppA E8N14_13785 ENOG4105HDK L-asparaginase E8N14_13790 ENOG4108RWI nicotinamidase E8N14_13795 ENOG4105VUT cytoplasmic protein E8N14_13805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E8N14_13810 ENOG4105DSB aldose 1-epimerase E8N14_13815 ENOG4105CV8 reductase E8N14_13820 ENOG4105C4X radical SAM domain protein E8N14_13825 ENOG4105GNX MltA-interacting MipA family protein E8N14_13830 ENOG4105CYN Serine protein kinase E8N14_13845 ENOG4108KHP Diguanylate cyclase E8N14_13850 ENOG4108KXH Ybak prolyl-tRNA synthetase associated E8N14_13865 ENOG4105R1U AraC Family Transcriptional Regulator E8N14_13870 ENOG4105DJ2 Major Facilitator Superfamily E8N14_13875 ENOG4105K78 MarR family Transcriptional regulator E8N14_13885 ENOG4105UCG Domain of unknown function (DUF333) E8N14_13890 ENOG4106G4W E8N14_13895 ENOG4105Y3U Transglycosylase-associated protein E8N14_13910 ENOG4105YP6 Domain of unknown function (DUF1869) E8N14_13915 ENOG4108YS1 cytoplasmic protein E8N14_13925 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E8N14_13940 ENOG4108Z6Z Transcriptional regulator E8N14_13955 ENOG4108MEK Metal-binding protein YodA E8N14_13970 ENOG4105D64 Mechanosensitive ion channel E8N14_13975 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E8N14_13980 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) E8N14_14005 ENOG4108VKM cytochrome b561 E8N14_14015 ENOG4108ZNX Heat shock protein E8N14_14040 ENOG4105H38 Membrane E8N14_14055 ENOG41060EU Cold shock-like protein E8N14_14060 ENOG4106F2Y RICIN E8N14_14065 ENOG4105Y50 Virulence Protein E8N14_14085 ENOG4108HMX isocitrate dehydrogenase (NADP) E8N14_14090 ENOG4108R99 pseudouridine synthase E8N14_14115 ENOG4107QTF adenylosuccinate lyase E8N14_14130 ENOG4105EZE Cupin 4 family protein E8N14_14145 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E8N14_14160 ENOG4105D38 putrescine abc transporter E8N14_14165 ENOG4108HM4 ABC transporter E8N14_14170 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E8N14_14180 ENOG4105D60 lipoprotein releasing system transmembrane protein E8N14_14185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E8N14_14190 ENOG4105D60 lipoprotein releasing system transmembrane protein E8N14_14195 ENOG4108JA2 transcriptioN-repair coupling factor E8N14_14200 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E8N14_14205 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction E8N14_14210 ENOG4108IND Tetr family transcriptional regulator E8N14_14215 ENOG4107MBR 17 kDa surface antigen E8N14_14220 ENOG4105CEP NADH dehydrogenase E8N14_14240 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) E8N14_14245 ENOG41090DQ Lipoprotein E8N14_14250 ENOG4105K59 histidine triad (HIT) protein E8N14_14260 ENOG4105CI1 PTS System E8N14_14265 ENOG4105F8V Hydrolase, tatD family E8N14_14270 ENOG4107QRG dna polymerase iii E8N14_14280 ENOG4105HHA aminodeoxychorismate lyase E8N14_14285 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E8N14_14290 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) E8N14_14295 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) E8N14_14300 ENOG4105CHR reductase E8N14_14305 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E8N14_14325 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E8N14_14330 ENOG4108UHJ MAF-like protein E8N14_14345 ENOG4105EI2 Pseudouridine synthase E8N14_14350 ENOG41071G1 Uncharacterized protein YceQ E8N14_14355 ENOG4107QQB Ribonuclease E E8N14_14360 ENOG4105DTJ flagellar hook-associated protein E8N14_14365 ENOG4105E1Q flagellar hook-associated protein E8N14_14370 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj E8N14_14385 ENOG4105CGA flagellar basal-body rod protein FlgG E8N14_14390 ENOG4108KPB Flagellar basal-body rod protein FlgF E8N14_14395 ENOG4105BZE flagellar hook protein, FlgE E8N14_14400 ENOG4105W00 Flagellar hook capping protein E8N14_14405 ENOG4108ZC9 flagellar basal-body rod protein flgc E8N14_14410 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) E8N14_14415 ENOG4105CKS Flagella basal body P-ring formation protein flgA E8N14_14420 ENOG4105M9M anti-sigma28 factor FlgM E8N14_14425 ENOG4105QVD Flagella synthesis protein FlgN E8N14_14430 ENOG4105CJR Integral membrane protein (MviN E8N14_14435 ENOG4105EP9 oxidoreductase E8N14_14445 ENOG4105D9U N-acetyltransferase E8N14_14455 ENOG4105E9S glutaredoxin 2 E8N14_14460 ENOG4105F3T (LipO)protein E8N14_14470 ENOG4105MEA DNA damage-inducible protein i E8N14_14475 ENOG4105PVA Biofilm formation regulatory protein BssS E8N14_14485 ENOG4106974 biofilm formation E8N14_14490 ENOG4105DS1 cytochrome b561 E8N14_14505 ENOG4105D1S lipid A biosynthesis E8N14_14515 ENOG4108W47 Acidic protein msyB E8N14_14520 ENOG4105NAC (LipO)protein E8N14_14525 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) E8N14_14540 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) E8N14_14545 ENOG4107RZC phospholipase d E8N14_14555 ENOG41068SS E8N14_14560 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) E8N14_14565 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin E8N14_14570 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers E8N14_14575 ENOG41086KC Transcriptional regulator E8N14_14580 ENOG4108XDW curli assembly protein CsgE E8N14_14585 ENOG4108WYR Curli production assembly transport component, CsgF E8N14_14590 ENOG4105P8Q Curli production assembly transport component CsgG E8N14_14595 ENOG4108UQ5 membrane protein YcdZ E8N14_14600 ENOG4107XHZ cytoplasmic chaperone TorD family protein E8N14_14625 ENOG4107RJ5 oxidoreductase E8N14_14630 ENOG4105JHE Major Facilitator Superfamily E8N14_14635 ENOG4108QGT oligogalacturonate-specific porin E8N14_14645 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) E8N14_14650 ENOG4107RJ1 sodium solute E8N14_14655 ENOG4105QEK Transcriptional regulator E8N14_14660 ENOG4105D5M phosphate starvation-inducible protein E8N14_14665 ENOG4105CK7 Sodium proline symporter E8N14_14680 ENOG4108R86 Transcriptional regulator E8N14_14685 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 E8N14_14690 ENOG4105CS1 NAD(P)H quinone oxidoreductase E8N14_14695 ENOG4105XH3 E8N14_14700 ENOG4105D6F Phosphatase E8N14_14705 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E8N14_14710 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E8N14_14715 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E8N14_14775 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase E8N14_14780 ENOG4105C26 Dehydrogenase E8N14_14790 ENOG4108V8F Transcriptional regulator, MarR family E8N14_14795 ENOG4105EFA 4-hydroxyphenylacetate E8N14_14800 ENOG4107UWN reductase E8N14_14805 ENOG4105VT2 5-hydroxyisourate hydrolase E8N14_14810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E8N14_14815 ENOG4107ZY3 Histidine kinase E8N14_14830 ENOG4106YSC E8N14_14835 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell E8N14_14840 ENOG4106HNN Invasion protein E8N14_14850 ENOG41084BJ Pentapeptide repeat protein E8N14_14865 ENOG4108MN8 Membrane E8N14_14875 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 E8N14_14885 ENOG4108V1U phospholipid-binding protein E8N14_14900 ENOG4105K4P CoA-binding domain protein E8N14_14910 ENOG4108Z5K methylglyoxal synthase E8N14_14915 ENOG41088T4 Helicase IV E8N14_14920 ENOG410901E Membrane E8N14_14925 ENOG4105EM2 membrane E8N14_14930 ENOG4108RZ1 DNA transformation protein E8N14_14940 ENOG4105UYK outer membrane protein a E8N14_14950 ENOG4105DAN ATP-dependent protease E8N14_14960 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) E8N14_14965 ENOG4108Q2G (LipO)protein E8N14_14970 ENOG4105DY2 Paraquat-inducible protein b E8N14_14975 ENOG4105F1S paraquat-inducible protein a E8N14_14980 ENOG4105C5H ABC transporter E8N14_14990 ENOG4105QVC MOSC domain-containing protein