locus-tag	class	description
HU143_00030	COG4948	Mandelate Racemase Muconate Lactonizing
HU143_00035	COG2271	Major facilitator Superfamily
HU143_00040	COG0561	phosphatase activity
HU143_00045	COG2186	Transcriptional regulator
HU143_00050	COG3734	2-keto-3-deoxy-galactonokinase
HU143_00055	COG0800	Aldolase
HU143_00065	COG2271	Major facilitator Superfamily
HU143_00070	COG2198	Histidine kinase
HU143_00070	COG0784	Response regulator, receiver
HU143_00070	COG2205	protein histidine kinase activity
HU143_00075	COG1879	ABC-type sugar transport system periplasmic component
HU143_00080	COG0745	RESPONSE REGULATOR receiver
HU143_00085	COG3005	denitrification pathway
HU143_00100	COG1858	cytochrome C peroxidase
HU143_00110	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HU143_00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HU143_00120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HU143_00140	COG3088	subunit of a heme lyase
HU143_00140	COG4235	cytochrome complex assembly
HU143_00145	COG0823	Involved in the tonB-independent uptake of proteins
HU143_00150	COG5645	(Lipo)protein
HU143_00170	COG2149	membrane
HU143_00180	COG0641	radical SAM
HU143_00190	COG2610	gluconate transmembrane transporter activity
HU143_00195	COG0583	DNA-binding transcription factor activity
HU143_00205	COG2814	Major facilitator Superfamily
HU143_00230	COG0028	Belongs to the TPP enzyme family
HU143_00235	COG0440	acetolactate synthase activity
HU143_00240	COG1349	DNA-binding transcription factor activity
HU143_00250	COG0738	Major facilitator superfamily
HU143_00285	COG2188	Transcriptional regulator
HU143_00290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_00290	COG3711	transcriptional antiterminator
HU143_00295	COG3414	Phosphotransferase system galactitol-specific IIB component
HU143_00300	COG3775	system Galactitol-specific IIC component
HU143_00335	COG2723	6-phospho-beta-galactosidase activity
HU143_00355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_00355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HU143_00360	COG3715	PTS system
HU143_00365	COG3716	PTS system mannose fructose sorbose family IID component
HU143_00380	COG5464	transposase or invertase
HU143_00410	COG1335	isochorismatase
HU143_00420	COG3710	Transcriptional regulator
HU143_00435	COG2771	luxR family
HU143_00455	COG0419	ATPase involved in DNA repair
HU143_00475	COG2211	Major facilitator Superfamily
HU143_00480	COG1501	Belongs to the glycosyl hydrolase 31 family
HU143_00485	COG2982	Protein involved in outer membrane biogenesis
HU143_00490	COG2233	PERMEase
HU143_00495	COG0786	glutamate:sodium symporter activity
HU143_00500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HU143_00505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HU143_00510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HU143_00530	COG2860	membrane
HU143_00540	COG0583	DNA-binding transcription factor activity
HU143_00545	COG1561	YicC-like family, N-terminal region
HU143_00570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HU143_00600	COG1519	Transferase
HU143_00605	COG0859	PFAM glycosyl transferase family 9
HU143_00610	COG0438	transferase activity, transferring glycosyl groups
HU143_00685	COG1216	Glycosyl transferase, family 2
HU143_00690	COG2861	carbohydrate metabolic process
HU143_00695	COG4942	peptidase
HU143_00705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HU143_00710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HU143_00730	COG2271	Major facilitator Superfamily
HU143_00740	COG1609	Transcriptional regulator
HU143_00745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HU143_00755	COG2186	Transcriptional regulator
HU143_00785	COG3722	fumarate hydratase activity
HU143_00790	COG0246	Mannitol dehydrogenase
HU143_00795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_00795	COG2213	PTS system mannitol-specific
HU143_00800	COG0625	glutathione transferase activity
HU143_00810	COG3276	selenocysteine insertion sequence binding
HU143_00815	COG1940	carbohydrate kinase activity
HU143_00820	COG1012	belongs to the aldehyde dehydrogenase family
HU143_00835	COG0235	Class ii aldolase
HU143_00840	COG3623	hexulose-6-phosphate isomerase
HU143_00845	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HU143_00850	COG1070	Carbohydrate kinase
HU143_00855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HU143_00860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HU143_00865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HU143_00875	COG2731	YhcH YjgK YiaL family protein
HU143_00885	COG1414	Transcriptional regulator
HU143_00890	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_00895	COG3977	Valine--pyruvate aminotransferase
HU143_00900	COG0366	Alpha amylase catalytic
HU143_00905	COG2992	FlgJ-related protein
HU143_00910	COG2207	Transcriptional regulator
HU143_00910	COG1609	Transcriptional regulator
HU143_00915	COG2115	Belongs to the xylose isomerase family
HU143_00920	COG1070	Carbohydrate kinase
HU143_00925	COG4682	membrane
HU143_00930	COG3274	enterobacterial common antigen metabolic process
HU143_00960	COG1278	Cold shock
HU143_00965	COG2944	sequence-specific DNA binding
HU143_00980	COG2885	chlorophyll binding
HU143_00985	COG0243	molybdopterin cofactor binding
HU143_00990	COG0456	acetyltransferase
HU143_00995	COG2818	Glycosylase
HU143_01000	COG5571	outer membrane autotransporter
HU143_01030	COG1609	Transcriptional regulator
HU143_01045	COG0747	negative chemotaxis
HU143_01050	COG0601	transmembrane transport
HU143_01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HU143_01060	COG0444	Belongs to the ABC transporter superfamily
HU143_01065	COG4608	Belongs to the ABC transporter superfamily
HU143_01070	COG0814	amino acid
HU143_01115	COG1215	transferase activity, transferring glycosyl groups
HU143_01130	COG2199	diguanylate cyclase activity
HU143_01130	COG2200	EAL domain
HU143_01145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_01150	COG2200	EAL domain
HU143_01155	COG2982	Protein involved in outer membrane biogenesis
HU143_01160	COG0477	Major facilitator Superfamily
HU143_01165	COG1295	ribonuclease BN
HU143_01170	COG0583	DNA-binding transcription factor activity
HU143_01175	COG2197	response regulator
HU143_01195	COG2188	Transcriptional regulator
HU143_01200	COG2222	sugar isomerase
HU143_01205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_01210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HU143_01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HU143_01225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HU143_01230	COG0671	phosphoesterase, PA-phosphatase related
HU143_01260	COG0306	phosphate transporter
HU143_01265	COG2081	HI0933 family
HU143_01270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_01275	COG0842	Transport permease protein
HU143_01275	COG1129	ABC transporter
HU143_01280	COG0842	Transport permease protein
HU143_01295	COG0628	permease
HU143_01310	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HU143_01330	COG3714	YhhN family
HU143_01340	COG3776	membrane
HU143_01345	COG0742	ribosomal rna small subunit methyltransferase
HU143_01350	COG0552	protein localization to endoplasmic reticulum
HU143_01355	COG2884	Cell division ATP-binding protein ftsE
HU143_01360	COG2177	Part of the ABC transporter FtsEX involved in
HU143_01435	COG0584	glycerophosphoryl diester phosphodiesterase
HU143_01445	COG0405	Gamma-glutamyltransferase
HU143_01450	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HU143_01465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_01470	COG1247	-acetyltransferase
HU143_01475	COG0673	inositol 2-dehydrogenase activity
HU143_01480	COG1741	Belongs to the pirin family
HU143_01485	COG1609	Transcriptional regulator
HU143_01490	COG3265	gluconokinase activity
HU143_01495	COG2610	gluconate transmembrane transporter activity
HU143_01510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HU143_01530	COG0058	SHG alpha-glucan phosphorylase activity
HU143_01535	COG1414	Transcriptional regulator
HU143_01540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HU143_01545	COG0129	dihydroxy-acid dehydratase activity
HU143_01555	COG0371	Dehydrogenase
HU143_01570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HU143_01585	COG1349	DNA-binding transcription factor activity
HU143_01595	COG0058	SHG alpha-glucan phosphorylase activity
HU143_01600	COG1640	4-alpha-glucanotransferase
HU143_01605	COG2610	gluconate transmembrane transporter activity
HU143_01615	COG1040	competence protein
HU143_01625	COG5464	transposase or invertase
HU143_01640	COG1918	ferrous iron import across plasma membrane
HU143_01645	COG2183	response to ionizing radiation
HU143_01650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HU143_01670	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HU143_01680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HU143_01685	COG1011	Hydrolase
HU143_01695	COG0494	nUDIX hydrolase
HU143_01700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HU143_01705	COG4972	Pilus assembly protein
HU143_01710	COG3166	PFAM Fimbrial assembly family protein
HU143_01725	COG4796	Type ii and iii secretion system protein
HU143_01740	COG3266	domain, Protein
HU143_01745	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HU143_01750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HU143_01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HU143_01800	COG0738	Major facilitator superfamily
HU143_01830	COG1289	transmembrane transporter activity
HU143_01840	COG1765	OsmC-like protein
HU143_01845	COG3954	Phosphoribulokinase
HU143_01855	COG0429	hydrolase of the alpha beta-hydrolase fold
HU143_01870	COG0488	(ABC) transporter
HU143_01885	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HU143_01890	COG1047	Peptidyl-prolyl cis-trans
HU143_01900	COG0545	Peptidyl-prolyl cis-trans isomerase
HU143_01905	COG2964	Protein conserved in bacteria
HU143_01960	COG0051	transcription antitermination factor activity, RNA binding
HU143_01985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HU143_02065	COG0201	protein transport
HU143_02105	COG0789	Transcriptional regulator
HU143_02110	COG3036	rescue of stalled ribosome
HU143_02140	COG0758	DNA mediated transformation
HU143_02150	COG0551	DNA topoisomerase type I activity
HU143_02170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HU143_02215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HU143_02220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_02225	COG1309	transcriptional regulator
HU143_02240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HU143_02265	COG4145	pantothenate transmembrane transporter activity
HU143_02270	COG3924	membrane
HU143_02275	COG0439	Biotin carboxylase
HU143_02280	COG0511	ligase activity, forming carbon-carbon bonds
HU143_02295	COG0604	alcohol dehydrogenase
HU143_02300	COG2200	EAL domain
HU143_02300	COG2199	diguanylate cyclase activity
HU143_02305	COG1077	Cell shape determining protein MreB Mrl
HU143_02310	COG1792	Involved in formation and maintenance of cell shape
HU143_02315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HU143_02330	COG3164	Protein of unknown function
HU143_02335	COG0312	modulator of DNA gyrase
HU143_02340	COG0583	DNA-binding transcription factor activity
HU143_02365	COG2732	(Barnase) inhibitor
HU143_02390	COG2188	Transcriptional regulator
HU143_02400	COG0471	metal ion transport
HU143_02405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HU143_02410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HU143_02415	COG3630	sodium ion export across plasma membrane
HU143_02420	COG0511	ligase activity, forming carbon-carbon bonds
HU143_02420	COG5016	pyruvate
HU143_02425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HU143_02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HU143_02445	COG3105	Protein conserved in bacteria
