locus-tag class description ELZ77_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ELZ77_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ELZ77_00045 ENOG4105CXK mandelate racemase muconate lactonizing ELZ77_00050 ENOG4105DJB Major Facilitator Superfamily ELZ77_00055 ENOG410667J hydrolase ELZ77_00080 ENOG4108SV3 Tmao reductase system periplasmic protein tort ELZ77_00085 ENOG4106WF9 DNA-binding transcriptional regulator TorR ELZ77_00090 ENOG4105CUW cytochrome C-TYPE protein ELZ77_00095 ENOG4108EM1 reductase ELZ77_00105 ENOG4105CA0 peroxidase ELZ77_00120 ENOG4105X3C heme exporter protein ELZ77_00125 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ELZ77_00130 ENOG4105DA4 cytochrome c-type biogenesis protein ELZ77_00135 ENOG4107QX9 Thiol disulfide interChange protein ELZ77_00145 ENOG4105D99 atp gtp-binding protein ELZ77_00170 ENOG4105VG5 Membrane ELZ77_00175 ENOG4105JP4 Inner membrane protein yidG ELZ77_00180 ENOG4105J13 transcriptional regulator ELZ77_00195 ENOG4105W8I Transcriptional regulator ELZ77_00205 ENOG4105E5M Multidrug resistance protein D ELZ77_00230 ENOG4105C7K acetolactate synthase ELZ77_00235 ENOG4105M71 acetolactate synthase 1 regulatory subunit ELZ77_00240 ENOG4107FB0 transcriptional regulator DeoR family ELZ77_00245 ENOG4108RVA ribokinase ELZ77_00250 ENOG4105EDR glucose galactose transporter ELZ77_00260 ENOG4108KX4 response regulator ELZ77_00265 ENOG4105BZU Histidine kinase ELZ77_00270 ENOG4105CXY transporter ELZ77_00275 ENOG4105CXY transporter ELZ77_00280 ENOG4108SAJ Protein of unknown function (DUF1198) ELZ77_00285 ENOG4105FDP GntR family transcriptional regulator ELZ77_00295 ENOG41090UW PTS System ELZ77_00300 ENOG4105DT3 PTS system, galactitol-specific IIc component ELZ77_00310 ENOG4105D2N Aldolase ELZ77_00335 ENOG4105CS2 ec 3.2.1.21 ELZ77_00360 ENOG4105ETZ PTS System ELZ77_00365 ENOG4105F3R pts system mannose fructose sorbose family iid ELZ77_00380 ENOG4105DNE Transposase ELZ77_00385 ENOG4108UZ3 Transporter ELZ77_00395 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ELZ77_00410 ENOG4105CHJ isochorismatase hydrolase ELZ77_00420 ENOG4108TC1 Transcriptional regulator ELZ77_00425 ENOG4105FV3 ELZ77_00435 ENOG4105ISV protein with bipartite regulator domain ELZ77_00470 ENOG4105CT4 transporter ELZ77_00475 ENOG4105CJQ hydrolase, family 31 ELZ77_00480 ENOG4105JV1 AsmA family ELZ77_00485 ENOG4105C2W permease ELZ77_00495 ENOG4105CB5 ATP-dependent DNA helicase recG ELZ77_00500 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase ELZ77_00505 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ELZ77_00510 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ELZ77_00525 ENOG4105EN6 Membrane ELZ77_00545 ENOG4105DSJ YicC domain protein ELZ77_00570 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ELZ77_00585 ENOG4105W0E 50S ribosomal protein L33 ELZ77_00600 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ELZ77_00605 ENOG4105DKP glycosyl transferase, family 9 ELZ77_00610 ENOG4107RJ7 Glycosyl transferase (Group 1 ELZ77_00615 ENOG4107543 (lipo)polysaccharide ELZ77_00630 ENOG4107XU6 Glycosyl transferase (Group 1 ELZ77_00635 ENOG4106AH0 Glycosyl Transferase ELZ77_00640 ENOG4105X1N Glycosyl transferase family 8 ELZ77_00645 ENOG4108PDR lipopolysaccharide core biosynthesis protein ELZ77_00650 ENOG4108QD8 lipopolysaccharide core biosynthesis protein ELZ77_00655 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase ELZ77_00660 ENOG4108FRV O-antigen ligase ELZ77_00665 ENOG4105D16 lipopolysaccharide heptosyltransferase i ELZ77_00670 ENOG4105XA0 heptosyltransferase ii ELZ77_00680 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ELZ77_00690 ENOG4105K64 Glycosyl transferase, family 2 ELZ77_00695 ENOG4105PXI polysaccharide deacetylase ELZ77_00700 ENOG41063SB peptidase ELZ77_00710 ENOG4107YZP Rhodanese domain protein ELZ77_00715 ENOG4105VW4 glutaredoxin 3 ELZ77_00730 ENOG4105D7W serine acetyltransferase ELZ77_00735 ENOG4105DJB Major Facilitator Superfamily ELZ77_00740 ENOG4105DIA mandelate racemase muconate lactonizing ELZ77_00745 ENOG4105ETE Transcriptional regulator (LacI family ELZ77_00750 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ELZ77_00760 ENOG41073TP transcriptional regulator ELZ77_00765 ENOG4105DAA L-lactate ELZ77_00770 ENOG4105EUR Domain-Containing protein ELZ77_00775 ENOG4108WY4 inner membrane lipoprotein ELZ77_00785 ENOG4108YYI Protein of unknown function (DUF2810) ELZ77_00790 ENOG41060ND LF82 chromosome, complete sequence ELZ77_00795 ENOG4105E61 Mannitol repressor protein ELZ77_00805 ENOG4105CTS PTS system mannitol-specific ELZ77_00810 ENOG4108U78 Glutathione S-transferase ELZ77_00820 ENOG4105EM7 Selenocysteine-specific translation elongation factor ELZ77_00825 ENOG41066F8 ROK family ELZ77_00830 ENOG4105C26 Dehydrogenase ELZ77_00850 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ELZ77_00855 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase ELZ77_00860 ENOG4105H6Q decarboxylase ELZ77_00870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ELZ77_00875 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ELZ77_00880 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter ELZ77_00885 ENOG4108M5W ELZ77_00890 ENOG4108R66 Conserved Protein ELZ77_00900 ENOG4105J4Q Transcriptional regulator ELZ77_00905 ENOG4108XIB electron transport protein ysaA ELZ77_00910 ENOG4105JKW Valine--pyruvate aminotransferase ELZ77_00920 ENOG4108UR8 BAX protein ELZ77_00925 ENOG4105T16 Transcriptional regulator (AraC family) ELZ77_00935 ENOG4105C93 Xylose Isomerase ELZ77_00940 ENOG4105CMG Carbohydrate kinase ELZ77_00945 ENOG410688U Inner membrane protein yiaB ELZ77_00950 ENOG4105MEV Acyl-transferase ELZ77_00975 ENOG4105DQ6 Transposase ELZ77_01000 ENOG4105VEQ Cold shock protein ELZ77_01005 ENOG4105MVF Transcriptional regulator ELZ77_01010 ENOG4106JH6 (LipO)protein ELZ77_01020 ENOG4108ZG0 Ompa motb domain protein ELZ77_01025 ENOG4107QY8 reductase ELZ77_01030 ENOG4105HNP -acetyltransferase ELZ77_01035 ENOG4108R3E Dna-3-methyladenine glycosylase i ELZ77_01040 ENOG4105EAX Putative lipase ELZ77_01045 ENOG4106EAR Fimbrial protein ELZ77_01050 ENOG4108VCD Chaperone ELZ77_01060 ENOG4105CW0 outer membrane usher protein ELZ77_01070 ENOG4106UCC Fimbrial protein ELZ77_01075 ENOG4105DIJ Phosphoethanolamine transferase ELZ77_01090 ENOG4105CQ4 Transcriptional regulator ELZ77_01105 ENOG4105DEF Extracellular solute-binding protein, family 5 ELZ77_01115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ELZ77_01125 ENOG4105C3U ABC transporter ELZ77_01130 ENOG4108JQ7 (ABC) transporter ELZ77_01135 ENOG4105C44 Serine transporter ELZ77_01150 ENOG4105D1V cellulose synthase operon protein YhjU ELZ77_01155 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT ELZ77_01165 ENOG410661M cytoplasmic protein ELZ77_01170 ENOG4105UTS cellulose synthase operon protein YhjQ ELZ77_01175 ENOG4107QZ7 Cellulose synthase catalytic subunit ELZ77_01180 ENOG4107EEX Cellulose synthase regulator protein ELZ77_01185 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) ELZ77_01190 ENOG4105EJG cellulose synthase ELZ77_01200 ENOG4105BZU Histidine kinase ELZ77_01210 ENOG4105CS0 peptidase ELZ77_01215 ENOG4107SS6 2-dehydro-3-deoxygluconokinase ELZ77_01220 ENOG4105CMB EAL domain-containing protein ELZ77_01225 ENOG41066T0 asmA family ELZ77_01230 ENOG4105CSH Transporter ELZ77_01235 ENOG4107H3J ribonuclease ELZ77_01240 ENOG4105CBN LysR family transcriptional regulator ELZ77_01250 ENOG4106S2D Transcriptional regulator ELZ77_01270 ENOG4105FDP GntR family transcriptional regulator ELZ77_01275 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine ELZ77_01280 ENOG4108KPW sugar kinase ELZ77_01285 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ELZ77_01295 ENOG4105DC8 reductase ELZ77_01300 ENOG4105D6S protein involved in catabolism of external DNA ELZ77_01305 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ELZ77_01310 ENOG4105DGW oligopeptidase A ELZ77_01320 ENOG4105DUX Transporter ELZ77_01325 ENOG4108M6U Universal stress protein A ELZ77_01335 ENOG4105CJ3 phosphate transporter ELZ77_01340 ENOG4105CBX hi0933 family ELZ77_01345 ENOG4105D0S secretion protein (HlyD ELZ77_01350 ENOG4105CJ1 ABC, transporter ELZ77_01365 ENOG4107YAK holo-(acyl carrier protein) synthase 2 ELZ77_01370 ENOG4105DSF transport protein ELZ77_01380 ENOG4108W1V Lipoprotein ELZ77_01385 ENOG4105EX9 Membrane ELZ77_01395 ENOG4105C8Q Methyl-accepting chemotaxis ELZ77_01405 ENOG4107FS9 Membrane ELZ77_01415 ENOG4105MG3 Membrane ELZ77_01420 ENOG4106H78 methyltransferase ELZ77_01425 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ELZ77_01435 ENOG4105CRP Part of the ABC transporter FtsEX involved in ELZ77_01445 ENOG4105CP9 extracellular ligand-binding receptor ELZ77_01455 ENOG4105U59 -acetyltransferase ELZ77_01460 ENOG4105CP9 extracellular ligand-binding receptor ELZ77_01465 ENOG4105C32 Amino acid ABC transporter (Permease) ELZ77_01475 ENOG4105C0Z ABC transporter ELZ77_01480 ENOG4108IV0 ABC, transporter ELZ77_01490 ENOG4105BZ7 extracellular solute-binding protein family 1 ELZ77_01505 ENOG4108IJ9 (ABC) transporter ELZ77_01510 ENOG4107T6V glycerophosphoryl diester phosphodiesterase ELZ77_01515 ENOG4105WC8 Conserved Protein ELZ77_01520 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ELZ77_01525 ENOG41080QX K07048 phosphotriesterase-related protein ELZ77_01540 ENOG4108RVA ribokinase ELZ77_01545 ENOG4105WCN acetyltransferase ELZ77_01550 ENOG4105D9R oxidoreductase ELZ77_01555 ENOG4105C2I pirin domain protein ELZ77_01565 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ELZ77_01570 ENOG4105C6Z Gluconate ELZ77_01575 ENOG41076UM multiple antibiotic resistance (MarC)-related protein ELZ77_01580 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ELZ77_01585 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ELZ77_01605 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ELZ77_01610 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ELZ77_01625 ENOG4105E98 transcriptional regulator DeoR family ELZ77_01635 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ELZ77_01640 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ELZ77_01645 ENOG4105C6Z Gluconate ELZ77_01655 ENOG4105MJ2 Competence protein ELZ77_01665 ENOG4105DNE Transposase ELZ77_01680 ENOG4105XFK Ferrous iron transport protein A ELZ77_01685 ENOG4105BZM domain protein ELZ77_01690 ENOG4108RRZ Transcription elongation factor GreB ELZ77_01710 ENOG4108MAJ Membrane ELZ77_01715 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ELZ77_01720 ENOG4105VEJ Heat shock protein ELZ77_01725 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 ELZ77_01730 ENOG4105DQY intracellular growth attenuator ELZ77_01735 ENOG4107RK2 ADP-ribose diphosphatase NudE ELZ77_01740 ENOG4108JQC penicillin-binding protein 1A ELZ77_01745 ENOG4108U1Q Pilus assembly protein ELZ77_01750 ENOG41065NF Fimbrial assembly family protein ELZ77_01755 ENOG4105XPX DNA utilization protein HofO ELZ77_01760 ENOG4105ITY Required for the use of extracellular DNA as a nutrient ELZ77_01765 ENOG4105E4G Type IV pilus ELZ77_01785 ENOG4105EGB membrane protein DamX ELZ77_01790 ENOG4105DFE Dna adenine methylase ELZ77_01795 ENOG4105DJV ribulose-phosphate 3-epimerase ELZ77_01805 ENOG4105C31 Tryptophanyl-tRNA synthetase ELZ77_01810 ENOG4105VYH ELZ77_01820 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ELZ77_01825 ENOG4107V9H nitrite transporter ELZ77_01830 ENOG4105WZK nitrite reductase NADPH small subunit ELZ77_01835 ENOG4107QZF nitrite reductase NADPH large subunit ELZ77_01845 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ELZ77_01850 ENOG4106195 uncharacterized protein yhfG ELZ77_01855 ENOG4105MZU cell filamentation protein ELZ77_01860 ENOG4105DDQ anthranilate synthase ELZ77_01865 ENOG4105C8Y Acetylornithine aminotransferase ELZ77_01870 ENOG410613R integral membrane protein, YccS YhfK family ELZ77_01880 ENOG4108UKZ OsmC family ELZ77_01885 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ELZ77_01895 ENOG4105DNZ Alpha Beta Hydrolase ELZ77_01905 ENOG4105N0V mono-oxygenase ydhR ELZ77_01915 ENOG4105C5H ABC transporter ELZ77_01930 ENOG4105VKU nucleicacid-binding protein ELZ77_01935 ENOG4108YZY peptidylprolyl cis-trans isomerase ELZ77_01945 ENOG4108V1T peptidylprolyl cis-trans isomerase ELZ77_01950 ENOG4105WWK YheO domain protein ELZ77_01960 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ELZ77_01965 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ELZ77_01975 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ELZ77_01985 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ELZ77_01990 ENOG4105W53 bacterioferritin-associated ferredoxin ELZ77_01995 ENOG4108UQY Iron-storage protein ELZ77_02000 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ELZ77_02015 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ELZ77_02030 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ELZ77_02040 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ELZ77_02050 ENOG41083MP 50s ribosomal protein l29 ELZ77_02060 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ELZ77_02065 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ELZ77_02080 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ELZ77_02090 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ELZ77_02095 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ELZ77_02100 ENOG4105VPB 50S ribosomal protein L30 ELZ77_02105 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ELZ77_02110 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ELZ77_02115 ENOG41067V7 50S ribosomal protein L36 ELZ77_02135 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ELZ77_02145 ENOG4105VTS DnaJ-like, subfamily C ELZ77_02150 ENOG4105W1Y Transcriptional regulator ELZ77_02155 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system ELZ77_02165 ENOG4105C1A potassium transporter peripheral membrane ELZ77_02185 ENOG4105C79 DNA protecting protein DprA ELZ77_02195 ENOG4108WI1 Dna topoisomerase ELZ77_02210 ENOG4105SG3 Protein of unknown function (DUF1488) ELZ77_02215 ENOG4108Z0R Transferase ELZ77_02245 ENOG4105XCM membrane LIPOPROTEIN ELZ77_02250 ENOG4105BZS acriflavin resistance protein ELZ77_02255 ENOG4105C1P efflux transporter, rnd family, mfp subunit ELZ77_02260 ENOG4108XG4 DNA-binding transcriptional regulator ELZ77_02265 ENOG4105BZU Histidine kinase ELZ77_02270 ENOG41061ME transport protein ELZ77_02275 ENOG4105CEC DNA methylase N-4 N-6 ELZ77_02280 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ELZ77_02285 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ELZ77_02305 ENOG4105RG0 Membrane ELZ77_02310 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ELZ77_02315 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ELZ77_02330 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ELZ77_02335 ENOG41062P1 Diguanylate cyclase phosphodiesterase ELZ77_02345 ENOG4105DFF Rod shape-determining protein mreb ELZ77_02350 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ELZ77_02355 ENOG4105VQ7 Rod shape-determining protein MreD ELZ77_02365 ENOG4105C03 ribonuclease ELZ77_02370 ENOG4105QD6 exported protein ELZ77_02375 ENOG4105D1U peptidase U62 modulator of DNA gyrase ELZ77_02380 ENOG4105CR8 Transcriptional regulator ELZ77_02385 ENOG4105ZQC membrane protein AaeX ELZ77_02400 ENOG4105UNR (Barnase) inhibitor ELZ77_02405 ENOG4105RID UPF0379 protein yhcN ELZ77_02410 ENOG4105RID UPF0379 protein yhcN ELZ77_02425 ENOG4105FDP GntR family transcriptional regulator ELZ77_02435 ENOG4105C8P )-transporter ELZ77_02440 ENOG4106DSS Tartrate dehydratase subunit alpha ELZ77_02445 ENOG4107GFK fumarate ELZ77_02455 ENOG4107QSA Oxaloacetate decarboxylase ELZ77_02460 ENOG4105D9Q decarboxylase (Beta subunit) ELZ77_02475 ENOG4105C0H protease ELZ77_02480 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III ELZ77_02485 ENOG4105D6Z AFG1 family ATPase ELZ77_02500 ENOG4107MKT Stringent starvation protein a ELZ77_02505 ENOG4105KB2 stringent starvation protein b ELZ77_02535 ENOG4108R66 Conserved Protein ELZ77_02540 ENOG4105DZC cytosine deaminase ELZ77_02545 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin ELZ77_02550 ENOG4105DFS Conserved Protein ELZ77_02555 ENOG4105BZ8 glutamate synthase