E8N14_14995 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) E8N14_15005 ENOG4105CD8 aminopeptidase N E8N14_15010 ENOG4105Y50 Virulence Protein E8N14_15030 ENOG4105UZW Tail fiber assembly protein E8N14_15035 ENOG4108X9F tail fiber protein E8N14_15100 ENOG4105D7V transposase E8N14_15115 ENOG4105IM0 capsid protein E8N14_15135 ENOG4107DE1 head-to-tail joining protein E8N14_15140 ENOG4105UZW Tail fiber assembly protein E8N14_15150 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium E8N14_15155 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 E8N14_15185 ENOG4105HGD Antitermination protein E8N14_15225 ENOG4105JBR DNA replication protein E8N14_15270 ENOG41076J9 exonuclease VIII E8N14_15290 ENOG4107R08 Integrase E8N14_15305 ENOG4107RCH Diaminopropionate ammonia-lyase E8N14_15320 ENOG4105C5S asparaginyl-tRNA synthetase E8N14_15325 ENOG4105FCK Membrane E8N14_15330 ENOG4105CGF Aromatic amino acid aminotransferase E8N14_15335 ENOG4105C5X domain protein E8N14_15340 ENOG4105EAQ (twin-arginine translocation) pathway signal E8N14_15345 ENOG4105DIT ErfK YbiS YcfS YnhG family protein E8N14_15360 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) E8N14_15370 ENOG4106371 Methyltransferase E8N14_15375 ENOG4107S90 membrAne E8N14_15380 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups E8N14_15400 ENOG4105T0Z Conserved Protein E8N14_15410 ENOG4105BZ1 (ABC) transporter E8N14_15415 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E8N14_15420 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E8N14_15425 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E8N14_15435 ENOG4108K0D peptidase, M48 E8N14_15450 ENOG4107VMU Membrane E8N14_15455 ENOG4105DDY UPF0142 protein ycaO E8N14_15460 ENOG4105TMB Formate nitrite transporter E8N14_15465 ENOG4105C6N Formate acetyltransferase E8N14_15470 ENOG4105GUS E8N14_15480 ENOG4105F1A Pyruvate formate-lyase E8N14_15485 ENOG4105E5D amino acid E8N14_15495 ENOG4107KGK dmso reductase anchor subunit E8N14_15500 ENOG4105QAX Iron-sulfur E8N14_15505 ENOG4107QY8 reductase E8N14_15515 ENOG4105D1H recombination factor protein RarA E8N14_15525 ENOG4105CNU cell division protein FtsK E8N14_15530 ENOG4105EW9 transcriptional regulator AsnC family E8N14_15535 ENOG4105C3M thioredoxin reductase E8N14_15540 ENOG4108JJ9 ABC, transporter E8N14_15545 ENOG4108JJ8 (ABC) transporter E8N14_15560 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) E8N14_15565 ENOG4105HEI LysR family (Transcriptional regulator E8N14_15570 ENOG4105EUB pirin domain protein E8N14_15575 ENOG4105CHJ isochorismatase hydrolase E8N14_15600 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E8N14_15610 ENOG4105VEQ Cold shock protein E8N14_15615 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E8N14_15620 ENOG4105DJY efflux transporter, rnd family, mfp subunit E8N14_15625 ENOG4108MJ5 VirK protein E8N14_15630 ENOG4105CPB ATP-dependent endonuclease of the OLD family E8N14_15635 ENOG4105DWU Membrane E8N14_15645 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E8N14_15650 ENOG4105C7K acetolactate synthase E8N14_15655 ENOG4105C5W Aldolase E8N14_15660 ENOG4105CGD Nad-dependent epimerase dehydratase E8N14_15665 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase E8N14_15670 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E8N14_15680 ENOG41064MM (LipO)protein E8N14_15685 ENOG4105E5Z arginine transporter ATP-binding subunit E8N14_15690 ENOG4106PMH Extracellular solute-binding protein family 3 E8N14_15695 ENOG4105GBT ABC transporter E8N14_15700 ENOG4105DMR ABC, transporter E8N14_15705 ENOG4106TNF Periplasmic binding protein E8N14_15730 ENOG4105RBQ inner membrane protein ybjO E8N14_15735 ENOG4105D38 putrescine abc transporter E8N14_15740 ENOG4105F38 ABC transporter, permease E8N14_15745 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E8N14_15750 ENOG4107RUE extracellular solute-binding protein family 1 E8N14_15755 ENOG4108RMJ sensory transduction regulator E8N14_15765 ENOG4108DBC nitroreductase E8N14_15770 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress E8N14_15775 ENOG41090BQ Glutaredoxin E8N14_15780 ENOG4105GWF inner membrane protein YbjM E8N14_15790 ENOG4108RFG Tetr family transcriptional regulator E8N14_15795 ENOG4106UW1 Major Facilitator superfamily E8N14_15800 ENOG4108HCJ Hydrolase E8N14_15805 ENOG4107QF7 multi-drug E8N14_15815 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E8N14_15820 ENOG4107FB0 transcriptional regulator DeoR family E8N14_15825 ENOG4105DZ1 carboxypeptidase E8N14_15830 ENOG4108TGY Glutathione S-transferase E8N14_15835 ENOG4105D8V Glucose sorbosone dehydrogenase E8N14_15845 ENOG4105CY2 Citrate transporter E8N14_15850 ENOG4108KB2 LysR family Transcriptional regulator E8N14_15855 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E8N14_15865 ENOG4105C1G acyl-Coa dehydrogenase E8N14_15875 ENOG4105C10 Electron transfer flavoprotein E8N14_15880 ENOG4105BZJ Electron transfer flavoprotein E8N14_15885 ENOG4105CI0 Citrate lyase E8N14_15890 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway E8N14_15905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E8N14_15910 ENOG4105DEF Extracellular solute-binding protein, family 5 E8N14_15915 ENOG4108JQ6 ABC transporter E8N14_15920 ENOG4105D44 asparaginase E8N14_15925 ENOG4105CVM Molybdenum cofactor synthesis domain protein E8N14_15930 ENOG4105D06 uba thif-type nad fad binding protein E8N14_15935 ENOG4105F1A Pyruvate formate-lyase E8N14_15945 ENOG4108HCJ Hydrolase E8N14_15950 ENOG41072TH Protein of unknown function (DUF1479) E8N14_15965 ENOG4105C5H ABC transporter E8N14_15970 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E8N14_15975 ENOG4105F4P )-transporter E8N14_15980 ENOG4105KST dependent repressor E8N14_15990 ENOG4108I6E Sulfatase E8N14_15995 ENOG4108T1M outer membrane protein x E8N14_16010 ENOG4107R0W ABC transporter E8N14_16015 ENOG4105E5Q amino acid AbC transporter E8N14_16020 ENOG4105CDA abc transporter atp-binding protein E8N14_16025 ENOG4105D8X mechanosensitive ion channel E8N14_16035 ENOG4105KSC Transcriptional regulator, TraR DksA family E8N14_16040 ENOG4105VR4 UPF0379 protein ybiJ E8N14_16045 ENOG4108MTB glycosyl transferase family E8N14_16050 ENOG4105DVT helicase E8N14_16055 ENOG4105C1J atp-dependent rna helicase E8N14_16060 ENOG4107MVR Transcriptional regulator E8N14_16070 ENOG4105CJ1 ABC, transporter E8N14_16075 ENOG4107QWP ABC-2 type transporter E8N14_16080 ENOG4107QWP ABC-2 type transporter E8N14_16085 ENOG4105I9U inner membrane protein ybhQ E8N14_16090 ENOG4105X23 Endonuclease Exonuclease phosphatase E8N14_16095 ENOG4105DZQ phospholipase D Transphosphatidylase E8N14_16100 ENOG4107UXM Membrane E8N14_16120 ENOG4105HFZ Membrane E8N14_16125 ENOG4108ZAF Molybdopterin E8N14_16130 ENOG4105M00 molybdopterin converting factor, subunit 1 E8N14_16140 ENOG4108RIR Molybdenum cofactor biosynthesis protein E8N14_16150 ENOG4105CHW UPF0052 protein E8N14_16175 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E8N14_16180 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E8N14_16195 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E8N14_16200 ENOG4108V1U phospholipid-binding protein E8N14_16230 ENOG4105NBR Pectinesterase E8N14_16240 ENOG4108K4B hydrolase E8N14_16250 ENOG4105E0C molybdate abc transporter E8N14_16255 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E8N14_16265 ENOG4105F4R Transcriptional regulator mode E8N14_16270 ENOG4105DKW ABC transporter E8N14_16280 ENOG4105CMR udp-glucose 4-epimerase E8N14_16285 ENOG4105F0Z galactose-1-phosphate uridylyltransferase E8N14_16295 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E8N14_16305 ENOG4105E0A ABC, transporter E8N14_16310 ENOG4105EHG Permease protein E8N14_16315 