HU143_02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HU143_02470	COG0625	glutathione transferase activity
HU143_02475	COG2969	positive regulation of protein catabolic process
HU143_02505	COG2731	YhcH YjgK YiaL family protein
HU143_02510	COG0402	S-adenosylhomocysteine deaminase activity
HU143_02515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HU143_02520	COG4804	nuclease activity
HU143_02525	COG0493	'glutamate synthase
HU143_02530	COG0069	glutamate synthase activity
HU143_02530	COG0070	glutamate synthase
HU143_02530	COG0067	glutamate synthase
HU143_02535	COG1242	4 iron, 4 sulfur cluster binding
HU143_02540	COG2198	Histidine kinase
HU143_02540	COG0784	Response regulator, receiver
HU143_02540	COG5002	protein histidine kinase activity
HU143_02545	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HU143_02555	COG0515	serine threonine protein kinase
HU143_02560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_02585	COG1137	ATPase activity
HU143_02590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HU143_02595	COG3117	lipopolysaccharide transmembrane transporter activity
HU143_02600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HU143_02610	COG0530	calcium, potassium:sodium antiporter activity
HU143_02615	COG1127	ABC transporter
HU143_02620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HU143_02625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HU143_02630	COG2854	intermembrane phospholipid transfer
HU143_02635	COG3113	response to antibiotic
HU143_02640	COG5007	Belongs to the BolA IbaG family
HU143_02650	COG3423	Transcriptional regulator
HU143_02655	COG0142	geranyltranstransferase activity
HU143_02670	COG0697	spore germination
HU143_02680	COG2027	D-alanyl-D-alanine carboxypeptidase
HU143_02690	COG1534	Rna-binding protein
HU143_02705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HU143_02715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HU143_02785	COG0513	Belongs to the DEAD box helicase family
HU143_02790	COG0814	amino acid
HU143_02800	COG3034	peptidoglycan biosynthetic process
HU143_02805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HU143_02810	COG0826	peptidase U32
HU143_02815	COG0826	peptidase U32
HU143_02820	COG3154	lipid carrier protein
HU143_02825	COG3153	acetyltransferase
HU143_02840	COG0693	protein deglycase activity
HU143_02845	COG0702	epimerase
HU143_02850	COG2823	Periplasmic or secreted lipoprotein
HU143_02865	COG3107	peptidoglycan biosynthetic process
HU143_02870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HU143_02880	COG1063	alcohol dehydrogenase
HU143_02885	COG3775	system Galactitol-specific IIC component
HU143_02890	COG3414	Phosphotransferase system galactitol-specific IIB component
HU143_02895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_02910	COG2721	sulfolactate sulfo-lyase activity
HU143_02920	COG2084	Dehydrogenase
HU143_02925	COG1929	Belongs to the glycerate kinase type-1 family
HU143_02935	COG0583	DNA-binding transcription factor activity
HU143_02950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HU143_02960	COG1882	Formate acetyltransferase
HU143_02965	COG1760	l-serine dehydratase
HU143_02970	COG0814	amino acid
HU143_02985	COG1741	Belongs to the pirin family
HU143_02990	COG0583	DNA-binding transcription factor activity
HU143_02995	COG3152	Membrane
HU143_03000	COG0435	Glutathione S-transferase
HU143_03005	COG2259	Doxx family
HU143_03015	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HU143_03020	COG4575	ribosome binding
HU143_03025	COG1422	Protein of unknown function (DUF1090)
HU143_03035	COG0586	Pfam SNARE associated Golgi protein
HU143_03050	COG0673	inositol 2-dehydrogenase activity
HU143_03055	COG2949	membrane
HU143_03060	COG1451	nucleotide metabolic process
HU143_03070	COG1902	pentaerythritol trinitrate reductase activity
HU143_03070	COG0446	pyridine nucleotide-disulphide oxidoreductase
HU143_03080	COG0840	transmembrane signaling receptor activity
HU143_03090	COG0840	transmembrane signaling receptor activity
HU143_03095	COG1695	Transcriptional regulator
HU143_03100	COG2375	cellular response to nickel ion
HU143_03105	COG4974	Belongs to the 'phage' integrase family
HU143_03150	COG2176	DNA-directed DNA polymerase activity
HU143_03150	COG5002	protein histidine kinase activity
HU143_03180	COG4695	Portal protein
HU143_03275	COG5301	cellulose 1,4-beta-cellobiosidase activity
HU143_03305	COG0582	viral genome integration into host DNA
HU143_03340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HU143_03375	COG4695	Portal protein
HU143_03460	COG5301	cellulose 1,4-beta-cellobiosidase activity
HU143_03535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HU143_03560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HU143_03575	COG4991	sh3 domain protein
HU143_03580	COG3025	triphosphatase activity
HU143_03600	COG2268	Band 7 protein
HU143_03605	COG1585	Membrane protein implicated in regulation of membrane protease activity
HU143_03645	COG3384	dioxygenase
HU143_03650	COG0754	glutathionylspermidine amidase activity
HU143_03665	COG0494	nUDIX hydrolase
HU143_03670	COG3151	Protein conserved in bacteria
HU143_03675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HU143_03680	COG3150	esterase
HU143_03690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HU143_03695	COG2249	NAD(P)H dehydrogenase (quinone) activity
HU143_03710	COG3111	PFAM Bacterial OB fold (BOF) protein
HU143_03715	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HU143_03765	COG0471	metal ion transport
HU143_03775	COG1979	alcohol dehydrogenase
HU143_03780	COG2207	Transcriptional regulator
HU143_03800	COG0848	biopolymer transport protein
HU143_03805	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_03830	COG0840	transmembrane signaling receptor activity
HU143_03840	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HU143_03845	COG0437	4 iron, 4 sulfur cluster binding
HU143_03850	COG5557	Pfam Polysulphide reductase, NrfD
HU143_03855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HU143_03860	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HU143_03865	COG1773	rubredoxin
HU143_03875	COG0298	carbon dioxide binding
HU143_03880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HU143_03890	COG0625	glutathione transferase activity
HU143_03895	COG0754	glutathionylspermidine amidase activity
HU143_03910	COG0246	Mannitol dehydrogenase
HU143_03920	COG2271	Major facilitator Superfamily
HU143_03955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HU143_03980	COG1811	Na channel or pump
HU143_03985	COG1982	Orn Lys Arg decarboxylase major
HU143_03990	COG2211	Major facilitator Superfamily
HU143_04015	COG3171	Protein conserved in bacteria
HU143_04025	COG0252	asparaginase activity
HU143_04035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HU143_04040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HU143_04050	COG0762	integral membrane protein
HU143_04055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HU143_04060	COG2805	Type II/IV secretion system protein
HU143_04085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HU143_04090	COG2356	endonuclease I
HU143_04100	COG2814	Major facilitator Superfamily
HU143_04125	COG1166	arginine decarboxylase activity
HU143_04135	COG0501	Belongs to the peptidase M48B family
HU143_04140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HU143_04145	COG1122	ATPase activity
HU143_04150	COG1122	ATPase activity
HU143_04180	COG0191	fructose-bisphosphate aldolase activity
HU143_04185	COG0668	transmembrane transport
HU143_04195	COG2968	Membrane
HU143_04215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HU143_04220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HU143_04240	COG0006	proline dipeptidase activity
HU143_04245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HU143_04250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HU143_04275	COG2723	6-phospho-beta-galactosidase activity
HU143_04285	COG1272	protein, Hemolysin III
HU143_04345	COG4942	peptidase
HU143_04390	COG3188	usher protein
HU143_04425	COG0814	amino acid
HU143_04440	COG0183	Belongs to the thiolase family
HU143_04450	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_04455	COG2814	Major facilitator Superfamily
HU143_04460	COG1794	racemase activity, acting on amino acids and derivatives
HU143_04465	COG0583	DNA-binding transcription factor activity
HU143_04475	COG1609	Transcriptional regulator
HU143_04495	COG0667	Aldo Keto reductase
HU143_04505	COG0861	Integral membrane protein TerC family
HU143_04535	COG2165	general secretion pathway protein
HU143_04540	COG4795	General secretion pathway protein
HU143_04550	COG4967	type IV pilus modification protein PilV
HU143_04555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HU143_04560	COG1025	Belongs to the peptidase M16 family
HU143_04565	COG1074	ATP-dependent DNA helicase activity
HU143_04570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HU143_04575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HU143_04575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HU143_04580	COG0860	N-Acetylmuramoyl-L-alanine amidase
HU143_04595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HU143_04600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HU143_04605	COG2962	Rard protein
HU143_04610	COG2166	iron-sulfur cluster assembly
HU143_04615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HU143_04625	COG0583	DNA-binding transcription factor activity
HU143_04630	COG2363	Small membrane protein
HU143_04640	COG1349	DNA-binding transcription factor activity
HU143_04660	COG0738	Major facilitator superfamily
HU143_04665	COG0235	Class ii aldolase
HU143_04670	COG1454	alcohol dehydrogenase
HU143_04680	COG1760	l-serine dehydratase
HU143_04685	COG0814	amino acid
HU143_04690	COG1611	Belongs to the LOG family
HU143_04715	COG0716	FMN binding
HU143_04725	COG2271	Major facilitator Superfamily
HU143_04730	COG4948	Mandelate Racemase Muconate Lactonizing
HU143_04735	COG4948	Mandelate Racemase Muconate Lactonizing
HU143_04740	COG1929	Belongs to the glycerate kinase type-1 family
HU143_04745	COG4999	Histidine kinase
HU143_04745	COG3850	Histidine kinase
HU143_04745	COG3437	response regulator, receiver
HU143_04745	COG2205	protein histidine kinase activity
HU143_04755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HU143_04760	COG3609	addiction module antidote protein, CC2985 family
HU143_04790	COG3539	Fimbrial protein
HU143_04795	COG3121	Chaperone
HU143_04800	COG3188	usher protein
HU143_04805	COG3539	Fimbrial protein
HU143_04810	COG3956	TIGRFAM MazG family protein
HU143_04825	COG0602	queuosine metabolic process
HU143_04830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HU143_04830	COG0321	lipoyl(octanoyl) transferase activity
HU143_04835	COG0720	synthase
HU143_04860	COG1203	CRISPR-associated helicase, Cas3
HU143_04875	COG1857	crispr-associated protein
HU143_04890	COG1518	maintenance of DNA repeat elements
HU143_04895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HU143_04900	COG2234	aminopeptidase activity
HU143_04970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HU143_04975	COG0163	prenyltransferase activity
HU143_04985	COG1349	DNA-binding transcription factor activity
HU143_04990	COG2084	Dehydrogenase
HU143_05000	COG0235	Class ii aldolase
HU143_05005	COG3622	Belongs to the hyi family
HU143_05010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU143_05015	COG2610	gluconate transmembrane transporter activity
HU143_05025	COG0477	Major facilitator Superfamily
HU143_05105	COG2207	Transcriptional regulator
HU143_05195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HU143_05275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HU143_05280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HU143_05285	COG1121	(ABC) transporter
HU143_05305	COG0309	Hydrogenase expression formation protein (HypE)