ELZ77_02565 ENOG4105N5T Radical SAM Protein ELZ77_02570 ENOG4105BZU Histidine kinase ELZ77_02575 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ELZ77_02585 ENOG4108NIH transferase activity, transferring phosphorus-containing groups ELZ77_02595 ENOG41080Z8 PHOSPHOCARRIER protein ELZ77_02605 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ELZ77_02610 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ELZ77_02615 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ELZ77_02620 ENOG4108IUZ ABC transporter ELZ77_02625 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ELZ77_02630 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) ELZ77_02635 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ELZ77_02640 ENOG4105C2X Arabinose 5-phosphate isomerase ELZ77_02645 ENOG4105FEU K -dependent Na -Ca exchanger ELZ77_02650 ENOG4105DHJ ABC, transporter ELZ77_02655 ENOG4105CY3 ABC transporter, permease ELZ77_02660 ENOG4107PE3 Mammalian cell entry related domain protein ELZ77_02665 ENOG4105E3I toluene tolerance ELZ77_02670 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane ELZ77_02675 ENOG4105VFK BolA family ELZ77_02685 ENOG4105HVQ Regulatory factor of maltose metabolism ELZ77_02690 ENOG4105EAH synthase ELZ77_02705 ENOG4105QYV Membrane ELZ77_02715 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ELZ77_02720 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ELZ77_02725 ENOG4105HBR Rna-binding protein ELZ77_02730 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ELZ77_02735 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ELZ77_02740 ENOG4105EEI dihydropteroate synthase ELZ77_02760 ENOG4105CDH Citrulline--aspartate ligase ELZ77_02775 ENOG4105CHV Transcription elongation factor NusA ELZ77_02815 ENOG4105C1J atp-dependent rna helicase ELZ77_02820 ENOG4105CIC tryptophan-specific transport protein ELZ77_02825 ENOG4105DEN Luciferase family ELZ77_02830 ENOG4106RZ4 Peptidase U32 ELZ77_02835 ENOG4105CFP Peptidase U32 ELZ77_02840 ENOG4105XPQ lipid carrier protein ELZ77_02845 ENOG4108YYD acetyltransferase ELZ77_02860 ENOG4107R7Y intracellular protease Pfpi family ELZ77_02865 ENOG4105K4T epimerase ELZ77_02870 ENOG4105W4M Transport-associated protein ELZ77_02885 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ELZ77_02890 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ELZ77_02900 ENOG4107WTH Galactitol-1-phosphate dehydrogenase ELZ77_02905 ENOG4105DT3 PTS system, galactitol-specific IIc component ELZ77_02910 ENOG41090UW PTS System ELZ77_02915 ENOG41082GB PTS system galactitol-specific transporter subunit IIA ELZ77_02930 ENOG4105CTX dehydratase ELZ77_02940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ELZ77_02945 ENOG4105BZW Glycerate kinase ELZ77_02960 ENOG410811B TRANSCRIPTIONal ELZ77_02965 ENOG4105C7B Threonine dehydratase ELZ77_02980 ENOG4105C6N Formate acetyltransferase ELZ77_02985 ENOG4105EJQ L-serine dehydratase ELZ77_02990 ENOG4105C44 Serine transporter ELZ77_03000 ENOG4106D80 Uncharacterized protein YhaL ELZ77_03005 ENOG4108CNN domain protein ELZ77_03010 ENOG4105CWB LysR family transcriptional Regulator ELZ77_03015 ENOG4105KAF membrAne ELZ77_03020 ENOG4105CHF Glutathione S-transferase ELZ77_03025 ENOG4108VBZ doxx family ELZ77_03030 ENOG4105YJD ELZ77_03035 ENOG41090KG Inner membrane protein YqjE ELZ77_03040 ENOG4105NE1 Conserved Protein ELZ77_03045 ENOG4105WAY exported protein ELZ77_03055 ENOG4106W5V Membrane ELZ77_03065 ENOG4105DU1 integral membrane protein, terc ELZ77_03070 ENOG4105EE0 oxidoreductase ELZ77_03075 ENOG4108UB4 uncharacterized protein ygjQ ELZ77_03080 ENOG4108VKG metal-dependent hydrolase ELZ77_03090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ELZ77_03100 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ELZ77_03105 ENOG4105C8Q Methyl-accepting chemotaxis ELZ77_03110 ENOG4105NTW Transcriptional regulator ELZ77_03115 ENOG4105Q26 Siderophore-interacting protein ELZ77_03130 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ELZ77_03135 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ELZ77_03140 ENOG4105VCC 30S ribosomal protein S21 ELZ77_03150 ENOG4106DSS Tartrate dehydratase subunit alpha ELZ77_03160 ENOG4107ZVW dihydroneopterin aldolase ELZ77_03175 ENOG4106MWK domain protein ELZ77_03180 ENOG4105I7R Adenylate cyclase ELZ77_03200 ENOG4107S78 Band 7 protein ELZ77_03205 ENOG4105PV3 Inner membrane protein yqiJ ELZ77_03215 ENOG4105W0Z cytoplasmic protein ELZ77_03235 ENOG4108MR7 Arylsulfotransferase ELZ77_03245 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ELZ77_03250 ENOG4106032 Glutathionylspermidine synthase ELZ77_03265 ENOG41087AY ADP-Ribose pyrophosphatase ELZ77_03270 ENOG4108SX3 cytoplasmic protein ELZ77_03275 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ELZ77_03280 ENOG4105IPS esterase ELZ77_03285 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ELZ77_03290 ENOG4105VRH Antibiotic biosynthesis monooxygenase ELZ77_03295 ENOG4105NF4 modulator of drug activity ELZ77_03300 ENOG4105DHQ Histidine kinase ELZ77_03305 ENOG4105XJC Two component transcriptional regulator (Winged helix family ELZ77_03310 ENOG4105H4F exported protein ELZ77_03315 ENOG4105F4I Transcriptional regulator ELZ77_03320 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ELZ77_03325 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ELZ77_03330 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) ELZ77_03375 ENOG4107QPK )-transporter ELZ77_03380 ENOG4105CV8 reductase ELZ77_03385 ENOG4108I6A alcohol dehydrogenase ELZ77_03390 ENOG4105CF7 AraC family transcriptional regulator ELZ77_03395 ENOG4108K81 inner membrane protein YghB ELZ77_03400 ENOG4105C28 cystathionine ELZ77_03405 ENOG4105CWK Biopolymer transport protein, ExbB ELZ77_03410 ENOG4108ZZF transport protein (ExbD) ELZ77_03415 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ELZ77_03445 ENOG410900S Protein of unknown function (DUF2623) ELZ77_03450 ENOG4105E3S small subunit ELZ77_03455 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ELZ77_03460 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit ELZ77_03465 ENOG4105DPX Hydrogenase, large subunit ELZ77_03475 ENOG4108WGS hydrogenase 2-specific chaperone ELZ77_03480 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ELZ77_03485 ENOG41082MF Hydrogenase assembly chaperone hypC hupF ELZ77_03490 ENOG4105S10 periplasmic binding protein ELZ77_03495 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein ELZ77_03500 ENOG4105CYM Glutathione S-transferase ELZ77_03525 ENOG4105DEI Mannitol dehydrogenase ELZ77_03535 ENOG4105DPW Major facilitator superfamily MFS_1 ELZ77_03560 ENOG4105C26 Dehydrogenase ELZ77_03565 ENOG4105CJP fad dependent oxidoreductase ELZ77_03575 ENOG4105CUB amino acid ELZ77_03585 ENOG4108UAJ Transcriptional regulator ELZ77_03715 ENOG4105E3J oxidoreductase ELZ77_03720 ENOG41066GK UPF0379 protein ykgI ELZ77_03725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ELZ77_03740 ENOG4108UQV Membrane ELZ77_03745 ENOG4105CXN decarboxylase ELZ77_03750 ENOG4105EAA nucleoside ELZ77_03765 ENOG4105CEN a g-specific adenine glycosylase ELZ77_03775 ENOG41090ED Protein with unknown function (DUF469) ELZ77_03780 ENOG4105K33 Periplasmic Protein ELZ77_03785 ENOG4105HDK L-asparaginase ELZ77_03790 ENOG4106MH3 alpha helix chain ELZ77_03795 ENOG4105CSA Coproporphyrinogen iii oxidase ELZ77_03810 ENOG4108VIA integral membrane protein ELZ77_03815 ENOG4105DFA alanine racemase domain protein ELZ77_03820 ENOG4105CZX twitching motility protein ELZ77_03840 ENOG4105D7Z glutathione synthase ELZ77_03845 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ELZ77_03850 ENOG4105RWS endonuclease I ELZ77_03860 ENOG4107QNK )-transporter ELZ77_03885 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ELZ77_03895 ENOG4108K0D peptidase, M48 ELZ77_03900 ENOG4105CV1 Transketolase (EC 2.2.1.1) ELZ77_03905 ENOG4108JJB ABC transporter ELZ77_03910 ENOG4108JJB ABC transporter ELZ77_03945 ENOG4105D2N Aldolase ELZ77_03950 ENOG4105D64 Mechanosensitive ion channel ELZ77_03960 ENOG4105MPN Membrane ELZ77_03980 ENOG4108JQ1 Dehydrogenase ELZ77_03985 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ELZ77_04005 ENOG4107RAQ aminopeptidase ELZ77_04010 ENOG4105D0A hydroxylase ELZ77_04015 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ELZ77_04045 ENOG4105CS2 ec 3.2.1.21 ELZ77_04055 ENOG4108UT2 hemolysin iii ELZ77_04075 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB ELZ77_04080 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ELZ77_04085 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ELZ77_04090 ENOG4105T95 Thiol disulfide interChange protein ELZ77_04095 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ELZ77_04105 ENOG4105CRK lysyL-tRNA synthetase ELZ77_04120 ENOG4108K5P (LipO)protein ELZ77_04135 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A ELZ77_04145 ENOG4108T1M outer membrane protein x ELZ77_04165 ENOG4106P2F Pfam:Pili_assembly_C ELZ77_04195 ENOG4108MHD transport protein ELZ77_04210 ENOG4105CHU acetyl-coa acetyltransferase ELZ77_04225 ENOG4105CHR reductase ELZ77_04235 ENOG4107QNK )-transporter ELZ77_04245 ENOG4105RQF LysR family Transcriptional regulator ELZ77_04250 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ELZ77_04255 ENOG4105DDV Transcriptional regulator (LacI family ELZ77_04285 ENOG4105CPC Aldo Keto reductase ELZ77_04290 ENOG4105SUV lipoprotein YgdR ELZ77_04295 ENOG4105EE5 Membrane protein terC ELZ77_04310 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ELZ77_04330 ENOG4105IPU prepilin peptidase dependent protein A ELZ77_04335 ENOG4105JCS prepilin peptidase dependent protein ELZ77_04340 ENOG4105SEN Protein of unknown function (DUF2509) ELZ77_04345 ENOG4105RVB Prepilin peptidase dependent protein c ELZ77_04350 ENOG4105DSY exodeoxyribonuclease V, gamma ELZ77_04355 ENOG4107QXK peptidase ELZ77_04360 ENOG4107QKA exodeoxyribonuclease V beta ELZ77_04365 ENOG4107QYX exodeoxyribonuclease v alpha ELZ77_04370 ENOG4108EKC n-acetylglutamate synthase ELZ77_04375 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ELZ77_04385 ENOG4105CA3 membrane-bound lytic murein transglycosylase ELZ77_04390 ENOG4105CUZ uba thif-type nad fad binding protein ELZ77_04395 ENOG4105FR1 rard protein ELZ77_04405 ENOG4105C9B Cysteine desulfurase ELZ77_04410 ENOG4105M5B (LipO)protein ELZ77_04420 ENOG4105M08 Membrane ELZ77_04430 ENOG4107EDW L-fucose operon activator ELZ77_04450 ENOG4105EDR glucose galactose transporter ELZ77_04455 ENOG4107W7X Aldolase ELZ77_04475 ENOG4105EJQ L-serine dehydratase ELZ77_04480 ENOG4105C44 Serine transporter ELZ77_04485 ENOG4105EWT decarboxylase family ELZ77_04505 ENOG4105WP7 tRNA pseudouridine synthase C ELZ77_04510 ENOG4105DR9 pseudouridine synthase ELZ77_04515 ENOG4105QDK Flavodoxin ELZ77_04525 ENOG4105DJB Major Facilitator Superfamily ELZ77_04530 ENOG4105EQX glucarate dehydratase ELZ77_04535 ENOG4105EQX glucarate dehydratase ELZ77_04545 ENOG4105BZU Histidine kinase ELZ77_04550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ELZ77_04555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ELZ77_04560 ENOG4105X54 addiction module antidote protein ELZ77_04590 ENOG4105NEV Fimbrial ELZ77_04595 ENOG4108FZ9 Chaperone ELZ77_04610 ENOG4105DXN mazG family ELZ77_04625 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ELZ77_04630 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ELZ77_04635 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ELZ77_04670 ENOG4105DTT CRISPR-associated helicase, cas3 ELZ77_04685 ENOG41060M0 Crispr-associated protein, cse4 family ELZ77_04690 ENOG4108VWQ crispr-associated protein ELZ77_04700 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) ELZ77_04705 ENOG4105PWE CRISPR-associated protein cas2 ELZ77_04710 ENOG4108MXK alkaline phosphatase isozyme conversion ELZ77_04765 ENOG4108K5P (LipO)protein ELZ77_04775 ENOG4105KZM cytoplasmic protein ELZ77_04780 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ELZ77_04785 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ELZ77_04795 ENOG4105MVE transcriptional regulator ELZ77_04805 ENOG4105G63 Type III effector Hrp-dependent ELZ77_04815 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ELZ77_04820 ENOG4105EXW epimerase dehydratase ELZ77_04830 ENOG4105JQN Transcriptional regulator ELZ77_04835 ENOG4105C0R drug resistance transporter emrb qaca subfamily ELZ77_04855 ENOG4105MEW serine threonine protein phosphatase ELZ77_04900 ENOG41090HZ type iii secretion ELZ77_04905 ENOG4105K44 type iii secretion ELZ77_04910 ENOG4108N8R Invasion protein ELZ77_04915 ENOG4108HR8 type iii secretion ELZ77_04920 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone ELZ77_04930 ENOG41077MC Secretory protein (Associated with virulence) ELZ77_04935 ENOG41078G4 surface presentation of ELZ77_04940 ENOG4105T85 surface presentation of antigens protein ELZ77_04945 ENOG41075IY surface presentation of antigens protein SpaP ELZ77_04955 ENOG4108TN6 type iii secretion ELZ77_04970 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE ELZ77_04990 ENOG41079WB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ELZ77_05005 ENOG410641W Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear ELZ77_05015 ENOG4108YAB Invasion protein ELZ77_05025 ENOG4108RC9 Type III secretion system protein ELZ77_05030 ENOG4105Y7Q type iii secretion ELZ77_05035 ENOG4106BTR ELZ77_05040 ENOG4108RBT type iii secretion ELZ77_05075 ENOG4105CC5 ABC transporter ELZ77_05080 ENOG4105CC5 ABC transporter ELZ77_05085 ENOG4105DIK (ABC) transporter ELZ77_05105 ENOG4105C45 hydrogenase expression formation protein (HypE) ELZ77_05110 ENOG4105CQS hydrogenase expression formation protein HypD ELZ77_05115 ENOG41083WG hydrogenase assembly chaperone ELZ77_05120 ENOG4107RSS Hydrogenase accessory protein HypB ELZ77_05125 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ELZ77_05135 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA ELZ77_05140 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) ELZ77_05145 ENOG4107R30 NADH dehydrogenase ELZ77_05150 ENOG4107TDF Formate hydrogenlyase subunit 4 ELZ77_05155 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ELZ77_05160 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit ELZ77_05165 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit ELZ77_05175 ENOG4108MG9 hydrogenase 3 maturation protease ELZ77_05185 ENOG4108RC0 Electron transport protein ELZ77_05190 ENOG4105C8H hydrogenase maturation protein Hypf ELZ77_05210 ENOG4105C2X Arabinose 5-phosphate isomerase ELZ77_05215 ENOG410804X Transcriptional regulator ELZ77_05220 ENOG4105J92 DNA-binding transcriptional activator GutM ELZ77_05230 ENOG4105VI0 Pts system, glucitol sorbitol-specific ELZ77_05235 ENOG4105DZY Pts system, glucitol sorbitol-specific ELZ77_05240 ENOG410787A Pts system, glucitol sorbitol-specific ELZ77_05245 ENOG4105CVE Lytic murein transglycosylase ELZ77_05255 ENOG4107TH8 cina domain protein ELZ77_05275 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ELZ77_05280 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ELZ77_05295 ENOG4107VXZ Hydrolase ELZ77_05300 ENOG4105W39 Membrane ELZ77_05320 ENOG4105C0R drug resistance transporter emrb qaca subfamily ELZ77_05325 ENOG4105CW7 secretion protein, HlyD family ELZ77_05330 ENOG4105NTK Transcriptional repressor Mpra ELZ77_05340 ENOG4105GIJ Glycine betaine ELZ77_05345 ENOG4108HQS Glycine betaine ELZ77_05350 ENOG4108IJ7 Glycine betaine ELZ77_05355 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ELZ77_05370 ENOG4105WAZ (Glutaredoxin-like protein) NrdH ELZ77_05380 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ELZ77_05390 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) ELZ77_05395 ENOG4108WMJ Protein of unknown function (DUF2002) ELZ77_05400 ENOG4108RNS Exports L-alanine (By similarity) ELZ77_05410 ENOG4108X73 DNA- binding protein ELZ77_05420 ENOG4108V62 Rhodanese domain protein ELZ77_05425 ENOG41080HT Transcriptional regulator, arsr family ELZ77_05430 ENOG4105VPI YqaE family transport protein ELZ77_05440 ENOG4109066 lysm domain bon superfamily protein ELZ77_05445 ENOG4108PVQ transcriptional regulator ELZ77_05450 ENOG4105C85 amino acid ELZ77_05455 ENOG4108JPW Aminotransferase ELZ77_05460 ENOG4105C26 Dehydrogenase