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E8N14_16320 ENOG4105D9Q decarboxylase (Beta subunit) E8N14_16325 ENOG4107QSA Oxaloacetate decarboxylase E8N14_16335 ENOG4107QWE )-transporter E8N14_16345 ENOG4105C5Q Transcriptional regulator E8N14_16355 ENOG4107GFK fumarate E8N14_16360 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E8N14_16365 ENOG4105JND homeobox protein E8N14_16370 ENOG4105PGM cation diffusion facilitator family transporter E8N14_16375 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E8N14_16415 ENOG4105UFD tol-pal system protein YbgF E8N14_16420 ENOG4105KCK Peptidoglycan-associated lipoprotein E8N14_16430 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA E8N14_16440 ENOG4105E02 MotA TolQ exbB proton channel E8N14_16445 ENOG4107YD3 Thioesterase E8N14_16450 ENOG4105KJB cyd operon protein YbgE E8N14_16460 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E8N14_16465 ENOG4105C4M (Ubiquinol oxidase) subunit I E8N14_16470 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E8N14_16480 ENOG4105C7S Dehydrogenase E8N14_16485 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E8N14_16490 ENOG4105E33 succinate dehydrogenase E8N14_16495 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E8N14_16500 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E8N14_16505 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E8N14_16510 ENOG4105BZN citrate synthase E8N14_16515 ENOG4108KK1 membrane protein AbrB duplication E8N14_16540 ENOG410602S Transferase E8N14_16580 ENOG4108W9T type 1 fimbriae regulatory protein E8N14_16595 ENOG4107R7A Allophanate hydrolase subunit 2 E8N14_16600 ENOG4105P4J Allophanate hydrolase, subunit 1 E8N14_16605 ENOG4107QNR UPF0135 protein E8N14_16615 ENOG4105CVP deoxyribo-dipyrimidine photolyase E8N14_16620 ENOG4105XIQ Protein of unknown function (DUF2517) E8N14_16630 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E8N14_16645 ENOG4105C08 Histidine kinase E8N14_16650 ENOG4105EEX Two component transcriptional regulator (Winged helix family E8N14_16660 ENOG4105CXN decarboxylase E8N14_16665 ENOG4105D5Q Arginine ornithine antiporter E8N14_16675 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 E8N14_16680 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) E8N14_16685 ENOG4105EV9 Alpha Beta Hydrolase E8N14_16690 ENOG4105NNH LexA regulated protein E8N14_16695 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) E8N14_16700 ENOG41090R7 Ferric uptake E8N14_16705 ENOG4106P55 Transcriptional regulator E8N14_16710 ENOG4107EFR Flavocytochrome c E8N14_16715 ENOG41079YP Citrate utilization protein b E8N14_16720 ENOG4105CSH Transporter E8N14_16725 ENOG4105GX6 (LipO)protein E8N14_16730 ENOG4105J5J Outer membrane porin E8N14_16740 ENOG4105CI1 PTS System E8N14_16750 ENOG4105CE4 GlcNAc 6-P deacetylase E8N14_16755 ENOG4105E2R ROK family E8N14_16760 ENOG4105D4U had-superfamily hydrolase, subfamily iia E8N14_16765 ENOG4105CAQ asparagine synthetase E8N14_16810 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E8N14_16820 ENOG4105C9A Phoh family E8N14_16830 ENOG4108JU5 Magnesium and cobalt efflux protein E8N14_16835 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E8N14_16840 ENOG4107RP9 extracellular solute-binding protein, family 3 E8N14_16845 ENOG4105EAD ABC transporter E8N14_16850 ENOG4105DRP amino acid AbC transporter E8N14_16855 ENOG4105CDA abc transporter atp-binding protein E8N14_16870 ENOG4105F7F Chaperone E8N14_16875 ENOG4105QFC Hsc56 co-chaperone of HscC E8N14_16880 ENOG41069CF Protein of unknown function (DUF1266) E8N14_16885 ENOG4105QFC Hsc56 co-chaperone of HscC E8N14_16890 ENOG41069CF Protein of unknown function (DUF1266) E8N14_16900 ENOG4107PAI alpha helical protein E8N14_16905 ENOG4108JUB Transcriptional regulator E8N14_16910 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E8N14_16935 ENOG4105DJF DNA polymerase III, delta' subunit E8N14_16940 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) E8N14_16945 ENOG4107QZB decarboxylase E8N14_16950 ENOG4108TGR phosphatase E8N14_16955 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E8N14_16960 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) E8N14_16965 ENOG4105CJN penicillin-binding protein E8N14_16970 ENOG4105CNI cell division protein FtsW E8N14_16975 ENOG4105K6T rare lipoprotein A E8N14_16980 ENOG4105DZ1 carboxypeptidase E8N14_16985 ENOG4108Z43 UPF0250 protein E8N14_16995 ENOG41064T2 transcriptional regulator, lysR family E8N14_17015 ENOG4107Z6W Protein CrcB homolog E8N14_17030 ENOG4105CEE C4-dicarboxylate transporter E8N14_17035 ENOG4106YYS transcriptional regulatory protein E8N14_17040 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E8N14_17045 ENOG4105DUA (citrate (pro-3S)-lyase ligase E8N14_17050 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) E8N14_17055 ENOG4105CI0 Citrate lyase E8N14_17060 ENOG4105CHY citrate lyase, alpha E8N14_17065 ENOG4105YGP holo-ACP synthase CitX E8N14_17070 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E8N14_17075 ENOG4107QPK )-transporter E8N14_17080 ENOG4105KTS ribonuclease E8N14_17085 ENOG4105NXH GreA GreB family elongation factor E8N14_17090 ENOG4105E2A Dehydrogenase E8N14_17095 ENOG4108U51 Universal stress protein E8N14_17105 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E8N14_17110 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) E8N14_17120 ENOG4108JU3 Alkyl hydroperoxide reductase E8N14_17125 ENOG4105D3R alkyl hydroperoxide reductase E8N14_17130 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase E8N14_17135 ENOG4105DQS Transcriptional regulator E8N14_17140 ENOG4105BZV Phosphoadenosine phosphosulfate reductase E8N14_17145 ENOG4105GTN ParB Domain Protein Nuclease E8N14_17150 ENOG4105CHM Aminotransferase E8N14_17155 ENOG4107SCQ Iron-containing alcohol dehydrogenase E8N14_17160 ENOG4105VCD cytoplasmic protein E8N14_17165 ENOG4105D22 carbon starvation protein E8N14_17175 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E8N14_17180 ENOG4105WQI isochorismatase E8N14_17185 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E8N14_17190 ENOG4105E4F Isochorismate synthase E8N14_17195 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein E8N14_17200 ENOG4105E8G Major facilitator Superfamily E8N14_17205 ENOG4105DQ5 transport system permease protein E8N14_17210 ENOG4105TVJ transport system, permease E8N14_17215 ENOG4105E0A ABC, transporter E8N14_17220 ENOG4108QY5 Ferric enterobactin transport protein E8N14_17225 ENOG4105C0W non-ribosomal peptide synthetase E8N14_17230 ENOG41085A6 mbth domain-containing protein E8N14_17235 ENOG4105E93 esterase E8N14_17240 ENOG4107RNH Outer membrane receptor FepA E8N14_17245 ENOG4108TSE Transferase E8N14_17255 ENOG4105WQ6 Membrane E8N14_17260 ENOG4105HFT AraC family transcriptional regulator E8N14_17265 ENOG41067SE Tetr family transcriptional regulator E8N14_17270 ENOG4105MSB protein, conserved in bacteria E8N14_17275 ENOG4108RCM Nitroreductase E8N14_17295 ENOG4105F3R pts system mannose fructose sorbose family iid E8N14_17305 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine E8N14_17310 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E8N14_17320 ENOG4105CUY Mechanosensitive ion channel E8N14_17325 ENOG4105C85 amino acid E8N14_17335 ENOG4108KBJ Inner membrane protein YkgB E8N14_17340 ENOG41066GK UPF0379 protein ykgI E8N14_17345 ENOG4107QN2 dihydrolipoyl dehydrogenase E8N14_17350 ENOG4108K01 transcriptional regulator E8N14_17355 ENOG4108IJF Heavy metal efflux pump, CzcA E8N14_17360 ENOG4105GR3 Histidine kinase E8N14_17370 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E8N14_17375 ENOG4105CKK Glycosyl transferase, family 2 E8N14_17500 ENOG4108N0N Phage Terminase Large Subunit E8N14_17535 ENOG4105KUS