HU143_05310	COG0409	Hydrogenase expression formation protein
HU143_05315	COG0298	carbon dioxide binding
HU143_05320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HU143_05335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_05340	COG0651	ATP synthesis coupled electron transport
HU143_05345	COG0650	Formate hydrogenlyase subunit 4
HU143_05350	COG3261	NADH dehydrogenase
HU143_05350	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HU143_05355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU143_05360	COG3260	NADH ubiquinone oxidoreductase 20
HU143_05370	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HU143_05380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_05385	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HU143_05410	COG1349	DNA-binding transcription factor activity
HU143_05415	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_05420	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_05430	COG3732	PTS system glucitol sorbitol-specific
HU143_05435	COG3730	PTS system glucitol sorbitol-specific
HU143_05440	COG2951	lytic endotransglycosylase activity
HU143_05445	COG1546	Belongs to the CinA family
HU143_05465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HU143_05495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU143_05500	COG1238	metal cluster binding
HU143_05520	COG2814	Major facilitator Superfamily
HU143_05525	COG1566	PFAM secretion protein HlyD family protein
HU143_05530	COG1846	Transcriptional regulator
HU143_05535	COG2814	Major facilitator Superfamily
HU143_05575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HU143_05585	COG4575	ribosome binding
HU143_05610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HU143_05615	COG0640	Transcriptional regulator
HU143_05620	COG0401	homolog of Blt101
HU143_05625	COG1652	LysM domain
HU143_05630	COG1802	Transcriptional regulator
HU143_05635	COG1113	amino acid transport
HU143_05640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HU143_05645	COG1012	belongs to the aldehyde dehydrogenase family
HU143_05650	COG0579	oxidoreductase
HU143_05685	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HU143_05695	COG2990	Protein conserved in bacteria
HU143_05715	COG2819	hydrolase of the alpha beta superfamily
HU143_05780	COG0582	viral genome integration into host DNA
HU143_05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_05815	COG2867	negative regulation of translational initiation
HU143_05830	COG0497	DNA recombination
HU143_05850	COG4536	flavin adenine dinucleotide binding
HU143_05855	COG4137	Cytochrome C assembly protein
HU143_05860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HU143_05885	COG2199	diguanylate cyclase activity
HU143_05900	COG1605	Chorismate mutase
HU143_05900	COG0287	Prephenate dehydrogenase
HU143_05910	COG0077	Prephenate dehydratase
HU143_05910	COG1605	Chorismate mutase
HU143_05920	COG4974	Belongs to the 'phage' integrase family
HU143_05960	COG4695	Portal protein
HU143_06050	COG5301	cellulose 1,4-beta-cellobiosidase activity
HU143_06080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HU143_06085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HU143_06100	COG0542	response to heat
HU143_06130	COG0477	Major facilitator Superfamily
HU143_06135	COG5544	Lipoprotein
HU143_06140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HU143_06150	COG3148	PFAM DTW domain containing protein
HU143_06155	COG3118	belongs to the thioredoxin family
HU143_06160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HU143_06180	COG0583	DNA-binding transcription factor activity
HU143_06185	COG0513	Belongs to the DEAD box helicase family
HU143_06220	COG3086	response to oxidative stress
HU143_06260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_06265	COG0583	DNA-binding transcription factor activity
HU143_06270	COG2223	nitrite transmembrane transporter activity
HU143_06275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HU143_06280	COG1737	Transcriptional regulator
HU143_06290	COG1263	PTS System
HU143_06290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HU143_06295	COG0560	Phosphoserine phosphatase
HU143_06320	COG2205	protein histidine kinase activity
HU143_06325	COG3170	Tfp pilus assembly protein FimV
HU143_06330	COG2204	response regulator
HU143_06335	COG0347	Belongs to the P(II) protein family
HU143_06340	COG3104	oligopeptide transport
HU143_06350	COG0531	amino acid
HU143_06355	COG3710	Transcriptional regulator
HU143_06365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HU143_06365	COG1017	nitric oxide dioxygenase activity
HU143_06375	COG2814	Major facilitator Superfamily
HU143_06380	COG3711	transcriptional antiterminator
HU143_06390	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HU143_06435	COG0822	iron-sulfur transferase activity
HU143_06455	COG0633	Ferredoxin
HU143_06460	COG2975	iron-sulfur cluster assembly
HU143_06480	COG2897	thiosulfate sulfurtransferase activity
HU143_06485	COG2373	Large extracellular alpha-helical protein
HU143_06490	COG4953	penicillin-binding protein 1C
HU143_06495	COG0243	molybdopterin cofactor binding
HU143_06500	COG0437	4 iron, 4 sulfur cluster binding
HU143_06540	COG2976	Protein conserved in bacteria
HU143_06555	COG1645	bacterial-type flagellum-dependent swarming motility
HU143_06595	COG0517	IMP dehydrogenase activity
HU143_06595	COG0516	GMP reductase activity
HU143_06620	COG3133	Outer membrane lipoprotein
HU143_06635	COG2200	EAL domain
HU143_06650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HU143_06665	COG2233	PERMEase
HU143_06675	COG1393	Belongs to the ArsC family
HU143_06685	COG0628	permease
HU143_06690	COG3835	regulator
HU143_06695	COG2610	gluconate transmembrane transporter activity
HU143_06700	COG1929	Belongs to the glycerate kinase type-1 family
HU143_06705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HU143_06710	COG2716	regulation of RNA biosynthetic process
HU143_06715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HU143_06720	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HU143_06730	COG2321	neutral zinc metallopeptidase
HU143_06750	COG1393	Belongs to the ArsC family
HU143_06760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HU143_06765	COG3850	Histidine kinase
HU143_06770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_06770	COG0493	'glutamate synthase
HU143_06785	COG5342	invasion associated locus B
HU143_06795	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HU143_06920	COG2837	iron assimilation
HU143_06940	COG4208	sulfate ABC transporter
HU143_06945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HU143_06990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_07015	COG3530	Putative quorum-sensing-regulated virulence factor
HU143_07020	COG0385	Bile acid
HU143_07025	COG0583	DNA-binding transcription factor activity
HU143_07035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HU143_07040	COG2211	Major facilitator Superfamily
HU143_07050	COG0583	DNA-binding transcription factor activity
HU143_07080	COG3415	Transposase
HU143_07085	COG3415	Transposase
HU143_07100	COG2200	EAL domain
HU143_07100	COG2199	diguanylate cyclase activity
HU143_07105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HU143_07120	COG0667	Aldo Keto reductase
HU143_07125	COG3961	Belongs to the TPP enzyme family
HU143_07145	COG0436	Aminotransferase
HU143_07155	COG1560	Kdo2-lipid A biosynthetic process
HU143_07210	COG2116	formate transmembrane transporter activity
HU143_07225	COG3691	Protein conserved in bacteria
HU143_07240	COG2062	phosphohistidine phosphatase, SixA
HU143_07265	COG0730	response to heat
HU143_07270	COG3101	peptidyl-lysine hydroxylation
HU143_07285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HU143_07325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HU143_07335	COG0586	Pfam SNARE associated Golgi protein
HU143_07345	COG0285	dihydrofolate synthase activity
HU143_07350	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HU143_07355	COG1286	toxin biosynthetic process
HU143_07360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HU143_07365	COG3829	transcription factor binding
HU143_07375	COG0531	amino acid
HU143_07380	COG3457	Alanine racemase
HU143_07385	COG0833	amino acid
HU143_07420	COG1090	epimerase
HU143_07425	COG0625	glutathione transferase activity
HU143_07430	COG0625	glutathione transferase activity
HU143_07435	COG0622	Phosphoesterase
HU143_07445	COG1609	Transcriptional regulator
HU143_07450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_07460	COG3037	sugar-specific permease SgaT UlaA
HU143_07465	COG3959	Transketolase, thiamine diphosphate binding domain
HU143_07470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HU143_07475	COG1288	antiporter activity
HU143_07500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU143_07505	COG0490	domain, Protein
HU143_07505	COG0471	metal ion transport
HU143_07515	COG0436	Aminotransferase
HU143_07520	COG0583	DNA-binding transcription factor activity
HU143_07570	COG0839	Belongs to the complex I subunit 6 family
HU143_07580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HU143_07585	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU143_07595	COG0784	Response regulator, receiver
HU143_07595	COG0835	chemotaxis
HU143_07605	COG2153	protein acetylation
HU143_07610	COG4575	ribosome binding
HU143_07615	COG1169	isochorismate synthase
HU143_07710	COG0247	lactate metabolic process
HU143_07720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HU143_07725	COG2271	Major facilitator Superfamily
HU143_07730	COG0584	glycerophosphoryl diester phosphodiesterase
HU143_07735	COG0583	DNA-binding transcription factor activity
HU143_07740	COG2814	Major facilitator Superfamily
HU143_07745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HU143_07775	COG4948	Mandelate Racemase Muconate Lactonizing
HU143_07795	COG2198	Histidine kinase
HU143_07795	COG0642	Histidine kinase
HU143_07820	COG4615	Cyclic peptide transporter
HU143_07830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_07830	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HU143_07835	COG3062	negative regulation of establishment of protein localization
HU143_07845	COG0437	4 iron, 4 sulfur cluster binding
HU143_07850	COG0348	domain, Protein
HU143_07855	COG3043	anaerobic respiration
HU143_07860	COG3005	denitrification pathway
HU143_07870	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HU143_07875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HU143_07880	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HU143_07890	COG1138	Cytochrome C-type biogenesis protein
HU143_07900	COG4235	cytochrome complex assembly
HU143_07900	COG3088	subunit of a heme lyase
HU143_07905	COG2197	response regulator
HU143_07970	COG1061	Type III restriction enzyme res subunit
HU143_07980	COG2814	Major facilitator Superfamily
HU143_07990	COG4172	Belongs to the ABC transporter superfamily
HU143_07995	COG4239	(ABC) transporter, permease
HU143_08000	COG4174	ABC transporter (Permease)
HU143_08005	COG4166	transmembrane transport
HU143_08010	COG2200	EAL domain
HU143_08015	COG0791	NLP P60 protein
HU143_08020	COG0671	phosphoesterase, PA-phosphatase related
HU143_08025	COG0523	cobalamin synthesis protein
HU143_08060	COG1105	Belongs to the carbohydrate kinase PfkB family
HU143_08065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HU143_08065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HU143_08065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HU143_08070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HU143_08075	COG2855	membrane
HU143_08080	COG0583	DNA-binding transcription factor activity
HU143_08085	COG0833	amino acid
HU143_08090	COG4771	TonB-dependent receptor
HU143_08095	COG2271	Major facilitator Superfamily
HU143_08100	COG0560	Phosphoserine phosphatase