ELZ77_05465 ENOG4105D5U fad dependent oxidoreductase ELZ77_05495 ENOG4105DHQ Histidine kinase ELZ77_05515 ENOG4108MJ5 VirK protein ELZ77_05520 ENOG4105VRE Pentapeptide repeat protein ELZ77_05535 ENOG4107RNH Outer membrane receptor FepA ELZ77_05540 ENOG4105NIV Esterase ELZ77_05575 ENOG4105PTU response to oxidative stress ELZ77_05580 ENOG4105EXC Acyl-transferase ELZ77_05585 ENOG4105Y50 Virulence Protein ELZ77_05595 ENOG4105KT5 UmuD protein ELZ77_05660 ENOG4105DFP Integrase ELZ77_05675 ENOG4105BZ1 (ABC) transporter ELZ77_05695 ENOG4108Z1B Cyclase dehydrase ELZ77_05705 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ELZ77_05710 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ELZ77_05735 ENOG4108JU6 CBS domain protein ELZ77_05740 ENOG4106KVJ cytochrome C assembly protein ELZ77_05750 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ELZ77_05775 ENOG4108KHX Diguanylate cyclase ELZ77_05780 ENOG4108WS1 ELZ77_05785 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ELZ77_05790 ENOG4105EHE chorismate mutase- prephenate dehydrogenase ELZ77_05800 ENOG4105CQC Prephenate dehydratase ELZ77_05810 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ELZ77_05820 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ELZ77_05825 ENOG4105C34 Pseudouridine synthase ELZ77_05830 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ELZ77_05835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ELZ77_05870 ENOG4105CSH Transporter ELZ77_05875 ENOG4105T42 (LipO)protein ELZ77_05880 ENOG4105JIM Phosphatidylserine synthase ELZ77_05885 ENOG4105CD5 CoA-binding domain protein ELZ77_05890 ENOG4106IUH DTW domain containing protein ELZ77_05895 ENOG4105K63 Thioredoxin ELZ77_05900 ENOG4105EIB trna rrna methyltransferase ELZ77_05920 ENOG41090KR LysR family transcriptional Regulator ELZ77_05925 ENOG4105C1J atp-dependent rna helicase ELZ77_05935 ENOG4108IYU L-aspartate oxidase ELZ77_05965 ENOG4105WMJ Positive regulator of sigma E, RseC MucC ELZ77_05980 ENOG4105C3F Signal peptidase i ELZ77_06010 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ELZ77_06015 ENOG4105DND Transcriptional regulator ELZ77_06020 ENOG4105FCD Major Facilitator ELZ77_06025 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ELZ77_06030 ENOG4106G6Q Transcriptional regulator ELZ77_06045 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB ELZ77_06050 ENOG4108Z6B deaminase ELZ77_06055 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ELZ77_06065 ENOG4108ETH Formylglycinamide ribotide synthetase ELZ77_06070 ENOG4107WP9 Histidine kinase ELZ77_06075 ENOG4108SKK alpha helix protein ELZ77_06080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ELZ77_06085 ENOG4108YZA Nitrogen regulatory protein pii ELZ77_06090 ENOG4105DUX Transporter ELZ77_06095 ENOG4105CXN decarboxylase ELZ77_06105 ENOG4108M3R transcriptional activator CadC ELZ77_06110 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ELZ77_06115 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ELZ77_06120 ENOG4105D8G Major Facilitator superfamily ELZ77_06125 ENOG4108MN2 Stationary phase inducible protein CsiE ELZ77_06135 ENOG4105D7X high-affinity nickel-transporter ELZ77_06140 ENOG410810Y Sulfite reductase ELZ77_06145 ENOG4107SHJ sulfite reductase subunit b ELZ77_06160 ENOG4105ECY inositol monophosphatase ELZ77_06180 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ELZ77_06200 ENOG4108ZIT Ferredoxin, 2FE-2S ELZ77_06205 ENOG4105WVQ Fe-S assembly protein IscX ELZ77_06220 ENOG4105YYA enhanced serine sensitivity protein SseB ELZ77_06235 ENOG4105KHC sulfurtransferase ELZ77_06240 ENOG4105DN3 alpha-2-macroglobulin domain protein ELZ77_06245 ENOG4108JQB penicillin-binding protein 1C ELZ77_06250 ENOG4107QY8 reductase ELZ77_06255 ENOG4105QAX Iron-sulfur ELZ77_06295 ENOG4105N21 Membrane ELZ77_06300 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ELZ77_06310 ENOG4105VPD cellular component movement ELZ77_06350 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ELZ77_06370 ENOG4105EQR Transposase IS116 IS110 IS902 ELZ77_06415 ENOG41066DY Membrane ELZ77_06420 ENOG4108ZMA Outer membrane lipoprotein ELZ77_06425 ENOG41062G3 Protein of unknown function (DUF2633) ELZ77_06440 ENOG4105C9X ppx gppa phosphatase ELZ77_06445 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ELZ77_06450 ENOG4108V3E phosphoribosylglycinamide formyltransferase ELZ77_06465 ENOG4105C2W permease ELZ77_06475 ENOG4105K89 arsenate reductase ELZ77_06480 ENOG4105ERG peptidase m48, ste24p ELZ77_06485 ENOG4105C02 permease ELZ77_06490 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ELZ77_06505 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ELZ77_06510 ENOG4105RH4 Glycine cleavage system transcriptional repressor ELZ77_06530 ENOG4105CGZ zinc metallopeptidase ELZ77_06550 ENOG4105KUZ arsenate reductase ELZ77_06560 ENOG4105BZS acriflavin resistance protein ELZ77_06565 ENOG4105BZU Histidine kinase ELZ77_06570 ENOG4105BZ8 glutamate synthase ELZ77_06585 ENOG4108PVD exported protein ELZ77_06595 ENOG4105CV1 Transketolase (EC 2.2.1.1) ELZ77_06605 ENOG4105C6K Malic enzyme ELZ77_06610 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place ELZ77_06615 ENOG4106S4J ethanolamine utilization protein EutP ELZ77_06620 ENOG4105NDK ethanolamine utilization protein ELZ77_06625 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase ELZ77_06630 ENOG4108IJ2 phosphate acetyltransferase ELZ77_06635 ENOG4105KNY Microcompartments protein ELZ77_06640 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml ELZ77_06645 ENOG4108EKI Dehydrogenase ELZ77_06650 ENOG4107RWI ethanolamine utilization protein eutJ ELZ77_06665 ENOG4105ENY Ethanolamine utilization protein eutH ELZ77_06670 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase ELZ77_06675 ENOG4105CPD ethanolamine ammonia-lyase ELZ77_06685 ENOG4106D67 ethanolamine utilization protein ELZ77_06690 ENOG4108X49 Ethanolamine utilization protein EutK ELZ77_06695 ENOG4108K3Z AraC family transcriptional regulator ELZ77_06710 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase ELZ77_06720 ENOG4105QZU Inner membrane protein YfeZ ELZ77_06725 ENOG4105E7K (LipO)protein ELZ77_06730 ENOG4105EZR dyp-type peroxidase family protein ELZ77_06735 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr ELZ77_06740 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ELZ77_06750 ENOG4105ECW sulfate abc transporter ELZ77_06755 ENOG4108IJ6 ABC transporter ELZ77_06760 ENOG4105C6T cysteine synthase ELZ77_06775 ENOG4105M0Y ELZ77_06780 ENOG41089BK Glutamine amido-transferase ELZ77_06800 ENOG4105C5Y PTS System ELZ77_06810 ENOG4105KZ7 phosphocarrier protein hpr ELZ77_06815 ENOG4105C6T cysteine synthase ELZ77_06835 ENOG4105VRT cytoplasmic protein ELZ77_06840 ENOG4105DHU Bile acid ELZ77_06845 ENOG4108M0I Transcriptional regulator ELZ77_06850 ENOG4108NFH Sugar hydrolase ELZ77_06855 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) ELZ77_06860 ENOG4105EAA nucleoside ELZ77_06890 ENOG4105GXM Putative transcription regulator (DUF1323) ELZ77_06895 ENOG4105HZG regulatoR ELZ77_06905 ENOG4108KMM Diguanylate cyclase ELZ77_06910 ENOG4105D9N nucleoside ELZ77_06920 ENOG4109076 Conserved Protein ELZ77_06925 ENOG4105CPC Aldo Keto reductase ELZ77_06935 ENOG4107RA9 decarboxylase ELZ77_06950 ENOG4105CHM Aminotransferase ELZ77_06960 ENOG4105D1S lipid A biosynthesis ELZ77_06965 ENOG4105W9M Membrane ELZ77_06970 ENOG4105CXY transporter ELZ77_06980 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC ELZ77_06995 ENOG4108NC2 Outer membrane protease ELZ77_07020 ENOG4105EXC Acyl-transferase ELZ77_07025 ENOG4105CKK Glycosyl transferase, family 2 ELZ77_07030 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) ELZ77_07050 ENOG4105S64 Formate nitrite transporter ELZ77_07055 ENOG410903C (LipO)protein ELZ77_07060 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ELZ77_07065 ENOG4105KZW UPF0381 protein ELZ77_07080 ENOG4108BY2 phosphohistidine phosphatase ELZ77_07090 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ELZ77_07105 ENOG4105EJ9 Membrane ELZ77_07110 ENOG4108BPE -transporting atpase ELZ77_07115 ENOG4105MH2 YfcL protein ELZ77_07120 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ELZ77_07125 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ELZ77_07145 ENOG4105R8V Transcriptional regulator ELZ77_07160 ENOG4106WZ1 flagella biosynthesis regulator ELZ77_07170 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ELZ77_07180 ENOG4105DQR SNARE associated Golgi ELZ77_07200 ENOG4105E96 Colicin v production protein ELZ77_07205 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ELZ77_07210 ENOG4108JUB Transcriptional regulator ELZ77_07225 ENOG4105E5D amino acid ELZ77_07230 ENOG4106M28 alanine racemase domain protein ELZ77_07235 ENOG4108IQI permease ELZ77_07240 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ELZ77_07250 ENOG4105E89 ABC transporter ELZ77_07255 ENOG4105E89 ABC transporter ELZ77_07260 ENOG4105DSP amino acid AbC transporter ELZ77_07265 ENOG4106YG3 ABC transporter ELZ77_07270 ENOG4108JEH abc transporter atp-binding protein ELZ77_07275 ENOG4105ECP epimerase ELZ77_07285 ENOG4108SHQ Glutathione S-transferase ELZ77_07290 ENOG4108RE9 Phosphodiesterase ELZ77_07295 ENOG4105PTV Nudix Hydrolase ELZ77_07300 ENOG4105K2J Transcriptional regulator ELZ77_07310 ENOG4106ETB IIa component ELZ77_07320 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC ELZ77_07330 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ELZ77_07335 ENOG4105CSX c4-dicarboxylate anaerobic carrier ELZ77_07340 ENOG4105C6K Malic enzyme ELZ77_07345 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ELZ77_07365 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 ELZ77_07370 ENOG4107QWE )-transporter ELZ77_07385 ENOG4105CHM Aminotransferase ELZ77_07420 ENOG4105GKE subunit e ELZ77_07425 ENOG4107QIZ NADH dehydrogenase ELZ77_07445 ENOG4107UFS subunit j ELZ77_07455 ENOG4105D65 subunit l ELZ77_07460 ENOG4105C8S subunit m ELZ77_07470 ENOG4107R88 Chemotaxis protein (CheV) ELZ77_07480 ENOG4107YB6 acetyltransferase, (GNAT) family ELZ77_07485 ENOG4105TNS Conserved Protein ELZ77_07490 ENOG4105E4F Isochorismate synthase ELZ77_07505 ENOG4108IPT Naphthoate synthase ELZ77_07515 ENOG4105CEY Amp-dependent synthetase and ligase ELZ77_07520 ENOG4106GZG polymyxin resistance protein B ELZ77_07570 ENOG4108UII YfaZ family ELZ77_07580 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is ELZ77_07590 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ELZ77_07600 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ELZ77_07610 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ELZ77_07615 ENOG4105GZI Transcriptional regulator ELZ77_07620 ENOG4105CZM Major Facilitator ELZ77_07630 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ELZ77_07635 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ELZ77_07660 ENOG4105CXK mandelate racemase muconate lactonizing ELZ77_07670 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ELZ77_07675 ENOG4105BZU Histidine kinase ELZ77_07680 ENOG41068CG regulatoR ELZ77_07685 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC ELZ77_07690 ENOG4105FCK Membrane ELZ77_07695 ENOG4105CJ2 (LipO)protein ELZ77_07700 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ELZ77_07705 ENOG4105CF1 Alkylated DNA repair protein ELZ77_07710 ENOG4105IBP Cyclic peptide transporter ELZ77_07720 ENOG4108ZNS ferredoxin-type protein NapF ELZ77_07725 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase ELZ77_07740 ENOG4105GXZ Ferredoxin-type protein NapH ELZ77_07745 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) ELZ77_07750 ENOG4105CUW cytochrome C-TYPE protein ELZ77_07780 ENOG4105DA4 cytochrome c-type biogenesis protein ELZ77_07800 ENOG4105WH1 Two component transcriptional regulator luxr family ELZ77_07870 ENOG4105CFI type iii restriction protein res subunit ELZ77_07880 ENOG4105D7V transposase ELZ77_07885 ENOG4105I08 Pseudouridine synthase ELZ77_07890 ENOG4105C2C drug resistance transporter, Bcr CflA ELZ77_07895 ENOG4105HG6 ELZ77_07900 ENOG4108JQ5 ABC transporter ELZ77_07905 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ELZ77_07910 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ELZ77_07915 ENOG4105E43 Extracellular solute-binding protein, family 5 ELZ77_07920 ENOG4105CXC rtn protein ELZ77_07925 ENOG4107TT5 NLP P60 protein ELZ77_07930 ENOG41076MN Phosphoesterase, PA-phosphatase related ELZ77_07935 ENOG4105CKI cobalamin synthesis protein ELZ77_07940 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ELZ77_07950 ENOG4105KRS Proteinase inhibitor ELZ77_07965 ENOG4105S8Q sugar efflux transporter ELZ77_07975 ENOG4105DE4 1-phosphofructokinase ELZ77_07980 ENOG4105DM4 PTS System ELZ77_07990 ENOG4105HMI Membrane ELZ77_07995 ENOG4105DUM transcriptional regulator, lysR family ELZ77_08000 ENOG4108IQI permease ELZ77_08010 ENOG4105D05 Receptor ELZ77_08015 ENOG4105CXY transporter ELZ77_08020 ENOG4105EAC phosphoserine phosphatase ELZ77_08025 ENOG4105EJQ L-serine dehydratase ELZ77_08045 ENOG4105DHF Membrane ELZ77_08050 ENOG41060NJ transcriptional regulator ELZ77_08055 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator ELZ77_08060 ENOG4105C2J ABC transporter ELZ77_08065 ENOG4107SDZ Galactoside transport system permease protein mglC ELZ77_08070 ENOG4107SJI Dehydrogenase ELZ77_08075 ENOG4105BZ8 glutamate synthase ELZ77_08080 ENOG4105Y9N Membrane ELZ77_08085 ENOG4107GZ4 SanA protein ELZ77_08095 ENOG41067MG lrgb family ELZ77_08125 ENOG4108RXX maleylacetoacetate isomerase ELZ77_08130 ENOG4105MSY salicylate hydroxylase ELZ77_08135 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ELZ77_08145 ENOG4105ETP RND efflux system, outer membrane lipoprotein ELZ77_08150 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ELZ77_08155 ENOG4105KHU inner membrane protein YohD ELZ77_08160 ENOG41069YE inner membrane protein yohC ELZ77_08170 ENOG4105CXG d-lactate dehydrogenase ELZ77_08175 ENOG4107QK4 glycoside hydrolase, family 3 domain protein ELZ77_08185 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component ELZ77_08190 ENOG4108IJ8 ABC transporter ELZ77_08195 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component ELZ77_08210 ENOG4108HRK Histidine kinase ELZ77_08215 ENOG4108NEV two component transcriptional regulator, LytTR family ELZ77_08220 ENOG4108W15 Protein of unknown function (DUF1456) ELZ77_08230 ENOG4108YCW (LipO)protein ELZ77_08240 ENOG4105D1F ATP-binding protein ELZ77_08255 ENOG4108MQF Chaperone ELZ77_08260 ENOG4105CW0 outer membrane usher protein ELZ77_08270 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly ELZ77_08280 ENOG4105DWF phosphomethylpyrimidine kinase ELZ77_08285 ENOG4105FDP GntR family transcriptional regulator ELZ77_08290 ENOG4108TFM Kinase, PfkB family ELZ77_08295 ENOG4108KD5 ADP-ribosylation crystallin J1 ELZ77_08300 ENOG4105EAA nucleoside ELZ77_08305 ENOG4105EIE fructose-bisphosphate aldolase ELZ77_08320 ENOG41090V3 Tir chaperone protein (CesT) family ELZ77_08420 ENOG4105E3W Two component transcriptional regulator (Winged helix family ELZ77_08425 ENOG4105EB3 Histidine kinase ELZ77_08455 ENOG4105R8A Heat shock protein ELZ77_08460 ENOG4105D03 DNA-3-methyladenine glycosylase II ELZ77_08465 ENOG4105BZU Histidine kinase ELZ77_08480 ENOG4108GAE asmA family ELZ77_08485 ENOG4105EE5 Membrane protein terC ELZ77_08490 ENOG4105DAY polysaccharide export protein ELZ77_08495 ENOG4105KJF protein tyrosine phosphatase ELZ77_08500 ENOG4105D75 Capsular exopolysaccharide family ELZ77_08505 ENOG41090RK glycosyl transferase ELZ77_08510 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB ELZ77_08515 ENOG4107RXY Glycosyl transferase ELZ77_08520 ENOG4108NYJ Colanic acid ELZ77_08525 ENOG4105ECJ Glycosyl Transferase ELZ77_08530 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF ELZ77_08535 ENOG4105C0K Gdp-mannose 4,6-dehydratase ELZ77_08540 ENOG4105C30 Nad-dependent epimerase dehydratase ELZ77_08550 ENOG4106CD9 glycosyl transferase group 1 ELZ77_08555 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ELZ77_08560 ENOG4107QKV phosphomannomutase ELZ77_08565 ENOG4105D3Q Sugar transferase ELZ77_08570 ENOG4105PSV Polysaccharide Biosynthesis Protein ELZ77_08575 ENOG4105C74 pyruvyl transferase ELZ77_08580 