lysozyme E8N14_17610 ENOG4105CDU Replicative dna helicase E8N14_17730 ENOG4108KU3 Integrase E8N14_17745 ENOG4106KCD HTH_LUXR E8N14_17755 ENOG4106721 fimbriae Y protein E8N14_17760 ENOG4108Q9V regulatoR E8N14_17765 ENOG4108ZI2 Fimbrial protein E8N14_17770 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) E8N14_17775 ENOG4105CW0 outer membrane usher protein E8N14_17780 ENOG4108AF8 Chaperone E8N14_17790 ENOG4108WDE Fimbrial protein E8N14_17805 ENOG4105WQ3 Rna-binding protein E8N14_17810 ENOG4105S2T inner membrane protein YbcI E8N14_17830 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E8N14_17840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E8N14_17845 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E8N14_17850 ENOG4105C5B carbamate kinase E8N14_17855 ENOG4105G5A Protein of unknown function (DUF2877) E8N14_17860 ENOG4107REC cytoplasmic protein E8N14_17865 ENOG4107R1Q Membrane protein FdrA E8N14_17870 ENOG4105DG4 malate L-lactate dehydrogenase E8N14_17875 ENOG4105CE7 Amidase, hydantoinase carbamoylase family E8N14_17880 ENOG4105S0E allantoin catabolism protein E8N14_17885 ENOG4105BZW Glycerate kinase E8N14_17890 ENOG4105DTE Xanthine uracil vitamin C permease E8N14_17900 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E8N14_17910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E8N14_17915 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E8N14_17920 ENOG41060W2 glyoxylate carboligase E8N14_17945 ENOG4108UMI ABC transporter, permease E8N14_17950 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E8N14_17955 ENOG4105D01 (LipO)protein E8N14_17965 ENOG4105CV6 ABC transporter, permease E8N14_17970 ENOG4108I0Y (ABC) transporter E8N14_17975 ENOG4108UJV acyl-CoA thioesterase i E8N14_17980 ENOG4105E1F short-chain dehydrogenase reductase E8N14_17985 ENOG4107QR8 Thioredoxin E8N14_17990 ENOG4105C4B ABC transporter, permease E8N14_17995 ENOG41083J0 (ABC) transporter E8N14_18000 ENOG4107QX8 SPFH domain, Band 7 family protein E8N14_18005 ENOG4105G5H Membrane E8N14_18010 ENOG4108Z6Z Transcriptional regulator E8N14_18015 ENOG4105C59 p-type ATPase E8N14_18025 ENOG4105MBR gumn family E8N14_18030 ENOG4108Z66 YbaK ebsC protein E8N14_18035 ENOG4105CGH 5'-nucleotidase E8N14_18040 ENOG4105EU0 Major facilitator Superfamily E8N14_18045 ENOG4105CKD glutathione-regulated potassium-efflux system protein E8N14_18050 ENOG4107RE1 Inosine-guanosine kinase E8N14_18085 ENOG4107QMP dna polymerase iii subunits gamma and tau E8N14_18095 ENOG4105WD1 Membrane E8N14_18100 ENOG4108URS primosomal replication protein n'' E8N14_18105 ENOG4106428 Protein of unknown function (DUF2496) E8N14_18110 ENOG4105DNE Transposase E8N14_18115 ENOG4105EGS Mechanosensitive ion channel E8N14_18120 ENOG4107XI7 Tetr family transcriptional regulator E8N14_18125 ENOG4105C1P efflux transporter, rnd family, mfp subunit E8N14_18130 ENOG4105BZS acriflavin resistance protein E8N14_18135 ENOG4108UKR Biofilm formation regulator YbaJ E8N14_18145 ENOG4108UW5 maltose o-acetyltransferase E8N14_18150 ENOG4105GSJ Inner membrane protein ylaC E8N14_18165 ENOG41066DG (EAL) domain protein E8N14_18175 ENOG41080UX Methyltransferase E8N14_18180 ENOG4108MNP Glycoprotein polysaccharide metabolism E8N14_18185 ENOG4105C29 acyl-CoA thioesterase E8N14_18190 ENOG4105BZU Histidine kinase E8N14_18195 ENOG4108YZA Nitrogen regulatory protein pii E8N14_18200 ENOG4105BZ1 (ABC) transporter E8N14_18205 ENOG4105BZ1 (ABC) transporter E8N14_18210 ENOG4108XM1 transcriptional regulator AsnC family E8N14_18225 ENOG4108NFA extracellular solute-binding protein E8N14_18235 ENOG4108TGP Thioesterase superfamily protein E8N14_18240 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E8N14_18245 ENOG4105EIN peptidylprolyl cis-trans isomerase E8N14_18250 ENOG4105K70 DNA-binding protein E8N14_18255 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) E8N14_18280 ENOG4105M85 Bola protein E8N14_18285 ENOG4105IEY (LipO)protein E8N14_18290 ENOG4105EYM Major Facilitator superfamily E8N14_18295 ENOG4105E2S oxidase) subunit II E8N14_18300 ENOG4105BZ9 Cytochrome C oxidase, subunit I E8N14_18305 ENOG4105CCU oxidase (Subunit III) E8N14_18310 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E8N14_18330 ENOG4107RDB Major Facilitator E8N14_18340 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E8N14_18345 ENOG4107S0N DJ-1 family E8N14_18360 ENOG4106S9K Transcriptional regulator E8N14_18370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E8N14_18380 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component E8N14_18390 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E8N14_18395 ENOG4105CTB Polyprenyl synthetase E8N14_18405 ENOG4105CPC Aldo Keto reductase E8N14_18410 ENOG4108ZAI phosphatidylglycerophosphatase a E8N14_18415 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E8N14_18420 ENOG4107YIM Involved in the transcription termination process (By similarity) E8N14_18430 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E8N14_18440 ENOG4108KIC (LipO)protein E8N14_18445 ENOG4105DRB nucleoside-specific channel-forming protein E8N14_18460 ENOG4105N1F Hnh endonuclease E8N14_18475 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E8N14_18485 ENOG4105VIE preprotein translocase, subunit YajC E8N14_18505 ENOG4105D3R alkyl hydroperoxide reductase E8N14_18510 ENOG4107R28 alpha amylase, catalytic region E8N14_18515 ENOG4105C85 amino acid E8N14_18520 ENOG4105CWM branched-chain amino acid transport system II carrier protein E8N14_18525 ENOG4105BZU Histidine kinase E8N14_18530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E8N14_18535 ENOG4107RH8 nuclease SbcCD subunit D E8N14_18540 ENOG4105EYH Exonuclease E8N14_18545 ENOG4105F27 Major Facilitator E8N14_18550 ENOG4105DKQ ROK family E8N14_18565 ENOG4105HBA AroM protein E8N14_18570 ENOG4105SS3 E8N14_18585 ENOG4105II7 pyrroline-5-carboxylate reductase E8N14_18590 ENOG4105BZU Histidine kinase E8N14_18595 ENOG4105VIF phosphate starvation-inducible protein E8N14_18615 ENOG4105CPF Cell wall formation (By similarity) E8N14_18620 ENOG4105UNH Membrane E8N14_18625 ENOG4105FR5 inner membrane protein YaiY E8N14_18630 ENOG4107QS8 (LipO)protein E8N14_18635 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 E8N14_18645 ENOG4107R6D beta-lactam binding protein AmpH E8N14_18650 ENOG4108PNB DNA-binding transcriptional regulator E8N14_18655 ENOG4108NSE outer membrane autotransporter barrel E8N14_18660 ENOG4105D52 delta-aminolevulinic acid dehydratase E8N14_18665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E8N14_18670 ENOG4105DXD 2-methylcitrate dehydratase E8N14_18675 ENOG4105BZN citrate synthase E8N14_18680 ENOG4105CR4 methylisocitrate lyase E8N14_18685 ENOG4108JU7 Transcriptional regulator E8N14_18690 ENOG4105TDT uncharacterized protein yahO E8N14_18695 ENOG4105E82 cytochrome subunit of dehydrogenase E8N14_18715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E8N14_18720 ENOG4105C4M (Ubiquinol oxidase) subunit I E8N14_18730 ENOG4105D8D Type III E8N14_18735 ENOG4107QMH DNA methylase E8N14_18740 ENOG4105JHE Major Facilitator Superfamily E8N14_18770 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E8N14_18790 ENOG4108T1M outer membrane protein x E8N14_18805 ENOG4107XTP (EAL) domain protein E8N14_18820 ENOG4105X0I Fimbrial E8N14_18825 ENOG4108VEV chaperone E8N14_18830 ENOG4105CW0 outer membrane usher protein E8N14_18855 ENOG4105EJC lysr family transcriptional regulator E8N14_18865 ENOG4105ERH Fumarylacetoacetate hydrolase E8N14_18870 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E8N14_18875 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E8N14_18880 ENOG4105D94 Major Facilitator Superfamily E8N14_18885 ENOG4105V2F Uncharacterized protein yoac E8N14_18890 