HU143_08105	COG1760	l-serine dehydratase
HU143_08125	COG2311	Membrane
HU143_08165	COG2949	membrane
HU143_08175	COG1346	cytolysis
HU143_08190	COG2271	Major facilitator Superfamily
HU143_08205	COG0625	glutathione transferase activity
HU143_08210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HU143_08225	COG1538	Outer membrane efflux protein
HU143_08230	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_08235	COG0586	Pfam SNARE associated Golgi protein
HU143_08245	COG1686	Belongs to the peptidase S11 family
HU143_08250	COG0277	FAD linked oxidase domain protein
HU143_08260	COG1732	Glycine betaine
HU143_08265	COG1174	glycine betaine transport
HU143_08270	COG1125	glycine betaine transport
HU143_08275	COG1174	glycine betaine transport
HU143_08290	COG3275	phosphorelay sensor kinase activity
HU143_08300	COG4807	Protein conserved in bacteria
HU143_08310	COG4808	Protein conserved in bacteria
HU143_08335	COG3121	Chaperone
HU143_08340	COG3188	usher protein
HU143_08350	COG5455	response to cobalt ion
HU143_08365	COG2188	Transcriptional regulator
HU143_08370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_08375	COG1397	ADP-ribosylglycohydrolase
HU143_08380	COG2211	Major facilitator Superfamily
HU143_08385	COG1830	Aldolase
HU143_08410	COG0826	peptidase U32
HU143_08450	COG3209	COG3209 Rhs family protein
HU143_08455	COG3209	COG3209 Rhs family protein
HU143_08465	COG1413	lyase activity
HU143_08470	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HU143_08515	COG0745	RESPONSE REGULATOR receiver
HU143_08520	COG2205	protein histidine kinase activity
HU143_08550	COG0443	Heat shock 70 kDa protein
HU143_08555	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HU143_08560	COG5001	Diguanylate cyclase
HU143_08560	COG3447	MASE1 domain protein
HU143_08560	COG5002	protein histidine kinase activity
HU143_08575	COG2982	Protein involved in outer membrane biogenesis
HU143_08580	COG1253	flavin adenine dinucleotide binding
HU143_08600	COG0463	Glycosyl transferase, family 2
HU143_08605	COG1045	serine acetyltransferase
HU143_08610	COG0438	transferase activity, transferring glycosyl groups
HU143_08620	COG1216	Glycosyl transferase, family 2
HU143_08625	COG0110	maltose O-acetyltransferase activity
HU143_08630	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HU143_08635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU143_08645	COG0297	glycogen (starch) synthase activity
HU143_08660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HU143_08665	COG2244	polysaccharide biosynthetic process
HU143_08670	COG2327	Polysaccharide pyruvyl transferase
HU143_08715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HU143_08830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU143_08835	COG0583	DNA-binding transcription factor activity
HU143_08845	COG0531	amino acid
HU143_08850	COG2925	Exonuclease
HU143_08890	COG1289	transmembrane transporter activity
HU143_08925	COG4656	Part of a membrane complex involved in electron transport
HU143_08930	COG1454	alcohol dehydrogenase
HU143_08930	COG1012	belongs to the aldehyde dehydrogenase family
HU143_08945	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HU143_08960	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HU143_09020	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HU143_09090	COG1122	ATPase activity
HU143_09125	COG0534	Mate efflux family protein
HU143_09135	COG0582	viral genome integration into host DNA
HU143_09145	COG3423	Transcriptional regulator
HU143_09180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HU143_09185	COG2249	NAD(P)H dehydrogenase (quinone) activity
HU143_09190	COG1733	regulation of RNA biosynthetic process
HU143_09350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HU143_09360	COG0582	viral genome integration into host DNA
HU143_09390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HU143_09400	COG1418	mRNA catabolic process
HU143_09405	COG0270	DNA (cytosine-5-)-methyltransferase activity
HU143_09410	COG3727	T/G mismatch-specific endonuclease activity
HU143_09415	COG0697	spore germination
HU143_09420	COG2354	Protein conserved in bacteria
HU143_09425	COG5475	Uncharacterized small protein (DUF2158)
HU143_09530	COG0425	Belongs to the sulfur carrier protein TusA family
HU143_09585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HU143_09595	COG0765	amino acid transport
HU143_09600	COG1126	abc transporter atp-binding protein
HU143_09605	COG2197	response regulator
HU143_09620	COG2197	response regulator
HU143_09665	COG3318	Belongs to the UPF0149 family
HU143_09665	COG3012	SEC-C Motif Domain Protein
HU143_09670	COG0814	amino acid
HU143_09680	COG1528	Iron-storage protein
HU143_09695	COG1528	Iron-storage protein
HU143_09800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HU143_09815	COG3102	Protein conserved in bacteria
HU143_09835	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HU143_09840	COG1801	Protein of unknown function DUF72
HU143_09845	COG1335	isochorismatase
HU143_09855	COG0494	nUDIX hydrolase
HU143_09890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HU143_09895	COG1121	(ABC) transporter
HU143_09900	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HU143_09905	COG0739	heme binding
HU143_09910	COG1560	Kdo2-lipid A biosynthetic process
HU143_09920	COG1737	Transcriptional regulator
HU143_09925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HU143_09930	COG0129	dihydroxy-acid dehydratase activity
HU143_09935	COG0800	Aldolase
HU143_09945	COG3141	response to X-ray
HU143_09955	COG2979	Protein of unknown function (DUF533)
HU143_09960	COG1770	oligopeptidase
HU143_09965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HU143_09970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU143_09980	COG2372	response to copper ion
HU143_09985	COG1276	copper resistance
HU143_10060	COG5562	phage envelope protein
HU143_10095	COG3008	intermembrane lipid transfer
HU143_10100	COG2995	paraquat-inducible protein a
HU143_10105	COG1956	GAF domain-containing protein
HU143_10125	COG2814	Major facilitator Superfamily
HU143_10130	COG1414	Transcriptional regulator
HU143_10160	COG0768	penicillin binding
HU143_10165	COG2226	methyltransferase
HU143_10180	COG3716	PTS system mannose fructose sorbose family IID component
HU143_10185	COG3715	PTS system
HU143_10190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_10190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HU143_10195	COG1253	flavin adenine dinucleotide binding
HU143_10200	COG2200	EAL domain
HU143_10205	COG1760	l-serine dehydratase
HU143_10225	COG0251	oxidation-reduction process
HU143_10230	COG1199	ATP-dependent helicase activity
HU143_10240	COG3065	identical protein binding
HU143_10250	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HU143_10260	COG2894	cell division
HU143_10275	COG0179	Fumarylacetoacetate (FAA) hydrolase
HU143_10315	COG2719	SpoVR family
HU143_10335	COG1619	proteins homologs of microcin C7 resistance protein MccF
HU143_10360	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HU143_10370	COG1294	oxidase, subunit
HU143_10375	COG1271	oxidase subunit
HU143_10380	COG1773	rubredoxin
HU143_10385	COG1999	signal sequence binding
HU143_10390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HU143_10395	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HU143_10465	COG3423	Transcriptional regulator
HU143_10480	COG2003	Belongs to the UPF0758 family
HU143_10500	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HU143_10525	COG5290	Psort location Cytoplasmic, score
HU143_10565	COG2826	transposase and inactivated derivatives, IS30 family
HU143_10575	COG0582	viral genome integration into host DNA
HU143_10580	COG0012	GTP binding
HU143_10595	COG0659	secondary active sulfate transmembrane transporter activity
HU143_10645	COG0387	Pfam Sodium calcium exchanger
HU143_10650	COG4572	Cation transport regulator
HU143_10655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HU143_10660	COG4932	domain protein
HU143_10665	COG2197	response regulator
HU143_10670	COG3850	Histidine kinase
HU143_10675	COG2223	nitrite transmembrane transporter activity
HU143_10680	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HU143_10685	COG1140	nitrate reductase beta subunit
HU143_10690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HU143_10695	COG2181	nitrate reductase activity
HU143_10725	COG0788	formyltetrahydrofolate deformylase activity
HU143_10735	COG1752	Esterase of the alpha-beta hydrolase superfamily
HU143_10740	COG0745	RESPONSE REGULATOR receiver
HU143_10745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HU143_10760	COG1454	alcohol dehydrogenase
HU143_10760	COG1012	belongs to the aldehyde dehydrogenase family
HU143_10765	COG2095	MarC family integral membrane protein
HU143_10795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HU143_10815	COG2350	Protein conserved in bacteria
HU143_10840	COG0727	PFAM Uncharacterised protein family (UPF0153)
HU143_10850	COG3546	catalase activity
HU143_10855	COG3685	Protein conserved in bacteria
HU143_10860	COG3685	Protein conserved in bacteria
HU143_10865	COG3729	General stress protein
HU143_10905	COG0009	L-threonylcarbamoyladenylate synthase
HU143_10920	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_10925	COG0616	signal peptide processing
HU143_10965	COG0671	phosphoesterase, PA-phosphatase related
HU143_10970	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HU143_10975	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HU143_10995	COG1349	DNA-binding transcription factor activity
HU143_11005	COG5001	Diguanylate cyclase
HU143_11015	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HU143_11015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HU143_11110	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HU143_11115	COG1842	Phage shock protein A
HU143_11125	COG1983	PspC domain protein
HU143_11135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HU143_11140	COG3106	COG3106 Predicted ATPase
HU143_11160	COG4948	Mandelate Racemase Muconate Lactonizing
HU143_11165	COG2866	Carboxypeptidase
HU143_11170	COG4166	transmembrane transport
HU143_11180	COG0583	DNA-binding transcription factor activity
HU143_11185	COG0656	L-ascorbic acid biosynthetic process
HU143_11190	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_11195	COG1309	transcriptional regulator
HU143_11230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HU143_11250	COG0668	transmembrane transport
HU143_11255	COG3182	Iron-regulated membrane protein
HU143_11275	COG2840	Smr protein MutS2
HU143_11280	COG0840	transmembrane signaling receptor activity
HU143_11290	COG0513	Belongs to the DEAD box helicase family
HU143_11310	COG2076	Multidrug Resistance protein
HU143_11325	COG1013	pyruvate-flavodoxin oxidoreductase activity
HU143_11325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HU143_11325	COG0674	pyruvate-flavodoxin oxidoreductase activity
HU143_11325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HU143_11335	COG3042	response to heat
HU143_11340	COG3187	Heat shock protein
HU143_11345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HU143_11350	COG2911	Protein conserved in bacteria
HU143_11360	COG3784	Protein of unknown function (DUF1318)
HU143_11375	COG1643	Atp-dependent helicase
HU143_11380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HU143_11385	COG3038	cytochrome b561
HU143_11390	COG0500	methyltransferase
HU143_11400	COG0765	amino acid transport
HU143_11410	COG0765	amino acid transport
HU143_11415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HU143_11450	COG0840	transmembrane signaling receptor activity
HU143_11455	COG0583	DNA-binding transcription factor activity
HU143_11460	COG5383	Protein conserved in bacteria
HU143_11465	COG2272	Belongs to the type-B carboxylesterase lipase family
HU143_11470	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HU143_11475	COG2353	YceI-like domain