ENOG4107T8Q Glycosyl transferase (Group 1 ELZ77_08585 ENOG4105G1A colanic acid biosynthesis protein ELZ77_08590 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ELZ77_08595 ENOG4105C1B dTDP-glucose 4-6-dehydratase ELZ77_08600 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase ELZ77_08605 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ELZ77_08610 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase ELZ77_08615 ENOG4107QK7 reductase ELZ77_08620 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ELZ77_08625 ENOG4105FAW cDP-glucose 4,6-dehydratase ELZ77_08630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ELZ77_08635 ENOG4108SMP Nad-dependent epimerase dehydratase ELZ77_08640 ENOG4105FB1 Polysaccharide Biosynthesis Protein ELZ77_08645 ENOG4107YYJ Glycosyl transferase, family 2 ELZ77_08650 ENOG4108TJN glycosyl transferase group 1 ELZ77_08655 ENOG4108KBE Glycosyl transferase, family 2 ELZ77_08660 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ELZ77_08665 ENOG4106ECQ phosphomannomutase ELZ77_08670 ENOG4105D3Q Sugar transferase ELZ77_08675 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ELZ77_08685 ENOG4105C6Y Udp-glucose 6-dehydrogenase ELZ77_08690 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) ELZ77_08695 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ELZ77_08740 ENOG4108535 NAD dependent epimerase/dehydratase family ELZ77_08745 ENOG4105EQ1 Transcriptional regulator ELZ77_08755 ENOG4105CUB amino acid ELZ77_08760 ENOG4105CJB Exodeoxyribonuclease I ELZ77_08775 ENOG4108J2R molybdopterin oxidoreductase ELZ77_08780 ENOG4105QAX Iron-sulfur ELZ77_08785 ENOG4108NWD Cytochrome ELZ77_08795 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) ELZ77_08800 ENOG4105DR8 Membrane ELZ77_08810 ENOG4105JZC GHMP kinase ELZ77_08815 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ELZ77_08820 ENOG4105KTW ethanolamine utilization protein ELZ77_08825 ENOG4105M3W utilization protein ELZ77_08835 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) ELZ77_08840 ENOG4108EKI Dehydrogenase ELZ77_08845 ENOG4108EKI Dehydrogenase ELZ77_08855 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml ELZ77_08865 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) ELZ77_08870 ENOG4105S3V Carbon dioxide concentrating mechanism protein ELZ77_08885 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit ELZ77_08890 ENOG4108ZFT Dehydratase small subunit ELZ77_08895 ENOG4105YCI dehydratase medium subunit ELZ77_08900 ENOG4105DMB glycerol dehydratase ELZ77_08905 ENOG4105EHR propanediol utilization protein pduB ELZ77_08910 ENOG4105KNY Microcompartments protein ELZ77_08915 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ELZ77_08920 ENOG4107XVH Transcriptional regulator ELZ77_08935 ENOG41081F0 Precorrin-8x methylmutase ELZ77_08945 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase ELZ77_08950 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase ELZ77_08955 ENOG4105CIA precorrin-4 C(11)-methyltransferase ELZ77_08960 ENOG4108P62 biosynthesis protein (CbiG) ELZ77_08965 ENOG4105E4R Precorrin-3B C17-methyltransferase ELZ77_08970 ENOG4105QUC reductase ELZ77_08980 ENOG4105DVK Precorrin-2 c20-methyltransferase ELZ77_08985 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) ELZ77_08995 ENOG4108V4M Cobalt abc transporter ELZ77_09000 ENOG4108JJB ABC transporter ELZ77_09010 ENOG4108YZT Adenosylcobinamide kinase ELZ77_09025 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ELZ77_09035 ENOG4105UQX Mate efflux family protein ELZ77_09060 ENOG4105FYV Amp nucleosidase ELZ77_09070 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ELZ77_09075 ENOG4105KVH Transcriptional regulator ELZ77_09175 ENOG4107XHZ cytoplasmic chaperone TorD family protein ELZ77_09180 ENOG4108UQ5 membrane protein YcdZ ELZ77_09185 ENOG4105P8Q Curli production assembly transport component CsgG ELZ77_09190 ENOG4108WYR Curli production assembly transport component, CsgF ELZ77_09195 ENOG4108XDW curli assembly protein CsgE ELZ77_09200 ENOG41086KC Transcriptional regulator ELZ77_09235 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) ELZ77_09250 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) ELZ77_09255 ENOG4105NAC (LipO)protein ELZ77_09260 ENOG4108W47 Acidic protein msyB ELZ77_09275 ENOG4105D1S lipid A biosynthesis ELZ77_09285 ENOG4108YYC ycei family ELZ77_09290 ENOG4105DS1 cytochrome b561 ELZ77_09295 ENOG4106974 biofilm formation ELZ77_09305 ENOG4105PVA Biofilm formation regulatory protein BssS ELZ77_09310 ENOG4105MEA DNA damage-inducible protein i ELZ77_09320 ENOG4105F3T (LipO)protein ELZ77_09325 ENOG4105E9S glutaredoxin 2 ELZ77_09335 ENOG4105D9U N-acetyltransferase ELZ77_09350 ENOG4105CJR Integral membrane protein (MviN ELZ77_09355 ENOG4105QVD Flagella synthesis protein FlgN ELZ77_09360 ENOG4105M9M anti-sigma28 factor FlgM ELZ77_09365 ENOG4105CKS Flagella basal body P-ring formation protein flgA ELZ77_09375 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ELZ77_09380 ENOG4108ZC9 flagellar basal-body rod protein flgc ELZ77_09385 ENOG4105W00 Flagellar hook capping protein ELZ77_09390 ENOG4105BZE flagellar hook protein, FlgE ELZ77_09395 ENOG4108KPB Flagellar basal-body rod protein FlgF ELZ77_09400 ENOG4105CGA flagellar basal-body rod protein FlgG ELZ77_09415 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ELZ77_09420 ENOG4105E1Q flagellar hook-associated protein ELZ77_09425 ENOG4105DTJ flagellar hook-associated protein ELZ77_09435 ENOG41071G1 Uncharacterized protein YceQ ELZ77_09440 ENOG4105EI2 Pseudouridine synthase ELZ77_09450 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ELZ77_09470 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ELZ77_09475 ENOG4105CHR reductase ELZ77_09480 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ELZ77_09485 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ELZ77_09490 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ELZ77_09495 ENOG4105HHA aminodeoxychorismate lyase ELZ77_09505 ENOG4107QRG dna polymerase iii ELZ77_09510 ENOG4105F8V Hydrolase, tatD family ELZ77_09520 ENOG4105CNM Receptor ELZ77_09525 ENOG4105K59 histidine triad (HIT) protein ELZ77_09530 ENOG41090DQ Lipoprotein ELZ77_09535 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) ELZ77_09555 ENOG4105CEP NADH dehydrogenase ELZ77_09560 ENOG4107MBR 17 kDa surface antigen ELZ77_09565 ENOG4108IND Tetr family transcriptional regulator ELZ77_09570 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction ELZ77_09575 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ELZ77_09580 ENOG4108JA2 transcriptioN-repair coupling factor ELZ77_09585 ENOG4105D60 lipoprotein releasing system transmembrane protein ELZ77_09595 ENOG4105D60 lipoprotein releasing system transmembrane protein ELZ77_09605 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ELZ77_09610 ENOG4107RUE extracellular solute-binding protein family 1 ELZ77_09615 ENOG4105D38 putrescine abc transporter ELZ77_09625 ENOG4105F38 ABC transporter, permease ELZ77_09645 ENOG4105EZE Cupin 4 family protein ELZ77_09685 ENOG4108R99 pseudouridine synthase ELZ77_09690 ENOG4108HMX isocitrate dehydrogenase (NADP) ELZ77_09725 ENOG4108TMH cytolethal distending toxin ELZ77_09730 ENOG4105Y50 Virulence Protein ELZ77_09735 ENOG4106F2Y RICIN ELZ77_09740 ENOG41060EU Cold shock-like protein ELZ77_09760 ENOG4105H38 Membrane ELZ77_09785 ENOG4108ZNX Heat shock protein ELZ77_09815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ELZ77_09825 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) ELZ77_09830 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) ELZ77_09835 ENOG4105D64 Mechanosensitive ion channel ELZ77_09850 ENOG4108MEK Metal-binding protein YodA ELZ77_09865 ENOG4108Z6Z Transcriptional regulator ELZ77_09875 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) ELZ77_09890 ENOG4108YS1 cytoplasmic protein ELZ77_09895 ENOG4105YP6 Domain of unknown function (DUF1869) ELZ77_09910 ENOG4105Y3U Transglycosylase-associated protein ELZ77_09915 ENOG4106G4W ELZ77_09920 ENOG4105UCG Domain of unknown function (DUF333) ELZ77_09930 ENOG4105K78 MarR family Transcriptional regulator ELZ77_09935 ENOG4105DJ2 Major Facilitator Superfamily ELZ77_09940 ENOG4105R1U AraC Family Transcriptional Regulator ELZ77_09955 ENOG4108KXH Ybak prolyl-tRNA synthetase associated ELZ77_09960 ENOG4108KHP Diguanylate cyclase ELZ77_09975 ENOG4105CYN Serine protein kinase ELZ77_09980 ENOG4105GNX MltA-interacting MipA family protein ELZ77_09985 ENOG4105C4X radical SAM domain protein ELZ77_09990 ENOG4105CV8 reductase ELZ77_09995 ENOG4105DSB aldose 1-epimerase ELZ77_10005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ELZ77_10015 ENOG4105VUT cytoplasmic protein ELZ77_10020 ENOG4108RWI nicotinamidase ELZ77_10025 ENOG4105HDK L-asparaginase ELZ77_10030 ENOG4105D07 Signal peptide peptidase, SppA ELZ77_10035 ENOG41069NU Nitroreductase ELZ77_10040 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) ELZ77_10045 ENOG4108IYH Dna topoisomerase ELZ77_10050 ENOG4105D82 Glutamate dehydrogenase ELZ77_10055 ENOG4105MTM Protein of unknown function (DUF1496) ELZ77_10060 ENOG4105M6F mutator MutT protein ELZ77_10065 ENOG4105CGK Exodeoxyribonuclease III ELZ77_10085 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) ELZ77_10095 ENOG4108SPG Periplasmic Protein ELZ77_10100 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) ELZ77_10110 ENOG4105KKI DNA-binding transcriptional activator OsmE ELZ77_10120 ENOG4105VZJ PTS System ELZ77_10125 ENOG4105CK1 PTS System ELZ77_10130 ENOG4105VCP PTS System ELZ77_10135 ENOG4105EZV Transcriptional regulator ELZ77_10140 ENOG4105F8D glycoside hydrolase family 4 ELZ77_10150 ENOG4105CH6 catalase ELZ77_10160 ENOG4108ETY sodium dicarboxylate symporter ELZ77_10165 ENOG4107K5X Membrane-bound metal-dependent hydrolase ELZ77_10170 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 ELZ77_10175 ENOG4107PN8 YfeABCD locus regulator ELZ77_10185 ENOG4105P10 Uncharacterized protein ydiZ ELZ77_10190 ENOG4105DE4 1-phosphofructokinase ELZ77_10195 ENOG4108NE3 Salt-induced outer membrane protein ELZ77_10220 ENOG4105K25 O-Antigen polymerase ELZ77_10235 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ELZ77_10240 ENOG41082NX 50s ribosomal protein l35 ELZ77_10245 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ELZ77_10260 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ELZ77_10265 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ELZ77_10275 ENOG4108V06 Glutathione peroxidase ELZ77_10285 ENOG4108QBX (LipO)protein ELZ77_10300 ENOG4106EDX Hemin uptake protein ELZ77_10305 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ELZ77_10315 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ELZ77_10320 ENOG4105CEY Amp-dependent synthetase and ligase ELZ77_10325 ENOG41090P5 ferredoxin-like protein ELZ77_10330 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ELZ77_10335 ENOG4105C10 Electron transfer flavoprotein ELZ77_10340 ENOG4105CV7 Electron transfer flavoprotein ELZ77_10345 ENOG4105W4W Transcriptional regulator ELZ77_10350 ENOG4105C1G acyl-Coa dehydrogenase ELZ77_10355 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) ELZ77_10370 ENOG4105EMV Major Facilitator ELZ77_10375 ENOG4105EMV Major Facilitator ELZ77_10380 ENOG4105SUA Ydil protein ELZ77_10390 ENOG4105IPI Membrane ELZ77_10395 ENOG4105CQB FAD linked oxidase domain protein ELZ77_10400 ENOG4105KA0 thioesterase Superfamily protein ELZ77_10405 ENOG410671Z uncharacterized protein ydiH ELZ77_10410 ENOG4108ETY sodium dicarboxylate symporter ELZ77_10415 ENOG4108Z4V iron-sulfur cluster assembly ELZ77_10420 ENOG4105DIW FeS assembly protein SUFB ELZ77_10425 ENOG4105C3K feS assembly ATPase SufC ELZ77_10430 ENOG4105JRK feS assembly protein SufD ELZ77_10445 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ELZ77_10460 ENOG4105CA9 Pyruvate kinase ELZ77_10465 ENOG4105CUB amino acid ELZ77_10470 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) ELZ77_10480 ENOG4108RVA ribokinase ELZ77_10485 ENOG4105DB1 molybdopterin oxidoreductase ELZ77_10490 ENOG4106WHD Tetrathionate reductase ELZ77_10495 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ELZ77_10500 ENOG4106AFQ Histidine kinase ELZ77_10505 ENOG4108ZXC Two component transcriptional regulator, luxr family ELZ77_10510 ENOG4105RFR Protein of unknown function (DUF2767) ELZ77_10515 ENOG4107SEY Conserved Protein ELZ77_10520 ENOG4108XDN Transcriptional regulator ELZ77_10530 ENOG4105BZU Histidine kinase ELZ77_10565 ENOG4105ZQI secreted protein ELZ77_10580 ENOG4106FZW pathogenicity island effector protein ELZ77_10630 ENOG4106563 type III secretion system apparatus protein ELZ77_10635 ENOG4105UQF type iii secretion ELZ77_10640 ENOG4106H1D secretion system apparatus protein ELZ77_10650 ENOG4108JIR Flagellum-specific ATP synthase ELZ77_10665 ENOG41063Q7 Type III secretion system protein ELZ77_10670 ENOG4108HHI Type III secretion system protein ELZ77_10675 ENOG41083GP type iii secretion ELZ77_10680 ENOG4108TN6 type iii secretion ELZ77_10685 ENOG4108IUF type iii secretion ELZ77_10705 ENOG4108R6K riboflavin synthase, subunit alpha ELZ77_10710 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ELZ77_10715 ENOG4105CZQ inner membrane transport protein YdhC ELZ77_10720 ENOG4105F52 Transcriptional regulator ELZ77_10735 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ELZ77_10740 ENOG4105K4H Nlp p60 protein ELZ77_10745 ENOG4105M2J Glutaredoxin ELZ77_10755 ENOG4108UYE Lactoylglutathione lyase ELZ77_10760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ELZ77_10765 ENOG4108WUH Transcriptional regulator, TetR family ELZ77_10770 ENOG4105XZD Fe-S protein ELZ77_10775 ENOG4107RGM aldo keto reductase ELZ77_10780 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ELZ77_10785 ENOG4105DSW Fusaric acid resistance protein ELZ77_10790 ENOG4105Y49 secretion protein, HlyD family ELZ77_10805 ENOG4108XTF Outer Membrane Lipoprotein ELZ77_10815 ENOG410642K Lysozyme inhibitor ELZ77_10835 ENOG4108K3A Glutathione S-transferase ELZ77_10840 ENOG4105DUX Transporter ELZ77_10855 ENOG4108UQQ Electron transport complex ELZ77_10860 ENOG4105D6A Electron transport complex ELZ77_10880 ENOG4105M9B inner membrane protein ydgK ELZ77_10890 ENOG4106C6R beta-lactam resistance protein ELZ77_10895 ENOG4105D9R oxidoreductase ELZ77_10915 ENOG4106J39 exported protein ELZ77_10920 ENOG4105EIP mannose-6-phosphate isomerase ELZ77_10925 ENOG4107GFK fumarate ELZ77_10930 ENOG4105C9Q fumarate hydratase class II ELZ77_10940 ENOG4105JJR Histidine kinase ELZ77_10945 ENOG4105CPN adenine deaminase ELZ77_10950 ENOG4105FCK Membrane ELZ77_10965 ENOG4105RA2 Membrane ELZ77_10970 ENOG4105D5Q Arginine ornithine antiporter ELZ77_10975 ENOG4105C5D exported protein ELZ77_10985 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ELZ77_10990 ENOG4105DSF transport protein ELZ77_11010 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap ELZ77_11020 ENOG4105D94 Major Facilitator Superfamily ELZ77_11025 ENOG4106NZI LysR family Transcriptional regulator ELZ77_11030 ENOG4105DAG ROK family ELZ77_11035 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ELZ77_11045 ENOG4108IJ8 ABC transporter ELZ77_11050 ENOG4105E90 ABC transporter ELZ77_11055 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system ELZ77_11060 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component ELZ77_11065 ENOG4108NEM leader-binding protein dmsD ELZ77_11070 ENOG4107KGK dmso reductase anchor subunit ELZ77_11075 ENOG4105QAX Iron-sulfur ELZ77_11080 ENOG4107QY8 reductase ELZ77_11090 ENOG4108NEM leader-binding protein dmsD ELZ77_11095 ENOG4107KGK dmso reductase anchor subunit ELZ77_11105 ENOG4105C3J Cysteine desulfurase ELZ77_11110 ENOG4107QY8 reductase ELZ77_11115 ENOG4105KBG Protein of unknown function (DUF1161) ELZ77_11125 ENOG4108MK9 spermidine N(1)-acetyltransferase ELZ77_11145 ENOG4105CPQ Dehydrogenase ELZ77_11155 ENOG4105DEI Mannitol dehydrogenase ELZ77_11160 ENOG41061EV selenium-binding protein YdfZ ELZ77_11165 ENOG4107XBN GntR Family Transcriptional Regulator ELZ77_11170 ENOG4105EMU Dehydrogenase ELZ77_11175 ENOG4105DGW oligopeptidase A ELZ77_11190 ENOG4108WTK competence damage-inducible protein ELZ77_11195 