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E8N14_18895 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit E8N14_18925 ENOG4105FCK Membrane E8N14_18940 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) E8N14_18945 ENOG4105CIN aminoacyl-histidine dipeptidase E8N14_18950 ENOG4108S2Y peptide Chain Release factor E8N14_18965 ENOG4105F7V ErfK ybiS ycfS ynhG family protein E8N14_18970 ENOG4105E7A Glutamine amidotransferase E8N14_18980 ENOG4107QPN acyl-Coa dehydrogenase E8N14_18985 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase E8N14_18995 ENOG4105T40 surface antigen msp4 family protein E8N14_19015 ENOG4108XM1 transcriptional regulator AsnC family E8N14_19060 ENOG4105W7K Transcriptional regulator E8N14_19150 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E8N14_19165 ENOG4108P8R E8N14_19195 ENOG4105TS0 gtp-binding protein E8N14_19205 ENOG4108KZE transcriptional regulator E8N14_19240 ENOG4106H6R UPF0380 protein E8N14_19255 ENOG4106549 Antirestriction protein E8N14_19260 ENOG4108XS9 dna repair protein E8N14_19270 ENOG4105ZS6 Protein of unknown function (DUF987) E8N14_19280 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles E8N14_19315 ENOG4107RZZ dna polymerase iii epsilon subunit E8N14_19320 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E8N14_19325 ENOG4105D1A Methyltransferase E8N14_19335 ENOG4105E9H Lytic Murein transglycosylase E8N14_19340 ENOG4105F2W methyltransferase E8N14_19350 ENOG4105F27 Major Facilitator E8N14_19355 ENOG4105HEI LysR family (Transcriptional regulator E8N14_19360 ENOG4105CV8 reductase E8N14_19395 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E8N14_19405 ENOG4108UMI ABC transporter, permease E8N14_19410 ENOG4105D01 (LipO)protein E8N14_19415 ENOG4108R8X outer membrane lipoprotein E8N14_19420 ENOG4108R96 Methyltransferase, YaeB family E8N14_19430 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion E8N14_19435 ENOG4108YZN class I peptide chain release factor E8N14_19440 ENOG4108VWS Yaeq family E8N14_19450 ENOG4105M1T rho-binding antiterminator E8N14_19455 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E8N14_19460 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase E8N14_19465 ENOG4105CXN decarboxylase E8N14_19480 ENOG4105C0B DNA polymerase III (alpha subunit) E8N14_19500 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) E8N14_19505 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E8N14_19510 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) E8N14_19525 ENOG4105KNE Phosphatidate cytidylyltransferase E8N14_19540 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) E8N14_19545 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) E8N14_19555 ENOG4105CE9 30S ribosomal protein S2 E8N14_19560 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E8N14_19575 ENOG4105CSH Transporter E8N14_19585 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR E8N14_19590 ENOG4105C0H protease E8N14_19605 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E8N14_19610 ENOG4105EN6 Membrane E8N14_19615 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E8N14_19630 ENOG4106RDH Protein of unknown function (DUF2544) E8N14_19640 ENOG4105UGQ Fimbrial E8N14_19645 ENOG4105NEV Fimbrial E8N14_19650 ENOG4108FZ9 Chaperone E8N14_19655 ENOG4106PG1 outer membrane usher protein E8N14_19675 ENOG4105S6R Iron-hydroxamate transporter permease subunit E8N14_19680 ENOG4105J76 Periplasmic binding protein E8N14_19685 ENOG4105E0A ABC, transporter E8N14_19690 ENOG4105E0K tonB-dependent siderophore receptor E8N14_19695 ENOG4105BZ4 penicillin-binding protein E8N14_19700 ENOG4105CQ7 ATP-dependent helicase E8N14_19705 ENOG4107XID 2'-5' rna ligase E8N14_19715 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E8N14_19725 ENOG4105DJ0 Poly(A) Polymerase E8N14_19730 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E8N14_19750 ENOG4107BJW polysaccharide deacetylase E8N14_19755 ENOG4108YTN IIa component E8N14_19765 ENOG4108UIF Chaperone E8N14_19770 ENOG4105CW0 outer membrane usher protein E8N14_19775 ENOG4108MDY Fimbrial E8N14_19780 ENOG4105E3A (ABC) transporter E8N14_19785 ENOG4105DA5 (ABC) transporter E8N14_19790 ENOG41077A9 carbonic anhydrase E8N14_19795 ENOG4108UGV hypoxanthine phosphoribosyltransferase E8N14_19800 ENOG4105DZG Dehydrogenase E8N14_19805 ENOG4105E3B Multicopper oxidase E8N14_19810 ENOG4108ZRK uncharacterized protein yacC E8N14_19825 ENOG4105MVE transcriptional regulator E8N14_19830 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E8N14_19835 ENOG4107S2N Type III effector Hrp-dependent E8N14_19840 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) E8N14_19855 ENOG4106HGK Inner membrane protein yieI E8N14_19860 ENOG4107QIJ Aconitate hydratase 2 E8N14_19865 ENOG4108NST exported protein E8N14_19880 ENOG4107QN2 dihydrolipoyl dehydrogenase E8N14_19885 ENOG4107QSN dihydrolipoamide acetyltransferase E8N14_19890 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E8N14_19905 ENOG4105CT4 transporter E8N14_19910 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) E8N14_19915 ENOG4106A72 regulatory protein AmpE E8N14_19925 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E8N14_19935 ENOG4108ZUW Major pilin subunit E8N14_19940 ENOG4107QHF type ii secretion system protein e E8N14_19945 ENOG4105D7Q type ii secretion system E8N14_19955 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E8N14_19970 ENOG410642W LysR family Transcriptional regulator E8N14_19975 ENOG4108FN7 Aldo keto reductase E8N14_19980 ENOG4105M6F mutator MutT protein E8N14_19990 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) E8N14_20000 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E8N14_20005 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E8N14_20010 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E8N14_20015 ENOG4105CPF Cell wall formation (By similarity) E8N14_20030 ENOG4105CNI cell division protein FtsW E8N14_20040 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) E8N14_20045 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E8N14_20050 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E8N14_20055 ENOG4105CJN penicillin-binding protein E8N14_20060 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E8N14_20075 ENOG4107B7Y DNA-binding transcriptional regulator FruR E8N14_20080 ENOG4108ZP8 Acetolactate synthase small subunit E8N14_20085 ENOG4105C7K acetolactate synthase E8N14_20090 ENOG41064T2 transcriptional regulator, lysR family E8N14_20110 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E8N14_20115 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) E8N14_20140 ENOG4107T0D ABC, transporter E8N14_20145 ENOG4108KF1 Membrane E8N14_20150 ENOG41063TF transcriptional regulator (AraC E8N14_20165 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase E8N14_20175 ENOG4105D7V transposase E8N14_20200 ENOG4105CQ2 DNA polymerase E8N14_20210 ENOG4105D3G Pseudouridine synthase E8N14_20220 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E8N14_20230 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E8N14_20240 ENOG4105NWN ApaG protein E8N14_20280 ENOG4105M5B (LipO)protein E8N14_20285 ENOG4105C54 Major Facilitator superfamily E8N14_20290 ENOG4105WQV ferredoxin-like protein E8N14_20295 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E8N14_20340 ENOG4108XNW Transcriptional activatory protein CaiF E8N14_20345 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E8N14_20350 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E8N14_20375 ENOG4105CHY citrate lyase, alpha E8N14_20380 ENOG4105CI0 Citrate lyase E8N14_20390 ENOG4105DUA (citrate (pro-3S)-lyase ligase E8N14_20395 ENOG4105D2K citrate carrier protein E8N14_20400 ENOG4106AFN Lyase and sodium transporter (By similarity) E8N14_20405 ENOG4107QSA Oxaloacetate decarboxylase E8N14_20410 ENOG4105D9Q decarboxylase (Beta subunit) E8N14_20415 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E8N14_20420 ENOG4106YYS transcriptional regulatory protein E8N14_20440 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E8N14_20450 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E8N14_20455 ENOG4105DTN riboflavin biosynthesis protein ribF E8N14_20460 ENOG410647N response to DNA damage stimulus E8N14_20480 ENOG41063Z6 transcriptional regulator, lysR family E8N14_20500 ENOG4105C4X radical SAM domain protein E8N14_20505 ENOG41061MV Arylsulfatase E8N14_20515 ENOG4105CGH 5'-nucleotidase E8N14_20530 ENOG4105DQS Transcriptional regulator E8N14_20550 ENOG4106PH7 chaperone E8N14_20565 ENOG4105MHR Fimbrial protein E8N14_20570 ENOG4105CW0 outer membrane usher protein E8N14_20575 ENOG4108AF8 Chaperone E8N14_20635 ENOG4108QUJ UPF0174 protein YaaW E8N14_20640 ENOG4106HK8 GPR1 FUN34 yaaH family protein E8N14_20645 ENOG4108RIR Molybdenum cofactor biosynthesis protein E8N14_20650 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E8N14_20655 ENOG4105BZG amino acid carrier protein E8N14_20665 ENOG4105D98 threonine synthase E8N14_20675 ENOG4105CFH Aspartokinase E8N14_20685 ENOG4106FVC RNA methyltransferase E8N14_20690 ENOG410759A E8N14_20695 ENOG41065U4 response regulator E8N14_20705 ENOG4108PNB DNA-binding transcriptional regulator E8N14_20715 ENOG4108VCD Chaperone E8N14_20720 ENOG4105CW0 outer membrane usher protein E8N14_20735 ENOG4105CT7 inner membrane cred family protein E8N14_20740 ENOG4105EB3 Histidine kinase E8N14_20745 ENOG4105E3W Two component transcriptional regulator (Winged helix family E8N14_20750 ENOG4108RH0 Crea protein E8N14_20755 ENOG4105UEI Transcriptional Regulator AraC Family E8N14_20775 ENOG4107SC1 transglycosylase E8N14_20780 ENOG4105C5H ABC transporter E8N14_20785 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase E8N14_20790 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E8N14_20795 ENOG4105EAC phosphoserine phosphatase E8N14_20800 ENOG41062Z9 Membrane E8N14_20815 ENOG4105UMR response to DNA damage stimulus E8N14_20820 ENOG4108S1B Periplasmic chaperone protein E8N14_20825 ENOG4105E6S usher protein( E8N14_20855 ENOG4105G0K glycine radical enzyme YjjI family E8N14_20860 ENOG41076CZ activating enzyme E8N14_20865 ENOG4105EYA deoxyribonuclease E8N14_20870 ENOG4108NRW Phospholipase, patatin family E8N14_20880 ENOG4105K3G Periplasmic Protein E8N14_20890 ENOG4105PAD Hydrolase E8N14_20895 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E8N14_20900 ENOG4108WPU DNA polymerase III subunit psi E8N14_20925 ENOG4105YBH Protein of unknown function (DUF1435) E8N14_20930 ENOG4105BZU Histidine kinase E8N14_20935 ENOG4108819 ferric iron reductase E8N14_20940 ENOG4108UIN ybak prolyl-trna synthetase associated region E8N14_20945 ENOG4108T94 DNA-binding transcriptional activator BglJ E8N14_20950 ENOG4108N8T regulatoR E8N14_20955 ENOG4105DWK Membrane E8N14_20970 ENOG4106CVF DNA replication protein E8N14_20975 ENOG4105RI1 glycoprotein receptor E8N14_20985 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E8N14_20990 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E8N14_20995 ENOG4105F3R pts system mannose fructose sorbose family iid E8N14_21000 ENOG4105ETZ PTS System E8N14_21005 ENOG4108IQ3 PTS system E8N14_21025 ENOG4105C8Q Methyl-accepting chemotaxis E8N14_21030 ENOG4105D22 carbon starvation protein E8N14_21035 ENOG4105VCD cytoplasmic protein E8N14_21040 ENOG4105CKI cobalamin synthesis protein E8N14_21050 ENOG4108F3G Type I restriction-modification system, R subunit E8N14_21060 ENOG4107QTH restriction modification system DNA specificity domain E8N14_21075 ENOG4108HFV E8N14_21090 ENOG4105C26 Dehydrogenase E8N14_21095 ENOG4105DNE Transposase E8N14_21100 ENOG41083G8 Multidrug resistance protein MdtM E8N14_21105 ENOG4106BRA Membrane E8N14_21110 ENOG4105CBP Major Facilitator E8N14_21120 ENOG41074DU domain protein E8N14_21125 ENOG4108P2H Inner membrane protein YjiG E8N14_21130 ENOG4105DYB Isoaspartyl dipeptidase E8N14_21135 ENOG4107YNJ LysR family Transcriptional regulator E8N14_21155 ENOG4105C6F GntR Family Transcriptional Regulator E8N14_21175 ENOG4105KZM cytoplasmic protein E8N14_21185 ENOG4105DTA methyltransferase E8N14_21310 ENOG4105DQ4 alcohol dehydrogenase E8N14_21315 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E8N14_21320 ENOG4105CPQ Dehydrogenase E8N14_21325 ENOG4105CHR reductase E8N14_21330 ENOG4105C6Z Gluconate E8N14_21335 ENOG4105K2J Transcriptional regulator E8N14_21340 ENOG4108K5H permease YjgP YjgQ family protein E8N14_21345 ENOG4108M8S permease YjgP YjgQ family protein E8N14_21355 ENOG4105MYG DNA polymerase iii, chi subunit E8N14_21360 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E8N14_21365 ENOG4108M3P Membrane E8N14_21370 ENOG4108MJ3 acetyltransferase E8N14_21380 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E8N14_21385 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) E8N14_21390 ENOG4105DBV ornithine carbamoyltransferase E8N14_21395 ENOG4105XEP YhcH YjgK YiaL family protein E8N14_21400 ENOG4105CEU Arginine dihydrolase E8N14_21405 ENOG4105C5B carbamate kinase E8N14_21410 ENOG4105DBV ornithine carbamoyltransferase E8N14_21415 ENOG4105CSX c4-dicarboxylate anaerobic carrier E8N14_21420 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) E8N14_21430 ENOG41077AM PyrBI operon attenuator E8N14_21445 ENOG4105KME endoribonuclease L-psp E8N14_21460 ENOG4105D4X repressor E8N14_21465 ENOG4105C5Y PTS System E8N14_21470 ENOG4105CG3 alpha amylase, catalytic region E8N14_21475 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E8N14_21480 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E8N14_21485 ENOG4105K4U addiction module toxin, RelE StbE family E8N14_21495 ENOG4105EMD TRANSCRIPTIONal E8N14_21510 ENOG41069H0 dihydroorotase EC 3.5.2.3 E8N14_21540 ENOG4108XVM Cytochrome b(562) E8N14_21545 ENOG4105CMS peptidase U62, modulator of DNA gyrase E8N14_21555 ENOG4105DFU Cell wall formation (By similarity) E8N14_21565 ENOG4105F0N pyrophosphate phospho-hydrolase E8N14_21570 ENOG41069H0 dihydroorotase EC 3.5.2.3 E8N14_21575 ENOG4105DJB Major Facilitator Superfamily E8N14_21580 ENOG4108ZHD aig2 family E8N14_21600 ENOG4105C37 (CBS) domain E8N14_21605 ENOG41061GZ Protein of unknown function (DUF1107) E8N14_21610 ENOG4108UUE Transcriptional regulator E8N14_21615 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E8N14_21620 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E8N14_21625 ENOG4105KVH Transcriptional regulator E8N14_21630 ENOG4105ECR NmrA family E8N14_21635 ENOG4105DXC membrane E8N14_21660 ENOG4108V1T peptidylprolyl cis-trans isomerase E8N14_21665 ENOG4105FHY Opacity-associated protein A E8N14_21680 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) E8N14_21685 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) E8N14_21690 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) E8N14_21705 ENOG4105KIT UPF0379 protein yjfY E8N14_21735 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E8N14_21750 ENOG4108MXZ Esterase E8N14_21755 ENOG4105WSB biofilm stress and motility protein A E8N14_21760 ENOG4105S17 UPF0379 protein yjfN E8N14_21765 ENOG4105CSU acyl-Coa dehydrogenase E8N14_21770 ENOG4106032 Glutathionylspermidine synthase E8N14_21775 ENOG4108KXT Conserved Protein E8N14_21780 ENOG4105Z6B inner membrane protein yjfl E8N14_21785 ENOG4107VNS Protein of unknown function (DUF2491) E8N14_21800 ENOG4105FUX Conserved Protein E8N14_21805 ENOG4105C2N RNA methyltransferase TrmH family group 3 E8N14_21810 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E8N14_21830 ENOG4105EPW hflc protein