HU143_11480	COG1304	FMN binding
HU143_11490	COG1349	DNA-binding transcription factor activity
HU143_11495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HU143_11500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_11505	COG0434	BtpA family
HU143_11510	COG3775	system Galactitol-specific IIC component
HU143_11515	COG3414	Phosphotransferase system galactitol-specific IIB component
HU143_11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HU143_11530	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HU143_11535	COG1275	C4-dicarboxylate transporter malic acid transport protein
HU143_11540	COG0500	methyltransferase
HU143_11550	COG3135	benzoate transporter
HU143_11555	COG1396	sequence-specific DNA binding
HU143_11560	COG0826	peptidase U32
HU143_11585	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HU143_11590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HU143_11630	COG3238	Protein conserved in bacteria
HU143_11640	COG2130	NADP-dependent
HU143_11645	COG1802	Transcriptional regulator
HU143_11650	COG4772	TonB-dependent receptor
HU143_11655	COG3391	amine dehydrogenase activity
HU143_11685	COG2181	nitrate reductase activity
HU143_11690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HU143_11695	COG1140	nitrate reductase beta subunit
HU143_11700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HU143_11740	COG0437	4 iron, 4 sulfur cluster binding
HU143_11745	COG2864	formate dehydrogenase
HU143_11750	COG1064	alcohol dehydrogenase
HU143_11770	COG1764	response to oxidative stress
HU143_11795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HU143_11810	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HU143_11815	COG1757	Na H antiporter
HU143_11820	COG1609	Transcriptional regulator
HU143_11860	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HU143_11885	COG2271	Major facilitator Superfamily
HU143_11890	COG1063	alcohol dehydrogenase
HU143_11895	COG2186	Transcriptional regulator
HU143_11905	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HU143_11910	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HU143_11935	COG1773	rubredoxin
HU143_11960	COG3781	membrane
HU143_11975	COG1012	belongs to the aldehyde dehydrogenase family
HU143_11980	COG0583	DNA-binding transcription factor activity
HU143_12015	COG2814	Major facilitator Superfamily
HU143_12025	COG3111	PFAM Bacterial OB fold (BOF) protein
HU143_12030	COG1546	Belongs to the CinA family
HU143_12035	COG3729	General stress protein
HU143_12045	COG4221	oxidoreductase activity
HU143_12050	COG1802	Transcriptional regulator
HU143_12060	COG0246	Mannitol dehydrogenase
HU143_12065	COG0477	Major facilitator Superfamily
HU143_12070	COG1063	alcohol dehydrogenase
HU143_12090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HU143_12105	COG0243	molybdopterin cofactor binding
HU143_12110	COG0243	molybdopterin cofactor binding
HU143_12115	COG0437	4 iron, 4 sulfur cluster binding
HU143_12120	COG3302	dmso reductase anchor subunit
HU143_12160	COG1940	carbohydrate kinase activity
HU143_12165	COG0583	DNA-binding transcription factor activity
HU143_12170	COG2814	Major facilitator Superfamily
HU143_12180	COG3591	Belongs to the peptidase S1B family
HU143_12195	COG0628	permease
HU143_12200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HU143_12205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HU143_12215	COG0531	amino acid
HU143_12220	COG3136	membrane protein required for alginate biosynthesis
HU143_12225	COG0745	RESPONSE REGULATOR receiver
HU143_12230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HU143_12235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HU143_12240	COG2205	protein histidine kinase activity
HU143_12265	COG5339	Protein conserved in bacteria
HU143_12280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HU143_12285	COG0673	inositol 2-dehydrogenase activity
HU143_12335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HU143_12345	COG0625	glutathione transferase activity
HU143_12365	COG3895	Periplasmic Protein
HU143_12390	COG1566	PFAM secretion protein HlyD family protein
HU143_12405	COG4989	oxidoreductase activity
HU143_12410	COG3313	Fe-S protein
HU143_12415	COG1309	transcriptional regulator
HU143_12420	COG1902	pentaerythritol trinitrate reductase activity
HU143_12435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HU143_12440	COG0791	NLP P60 protein
HU143_12460	COG0583	DNA-binding transcription factor activity
HU143_12465	COG2814	Major facilitator Superfamily
HU143_12470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HU143_12475	COG0307	riboflavin synthase, alpha
HU143_12655	COG0789	Transcriptional regulator
HU143_12660	COG3272	Protein of unknown function (DUF1722)
HU143_12695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_12705	COG2267	carboxylic ester hydrolase activity
HU143_12710	COG0531	amino acid
HU143_12730	COG4238	major outer membrane lipoprotein
HU143_12735	COG1376	ErfK ybiS ycfS ynhG family protein
HU143_12750	COG0719	Fe-S assembly protein
HU143_12755	COG0396	ATPase activity
HU143_12760	COG0719	Fe-S assembly protein
HU143_12765	COG0316	Belongs to the HesB IscA family
HU143_12770	COG1823	symporter activity
HU143_12780	COG2050	protein possibly involved in aromatic compounds catabolism
HU143_12785	COG0277	FAD linked oxidase domain protein
HU143_12785	COG0247	lactate metabolic process
HU143_12790	COG0628	permease
HU143_12805	COG0738	Major facilitator superfamily
HU143_12810	COG2271	Major facilitator Superfamily
HU143_12825	COG4670	ketone body catabolic process
HU143_12830	COG1960	acyl-CoA dehydrogenase activity
HU143_12835	COG1917	Cupin 2, conserved barrel domain protein
HU143_12835	COG2207	Transcriptional regulator
HU143_12840	COG2086	electron transfer activity
HU143_12845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HU143_12850	COG0644	oxidoreductase
HU143_12855	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HU143_12860	COG0318	PFAM AMP-dependent synthetase and ligase
HU143_12865	COG0574	Belongs to the PEP-utilizing enzyme family
HU143_12865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HU143_12880	COG4256	Hemin uptake protein
HU143_12900	COG0791	NLP P60 protein
HU143_12910	COG0386	Belongs to the glutathione peroxidase family
HU143_12985	COG3137	Salt-induced outer membrane protein
HU143_12990	COG1105	Belongs to the carbohydrate kinase PfkB family
HU143_13000	COG3001	Fructosamine kinase
HU143_13010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU143_13015	COG1988	membrane-bound metal-dependent
HU143_13020	COG1823	symporter activity
HU143_13030	COG0753	catalase activity
HU143_13040	COG1486	melibiose metabolic process
HU143_13060	COG1447	Phosphotransferase system cellobiose-specific component IIA
HU143_13065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HU143_13070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HU143_13075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HU143_13090	COG3678	ATP-independent chaperone mediated protein folding
HU143_13125	COG0494	nUDIX hydrolase
HU143_13140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HU143_13150	COG0778	Nitroreductase
HU143_13155	COG0616	signal peptide processing
HU143_13160	COG0252	asparaginase activity
HU143_13165	COG1335	isochorismatase
HU143_13170	COG3139	Protein of unknown function (DUF1315)
HU143_13190	COG0656	L-ascorbic acid biosynthetic process
HU143_13195	COG0641	radical SAM
HU143_13200	COG3713	MltA-interacting MipA family protein
HU143_13205	COG2766	serine protein kinase
HU143_13220	COG2199	diguanylate cyclase activity
HU143_13225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HU143_13240	COG2207	Transcriptional regulator
HU143_13245	COG2807	transmembrane transport
HU143_13250	COG3189	MarR family transcriptional regulator
HU143_13260	COG3042	response to heat
HU143_13270	COG2261	transglycosylase associated protein
HU143_13285	COG3615	Tellurite resistance protein tehB
HU143_13295	COG1605	Chorismate mutase
HU143_13310	COG0789	Transcriptional regulator
HU143_13325	COG3443	Belongs to the bacterial solute-binding protein 9 family
HU143_13340	COG0668	transmembrane transport
HU143_13345	COG1124	(ABC) transporter
HU143_13375	COG3038	cytochrome b561
HU143_13385	COG0071	Belongs to the small heat shock protein (HSP20) family
HU143_13435	COG3021	interspecies interaction between organisms
HU143_13470	COG0538	isocitrate dehydrogenase activity
HU143_13500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HU143_13515	COG2850	peptidyl-arginine hydroxylation
HU143_13545	COG1177	transmembrane transport
HU143_13565	COG4591	ABC-type transport system involved in lipoprotein release permease component
HU143_13570	COG1136	(ABC) transporter
HU143_13575	COG4591	ABC-type transport system involved in lipoprotein release permease component
HU143_13580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HU143_13585	COG1388	LysM domain
HU143_13585	COG1376	ErfK ybiS ycfS ynhG family protein
HU143_13595	COG1309	transcriptional regulator
HU143_13600	COG3134	Outer membrane lipoprotein
HU143_13605	COG1252	NADH dehydrogenase
HU143_13630	COG5633	Lipoprotein
HU143_13635	COG0537	adenosine 5'-monophosphoramidase activity
HU143_13640	COG4773	Receptor
HU143_13650	COG0084	hydrolase, TatD family'
HU143_13655	COG0470	DNA polymerase III
HU143_13665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HU143_13670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HU143_13675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HU143_13695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HU143_13720	COG0564	pseudouridine synthase activity
HU143_13725	COG1530	ribonuclease E activity
HU143_13815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HU143_13825	COG2999	glutathione oxidoreductase activity
HU143_13860	COG3038	cytochrome b561
HU143_13875	COG1560	Kdo2-lipid A biosynthetic process
HU143_13890	COG5645	(Lipo)protein
HU143_13895	COG2943	transferase activity, transferring hexosyl groups
HU143_13910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HU143_13970	COG3381	protein complex oligomerization
HU143_14040	COG0673	inositol 2-dehydrogenase activity
HU143_14045	COG2814	Major facilitator Superfamily
HU143_14065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HU143_14070	COG1737	Transcriptional regulator
HU143_14075	COG1702	phosphate starvation-inducible protein PhoH
HU143_14095	COG1309	transcriptional regulator
HU143_14100	COG3729	General stress protein
HU143_14120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HU143_14125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HU143_14125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HU143_14130	COG4232	protein-disulfide reductase activity
HU143_14175	COG3971	2-oxopent-4-enoate hydratase activity
HU143_14185	COG3384	dioxygenase
HU143_14190	COG1012	belongs to the aldehyde dehydrogenase family
HU143_14200	COG1846	Transcriptional regulator
HU143_14205	COG2368	4-hydroxyphenylacetate
HU143_14220	COG0745	RESPONSE REGULATOR receiver
HU143_14225	COG2205	protein histidine kinase activity
HU143_14275	COG0670	Belongs to the BI1 family
HU143_14295	COG1881	PFAM PEBP family protein
HU143_14310	COG1832	CoA-binding protein
HU143_14325	COG0210	DNA helicase
HU143_14330	COG3304	Inner membrane component domain
HU143_14335	COG1289	transmembrane transporter activity
HU143_14340	COG3070	regulator of competence-specific genes
HU143_14360	COG1067	ATP-dependent peptidase activity
HU143_14370	COG3130	regulation of translation
HU143_14375	COG3009	Protein conserved in bacteria
HU143_14380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HU143_14380	COG3008	intermembrane lipid transfer
HU143_14385	COG2995	paraquat-inducible protein a
HU143_14390	COG0488	(ABC) transporter
HU143_14400	COG0633	Ferredoxin
HU143_14400	COG3217	Mosc domain protein beta barrel domain protein