ENOG4108YDI single-species biofilm formation on inanimate substrate ELZ77_11210 ENOG4108594 Permease of the drug metabolite transporter ELZ77_11215 ENOG4106DNR multiple antibiotic resistance protein ELZ77_11225 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes ELZ77_11240 ENOG4105EGI Transcriptional regulator ELZ77_11245 ENOG4105C26 Dehydrogenase ELZ77_11255 ENOG4105M0C cytoplasmic protein ELZ77_11260 ENOG4105FFC UPF0187 protein ELZ77_11285 ENOG4105MVP hydrogenase-1 operon protein HyaF ELZ77_11300 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit ELZ77_11305 ENOG4105DPX Hydrogenase, large subunit ELZ77_11320 ENOG4105C6F GntR Family Transcriptional Regulator ELZ77_11325 ENOG4105CPQ Dehydrogenase ELZ77_11330 ENOG4108I5G Major Facilitator superfamily ELZ77_11345 ENOG4107SCK Monooxygenase ELZ77_11360 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ELZ77_11400 ENOG4105DFD Na H antiporter ELZ77_11405 ENOG4105C87 Aminotransferase class I and II ELZ77_11430 ENOG4105XXV Acid-resistance protein ELZ77_11450 ENOG4108Z9K Osmotically inducible protein ELZ77_11455 ENOG4105TPS biofilm-dependent modulation protein ELZ77_11470 ENOG4105DQ4 alcohol dehydrogenase ELZ77_11475 ENOG4108MG3 formate dehydrogenase ELZ77_11480 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ELZ77_11520 ENOG4107QND Nitrite extrusion protein ELZ77_11530 ENOG4108IUE nitrate reductase beta subunit ELZ77_11535 ENOG4108NZN Respiratory nitrate reductase 2 delta chain ELZ77_11540 ENOG4105D0D Nitrate reductase 2, gamma subunit ELZ77_11550 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase ELZ77_11565 ENOG4105C85 amino acid ELZ77_11570 ENOG4105SUV lipoprotein YgdR ELZ77_11575 ENOG4108NS2 receptor ELZ77_11580 ENOG4105CHB tonB-dependent Receptor ELZ77_11585 ENOG4108WYP Transcriptional regulator ELZ77_11590 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ELZ77_11595 ENOG4108Z7F N-acetyltransferase ELZ77_11600 ENOG4108T9Y Inner membrane protein ydcZ ELZ77_11605 ENOG4105R71 cytoplasmic protein ELZ77_11625 ENOG410654E Membrane ELZ77_11640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ELZ77_11645 ENOG4108UQS dipeptidase ELZ77_11665 ENOG4105RR0 Protein of unknown function (DUF2554) ELZ77_11675 ENOG4108JCI Transcriptional regulator ELZ77_11680 ENOG4105DKK Benzoate ELZ77_11685 ENOG4108KKZ (LipO)protein ELZ77_11690 ENOG41088CC tellurite resistance protein tehB ELZ77_11695 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein ELZ77_11700 ENOG4107WE3 acetyltransferase YdcK ELZ77_11705 ENOG4108Z9I -acetyltransferase ELZ77_11710 ENOG4105CN9 Peptidase m42 family protein ELZ77_11715 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) ELZ77_11720 ENOG4105DT3 PTS system, galactitol-specific IIc component ELZ77_11725 ENOG4106P19 photosystem i assembly btpa ELZ77_11730 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) ELZ77_11735 ENOG4108RK0 3-epimerase ELZ77_11740 ENOG4108PQ7 sgc region transcriptional regulator ELZ77_11755 ENOG4108YYC ycei family ELZ77_11765 ENOG4105EBR Carboxylesterase ELZ77_11770 ENOG4105E32 cytoplasmic protein ELZ77_11775 ENOG4105DDW LysR family Transcriptional regulator ELZ77_11780 ENOG4105C8Q Methyl-accepting chemotaxis ELZ77_11810 ENOG4107ZUJ lipid metabolic process ELZ77_11825 ENOG4105E5Q amino acid AbC transporter ELZ77_11835 ENOG4105E5Q amino acid AbC transporter ELZ77_11845 ENOG4108WF3 methyltransferase ELZ77_11850 ENOG4105CPW cytochrome b561 ELZ77_11855 ENOG4107DB1 DUF218 domain ELZ77_11860 ENOG4105CQ7 ATP-dependent helicase ELZ77_11875 ENOG4105WXT Conserved Protein ELZ77_11880 ENOG410689M (LipO)protein ELZ77_11890 ENOG4105C5I Dehydrogenase ELZ77_11895 ENOG41090X5 Heat shock protein hslJ ELZ77_11910 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) ELZ77_11915 ENOG4108RW8 Universal stress protein F ELZ77_11920 ENOG410814C multidrug resistance protein ELZ77_11940 ENOG4105C1J atp-dependent rna helicase ELZ77_11955 ENOG4105C8Q Methyl-accepting chemotaxis ELZ77_11960 ENOG4108DG9 Smr protein MutS2 ELZ77_11965 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ELZ77_11975 ENOG4105Q9Y Universal stress protein ELZ77_11980 ENOG4105S5I Membrane ELZ77_11985 ENOG4105D64 Mechanosensitive ion channel ELZ77_12005 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ELZ77_12030 ENOG4106PHM regulatory protein ELZ77_12045 ENOG4108XFH Transcriptional regulator ELZ77_12050 ENOG4105F6U Short-chain dehydrogenase reductase Sdr ELZ77_12055 ENOG4105CV8 reductase ELZ77_12060 ENOG4105HEI LysR family (Transcriptional regulator ELZ77_12070 ENOG4107QSI ABC, transporter ELZ77_12075 ENOG4105KXI murein peptide amidase A ELZ77_12085 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ELZ77_12090 ENOG4108JU8 Transcriptional regulator ELZ77_12100 ENOG4105CM6 amino acid regulated cytosolic protein ELZ77_12105 ENOG4105K8Z Phage shock protein ELZ77_12110 ENOG4105NNG Peripheral inner membrane phage-shock protein ELZ77_12115 ENOG4105FM1 phage shock protein C ELZ77_12120 ENOG4105YYT phage shock protein B ELZ77_12125 ENOG41087YS Phage shock protein A ELZ77_12130 ENOG4105E51 psp operon transcriptional activator ELZ77_12135 ENOG4108J59 Extracellular solute-binding protein, family 5 ELZ77_12140 ENOG4108I5W peptide transport system, permease protein ELZ77_12195 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ELZ77_12200 ENOG4108JQ2 peptide transport system atp-binding protein ELZ77_12225 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ELZ77_12240 ENOG4105BZU Histidine kinase ELZ77_12250 ENOG4105N2W Transcriptional regulator ELZ77_12255 ENOG41061RM osmotically inducible lipoprotein ELZ77_12260 ENOG4108ZJT translation initiation factor, Sui1 ELZ77_12270 ENOG4105CFV Tetratricopeptide repeat protein ELZ77_12275 ENOG4105Q4A inner membrane protein yciS ELZ77_12280 ENOG4105EYK Phosphatidylglycerophosphatase B ELZ77_12290 ENOG4107QM5 aconitate hydratase ELZ77_12310 ENOG4107R11 Transcriptional regulator ELZ77_12315 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ELZ77_12320 ENOG4105RKX Protein of unknown function (DUF2498) ELZ77_12330 ENOG4105UBK short-chain dehydrogenase reductase ELZ77_12335 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase ELZ77_12340 ENOG4105FE9 pseudouridine synthase ELZ77_12345 ENOG4107RTD sua5 ycio yrdc ywlc family protein ELZ77_12350 ENOG4105DB7 PHP domain protein ELZ77_12360 ENOG4105CRQ synthase (Component I) ELZ77_12365 ENOG4108EFP Anthranilate synthase component II ELZ77_12390 ENOG4108Z9Z response to DNA damage stimulus ELZ77_12395 ENOG4108N8X transition metal ion binding ELZ77_12400 ENOG4105WEF catalase ELZ77_12405 ENOG4105EIF outer membrane protein W ELZ77_12410 ENOG4105PI0 Ferredoxin ELZ77_12425 ENOG4105NAU thioesterase Superfamily protein ELZ77_12435 ENOG4105K9H YciI-like protein ELZ77_12455 ENOG4105EYW Ion transport protein ELZ77_12460 ENOG4108JQ7 (ABC) transporter ELZ77_12465 ENOG4105C3U ABC transporter ELZ77_12470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ELZ77_12475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ELZ77_12480 ENOG4107QSI ABC, transporter ELZ77_12490 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ELZ77_12495 ENOG4108EKI Dehydrogenase ELZ77_12510 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ELZ77_12515 ENOG4105I93 response regulator ELZ77_12520 ENOG4105D78 K07001 NTE family protein ELZ77_12530 ENOG4105CIY formyltetrahydrofolate deformylase ELZ77_12560 ENOG41076YT nitrate reductase, gamma subunit ELZ77_12565 ENOG4105R3A Nitrate reductase ELZ77_12570 ENOG4108IUE nitrate reductase beta subunit ELZ77_12575 ENOG4105CRU nitrate reductase, alpha subunit ELZ77_12580 ENOG4105DQQ Major facilitator superfamily MFS_1 ELZ77_12595 ENOG4105WH1 Two component transcriptional regulator luxr family ELZ77_12600 ENOG4105ID0 Putative invasin ELZ77_12605 ENOG41090EX DsrE family ELZ77_12610 ENOG4105WS7 Cation transport regulator ELZ77_12615 ENOG4105EWV Sodium calcium exchanger membrane region ELZ77_12625 ENOG41063JG Transcriptional regulator ELZ77_12630 ENOG4108YY7 Invasion gene expression up-regulator SirB ELZ77_12660 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ELZ77_12665 ENOG4105CHH sulfate transporter ELZ77_12670 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria ELZ77_12680 ENOG4105C3G gtp-binding protein ELZ77_12690 ENOG4105E3S small subunit ELZ77_12705 ENOG4108USZ hydrogenase ELZ77_12710 ENOG4108VXY Hydrogenase-1 operon protein HyaE ELZ77_12715 ENOG4105MVP hydrogenase-1 operon protein HyaF ELZ77_12720 ENOG4105C4M (Ubiquinol oxidase) subunit I ELZ77_12725 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ELZ77_12735 ENOG4105D82 Glutamate dehydrogenase ELZ77_12750 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) ELZ77_12760 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ELZ77_12770 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ELZ77_12780 ENOG4105ED1 spovr family ELZ77_12805 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation ELZ77_12835 ENOG4107QMS site-determining protein ELZ77_12845 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ELZ77_12850 ENOG4105CEY Amp-dependent synthetase and ligase ELZ77_12855 ENOG4105Y4Z Outer Membrane Lipoprotein ELZ77_12860 ENOG41072GX Peptidase M22 Glycoprotease ELZ77_12865 ENOG4105DVT helicase ELZ77_12870 ENOG4105M4H endoribonuclease L-psp ELZ77_12880 ENOG4105CRQ synthase (Component I) ELZ77_12890 ENOG4105EJQ L-serine dehydratase ELZ77_12895 ENOG4107XTP (EAL) domain protein ELZ77_12900 ENOG4105EE5 Membrane protein terC ELZ77_12905 ENOG4108EQA pts system ELZ77_12910 ENOG4105ETZ PTS System ELZ77_12915 ENOG4105F3R pts system mannose fructose sorbose family iid ELZ77_12930 ENOG4105DHI Methyltransferase ELZ77_12935 ENOG4105CJN penicillin-binding protein ELZ77_12940 ENOG4105VEQ Cold shock protein ELZ77_12945 ENOG410610J Protein of unknown function (DUF2627) ELZ77_12950 ENOG4105Q3Y exported protein ELZ77_12965 ENOG4105J4Q Transcriptional regulator ELZ77_12970 ENOG4105C0R drug resistance transporter emrb qaca subfamily ELZ77_12980 ENOG4105CN1 protease ELZ77_12990 ENOG4108ZGC gaf domain protein ELZ77_12995 ENOG4105H2K paraquat-inducible protein a ELZ77_13000 ENOG4105DY2 Paraquat-inducible protein b ELZ77_13010 ENOG4105WT8 Protein of unknown function (DUF1480) ELZ77_13015 ENOG4105UVW uncharacterized protein yebW ELZ77_13020 ENOG4108R1E Serine threonine protein phosphatase 1 ELZ77_13035 ENOG41064WM Uncharacterized protein YcgX ELZ77_13085 ENOG4105DWP Membrane ELZ77_13105 ENOG4105EUZ Beta-lactamase domain protein ELZ77_13175 ENOG4105UZW Tail fiber assembly protein ELZ77_13190 ENOG4105NKT exported protein ELZ77_13195 ENOG4108PNC copper resistance ELZ77_13200 ENOG4105FXM Copper resistance protein ELZ77_13205 ENOG4105MPK DNA polymerase III subunit theta ELZ77_13210 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ELZ77_13215 ENOG4105UMD exodeoxyribonuclease X ELZ77_13220 ENOG4105CUG Oligopeptidase b ELZ77_13225 ENOG4108Q2J Inner membrane protein YebE ELZ77_13235 ENOG4105X2V dna damage-inducible protein ELZ77_13245 ENOG4108UHU Aldolase ELZ77_13250 ENOG4105C01 Dihydroxy-acid dehydratase ELZ77_13255 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ELZ77_13265 ENOG4106KNT transcriptional regulator ELZ77_13270 ENOG4105CA9 Pyruvate kinase ELZ77_13275 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ELZ77_13280 ENOG4105DR5 peptidase ELZ77_13285 ENOG4105NXV High-affinity zinc uptake system protein ELZ77_13295 ENOG4105FAV ABC, transporter ELZ77_13320 ENOG4107S01 Repressor protein MetJ ELZ77_13340 ENOG4108TIT dATP pyrophosphohydrolase ELZ77_13350 ENOG4105D3W isochorismatase ELZ77_13355 ENOG41081XQ Conserved Protein ELZ77_13360 ENOG4105WJG Glutathione ELZ77_13380 ENOG4106ZCM YecM protein ELZ77_13400 ENOG4105IRD Flagellar protein FlhE ELZ77_13405 ENOG4105D7B Flagellar biosynthesis protein flha ELZ77_13410 ENOG4105D00 flagellar biosynthetic protein flhB ELZ77_13420 ENOG4108VYJ response regulator receiver protein ELZ77_13435 ENOG4105C8Q Methyl-accepting chemotaxis ELZ77_13440 ENOG4108V3W Chemotaxis protein, CheW ELZ77_13445 ENOG4105CBS Chea signal transduction histidine kinase ELZ77_13455 ENOG4107RD7 Flagellar Motor Protein, MotA ELZ77_13460 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region ELZ77_13465 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) ELZ77_13475 ENOG4108VA4 Universal stress protein ELZ77_13485 ENOG4108K4C ec 3.1.3.12 ELZ77_13500 ENOG4108UEC Ferritin-like protein ELZ77_13505 ENOG4105P23 (LipO)protein ELZ77_13510 ENOG41090A1 ferritin ELZ77_13515 ENOG4105VVZ metal-binding protein ELZ77_13520 ENOG4105E0U tyrosine-specific transport protein ELZ77_13525 ENOG4106RHG Yeca family ELZ77_13570 ENOG4105WH1 Two component transcriptional regulator luxr family ELZ77_13575 ENOG4105XVG cytoplasmic protein ELZ77_13580 ENOG4105VJY transcriptional regulator ELZ77_13590 ENOG4105E5Q amino acid AbC transporter ELZ77_13600 ENOG4105EAB amino acid AbC transporter ELZ77_13605 ENOG4108M9K flagella biosynthesis protein FliZ ELZ77_13610 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ELZ77_13615 ENOG4108C80 FliB family ELZ77_13620 ENOG4105I03 Flagellin ELZ77_13625 ENOG4105DTS flagellar hook-associated ELZ77_13630 ENOG4105MQ3 flagellar protein FliS ELZ77_13640 ENOG4105E5K Alpha-amylase ELZ77_13650 ENOG41066VF YeeE YedE family protein ELZ77_13655 ENOG4105KSU Redox protein ELZ77_13670 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ELZ77_13675 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ELZ77_13680 ENOG41090PJ Flagellar assembly protein ELZ77_13690 ENOG4105GSA Flagellar export protein flij ELZ77_13695 ENOG4105WF4 Flagellar hook-length control protein ELZ77_13700 ENOG4107ZI8 flagellar basal body-associated protein flil ELZ77_13705 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ELZ77_13710 ENOG4105DD5 Flagellar motor switch protein ELZ77_13715 ENOG4105K0P flagellar biosynthesis protein ELZ77_13720 ENOG4105CN7 Flagellar biosynthetic protein FliP ELZ77_13725 ENOG4105VS8 Flagellar biosynthetic protein fliq ELZ77_13730 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ELZ77_13735 ENOG4107TKS colanic acid capsular biosynthesis activation protein A ELZ77_13745 ENOG4105YX3 cellular response to acidity ELZ77_13760 ENOG4105VNZ cytoplasmic protein ELZ77_13775 ENOG41090BB DNA mismatch endonuclease (vsr) ELZ77_13780 ENOG4105DVF Cytosine-specific methyltransferase ELZ77_13785 ENOG4105EST Metal Dependent Phosphohydrolase ELZ77_13790 ENOG4105Y0K Inner membrane protein YedR ELZ77_13795 ENOG4105FCK Membrane ELZ77_13820 ENOG410600K aminopeptidase ELZ77_13830 ENOG4105CNA YD repeat protein ELZ77_13870 ENOG4105CS6 Rhs element vgr protein ELZ77_13875 ENOG4108WC9 type VI secretion system effector, hcp1 family ELZ77_13930 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ELZ77_13955 ENOG4105GMB type VI secretion system effector, hcp1 family ELZ77_13980 ENOG4107RJ5 oxidoreductase ELZ77_13985 ENOG4105JHE Major Facilitator Superfamily ELZ77_13990 ENOG4108QGT oligogalacturonate-specific porin ELZ77_14000 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) ELZ77_14005 ENOG4107RJ1 sodium solute ELZ77_14010 ENOG4105QEK Transcriptional regulator ELZ77_14015 ENOG4105D5M phosphate starvation-inducible protein ELZ77_14040 ENOG4108R86 Transcriptional regulator ELZ77_14045 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 ELZ77_14055 ENOG4105XH3 ELZ77_14060 ENOG4105D6F Phosphatase ELZ77_14065 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ELZ77_14070 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ELZ77_14075 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ELZ77_14140 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase ELZ77_14155 ENOG4108V8F Transcriptional regulator, MarR family ELZ77_14160 ENOG4105EFA 4-hydroxyphenylacetate ELZ77_14165 ENOG4107UWN reductase ELZ77_14175 ENOG4105VT2 5-hydroxyisourate hydrolase ELZ77_14180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ELZ77_14185 ENOG4107ZY3 Histidine kinase ELZ77_14200 ENOG4106YSC ELZ77_14205 ENOG4108N4M Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell ELZ77_14220 ENOG41084BJ Pentapeptide repeat protein ELZ77_14235 ENOG4108MN8 Membrane ELZ77_14245 