E8N14_21835 ENOG4107QJR hflk protein E8N14_21840 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E8N14_21845 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E8N14_21860 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E8N14_21865 ENOG4105K8N protein family UPF0079, ATPase E8N14_21870 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E8N14_21875 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E8N14_21895 ENOG4106TNF Periplasmic binding protein E8N14_21900 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E8N14_21915 ENOG4105EGS Mechanosensitive ion channel E8N14_21920 ENOG4106CG8 Inner membrane protein YjeO E8N14_21925 ENOG4107SC7 Inner membrane transporter yjeM E8N14_21935 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) E8N14_21940 ENOG4105E33 succinate dehydrogenase E8N14_21950 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) E8N14_21960 ENOG4105KPY Small multidrug resistance protein E8N14_21970 ENOG4106BSU Entericidin B E8N14_21980 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) E8N14_21985 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E8N14_21990 ENOG4105MTB Uncharacterized protein YjeJ E8N14_21995 ENOG4108ZVF (LipO)protein E8N14_22010 ENOG4105DVH amino acid E8N14_22015 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 E8N14_22020 ENOG4108IJ0 Aspartate ammonia-lyase E8N14_22025 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E8N14_22035 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E8N14_22040 ENOG4108SIC Transcriptional regulator E8N14_22055 ENOG4105SBG acid phosphatase E8N14_22090 ENOG41068CG regulatoR E8N14_22095 ENOG4105D5T phosphonate abc transporter E8N14_22105 ENOG4108ZK4 sdia-regulated domain-containing protein E8N14_22115 ENOG4108NEM leader-binding protein dmsD E8N14_22120 ENOG4107KGK dmso reductase anchor subunit E8N14_22125 ENOG4105QAX Iron-sulfur E8N14_22130 ENOG4107QY8 reductase E8N14_22135 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism E8N14_22140 ENOG4108MRH transcriptional regulatory protein E8N14_22150 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter E8N14_22155 ENOG4107GFK fumarate E8N14_22160 ENOG4105CT4 transporter E8N14_22165 ENOG4105F8D glycoside hydrolase family 4 E8N14_22170 ENOG4108K2B transcriptional regulator E8N14_22175 ENOG4105CXN decarboxylase E8N14_22180 ENOG4106ZGR Transcriptional regulator E8N14_22185 ENOG4105D5Q Arginine ornithine antiporter E8N14_22190 ENOG4105DIJ Phosphoethanolamine transferase E8N14_22195 ENOG4105XJC Two component transcriptional regulator (Winged helix family E8N14_22200 ENOG4105ECM Sensor protein basS pmrB E8N14_22210 ENOG4105CSH Transporter E8N14_22215 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E8N14_22220 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase E8N14_22225 ENOG410870W N-acetyltransferase E8N14_22240 ENOG41082ND Uncharacterized protein yjcO E8N14_22245 ENOG4105CK2 sodium dicarboxylate symporter E8N14_22250 ENOG4108W0S formate-dependent nitrite reductase complex E8N14_22255 ENOG4108QKW cytochrome c-type biogenesis protein E8N14_22260 ENOG4105DVI reductase, NrfD E8N14_22265 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E8N14_22270 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit E8N14_22280 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E8N14_22285 ENOG41062QD Membrane E8N14_22295 ENOG41067MG lrgb family E8N14_22305 ENOG4105CMU LysR family (Transcriptional regulator E8N14_22310 ENOG4105EEQ Na H antiporter E8N14_22315 ENOG4105C7N Xanthine uracil vitamin C permease E8N14_22325 ENOG4108Z4X TRANSCRIPTIONal E8N14_22330 ENOG4108W3Q Transcriptional regulator E8N14_22335 ENOG4108M8H domain protein E8N14_22340 ENOG4105PMV Membrane E8N14_22380 ENOG4108UUM single-stranded DNA-binding protein E8N14_22385 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E8N14_22400 ENOG4105MSB protein, conserved in bacteria E8N14_22405 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme E8N14_22410 ENOG4105F0S class B acid phosphatase E8N14_22415 ENOG4105CGF Aromatic amino acid aminotransferase E8N14_22420 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E8N14_22425 ENOG4105CDU Replicative dna helicase E8N14_22430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E8N14_22435 ENOG4105P4Z Phage shock protein G E8N14_22440 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E8N14_22450 ENOG4105MYN Zinc uptake regulation protein E8N14_22455 ENOG4105VDW Csbd family E8N14_22465 ENOG4107R73 Mate efflux family protein E8N14_22470 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) E8N14_22475 ENOG41080IJ Diacylglycerol kinase E8N14_22495 ENOG4107W52 maltose operon periplasmic protein E8N14_22505 ENOG4108IJ9 (ABC) transporter E8N14_22515 ENOG4107FKK extracellular solute-binding protein family 1 E8N14_22520 ENOG4105D56 permease protein E8N14_22525 ENOG4105EG2 ABC transporter, permease E8N14_22535 ENOG4105E3R (LipO)protein E8N14_22540 ENOG4108Q9C Periplasmic Protein E8N14_22545 ENOG4108MDC (LipO)protein E8N14_22560 ENOG4105CFH Aspartokinase E8N14_22640 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) E8N14_22670 ENOG4108X9F tail fiber protein E8N14_22675 ENOG4105UZW Tail fiber assembly protein E8N14_22690 ENOG4108KP7 hydrolase E8N14_22695 ENOG4105E98 transcriptional regulator DeoR family E8N14_22700 ENOG4108ZR5 Conserved Protein E8N14_22705 ENOG4105FE9 pseudouridine synthase E8N14_22710 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E8N14_22725 ENOG4105EAM Na Pi-cotransporter E8N14_22730 ENOG4105C3R Methionine synthase E8N14_22735 ENOG41069M3 Transcriptional regulator E8N14_22750 ENOG4108I9X Isocitrate lyase E8N14_22755 ENOG4107QP3 malate synthase g E8N14_22765 ENOG4105K5X acetyltransferase E8N14_22795 ENOG4105C12 Phosphoribosylglycinamide synthetase E8N14_22800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E8N14_22805 ENOG4105BZU Histidine kinase E8N14_22815 ENOG4108T8B Protein of unknown function (DUF1481) E8N14_22820 ENOG4105K70 DNA-binding protein E8N14_22825 ENOG4105R2J Conserved Protein E8N14_22860 ENOG4105D06 uba thif-type nad fad binding protein E8N14_22865 ENOG4105WHD thiamine biosynthesis protein ThiS E8N14_22870 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) E8N14_22875 ENOG4105D41 biosynthesis protein thiH E8N14_22900 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E8N14_22905 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E8N14_22910 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) E8N14_22915 ENOG4108VZM 50s ribosomal protein L10 E8N14_22930 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E8N14_22935 ENOG4105PM1 preprotein translocase subunit SecE E8N14_22940 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) E8N14_22975 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase E8N14_22980 ENOG4105D4A Cell wall formation (By similarity) E8N14_23025 ENOG4108Y73 Membrane E8N14_23040 ENOG4105C5Q Transcriptional regulator E8N14_23075 ENOG4105DIJ Phosphoethanolamine transferase E8N14_23080 ENOG4106R3P AraC family transcriptional regulator E8N14_23085 ENOG4108XCZ PTS System E8N14_23090 ENOG4108AHH pyruvate formate lyase II activase E8N14_23100 ENOG4108YRF PTS System E8N14_23105 ENOG4105DM4 PTS System E8N14_23110 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E8N14_23120 ENOG4105DCT glycerol dehydrogenase E8N14_23125 ENOG4108XC3 NADH ubiquinone oxidoreductase E8N14_23135 ENOG4105SYT Methylenetetrahydrofolate reductase E8N14_23140 ENOG4105CGH 5'-nucleotidase E8N14_23155 ENOG4105D64 Mechanosensitive ion channel E8N14_23160 ENOG4105CFH Aspartokinase E8N14_23165 ENOG4105C28 cystathionine E8N14_23175 ENOG4108MR7 Arylsulfotransferase E8N14_23190 ENOG4105C25 Primosomal protein n' E8N14_23195 ENOG4105ETE Transcriptional