HU143_14415	COG0308	aminopeptidase N
HU143_14425	COG0017	Asparaginyl-tRNA synthetase
HU143_14430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HU143_14435	COG1448	Aminotransferase
HU143_14440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HU143_14445	COG3108	Peptidase M15
HU143_14450	COG2989	Protein conserved in bacteria
HU143_14460	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HU143_14470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HU143_14475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HU143_14480	COG3173	Aminoglycoside phosphotransferase
HU143_14495	COG3214	Protein conserved in bacteria
HU143_14510	COG2333	competence protein COMEC
HU143_14510	COG0658	competence protein
HU143_14520	COG0539	negative regulation of cytoplasmic translation
HU143_14530	COG0501	Belongs to the peptidase M48B family
HU143_14545	COG2323	membrane
HU143_14550	COG1944	ATP diphosphatase activity
HU143_14555	COG2116	formate transmembrane transporter activity
HU143_14560	COG1882	Formate acetyltransferase
HU143_14575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HU143_14580	COG0531	amino acid
HU143_14590	COG3302	dmso reductase anchor subunit
HU143_14595	COG0437	4 iron, 4 sulfur cluster binding
HU143_14600	COG0243	molybdopterin cofactor binding
HU143_14610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HU143_14630	COG0492	ferredoxin-NADP+ reductase activity
HU143_14635	COG4988	ABC transporter
HU143_14640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HU143_14660	COG0583	DNA-binding transcription factor activity
HU143_14670	COG1335	isochorismatase
HU143_14690	COG0542	response to heat
HU143_14700	COG1278	Cold shock
HU143_14705	COG1136	(ABC) transporter
HU143_14705	COG0577	efflux transmembrane transporter activity
HU143_14710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_14715	COG2990	Protein conserved in bacteria
HU143_14720	COG3593	DNA synthesis involved in DNA repair
HU143_14725	COG2431	L-lysine efflux transmembrane transporter activity
HU143_14735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HU143_14740	COG0028	Belongs to the TPP enzyme family
HU143_14745	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HU143_14750	COG0702	epimerase
HU143_14755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HU143_14760	COG3023	N-Acetylmuramoyl-L-alanine amidase
HU143_14775	COG1126	abc transporter atp-binding protein
HU143_14780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HU143_14785	COG4215	(ABC) transporter
HU143_14790	COG4160	amino acid transport
HU143_14795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HU143_14825	COG1177	transmembrane transport
HU143_14830	COG1176	ABC-type spermidine putrescine transport system, permease component I
HU143_14835	COG3842	ATPase activity
HU143_14840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HU143_14880	COG3226	Transcriptional regulator
HU143_14885	COG0738	Major facilitator superfamily
HU143_14890	COG0561	phosphatase activity
HU143_14895	COG2814	Major facilitator Superfamily
HU143_14900	COG0671	phosphoesterase, PA-phosphatase related
HU143_14905	COG1349	DNA-binding transcription factor activity
HU143_14910	COG1686	Belongs to the peptidase S11 family
HU143_14915	COG0625	glutathione transferase activity
HU143_14920	COG2133	pyrroloquinoline quinone binding
HU143_14945	COG0747	negative chemotaxis
HU143_14970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HU143_14975	COG1882	Formate acetyltransferase
HU143_14980	COG0561	phosphatase activity
HU143_14990	COG0488	(ABC) transporter
HU143_14995	COG1376	ErfK ybiS ycfS ynhG family protein
HU143_15000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HU143_15015	COG2194	sulfuric ester hydrolase activity
HU143_15020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HU143_15035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HU143_15040	COG0765	amino acid transport
HU143_15045	COG1126	abc transporter atp-binding protein
HU143_15050	COG0668	transmembrane transport
HU143_15060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HU143_15070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HU143_15080	COG0513	Belongs to the DEAD box helicase family
HU143_15085	COG1309	transcriptional regulator
HU143_15090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_15095	COG1131	(ABC) transporter
HU143_15100	COG0842	Transport permease protein
HU143_15105	COG0842	Transport permease protein
HU143_15115	COG3568	Endonuclease Exonuclease Phosphatase
HU143_15120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HU143_15125	COG0392	lysyltransferase activity
HU143_15140	COG0670	Belongs to the BI1 family
HU143_15150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HU143_15160	COG0521	Mo-molybdopterin cofactor biosynthetic process
HU143_15185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HU143_15210	COG1881	PFAM PEBP family protein
HU143_15240	COG4677	pectinesterase activity
HU143_15250	COG0561	phosphatase activity
HU143_15260	COG4149	molybdate abc transporter
HU143_15265	COG0725	ABC transporter, periplasmic molybdate-binding protein
HU143_15275	COG2005	Transcriptional regulator
HU143_15275	COG3585	molybdate ion transport
HU143_15280	COG1119	ATPase activity
HU143_15305	COG2017	converts alpha-aldose to the beta-anomer
HU143_15315	COG1120	ATPase activity
HU143_15320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HU143_15330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HU143_15335	COG5016	pyruvate
HU143_15335	COG0511	ligase activity, forming carbon-carbon bonds
HU143_15345	COG0471	metal ion transport
HU143_15345	COG0490	domain, Protein
HU143_15350	COG0583	DNA-binding transcription factor activity
HU143_15355	COG0583	DNA-binding transcription factor activity
HU143_15365	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HU143_15365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HU143_15370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HU143_15380	COG1230	cation diffusion facilitator family transporter
HU143_15425	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HU143_15430	COG2885	chlorophyll binding
HU143_15440	COG3064	Membrane
HU143_15445	COG0848	biopolymer transport protein
HU143_15450	COG0811	peptide transport
HU143_15455	COG0824	Thioesterase
HU143_15460	COG3790	cyd operon protein YbgE
HU143_15465	COG4890	Cyd operon protein YbgT
HU143_15470	COG1294	oxidase, subunit
HU143_15475	COG1271	oxidase subunit
HU143_15480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HU143_15490	COG0508	dehydrogenase complex catalyzes the overall conversion of
HU143_15495	COG0567	Dehydrogenase, E1 component
HU143_15510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HU143_15530	COG3180	Ammonia monooxygenase
HU143_15545	COG1984	allophanate hydrolase subunit 2
HU143_15550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HU143_15595	COG2205	protein histidine kinase activity
HU143_15600	COG0745	RESPONSE REGULATOR receiver
HU143_15610	COG1982	Orn Lys Arg decarboxylase major
HU143_15615	COG0531	amino acid
HU143_15625	COG0033	Phosphoglucomutase
HU143_15635	COG0596	Alpha beta hydrolase
HU143_15655	COG0735	belongs to the Fur family
HU143_15660	COG0583	DNA-binding transcription factor activity
HU143_15665	COG1053	succinate dehydrogenase
HU143_15705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HU143_15710	COG1846	Transcriptional regulator
HU143_15710	COG1940	carbohydrate kinase activity
HU143_15715	COG0647	UMP catabolic process
HU143_15720	COG0367	asparagine synthase
HU143_15760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HU143_15770	COG1702	phosphate starvation-inducible protein PhoH
HU143_15795	COG0765	amino acid transport
HU143_15800	COG0765	amino acid transport
HU143_15805	COG1126	abc transporter atp-binding protein
HU143_15820	COG2888	peptidyl-tyrosine sulfation
HU143_15825	COG3290	protein histidine kinase activity
HU143_15825	COG3829	transcription factor binding
HU143_15855	COG1466	dna polymerase III delta subunit
HU143_15865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HU143_15875	COG0799	negative regulation of ribosome biogenesis
HU143_15885	COG0768	penicillin binding
HU143_15890	COG0772	Belongs to the SEDS family
HU143_15895	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HU143_15900	COG1686	Belongs to the peptidase S11 family
HU143_15915	COG0583	DNA-binding transcription factor activity
HU143_15930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU143_15950	COG3069	C4-dicarboxylate transmembrane transporter activity
HU143_15955	COG4565	transcriptional regulatory protein
HU143_15960	COG3290	protein histidine kinase activity
HU143_15965	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HU143_15975	COG2301	Belongs to the HpcH HpaI aldolase family
HU143_15980	COG3051	citrate lyase alpha subunit
HU143_15995	COG0471	metal ion transport
HU143_16000	COG3719	Belongs to the RNase T2 family
HU143_16005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HU143_16010	COG1063	alcohol dehydrogenase
HU143_16030	COG0243	molybdopterin cofactor binding
HU143_16050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HU143_16055	COG0583	DNA-binding transcription factor activity
HU143_16060	COG3969	phosphoadenosine phosphosulfate
HU143_16065	COG1475	DNA binding
HU143_16070	COG0436	Aminotransferase
HU143_16075	COG0371	Dehydrogenase
HU143_16080	COG2879	small protein
HU143_16085	COG1966	Carbon starvation protein
HU143_16095	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_16100	COG1535	isochorismatase
HU143_16100	COG3433	isochorismatase activity
HU143_16105	COG1021	2,3-dihydroxybenzoate-AMP ligase
HU143_16110	COG1169	isochorismate synthase
HU143_16115	COG4592	Periplasmic binding protein
HU143_16125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HU143_16130	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HU143_16135	COG1120	ATPase activity
HU143_16140	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HU143_16145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HU143_16145	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HU143_16150	COG3251	PFAM MbtH domain protein
HU143_16155	COG2382	esterase
HU143_16160	COG4771	TonB-dependent receptor
HU143_16165	COG2977	Belongs to the P-Pant transferase superfamily
HU143_16190	COG2315	Protein conserved in bacteria
HU143_16205	COG0668	transmembrane transport
HU143_16210	COG1113	amino acid transport
HU143_16220	COG3059	membrane
HU143_16230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HU143_16235	COG2207	Transcriptional regulator
HU143_16255	COG2246	polysaccharide biosynthetic process
HU143_16260	COG0463	Glycosyl transferase, family 2
HU143_16340	COG2501	S4 domain
HU143_16345	COG1988	membrane-bound metal-dependent
HU143_16365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HU143_16375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HU143_16380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HU143_16385	COG0549	Belongs to the carbamate kinase family
HU143_16395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HU143_16400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HU143_16405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HU143_16410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HU143_16415	COG3257	ureidoglycine aminohydrolase activity
HU143_16420	COG1929	Belongs to the glycerate kinase type-1 family
HU143_16445	COG1953	Uracil, thiamine, allantoin
HU143_16455	COG2084	Dehydrogenase
HU143_16460	COG3622	Belongs to the hyi family
HU143_16465	COG3960	tartronate-semialdehyde synthase activity
HU143_16500	COG1464	Belongs to the NlpA lipoprotein family
HU143_16510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HU143_16515	COG4181	ATPase activity
HU143_16520	COG2755	lipolytic protein G-D-S-L family
HU143_16525	COG0300	oxidoreductase activity