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ELZ77_14255 ENOG4108V1U phospholipid-binding protein ELZ77_14270 ENOG4105K4P CoA-binding domain protein ELZ77_14285 ENOG41088T4 Helicase IV ELZ77_14290 ENOG410901E Membrane ELZ77_14295 ENOG4105EM2 membrane ELZ77_14300 ENOG4108RZ1 DNA transformation protein ELZ77_14310 ENOG4105UYK outer membrane protein a ELZ77_14320 ENOG4105DAN ATP-dependent protease ELZ77_14330 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) ELZ77_14335 ENOG4108Q2G (LipO)protein ELZ77_14340 ENOG4105DY2 Paraquat-inducible protein b ELZ77_14345 ENOG4105F1S paraquat-inducible protein a ELZ77_14350 ENOG4105C5H ABC transporter ELZ77_14360 ENOG4105QVC MOSC domain-containing protein ELZ77_14365 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ELZ77_14375 ENOG4105CD8 aminopeptidase N ELZ77_14385 ENOG4105C5S asparaginyl-tRNA synthetase ELZ77_14390 ENOG4105FCK Membrane ELZ77_14395 ENOG4105CGF Aromatic amino acid aminotransferase ELZ77_14400 ENOG4105C5X domain protein ELZ77_14405 ENOG4105EAQ (twin-arginine translocation) pathway signal ELZ77_14410 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ELZ77_14420 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ELZ77_14430 ENOG4106371 Methyltransferase ELZ77_14435 ENOG4107S90 membrAne ELZ77_14440 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups ELZ77_14455 ENOG4105T0Z Conserved Protein ELZ77_14470 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ELZ77_14475 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ELZ77_14480 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ELZ77_14490 ENOG4108K0D peptidase, M48 ELZ77_14505 ENOG4107VMU Membrane ELZ77_14510 ENOG4105DDY UPF0142 protein ycaO ELZ77_14515 ENOG4105TMB Formate nitrite transporter ELZ77_14520 ENOG4105C6N Formate acetyltransferase ELZ77_14525 ENOG4105GUS ELZ77_14535 ENOG4105F1A Pyruvate formate-lyase ELZ77_14540 ENOG4105E5D amino acid ELZ77_14550 ENOG4107KGK dmso reductase anchor subunit ELZ77_14555 ENOG4105QAX Iron-sulfur ELZ77_14560 ENOG4107QY8 reductase ELZ77_14570 ENOG4105D1H recombination factor protein RarA ELZ77_14585 ENOG4105EW9 transcriptional regulator AsnC family ELZ77_14590 ENOG4105C3M thioredoxin reductase ELZ77_14595 ENOG4108JJ9 ABC, transporter ELZ77_14600 ENOG4108JJ8 (ABC) transporter ELZ77_14615 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ELZ77_14625 ENOG4105EUB pirin domain protein ELZ77_14630 ENOG4105CHJ isochorismatase hydrolase ELZ77_14670 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ELZ77_14680 ENOG4105VEQ Cold shock protein ELZ77_14685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ELZ77_14690 ENOG4105DJY efflux transporter, rnd family, mfp subunit ELZ77_14695 ENOG4108MJ5 VirK protein ELZ77_14700 ENOG4105CPB ATP-dependent endonuclease of the OLD family ELZ77_14705 ENOG4105DWU Membrane ELZ77_14715 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ELZ77_14720 ENOG4105C7K acetolactate synthase ELZ77_14725 ENOG4105C5W Aldolase ELZ77_14730 ENOG4105CGD Nad-dependent epimerase dehydratase ELZ77_14735 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ELZ77_14740 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ELZ77_14750 ENOG41064MM (LipO)protein ELZ77_14755 ENOG4105E5Z arginine transporter ATP-binding subunit ELZ77_14760 ENOG4106PMH Extracellular solute-binding protein family 3 ELZ77_14765 ENOG4105GBT ABC transporter ELZ77_14770 ENOG4105DMR ABC, transporter ELZ77_14775 ENOG4106TNF Periplasmic binding protein ELZ77_14800 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) ELZ77_14805 ENOG4105RBQ inner membrane protein ybjO ELZ77_14810 ENOG4105D38 putrescine abc transporter ELZ77_14815 ENOG4105F38 ABC transporter, permease ELZ77_14820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ELZ77_14825 ENOG4107RUE extracellular solute-binding protein family 1 ELZ77_14830 ENOG4108RMJ sensory transduction regulator ELZ77_14840 ENOG4108DBC nitroreductase ELZ77_14845 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress ELZ77_14850 ENOG41090BQ Glutaredoxin ELZ77_14855 ENOG4105GWF inner membrane protein YbjM ELZ77_14865 ENOG4108RFG Tetr family transcriptional regulator ELZ77_14870 ENOG4106UW1 Major Facilitator superfamily ELZ77_14875 ENOG4108HCJ Hydrolase ELZ77_14880 ENOG4107QF7 multi-drug ELZ77_14885 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ELZ77_14890 ENOG4107FB0 transcriptional regulator DeoR family ELZ77_14895 ENOG4105DZ1 carboxypeptidase ELZ77_14900 ENOG4108TGY Glutathione S-transferase ELZ77_14905 ENOG4105D8V Glucose sorbosone dehydrogenase ELZ77_14910 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway ELZ77_14930 ENOG4105DEF Extracellular solute-binding protein, family 5 ELZ77_14935 ENOG4108JQ6 ABC transporter ELZ77_14945 ENOG4105CVM Molybdenum cofactor synthesis domain protein ELZ77_14950 ENOG4105D06 uba thif-type nad fad binding protein ELZ77_14955 ENOG4105F1A Pyruvate formate-lyase ELZ77_14960 ENOG4105C6N Formate acetyltransferase ELZ77_14970 ENOG41072TH Protein of unknown function (DUF1479) ELZ77_14975 ENOG4105C5H ABC transporter ELZ77_14980 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ELZ77_14985 ENOG4105F4P )-transporter ELZ77_14990 ENOG4105KST dependent repressor ELZ77_15000 ENOG4108I6E Sulfatase ELZ77_15005 ENOG4108T1M outer membrane protein x ELZ77_15020 ENOG4107R0W ABC transporter ELZ77_15025 ENOG4105E5Q amino acid AbC transporter ELZ77_15030 ENOG4105CDA abc transporter atp-binding protein ELZ77_15045 ENOG4105KSC Transcriptional regulator, TraR DksA family ELZ77_15050 ENOG4105VR4 UPF0379 protein ybiJ ELZ77_15060 ENOG4105DVT helicase ELZ77_15065 ENOG4105C1J atp-dependent rna helicase ELZ77_15070 ENOG4107MVR Transcriptional regulator ELZ77_15080 ENOG4105CJ1 ABC, transporter ELZ77_15085 ENOG4107QWP ABC-2 type transporter ELZ77_15095 ENOG4105I9U inner membrane protein ybhQ ELZ77_15100 ENOG4105X23 Endonuclease Exonuclease phosphatase ELZ77_15105 ENOG4105DZQ phospholipase D Transphosphatidylase ELZ77_15110 ENOG4107UXM Membrane ELZ77_15130 ENOG4105HFZ Membrane ELZ77_15135 ENOG4108ZAF Molybdopterin ELZ77_15140 ENOG4105M00 molybdopterin converting factor, subunit 1 ELZ77_15150 ENOG4108RIR Molybdenum cofactor biosynthesis protein ELZ77_15160 ENOG4105CHW UPF0052 protein ELZ77_15185 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ELZ77_15205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ELZ77_15210 ENOG4108V1U phospholipid-binding protein ELZ77_15240 ENOG4105NBR Pectinesterase ELZ77_15250 ENOG4108K4B hydrolase ELZ77_15260 ENOG4105E0C molybdate abc transporter ELZ77_15265 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ELZ77_15270 ENOG410680R Protein of unknown function (DUF2592) ELZ77_15275 ENOG4105F4R Transcriptional regulator mode ELZ77_15280 ENOG4105DKW ABC transporter ELZ77_15290 ENOG4105CMR udp-glucose 4-epimerase ELZ77_15305 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ELZ77_15320 ENOG4105E0A ABC, transporter ELZ77_15325 ENOG4105EHG Permease protein ELZ77_15330 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ELZ77_15340 ENOG4107QSA Oxaloacetate decarboxylase ELZ77_15350 ENOG4107QWE )-transporter ELZ77_15360 ENOG4105C5Q Transcriptional regulator ELZ77_15365 ENOG4106DSS Tartrate dehydratase subunit alpha ELZ77_15370 ENOG4107GFK fumarate ELZ77_15375 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ELZ77_15380 ENOG4105JND homeobox protein ELZ77_15385 ENOG4105PGM cation diffusion facilitator family transporter ELZ77_15390 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ELZ77_15430 ENOG4105UFD tol-pal system protein YbgF ELZ77_15435 ENOG4105KCK Peptidoglycan-associated lipoprotein ELZ77_15450 ENOG4105M8F Biopolymer transport protein exbD tolR ELZ77_15455 ENOG4105E02 MotA TolQ exbB proton channel ELZ77_15460 ENOG4107YD3 Thioesterase ELZ77_15465 ENOG4105KJB cyd operon protein YbgE ELZ77_15475 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ELZ77_15480 ENOG4105C4M (Ubiquinol oxidase) subunit I ELZ77_15490 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ELZ77_15500 ENOG4105C7S Dehydrogenase ELZ77_15505 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ELZ77_15510 ENOG4105E33 succinate dehydrogenase ELZ77_15515 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ELZ77_15520 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ELZ77_15525 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ELZ77_15535 ENOG4108KK1 membrane protein AbrB duplication ELZ77_15560 ENOG410602S Transferase ELZ77_15600 ENOG4108W9T type 1 fimbriae regulatory protein ELZ77_15615 ENOG4107R7A Allophanate hydrolase subunit 2 ELZ77_15620 ENOG4105P4J Allophanate hydrolase, subunit 1 ELZ77_15625 ENOG4107QNR UPF0135 protein ELZ77_15640 ENOG4105CVP deoxyribo-dipyrimidine photolyase ELZ77_15650 ENOG4105GMB type VI secretion system effector, hcp1 family ELZ77_15680 ENOG4105C08 Histidine kinase ELZ77_15685 ENOG4105EEX Two component transcriptional regulator (Winged helix family ELZ77_15695 ENOG4105CXN decarboxylase ELZ77_15700 ENOG4105D5Q Arginine ornithine antiporter ELZ77_15710 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ELZ77_15715 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ELZ77_15720 ENOG4105EV9 Alpha Beta Hydrolase ELZ77_15725 ENOG4105NNH LexA regulated protein ELZ77_15730 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ELZ77_15735 ENOG41090R7 Ferric uptake ELZ77_15740 ENOG4106P55 Transcriptional regulator ELZ77_15745 ENOG4107EFR Flavocytochrome c ELZ77_15755 ENOG4105CSH Transporter ELZ77_15760 ENOG4105GX6 (LipO)protein ELZ77_15765 ENOG4105J5J Outer membrane porin ELZ77_15775 ENOG4105CI1 PTS System ELZ77_15785 ENOG4105CE4 GlcNAc 6-P deacetylase ELZ77_15790 ENOG4105E2R ROK family ELZ77_15795 ENOG4105D4U had-superfamily hydrolase, subfamily iia ELZ77_15800 ENOG4105CAQ asparagine synthetase ELZ77_15835 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ELZ77_15845 ENOG4105C9A Phoh family ELZ77_15855 ENOG4108JU5 Magnesium and cobalt efflux protein ELZ77_15860 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ELZ77_15865 ENOG4107RP9 extracellular solute-binding protein, family 3 ELZ77_15870 ENOG4105EAD ABC transporter ELZ77_15880 ENOG4105CDA abc transporter atp-binding protein ELZ77_15895 ENOG4107PAI alpha helical protein ELZ77_15900 ENOG4108JUB Transcriptional regulator ELZ77_15905 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) ELZ77_15930 ENOG4105DJF DNA polymerase III, delta' subunit ELZ77_15935 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ELZ77_15940 ENOG4107QZB decarboxylase ELZ77_15945 ENOG4108TGR phosphatase ELZ77_15950 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ELZ77_15960 ENOG4105CJN penicillin-binding protein ELZ77_15975 ENOG4105DZ1 carboxypeptidase ELZ77_15980 ENOG4108Z43 UPF0250 protein ELZ77_15990 ENOG41064T2 transcriptional regulator, lysR family ELZ77_16005 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ELZ77_16015 ENOG4105VEQ Cold shock protein ELZ77_16025 ENOG4105CEE C4-dicarboxylate transporter ELZ77_16030 ENOG4106YYS transcriptional regulatory protein ELZ77_16040 ENOG4105DUA (citrate (pro-3S)-lyase ligase ELZ77_16045 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ELZ77_16050 ENOG4105CI0 Citrate lyase ELZ77_16055 ENOG4105CHY citrate lyase, alpha ELZ77_16060 ENOG4105YGP holo-ACP synthase CitX ELZ77_16070 ENOG4107QPK )-transporter ELZ77_16075 ENOG4105KTS ribonuclease ELZ77_16080 ENOG4105NXH GreA GreB family elongation factor ELZ77_16085 ENOG4105E2A Dehydrogenase ELZ77_16090 ENOG4108U51 Universal stress protein ELZ77_16100 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ELZ77_16105 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ELZ77_16115 ENOG4108JU3 Alkyl hydroperoxide reductase ELZ77_16120 ENOG4105D3R alkyl hydroperoxide reductase ELZ77_16125 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase ELZ77_16135 ENOG4105DQS Transcriptional regulator ELZ77_16140 ENOG4105BZV Phosphoadenosine phosphosulfate reductase ELZ77_16145 ENOG4105GTN ParB Domain Protein Nuclease ELZ77_16150 ENOG4105CHM Aminotransferase ELZ77_16160 ENOG4105VCD cytoplasmic protein ELZ77_16165 ENOG4105D22 carbon starvation protein ELZ77_16175 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ELZ77_16180 ENOG4105WQI isochorismatase ELZ77_16185 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ELZ77_16190 ENOG4105E4F Isochorismate synthase ELZ77_16195 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein ELZ77_16200 ENOG4105E8G Major facilitator Superfamily ELZ77_16205 ENOG4105DQ5 transport system permease protein ELZ77_16210 ENOG4105TVJ transport system, permease ELZ77_16215 ENOG4105E0A ABC, transporter ELZ77_16220 ENOG4108QY5 Ferric enterobactin transport protein ELZ77_16225 ENOG4105C0W non-ribosomal peptide synthetase ELZ77_16230 ENOG41085A6 mbth domain-containing protein ELZ77_16235 ENOG4105E93 esterase ELZ77_16240 ENOG4107RNH Outer membrane receptor FepA ELZ77_16245 ENOG4108TSE Transferase ELZ77_16250 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) ELZ77_16255 ENOG4105WQ6 Membrane ELZ77_16260 ENOG4105HFT AraC family transcriptional regulator ELZ77_16265 ENOG41067SE Tetr family transcriptional regulator ELZ77_16270 ENOG4105MSB protein, conserved in bacteria ELZ77_16275 ENOG4108RCM Nitroreductase ELZ77_16285 ENOG4105CUY Mechanosensitive ion channel ELZ77_16290 ENOG4105C85 amino acid ELZ77_16300 ENOG4108KBJ Inner membrane protein YkgB ELZ77_16305 ENOG41066GK UPF0379 protein ykgI ELZ77_16310 ENOG4107QN2 dihydrolipoyl dehydrogenase ELZ77_16315 ENOG4108K01 transcriptional regulator ELZ77_16330 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) ELZ77_16335 ENOG4105CKK Glycosyl transferase, family 2 ELZ77_16350 ENOG4108KU3 Integrase ELZ77_16365 ENOG4106KCD HTH_LUXR ELZ77_16375 ENOG4106721 fimbriae Y protein ELZ77_16380 ENOG4108Q9V regulatoR ELZ77_16385 ENOG4108ZI2 Fimbrial protein ELZ77_16390 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) ELZ77_16400 ENOG4108AF8 Chaperone ELZ77_16410 ENOG4108WDE Fimbrial protein ELZ77_16425 ENOG4105WQ3 Rna-binding protein ELZ77_16430 ENOG4105S2T inner membrane protein YbcI ELZ77_16440 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ELZ77_16450 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ELZ77_16455 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ELZ77_16465 ENOG4105G5A Protein of unknown function (DUF2877) ELZ77_16470 ENOG4107REC cytoplasmic protein ELZ77_16475 ENOG4107R1Q Membrane protein FdrA ELZ77_16480 ENOG4105DG4 malate L-lactate dehydrogenase ELZ77_16485 ENOG4105CE7 Amidase, hydantoinase carbamoylase family ELZ77_16490 ENOG4105S0E allantoin catabolism protein ELZ77_16495 ENOG4105BZW Glycerate kinase ELZ77_16500 ENOG4105DTE Xanthine uracil vitamin C permease ELZ77_16510 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ELZ77_16520 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ELZ77_16525 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ELZ77_16530 ENOG41060W2 glyoxylate carboligase ELZ77_16550 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) ELZ77_16555 ENOG4108UMI ABC transporter, permease ELZ77_16560 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ELZ77_16565 ENOG4105D01 (LipO)protein ELZ77_16575 ENOG4105CV6 ABC transporter, permease ELZ77_16580 ENOG4108I0Y (ABC) transporter ELZ77_16585 ENOG4108UJV acyl-CoA thioesterase i ELZ77_16590 ENOG4105E1F short-chain dehydrogenase reductase ELZ77_16595 ENOG4107QR8 Thioredoxin ELZ77_16600 ENOG4105C4B ABC transporter, permease ELZ77_16605 ENOG41083J0 (ABC) transporter ELZ77_16610 ENOG4107QX8 SPFH domain, Band 7 family protein ELZ77_16620 ENOG4108Z6Z Transcriptional regulator ELZ77_16625 ENOG4105C59 p-type ATPase ELZ77_16635 ENOG4105MBR gumn family ELZ77_16640 ENOG4108Z66 YbaK ebsC protein ELZ77_16645 ENOG4105CGH 5'-nucleotidase ELZ77_16650 ENOG4105EU0 Major facilitator Superfamily ELZ77_16660 ENOG4107RE1 Inosine-guanosine kinase ELZ77_16665 ENOG4105F2M alpha beta hydrolase fold-3 domain protein ELZ77_16705 ENOG4107QMP dna polymerase iii subunits gamma and tau ELZ77_16715 ENOG4105WD1 Membrane ELZ77_16720 ENOG4108URS primosomal replication protein n'' ELZ77_16725 ENOG4106428 Protein of unknown function (DUF2496) ELZ77_16730 ENOG4105DNE Transposase ELZ77_16735 