regulator (LacI family E8N14_23200 ENOG41063M6 Cell Division Protein E8N14_23215 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E8N14_23230 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E8N14_23240 ENOG4105CBT Fructose-1,6-bisphosphatase E8N14_23245 ENOG4105DP0 ferredoxin-NADP reductase E8N14_23250 ENOG4108VTS Membrane E8N14_23255 ENOG4105EBK exported protein E8N14_23280 ENOG4105D4B ABC, transporter E8N14_23295 ENOG4105C2J ABC transporter E8N14_23305 ENOG4107RYS Autoinducer-2 (AI-2) kinase E8N14_23315 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) E8N14_23335 ENOG4105D7K pfkb domain protein E8N14_23340 ENOG4105CT4 transporter E8N14_23350 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E8N14_23355 ENOG4105CTQ phosphohexokinase E8N14_23365 ENOG4105FMW periplasmic E8N14_23370 ENOG4105E3W Two component transcriptional regulator (Winged helix family E8N14_23375 ENOG4105E0F Histidine kinase E8N14_23385 ENOG4108RPX mosc domain containing protein E8N14_23390 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E8N14_23395 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit E8N14_23400 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter E8N14_23405 ENOG4105CG6 trap dicarboxylate transporter dctm subunit E8N14_23410 ENOG4108QGT oligogalacturonate-specific porin E8N14_23430 ENOG4105DET Rhamnulokinase E8N14_23445 ENOG4105C0A alcohol dehydrogenase E8N14_23460 ENOG4108UMN azlc family E8N14_23470 ENOG4108V87 frv operon regulatory protein E8N14_23475 ENOG4108V87 frv operon regulatory protein E8N14_23490 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein E8N14_23495 ENOG4108MG3 formate dehydrogenase E8N14_23510 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system E8N14_23520 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) E8N14_23525 ENOG4108Z3N Transcriptional regulator E8N14_23530 ENOG4105SUU thioesterase domain E8N14_23545 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 E8N14_23550 ENOG4105E98 transcriptional regulator DeoR family E8N14_23555 ENOG4108MGF sugar kinase E8N14_23560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E8N14_23565 ENOG4105D2M Aldolase E8N14_23570 ENOG4107QKS N-acylglucosamine 2-epimerase E8N14_23575 ENOG4107WI4 Aldose-1-epimerase E8N14_23585 ENOG4105CJQ hydrolase, family 31 E8N14_23590 ENOG4105CT4 transporter E8N14_23595 ENOG4105CT4 transporter E8N14_23600 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is E8N14_23610 ENOG4105CI3 gtp-binding protein typa E8N14_23615 ENOG4105C5F glutamine synthetase E8N14_23620 ENOG4105CUX Signal transduction histidine kinase E8N14_23625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E8N14_23630 ENOG4106FIY E8N14_23635 ENOG4105D4P Coproporphyrinogen iii oxidase E8N14_23655 ENOG4105C2M dna polymerase I E8N14_23660 ENOG4106HNH Acyl-transferase E8N14_23665 ENOG4108Z33 Thiol disulfide Interchange Protein E8N14_23675 ENOG4105PC1 Conserved Protein E8N14_23680 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) E8N14_23685 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b E8N14_23715 ENOG4108RR8 protoporphyrinogen oxidase E8N14_23720 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) E8N14_23725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E8N14_23740 ENOG4105CHU acetyl-coa acetyltransferase E8N14_23745 ENOG4108MR7 Arylsulfotransferase E8N14_23750 ENOG4107QK7 reductase E8N14_23755 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) E8N14_23760 ENOG4105MDZ Transcriptional activator rfaH E8N14_23765 ENOG4105F8V Hydrolase, tatD family E8N14_23770 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E8N14_23775 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) E8N14_23780 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E8N14_23790 ENOG4105JC1 sterol-binding domain protein E8N14_23800 ENOG4105CGY Dna recombination protein E8N14_23805 ENOG4107SXA Phosphorylase E8N14_23810 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) E8N14_23815 ENOG4105C4X radical SAM domain protein E8N14_23825 ENOG4105DZ2 Transcriptional regulator E8N14_23830 ENOG4105EMK carboxylate amino acid amine transporter E8N14_23835 ENOG4105DQF Hydrolase E8N14_23840 ENOG4108EUD Lysophospholipase E8N14_23845 ENOG410829K Lysine exporter protein (Lyse ygga) E8N14_23850 ENOG4105CCF Lysine exporter protein (Lyse ygga) E8N14_23855 ENOG4105C9U ATP-dependent DNA helicase RecQ E8N14_23860 ENOG4105HDD phospholipase E8N14_23865 ENOG4108VUY thioesterase Superfamily protein E8N14_23870 ENOG4105FR1 rard protein E8N14_23885 ENOG4107QUT magnesium and cobalt transport protein CorA E8N14_23890 ENOG4105C4R Atp-dependent dna helicase E8N14_23895 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant E8N14_23900 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E8N14_23905 ENOG4105CT0 Protein of unknown function, DUF484 E8N14_23915 ENOG4105S7Z (LipO)protein E8N14_23935 ENOG4107T0K Adenylate cyclase E8N14_23945 ENOG41076E6 Uroporphyrinogen-III Synthase E8N14_23950 ENOG4105ECF c-methyltransferase E8N14_23955 ENOG410601J HemY protein E8N14_23980 ENOG4105C85 amino acid E8N14_24000 ENOG4105EGZ biosynthesis protein E8N14_24005 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E8N14_24010 ENOG4108WJ1 acetyltransferase E8N14_24015 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E8N14_24015 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) E8N14_24020 ENOG4105C1B dTDP-glucose 4-6-dehydratase E8N14_24025 ENOG4108IJ1 Dehydrogenase E8N14_24030 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E8N14_24035 ENOG4105SFE lipopolysaccharide biosynthesis protein E8N14_24040 ENOG4105ESV Glycosyl transferase, family 4 E8N14_24045 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E8N14_24070 ENOG4105C4R Atp-dependent dna helicase E8N14_24075 ENOG4106Z1T Nicotinamide Mononucleotide Transporter E8N14_24085 ENOG4105KQ5 peptidylprolyl cis-trans isomerase E8N14_24095 ENOG4105EMY transcriptional regulator E8N14_24110 ENOG4105C7B Threonine dehydratase E8N14_24120 ENOG4105CM2 brancheD-chain amino acid aminotransferase E8N14_24125 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit E8N14_24140 ENOG4105C0P Mg chelatase subunit ChlI E8N14_24185 ENOG4107EJG GntR family transcriptional regulator E8N14_24190 ENOG4105C0R drug resistance transporter emrb qaca subfamily E8N14_24195 ENOG4105ETE Transcriptional regulator (LacI family E8N14_24200 ENOG4108RVA ribokinase E8N14_24205 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator E8N14_24210 ENOG4105CNN ABC, transporter E8N14_24215 ENOG4105C2J ABC transporter E8N14_24245 ENOG4108VVK transcriptional Regulator, AsnC E8N14_24250 ENOG4105QTB Flavodoxin E8N14_24265 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation E8N14_24280 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E8N14_24300 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) E8N14_24305 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) E8N14_24320 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E8N14_24325 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) E8N14_24330 ENOG4105F9E Shikimate 5-dehydrogenase E8N14_24335 ENOG4105DM4 PTS System E8N14_24340 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) E8N14_24345 ENOG4105C8U phosphate abc transporter E8N14_24350 ENOG4105E2Z phosphate ABC transporter (Permease E8N14_24355 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E8N14_24365 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 E8N14_24370 ENOG4105C7N Xanthine uracil vitamin C permease E8N14_24375 ENOG4108YYH Nadph-dependent fmn reductase E8N14_24380 ENOG4105E8Q phosphopantetheinyl transferase E8N14_24400 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E8N14_24415 ENOG4105VG0 50S ribosomal protein l34