HU143_16530	COG3118	belongs to the thioredoxin family
HU143_16535	COG0390	transport system, permease component
HU143_16540	COG4619	ABC transporter
HU143_16545	COG0330	HflC and HflK could
HU143_16550	COG1585	Membrane protein implicated in regulation of membrane protease activity
HU143_16560	COG2217	Heavy metal translocating P-type atpase
HU143_16570	COG3735	TraB family
HU143_16585	COG2223	nitrite transmembrane transporter activity
HU143_16590	COG4651	solute:proton antiporter activity
HU143_16590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HU143_16595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_16640	COG2832	Protein of unknown function (DUF454)
HU143_16645	COG3923	Primosomal replication protein n
HU143_16655	COG5464	transposase or invertase
HU143_16660	COG1196	nuclear chromosome segregation
HU143_16660	COG3264	Mechanosensitive ion channel
HU143_16665	COG1309	transcriptional regulator
HU143_16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_16675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HU143_16690	COG0110	maltose O-acetyltransferase activity
HU143_16710	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HU143_16720	COG3695	enzyme binding
HU143_16725	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HU143_16730	COG1946	Acyl-CoA thioesterase
HU143_16735	COG0004	ammonium transporteR
HU143_16740	COG0347	Belongs to the P(II) protein family
HU143_16745	COG1132	(ABC) transporter
HU143_16750	COG1132	(ABC) transporter
HU143_16755	COG1522	sequence-specific DNA binding
HU143_16770	COG4533	DNA binding
HU143_16780	COG0824	Thioesterase
HU143_16785	COG1555	photosystem II stabilization
HU143_16790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HU143_16800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HU143_16820	COG0271	Belongs to the BolA IbaG family
HU143_16825	COG3056	Lipoprotein
HU143_16830	COG2223	nitrite transmembrane transporter activity
HU143_16835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HU143_16840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HU143_16845	COG1845	cytochrome c oxidase, subunit III
HU143_16850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HU143_16870	COG2814	Major facilitator Superfamily
HU143_16900	COG2188	Transcriptional regulator
HU143_16935	COG0142	geranyltranstransferase activity
HU143_16945	COG0667	Aldo Keto reductase
HU143_16950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HU143_16970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HU143_16970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HU143_16980	COG4238	major outer membrane lipoprotein
HU143_17010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HU143_17020	COG1862	Preprotein translocase
HU143_17040	COG0450	alkyl hydroperoxide reductase
HU143_17050	COG0366	Alpha amylase catalytic
HU143_17065	COG5002	protein histidine kinase activity
HU143_17075	COG0420	3'-5' exonuclease activity
HU143_17080	COG0419	ATPase involved in DNA repair
HU143_17085	COG2814	Major facilitator Superfamily
HU143_17090	COG1940	carbohydrate kinase activity
HU143_17105	COG4126	flavin adenine dinucleotide binding
HU143_17125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HU143_17130	COG3706	GGDEF domain
HU143_17175	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HU143_17180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HU143_17205	COG0113	porphobilinogen synthase activity
HU143_17240	COG1280	lysine exporter protein (LysE YggA)
HU143_17260	COG1294	oxidase, subunit
HU143_17265	COG1271	oxidase subunit
HU143_17285	COG2814	Major facilitator Superfamily
HU143_17295	COG0789	Transcriptional regulator
HU143_17350	COG2200	EAL domain
HU143_17365	COG3539	Fimbrial protein
HU143_17370	COG3121	Chaperone
HU143_17375	COG3188	usher protein
HU143_17430	COG2195	Cleaves the N-terminal amino acid of tripeptides
HU143_17435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HU143_17440	COG1690	Belongs to the RtcB family
HU143_17450	COG3034	peptidoglycan biosynthetic process
HU143_17455	COG0121	glutamine amidotransferase
HU143_17475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HU143_17505	COG1522	sequence-specific DNA binding
HU143_17650	COG2885	chlorophyll binding
HU143_17650	COG3047	cAMP biosynthetic process
HU143_17760	COG2226	methyltransferase
HU143_17770	COG0741	lytic transglycosylase activity
HU143_17770	COG1388	LysM domain
HU143_17775	COG2226	methyltransferase
HU143_17785	COG2814	Major facilitator Superfamily
HU143_17790	COG0583	DNA-binding transcription factor activity
HU143_17795	COG0656	L-ascorbic acid biosynthetic process
HU143_17830	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HU143_17855	COG1720	tRNA m6t6A37 methyltransferase activity
HU143_17865	COG3015	lipoprotein NlpE involved in copper resistance
HU143_17870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HU143_17885	COG4568	rho-dependent transcription termination
HU143_17895	COG0346	lactoylglutathione lyase activity
HU143_17900	COG1982	Orn Lys Arg decarboxylase major
HU143_17960	COG0575	Belongs to the CDS family
HU143_18010	COG0477	Major facilitator Superfamily
HU143_18020	COG3835	regulator
HU143_18040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HU143_18045	COG2860	membrane
HU143_18075	COG3539	Fimbrial protein
HU143_18080	COG3539	Fimbrial protein
HU143_18085	COG3121	Chaperone
HU143_18090	COG3188	usher protein
HU143_18105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HU143_18110	COG1120	ATPase activity
HU143_18115	COG4774	siderophore transport
HU143_18120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HU143_18125	COG1643	Atp-dependent helicase
HU143_18130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HU143_18155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HU143_18180	COG3121	Chaperone
HU143_18185	COG3188	usher protein
HU143_18190	COG3539	Fimbrial protein
HU143_18210	COG0726	polysaccharide deacetylase
HU143_18215	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_18220	COG0842	Transport permease protein
HU143_18225	COG1131	(ABC) transporter
HU143_18230	COG0288	reversible hydration of carbon dioxide
HU143_18240	COG4993	Dehydrogenase
HU143_18245	COG2132	Multicopper oxidase
HU143_18265	COG1349	DNA-binding transcription factor activity
HU143_18295	COG3064	Membrane
HU143_18310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HU143_18315	COG0508	dehydrogenase complex catalyzes the overall conversion of
HU143_18320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HU143_18335	COG2211	Major facilitator Superfamily
HU143_18340	COG3940	Belongs to the glycosyl hydrolase 43 family
HU143_18345	COG3725	Membrane protein required for beta-lactamase induction
HU143_18360	COG4969	Belongs to the N-Me-Phe pilin family
HU143_18365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HU143_18370	COG1459	type II secretion system
HU143_18405	COG0494	nUDIX hydrolase
HU143_18425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HU143_18430	COG0849	cell division
HU143_18455	COG0772	Belongs to the SEDS family
HU143_18470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HU143_18480	COG0768	penicillin binding
HU143_18580	COG0586	Pfam SNARE associated Golgi protein
HU143_18620	COG0417	DNA replication proofreading
HU143_18640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HU143_18650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HU143_18685	COG3119	arylsulfatase activity
HU143_18705	COG2271	Major facilitator Superfamily
HU143_18715	COG0644	oxidoreductase
HU143_18825	COG5016	pyruvate
HU143_18825	COG0511	ligase activity, forming carbon-carbon bonds
HU143_18830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HU143_18860	COG1047	Peptidyl-prolyl cis-trans
HU143_18875	COG0196	riboflavin kinase activity
HU143_18900	COG0583	DNA-binding transcription factor activity
HU143_18920	COG0641	radical SAM
HU143_18925	COG3119	arylsulfatase activity
HU143_18935	COG0737	Belongs to the 5'-nucleotidase family
HU143_18970	COG3121	Chaperone
HU143_18975	COG3539	Fimbrial protein
HU143_18990	COG3188	usher protein
HU143_19055	COG4735	regulation of single-species biofilm formation
HU143_19060	COG1584	GPR1 FUN34 yaaH family protein
HU143_19065	COG0521	Mo-molybdopterin cofactor biosynthetic process
HU143_19075	COG1115	amino acid carrier protein
HU143_19085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HU143_19095	COG0460	homoserine dehydrogenase
HU143_19095	COG0527	aspartate kinase activity
HU143_19105	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HU143_19115	COG0745	RESPONSE REGULATOR receiver
HU143_19135	COG3121	Chaperone
HU143_19155	COG4452	Inner membrane protein CreD
HU143_19160	COG2205	protein histidine kinase activity
HU143_19165	COG0745	RESPONSE REGULATOR receiver
HU143_19170	COG3045	CreA protein
HU143_19175	COG2207	Transcriptional regulator
HU143_19175	COG3708	Transcriptional regulator
HU143_19200	COG0488	(ABC) transporter
HU143_19215	COG0560	Phosphoserine phosphatase
HU143_19220	COG3726	membrane protein affecting hemolysin expression
HU143_19255	COG1328	CTP reductase activity
HU143_19260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HU143_19265	COG0084	hydrolase, TatD family'
HU143_19270	COG4667	esterase of the alpha-beta hydrolase superfamily
HU143_19280	COG2823	Periplasmic or secreted lipoprotein
HU143_19290	COG1011	Hydrolase
HU143_19300	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HU143_19330	COG3706	GGDEF domain
HU143_19335	COG4114	ferric iron reductase
HU143_19340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HU143_19345	COG2197	response regulator
HU143_19350	COG2197	response regulator
HU143_19355	COG2966	Psort location CytoplasmicMembrane, score
HU143_19370	COG1484	DNA-dependent DNA replication
HU143_19385	COG0840	transmembrane signaling receptor activity
HU143_19390	COG1966	Carbon starvation protein
HU143_19395	COG2879	small protein
HU143_19400	COG0523	cobalamin synthesis protein
HU143_19410	COG1280	lysine exporter protein (LysE YggA)
HU143_19415	COG3586	endonuclease activity
HU143_19430	COG1012	belongs to the aldehyde dehydrogenase family
HU143_19435	COG5464	transposase or invertase
HU143_19445	COG2733	membrane
HU143_19450	COG0477	Major facilitator Superfamily
HU143_19455	COG3366	ferrous iron transmembrane transporter activity
HU143_19460	COG0700	Nucleoside recognition
HU143_19465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HU143_19470	COG0583	DNA-binding transcription factor activity
HU143_19490	COG2186	Transcriptional regulator
HU143_19495	COG0412	Dienelactone hydrolase
HU143_19520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HU143_19590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HU143_19595	COG0464	growth
HU143_19600	COG1404	Belongs to the peptidase S8 family
HU143_19605	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HU143_19615	COG0582	viral genome integration into host DNA
HU143_19625	COG1064	alcohol dehydrogenase
HU143_19630	COG3265	gluconokinase activity
HU143_19635	COG1063	alcohol dehydrogenase
HU143_19640	COG1028	Short-chain dehydrogenase reductase Sdr
HU143_19645	COG2610	gluconate transmembrane transporter activity
HU143_19650	COG1609	Transcriptional regulator
HU143_19655	COG0795	lipopolysaccharide-transporting ATPase activity
HU143_19660	COG0795	lipopolysaccharide-transporting ATPase activity
HU143_19670	COG2927	DNA polymerase III (CHI subunit)
HU143_19715	COG2731	YhcH YjgK YiaL family protein
HU143_19735	COG1288	antiporter activity
HU143_19740	COG1438	arginine binding
HU143_19785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HU143_19785	COG1263	PTS System
HU143_19790	COG0366	Alpha amylase catalytic
HU143_19805	COG2026	Addiction module toxin, RelE StbE family
HU143_19810	COG3077	Addiction module antitoxin, RelB DinJ family
HU143_19815	COG3711	transcriptional antiterminator