ENOG4105EGS Mechanosensitive ion channel ELZ77_16740 ENOG4108IG5 Transcriptional regulator ELZ77_16750 ENOG4105BZS acriflavin resistance protein ELZ77_16755 ENOG4108UKR Biofilm formation regulator YbaJ ELZ77_16765 ENOG4108UW5 maltose o-acetyltransferase ELZ77_16770 ENOG4105GSJ Inner membrane protein ylaC ELZ77_16785 ENOG41066DG (EAL) domain protein ELZ77_16795 ENOG41080UX Methyltransferase ELZ77_16800 ENOG4108MNP Glycoprotein polysaccharide metabolism ELZ77_16805 ENOG4105C29 acyl-CoA thioesterase ELZ77_16810 ENOG4105BZU Histidine kinase ELZ77_16815 ENOG4108YZA Nitrogen regulatory protein pii ELZ77_16820 ENOG4105BZ1 (ABC) transporter ELZ77_16830 ENOG4108XM1 transcriptional regulator AsnC family ELZ77_16845 ENOG4108NFA extracellular solute-binding protein ELZ77_16855 ENOG4108TGP Thioesterase superfamily protein ELZ77_16860 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ELZ77_16865 ENOG4105EIN peptidylprolyl cis-trans isomerase ELZ77_16870 ENOG4105K70 DNA-binding protein ELZ77_16875 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ELZ77_16900 ENOG4105M85 Bola protein ELZ77_16905 ENOG4105IEY (LipO)protein ELZ77_16910 ENOG4105EYM Major Facilitator superfamily ELZ77_16915 ENOG4105E2S oxidase) subunit II ELZ77_16920 ENOG4105BZ9 Cytochrome C oxidase, subunit I ELZ77_16925 ENOG4105CCU oxidase (Subunit III) ELZ77_16950 ENOG4107RDB Major Facilitator ELZ77_16960 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ELZ77_16965 ENOG4107S0N DJ-1 family ELZ77_16970 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ELZ77_16980 ENOG4106S9K Transcriptional regulator ELZ77_16990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ELZ77_17000 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component ELZ77_17015 ENOG4105CTB Polyprenyl synthetase ELZ77_17025 ENOG4105CPC Aldo Keto reductase ELZ77_17030 ENOG4108ZAI phosphatidylglycerophosphatase a ELZ77_17040 ENOG4107YIM Involved in the transcription termination process (By similarity) ELZ77_17050 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ELZ77_17060 ENOG4108KIC (LipO)protein ELZ77_17065 ENOG4105DRB nucleoside-specific channel-forming protein ELZ77_17080 ENOG4105N1F Hnh endonuclease ELZ77_17095 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ELZ77_17105 ENOG4105VIE preprotein translocase, subunit YajC ELZ77_17125 ENOG4105D3R alkyl hydroperoxide reductase ELZ77_17130 ENOG4107R28 alpha amylase, catalytic region ELZ77_17135 ENOG4105C85 amino acid ELZ77_17140 ENOG4105CWM branched-chain amino acid transport system II carrier protein ELZ77_17145 ENOG4105BZU Histidine kinase ELZ77_17150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ELZ77_17155 ENOG4107RH8 nuclease SbcCD subunit D ELZ77_17160 ENOG4105EYH Exonuclease ELZ77_17165 ENOG4105F27 Major Facilitator ELZ77_17170 ENOG4105DKQ ROK family ELZ77_17185 ENOG4105HBA AroM protein ELZ77_17190 ENOG4105SS3 ELZ77_17205 ENOG4105II7 pyrroline-5-carboxylate reductase ELZ77_17210 ENOG4105BZU Histidine kinase ELZ77_17215 ENOG4105VIF phosphate starvation-inducible protein ELZ77_17240 ENOG4105CPF Cell wall formation (By similarity) ELZ77_17245 ENOG4105UNH Membrane ELZ77_17250 ENOG4105FR5 inner membrane protein YaiY ELZ77_17260 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 ELZ77_17270 ENOG4107R6D beta-lactam binding protein AmpH ELZ77_17275 ENOG4108PNB DNA-binding transcriptional regulator ELZ77_17280 ENOG4108NSE outer membrane autotransporter barrel ELZ77_17285 ENOG4105D52 delta-aminolevulinic acid dehydratase ELZ77_17295 ENOG4105DXD 2-methylcitrate dehydratase ELZ77_17300 ENOG4105BZN citrate synthase ELZ77_17305 ENOG4105CR4 methylisocitrate lyase ELZ77_17310 ENOG4108JU7 Transcriptional regulator ELZ77_17315 ENOG4105TDT uncharacterized protein yahO ELZ77_17320 ENOG4105E82 cytochrome subunit of dehydrogenase ELZ77_17340 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ELZ77_17345 ENOG4105C4M (Ubiquinol oxidase) subunit I ELZ77_17355 ENOG4105D8D Type III ELZ77_17360 ENOG4107QMH DNA methylase ELZ77_17365 ENOG4105JHE Major Facilitator Superfamily ELZ77_17395 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ELZ77_17415 ENOG4108T1M outer membrane protein x ELZ77_17430 ENOG4107XTP (EAL) domain protein ELZ77_17445 ENOG4105X0I Fimbrial ELZ77_17450 ENOG4108VEV chaperone ELZ77_17455 ENOG4105CW0 outer membrane usher protein ELZ77_17480 ENOG4105EJC lysr family transcriptional regulator ELZ77_17490 ENOG4105ERH Fumarylacetoacetate hydrolase ELZ77_17495 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ELZ77_17500 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ELZ77_17510 ENOG4105V2F Uncharacterized protein yoac ELZ77_17520 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit ELZ77_17575 ENOG4105VDM plasmid maintenance system antidote protein, xre family ELZ77_17580 ENOG4105NI8 Cytosine-specific methyltransferase ELZ77_17630 ENOG4105CIN aminoacyl-histidine dipeptidase ELZ77_17635 ENOG4108S2Y peptide Chain Release factor ELZ77_17650 ENOG4105F7V ErfK ybiS ycfS ynhG family protein ELZ77_17655 ENOG4105E7A Glutamine amidotransferase ELZ77_17665 ENOG4107QPN acyl-Coa dehydrogenase ELZ77_17670 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ELZ77_17685 ENOG4105T40 surface antigen msp4 family protein ELZ77_17705 ENOG4108XM1 transcriptional regulator AsnC family ELZ77_17750 ENOG4105W7K Transcriptional regulator ELZ77_17815 ENOG4105CS6 Rhs element vgr protein ELZ77_17965 ENOG4108JDX DNA polymerase iii, epsilon subunit ELZ77_17975 ENOG4105D1A Methyltransferase ELZ77_17985 ENOG4105E9H Lytic Murein transglycosylase ELZ77_17990 ENOG4105F2W methyltransferase ELZ77_18000 ENOG4105F27 Major Facilitator ELZ77_18005 ENOG4105HEI LysR family (Transcriptional regulator ELZ77_18010 ENOG4105CV8 reductase ELZ77_18050 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ELZ77_18055 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ELZ77_18060 ENOG4108UMI ABC transporter, permease ELZ77_18065 ENOG4105D01 (LipO)protein ELZ77_18070 ENOG4108R8X outer membrane lipoprotein ELZ77_18075 ENOG4108R96 Methyltransferase, YaeB family ELZ77_18085 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion ELZ77_18090 ENOG4108YZN class I peptide chain release factor ELZ77_18095 ENOG4108VWS Yaeq family ELZ77_18105 ENOG4105M1T rho-binding antiterminator ELZ77_18110 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ELZ77_18115 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ELZ77_18120 ENOG4105CXN decarboxylase ELZ77_18125 ENOG4108M1A Chitin-binding protein ELZ77_18135 ENOG4105C0B DNA polymerase III (alpha subunit) ELZ77_18180 ENOG4105KNE Phosphatidate cytidylyltransferase ELZ77_18215 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ELZ77_18225 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ELZ77_18230 ENOG4105CSH Transporter ELZ77_18240 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ELZ77_18245 ENOG4105C0H protease ELZ77_18260 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ELZ77_18265 ENOG4105EN6 Membrane ELZ77_18285 ENOG4106RDH Protein of unknown function (DUF2544) ELZ77_18295 ENOG4105UGQ Fimbrial ELZ77_18300 ENOG4105NEV Fimbrial ELZ77_18305 ENOG4108FZ9 Chaperone ELZ77_18310 ENOG4106PG1 outer membrane usher protein ELZ77_18325 ENOG4105S6R Iron-hydroxamate transporter permease subunit ELZ77_18330 ENOG4105J76 Periplasmic binding protein ELZ77_18335 ENOG4105E0A ABC, transporter ELZ77_18340 ENOG4105E0K tonB-dependent siderophore receptor ELZ77_18345 ENOG4105BZ4 penicillin-binding protein ELZ77_18355 ENOG4107XID 2'-5' rna ligase ELZ77_18360 ENOG4105PW4 Sugar fermentation stimulation protein homolog ELZ77_18365 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ELZ77_18370 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ELZ77_18375 ENOG4105DJ0 Poly(A) Polymerase ELZ77_18380 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ELZ77_18390 ENOG4108VEV chaperone ELZ77_18395 ENOG4105CW0 outer membrane usher protein ELZ77_18400 ENOG4108XEY fimbrial-like adhesin protein ELZ77_18405 ENOG4105SYG Fimbrial protein ELZ77_18420 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ELZ77_18425 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ELZ77_18435 ENOG4107BJW polysaccharide deacetylase ELZ77_18440 ENOG4108YTN IIa component ELZ77_18445 ENOG4105E3A (ABC) transporter ELZ77_18450 ENOG4105DA5 (ABC) transporter ELZ77_18455 ENOG41077A9 carbonic anhydrase ELZ77_18460 ENOG4108UGV hypoxanthine phosphoribosyltransferase ELZ77_18465 ENOG4105DZG Dehydrogenase ELZ77_18470 ENOG4105E3B Multicopper oxidase ELZ77_18475 ENOG4108ZRK uncharacterized protein yacC ELZ77_18495 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ELZ77_18500 ENOG4107S2N Type III effector Hrp-dependent ELZ77_18505 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) ELZ77_18515 ENOG4107QIJ Aconitate hydratase 2 ELZ77_18535 ENOG4107QN2 dihydrolipoyl dehydrogenase ELZ77_18545 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ELZ77_18550 ENOG41073TP transcriptional regulator ELZ77_18555 ENOG4105C85 amino acid ELZ77_18560 ENOG4105CT4 transporter ELZ77_18565 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) ELZ77_18570 ENOG4106A72 regulatory protein AmpE ELZ77_18580 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ELZ77_18590 ENOG4108ZUW Major pilin subunit ELZ77_18595 ENOG4107QHF type ii secretion system protein e ELZ77_18600 ENOG4105D7Q type ii secretion system ELZ77_18610 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ELZ77_18625 ENOG410642W LysR family Transcriptional regulator ELZ77_18630 ENOG4108FN7 Aldo keto reductase ELZ77_18635 ENOG4105M6F mutator MutT protein ELZ77_18655 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ELZ77_18660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ELZ77_18665 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ELZ77_18670 ENOG4105CPF Cell wall formation (By similarity) ELZ77_18685 ENOG4105CNI cell division protein FtsW ELZ77_18700 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ELZ77_18705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ELZ77_18710 ENOG4105CJN penicillin-binding protein ELZ77_18715 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ELZ77_18730 ENOG4107B7Y DNA-binding transcriptional regulator FruR ELZ77_18735 ENOG4108ZP8 Acetolactate synthase small subunit ELZ77_18740 ENOG4105C7K acetolactate synthase ELZ77_18745 ENOG41064T2 transcriptional regulator, lysR family ELZ77_18770 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ELZ77_18785 ENOG4105DP9 ABC transporter ELZ77_18790 ENOG4106SMU thiamine transporter membrane protein ELZ77_18795 ENOG4107T0D ABC, transporter ELZ77_18800 ENOG4108KF1 Membrane ELZ77_18805 ENOG41063TF transcriptional regulator (AraC ELZ77_18820 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ELZ77_18840 ENOG4105CQ2 DNA polymerase ELZ77_18850 ENOG4105D3G Pseudouridine synthase ELZ77_18860 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ELZ77_18870 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ELZ77_18930 ENOG4105M5B (LipO)protein ELZ77_18935 ENOG4105C54 Major Facilitator superfamily ELZ77_18940 ENOG4105WQV ferredoxin-like protein ELZ77_18970 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ELZ77_18990 ENOG4108XNW Transcriptional activatory protein CaiF ELZ77_18995 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ELZ77_19000 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ELZ77_19025 ENOG4105CHY citrate lyase, alpha ELZ77_19030 ENOG4105CI0 Citrate lyase ELZ77_19040 ENOG4105DUA (citrate (pro-3S)-lyase ligase ELZ77_19050 ENOG4106AFN Lyase and sodium transporter (By similarity) ELZ77_19055 ENOG4107QSA Oxaloacetate decarboxylase ELZ77_19065 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ELZ77_19070 ENOG4106YYS transcriptional regulatory protein ELZ77_19090 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ELZ77_19105 ENOG4105DTN riboflavin biosynthesis protein ribF ELZ77_19110 ENOG410647N response to DNA damage stimulus ELZ77_19130 ENOG41063Z6 transcriptional regulator, lysR family ELZ77_19155 ENOG4105C4X radical SAM domain protein ELZ77_19160 ENOG41061MV Arylsulfatase ELZ77_19195 ENOG4106PH7 chaperone ELZ77_19210 ENOG4105MHR Fimbrial protein ELZ77_19215 ENOG4105CW0 outer membrane usher protein ELZ77_19220 ENOG4108AF8 Chaperone ELZ77_19280 ENOG4108QUJ UPF0174 protein YaaW ELZ77_19285 ENOG4106HK8 GPR1 FUN34 yaaH family protein ELZ77_19290 ENOG4108RIR Molybdenum cofactor biosynthesis protein ELZ77_19300 ENOG4105BZG amino acid carrier protein ELZ77_19310 ENOG4105D98 threonine synthase ELZ77_19315 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ELZ77_19330 ENOG4106FVC RNA methyltransferase ELZ77_19335 ENOG410759A ELZ77_19340 ENOG41065U4 response regulator ELZ77_19350 ENOG4108PNB DNA-binding transcriptional regulator ELZ77_19360 ENOG4108VCD Chaperone ELZ77_19365 ENOG4105CW0 outer membrane usher protein ELZ77_19380 ENOG4105CT7 inner membrane cred family protein ELZ77_19385 ENOG4105EB3 Histidine kinase ELZ77_19390 ENOG4105E3W Two component transcriptional regulator (Winged helix family ELZ77_19395 ENOG4108RH0 Crea protein ELZ77_19400 ENOG4105UEI Transcriptional Regulator AraC Family ELZ77_19420 ENOG4107SC1 transglycosylase ELZ77_19425 ENOG4105C5H ABC transporter ELZ77_19430 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase ELZ77_19440 ENOG4105EAC phosphoserine phosphatase ELZ77_19450 ENOG41062Z9 Membrane ELZ77_19455 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) ELZ77_19460 ENOG4108UK5 Transposase ELZ77_19485 ENOG4105G0K glycine radical enzyme YjjI family ELZ77_19490 ENOG41076CZ activating enzyme ELZ77_19495 ENOG4105EYA deoxyribonuclease ELZ77_19500 ENOG4108NRW Phospholipase, patatin family ELZ77_19510 ENOG4105K3G Periplasmic Protein ELZ77_19520 ENOG4105PAD Hydrolase ELZ77_19525 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ELZ77_19530 ENOG4108WPU DNA polymerase III subunit psi ELZ77_19545 ENOG4105YBH Protein of unknown function (DUF1435) ELZ77_19550 ENOG4105BZU Histidine kinase ELZ77_19555 ENOG4108819 ferric iron reductase ELZ77_19560 ENOG4108UIN ybak prolyl-trna synthetase associated region ELZ77_19565 ENOG4108T94 DNA-binding transcriptional activator BglJ ELZ77_19570 ENOG4108N8T regulatoR ELZ77_19575 ENOG4105DWK Membrane ELZ77_19590 ENOG4106CVF DNA replication protein ELZ77_19595 ENOG4105RI1 glycoprotein receptor ELZ77_19605 ENOG4105C8Q Methyl-accepting chemotaxis ELZ77_19610 ENOG4105D22 carbon starvation protein ELZ77_19615 ENOG4105VCD cytoplasmic protein ELZ77_19620 ENOG4105CKI cobalamin synthesis protein ELZ77_19625 ENOG41063TF transcriptional regulator (AraC ELZ77_19630 ENOG4105E82 cytochrome subunit of dehydrogenase ELZ77_19655 ENOG4105C26 Dehydrogenase ELZ77_19660 ENOG4105DNE Transposase ELZ77_19665 ENOG41083G8 Multidrug resistance protein MdtM ELZ77_19670 ENOG4106BRA Membrane ELZ77_19685 ENOG41074DU domain protein ELZ77_19690 ENOG4108P2H Inner membrane protein YjiG ELZ77_19695 ENOG4105DYB Isoaspartyl dipeptidase ELZ77_19700 ENOG4107YNJ LysR family Transcriptional regulator ELZ77_19725 ENOG4105C6F GntR Family Transcriptional Regulator ELZ77_19750 ENOG4105KZM cytoplasmic protein ELZ77_19760 ENOG4105YCT UPF0386 protein ELZ77_19765 ENOG4105DTA methyltransferase ELZ77_19800 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ELZ77_19845 ENOG4105DQ4 alcohol dehydrogenase ELZ77_19850 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ELZ77_19855 ENOG4105CPQ Dehydrogenase ELZ77_19860 ENOG4105CHR reductase ELZ77_19865 ENOG4105C6Z Gluconate ELZ77_19870 ENOG4105K2J Transcriptional regulator ELZ77_19875 ENOG4108K5H permease YjgP YjgQ family protein ELZ77_19880 ENOG4108M8S permease YjgP YjgQ family protein ELZ77_19895 ENOG4105MYG DNA polymerase iii, chi subunit ELZ77_19900 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ELZ77_19905 ENOG4108M3P Membrane ELZ77_19910 ENOG4108MJ3 acetyltransferase ELZ77_19920 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase ELZ77_19925 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) ELZ77_19930 ENOG4105DBV ornithine carbamoyltransferase ELZ77_19935 ENOG4105XEP YhcH YjgK YiaL family protein ELZ77_19950 ENOG4105CEU Arginine dihydrolase ELZ77_19955 ENOG4105C5B carbamate kinase ELZ77_19960 ENOG4105DBV ornithine carbamoyltransferase ELZ77_19965 ENOG4105CSX c4-dicarboxylate anaerobic carrier ELZ77_19970 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) ELZ77_19980 ENOG41077AM PyrBI operon attenuator ELZ77_19995 ENOG4105KME endoribonuclease L-psp ELZ77_20015 ENOG4105D4X repressor ELZ77_20020 ENOG4105C5Y PTS System ELZ77_20025 ENOG4105CG3 alpha amylase, catalytic region ELZ77_20035 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ELZ77_20040 ENOG4105K4U addiction module toxin, RelE StbE family ELZ77_20050 ENOG4105EMD TRANSCRIPTIONal ELZ77_20065 ENOG41069H0 dihydroorotase EC 3.5.2.3 ELZ77_20095 ENOG4108XVM Cytochrome b(562) ELZ77_20100 ENOG4105CMS peptidase U62, modulator of DNA gyrase ELZ77_20110 ENOG4105DFU Cell wall formation (By similarity) ELZ77_20120 ENOG4105F0N pyrophosphate phospho-hydrolase ELZ77_20125 ENOG41069H0 dihydroorotase EC 3.5.2.3 ELZ77_20130 ENOG4105DJB Major Facilitator Superfamily ELZ77_20135 ENOG4108ZHD aig2 family ELZ77_20155 ENOG4105C37 (CBS) domain ELZ77_20160 ENOG41061GZ Protein of unknown function (DUF1107) ELZ77_20170 ENOG4108UUE Transcriptional regulator ELZ77_20175 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ELZ77_20185 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ELZ77_20190 ENOG4105KVH Transcriptional regulator ELZ77_20195 ENOG4105ECR NmrA family ELZ77_20225 ENOG4108V1T peptidylprolyl cis-trans isomerase ELZ77_20230 ENOG4105FHY Opacity-associated protein A ELZ77_20245 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ELZ77_20255 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ELZ77_20270 ENOG4105KIT UPF0379 protein yjfY ELZ77_20275 ENOG4105R3P Inner membrane protein yagU ELZ77_20300 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport ELZ77_20305 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC ELZ77_20320 ENOG4108MXZ Esterase ELZ77_20325 ENOG4105WSB biofilm stress and motility protein A ELZ77_20330 ENOG4105S17 UPF0379 protein yjfN ELZ77_20335 ENOG4105CSU acyl-Coa dehydrogenase ELZ77_20340 ENOG4106032 Glutathionylspermidine synthase ELZ77_20345 ENOG4108KXT Conserved Protein ELZ77_20350 ENOG4105Z6B inner membrane protein yjfl ELZ77_20355 ENOG4107VNS Protein of unknown function (DUF2491) ELZ77_20360 ENOG4108P9J Phage shock protein A ELZ77_20365 ENOG4105FUX Conserved Protein ELZ77_20370 ENOG4105C2N RNA methyltransferase TrmH family group 3 ELZ77_20375 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ELZ77_20395 ENOG4105EPW hflc protein ELZ77_20400 ENOG4107QJR hflk protein ELZ77_20405 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ELZ77_20420 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ELZ77_20425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ELZ77_20430 ENOG4105K8N protein family UPF0079, ATPase ELZ77_20435 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ELZ77_20440 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ELZ77_20455 ENOG4106TNF Periplasmic binding protein ELZ77_20480 ENOG4106V5W ELZ77_20485 ENOG4107SC7 Inner membrane transporter yjeM ELZ77_20495 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ELZ77_20500 ENOG4105E33 succinate dehydrogenase ELZ77_20520 ENOG4105KPY Small multidrug resistance protein ELZ77_20530 ENOG4106BSU Entericidin B ELZ77_20550 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ELZ77_20555 ENOG4105MTB Uncharacterized protein YjeJ ELZ77_20560 ENOG4108ZVF (LipO)protein ELZ77_20575 ENOG4105DVH amino acid ELZ77_20580 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ELZ77_20585 ENOG4108IJ0 Aspartate ammonia-lyase ELZ77_20590 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ELZ77_20605 ENOG4108SIC Transcriptional regulator ELZ77_20620 ENOG4105SBG acid phosphatase ELZ77_20655 ENOG41068CG regulatoR ELZ77_20665 ENOG4108ZK4 sdia-regulated domain-containing protein ELZ77_20680 ENOG4108NEM leader-binding protein dmsD ELZ77_20685 ENOG4107KGK dmso reductase anchor subunit ELZ77_20690 ENOG4105QAX Iron-sulfur ELZ77_20695 ENOG4107QY8 reductase ELZ77_20700 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ELZ77_20705 ENOG4108MRH transcriptional regulatory protein ELZ77_20715 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ELZ77_20720 ENOG4107GFK fumarate ELZ77_20725 ENOG4105CT4 transporter ELZ77_20730 ENOG4105F8D glycoside hydrolase family 4 ELZ77_20735 ENOG4108K2B transcriptional regulator ELZ77_20740 ENOG4105CXN decarboxylase ELZ77_20745 ENOG4106ZGR Transcriptional regulator ELZ77_20750 ENOG4105D5Q Arginine ornithine antiporter ELZ77_20755 ENOG4105DIJ Phosphoethanolamine transferase ELZ77_20760 ENOG4105XJC Two component transcriptional regulator (Winged helix family ELZ77_20765 ENOG4105ECM Sensor protein basS pmrB ELZ77_20775 ENOG4105CSH Transporter ELZ77_20780 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ELZ77_20785 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase ELZ77_20790 ENOG4108YZG isomerase ELZ77_20795 ENOG4105NYY transcriptional regulator, RpiR ELZ77_20800 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ELZ77_20805 ENOG4105C2J ABC transporter ELZ77_20810 ENOG4105CNN ABC, transporter ELZ77_20815 ENOG4105UP7 3-epimerase ELZ77_20820 ENOG4107TFG D-allose kinase ELZ77_20835 ENOG41082ND Uncharacterized protein yjcO ELZ77_20840 ENOG4105CK2 sodium dicarboxylate symporter ELZ77_20845 ENOG4108W0S formate-dependent nitrite reductase complex ELZ77_20855 ENOG4105DVI reductase, NrfD ELZ77_20860 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ELZ77_20865 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit ELZ77_20880 ENOG41062QD Membrane ELZ77_20890 ENOG41067MG lrgb family ELZ77_20900 ENOG4105CMU LysR family (Transcriptional regulator ELZ77_20905 ENOG4105EEQ Na H antiporter ELZ77_20915 ENOG4105C7N Xanthine uracil vitamin C permease ELZ77_20925 ENOG4108Z4X TRANSCRIPTIONal ELZ77_20930 ENOG4108W3Q Transcriptional regulator ELZ77_20935 ENOG4108M8H domain protein ELZ77_20940 ENOG4105PMV Membrane ELZ77_20975 ENOG4108UUM single-stranded DNA-binding protein ELZ77_20985 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ELZ77_21000 ENOG4105MSB protein, conserved in bacteria ELZ77_21005 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ELZ77_21010 ENOG4105F0S class B acid phosphatase ELZ77_21015 ENOG4105CGF Aromatic amino acid aminotransferase ELZ77_21020 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ELZ77_21025 ENOG4105CDU Replicative dna helicase ELZ77_21035 ENOG4105P4Z Phage shock protein G ELZ77_21040 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ELZ77_21050 ENOG4105MYN Zinc uptake regulation protein ELZ77_21055 ENOG4105VDW Csbd family ELZ77_21065 ENOG4107R73 Mate efflux family protein ELZ77_21075 ENOG41080IJ Diacylglycerol kinase ELZ77_21095 ENOG4107W52 maltose operon periplasmic protein ELZ77_21110 ENOG4107FKK extracellular solute-binding protein family 1 ELZ77_21120 ENOG4105D56 permease protein ELZ77_21125 ENOG4105EG2 ABC transporter, permease ELZ77_21135 ENOG4105E3R (LipO)protein ELZ77_21140 ENOG4108Q9C Periplasmic Protein ELZ77_21145 ENOG4108MDC (LipO)protein ELZ77_21160 ENOG4105CFH Aspartokinase ELZ77_21180 ENOG410667J hydrolase ELZ77_21185 ENOG4105E98 transcriptional regulator DeoR family ELZ77_21190 ENOG4108ZR5 Conserved Protein ELZ77_21195 ENOG4105FE9 pseudouridine synthase ELZ77_21200 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme ELZ77_21215 ENOG4105EAM Na Pi-cotransporter ELZ77_21225 ENOG41069M3 Transcriptional regulator ELZ77_21240 ENOG4108I9X Isocitrate lyase ELZ77_21245 ENOG4107QP3 malate synthase g ELZ77_21255 ENOG4105K5X acetyltransferase ELZ77_21280 ENOG4105DC1 bifunctional purine biosynthesis protein purh ELZ77_21285 ENOG4105C12 Phosphoribosylglycinamide synthetase ELZ77_21290 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ELZ77_21295 ENOG4105BZU Histidine kinase ELZ77_21305 ENOG4108T8B Protein of unknown function (DUF1481) ELZ77_21310 ENOG4105K70 DNA-binding protein ELZ77_21315 ENOG4105R2J Conserved Protein ELZ77_21350 ENOG4105D06 uba thif-type nad fad binding protein ELZ77_21355 ENOG4105WHD thiamine biosynthesis protein ThiS ELZ77_21365 ENOG4105D41 biosynthesis protein thiH ELZ77_21395 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ELZ77_21415 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ELZ77_21420 ENOG4105PM1 preprotein translocase subunit SecE ELZ77_21425 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ELZ77_21460 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ELZ77_21465 ENOG4105D4A Cell wall formation (By similarity) ELZ77_21505 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ELZ77_21515 ENOG4108Y73 Membrane ELZ77_21530 ENOG4105C5Q Transcriptional regulator ELZ77_21540 ENOG4105CH7 arginosuccinase ELZ77_21570 ENOG4105DIJ Phosphoethanolamine transferase ELZ77_21575 ENOG4106R3P AraC family transcriptional regulator ELZ77_21585 ENOG4105DCT glycerol dehydrogenase ELZ77_21595 ENOG4105SYT Methylenetetrahydrofolate reductase ELZ77_21600 ENOG4105CGH 5'-nucleotidase ELZ77_21620 ENOG4105C28 cystathionine ELZ77_21645 ENOG4105C25 Primosomal protein n' ELZ77_21650 ENOG4105ETE Transcriptional regulator (LacI family ELZ77_21655 ENOG41063M6 Cell Division Protein ELZ77_21670 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ELZ77_21680 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) ELZ77_21685 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ELZ77_21700 ENOG4105DP0 ferredoxin-NADP reductase ELZ77_21705 ENOG4108VTS Membrane ELZ77_21710 ENOG4105EBK exported protein ELZ77_21735 ENOG4105D7K pfkb domain protein ELZ77_21740 ENOG4105CT4 transporter ELZ77_21750 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ELZ77_21765 ENOG4105FMW periplasmic ELZ77_21770 ENOG4105E3W Two component transcriptional regulator (Winged helix family ELZ77_21785 ENOG4108RPX mosc domain containing protein ELZ77_21790 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ELZ77_21795 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ELZ77_21800 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter ELZ77_21805 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ELZ77_21810 ENOG4108QGT oligogalacturonate-specific porin ELZ77_21845 ENOG4105C0A alcohol dehydrogenase ELZ77_21860 ENOG4108UMN azlc family ELZ77_21870 ENOG4108V87 frv operon regulatory protein ELZ77_21875 ENOG4108V87 frv operon regulatory protein ELZ77_21885 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ELZ77_21890 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ELZ77_21895 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ELZ77_21900 ENOG4108MG3 formate dehydrogenase ELZ77_21915 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system ELZ77_21925 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) ELZ77_21930 ENOG4108Z3N Transcriptional regulator ELZ77_21935 ENOG4105SUU thioesterase domain ELZ77_21950 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 ELZ77_21955 ENOG4105E98 transcriptional regulator DeoR family ELZ77_21960 ENOG4108MGF sugar kinase ELZ77_21965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ELZ77_21970 ENOG4105D2M Aldolase ELZ77_21990 ENOG4105CT4 transporter ELZ77_21995 ENOG4105CT4 transporter ELZ77_22000 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is ELZ77_22030 ENOG4108K4B hydrolase ELZ77_22040 ENOG4105C5F glutamine synthetase ELZ77_22050 ENOG4105CUX Signal transduction histidine kinase ELZ77_22055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ELZ77_22060 ENOG4106FIY ELZ77_22065 ENOG4105D4P Coproporphyrinogen iii oxidase ELZ77_22085 ENOG4105C2M dna polymerase I ELZ77_22095 ENOG4106HNH Acyl-transferase ELZ77_22110 ENOG4105PC1 Conserved Protein ELZ77_22115 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ELZ77_22120 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b ELZ77_22150 ENOG4108RR8 protoporphyrinogen oxidase ELZ77_22155 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ELZ77_22160 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ELZ77_22180 ENOG4108MR7 Arylsulfotransferase ELZ77_22185 ENOG4107QK7 reductase ELZ77_22190 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ELZ77_22195 ENOG4105MDZ Transcriptional activator rfaH ELZ77_22200 ENOG4105F8V Hydrolase, tatD family ELZ77_22205 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ELZ77_22210 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ELZ77_22215 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ELZ77_22225 ENOG4105JC1 sterol-binding domain protein ELZ77_22235 ENOG4105CGY Dna recombination protein ELZ77_22240 ENOG4108I5U Uridine phosphorylase ELZ77_22245 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) ELZ77_22250 ENOG4105C4X radical SAM domain protein ELZ77_22265 ENOG4105DZ2 Transcriptional regulator ELZ77_22270 ENOG4105EMK carboxylate amino acid amine transporter ELZ77_22275 ENOG4105DQF Hydrolase ELZ77_22280 ENOG4108EUD Lysophospholipase ELZ77_22285 ENOG410829K Lysine exporter protein (Lyse ygga) ELZ77_22290 ENOG4105CCF Lysine exporter protein (Lyse ygga) ELZ77_22295 ENOG4105C9U ATP-dependent DNA helicase RecQ ELZ77_22300 ENOG4105HDD phospholipase ELZ77_22305 ENOG4108VUY thioesterase Superfamily protein ELZ77_22310 ENOG4105FR1 rard protein ELZ77_22335 ENOG4105C4R Atp-dependent dna helicase ELZ77_22340 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ELZ77_22345 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ELZ77_22350 ENOG4105CT0 Protein of unknown function, DUF484 ELZ77_22360 ENOG4105S7Z (LipO)protein ELZ77_22405 ENOG41076E6 Uroporphyrinogen-III Synthase ELZ77_22410 ENOG4105ECF c-methyltransferase ELZ77_22415 ENOG410601J HemY protein ELZ77_22440 ENOG4105C85 amino acid ELZ77_22455 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) ELZ77_22460 ENOG4105EGZ biosynthesis protein ELZ77_22465 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ELZ77_22470 ENOG4108WJ1 acetyltransferase ELZ77_22475 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ELZ77_22475 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ELZ77_22480 ENOG4105C1B dTDP-glucose 4-6-dehydratase ELZ77_22485 ENOG4108IJ1 Dehydrogenase ELZ77_22490 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ELZ77_22495 ENOG4105SFE lipopolysaccharide biosynthesis protein ELZ77_22500 ENOG4105ESV Glycosyl transferase, family 4 ELZ77_22515 ENOG4105K63 Thioredoxin ELZ77_22530 ENOG4105C4R Atp-dependent dna helicase ELZ77_22535 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ELZ77_22545 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ELZ77_22550 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ELZ77_22555 ENOG4105EMY transcriptional regulator ELZ77_22570 ENOG4105C7B Threonine dehydratase ELZ77_22580 ENOG4105CM2 brancheD-chain amino acid aminotransferase ELZ77_22585 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit ELZ77_22605 ENOG4105C0P Mg chelatase subunit ChlI ELZ77_22650 ENOG4107EJG GntR family transcriptional regulator ELZ77_22655 ENOG4105C0R drug resistance transporter emrb qaca subfamily ELZ77_22660 ENOG4105ETE Transcriptional regulator (LacI family ELZ77_22665 ENOG4108RVA ribokinase ELZ77_22670 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ELZ77_22675 ENOG4105CNN ABC, transporter ELZ77_22710 ENOG4108VVK transcriptional Regulator, AsnC ELZ77_22715 ENOG4105QTB Flavodoxin ELZ77_22735 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation ELZ77_22745 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ELZ77_22775 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ELZ77_22800 ENOG4108RQP Major type 1 subunit fimbrin ELZ77_22805 ENOG4108NAE Fimbrial chaperone protein ELZ77_22810 ENOG4105CW0 outer membrane usher protein ELZ77_22815 ENOG4105I74 Fimbrial protein ELZ77_22820 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ELZ77_22825 ENOG4105F9E Shikimate 5-dehydrogenase ELZ77_22830 ENOG4105DM4 PTS System ELZ77_22835 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ELZ77_22840 ENOG4105C8U phosphate abc transporter ELZ77_22845 ENOG4105E2Z phosphate ABC transporter (Permease ELZ77_22860 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 ELZ77_22865 ENOG4105C7N Xanthine uracil vitamin C permease ELZ77_22870 ENOG4108YYH Nadph-dependent fmn reductase ELZ77_22875 ENOG4105E8Q phosphopantetheinyl transferase