HU143_19815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HU143_19830	COG3964	amidohydrolase
HU143_19865	COG0312	modulator of DNA gyrase
HU143_19875	COG1082	Xylose isomerase domain protein TIM barrel
HU143_19885	COG2814	Major facilitator Superfamily
HU143_19890	COG0673	inositol 2-dehydrogenase activity
HU143_19895	COG3962	Belongs to the TPP enzyme family
HU143_19900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_19910	COG1082	Xylose isomerase domain protein TIM barrel
HU143_19915	COG5520	Belongs to the glycosyl hydrolase 30 family
HU143_19945	COG3718	enzyme involved in inositol metabolism
HU143_19950	COG0477	Major facilitator Superfamily
HU143_19950	COG2814	Major facilitator Superfamily
HU143_19955	COG2814	Major facilitator Superfamily
HU143_19955	COG0477	Major facilitator Superfamily
HU143_19960	COG1737	Transcriptional regulator
HU143_19960	COG0837	glucose binding
HU143_19965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HU143_19980	COG3964	amidohydrolase
HU143_19985	COG2271	Major facilitator Superfamily
HU143_19990	COG2105	PFAM AIG2 family protein
HU143_20010	COG1253	flavin adenine dinucleotide binding
HU143_20020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HU143_20035	COG1733	regulation of RNA biosynthetic process
HU143_20040	COG0702	epimerase
HU143_20045	COG0697	spore germination
HU143_20055	COG1113	amino acid transport
HU143_20060	COG0545	Peptidyl-prolyl cis-trans isomerase
HU143_20065	COG3061	Opacity-associated protein A
HU143_20080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HU143_20145	COG1073	alpha beta
HU143_20150	COG3650	response to hydrogen peroxide
HU143_20160	COG1960	acyl-CoA dehydrogenase activity
HU143_20165	COG0754	glutathionylspermidine amidase activity
HU143_20170	COG5463	Belongs to the UPF0441 family
HU143_20175	COG3766	membrane
HU143_20185	COG1842	Phage shock protein A
HU143_20190	COG3789	protein conserved in bacteria
HU143_20200	COG0557	exoribonuclease II activity
HU143_20215	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HU143_20220	COG0330	HflC and HflK could
HU143_20225	COG0330	HflC and HflK could
HU143_20230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HU143_20255	COG0802	atpase or kinase
HU143_20260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HU143_20260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HU143_20285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HU143_20305	COG3264	Mechanosensitive ion channel
HU143_20305	COG1511	domain protein
HU143_20325	COG1053	succinate dehydrogenase
HU143_20330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HU143_20360	COG5510	response to toxic substance
HU143_20400	COG0531	amino acid
HU143_20405	COG3030	protein affecting phage T7 exclusion by the F plasmid
HU143_20410	COG1027	Aspartate ammonia-lyase
HU143_20415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HU143_20430	COG1309	transcriptional regulator
HU143_20445	COG0671	phosphoesterase, PA-phosphatase related
HU143_20475	COG2197	response regulator
HU143_20500	COG3381	protein complex oligomerization
HU143_20505	COG3302	dmso reductase anchor subunit
HU143_20510	COG0437	4 iron, 4 sulfur cluster binding
HU143_20515	COG0243	molybdopterin cofactor binding
HU143_20520	COG3290	protein histidine kinase activity
HU143_20525	COG4565	transcriptional regulatory protein
HU143_20535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HU143_20540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HU143_20540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HU143_20555	COG2169	Transcriptional regulator
HU143_20560	COG1982	Orn Lys Arg decarboxylase major
HU143_20565	COG2207	Transcriptional regulator
HU143_20570	COG0531	amino acid
HU143_20600	COG2824	Alkylphosphonate utilization operon protein PhnA
HU143_20605	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HU143_20625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HU143_20635	COG1301	dicarboxylic acid transport
HU143_20640	COG4235	cytochrome complex assembly
HU143_20645	COG3088	subunit of a heme lyase
HU143_20650	COG1138	Cytochrome C-type biogenesis protein
HU143_20655	COG3301	Polysulphide reductase, NrfD
HU143_20660	COG0437	4 iron, 4 sulfur cluster binding
HU143_20665	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HU143_20675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HU143_20680	COG3162	membrane
HU143_20690	COG1346	cytolysis
HU143_20695	COG1380	Effector of murein hydrolase LrgA
HU143_20700	COG0583	DNA-binding transcription factor activity
HU143_20705	COG0025	NhaP-type Na H and K H
HU143_20710	COG2252	PERMEase
HU143_20730	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HU143_20790	COG2315	Protein conserved in bacteria
HU143_20800	COG3700	Belongs to the class B bacterial acid phosphatase family
HU143_20840	COG0735	belongs to the Fur family
HU143_20855	COG0534	Mate efflux family protein
HU143_20865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HU143_20910	COG3833	ABC-type maltose transport systems, permease component
HU143_20920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HU143_20945	COG0527	aspartate kinase activity
HU143_20960	COG0561	phosphatase activity
HU143_20965	COG1349	DNA-binding transcription factor activity
HU143_20980	COG3122	Protein conserved in bacteria
HU143_21025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HU143_21065	COG0151	Belongs to the GarS family
HU143_21070	COG2204	response regulator
HU143_21130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HU143_21135	COG2104	thiamine diphosphate biosynthetic process
HU143_21195	COG0250	Participates in transcription elongation, termination and antitermination
HU143_21245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HU143_21305	COG0583	DNA-binding transcription factor activity
HU143_21345	COG2207	Transcriptional regulator
HU143_21355	COG0371	Dehydrogenase
HU143_21360	COG3738	Protein conserved in bacteria
HU143_21380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HU143_21385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HU143_21390	COG0737	Belongs to the 5'-nucleotidase family
HU143_21405	COG0668	transmembrane transport
HU143_21410	COG0527	aspartate kinase activity
HU143_21410	COG0460	homoserine dehydrogenase
HU143_21415	COG0626	cystathionine gamma-synthase activity
HU143_21440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HU143_21445	COG1609	Transcriptional regulator
HU143_21450	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HU143_21465	COG1575	Belongs to the MenA family. Type 1 subfamily
HU143_21480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HU143_21490	COG1494	fructose-1,6-bisphosphatase
HU143_21500	COG3152	Membrane
HU143_21520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HU143_21535	COG2211	Major facilitator Superfamily
HU143_21560	COG3678	ATP-independent chaperone mediated protein folding
HU143_21565	COG0745	RESPONSE REGULATOR receiver
HU143_21570	COG2205	protein histidine kinase activity
HU143_21580	COG2258	MOSC domain
HU143_21595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HU143_21640	COG1454	alcohol dehydrogenase
HU143_21655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HU143_21685	COG0437	4 iron, 4 sulfur cluster binding
HU143_21690	COG2864	formate dehydrogenase
HU143_21705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HU143_21715	COG4680	protein conserved in bacteria
HU143_21720	COG5499	transcription regulator containing HTH domain
HU143_21725	COG0456	acetyltransferase
HU143_21740	COG1011	Hydrolase
HU143_21745	COG1349	DNA-binding transcription factor activity
HU143_21750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_21760	COG3684	Belongs to the aldolase LacD family
HU143_21770	COG2017	converts alpha-aldose to the beta-anomer
HU143_21775	COG1501	Belongs to the glycosyl hydrolase 31 family
HU143_21820	COG0561	phosphatase activity
HU143_21875	COG0204	Acyl-transferase
HU143_21890	COG3084	Protein conserved in bacteria
HU143_21900	COG1763	Mo-molybdopterin cofactor biosynthetic process
HU143_21945	COG1739	Uncharacterized protein family UPF0029
HU143_21975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HU143_21990	COG0805	protein transport
HU143_21995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HU143_22035	COG0641	radical SAM
HU143_22055	COG0561	phosphatase activity
HU143_22060	COG2267	carboxylic ester hydrolase activity
HU143_22065	COG1280	lysine exporter protein (LysE YggA)
HU143_22070	COG1280	lysine exporter protein (LysE YggA)
HU143_22115	COG1011	Hydrolase
HU143_22120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HU143_22175	COG2959	enzyme of heme biosynthesis
HU143_22180	COG3071	HemY protein
HU143_22230	COG2244	polysaccharide biosynthetic process
HU143_22235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HU143_22240	COG0456	acetyltransferase
HU143_22245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HU143_22245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HU143_22250	COG1088	dTDP-glucose 4,6-dehydratase activity
HU143_22255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HU143_22285	COG3118	belongs to the thioredoxin family
HU143_22355	COG3978	acetolactate synthase activity
HU143_22420	COG2186	Transcriptional regulator
HU143_22425	COG0477	Major facilitator Superfamily
HU143_22430	COG1609	Transcriptional regulator
HU143_22435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HU143_22445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HU143_22480	COG1522	sequence-specific DNA binding
HU143_22485	COG0716	FMN binding
HU143_22500	COG3312	ion transport
HU143_22560	COG4533	DNA binding
HU143_22565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HU143_22570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HU143_22570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HU143_22570	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HU143_22575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HU143_22580	COG0573	inorganic phosphate transmembrane transporter activity
HU143_22585	COG0581	inorganic phosphate transmembrane transporter activity
HU143_22595	COG0704	Plays a role in the regulation of phosphate uptake
HU143_22600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HU143_22605	COG2252	PERMEase
HU143_22610	COG0431	NADPH-dependent FMN reductase
HU143_22615	COG2091	lysine biosynthetic process via aminoadipic acid
HU143_22740	COG2890	protein-(glutamine-N5) methyltransferase activity
HU143_23070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HU143_23090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HU143_23090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HU143_23175	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HU143_23205	COG0739	heme binding
HU143_23215	COG2132	Multicopper oxidase
HU143_23220	COG3667	copper resistance
HU143_23225	COG2372	response to copper ion
HU143_23230	COG1276	copper resistance
HU143_23235	COG0745	RESPONSE REGULATOR receiver
HU143_23240	COG2205	protein histidine kinase activity
HU143_23325	COG0697	spore germination
HU143_23370	COG3550	peptidyl-serine autophosphorylation
HU143_23450	COG1358	cellular component organization or biogenesis
HU143_23480	COG4245	von Willebrand factor, type A
HU143_23485	COG4245	von Willebrand factor, type A
HU143_23630	COG0210	DNA helicase
HU143_23725	COG1192	Involved in chromosome partitioning
HU143_23770	COG3039	Transposase
HU143_23950	COG0675	Transposase, IS605 OrfB family
HU143_23985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HU143_23990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HU143_24040	COG0741	lytic transglycosylase activity
HU143_24065	COG3133	Outer membrane lipoprotein
HU143_24170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HU143_24200	COG0305	Participates in initiation and elongation during chromosome replication
HU143_24345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair