locus-tag class description AM470_00005 ENOG4105MA0 exported protein AM470_00010 ENOG4108ZHD aig2 family AM470_00015 ENOG4105F0N pyrophosphate phospho-hydrolase AM470_00020 ENOG4105C8Q Methyl-accepting chemotaxis AM470_00025 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 AM470_00030 ENOG4105DFU Cell wall formation (By similarity) AM470_00045 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AM470_00050 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AM470_00055 ENOG4105HVQ Regulatory factor of maltose metabolism AM470_00065 ENOG4105EAH synthase AM470_00070 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AM470_00075 ENOG4105K46 50S ribosomal protein l27 AM470_00080 ENOG4105QYV Membrane AM470_00085 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AM470_00100 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AM470_00105 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AM470_00110 ENOG4105HBR Rna-binding protein AM470_00115 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AM470_00120 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AM470_00125 ENOG4105EEI dihydropteroate synthase AM470_00130 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AM470_00150 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AM470_00155 ENOG4105CHV Transcription elongation factor NusA AM470_00160 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AM470_00165 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AM470_00170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AM470_00175 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AM470_00185 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AM470_00200 ENOG4105C1J atp-dependent rna helicase AM470_00205 ENOG41066VF YeeE YedE family protein AM470_00210 ENOG4105KSU Redox protein AM470_00215 ENOG4105DEN Luciferase family AM470_00240 ENOG4106RZ4 Peptidase U32 AM470_00245 ENOG4105CFP Peptidase U32 AM470_00250 ENOG4105XPQ lipid carrier protein AM470_00255 ENOG4108YYD acetyltransferase AM470_00260 ENOG41082IR Excinuclease ABC C subunit domain protein AM470_00265 ENOG4105D5Q Arginine ornithine antiporter AM470_00270 ENOG4105CXN decarboxylase AM470_00280 ENOG4108ZPB UPF0306 protein AM470_00285 ENOG4105K4T epimerase AM470_00290 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein AM470_00300 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AM470_00305 ENOG4105FD8 phosphonate metabolism protein PhnM AM470_00310 ENOG4105HRV phosphonate c-p lyase system protein phnl AM470_00315 ENOG4105ENV phosphonate C-P lyase system protein PhnK AM470_00320 ENOG4105FT8 Phosphonate metabolism AM470_00325 ENOG4105EKV Phosphonate metabolism protein AM470_00330 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH AM470_00335 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG AM470_00340 ENOG4107RJJ Transcriptional regulator AM470_00345 ENOG4107S21 permease AM470_00365 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AM470_00375 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AM470_00380 ENOG410642W LysR family Transcriptional regulator AM470_00385 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AM470_00390 ENOG4105CG3 alpha amylase, catalytic region AM470_00395 ENOG4105C5Y PTS System AM470_00400 ENOG4105D4X repressor AM470_00405 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AM470_00410 ENOG4105E2D ec 3.2.1.52 AM470_00420 ENOG4105KME endoribonuclease L-psp AM470_00425 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AM470_00430 ENOG4105CXT aspartate transcarbamylase AM470_00440 ENOG4105DBV ornithine carbamoyltransferase AM470_00445 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) AM470_00450 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AM470_00455 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AM470_00460 ENOG4108MJ3 acetyltransferase AM470_00470 ENOG4105MYG DNA polymerase iii, chi subunit AM470_00475 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AM470_00480 ENOG4108M8S permease YjgP YjgQ family protein AM470_00485 ENOG4108K5H permease YjgP YjgQ family protein AM470_00500 ENOG4107YC3 synthase AM470_00510 ENOG4105EDR glucose galactose transporter AM470_00520 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AM470_00525 ENOG4105C6Z Gluconate AM470_00530 ENOG4105EXW epimerase dehydratase AM470_00535 ENOG4105MVE transcriptional regulator AM470_00550 ENOG4107QMH DNA methylase AM470_00555 ENOG4107J0C type IIi AM470_00605 ENOG4105CS2 ec 3.2.1.21 AM470_00625 ENOG4105CKI cobalamin synthesis protein AM470_00630 ENOG4105VCD cytoplasmic protein AM470_00635 ENOG4105D22 carbon starvation protein AM470_00640 ENOG4105DDW LysR family Transcriptional regulator AM470_00670 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AM470_00680 ENOG4105CFQ glutamine synthetase AM470_00720 ENOG4106NZI LysR family Transcriptional regulator AM470_00725 ENOG4105D6N CoA-transferase, subunit a AM470_00735 ENOG4105CHU acetyl-coa acetyltransferase AM470_00740 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) AM470_00745 ENOG4105CY2 Citrate transporter AM470_00750 ENOG4105DTD Dehydrogenase AM470_00760 ENOG4105R1U AraC Family Transcriptional Regulator AM470_00770 ENOG4105UEI Transcriptional Regulator AraC Family AM470_00775 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM470_00790 ENOG4105M8F Biopolymer transport protein exbD tolR AM470_00825 ENOG4105C26 Dehydrogenase AM470_00830 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AM470_00835 ENOG4105EVZ LysR family transcriptional regulator AM470_00840 ENOG4105C0A alcohol dehydrogenase AM470_00845 ENOG4108UDW Transcriptional regulator, luxr family AM470_00855 ENOG4105CJP fad dependent oxidoreductase AM470_00865 ENOG4105E5G Alpha beta hydrolase fold AM470_00870 ENOG4105DGU Histone deacetylase AM470_00880 ENOG4108UAJ Transcriptional regulator AM470_00885 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) AM470_00895 ENOG4105C85 amino acid AM470_00915 ENOG4107ZQV short-chain dehydrogenase reductase AM470_00920 ENOG4108V8F Transcriptional regulator, MarR family AM470_00935 ENOG4105D7V transposase AM470_00940 ENOG4105C26 Dehydrogenase AM470_00975 ENOG4105EFA 4-hydroxyphenylacetate AM470_00980 ENOG4107UWN reductase AM470_00985 ENOG4107R6D beta-lactam binding protein AmpH AM470_00990 ENOG4105C6F GntR Family Transcriptional Regulator AM470_00995 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AM470_01000 ENOG4105ERH Fumarylacetoacetate hydrolase AM470_01005 ENOG4105DIA mandelate racemase muconate lactonizing AM470_01020 ENOG4105QJH Domain of unknown function (DUF718) AM470_01025 ENOG4105EDR glucose galactose transporter AM470_01030 ENOG4105F27 Major Facilitator AM470_01045 ENOG4108IG5 Transcriptional regulator AM470_01050 ENOG4105BZU Histidine kinase AM470_01055 ENOG4105YBH Protein of unknown function (DUF1435) AM470_01080 ENOG4105CPC Aldo Keto reductase AM470_01085 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AM470_01090 ENOG4108WPU DNA polymerase III subunit psi AM470_01095 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AM470_01100 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AM470_01105 ENOG4105K3G Periplasmic Protein AM470_01115 ENOG4105VDW Csbd family AM470_01120 ENOG4108NRW Phospholipase, patatin family AM470_01125 ENOG4105EYA deoxyribonuclease AM470_01130 ENOG4105D9N nucleoside AM470_01135 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AM470_01145 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AM470_01150 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AM470_01155 ENOG4105EUP HipA domain protein AM470_01160 ENOG41062Z9 Membrane AM470_01165 ENOG4105EAC phosphoserine phosphatase AM470_01170 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AM470_01175 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AM470_01185 ENOG4105CIS alcohol dehydrogenase AM470_01195 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AM470_01210 ENOG4105C5H ABC transporter AM470_01215 ENOG41090EK ompa motb domain protein AM470_01220 ENOG4108KHX Diguanylate cyclase AM470_01225 ENOG4108WS1 AM470_01230 ENOG4107SC1 transglycosylase AM470_01235 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) AM470_01240 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AM470_01245 ENOG4105CVJ phosphoglycerate mutase AM470_01250 ENOG4105UEI Transcriptional Regulator AraC Family AM470_01255 ENOG4108RH0 Crea protein AM470_01260 ENOG41065U4 response regulator AM470_01290 ENOG4105D1Q UPF0246 protein AM470_01295 ENOG4105BZG amino acid carrier protein AM470_01300 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM470_01305 ENOG4108RIR Molybdenum cofactor biosynthesis protein AM470_01315 ENOG4106HK8 GPR1 FUN34 yaaH family protein AM470_01320 ENOG4105CFG Acts as a chaperone (By similarity) AM470_01325 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AM470_01330 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AM470_01335 ENOG41063Z6 transcriptional regulator, lysR family AM470_01340 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AM470_01345 ENOG4105DTN riboflavin biosynthesis protein ribF AM470_01350 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AM470_01355 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AM470_01360 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AM470_01365 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AM470_01370 ENOG4105JQN Transcriptional regulator AM470_01390 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AM470_01395 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AM470_01400 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AM470_01415 ENOG4108NIW Leucine export protein LeuE AM470_01420 ENOG4105DWK Membrane AM470_01430 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AM470_01440 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AM470_01445 ENOG4105NWN ApaG protein AM470_01450 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AM470_01455 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AM470_01460 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AM470_01465 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AM470_01475 ENOG4105D3G Pseudouridine synthase AM470_01480 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AM470_01485 ENOG4105CQ2 DNA polymerase AM470_01490 ENOG4108KF1 Membrane AM470_01495 ENOG4105M71 acetolactate synthase 1 regulatory subunit AM470_01500 ENOG4105C7K acetolactate synthase AM470_01515 ENOG4106SMU thiamine transporter membrane protein AM470_01520 ENOG4105DP9 ABC transporter AM470_01535 ENOG4105S8Q sugar efflux transporter AM470_01540 ENOG4107QPK )-transporter AM470_01545 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AM470_01550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AM470_01555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AM470_01560 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AM470_01565 ENOG41064T2 transcriptional regulator, lysR family AM470_01570 ENOG4108IQE Amp-dependent synthetase and ligase AM470_01575 ENOG4105C7K acetolactate synthase AM470_01580 ENOG4108ZP8 Acetolactate synthase small subunit AM470_01585 ENOG4107B7Y DNA-binding transcriptional regulator FruR AM470_01590 ENOG4108RNS Exports L-alanine (By similarity) AM470_01595 ENOG4108V6E Cell division protein mraZ AM470_01600 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AM470_01605 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AM470_01610 ENOG4105CJN penicillin-binding protein AM470_01615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AM470_01620 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AM470_01625 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AM470_01635 ENOG4105CNI cell division protein FtsW AM470_01640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AM470_01645 ENOG4105DFU Cell wall formation (By similarity) AM470_01655 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AM470_01660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AM470_01665 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AM470_01680 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) AM470_01685 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AM470_01690 ENOG4105M6F mutator MutT protein AM470_01695 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AM470_01700 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AM470_01705 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AM470_01710 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AM470_01715 ENOG4105D7Q type ii secretion system AM470_01720 ENOG4107QHF type ii secretion system protein e AM470_01725 ENOG4108ZUW Major pilin subunit AM470_01730 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AM470_01735 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM470_01740 ENOG4106A72 regulatory protein AmpE AM470_01745 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AM470_01755 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AM470_01765 ENOG4105EN6 Membrane AM470_01775 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AM470_01780 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AM470_01785 ENOG4105C0H protease AM470_01790 ENOG4105BZU Histidine kinase AM470_01795 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AM470_01800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AM470_01805 ENOG4105DXN mazG family AM470_01810 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AM470_01835 ENOG4105C85 amino acid AM470_01840 ENOG4105C84 Histidine ammonia-lyase AM470_01845 ENOG4105CGP Urocanate hydratase AM470_01850 ENOG4105D2S major facilitator superfamily AM470_01855 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AM470_01860 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AM470_01865 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AM470_01870 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AM470_01875 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AM470_01880 ENOG4108MXK alkaline phosphatase isozyme conversion AM470_01885 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AM470_01890 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AM470_01895 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AM470_01900 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) AM470_01905 ENOG4105N0Z inner membrane protein ygbE AM470_01915 ENOG4105DRP amino acid AbC transporter AM470_01920 ENOG4106PMH Extracellular solute-binding protein family 3 AM470_01925 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AM470_01930 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AM470_01935 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AM470_01940 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AM470_01945 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AM470_01950 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AM470_01955 ENOG4108K5P (LipO)protein AM470_01960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM470_01965 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AM470_01980 ENOG4105CPC Aldo Keto reductase AM470_01985 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AM470_01990 ENOG4105EQ2 LysR family Transcriptional regulator AM470_01995 ENOG4105VZJ PTS System AM470_02000 ENOG4105CK1 PTS System AM470_02005 ENOG4105CS2 ec 3.2.1.21 AM470_02010 ENOG4105EZV Transcriptional regulator AM470_02035 ENOG4105Y3E Modulates RecA activity (By similarity) AM470_02040 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AM470_02045 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AM470_02070 ENOG4107VXZ Hydrolase AM470_02075 ENOG4105W39 Membrane AM470_02080 ENOG4105D9M gamma-glutamylcysteine synthetase AM470_02090 ENOG4108JU6 CBS domain protein AM470_02095 ENOG4106KVJ cytochrome C assembly protein AM470_02100 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AM470_02105 ENOG4105K5M 30s ribosomal protein S16 AM470_02110 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AM470_02120 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AM470_02125 ENOG4105ZTC transcriptional activator, Ogr delta AM470_02140 ENOG4108NE3 Salt-induced outer membrane protein AM470_02145 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM470_02150 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AM470_02155 ENOG4105CQC Prephenate dehydratase AM470_02165 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AM470_02170 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AM470_02180 ENOG4105C34 Pseudouridine synthase AM470_02185 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AM470_02190 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM470_02220 ENOG4105CV8 reductase AM470_02225 ENOG4105HEI LysR family (Transcriptional regulator AM470_02230 ENOG4107NA1 Endonuclease Exonuclease phosphatase AM470_02235 ENOG4105E9H Lytic Murein transglycosylase AM470_02240 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AM470_02245 ENOG4105D1A Methyltransferase AM470_02250 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AM470_02255 ENOG4107RZZ dna polymerase iii epsilon subunit AM470_02280 ENOG4105C5R Aminotransferase AM470_02295 ENOG4105CHM Aminotransferase AM470_02300 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AM470_02305 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) AM470_02310 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AM470_02315 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AM470_02320 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AM470_02330 ENOG4107QPN acyl-Coa dehydrogenase AM470_02335 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AM470_02340 ENOG4105E7A Glutamine amidotransferase AM470_02345 ENOG4105F7V ErfK ybiS ycfS ynhG family protein AM470_02350 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM470_02355 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM470_02360 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM470_02365 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM470_02370 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM470_02375 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) AM470_02380 ENOG4105CJ2 (LipO)protein AM470_02410 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM470_02415 ENOG4105CIN aminoacyl-histidine dipeptidase AM470_02420 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AM470_02425 ENOG4105V1F Fermentation respiration switch protein AM470_02430 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AM470_02450 ENOG4105DFP Integrase AM470_02530 ENOG4106PG1 outer membrane usher protein AM470_02535 ENOG4108FZ9 Chaperone AM470_02580 ENOG4107RTG Major Facilitator superfamily AM470_02585 ENOG4105ENX hydrolase AM470_02590 ENOG4105EQ2 LysR family Transcriptional regulator AM470_02595 ENOG4105YB8 TM2 domain containing protein AM470_02625 ENOG4105CPW cytochrome b561 AM470_02630 ENOG4105DEF Extracellular solute-binding protein, family 5 AM470_02635 ENOG4105KVH Transcriptional regulator AM470_02640 ENOG4108X0B nad(p)h dehydrogenase (quinone) AM470_02655 ENOG4108Z33 Thiol disulfide Interchange Protein AM470_02660 ENOG4108WFR AraC Family Transcriptional Regulator AM470_02665 ENOG4105C26 Dehydrogenase AM470_02675 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM470_02690 ENOG4107QS8 (LipO)protein AM470_02695 ENOG4107RA9 decarboxylase AM470_02705 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) AM470_02710 ENOG4105RI1 glycoprotein receptor AM470_02725 ENOG4105E98 transcriptional regulator DeoR family AM470_02730 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AM470_02735 ENOG4105JQN Transcriptional regulator AM470_02740 ENOG4105EUB pirin domain protein AM470_02745 ENOG4105CHJ isochorismatase hydrolase AM470_02760 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AM470_02770 ENOG41068WN AM470_02775 ENOG4105G4C Periplasmic ligand-binding sensor protein AM470_02785 ENOG4105F2W methyltransferase AM470_02790 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM470_02825 ENOG4105XYF acetyltransferase AM470_02830 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AM470_02845 ENOG4105SS3 AM470_02850 ENOG4108SF5 RNA Polymerase AM470_02900 ENOG4105HBA AroM protein AM470_02905 ENOG4105NBK UPF0345 protein AM470_02910 ENOG4105DH7 May be involved in recombination (By similarity) AM470_02915 ENOG4105DKQ ROK family AM470_02935 ENOG4105EYH Exonuclease AM470_02940 ENOG4107RH8 nuclease SbcCD subunit D AM470_02945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM470_02950 ENOG4105BZU Histidine kinase AM470_02960 ENOG4105CWM branched-chain amino acid transport system II carrier protein AM470_02965 ENOG4105C85 amino acid AM470_02970 ENOG41084S7 Plasmid maintenance system antidote protein AM470_02985 ENOG4105CUY Mechanosensitive ion channel AM470_02990 ENOG4107R28 alpha amylase, catalytic region AM470_03000 ENOG4105D3R alkyl hydroperoxide reductase AM470_03005 ENOG4108ZYK Acyl carrier protein phosphodiesterase AM470_03010 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AM470_03015 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AM470_03020 ENOG4105VIE preprotein translocase, subunit YajC AM470_03030 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AM470_03035 ENOG4108KIC (LipO)protein AM470_03040 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AM470_03045 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AM470_03050 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AM470_03055 ENOG4107YIM Involved in the transcription termination process (By similarity) AM470_03060 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AM470_03065 ENOG4108ZAI phosphatidylglycerophosphatase a AM470_03070 ENOG4105CPC Aldo Keto reductase AM470_03075 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AM470_03080 ENOG4105CTB Polyprenyl synthetase AM470_03085 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AM470_03090 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AM470_03095 ENOG4105CKT filamentous hemagglutinin AM470_03100 ENOG4105D5K Hemolysin activator protein AM470_03105 ENOG4107S0N DJ-1 family AM470_03110 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AM470_03115 ENOG4108VPT UPF0234 protein AM470_03120 ENOG4107RDB Major Facilitator AM470_03125 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AM470_03130 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AM470_03135 ENOG4105CCU oxidase (Subunit III) AM470_03140 ENOG4105BZ9 Cytochrome C oxidase, subunit I AM470_03145 ENOG4105E2S oxidase) subunit II AM470_03150 ENOG4105EYM Major Facilitator superfamily AM470_03155 ENOG4105IEY (LipO)protein AM470_03160 ENOG4105M85 Bola protein AM470_03165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AM470_03175 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AM470_03180 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AM470_03190 ENOG4105EIN peptidylprolyl cis-trans isomerase AM470_03195 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AM470_03200 ENOG4108TGP Thioesterase superfamily protein AM470_03205 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AM470_03210 ENOG4108NFA extracellular solute-binding protein AM470_03215 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) AM470_03225 ENOG4108XM1 transcriptional regulator AsnC family AM470_03230 ENOG4105BZ1 (ABC) transporter AM470_03235 ENOG4105BZ1 (ABC) transporter AM470_03240 ENOG4108YZA Nitrogen regulatory protein pii AM470_03245 ENOG4105BZU Histidine kinase AM470_03250 ENOG4105C29 acyl-CoA thioesterase AM470_03255 ENOG4108MNP Glycoprotein polysaccharide metabolism AM470_03260 ENOG41080UX Methyltransferase AM470_03295 ENOG4107QHF type ii secretion system protein e AM470_03300 ENOG4105D7Q type ii secretion system AM470_03350 ENOG4108M1A Chitin-binding protein AM470_03360 ENOG4105KF5 hemolysin expression-modulating protein AM470_03365 ENOG4108UKR Biofilm formation regulator YbaJ AM470_03375 ENOG4105DIK (ABC) transporter AM470_03380 ENOG4105CC5 ABC transporter AM470_03385 ENOG4105DSE periplasmic solute binding protein AM470_03390 ENOG4105YK5 50S ribosomal protein L36 AM470_03395 ENOG4105NRA 50s ribosomal protein l31 type b AM470_03400 ENOG4105BZS acriflavin resistance protein AM470_03405 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM470_03410 ENOG4108IG5 Transcriptional regulator AM470_03415 ENOG41090EX DsrE family AM470_03420 ENOG4106428 Protein of unknown function (DUF2496) AM470_03430 ENOG4105WD1 Membrane AM470_03435 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AM470_03440 ENOG4107QMP dna polymerase iii subunits gamma and tau AM470_03445 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AM470_03450 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AM470_03455 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AM470_03460 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AM470_03465 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AM470_03470 ENOG4107QQ0 gntp family AM470_03475 ENOG4105BZW Glycerate kinase AM470_03480 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AM470_03485 ENOG4107RE1 Inosine-guanosine kinase AM470_03490 ENOG4105CKD glutathione-regulated potassium-efflux system protein AM470_03495 ENOG4105EU0 Major facilitator Superfamily AM470_03500 ENOG4105CGH 5'-nucleotidase AM470_03510 ENOG4105C2C drug resistance transporter, Bcr CflA AM470_03520 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AM470_03545 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family AM470_03550 ENOG4108Z66 YbaK ebsC protein AM470_03555 ENOG4105MBR gumn family AM470_03560 ENOG4105C59 p-type ATPase AM470_03565 ENOG4108Z6Z Transcriptional regulator AM470_03570 ENOG4105G5H Membrane AM470_03575 ENOG4107QX8 SPFH domain, Band 7 family protein AM470_03590 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AM470_03595 ENOG4107QR8 Thioredoxin AM470_03600 ENOG4105E1F short-chain dehydrogenase reductase AM470_03605 ENOG4108UJV acyl-CoA thioesterase i AM470_03610 ENOG4108I0Y (ABC) transporter AM470_03615 ENOG4105CV6 ABC transporter, permease AM470_03620 ENOG4107QNK )-transporter AM470_03625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AM470_03630 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AM470_03635 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) AM470_03640 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AM470_03645 ENOG4105C8N cysteinyl-tRNA synthetase AM470_03650 ENOG4105WQ3 Rna-binding protein AM470_03655 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AM470_03685 ENOG4105BZU Histidine kinase AM470_03690 ENOG4105VEQ Cold shock protein AM470_03700 ENOG4105CDA abc transporter atp-binding protein AM470_03705 ENOG4105DRP amino acid AbC transporter AM470_03725 ENOG4105CH2 amidohydrolase AM470_03730 ENOG4105VEQ Cold shock protein AM470_03735 ENOG4105C2C drug resistance transporter, Bcr CflA AM470_03740 ENOG4105YA8 Transcriptional regulator AM470_03745 ENOG4107Z6W Protein CrcB homolog AM470_03750 ENOG4105BZU Histidine kinase AM470_03755 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) AM470_03760 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AM470_03765 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AM470_03770 ENOG4108Z43 UPF0250 protein AM470_03775 ENOG4105DZ1 carboxypeptidase AM470_03780 ENOG4105K6T rare lipoprotein A AM470_03785 ENOG4105CNI cell division protein FtsW AM470_03790 ENOG4105CJN penicillin-binding protein AM470_03795 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AM470_03800 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AM470_03805 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AM470_03810 ENOG4105DJF DNA polymerase III, delta' subunit AM470_03815 ENOG4108U2H Rare lipoprotein B AM470_03820 ENOG4105C8T Leucyl-tRNA synthetase AM470_03825 ENOG4107PAI alpha helical protein AM470_03835 ENOG4105DU0 nucleoside hydrolase AM470_03845 ENOG4105CDA abc transporter atp-binding protein AM470_03850 ENOG4105DRP amino acid AbC transporter AM470_03855 ENOG4105EAD ABC transporter AM470_03860 ENOG4107RP9 extracellular solute-binding protein, family 3 AM470_03865 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AM470_03870 ENOG4108JU5 Magnesium and cobalt efflux protein AM470_03875 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AM470_03880 ENOG4105C9A Phoh family AM470_03885 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AM470_03890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AM470_03895 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AM470_03930 ENOG4105CAQ asparagine synthetase AM470_03935 ENOG4105E03 chitinase AM470_03940 ENOG4105D4U had-superfamily hydrolase, subfamily iia AM470_03945 ENOG4105E2R ROK family AM470_03950 ENOG4105CE4 GlcNAc 6-P deacetylase AM470_03955 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AM470_03960 ENOG4105CI1 PTS System AM470_03965 ENOG4105CX6 glutaminyL-tRNA synthetase AM470_03970 ENOG4105J5J Outer membrane porin AM470_03975 ENOG4105GX6 (LipO)protein AM470_03985 ENOG41090R7 Ferric uptake AM470_03990 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AM470_03995 ENOG4105NNH LexA regulated protein AM470_04000 ENOG4105EV9 Alpha Beta Hydrolase AM470_04010 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AM470_04015 ENOG4105NTW Transcriptional regulator AM470_04025 ENOG4105EEX Two component transcriptional regulator (Winged helix family AM470_04030 ENOG4105C08 Histidine kinase AM470_04035 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AM470_04040 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AM470_04045 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AM470_04055 ENOG4105XIQ Protein of unknown function (DUF2517) AM470_04060 ENOG4107SEY Conserved Protein AM470_04065 ENOG4105CVP deoxyribo-dipyrimidine photolyase AM470_04070 ENOG4107RF4 Phosphodiesterase AM470_04075 ENOG4107QNR UPF0135 protein AM470_04080 ENOG4105P4J Allophanate hydrolase, subunit 1 AM470_04085 ENOG4107R7A Allophanate hydrolase subunit 2 AM470_04090 ENOG4105E7W lamb ycsf family protein AM470_04115 ENOG4105BZN citrate synthase AM470_04120 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AM470_04125 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AM470_04130 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AM470_04135 ENOG4105E33 succinate dehydrogenase AM470_04140 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AM470_04145 ENOG4105C7S Dehydrogenase AM470_04150 ENOG4105CMV Succinyl-CoA synthetase subunit beta AM470_04155 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AM470_04160 ENOG4105CGH 5'-nucleotidase AM470_04165 ENOG4105C4M (Ubiquinol oxidase) subunit I AM470_04170 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM470_04180 ENOG4105KJB cyd operon protein YbgE AM470_04185 ENOG4107YD3 Thioesterase AM470_04190 ENOG4105E02 MotA TolQ exbB proton channel AM470_04195 ENOG4105M8F Biopolymer transport protein exbD tolR AM470_04200 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AM470_04200 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AM470_04205 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AM470_04210 ENOG4105KCK Peptidoglycan-associated lipoprotein AM470_04215 ENOG4105UFD tol-pal system protein YbgF AM470_04255 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AM470_04260 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AM470_04265 ENOG4105PGM cation diffusion facilitator family transporter AM470_04270 ENOG4105BZU Histidine kinase AM470_04275 ENOG4108WQH regulatoR AM470_04280 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM470_04295 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AM470_04305 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AM470_04310 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AM470_04315 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AM470_04330 ENOG4105DKW ABC transporter AM470_04335 ENOG4105F4R Transcriptional regulator mode AM470_04340 ENOG4105E0K tonB-dependent siderophore receptor AM470_04350 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AM470_04355 ENOG4105EHG Permease protein AM470_04360 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AM470_04365 ENOG410680R Protein of unknown function (DUF2592) AM470_04370 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AM470_04375 ENOG4105E0C molybdate abc transporter AM470_04385 ENOG4108K4B hydrolase AM470_04390 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AM470_04395 ENOG4108V1U phospholipid-binding protein AM470_04400 ENOG4105PGM cation diffusion facilitator family transporter AM470_04445 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AM470_04450 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AM470_04455 ENOG4105CHW UPF0052 protein AM470_04460 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AM470_04465 ENOG4108RIR Molybdenum cofactor biosynthesis protein AM470_04470 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AM470_04475 ENOG4105M00 molybdopterin converting factor, subunit 1 AM470_04480 ENOG4108ZAF Molybdopterin AM470_04485 ENOG4105HFZ Membrane AM470_04490 ENOG4107QWP ABC-2 type transporter AM470_04495 ENOG4107QWP ABC-2 type transporter AM470_04500 ENOG4105CJ1 ABC, transporter AM470_04505 ENOG4105D0S secretion protein (HlyD AM470_04510 ENOG4107MVR Transcriptional regulator AM470_04515 ENOG4105C1J atp-dependent rna helicase AM470_04520 ENOG4108JQ1 Dehydrogenase AM470_04525 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AM470_04535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_04540 ENOG4107RCV ABC transporter, permease AM470_04545 ENOG4105C4Y ABC transporter AM470_04550 ENOG4105CXY transporter AM470_04555 ENOG4105BZU Histidine kinase AM470_04560 ENOG4108KX4 response regulator AM470_04565 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AM470_04570 ENOG4105CHR reductase AM470_04575 ENOG4105W8I Transcriptional regulator AM470_04585 ENOG4105C85 amino acid AM470_04595 ENOG4105C5Q Transcriptional regulator AM470_04600 ENOG4105KHU inner membrane protein YohD AM470_04610 ENOG4105ECQ AraC Family Transcriptional Regulator AM470_04615 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AM470_04620 ENOG41061WM D-Alanyl-D-Alanine AM470_04640 ENOG4105CKW Inner membrane protein yedI AM470_04650 ENOG4105D01 (LipO)protein AM470_04660 ENOG4108U7W acetyltransferase AM470_04670 ENOG41069YE inner membrane protein yohC AM470_04680 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AM470_04695 ENOG4105EHG Permease protein AM470_04700 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AM470_04705 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AM470_04710 ENOG4105CXG d-lactate dehydrogenase AM470_04715 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AM470_04725 ENOG4105CPF Cell wall formation (By similarity) AM470_04730 ENOG4105E89 ABC transporter AM470_04735 ENOG4105CHM Aminotransferase AM470_04745 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AM470_04765 ENOG4105S10 periplasmic binding protein AM470_04770 ENOG4105EHG Permease protein AM470_04775 ENOG4108W0P ABC transporter AM470_04780 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein AM470_04785 ENOG41082A2 Alpha beta hydrolase AM470_04790 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) AM470_04800 ENOG4107QJE Chromosome Partitioning Protein AM470_04805 ENOG4105N1F Hnh endonuclease AM470_04810 ENOG4105CC0 LysR family Transcriptional regulator AM470_04815 ENOG4107RTG Major Facilitator superfamily AM470_04820 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AM470_04825 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound AM470_04830 ENOG4108594 Permease of the drug metabolite transporter AM470_04855 ENOG4105E5K Alpha-amylase AM470_04860 ENOG4107Y60 (LipO)protein AM470_04870 ENOG4106B0W Curli production assembly transport component CsgG AM470_04875 ENOG4108MJ3 acetyltransferase AM470_04885 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AM470_04890 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AM470_04895 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AM470_04900 ENOG4108IND Tetr family transcriptional regulator AM470_04905 ENOG4105D01 (LipO)protein AM470_04910 ENOG4108UMI ABC transporter, permease AM470_04915 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AM470_04920 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AM470_04940 ENOG4106KE4 Dehydrogenase AM470_04955 ENOG4105EHI Phosphonate ABC transporter, periplasmic AM470_04970 ENOG4108W15 Protein of unknown function (DUF1456) AM470_04990 ENOG4105DRR Transcriptional regulator, GntR family AM470_05000 ENOG4105C32 Amino acid ABC transporter (Permease) AM470_05005 ENOG4105CNN ABC, transporter AM470_05010 ENOG4105C0Z ABC transporter AM470_05015 ENOG4108IV0 ABC, transporter AM470_05050 ENOG4107NQ8 LysR family Transcriptional regulator AM470_05055 ENOG4105KHC sulfurtransferase AM470_05060 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AM470_05065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM470_05075 ENOG4108TGY Glutathione S-transferase AM470_05095 ENOG4105CHJ isochorismatase hydrolase AM470_05100 ENOG4105EQ1 Transcriptional regulator AM470_05115 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AM470_05120 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component AM470_05125 ENOG4108IJ8 ABC transporter AM470_05130 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component AM470_05150 ENOG4105FDR Membrane AM470_05185 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AM470_05190 ENOG4105CD5 CoA-binding domain protein AM470_05200 ENOG4108N27 Glutathione S-transferase AM470_05205 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AM470_05210 ENOG4105MDS 4-oxalocrotonate tautomerase AM470_05215 ENOG4105DVT helicase AM470_05230 ENOG4108JU7 Transcriptional regulator AM470_05235 ENOG4105CR4 methylisocitrate lyase AM470_05240 ENOG4105BZN citrate synthase AM470_05245 ENOG4105DXD 2-methylcitrate dehydratase AM470_05250 ENOG410829K Lysine exporter protein (Lyse ygga) AM470_05270 ENOG4108MTB glycosyl transferase family AM470_05280 ENOG4107B2H carbonic anhydrase AM470_05285 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AM470_05290 ENOG4105EW6 flavin reductase domain protein, FMN-binding AM470_05295 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AM470_05300 ENOG4107SDU Methyl-accepting chemotaxis AM470_05305 ENOG4108RZE Tetr family transcriptional regulator AM470_05320 ENOG4105D8X mechanosensitive ion channel AM470_05325 ENOG4105CDA abc transporter atp-binding protein AM470_05330 ENOG4105E5Q amino acid AbC transporter AM470_05335 ENOG4107R0W ABC transporter AM470_05340 ENOG4105KSC Transcriptional regulator, TraR DksA family AM470_05355 ENOG4108R66 Conserved Protein AM470_05365 ENOG4108T1M outer membrane protein x AM470_05370 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AM470_05385 ENOG4105C6Z Gluconate AM470_05390 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AM470_05395 ENOG4105FB2 class II Aldolase AM470_05400 ENOG4105G63 Type III effector Hrp-dependent AM470_05405 ENOG4105ZXK Dehydrogenase AM470_05410 ENOG4105MVE transcriptional regulator AM470_05420 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AM470_05425 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) AM470_05460 ENOG4108NN8 Fimbrial protein AM470_05465 ENOG4108N3D putative enzyme AM470_05470 ENOG4106PYX Receptor AM470_05480 ENOG4105BZU Histidine kinase AM470_05485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM470_05490 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) AM470_05495 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AM470_05510 ENOG4105C94 Transporter AM470_05515 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AM470_05520 ENOG4105C26 Dehydrogenase AM470_05525 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AM470_05530 ENOG4105CBC glutamate synthase AM470_05540 ENOG4105CMB EAL domain-containing protein AM470_05550 ENOG4108VCD Chaperone AM470_05555 ENOG4105CW0 outer membrane usher protein AM470_05565 ENOG4105UEI Transcriptional Regulator AraC Family AM470_05570 ENOG4105DWT malate dehydrogenase (quinone) AM470_05580 ENOG4105CYM Glutathione S-transferase AM470_05585 ENOG4108ZHR arsR family transcriptional regulator AM470_05595 ENOG4105CHJ isochorismatase hydrolase AM470_05600 ENOG4105EQ2 LysR family Transcriptional regulator AM470_05615 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AM470_05620 ENOG4107B2H carbonic anhydrase AM470_05625 ENOG4105DND Transcriptional regulator AM470_05635 ENOG4105C5H ABC transporter AM470_05640 ENOG4105D06 uba thif-type nad fad binding protein AM470_05645 ENOG4105CVM Molybdenum cofactor synthesis domain protein AM470_05655 ENOG4105D44 asparaginase AM470_05660 ENOG4108JQ6 ABC transporter AM470_05665 ENOG4105DEF Extracellular solute-binding protein, family 5 AM470_05670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM470_05675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM470_05700 ENOG4105EGI Transcriptional regulator AM470_05705 ENOG4105CBP Major Facilitator AM470_05710 ENOG4105EUJ GTP cyclohydrolase i AM470_05715 ENOG4105DHF Membrane AM470_05720 ENOG41060NJ transcriptional regulator AM470_05735 ENOG4107SDZ Galactoside transport system permease protein mglC AM470_05740 ENOG4107GZ4 SanA protein AM470_05745 ENOG4107R1I NAD-dependent malic enzyme AM470_05750 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AM470_05755 ENOG41067MG lrgb family AM470_05760 ENOG4105VAW lrga family AM470_05765 ENOG4105E5W Transporter AM470_05775 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AM470_05780 ENOG4105D1F ATP-binding protein AM470_05785 ENOG4105MH5 phosphoesterase PA-phosphatase related protein AM470_05790 ENOG4105DBI uridine monophosphokinase AM470_05795 ENOG4105DHP deoxycytidine triphosphate deaminase AM470_05800 ENOG4108GAE asmA family AM470_05805 ENOG4105CEE C4-dicarboxylate transporter AM470_05810 ENOG4105EE5 Membrane protein terC AM470_05815 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM470_05820 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM470_05825 ENOG4105DAY polysaccharide export protein AM470_05830 ENOG4105KJF protein tyrosine phosphatase AM470_05835 ENOG4105D75 Capsular exopolysaccharide family AM470_05840 ENOG4105F0R Cytidylyltransferase AM470_05845 ENOG4105D2T synthase AM470_05850 ENOG4108MY6 biosynthesis protein AM470_05855 ENOG4105EQK -acetyltransferase AM470_05875 ENOG4108TJN glycosyl transferase group 1 AM470_05885 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AM470_05910 ENOG4108JJ6 Type I secretion system ATPase AM470_05915 ENOG4107QZV Type I secretion membrane fusion protein AM470_05920 ENOG4105DFG type I secretion outer membrane protein AM470_05935 ENOG4105CMR udp-glucose 4-epimerase AM470_05940 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AM470_05950 ENOG4105MFV ABC-2 type transporter AM470_05955 ENOG4105EY8 ABC transporter AM470_05985 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AM470_05990 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AM470_05995 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AM470_06000 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AM470_06005 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AM470_06015 ENOG4105CIH Imidazole acetol-phosphate transaminase AM470_06020 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AM470_06025 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AM470_06035 ENOG4108535 NAD dependent epimerase/dehydratase family AM470_06040 ENOG4105EVZ LysR family transcriptional regulator AM470_06045 ENOG4105CYW agmatinase AM470_06050 ENOG4107QN1 sodium solute AM470_06055 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AM470_06060 ENOG4105D7N magnesium and cobalt transport protein CorA AM470_06070 ENOG4105D8V Glucose sorbosone dehydrogenase AM470_06075 ENOG4108TGY Glutathione S-transferase AM470_06090 ENOG4105C28 cystathionine AM470_06100 ENOG4105DZ1 carboxypeptidase AM470_06125 ENOG4108RQP Major type 1 subunit fimbrin AM470_06130 ENOG4106PG1 outer membrane usher protein AM470_06135 ENOG4108FZ9 Chaperone AM470_06155 ENOG4108V1T peptidylprolyl cis-trans isomerase AM470_06160 ENOG41068CG regulatoR AM470_06165 ENOG4105EJQ L-serine dehydratase AM470_06170 ENOG4105C44 Serine transporter AM470_06175 ENOG4107FB0 transcriptional regulator DeoR family AM470_06180 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AM470_06190 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AM470_06205 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) AM470_06210 ENOG4105ETT transcriptional Regulator, LysR family AM470_06215 ENOG4107S2N Type III effector Hrp-dependent AM470_06220 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AM470_06245 ENOG4108KPJ rna polymerase sigma factor AM470_06250 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AM470_06270 ENOG4105MEH AM470_06305 ENOG4105KSC Transcriptional regulator, TraR DksA family AM470_06345 ENOG4105ED4 portal protein AM470_06425 ENOG4108X9F tail fiber protein AM470_06430 ENOG4105UZW Tail fiber assembly protein AM470_06475 ENOG4105ZTC transcriptional activator, Ogr delta AM470_06485 ENOG4105D0C transport protein AM470_06490 ENOG4105GWF inner membrane protein YbjM AM470_06495 ENOG41090BQ Glutaredoxin AM470_06500 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress AM470_06505 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AM470_06510 ENOG4108RMJ sensory transduction regulator AM470_06515 ENOG4107RUE extracellular solute-binding protein family 1 AM470_06520 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_06525 ENOG4105F38 ABC transporter, permease AM470_06530 ENOG4105D38 putrescine abc transporter AM470_06535 ENOG4105RBQ inner membrane protein ybjO AM470_06540 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) AM470_06545 ENOG4105K4U addiction module toxin, RelE StbE family AM470_06555 ENOG4106TNF Periplasmic binding protein AM470_06560 ENOG4105DMR ABC, transporter AM470_06565 ENOG4105GBT ABC transporter AM470_06570 ENOG4106PMH Extracellular solute-binding protein family 3 AM470_06575 ENOG4105E5Z arginine transporter ATP-binding subunit AM470_06580 ENOG41064MM (LipO)protein AM470_06585 ENOG4105K8R UPF0145 protein AM470_06590 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM470_06595 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AM470_06600 ENOG4105CGD Nad-dependent epimerase dehydratase AM470_06610 ENOG4105NYY transcriptional regulator, RpiR AM470_06615 ENOG4105CI1 PTS System AM470_06620 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) AM470_06625 ENOG4105C5W Aldolase AM470_06630 ENOG4105C7K acetolactate synthase AM470_06635 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM470_06640 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AM470_06645 ENOG4105DWU Membrane AM470_06650 ENOG4105CPB ATP-dependent endonuclease of the OLD family AM470_06655 ENOG4108MJ5 VirK protein AM470_06660 ENOG4105DJY efflux transporter, rnd family, mfp subunit AM470_06670 ENOG4105VEQ Cold shock protein AM470_06675 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AM470_06680 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM470_06685 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AM470_06690 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AM470_06695 ENOG4108JJ8 (ABC) transporter AM470_06700 ENOG4108JJ9 ABC, transporter AM470_06705 ENOG4105C3M thioredoxin reductase AM470_06710 ENOG4105EW9 transcriptional regulator AsnC family AM470_06715 ENOG4105CNU cell division protein FtsK AM470_06720 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AM470_06725 ENOG4105D1H recombination factor protein RarA AM470_06730 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AM470_06740 ENOG4108ISG Major Facilitator AM470_06745 ENOG4105F1A Pyruvate formate-lyase AM470_06750 ENOG4105C6N Formate acetyltransferase AM470_06755 ENOG4105TMB Formate nitrite transporter AM470_06760 ENOG4105DDY UPF0142 protein ycaO AM470_06775 ENOG4105HDK L-asparaginase AM470_06780 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AM470_06785 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AM470_06790 ENOG4105CAT Cytidine monophosphate kinase AM470_06795 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AM470_06805 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AM470_06810 ENOG4105BZ1 (ABC) transporter AM470_06815 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AM470_06820 ENOG4105E32 cytoplasmic protein AM470_06825 ENOG4105VEQ Cold shock protein AM470_06830 ENOG4105VEQ Cold shock protein AM470_06835 ENOG4105T0Z Conserved Protein AM470_06840 ENOG4105W49 UPF0434 protein AM470_06845 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AM470_06850 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups AM470_06855 ENOG4107S90 membrAne AM470_06860 ENOG4106371 Methyltransferase AM470_06865 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) AM470_06870 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AM470_06875 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AM470_06880 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AM470_06885 ENOG4105EAQ (twin-arginine translocation) pathway signal AM470_06890 ENOG4105C5X domain protein AM470_06895 ENOG4105CGF Aromatic amino acid aminotransferase AM470_06910 ENOG4107RH7 Nicotinate phosphoribosyltransferase AM470_06915 ENOG4105BZU Histidine kinase AM470_06920 ENOG4105CD8 aminopeptidase N AM470_06930 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AM470_06935 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AM470_06940 ENOG4105GVF (ABC) transporter AM470_06945 ENOG4108UZX fmn reductase AM470_06950 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AM470_06955 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AM470_06960 ENOG4105QVC MOSC domain-containing protein AM470_06965 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AM470_06970 ENOG4105C5H ABC transporter AM470_06975 ENOG4105F1S paraquat-inducible protein a AM470_06980 ENOG4105DY2 Paraquat-inducible protein b AM470_06985 ENOG4108Q2G (LipO)protein AM470_06990 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) AM470_06995 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM470_07005 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AM470_07010 ENOG4105DAN ATP-dependent protease AM470_07030 ENOG4108RZ1 DNA transformation protein AM470_07035 ENOG4105EM2 membrane AM470_07040 ENOG410901E Membrane AM470_07045 ENOG41088T4 Helicase IV AM470_07050 ENOG4108Z5K methylglyoxal synthase AM470_07060 ENOG4105K4P CoA-binding domain protein AM470_07065 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) AM470_07070 ENOG4105DR4 Methyltransferase AM470_07085 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AM470_07090 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AM470_07095 ENOG4108MN8 Membrane AM470_07120 ENOG41068CG regulatoR AM470_07130 ENOG4108MQF Chaperone AM470_07135 ENOG4105CW0 outer membrane usher protein AM470_07150 ENOG4105EQ2 LysR family Transcriptional regulator AM470_07155 ENOG4108Z4X TRANSCRIPTIONal AM470_07165 ENOG4105ENT Efflux transporter rnd family, mfp subunit AM470_07170 ENOG4105BZS acriflavin resistance protein AM470_07180 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AM470_07190 ENOG4105CS1 NAD(P)H quinone oxidoreductase AM470_07205 ENOG4105C85 amino acid AM470_07215 ENOG4108KF1 Membrane AM470_07220 ENOG4105CSP Major Facilitator Superfamily AM470_07240 ENOG4105E39 Enoyl-CoA hydratase AM470_07245 ENOG4105F27 Major Facilitator AM470_07250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM470_07255 ENOG4105CHU acetyl-coa acetyltransferase AM470_07260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM470_07270 ENOG4108U51 Universal stress protein AM470_07280 ENOG4105DG4 malate L-lactate dehydrogenase AM470_07285 ENOG4107QTZ amino acid AM470_07290 ENOG4105CZJ Aldehyde dehydrogenase AM470_07295 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AM470_07305 ENOG4105CTU Proline racemase AM470_07310 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AM470_07335 ENOG4105RA2 Membrane AM470_07340 ENOG4105XVG cytoplasmic protein AM470_07345 ENOG4105WH1 Two component transcriptional regulator luxr family AM470_07350 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AM470_07375 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AM470_07405 ENOG4105CSH Transporter AM470_07410 ENOG4105ETP RND efflux system, outer membrane lipoprotein AM470_07420 ENOG4105DJY efflux transporter, rnd family, mfp subunit AM470_07425 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) AM470_07440 ENOG4105GSJ Inner membrane protein ylaC AM470_07460 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) AM470_07465 ENOG4105DJ9 glucan biosynthesis protein AM470_07470 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) AM470_07475 ENOG4105NAC (LipO)protein AM470_07485 ENOG4108W47 Acidic protein msyB AM470_07490 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AM470_07500 ENOG41080HT Transcriptional regulator, arsr family AM470_07515 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AM470_07520 ENOG4105DUX Transporter AM470_07525 ENOG4105C6X Major Facilitator AM470_07535 ENOG4105D1S lipid A biosynthesis AM470_07545 ENOG4105C72 UPF0176 protein AM470_07550 ENOG4108YYC ycei family AM470_07555 ENOG4105DS1 cytochrome b561 AM470_07560 ENOG4105DSF transport protein AM470_07585 ENOG4105PVA Biofilm formation regulatory protein BssS AM470_07600 ENOG4105EKE dihydroorotase AM470_07605 ENOG41067V3 Antibiotic biosynthesis monooxygenase AM470_07610 ENOG4107QQB Ribonuclease E AM470_07620 ENOG4105EI2 Pseudouridine synthase AM470_07630 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AM470_07635 ENOG4105VGS 50s ribosomal protein l32 AM470_07640 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AM470_07645 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AM470_07650 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AM470_07655 ENOG4105CHR reductase AM470_07660 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AM470_07665 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM470_07670 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AM470_07675 ENOG4105HHA aminodeoxychorismate lyase AM470_07680 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AM470_07685 ENOG4107QRG dna polymerase iii AM470_07690 ENOG4105F8V Hydrolase, tatD family AM470_07695 ENOG4105CI1 PTS System AM470_07815 ENOG4105ED4 portal protein AM470_07855 ENOG4105DFE Dna adenine methylase AM470_07900 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM470_07915 ENOG4105KST dependent repressor AM470_07920 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AM470_07925 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AM470_07930 ENOG4105KVH Transcriptional regulator AM470_07940 ENOG4105K59 histidine triad (HIT) protein AM470_07945 ENOG41090DQ Lipoprotein AM470_07950 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) AM470_07965 ENOG4105D0Y UPF0227 protein AM470_07970 ENOG4105CEP NADH dehydrogenase AM470_07975 ENOG4107MBR 17 kDa surface antigen AM470_07990 ENOG4105ENT Efflux transporter rnd family, mfp subunit AM470_07995 ENOG4105UEI Transcriptional Regulator AraC Family AM470_08020 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AM470_08025 ENOG4107SSZ Phosphatase AM470_08030 ENOG4107XHZ cytoplasmic chaperone TorD family protein AM470_08035 ENOG4108Q2J Inner membrane protein YebE AM470_08040 ENOG4105CUG Oligopeptidase b AM470_08045 ENOG4105UMD exodeoxyribonuclease X AM470_08050 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AM470_08060 ENOG4105MPK DNA polymerase III subunit theta AM470_08065 ENOG41090A1 ferritin AM470_08070 ENOG4105FXM Copper resistance protein AM470_08075 ENOG4108PNC copper resistance AM470_08080 ENOG4105NKT exported protein AM470_08100 ENOG4105RKW reductase (By AM470_08120 ENOG4108MRH transcriptional regulatory protein AM470_08125 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM470_08140 ENOG4105C2J ABC transporter AM470_08145 ENOG4105CNN ABC, transporter AM470_08160 ENOG4105D5U fad dependent oxidoreductase AM470_08180 ENOG4105D01 (LipO)protein AM470_08195 ENOG4107WCA isomerase AM470_08200 ENOG4107W6W Conserved Protein AM470_08205 ENOG4105CQ4 Transcriptional regulator AM470_08210 ENOG4105CNT hydrolase family 2 AM470_08215 ENOG4105FK9 beta-D-galactosidase beta subunit AM470_08220 ENOG4105E5D amino acid AM470_08225 ENOG41082SX arsR family transcriptional regulator AM470_08235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AM470_08255 ENOG4105CW0 outer membrane usher protein AM470_08260 ENOG4108MQF Chaperone AM470_08275 ENOG4105C3G gtp-binding protein AM470_08280 ENOG4105CHH sulfate transporter AM470_08285 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AM470_08290 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria AM470_08295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AM470_08300 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AM470_08305 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AM470_08310 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AM470_08315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AM470_08320 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AM470_08325 ENOG4108YY7 Invasion gene expression up-regulator SirB AM470_08330 ENOG41063JG Transcriptional regulator AM470_08335 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AM470_08340 ENOG4105CHH sulfate transporter AM470_08345 ENOG41090KN UPF0303 protein AM470_08350 ENOG4108JA2 transcriptioN-repair coupling factor AM470_08360 ENOG4105D60 lipoprotein releasing system transmembrane protein AM470_08370 ENOG4105D60 lipoprotein releasing system transmembrane protein AM470_08380 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AM470_08385 ENOG4107RUE extracellular solute-binding protein family 1 AM470_08395 ENOG4105F8D glycoside hydrolase family 4 AM470_08400 ENOG4105CI1 PTS System AM470_08405 ENOG4105D38 putrescine abc transporter AM470_08410 ENOG4105F38 ABC transporter, permease AM470_08420 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AM470_08445 ENOG4105DG4 malate L-lactate dehydrogenase AM470_08450 ENOG4105EZE Cupin 4 family protein AM470_08460 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM470_08465 ENOG4108KD5 ADP-ribosylation crystallin J1 AM470_08470 ENOG4105FDP GntR family transcriptional regulator AM470_08485 ENOG4105D9U N-acetyltransferase AM470_08490 ENOG4107QTF adenylosuccinate lyase AM470_08495 ENOG41075W9 High frequency lysogenization protein HflD homolog AM470_08505 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AM470_08520 ENOG4108R99 pseudouridine synthase AM470_08525 ENOG4108HMX isocitrate dehydrogenase (NADP) AM470_08530 ENOG4108RW8 Universal stress protein F AM470_08535 ENOG4105M5B (LipO)protein AM470_08540 ENOG4105M5B (LipO)protein AM470_08545 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AM470_08605 ENOG4105VEQ Cold shock protein AM470_08615 ENOG4105CHJ isochorismatase hydrolase AM470_08620 ENOG4108M6U Universal stress protein A AM470_08625 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AM470_08630 ENOG4105CJP fad dependent oxidoreductase AM470_08635 ENOG4105C26 Dehydrogenase AM470_08640 ENOG4107VRI Transcriptional regulator AM470_08645 ENOG4108Z86 Glutamine amidotransferase AM470_08650 ENOG4105CFQ glutamine synthetase AM470_08660 ENOG4105CUB amino acid AM470_08675 ENOG4105DRB nucleoside-specific channel-forming protein AM470_08690 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) AM470_08705 ENOG4105CI2 imidazolone-5-propionate hydrolase AM470_08710 ENOG4105CZE histidine utilization repressor AM470_08715 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AM470_08720 ENOG41090B9 response to stress AM470_08725 ENOG4106NDP Transcriptional regulator AM470_08730 ENOG4108HKT sucrose-6-phosphate hydrolase AM470_08735 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM470_08740 ENOG4105CSH Transporter AM470_08745 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AM470_08775 ENOG4105WT8 Protein of unknown function (DUF1480) AM470_08815 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AM470_08820 ENOG4105DY2 Paraquat-inducible protein b AM470_08825 ENOG4105H2K paraquat-inducible protein a AM470_08830 ENOG4108ZGC gaf domain protein AM470_08835 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AM470_08840 ENOG4105CN1 protease AM470_08845 ENOG4105D0M Protease HtpX homolog AM470_08855 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_08860 ENOG4105J4Q Transcriptional regulator AM470_08865 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AM470_08870 ENOG4108MP3 ABC transporter, permease AM470_08875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_08880 ENOG4105CY5 solute-binding protein AM470_08885 ENOG4106S9K Transcriptional regulator AM470_08900 ENOG4108ETY sodium dicarboxylate symporter AM470_08905 ENOG4107K5X Membrane-bound metal-dependent hydrolase AM470_08910 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AM470_08920 ENOG4107PN8 YfeABCD locus regulator AM470_08925 ENOG4105FGM Fructosamine kinase AM470_08930 ENOG4105CC5 ABC transporter AM470_08935 ENOG4105CC5 ABC transporter AM470_08940 ENOG4105DIK (ABC) transporter AM470_08945 ENOG4105DSE periplasmic solute binding protein AM470_08950 ENOG4105P10 Uncharacterized protein ydiZ AM470_08955 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AM470_08975 ENOG4105C44 Serine transporter AM470_09060 ENOG4108XTP Transcriptional regulator AM470_09080 ENOG4105YQ0 AM470_09090 ENOG4108MXB Protein of unknown function (DUF968) AM470_09095 ENOG4105QBX endodeoxyribonuclease RusA AM470_09100 ENOG4105HRS Antitermination protein AM470_09140 ENOG41061CV Terminase small subunit AM470_09145 ENOG4108N0N Phage Terminase Large Subunit AM470_09285 ENOG4105KT5 UmuD protein AM470_09290 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM470_09295 ENOG4108RAV Conserved protein AM470_09300 ENOG4105C22 threonyL-tRNA synthetase AM470_09310 ENOG41082NX 50s ribosomal protein l35 AM470_09315 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AM470_09320 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AM470_09340 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) AM470_09345 ENOG4108V06 Glutathione peroxidase AM470_09350 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AM470_09355 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AM470_09360 ENOG4105CKK Glycosyl transferase, family 2 AM470_09365 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM470_09370 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM470_09375 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM470_09380 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AM470_09385 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AM470_09390 ENOG4108QBX (LipO)protein AM470_09395 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AM470_09415 ENOG4105EHG Permease protein AM470_09420 ENOG4107R4I Periplasmic binding protein AM470_09425 ENOG4106QJH hemin transport protein AM470_09430 ENOG4107ENK receptor AM470_09435 ENOG4107F3C Hemin uptake protein AM470_09440 ENOG4108V06 Glutathione peroxidase AM470_09445 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM470_09450 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AM470_09460 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AM470_09470 ENOG4105IPI Membrane AM470_09475 ENOG4105CQB FAD linked oxidase domain protein AM470_09480 ENOG4105KA0 thioesterase Superfamily protein AM470_09490 ENOG4108Z4V iron-sulfur cluster assembly AM470_09495 ENOG4105DIW FeS assembly protein SUFB AM470_09500 ENOG4105C3K feS assembly ATPase SufC AM470_09505 ENOG4105JRK feS assembly protein SufD AM470_09510 ENOG4105C9B Cysteine desulfurase AM470_09515 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AM470_09520 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM470_09530 ENOG4105CA9 Pyruvate kinase AM470_09555 ENOG4107QI1 Mate efflux family protein AM470_09560 ENOG4108R6K riboflavin synthase, subunit alpha AM470_09570 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AM470_09575 ENOG4105CZQ inner membrane transport protein YdhC AM470_09580 ENOG4105F52 Transcriptional regulator AM470_09585 ENOG4105ETE Transcriptional regulator (LacI family AM470_09595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM470_09600 ENOG4105K4H Nlp p60 protein AM470_09605 ENOG4105M2J Glutaredoxin AM470_09615 ENOG4108UYE Lactoylglutathione lyase AM470_09620 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM470_09625 ENOG4108WUH Transcriptional regulator, TetR family AM470_09630 ENOG4105DIJ Phosphoethanolamine transferase AM470_09640 ENOG4105EJC lysr family transcriptional regulator AM470_09645 ENOG4105XZD Fe-S protein AM470_09650 ENOG4107RGM aldo keto reductase AM470_09660 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM470_09665 ENOG4105DSW Fusaric acid resistance protein AM470_09670 ENOG4105Y49 secretion protein, HlyD family AM470_09680 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AM470_09685 ENOG4108XTF Outer Membrane Lipoprotein AM470_09690 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AM470_09700 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AM470_09705 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AM470_09720 ENOG4108K3A Glutathione S-transferase AM470_09730 ENOG4108ZR5 Conserved Protein AM470_09735 ENOG4105EST Metal Dependent Phosphohydrolase AM470_09755 ENOG4105KME endoribonuclease L-psp AM470_09770 ENOG4105DKK Benzoate AM470_09775 ENOG4108JCI Transcriptional regulator AM470_09785 ENOG4105DUX Transporter AM470_09790 ENOG4105CSM endonuclease III AM470_09800 ENOG4108UQQ Electron transport complex AM470_09810 ENOG4105UEI Transcriptional Regulator AraC Family AM470_09815 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AM470_09820 ENOG4108R3D Electron transport complex AM470_09825 ENOG4105DGN Electron transport complex AM470_09830 ENOG4105M9B inner membrane protein ydgK AM470_09835 ENOG4105D9R oxidoreductase AM470_09840 ENOG4105DHU Bile acid AM470_09850 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AM470_09855 ENOG4105E98 transcriptional regulator DeoR family AM470_09860 ENOG4107VIJ nudix hydrolase AM470_09870 ENOG4105C87 Aminotransferase class I and II AM470_09875 ENOG4105CI1 PTS System AM470_09880 ENOG4107P2S Transcriptional regulator AM470_09885 ENOG4105ETT transcriptional Regulator, LysR family AM470_09895 ENOG410642W LysR family Transcriptional regulator AM470_09900 ENOG4107S1E Beta-lactamase AM470_09905 ENOG4106J39 exported protein AM470_09910 ENOG4105EIP mannose-6-phosphate isomerase AM470_09920 ENOG4105C9Q fumarate hydratase class II AM470_09925 ENOG4105D29 Helix-turn-helix type 11 domain protein AM470_09935 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) AM470_09940 ENOG4105D17 glycoside hydrolase, family 3 domain protein AM470_09945 ENOG4105F32 YngK protein AM470_09950 ENOG4105D94 Major Facilitator Superfamily AM470_09955 ENOG4106NZI LysR family Transcriptional regulator AM470_09960 ENOG4105DAG ROK family AM470_09965 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AM470_09975 ENOG4108Z4X TRANSCRIPTIONal AM470_09985 ENOG4108IJ8 ABC transporter AM470_09990 ENOG4105E90 ABC transporter AM470_09995 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AM470_10000 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component AM470_10005 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_10010 ENOG4105KBG Protein of unknown function (DUF1161) AM470_10015 ENOG4105M5Q UPF0482 protein AM470_10020 ENOG4105KK4 UPF0060 membrane protein AM470_10025 ENOG4105EMU Dehydrogenase AM470_10035 ENOG4105GAV receptor AM470_10040 ENOG4108S3W Anti-feci sigma factor, fecr AM470_10045 ENOG4108SF5 RNA Polymerase AM470_10050 ENOG4107QUY Guanine deaminase AM470_10055 ENOG4108MBX Secretion Protein AM470_10060 ENOG4108JJA ABC, transporter AM470_10100 ENOG4105DGW oligopeptidase A AM470_10105 ENOG4105CSP Major Facilitator Superfamily AM470_10110 ENOG4108UAU isochorismatase AM470_10115 ENOG4105RE0 Asp Glu hydantoin racemase AM470_10125 ENOG4105MSY salicylate hydroxylase AM470_10135 ENOG4108VHT MarR family transcriptional regulator AM470_10140 ENOG4108XHQ (2Fe-2S)-binding domain protein AM470_10145 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AM470_10150 ENOG4107U2T alpha beta AM470_10155 ENOG4105C5Q Transcriptional regulator AM470_10180 ENOG4108MBX Secretion Protein AM470_10185 ENOG4108JJA ABC, transporter AM470_10220 ENOG4105JQN Transcriptional regulator AM470_10225 ENOG4105EMU Dehydrogenase AM470_10230 ENOG4105Q2H domain protein AM470_10245 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AM470_10265 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AM470_10270 ENOG4105DU0 nucleoside hydrolase AM470_10280 ENOG4105F0F Oxalate decarboxylase AM470_10315 ENOG4105CPT Alpha beta hydrolase AM470_10365 ENOG4105JAB phenazine biosynthesis protein, phzf family AM470_10395 ENOG4105C6X Major Facilitator AM470_10405 ENOG4105PMV Membrane AM470_10415 ENOG4105CJN penicillin-binding protein AM470_10430 ENOG4105C8Q Methyl-accepting chemotaxis AM470_10435 ENOG41061RM osmotically inducible lipoprotein AM470_10450 ENOG410680R Protein of unknown function (DUF2592) AM470_10460 ENOG4105E98 transcriptional regulator DeoR family AM470_10465 ENOG4105D9R oxidoreductase AM470_10470 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_10490 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AM470_10495 ENOG4108TEB UPF0114 protein AM470_10510 ENOG4107S7U Sulfide dehydrogenase AM470_10520 ENOG4107QPB Beta-lactamase domain protein AM470_10525 ENOG4105DQ4 alcohol dehydrogenase AM470_10530 ENOG4105C26 Dehydrogenase AM470_10535 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AM470_10540 ENOG4105F87 Dehydratase AM470_10545 ENOG4105C2C drug resistance transporter, Bcr CflA AM470_10550 ENOG4105BZU Histidine kinase AM470_10570 ENOG4105DRR Transcriptional regulator, GntR family AM470_10580 ENOG4108MXF Alpha Beta Hydrolase AM470_10585 ENOG4105MXW flavin reductase domain protein, FMN-binding AM470_10590 ENOG4108M8W Monooxygenase AM470_10595 ENOG4105C26 Dehydrogenase AM470_10600 ENOG4105ETS cytosine purines uracil thiamine allantoin AM470_10605 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF AM470_10620 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) AM470_10625 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) AM470_10635 ENOG4108IGT Dipeptidase AM470_10640 ENOG4108PTX LysR family Transcriptional regulator AM470_10645 ENOG4105DY8 decarboxylase AM470_10650 ENOG4108JPW Aminotransferase AM470_10655 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM470_10665 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AM470_10675 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AM470_10680 ENOG4105BZU Histidine kinase AM470_10705 ENOG4107RZC phospholipase d AM470_10715 ENOG4105CBN LysR family transcriptional regulator AM470_10740 ENOG4105EMU Dehydrogenase AM470_10745 ENOG4105EMU Dehydrogenase AM470_10760 ENOG4107QP6 Xylose isomerase domain protein TIM barrel AM470_10765 ENOG4105CIB oxidoreductase Domain protein AM470_10800 ENOG4108UIN ybak prolyl-trna synthetase associated region AM470_10830 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AM470_10835 ENOG4105KVH Transcriptional regulator AM470_10840 ENOG4105E8G Major facilitator Superfamily AM470_10855 ENOG4105E93 esterase AM470_10860 ENOG4105E0K tonB-dependent siderophore receptor AM470_10865 ENOG4108SGR YheO domain-containing protein AM470_10870 ENOG4105D82 Glutamate dehydrogenase AM470_10875 ENOG4105CEY Amp-dependent synthetase and ligase AM470_10880 ENOG4108Z0Z intracellular protease Pfpi family AM470_10885 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM470_10920 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM470_10925 ENOG4105BZS acriflavin resistance protein AM470_10930 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM470_10935 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AM470_10940 ENOG4105DWY Agmatine deiminase AM470_10945 ENOG4105ETT transcriptional Regulator, LysR family AM470_10950 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AM470_10975 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AM470_10980 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AM470_10985 ENOG4108XHQ (2Fe-2S)-binding domain protein AM470_10990 ENOG4108Q3X Transcriptional regulator AM470_10995 ENOG4105CS2 ec 3.2.1.21 AM470_11005 ENOG4105D2S major facilitator superfamily AM470_11010 ENOG4105BZC d-serine deaminase AM470_11020 ENOG4105KCV RNA signal recognition particle 4.5S RNA AM470_11025 ENOG4105BZU Histidine kinase AM470_11050 ENOG4105C26 Dehydrogenase AM470_11055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AM470_11060 ENOG4105RPH Inner membrane protein YddG AM470_11065 ENOG4105C54 Major Facilitator superfamily AM470_11080 ENOG4105EGS Mechanosensitive ion channel AM470_11085 ENOG4105C5H ABC transporter AM470_11095 ENOG4105BZS acriflavin resistance protein AM470_11100 ENOG4105ECY inositol monophosphatase AM470_11105 ENOG41076HS cation diffusion facilitator family transporter AM470_11115 ENOG4105CJW magnesium transporter AM470_11120 ENOG4107QSI ABC, transporter AM470_11135 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AM470_11140 ENOG4105DXC membrane AM470_11185 ENOG4105C32 Amino acid ABC transporter (Permease) AM470_11190 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM470_11195 ENOG4105C0Z ABC transporter AM470_11200 ENOG4108IV0 ABC, transporter AM470_11215 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AM470_11235 ENOG4105CJ3 phosphate transporter AM470_11240 ENOG4105CSR polyphosphate kinase 2 AM470_11250 ENOG41061WM D-Alanyl-D-Alanine AM470_11255 ENOG4105DEN Luciferase family AM470_11260 ENOG4105CSW GntR family transcriptional regulator AM470_11270 ENOG41089BK Glutamine amido-transferase AM470_11280 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) AM470_11295 ENOG4105E70 isomerase AM470_11300 ENOG4105D2N Aldolase AM470_11310 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM470_11320 ENOG4105Q9Y Universal stress protein AM470_11325 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AM470_11330 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AM470_11335 ENOG4105C5D exported protein AM470_11340 ENOG4105D5Q Arginine ornithine antiporter AM470_11360 ENOG410642E Short chain dehydrogenase AM470_11365 ENOG4107EXC regulatoR AM470_11370 ENOG4105JJR Histidine kinase AM470_11375 ENOG4105CTD carboxy-peptidase AM470_11390 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap AM470_11395 ENOG4105CQ7 ATP-dependent helicase AM470_11400 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AM470_11405 ENOG4105WXT Conserved Protein AM470_11410 ENOG410689M (LipO)protein AM470_11415 ENOG4107H52 Dicarboxylate transport AM470_11430 ENOG4105C5I Dehydrogenase AM470_11435 ENOG41090X5 Heat shock protein hslJ AM470_11450 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AM470_11455 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AM470_11485 ENOG4107QSI ABC, transporter AM470_11495 ENOG4105KXI murein peptide amidase A AM470_11500 ENOG4107S8C mandelate racemase muconate lactonizing AM470_11505 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AM470_11515 ENOG4106K28 UPF0283 membrane protein AM470_11520 ENOG4105CM6 amino acid regulated cytosolic protein AM470_11525 ENOG4105NNG Peripheral inner membrane phage-shock protein AM470_11530 ENOG4105FM1 phage shock protein C AM470_11535 ENOG4105YYT phage shock protein B AM470_11540 ENOG41087YS Phage shock protein A AM470_11545 ENOG4105E51 psp operon transcriptional activator AM470_11555 ENOG4108Z0R Transferase AM470_11560 ENOG4107UHU Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) AM470_11565 ENOG4108J59 Extracellular solute-binding protein, family 5 AM470_11570 ENOG4108I5W peptide transport system, permease protein AM470_11575 ENOG4108EU3 peptide transport system, permease AM470_11580 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AM470_11585 ENOG4108JQ2 peptide transport system atp-binding protein AM470_11595 ENOG4105Q4T oxidoreductase AM470_11605 ENOG4105DUM transcriptional regulator, lysR family AM470_11610 ENOG4105DZ1 carboxypeptidase AM470_11615 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AM470_11630 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) AM470_11640 ENOG4105CH2 amidohydrolase AM470_11645 ENOG4105D22 carbon starvation protein AM470_11660 ENOG4105CKT filamentous hemagglutinin AM470_11705 ENOG41067NU AM470_11710 ENOG4105D5K Hemolysin activator protein AM470_11715 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM470_11720 ENOG4105F1A Pyruvate formate-lyase AM470_11725 ENOG4105C6N Formate acetyltransferase AM470_11730 ENOG4105N2W Transcriptional regulator AM470_11735 ENOG41061RM osmotically inducible lipoprotein AM470_11740 ENOG4108ZJT translation initiation factor, Sui1 AM470_11760 ENOG4105CFV Tetratricopeptide repeat protein AM470_11765 ENOG4105Q4A inner membrane protein yciS AM470_11770 ENOG4105CHR reductase AM470_11775 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AM470_11780 ENOG4105CNN ABC, transporter AM470_11785 ENOG4105C2J ABC transporter AM470_11795 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM470_11800 ENOG4108R85 Short chain dehydrogenase AM470_11805 ENOG4108IUS Transketolase AM470_11810 ENOG4108HHA Transketolase AM470_11815 ENOG4105E98 transcriptional regulator DeoR family AM470_11820 ENOG4105EYK Phosphatidylglycerophosphatase B AM470_11830 ENOG4107QM5 aconitate hydratase AM470_11835 ENOG4107R11 Transcriptional regulator AM470_11840 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM470_11845 ENOG4105RKX Protein of unknown function (DUF2498) AM470_11850 ENOG4105ERU peptidase AM470_11855 ENOG4105UBK short-chain dehydrogenase reductase AM470_11860 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AM470_11865 ENOG4105FE9 pseudouridine synthase AM470_11880 ENOG4107RTD sua5 ycio yrdc ywlc family protein AM470_11885 ENOG4105DB7 PHP domain protein AM470_11900 ENOG4107QYG anthranilate phosphoribosyltransferase AM470_11905 ENOG4105DK0 Indole-3-glycerol phosphate synthase AM470_11910 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AM470_11915 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AM470_11925 ENOG4105EIF outer membrane protein W AM470_11930 ENOG4105PI0 Ferredoxin AM470_11935 ENOG4108S3I UPF0259 membrane protein AM470_11945 ENOG4107835 probably involved in intracellular septation (By similarity) AM470_11950 ENOG4105NAU thioesterase Superfamily protein AM470_11960 ENOG4105WPN DNA integration recombination invertion protein AM470_11965 ENOG4105K9H YciI-like protein AM470_11975 ENOG4107NQ8 LysR family Transcriptional regulator AM470_11985 ENOG4105ETE Transcriptional regulator (LacI family AM470_12000 ENOG4105CMG Carbohydrate kinase AM470_12005 ENOG4105C2J ABC transporter AM470_12010 ENOG4105CNN ABC, transporter AM470_12015 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM470_12030 ENOG4108RMU ferritin dps family protein AM470_12040 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AM470_12045 ENOG4108W5H UPF0263 protein AM470_12050 ENOG4108JQ7 (ABC) transporter AM470_12055 ENOG4105C3U ABC transporter AM470_12060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM470_12065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM470_12070 ENOG4107QSI ABC, transporter AM470_12075 ENOG4108J59 Extracellular solute-binding protein, family 5 AM470_12080 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AM470_12085 ENOG4108EKI Dehydrogenase AM470_12090 ENOG4107104 thymidine kinase AM470_12105 ENOG4105C6Y Udp-glucose 6-dehydrogenase AM470_12110 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM470_12115 ENOG4105I93 response regulator AM470_12120 ENOG4105D78 K07001 NTE family protein AM470_12125 ENOG4105K5B UPF0225 protein AM470_12130 ENOG4105CIY formyltetrahydrofolate deformylase AM470_12155 ENOG4108URH decarboxylase AM470_12160 ENOG4105CGK Exodeoxyribonuclease III AM470_12165 ENOG4105M6F mutator MutT protein AM470_12170 ENOG4105MTM Protein of unknown function (DUF1496) AM470_12175 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM470_12180 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) AM470_12190 ENOG41069NU Nitroreductase AM470_12195 ENOG4105D07 Signal peptide peptidase, SppA AM470_12200 ENOG4105HDK L-asparaginase AM470_12205 ENOG4108RWI nicotinamidase AM470_12215 ENOG4105VUT cytoplasmic protein AM470_12220 ENOG4105E0X reductase AM470_12230 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM470_12235 ENOG4105DSB aldose 1-epimerase AM470_12240 ENOG4105GNX MltA-interacting MipA family protein AM470_12245 ENOG4105CYN Serine protein kinase AM470_12250 ENOG4106AKX UPF0229 protein AM470_12290 ENOG4105CNH Multidrug resistance protein MdtL AM470_12295 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AM470_12300 ENOG4105MWK D-amino acid dehydrogenase, small subunit AM470_12310 ENOG4108MEK Metal-binding protein YodA AM470_12315 ENOG4105ED1 spovr family AM470_12320 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) AM470_12325 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AM470_12330 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AM470_12335 ENOG4108ZZ3 UPF0260 protein AM470_12340 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AM470_12345 ENOG4105CVE Lytic murein transglycosylase AM470_12350 ENOG4105VNG YcgL domain-containing protein AM470_12355 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AM470_12360 ENOG4107QMS site-determining protein AM470_12365 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AM470_12370 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AM470_12375 ENOG4105CEY Amp-dependent synthetase and ligase AM470_12380 ENOG4105Y4Z Outer Membrane Lipoprotein AM470_12385 ENOG41072GX Peptidase M22 Glycoprotease AM470_12390 ENOG4105DVT helicase AM470_12395 ENOG4105M4H endoribonuclease L-psp AM470_12400 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) AM470_12405 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AM470_12410 ENOG4108UHU Aldolase AM470_12415 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AM470_12420 ENOG4106KNT transcriptional regulator AM470_12425 ENOG4105CA9 Pyruvate kinase AM470_12435 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AM470_12440 ENOG4105DR5 peptidase AM470_12445 ENOG4105NXV High-affinity zinc uptake system protein AM470_12450 ENOG4105FDK ABC transporter AM470_12455 ENOG4105FAV ABC, transporter AM470_12460 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AM470_12465 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AM470_12470 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AM470_12475 ENOG4105CDY transcriptional regulatory protein AM470_12480 ENOG4108TIT dATP pyrophosphohydrolase AM470_12485 ENOG4105C9M aspartyl-trna synthetase AM470_12495 ENOG4105D3W isochorismatase AM470_12500 ENOG41081XQ Conserved Protein AM470_12505 ENOG4105WJG Glutathione AM470_12510 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) AM470_12515 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AM470_12520 ENOG4108V1T peptidylprolyl cis-trans isomerase AM470_12530 ENOG4106N3A copper homeostasis protein cutc AM470_12535 ENOG4105C87 Aminotransferase class I and II AM470_12540 ENOG4106ZCM YecM protein AM470_12545 ENOG4105C75 arginyL-tRNA synthetase AM470_12550 ENOG4105CJR Integral membrane protein (MviN AM470_12555 ENOG4105EP9 oxidoreductase AM470_12560 ENOG4108YXG UPF0502 protein AM470_12565 ENOG4105D9U N-acetyltransferase AM470_12570 ENOG4105EV4 Multidrug resistance protein mdtH AM470_12580 ENOG4105E9S glutaredoxin 2 AM470_12590 ENOG4105F3T (LipO)protein AM470_12600 ENOG4105N5Z UPF0267 protein AM470_12605 ENOG4105X2V dna damage-inducible protein AM470_12610 ENOG4105C1J atp-dependent rna helicase AM470_12615 ENOG4105VEQ Cold shock protein AM470_12620 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AM470_12625 ENOG4105X5C UPF0181 protein AM470_12630 ENOG4105K64 Glycosyl transferase, family 2 AM470_12640 ENOG4105P8F nudix hydrolase AM470_12645 ENOG4105EJQ L-serine dehydratase AM470_12650 ENOG4107XTP (EAL) domain protein AM470_12655 ENOG4105EE5 Membrane protein terC AM470_12660 ENOG4108EQA pts system AM470_12665 ENOG4105ETZ PTS System AM470_12670 ENOG4105F3R pts system mannose fructose sorbose family iid AM470_12675 ENOG4108NK4 UPF0266 membrane protein AM470_12680 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) AM470_12685 ENOG4105DHI Methyltransferase AM470_12690 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AM470_12695 ENOG4105VEQ Cold shock protein AM470_12700 ENOG410610J Protein of unknown function (DUF2627) AM470_12715 ENOG4105C85 amino acid AM470_12735 ENOG41064PC AM470_12745 ENOG4105TIK AM470_12750 ENOG4105N4N Protein of unknown function (DUF2766) AM470_12755 ENOG4105XH3 AM470_12770 ENOG4105EUB pirin domain protein AM470_12775 ENOG4109066 lysm domain bon superfamily protein AM470_12780 ENOG4105UVW uncharacterized protein yebW AM470_12800 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AM470_12805 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) AM470_12810 ENOG4105C26 Dehydrogenase AM470_12815 ENOG4105F4X arginine AM470_12820 ENOG4105C8Y Acetylornithine aminotransferase AM470_12830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM470_12835 ENOG4105C4M (Ubiquinol oxidase) subunit I AM470_12840 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM470_12890 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AM470_12895 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AM470_12900 ENOG41076YT nitrate reductase, gamma subunit AM470_12905 ENOG4105R3A Nitrate reductase AM470_12910 ENOG4108IUE nitrate reductase beta subunit AM470_12915 ENOG4105CRU nitrate reductase, alpha subunit AM470_12930 ENOG4105CG5 Glycosyl transferase (Group 1 AM470_12955 ENOG4105D75 Capsular exopolysaccharide family AM470_12960 ENOG4105DAY polysaccharide export protein AM470_12965 ENOG4105ESV Glycosyl transferase, family 4 AM470_12970 ENOG4105DMT epimerase dehydratase AM470_12975 ENOG4108M3R transcriptional activator CadC AM470_12980 ENOG4105DQQ Major facilitator superfamily MFS_1 AM470_12985 ENOG4105BZU Histidine kinase AM470_12990 ENOG4105WH1 Two component transcriptional regulator luxr family AM470_12995 ENOG4105ID0 Putative invasin AM470_13010 ENOG4108JQ7 (ABC) transporter AM470_13015 ENOG4105C3U ABC transporter AM470_13020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM470_13025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM470_13035 ENOG4107R11 Transcriptional regulator AM470_13040 ENOG4108NH8 Cation transport protein AM470_13045 ENOG4105WS7 Cation transport regulator AM470_13050 ENOG4105Q26 Siderophore-interacting protein AM470_13055 ENOG4105EWV Sodium calcium exchanger membrane region AM470_13065 ENOG4105D5M phosphate starvation-inducible protein AM470_13085 ENOG4105CK7 Sodium proline symporter AM470_13090 ENOG4105C26 Dehydrogenase AM470_13095 ENOG4105CDA abc transporter atp-binding protein AM470_13100 ENOG4105E5Q amino acid AbC transporter AM470_13105 ENOG4105EAB amino acid AbC transporter AM470_13110 ENOG4105K6H D-cysteine desulfhydrase AM470_13115 ENOG4108M9K flagella biosynthesis protein FliZ AM470_13120 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM470_13135 ENOG4105DTS flagellar hook-associated AM470_13140 ENOG4105MQ3 flagellar protein FliS AM470_13145 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) AM470_13165 ENOG4105CC0 LysR family Transcriptional regulator AM470_13180 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AM470_13185 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AM470_13190 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AM470_13195 ENOG41090PJ Flagellar assembly protein AM470_13200 ENOG4108JIR Flagellum-specific ATP synthase AM470_13205 ENOG4105GSA Flagellar export protein flij AM470_13210 ENOG4105WF4 Flagellar hook-length control protein AM470_13215 ENOG4107ZI8 flagellar basal body-associated protein flil AM470_13220 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AM470_13225 ENOG4105DD5 Flagellar motor switch protein AM470_13235 ENOG4105CN7 Flagellar biosynthetic protein FliP AM470_13240 ENOG4105VS8 Flagellar biosynthetic protein fliq AM470_13245 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AM470_13260 ENOG4105DTJ flagellar hook-associated protein AM470_13265 ENOG4105E1Q flagellar hook-associated protein AM470_13275 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AM470_13290 ENOG4105CGA flagellar basal-body rod protein FlgG AM470_13295 ENOG4108KPB Flagellar basal-body rod protein FlgF AM470_13300 ENOG4105BZE flagellar hook protein, FlgE AM470_13305 ENOG4105W00 Flagellar hook capping protein AM470_13310 ENOG4108ZC9 flagellar basal-body rod protein flgc AM470_13320 ENOG4105CKS Flagella basal body P-ring formation protein flgA AM470_13325 ENOG4105M9M anti-sigma28 factor FlgM AM470_13330 ENOG4105QVD Flagella synthesis protein FlgN AM470_13350 ENOG4105D7B Flagellar biosynthesis protein flha AM470_13355 ENOG4105D00 flagellar biosynthetic protein flhB AM470_13360 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AM470_13365 ENOG4108VYJ response regulator receiver protein AM470_13375 ENOG4105BZU Histidine kinase AM470_13380 ENOG4105C8Q Methyl-accepting chemotaxis AM470_13385 ENOG4105C8Q Methyl-accepting chemotaxis AM470_13390 ENOG4108V3W Chemotaxis protein, CheW AM470_13395 ENOG4105CBS Chea signal transduction histidine kinase AM470_13400 ENOG4105ER2 Ompa motb domain protein AM470_13405 ENOG4107RD7 Flagellar Motor Protein, MotA AM470_13425 ENOG4105QZ5 OriC-binding nucleoid-associated protein AM470_13430 ENOG4108VA4 Universal stress protein AM470_13435 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AM470_13500 ENOG4106VK6 Flagellar motor protein AM470_13540 ENOG4108WC9 type VI secretion system effector, hcp1 family AM470_13600 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM470_13610 ENOG4105CS6 Rhs element vgr protein AM470_13615 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) AM470_13620 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AM470_13625 ENOG4107QN2 dihydrolipoyl dehydrogenase AM470_13635 ENOG4108KBJ Inner membrane protein YkgB AM470_13640 ENOG4108K01 transcriptional regulator AM470_13670 ENOG4108W2Y isochorismatase AM470_13675 ENOG4105ECQ AraC Family Transcriptional Regulator AM470_13680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM470_13690 ENOG4108S3W Anti-feci sigma factor, fecr AM470_13695 ENOG4108SF5 RNA Polymerase AM470_13700 ENOG4105X58 receptor AM470_13705 ENOG4105KT5 UmuD protein AM470_13740 ENOG4105FFC UPF0187 protein AM470_13745 ENOG4105EZR dyp-type peroxidase family protein AM470_13765 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) AM470_13785 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AM470_13790 ENOG4105KT7 mgtC SapB transporter AM470_13800 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F AM470_13805 ENOG4108MGI Transcriptional regulator AM470_13810 ENOG4105DY8 decarboxylase AM470_13825 ENOG4105VZF DsrB protein AM470_13830 ENOG4105VEQ Cold shock protein AM470_13855 ENOG4105EJC lysr family transcriptional regulator AM470_13860 ENOG4105VP5 Bacterial protein of unknown function (DUF937) AM470_13865 ENOG4105Y3U Transglycosylase-associated protein AM470_13875 ENOG4105D1S lipid A biosynthesis AM470_13880 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase AM470_13900 ENOG4105DXM phenylacetic acid degradation protein AM470_13905 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AM470_13910 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AM470_13915 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AM470_13920 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AM470_13925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM470_13930 ENOG4105E39 Enoyl-CoA hydratase AM470_13935 ENOG4108UKI Enoyl-CoA hydratase AM470_13940 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM470_13945 ENOG4108ZJI phenylacetic acid degradation protein AM470_13950 ENOG4105CHU acetyl-coa acetyltransferase AM470_13955 ENOG4105DZS Phenylacetate-CoA ligase AM470_13960 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AM470_13965 ENOG4108Z0R Transferase AM470_13970 ENOG4105C85 amino acid AM470_13975 ENOG4105CGF Aromatic amino acid aminotransferase AM470_13990 ENOG4105CC0 LysR family Transcriptional regulator AM470_14010 ENOG4105C26 Dehydrogenase AM470_14025 ENOG4105EQ2 LysR family Transcriptional regulator AM470_14030 ENOG4105CPC Aldo Keto reductase AM470_14040 ENOG4105CHB tonB-dependent Receptor AM470_14045 ENOG4105DZG Dehydrogenase AM470_14080 ENOG4105UGQ Fimbrial AM470_14090 ENOG4108FZ9 Chaperone AM470_14095 ENOG4106PG1 outer membrane usher protein AM470_14100 ENOG4108RQP Major type 1 subunit fimbrin AM470_14115 ENOG4105UQX Mate efflux family protein AM470_14145 ENOG4107HP6 Transcriptional regulator AM470_14150 ENOG4107QP7 CoA-transferase subunit A AM470_14155 ENOG4107QNJ CoA-transferase subunit B AM470_14160 ENOG4105CHU acetyl-coa acetyltransferase AM470_14165 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AM470_14170 ENOG4105F2Z 3-oxoadipate enol-lactonase AM470_14175 ENOG4105DDW LysR family Transcriptional regulator AM470_14180 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha AM470_14185 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta AM470_14195 ENOG4105D2S major facilitator superfamily AM470_14210 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) AM470_14240 ENOG4105ETU transcriptional activator (TenA AM470_14245 ENOG4108YI8 ABC transporter AM470_14250 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AM470_14255 ENOG4107Z6I Thiamine biosynthesis protein AM470_14265 ENOG4107RES phosphoglycerol transferase I AM470_14270 ENOG4105FYV Amp nucleosidase AM470_14285 ENOG4108T9Y Inner membrane protein ydcZ AM470_14290 ENOG4108Z7F N-acetyltransferase AM470_14300 ENOG410900S Protein of unknown function (DUF2623) AM470_14310 ENOG4105W8I Transcriptional regulator AM470_14320 ENOG4105DKP glycosyl transferase, family 9 AM470_14340 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AM470_14345 ENOG4105EXG Transcriptional regulator AM470_14350 ENOG4105CF1 Alkylated DNA repair protein AM470_14355 ENOG4105DTR rard protein AM470_14360 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AM470_14365 ENOG4105E4F Isochorismate synthase AM470_14375 ENOG4105D6F Phosphatase AM470_14380 ENOG4107QPK )-transporter AM470_14385 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AM470_14395 ENOG4105CHY citrate lyase, alpha AM470_14400 ENOG4105CI0 Citrate lyase AM470_14405 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) AM470_14410 ENOG4105DUA (citrate (pro-3S)-lyase ligase AM470_14415 ENOG4106YYS transcriptional regulatory protein AM470_14420 ENOG4105CNT hydrolase family 2 AM470_14430 ENOG4105E1F short-chain dehydrogenase reductase AM470_14435 ENOG4105CF7 AraC family transcriptional regulator AM470_14475 ENOG4105ETT transcriptional Regulator, LysR family AM470_14480 ENOG4107WYG Transcriptional regulator, luxr family AM470_14490 ENOG4105DIK (ABC) transporter AM470_14495 ENOG4105EHG Permease protein AM470_14510 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_14515 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase AM470_14530 ENOG4107RGH Aldehyde dehydrogenase AM470_14535 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AM470_14570 ENOG4105EA8 2-Nitropropane dioxygenase AM470_14590 ENOG4105C54 Major Facilitator superfamily AM470_14615 ENOG4108IV0 ABC, transporter AM470_14620 ENOG4105C0Z ABC transporter AM470_14625 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM470_14630 ENOG4105C32 Amino acid ABC transporter (Permease) AM470_14660 ENOG4105CSH Transporter AM470_14670 ENOG4105F04 LysR family Transcriptional regulator AM470_14675 ENOG41080IJ Diacylglycerol kinase AM470_14695 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AM470_14700 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM470_14705 ENOG4108GH0 ATP-binding protein yghT AM470_14710 ENOG4108NDC ATP-binding protein yghS AM470_14715 ENOG4106FPV ATP-binding protein YghR AM470_14720 ENOG4108S55 polysaccharide biosynthesis protein AM470_14730 ENOG4108UUE Transcriptional regulator AM470_14735 ENOG4108M8S permease YjgP YjgQ family protein AM470_14765 ENOG410810E transcriptional regulator, lysR family AM470_14785 ENOG4105FKQ transcriptional regulator AM470_14790 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AM470_14795 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase AM470_14800 ENOG4105CMG Carbohydrate kinase AM470_14805 ENOG4105CNN ABC, transporter AM470_14815 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM470_14820 ENOG4105CPQ Dehydrogenase AM470_14830 ENOG4105CH2 amidohydrolase AM470_14835 ENOG4105E89 ABC transporter AM470_14840 ENOG41090HJ UPF0265 protein AM470_14845 ENOG4105DR8 Membrane AM470_14850 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM470_14875 ENOG4105Y50 Virulence Protein AM470_14885 ENOG4108X9F tail fiber protein AM470_14985 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AM470_14990 ENOG4105EFC phage portal protein HK97 family AM470_15025 ENOG4105KUS lysozyme AM470_15065 ENOG4105CFI type iii restriction protein res subunit AM470_15075 ENOG4108S1U AM470_15140 ENOG4105CJB Exodeoxyribonuclease I AM470_15145 ENOG4105CUB amino acid AM470_15155 ENOG4105CFQ glutamine synthetase AM470_15160 ENOG4107VRI Transcriptional regulator AM470_15165 ENOG4105C2J ABC transporter AM470_15170 ENOG4105CNN ABC, transporter AM470_15175 ENOG4105D05 Receptor AM470_15190 ENOG4105EHG Permease protein AM470_15195 ENOG4105BZU Histidine kinase AM470_15200 ENOG4108IQI permease AM470_15205 ENOG4105DUM transcriptional regulator, lysR family AM470_15215 ENOG4105HMI Membrane AM470_15220 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AM470_15225 ENOG4105DM4 PTS System AM470_15230 ENOG4105DE4 1-phosphofructokinase AM470_15235 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AM470_15245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AM470_15250 ENOG4105CUW cytochrome C-TYPE protein AM470_15255 ENOG4107QY8 reductase AM470_15265 ENOG4105KRS Proteinase inhibitor AM470_15275 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AM470_15280 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AM470_15285 ENOG4105DEI Mannitol dehydrogenase AM470_15295 ENOG4105CKI cobalamin synthesis protein AM470_15300 ENOG41076MN Phosphoesterase, PA-phosphatase related AM470_15310 ENOG4107TT5 NLP P60 protein AM470_15315 ENOG4105CXC rtn protein AM470_15320 ENOG4105E43 Extracellular solute-binding protein, family 5 AM470_15325 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AM470_15330 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AM470_15335 ENOG4108JQ5 ABC transporter AM470_15340 ENOG4105HG6 AM470_15345 ENOG4105C2C drug resistance transporter, Bcr CflA AM470_15350 ENOG4105I08 Pseudouridine synthase AM470_15355 ENOG4105CFI type iii restriction protein res subunit AM470_15360 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AM470_15365 ENOG4106V8H Nucleoid-associated protein AM470_15370 ENOG4105PAN UPF0352 protein AM470_15375 ENOG4105E68 Sulfatase AM470_15385 ENOG4105MSY salicylate hydroxylase AM470_15390 ENOG4108RXX maleylacetoacetate isomerase AM470_15415 ENOG4105DB1 molybdopterin oxidoreductase AM470_15420 ENOG4106WHD Tetrathionate reductase AM470_15425 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM470_15430 ENOG4106AFQ Histidine kinase AM470_15435 ENOG4108ZXC Two component transcriptional regulator, luxr family AM470_15440 ENOG4105Y50 Virulence Protein AM470_15455 ENOG4105KKI DNA-binding transcriptional activator OsmE AM470_15470 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AM470_15480 ENOG4105M0C cytoplasmic protein AM470_15485 ENOG4106UW1 Major Facilitator superfamily AM470_15490 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC AM470_15495 ENOG41068CG regulatoR AM470_15500 ENOG4105BZU Histidine kinase AM470_15505 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM470_15510 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AM470_15515 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM470_15520 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM470_15525 ENOG4105XPH Ferredoxin AM470_15550 ENOG4105E0U tyrosine-specific transport protein AM470_15555 ENOG4108UII YfaZ family AM470_15560 ENOG4105CH6 catalase AM470_15565 ENOG4105CEY Amp-dependent synthetase and ligase AM470_15575 ENOG4108IPT Naphthoate synthase AM470_15580 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AM470_15585 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AM470_15590 ENOG4105TNS Conserved Protein AM470_15595 ENOG4105CPQ Dehydrogenase AM470_15600 ENOG4105CHR reductase AM470_15605 ENOG4105K2J Transcriptional regulator AM470_15610 ENOG4108UQ5 membrane protein YcdZ AM470_15620 ENOG4105HEI LysR family (Transcriptional regulator AM470_15625 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM470_15630 ENOG4105C8S subunit m AM470_15635 ENOG4105D65 subunit l AM470_15640 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM470_15645 ENOG4107UFS subunit j AM470_15655 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AM470_15660 ENOG4108IEH NADH dehydrogenase subunit g AM470_15665 ENOG4107QIZ NADH dehydrogenase AM470_15670 ENOG4105GKE subunit e AM470_15675 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM470_15680 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM470_15685 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AM470_15690 ENOG4107NQ8 LysR family Transcriptional regulator AM470_15695 ENOG4105CHM Aminotransferase AM470_15700 ENOG4105DK2 UPF0207 protein AM470_15705 ENOG4107QWE )-transporter AM470_15710 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AM470_15715 ENOG4105XWI UPF0304 protein AM470_15720 ENOG4105PQ6 UPF0208 membrane protein AM470_15725 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AM470_15730 ENOG4105C6K Malic enzyme AM470_15735 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AM470_15740 ENOG4108HHA Transketolase AM470_15745 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC AM470_15755 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia AM470_15760 ENOG4105K2J Transcriptional regulator AM470_15765 ENOG4105PTV Nudix Hydrolase AM470_15770 ENOG4108RE9 Phosphodiesterase AM470_15775 ENOG4105CYM Glutathione S-transferase AM470_15780 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase AM470_15785 ENOG4105ECP epimerase AM470_15790 ENOG4108JEH abc transporter atp-binding protein AM470_15795 ENOG4106YG3 ABC transporter AM470_15800 ENOG4105DSP amino acid AbC transporter AM470_15805 ENOG4105E89 ABC transporter AM470_15810 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AM470_15815 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AM470_15820 ENOG4105E96 Colicin v production protein AM470_15825 ENOG4108S3P Sporulation domain protein AM470_15830 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AM470_15835 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AM470_15840 ENOG4105DQR SNARE associated Golgi AM470_15850 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM470_15855 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AM470_15865 ENOG410631K Membrane AM470_15870 ENOG4105DHQ Histidine kinase AM470_15900 ENOG4105EQK -acetyltransferase AM470_15910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM470_15915 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AM470_15925 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AM470_15935 ENOG4106WZ1 flagella biosynthesis regulator AM470_15955 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AM470_15960 ENOG4105F4P )-transporter AM470_15965 ENOG4105CJ2 (LipO)protein AM470_15970 ENOG4105XCM membrane LIPOPROTEIN AM470_15975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM470_15980 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AM470_15985 ENOG4105MH2 YfcL protein AM470_15990 ENOG4108BPE -transporting atpase AM470_15995 ENOG4105EJ9 Membrane AM470_16005 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AM470_16010 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AM470_16015 ENOG4108DG9 Smr protein MutS2 AM470_16020 ENOG4108BY2 phosphohistidine phosphatase AM470_16025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM470_16030 ENOG4105CHU acetyl-coa acetyltransferase AM470_16035 ENOG4105KZW UPF0381 protein AM470_16040 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AM470_16045 ENOG410903C (LipO)protein AM470_16050 ENOG4105KWW Biogenesis protein AM470_16055 ENOG4105KWW Biogenesis protein AM470_16060 ENOG4107QX9 Thiol disulfide interChange protein AM470_16065 ENOG4105DA4 cytochrome c-type biogenesis protein AM470_16070 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AM470_16075 ENOG4105X3C heme exporter protein AM470_16080 ENOG41060IM Heme exporter protein AM470_16085 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AM470_16095 ENOG4105S64 Formate nitrite transporter AM470_16105 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AM470_16110 ENOG4105UEI Transcriptional Regulator AraC Family AM470_16125 ENOG4105WH1 Two component transcriptional regulator luxr family AM470_16135 ENOG4105W8I Transcriptional regulator AM470_16145 ENOG4108Q5Y Membrane AM470_16160 ENOG4105CVE Lytic murein transglycosylase AM470_16175 ENOG4105CND Glycosyl transferase, family 2 AM470_16180 ENOG4107BJW polysaccharide deacetylase AM470_16185 ENOG4108TUY outer membrane protein PgaA AM470_16190 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin AM470_16200 ENOG4108VKM cytochrome b561 AM470_16205 ENOG4105CHM Aminotransferase AM470_16215 ENOG41072TH Protein of unknown function (DUF1479) AM470_16220 ENOG4108HRK Histidine kinase AM470_16225 ENOG4105DY9 regulatoR AM470_16230 ENOG41062C6 Protein of unknown function (DUF2502) AM470_16235 ENOG4105FCD Major Facilitator AM470_16260 ENOG4105C5Q Transcriptional regulator AM470_16265 ENOG4107RA9 decarboxylase AM470_16270 ENOG4105CPC Aldo Keto reductase AM470_16275 ENOG41062C6 Protein of unknown function (DUF2502) AM470_16280 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AM470_16285 ENOG4105D9N nucleoside AM470_16295 ENOG4106EAR Fimbrial protein AM470_16300 ENOG4108VCD Chaperone AM470_16305 ENOG4105CW0 outer membrane usher protein AM470_16330 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AM470_16360 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AM470_16365 ENOG4105DQ5 transport system permease protein AM470_16370 ENOG4105TVJ transport system, permease AM470_16375 ENOG4105E0A ABC, transporter AM470_16380 ENOG4105E93 esterase AM470_16385 ENOG4105E0K tonB-dependent siderophore receptor AM470_16390 ENOG4105DEF Extracellular solute-binding protein, family 5 AM470_16395 ENOG4105C7K acetolactate synthase AM470_16410 ENOG4107FQ9 ethanolamine ammonia-lyase AM470_16415 ENOG4105CPD ethanolamine ammonia-lyase AM470_16430 ENOG4108M0I Transcriptional regulator AM470_16435 ENOG4105DHU Bile acid AM470_16440 ENOG4105VRT cytoplasmic protein AM470_16445 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AM470_16450 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) AM470_16455 ENOG4105EXN Sulfate transport protein CysZ AM470_16460 ENOG4105C6T cysteine synthase AM470_16465 ENOG4105KZ7 phosphocarrier protein hpr AM470_16470 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AM470_16475 ENOG4105C5Y PTS System AM470_16480 ENOG4105E0F Histidine kinase AM470_16485 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM470_16490 ENOG4105C6T cysteine synthase AM470_16500 ENOG4105ECW sulfate abc transporter AM470_16505 ENOG4108I5D sulfate abc transporter AM470_16510 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AM470_16515 ENOG4105EZR dyp-type peroxidase family protein AM470_16520 ENOG4105E7K (LipO)protein AM470_16525 ENOG4105QZU Inner membrane protein YfeZ AM470_16530 ENOG4105H4F exported protein AM470_16535 ENOG4108R6G acetyltransferase AM470_16540 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase AM470_16545 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AM470_16550 ENOG4108UPT UPF0178 protein AM470_16555 ENOG41063SR receptor AM470_16560 ENOG4105CUG Oligopeptidase b AM470_16575 ENOG4108IQI permease AM470_16580 ENOG4107QK5 Homocysteine s-methyltransferase AM470_16585 ENOG4105C6K Malic enzyme AM470_16610 ENOG4105EQ1 Transcriptional regulator AM470_16615 ENOG4108M1A Chitin-binding protein AM470_16620 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM470_16625 ENOG4105CV1 Transketolase (EC 2.2.1.1) AM470_16630 ENOG4107VIJ nudix hydrolase AM470_16640 ENOG4105BZU Histidine kinase AM470_16645 ENOG4105WH1 Two component transcriptional regulator luxr family AM470_16655 ENOG4105BZS acriflavin resistance protein AM470_16665 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AM470_16675 ENOG4105KUZ arsenate reductase AM470_16680 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AM470_16690 ENOG4105XYK UPF0370 protein AM470_16695 ENOG4106KED esterase YpfH AM470_16700 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AM470_16705 ENOG4105CGZ zinc metallopeptidase AM470_16710 ENOG4105C8V SAICAR synthetase AM470_16715 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM470_16720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AM470_16725 ENOG4105RH4 Glycine cleavage system transcriptional repressor AM470_16730 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AM470_16735 ENOG4105C02 permease AM470_16750 ENOG4108NS2 receptor AM470_16765 ENOG4105EW9 transcriptional regulator AsnC family AM470_16780 ENOG4105ERG peptidase m48, ste24p AM470_16785 ENOG4105K89 arsenate reductase AM470_16790 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) AM470_16800 ENOG4105Y3U Transglycosylase-associated protein AM470_16810 ENOG4105C2W permease AM470_16815 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AM470_16820 ENOG4105CXB phosphoribosylaminoimidazole synthetase AM470_16825 ENOG4108V3E phosphoribosylglycinamide formyltransferase AM470_16830 ENOG4108MK9 spermidine N(1)-acetyltransferase AM470_16850 ENOG4105CKT filamentous hemagglutinin AM470_16855 ENOG4105D5K Hemolysin activator protein AM470_16875 ENOG4105C8U phosphate abc transporter AM470_16880 ENOG4105C8U phosphate abc transporter AM470_16885 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AM470_16890 ENOG4105C9X ppx gppa phosphatase AM470_16900 ENOG4105CJW magnesium transporter AM470_16905 ENOG4105BZU Histidine kinase AM470_16920 ENOG4105R8A Heat shock protein AM470_16935 ENOG4105CPC Aldo Keto reductase AM470_16940 ENOG4105ENT Efflux transporter rnd family, mfp subunit AM470_16945 ENOG4105BZS acriflavin resistance protein AM470_16950 ENOG4105BZS acriflavin resistance protein AM470_16955 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_16960 ENOG4105EB3 Histidine kinase AM470_16965 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM470_16980 ENOG4105KWI UPF0339 protein AM470_16985 ENOG4105CFP Peptidase U32 AM470_16990 ENOG4107TE5 Lipid kinase AM470_17000 ENOG4105CPQ Dehydrogenase AM470_17005 ENOG4108I5G Major Facilitator superfamily AM470_17010 ENOG4105DEI Mannitol dehydrogenase AM470_17020 ENOG4107XBN GntR Family Transcriptional Regulator AM470_17025 ENOG4105EIE fructose-bisphosphate aldolase AM470_17035 ENOG410787A Pts system, glucitol sorbitol-specific AM470_17040 ENOG4105DZY Pts system, glucitol sorbitol-specific AM470_17045 ENOG4105VI0 Pts system, glucitol sorbitol-specific AM470_17050 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase AM470_17055 ENOG4105J92 DNA-binding transcriptional activator GutM AM470_17060 ENOG410804X Transcriptional regulator AM470_17070 ENOG4108ZGU inhibitor of vertebrate lysozyme AM470_17075 ENOG4105DWF phosphomethylpyrimidine kinase AM470_17080 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AM470_17115 ENOG4105FE9 pseudouridine synthase AM470_17135 ENOG4105BZU Histidine kinase AM470_17145 ENOG4105KVH Transcriptional regulator AM470_17155 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AM470_17160 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AM470_17170 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AM470_17180 ENOG4105DPW Major facilitator superfamily MFS_1 AM470_17185 ENOG4105ETE Transcriptional regulator (LacI family AM470_17190 ENOG4105D4Y metalloprotease AM470_17200 ENOG4105VPD cellular component movement AM470_17210 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AM470_17215 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM470_17220 ENOG4105N21 Membrane AM470_17225 ENOG4105CUT histidyl-tRNA synthetase AM470_17230 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AM470_17235 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) AM470_17245 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AM470_17250 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AM470_17255 ENOG4105YYA enhanced serine sensitivity protein SseB AM470_17260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AM470_17265 ENOG4105WVQ Fe-S assembly protein IscX AM470_17270 ENOG4108ZIT Ferredoxin, 2FE-2S AM470_17275 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB AM470_17280 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) AM470_17285 ENOG4108Z4V iron-sulfur cluster assembly AM470_17290 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AM470_17295 ENOG4105C3J Cysteine desulfurase AM470_17300 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AM470_17310 ENOG4105ECY inositol monophosphatase AM470_17315 ENOG4105D7X high-affinity nickel-transporter AM470_17320 ENOG41065CD Exported protein AM470_17325 ENOG4108MN2 Stationary phase inducible protein CsiE AM470_17330 ENOG4105D8G Major Facilitator superfamily AM470_17335 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AM470_17340 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM470_17355 ENOG4105C26 Dehydrogenase AM470_17360 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AM470_17365 ENOG4105D81 ABC transporter, permease AM470_17370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_17375 ENOG4107TYH extracellular solute-binding protein family 1 AM470_17380 ENOG4105C26 Dehydrogenase AM470_17385 ENOG4107RSM transcriptional regulator AM470_17395 ENOG4108YZA Nitrogen regulatory protein pii AM470_17400 ENOG4105C4K Nad synthetase AM470_17405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM470_17410 ENOG4108SKK alpha helix protein AM470_17415 ENOG4107WP9 Histidine kinase AM470_17425 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AM470_17430 ENOG4108Z6B deaminase AM470_17440 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB AM470_17450 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AM470_17455 ENOG4106G6Q Transcriptional regulator AM470_17460 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AM470_17465 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AM470_17470 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AM470_17475 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) AM470_17480 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AM470_17485 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AM470_17490 ENOG4105C3F Signal peptidase i AM470_17495 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AM470_17505 ENOG4105WMJ Positive regulator of sigma E, RseC MucC AM470_17510 ENOG4105VQK sigma E regulatory protein, MucB RseB AM470_17525 ENOG4108IYU L-aspartate oxidase AM470_17530 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AM470_17535 ENOG4105C1J atp-dependent rna helicase AM470_17555 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AM470_17560 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AM470_17565 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AM470_17570 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AM470_17575 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM470_17580 ENOG4105VDB UPF0125 protein AM470_17585 ENOG4108Z1B Cyclase dehydrase AM470_17590 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AM470_17600 ENOG4105DFP Integrase AM470_17610 ENOG4105ZTC transcriptional activator, Ogr delta AM470_17730 ENOG4105S5I Membrane AM470_17745 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AM470_17770 ENOG410830R acetyltransferase AM470_17780 ENOG4108SB3 DoxX Family AM470_17795 ENOG4108SAJ Protein of unknown function (DUF1198) AM470_17800 ENOG4108WMJ Protein of unknown function (DUF2002) AM470_17805 ENOG4105F9N Major Facilitator Superfamily AM470_17810 ENOG4105JQN Transcriptional regulator AM470_17815 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_17830 ENOG4105TNS Conserved Protein AM470_17840 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AM470_17845 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AM470_17850 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AM470_17860 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM470_17880 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AM470_17885 ENOG4105Q2H domain protein AM470_17895 ENOG4105D2K citrate carrier protein AM470_17900 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM470_17905 ENOG4106YYS transcriptional regulatory protein AM470_17910 ENOG4108IJ7 Glycine betaine AM470_17915 ENOG4108HQS Glycine betaine AM470_17920 ENOG4105GIJ Glycine betaine AM470_17925 ENOG4106NZI LysR family Transcriptional regulator AM470_17930 ENOG4105EQ0 Major Facilitator superfamily AM470_17935 ENOG4108UMN azlc family AM470_17940 ENOG4105ZED uncharacterized protein ygaH AM470_17945 ENOG4105NTK Transcriptional repressor Mpra AM470_17955 ENOG4105CW7 secretion protein, HlyD family AM470_17960 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_17965 ENOG4105EIB trna rrna methyltransferase AM470_17970 ENOG4105K63 Thioredoxin AM470_17975 ENOG4106IUH DTW domain containing protein AM470_17980 ENOG4105CD5 CoA-binding domain protein AM470_17985 ENOG4105JIM Phosphatidylserine synthase AM470_17990 ENOG4105CSH Transporter AM470_18025 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AM470_18035 ENOG4108UMI ABC transporter, permease AM470_18040 ENOG4105D01 (LipO)protein AM470_18045 ENOG4108R8X outer membrane lipoprotein AM470_18050 ENOG4108R96 Methyltransferase, YaeB family AM470_18055 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AM470_18060 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AM470_18065 ENOG4108YZN class I peptide chain release factor AM470_18070 ENOG4108VWS Yaeq family AM470_18080 ENOG4105M1T rho-binding antiterminator AM470_18085 ENOG4105N7H Cytochrome AM470_18090 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AM470_18095 ENOG4105DUX Transporter AM470_18100 ENOG4105CXN decarboxylase AM470_18105 ENOG4105D5Q Arginine ornithine antiporter AM470_18110 ENOG4108M3R transcriptional activator CadC AM470_18115 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AM470_18120 ENOG4105CXN decarboxylase AM470_18125 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AM470_18130 ENOG4105C0B DNA polymerase III (alpha subunit) AM470_18135 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AM470_18140 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM470_18145 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM470_18150 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AM470_18155 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM470_18160 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AM470_18165 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AM470_18170 ENOG4105DZP Membrane-associated zinc metalloprotease AM470_18175 ENOG4105KNE Phosphatidate cytidylyltransferase AM470_18180 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AM470_18185 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AM470_18190 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AM470_18195 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AM470_18200 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AM470_18205 ENOG4105CE9 30S ribosomal protein S2 AM470_18210 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AM470_18215 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AM470_18225 ENOG4108T8E UPF0325 protein AM470_18230 ENOG4105QDK Flavodoxin AM470_18235 ENOG4105DR9 pseudouridine synthase AM470_18240 ENOG4108JQB penicillin-binding protein 1C AM470_18245 ENOG4105DN3 alpha-2-macroglobulin domain protein AM470_18250 ENOG4105WP7 tRNA pseudouridine synthase C AM470_18255 ENOG4107RGD Major Facilitator superfamily AM470_18270 ENOG4105EWT decarboxylase family AM470_18275 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease AM470_18280 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AM470_18285 ENOG4105M08 Membrane AM470_18290 ENOG4105ETT transcriptional Regulator, LysR family AM470_18295 ENOG4105M5B (LipO)protein AM470_18300 ENOG4105C9B Cysteine desulfurase AM470_18305 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AM470_18310 ENOG4105CUZ uba thif-type nad fad binding protein AM470_18315 ENOG4105CA3 membrane-bound lytic murein transglycosylase AM470_18335 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AM470_18340 ENOG4107QZM n-acetylglutamate synthase AM470_18345 ENOG4107QYX exodeoxyribonuclease v alpha AM470_18350 ENOG4107QKA exodeoxyribonuclease V beta AM470_18355 ENOG4107QXK peptidase AM470_18360 ENOG4105DSY exodeoxyribonuclease V, gamma AM470_18380 ENOG4105IPU prepilin peptidase dependent protein A AM470_18385 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AM470_18390 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AM470_18395 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AM470_18400 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AM470_18405 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) AM470_18410 ENOG4105EE5 Membrane protein terC AM470_18415 ENOG4105SUV lipoprotein YgdR AM470_18420 ENOG4105CPC Aldo Keto reductase AM470_18425 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) AM470_18430 ENOG4105CEY Amp-dependent synthetase and ligase AM470_18445 ENOG41060NJ transcriptional regulator AM470_18460 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AM470_18465 ENOG4105RQF LysR family Transcriptional regulator AM470_18470 ENOG4105EJC lysr family transcriptional regulator AM470_18490 ENOG4105CQ0 ABC transporter AM470_18500 ENOG4105F3R pts system mannose fructose sorbose family iid AM470_18505 ENOG4105ETZ PTS System AM470_18510 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB AM470_18515 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of AM470_18520 ENOG4105E98 transcriptional regulator DeoR family AM470_18525 ENOG4105DJ2 Major Facilitator Superfamily AM470_18535 ENOG4105IBP Cyclic peptide transporter AM470_18540 ENOG4108W9T type 1 fimbriae regulatory protein AM470_18545 ENOG4108N8T regulatoR AM470_18550 ENOG41068CG regulatoR AM470_18555 ENOG4106318 fimbrial-like protein YdeR AM470_18560 ENOG4105MHR Fimbrial protein AM470_18565 ENOG4105CW0 outer membrane usher protein AM470_18570 ENOG4108VCD Chaperone AM470_18575 ENOG4106UCC Fimbrial protein AM470_18580 ENOG4108W9T type 1 fimbriae regulatory protein AM470_18590 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM470_18595 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM470_18605 ENOG4105DJY efflux transporter, rnd family, mfp subunit AM470_18610 ENOG4105BZ1 (ABC) transporter AM470_18630 ENOG4105JQN Transcriptional regulator AM470_18635 ENOG4105DAA L-lactate AM470_18640 ENOG4105DMF Dehydrogenase AM470_18650 ENOG4107RGD Major Facilitator superfamily AM470_18660 ENOG4105C94 Transporter AM470_18665 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AM470_18670 ENOG4108JJ7 ABC transporter AM470_18675 ENOG4105UEI Transcriptional Regulator AraC Family AM470_18680 ENOG4108K5P (LipO)protein AM470_18685 ENOG4108YK4 Acid-resistance membrane protein AM470_18705 ENOG4105C9B Cysteine desulfurase AM470_18715 ENOG4105C94 Transporter AM470_18725 ENOG4105CRK lysyL-tRNA synthetase AM470_18735 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AM470_18740 ENOG4105T95 Thiol disulfide interChange protein AM470_18745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM470_18750 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AM470_18755 ENOG4105CT7 inner membrane cred family protein AM470_18760 ENOG4105EB3 Histidine kinase AM470_18765 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM470_18775 ENOG4105Y75 tpr repeat protein AM470_18780 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) AM470_18790 ENOG4108UT2 hemolysin iii AM470_18810 ENOG4108RVA ribokinase AM470_18815 ENOG4107TFG D-allose kinase AM470_18820 ENOG4105UP7 3-epimerase AM470_18830 ENOG4105CNN ABC, transporter AM470_18835 ENOG4105C2J ABC transporter AM470_18845 ENOG4105E98 transcriptional regulator DeoR family AM470_18885 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AM470_18915 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AM470_18920 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AM470_18925 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AM470_18930 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AM470_18935 ENOG4105D0A hydroxylase AM470_18940 ENOG4107RAQ aminopeptidase AM470_18945 ENOG4105E07 UPF0149 protein AM470_18950 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AM470_18960 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AM470_18965 ENOG4108JQ1 Dehydrogenase AM470_18970 ENOG4105E66 phosphoriboisomerase A AM470_18975 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AM470_18980 ENOG4105MPN Membrane AM470_18985 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AM470_18990 ENOG4105D3G Pseudouridine synthase AM470_18995 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AM470_19005 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AM470_19015 ENOG4105D64 Mechanosensitive ion channel AM470_19025 ENOG4105D2N Aldolase AM470_19030 ENOG4105BZA Phosphoglycerate kinase AM470_19035 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM470_19040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_19045 ENOG4107Z33 ABC transporter, permease AM470_19060 ENOG4105CWM branched-chain amino acid transport system II carrier protein AM470_19065 ENOG4105CV1 Transketolase (EC 2.2.1.1) AM470_19070 ENOG4108K0D peptidase, M48 AM470_19085 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) AM470_19090 ENOG4105CHR reductase AM470_19110 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase AM470_19120 ENOG4108FUF Transcriptional regulator, IclR family AM470_19125 ENOG4105CHR reductase AM470_19145 ENOG4105DJB Major Facilitator Superfamily AM470_19150 ENOG4105WI6 cell killing protein encoded within cryptic prophage AM470_19155 ENOG4105CYW agmatinase AM470_19160 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AM470_19165 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AM470_19180 ENOG4105S6R Iron-hydroxamate transporter permease subunit AM470_19185 ENOG4105J76 Periplasmic binding protein AM470_19190 ENOG4105E0A ABC, transporter AM470_19195 ENOG4105E0K tonB-dependent siderophore receptor AM470_19200 ENOG4105BZ4 penicillin-binding protein AM470_19205 ENOG4105CQ7 ATP-dependent helicase AM470_19210 ENOG4107XID 2'-5' rna ligase AM470_19215 ENOG4105PW4 Sugar fermentation stimulation protein homolog AM470_19225 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AM470_19230 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AM470_19235 ENOG4105DJ0 Poly(A) Polymerase AM470_19240 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AM470_19245 ENOG4105DHQ Histidine kinase AM470_19250 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM470_19255 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AM470_19260 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AM470_19265 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AM470_19270 ENOG4107BJW polysaccharide deacetylase AM470_19275 ENOG4105E3A (ABC) transporter AM470_19280 ENOG4105DA5 (ABC) transporter AM470_19285 ENOG41077A9 carbonic anhydrase AM470_19290 ENOG4108UGV hypoxanthine phosphoribosyltransferase AM470_19295 ENOG4105E3B Multicopper oxidase AM470_19300 ENOG4108ZRK uncharacterized protein yacC AM470_19305 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AM470_19310 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AM470_19315 ENOG4108ZIG UPF0231 protein AM470_19320 ENOG4107QIJ Aconitate hydratase 2 AM470_19325 ENOG4107QN2 dihydrolipoyl dehydrogenase AM470_19330 ENOG4107QSN dihydrolipoamide acetyltransferase AM470_19335 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AM470_19340 ENOG41073TP transcriptional regulator AM470_19345 ENOG4105C85 amino acid AM470_19350 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AM470_19360 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AM470_19370 ENOG4105XRQ Xanthine dehydrogenase accessory factor AM470_19375 ENOG4105UEI Transcriptional Regulator AraC Family AM470_19380 ENOG4107GFK fumarate AM470_19385 ENOG4105GPY SprT protein AM470_19390 ENOG4105RWS endonuclease I AM470_19395 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AM470_19400 ENOG4105D7Z glutathione synthase AM470_19405 ENOG4108UJU UPF0301 protein AM470_19410 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AM470_19415 ENOG4105CZX twitching motility protein AM470_19420 ENOG4105DFA alanine racemase domain protein AM470_19425 ENOG4105II7 pyrroline-5-carboxylate reductase AM470_19430 ENOG4108VIA integral membrane protein AM470_19435 ENOG4105VZ9 UPF0235 protein AM470_19445 ENOG4105CSA Coproporphyrinogen iii oxidase AM470_19455 ENOG4105K33 Periplasmic Protein AM470_19460 ENOG4105CSV Glutaminase AM470_19465 ENOG41090ED Protein with unknown function (DUF469) AM470_19470 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AM470_19475 ENOG4105CEN a g-specific adenine glycosylase AM470_19480 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AM470_19485 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AM470_19490 ENOG4105CXN decarboxylase AM470_19530 ENOG4105BZU Histidine kinase AM470_19610 ENOG4105CAU Arsenical resistance protein, ArsH AM470_19625 ENOG4105CHH sulfate transporter AM470_19640 ENOG4108M6U Universal stress protein A AM470_19645 ENOG4108M6U Universal stress protein A AM470_19685 ENOG4105CWB LysR family transcriptional Regulator AM470_19690 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) AM470_19695 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) AM470_19700 ENOG4105MWK D-amino acid dehydrogenase, small subunit AM470_19740 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR AM470_19745 ENOG4105UGQ Fimbrial AM470_19765 ENOG4108FZ9 Chaperone AM470_19770 ENOG4106PG1 outer membrane usher protein AM470_19820 ENOG4107RA9 decarboxylase AM470_19825 ENOG4105EMU Dehydrogenase AM470_19955 ENOG4108UUM single-stranded DNA-binding protein AM470_19965 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM470_20005 ENOG4105CDU Replicative dna helicase AM470_20030 ENOG4105UGQ Fimbrial AM470_20040 ENOG4108FZ9 Chaperone AM470_20050 ENOG4106PG1 outer membrane usher protein AM470_20080 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) AM470_20090 ENOG4105NIV Esterase AM470_20095 ENOG4105VEV -acetyltransferase AM470_20125 ENOG4105HSS phospholipase C AM470_20135 ENOG4105GAV receptor AM470_20140 ENOG4106KR7 LysR family Transcriptional regulator AM470_20145 ENOG4105CH2 amidohydrolase AM470_20150 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B AM470_20155 ENOG4105CFC Transporter AM470_20160 ENOG4105D7K pfkb domain protein AM470_20180 ENOG4105WBN Transcriptional regulator (LacI family AM470_20185 ENOG4108ZZF transport protein (ExbD) AM470_20190 ENOG4105CWK Biopolymer transport protein, ExbB AM470_20195 ENOG4105C28 cystathionine AM470_20200 ENOG4108K81 inner membrane protein YghB AM470_20205 ENOG4105CF7 AraC family transcriptional regulator AM470_20210 ENOG4108I6A alcohol dehydrogenase AM470_20215 ENOG4105CV8 reductase AM470_20220 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AM470_20240 ENOG4108TFM Kinase, PfkB family AM470_20245 ENOG4105EAA nucleoside AM470_20250 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AM470_20255 ENOG4105CN8 Transcriptional regulator AM470_20260 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) AM470_20265 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AM470_20270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM470_20275 ENOG4105NF4 modulator of drug activity AM470_20280 ENOG4105VRH Antibiotic biosynthesis monooxygenase AM470_20285 ENOG4105HEI LysR family (Transcriptional regulator AM470_20290 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM470_20295 ENOG4105IPS esterase AM470_20300 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AM470_20305 ENOG4108SX3 cytoplasmic protein AM470_20310 ENOG41087AY ADP-Ribose pyrophosphatase AM470_20315 ENOG4105DFG type I secretion outer membrane protein AM470_20325 ENOG4105VDH Dihydroxyacetone kinase AM470_20330 ENOG4108UTZ Dihydroxyacetone kinase AM470_20335 ENOG4105CMT Dihydroxyacetone kinase AM470_20345 ENOG4105F1G UPF0441 protein AM470_20350 ENOG4106032 Glutathionylspermidine synthase AM470_20355 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AM470_20365 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AM470_20370 ENOG4105W0Z cytoplasmic protein AM470_20375 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AM470_20380 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AM470_20385 ENOG4105I7R Adenylate cyclase AM470_20390 ENOG4106MWK domain protein AM470_20395 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AM470_20400 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AM470_20405 ENOG4107ZVW dihydroneopterin aldolase AM470_20410 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AM470_20415 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AM470_20420 ENOG4105VCC 30S ribosomal protein S21 AM470_20425 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AM470_20430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM470_20455 ENOG4108SHQ Glutathione S-transferase AM470_20465 ENOG4105C26 Dehydrogenase AM470_20470 ENOG4108JPW Aminotransferase AM470_20480 ENOG4105C5H ABC transporter AM470_20485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM470_20490 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AM470_20500 ENOG41081XE plasmid maintenance system antidote protein, xre family AM470_20505 ENOG4108VKG metal-dependent hydrolase AM470_20510 ENOG4105EE0 oxidoreductase AM470_20520 ENOG4105DU1 integral membrane protein, terc AM470_20525 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AM470_20530 ENOG4105CTX dehydratase AM470_20535 ENOG4105D2H Uronic isomerase AM470_20540 ENOG4105DPW Major facilitator superfamily MFS_1 AM470_20555 ENOG4106W5V Membrane AM470_20560 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) AM470_20570 ENOG4105NE1 Conserved Protein AM470_20575 ENOG41090KG Inner membrane protein YqjE AM470_20580 ENOG4105YJD AM470_20585 ENOG4108VBZ doxx family AM470_20590 ENOG4105CHF Glutathione S-transferase AM470_20595 ENOG4105CWB LysR family transcriptional Regulator AM470_20600 ENOG4108CNN domain protein AM470_20610 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AM470_20615 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) AM470_20620 ENOG41082RQ UPF0102 protein AM470_20625 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AM470_20630 ENOG4105W4M Transport-associated protein AM470_20640 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AM470_20645 ENOG4105BZU Histidine kinase AM470_20655 ENOG4105N5T Radical SAM Protein AM470_20665 ENOG4105CBC glutamate synthase AM470_20670 ENOG4105BZ8 glutamate synthase AM470_20680 ENOG4105KB2 stringent starvation protein b AM470_20685 ENOG4107MKT Stringent starvation protein a AM470_20690 ENOG4108UJD 30S ribosomal protein S9 AM470_20695 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AM470_20700 ENOG4105D6Z AFG1 family ATPase AM470_20705 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AM470_20710 ENOG4105C0H protease AM470_20715 ENOG4105C0H protease AM470_20720 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AM470_20725 ENOG4105VFK BolA family AM470_20730 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane AM470_20735 ENOG4105E3I toluene tolerance AM470_20740 ENOG4107PE3 Mammalian cell entry related domain protein AM470_20745 ENOG4105CY3 ABC transporter, permease AM470_20750 ENOG4105DHJ ABC, transporter AM470_20755 ENOG4105FEU K -dependent Na -Ca exchanger AM470_20760 ENOG4105C2X Arabinose 5-phosphate isomerase AM470_20765 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AM470_20770 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) AM470_20775 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AM470_20780 ENOG4108IUZ ABC transporter AM470_20785 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM470_20790 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AM470_20795 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AM470_20800 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AM470_20805 ENOG41080Z8 PHOSPHOCARRIER protein AM470_20810 ENOG4105EMD TRANSCRIPTIONal AM470_20830 ENOG41069H0 dihydroorotase EC 3.5.2.3 AM470_20860 ENOG4105NXH GreA GreB family elongation factor AM470_20870 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AM470_20880 ENOG4105R1U AraC Family Transcriptional Regulator AM470_20885 ENOG4108XVM Cytochrome b(562) AM470_20890 ENOG4105CMS peptidase U62, modulator of DNA gyrase AM470_20905 ENOG4105N42 UPF0307 protein AM470_20910 ENOG4105UNR (Barnase) inhibitor AM470_20920 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) AM470_20925 ENOG4105Y49 secretion protein, HlyD family AM470_20935 ENOG4105CR8 Transcriptional regulator AM470_20960 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) AM470_20965 ENOG4105D1U peptidase U62 modulator of DNA gyrase AM470_20975 ENOG4105QD6 exported protein AM470_20980 ENOG4105C03 ribonuclease AM470_20990 ENOG4105VQ7 Rod shape-determining protein MreD AM470_20995 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AM470_21000 ENOG4105DFF Rod shape-determining protein mreb AM470_21005 ENOG41062P1 Diguanylate cyclase phosphodiesterase AM470_21010 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AM470_21015 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AM470_21020 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AM470_21025 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AM470_21030 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AM470_21035 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AM470_21040 ENOG4105RG0 Membrane AM470_21045 ENOG4108IA2 Sodium pantothenate symporter AM470_21050 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AM470_21060 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AM470_21075 ENOG4105D1S lipid A biosynthesis AM470_21080 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AM470_21100 ENOG4105CMU LysR family (Transcriptional regulator AM470_21105 ENOG4105EEQ Na H antiporter AM470_21110 ENOG4105C7N Xanthine uracil vitamin C permease AM470_21120 ENOG4108RXX maleylacetoacetate isomerase AM470_21135 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AM470_21150 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AM470_21155 ENOG4105DQ4 alcohol dehydrogenase AM470_21160 ENOG4108UW5 maltose o-acetyltransferase AM470_21165 ENOG4105MSB protein, conserved in bacteria AM470_21170 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AM470_21175 ENOG4105CGF Aromatic amino acid aminotransferase AM470_21180 ENOG4108XM1 transcriptional regulator AsnC family AM470_21185 ENOG4105F87 Dehydratase AM470_21190 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AM470_21195 ENOG4105CDU Replicative dna helicase AM470_21200 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AM470_21205 ENOG4105P4Z Phage shock protein G AM470_21210 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AM470_21220 ENOG4105MYN Zinc uptake regulation protein AM470_21225 ENOG4105VDW Csbd family AM470_21230 ENOG4107R73 Mate efflux family protein AM470_21235 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AM470_21240 ENOG41080IJ Diacylglycerol kinase AM470_21245 ENOG4105E55 glycerol-3-phosphate acyltransferase AM470_21250 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AM470_21255 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AM470_21265 ENOG4105ETE Transcriptional regulator (LacI family AM470_21275 ENOG4107W52 maltose operon periplasmic protein AM470_21280 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) AM470_21295 ENOG4107FKK extracellular solute-binding protein family 1 AM470_21300 ENOG4105D56 permease protein AM470_21305 ENOG4105EG2 ABC transporter, permease AM470_21310 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AM470_21315 ENOG4108MRJ AM470_21320 ENOG4107QP8 phosphohexose isomerase AM470_21330 ENOG4105CFH Aspartokinase AM470_21335 ENOG4105C09 Bile acid AM470_21350 ENOG4105EAM Na Pi-cotransporter AM470_21355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_21380 ENOG4106S9K Transcriptional regulator AM470_21385 ENOG4105C3R Methionine synthase AM470_21390 ENOG41069M3 Transcriptional regulator AM470_21395 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AM470_21400 ENOG4105C6Z Gluconate AM470_21405 ENOG4105C01 Dihydroxy-acid dehydratase AM470_21410 ENOG4108UHU Aldolase AM470_21415 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AM470_21420 ENOG4108I9X Isocitrate lyase AM470_21425 ENOG4107QP3 malate synthase g AM470_21430 ENOG4105CVG Homoserine O-transsuccinylase AM470_21465 ENOG4108Z0R Transferase AM470_21470 ENOG4105E2X shikimate dehydrogenase AM470_21475 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AM470_21480 ENOG4108WI1 Dna topoisomerase AM470_21485 ENOG4108RPN Protein smg homolog AM470_21490 ENOG4105C79 DNA protecting protein DprA AM470_21495 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AM470_21500 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AM470_21505 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AM470_21510 ENOG4105C1A potassium transporter peripheral membrane AM470_21515 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AM470_21520 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AM470_21525 ENOG4105W1Y Transcriptional regulator AM470_21530 ENOG4105VTS DnaJ-like, subfamily C AM470_21535 ENOG4108ZT0 50S ribosomal protein l17 AM470_21540 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM470_21545 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AM470_21550 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AM470_21555 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AM470_21560 ENOG41067V7 50S ribosomal protein L36 AM470_21565 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AM470_21575 ENOG4105VPB 50S ribosomal protein L30 AM470_21580 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AM470_21585 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AM470_21590 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AM470_21595 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AM470_21610 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AM470_21615 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AM470_21620 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AM470_21630 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AM470_21635 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AM470_21645 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AM470_21655 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AM470_21660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AM470_21665 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AM470_21685 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AM470_21690 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AM470_21695 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AM470_21700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AM470_21705 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AM470_21710 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AM470_21715 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AM470_21720 ENOG4105WWK YheO domain protein AM470_21725 ENOG4108V1T peptidylprolyl cis-trans isomerase AM470_21730 ENOG4105VRX Protein slyX homolog AM470_21735 ENOG4105C87 Aminotransferase class I and II AM470_21740 ENOG4105DFD Na H antiporter AM470_21745 ENOG41060NJ transcriptional regulator AM470_21750 ENOG4108YZY peptidylprolyl cis-trans isomerase AM470_21755 ENOG4105VKU nucleicacid-binding protein AM470_21765 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AM470_21770 ENOG4105C5H ABC transporter AM470_21775 ENOG4105E2B Taurine dioxygenase AM470_21780 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AM470_21790 ENOG4106FTQ Taurine ABC transporter, periplasmic AM470_21795 ENOG4105JAB phenazine biosynthesis protein, phzf family AM470_21805 ENOG4105DNZ Alpha Beta Hydrolase AM470_21810 ENOG4105YP7 UPF0270 protein AM470_21815 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AM470_21820 ENOG4108UKZ OsmC family AM470_21825 ENOG4107RYR Transcriptional regulator, Crp Fnr family AM470_21830 ENOG410613R integral membrane protein, YccS YhfK family AM470_21835 ENOG4105C8Y Acetylornithine aminotransferase AM470_21845 ENOG4105D7A ATP-binding protein AM470_21860 ENOG4108NEV two component transcriptional regulator, LytTR family AM470_21865 ENOG4108HRK Histidine kinase AM470_21870 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AM470_21880 ENOG4105VCP PTS System AM470_21885 ENOG4105F8D glycoside hydrolase family 4 AM470_21890 ENOG41060NJ transcriptional regulator AM470_21895 ENOG4106DTQ Protein TsgA homolog AM470_21900 ENOG4105DZC cytosine deaminase AM470_21905 ENOG4107QZF nitrite reductase NADPH large subunit AM470_21910 ENOG4105WZK nitrite reductase NADPH small subunit AM470_21915 ENOG4107V9H nitrite transporter AM470_21920 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AM470_21925 ENOG4105C31 Tryptophanyl-tRNA synthetase AM470_21930 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AM470_21950 ENOG4105D49 3-dehydroquinate synthase AM470_21955 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AM470_21960 ENOG4105E4G Type IV pilus AM470_21985 ENOG4108JQC penicillin-binding protein 1A AM470_21990 ENOG4107RK2 ADP-ribose diphosphatase NudE AM470_21995 ENOG4105DQY intracellular growth attenuator AM470_22000 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AM470_22005 ENOG4105VEJ Heat shock protein AM470_22010 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AM470_22030 ENOG4105E0F Histidine kinase AM470_22035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AM470_22040 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) AM470_22045 ENOG4105DVC DnaJ domain protein AM470_22050 ENOG4108RRZ Transcription elongation factor GreB AM470_22055 ENOG4105BZM domain protein AM470_22060 ENOG4105XFK Ferrous iron transport protein A AM470_22070 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) AM470_22085 ENOG4105MJ2 Competence protein AM470_22090 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AM470_22095 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AM470_22100 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AM470_22105 ENOG41061ZR Transcriptional regulator AM470_22130 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport AM470_22150 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AM470_22155 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AM470_22160 ENOG4105E98 transcriptional regulator DeoR family AM470_22165 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AM470_22170 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AM470_22175 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AM470_22180 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AM470_22185 ENOG4108ESZ Glycogen debranching enzyme AM470_22190 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AM470_22195 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM470_22200 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AM470_22205 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AM470_22210 ENOG4105C6Z Gluconate AM470_22215 ENOG4105DIQ Transcriptional regulator AM470_22220 ENOG4105C2I pirin domain protein AM470_22225 ENOG4105WCN acetyltransferase AM470_22230 ENOG4105KXX peptidase s58 dmpa AM470_22235 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AM470_22240 ENOG4105F0H myo-inositol catabolism protein AM470_22245 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AM470_22250 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AM470_22255 ENOG4105EDK PfkB domain protein AM470_22275 ENOG4105DH8 myo-inositol catabolism AM470_22280 ENOG4105C26 Dehydrogenase AM470_22285 ENOG4107QNK )-transporter AM470_22295 ENOG4105C4B ABC transporter, permease AM470_22300 ENOG41083J0 (ABC) transporter AM470_22320 ENOG4106PG1 outer membrane usher protein AM470_22325 ENOG4106P2F Pfam:Pili_assembly_C AM470_22345 ENOG4108N8T regulatoR AM470_22355 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AM470_22380 ENOG4105C0W non-ribosomal peptide synthetase AM470_22395 ENOG4105T38 integral membrane protein AM470_22415 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AM470_22420 ENOG4105CBX hi0933 family AM470_22425 ENOG4105CJ3 phosphate transporter AM470_22445 ENOG4105CKD glutathione-regulated potassium-efflux system protein AM470_22455 ENOG4105CBN LysR family transcriptional regulator AM470_22460 ENOG4108M6U Universal stress protein A AM470_22475 ENOG4105C2J ABC transporter AM470_22480 ENOG4105CNN ABC, transporter AM470_22485 ENOG4105CNN ABC, transporter AM470_22495 ENOG4105C2X Arabinose 5-phosphate isomerase AM470_22500 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AM470_22505 ENOG4105DGW oligopeptidase A AM470_22530 ENOG4105D6S protein involved in catabolism of external DNA AM470_22535 ENOG4105DC8 reductase AM470_22545 ENOG4105BZU Histidine kinase AM470_22570 ENOG4105EQN UPF0261 protein AM470_22575 ENOG4108SPG Periplasmic Protein AM470_22580 ENOG4105BZU Histidine kinase AM470_22585 ENOG4105E39 Enoyl-CoA hydratase AM470_22590 ENOG4107H3J ribonuclease AM470_22595 ENOG4105CSH Transporter AM470_22600 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) AM470_22605 ENOG41066T0 asmA family AM470_22610 ENOG4105CMB EAL domain-containing protein AM470_22615 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AM470_22625 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AM470_22630 ENOG4105EMY transcriptional regulator AM470_22650 ENOG4105C7B Threonine dehydratase AM470_22655 ENOG4105C01 Dihydroxy-acid dehydratase AM470_22660 ENOG4105CM2 brancheD-chain amino acid aminotransferase AM470_22665 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AM470_22680 ENOG4107RGD Major Facilitator superfamily AM470_22685 ENOG4105C0P Mg chelatase subunit ChlI AM470_22690 ENOG4108WFC UPF0438 protein yifE AM470_22695 ENOG4105CVI Transcriptional regulator AM470_22735 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AM470_22740 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AM470_22745 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) AM470_22750 ENOG4108Y73 Membrane AM470_22760 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AM470_22765 ENOG4105C5Q Transcriptional regulator AM470_22770 ENOG4105EHV domain protein AM470_22775 ENOG4107QN2 dihydrolipoyl dehydrogenase AM470_22785 ENOG4105CH7 arginosuccinase AM470_22790 ENOG4105CDH Citrulline--aspartate ligase AM470_22795 ENOG4105CAS nag kinase AM470_22800 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AM470_22810 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AM470_22815 ENOG4105SYT Methylenetetrahydrofolate reductase AM470_22820 ENOG4105CFH Aspartokinase AM470_22825 ENOG4105C28 cystathionine AM470_22830 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AM470_22835 ENOG4105VFB Binds the 23S rRNA (By similarity) AM470_22840 ENOG4105C25 Primosomal protein n' AM470_22845 ENOG4105ETE Transcriptional regulator (LacI family AM470_22850 ENOG41063M6 Cell Division Protein AM470_22855 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AM470_22860 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AM470_22865 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AM470_22870 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) AM470_22875 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AM470_22880 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM470_22890 ENOG4105CBT Fructose-1,6-bisphosphatase AM470_22895 ENOG4105E5M Multidrug resistance protein D AM470_22905 ENOG4105DP0 ferredoxin-NADP reductase AM470_22910 ENOG4108VTS Membrane AM470_22915 ENOG4105EBK exported protein AM470_22920 ENOG4105CP7 Triose-phosphate isomerase AM470_22925 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AM470_22930 ENOG4105CTQ phosphohexokinase AM470_22935 ENOG41076HS cation diffusion facilitator family transporter AM470_22940 ENOG4105FMW periplasmic AM470_22945 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM470_22950 ENOG4105E0F Histidine kinase AM470_22955 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AM470_22965 ENOG4108KKZ (LipO)protein AM470_22970 ENOG4105D7W serine acetyltransferase AM470_22985 ENOG4105VW4 glutaredoxin 3 AM470_22990 ENOG4107YZP Rhodanese domain protein AM470_22995 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AM470_23000 ENOG41063SB peptidase AM470_23005 ENOG4105PXI polysaccharide deacetylase AM470_23010 ENOG4105CPQ Dehydrogenase AM470_23015 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM470_23020 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AM470_23025 ENOG4105XA0 heptosyltransferase ii AM470_23030 ENOG4105D16 lipopolysaccharide heptosyltransferase i AM470_23035 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) AM470_23040 ENOG41068PG O-Antigen polymerase AM470_23060 ENOG4105DKP glycosyl transferase, family 9 AM470_23065 ENOG4107RJ7 Glycosyl transferase (Group 1 AM470_23070 ENOG4105CPK Glycosyl transferase (Group 1 AM470_23080 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AM470_23100 ENOG4105W0E 50S ribosomal protein L33 AM470_23105 ENOG4105KDC 50s ribosomal protein l28 AM470_23110 ENOG4105W5Q DNA repair protein (RadC AM470_23115 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AM470_23120 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AM470_23125 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AM470_23130 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AM470_23135 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AM470_23140 ENOG4105DSJ YicC domain protein AM470_23195 ENOG4105ZTC transcriptional activator, Ogr delta AM470_23205 ENOG4105DZG Dehydrogenase AM470_23215 ENOG4108JGH Tetr family transcriptional regulator AM470_23220 ENOG4105F1S paraquat-inducible protein a AM470_23225 ENOG4105DY2 Paraquat-inducible protein b AM470_23230 ENOG4108Q2G (LipO)protein AM470_23240 ENOG4105CR8 Transcriptional regulator AM470_23245 ENOG4105CHU acetyl-coa acetyltransferase AM470_23250 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr AM470_23255 ENOG4105CEY Amp-dependent synthetase and ligase AM470_23270 ENOG4105D9N nucleoside AM470_23280 ENOG4105EN6 Membrane AM470_23285 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AM470_23290 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AM470_23295 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AM470_23300 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AM470_23305 ENOG4105CB5 ATP-dependent DNA helicase recG AM470_23310 ENOG4105D6U Sodium Glutamate Symporter AM470_23315 ENOG4105C2W permease AM470_23320 ENOG4105JV1 AsmA family AM470_23325 ENOG4105SUU thioesterase domain AM470_23330 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AM470_23335 ENOG4107S2Z UPF0761 membrane protein AM470_23340 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 AM470_23350 ENOG4105C5F glutamine synthetase AM470_23355 ENOG4105CUX Signal transduction histidine kinase AM470_23360 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM470_23365 ENOG4105D4P Coproporphyrinogen iii oxidase AM470_23375 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) AM470_23385 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AM470_23390 ENOG4105C2M dna polymerase I AM470_23395 ENOG4106HNH Acyl-transferase AM470_23400 ENOG4108Z33 Thiol disulfide Interchange Protein AM470_23405 ENOG4105E27 serine threonine protein kinase AM470_23410 ENOG4105PC1 Conserved Protein AM470_23415 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AM470_23420 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AM470_23445 ENOG4107EJG GntR family transcriptional regulator AM470_23450 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM470_23455 ENOG4105ETE Transcriptional regulator (LacI family AM470_23460 ENOG4108RVA ribokinase AM470_23465 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM470_23470 ENOG4105CNN ABC, transporter AM470_23475 ENOG4105C2J ABC transporter AM470_23480 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AM470_23490 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) AM470_23495 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AM470_23500 ENOG4105CU9 asparagine synthetase A AM470_23505 ENOG4108VVK transcriptional Regulator, AsnC AM470_23510 ENOG4105QTB Flavodoxin AM470_23515 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AM470_23520 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AM470_23525 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation AM470_23530 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AM470_23535 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AM470_23540 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AM470_23545 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AM470_23550 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AM470_23555 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AM470_23560 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AM470_23565 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AM470_23570 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AM470_23575 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AM470_23580 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AM470_23585 ENOG4105C8U phosphate abc transporter AM470_23590 ENOG4105E2Z phosphate ABC transporter (Permease AM470_23605 ENOG4106PMH Extracellular solute-binding protein family 3 AM470_23610 ENOG4105EAD ABC transporter AM470_23620 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AM470_23625 ENOG4105M6F mutator MutT protein AM470_23630 ENOG4105C7N Xanthine uracil vitamin C permease AM470_23640 ENOG4108YYH Nadph-dependent fmn reductase AM470_23645 ENOG4107YAK holo-(acyl carrier protein) synthase 2 AM470_23650 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) AM470_23655 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AM470_23660 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AM470_23665 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AM470_23670 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AM470_23680 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AM470_23685 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AM470_23690 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AM470_23695 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM470_23700 ENOG410667J hydrolase AM470_23710 ENOG4105C7B Threonine dehydratase AM470_23720 ENOG4105D99 atp gtp-binding protein AM470_23725 ENOG4105R2A (LipO)protein AM470_23730 ENOG4108ZNX Heat shock protein AM470_23735 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) AM470_23740 ENOG4105D0C transport protein AM470_23750 ENOG41068KX affects formate dehydrogenase-N AM470_23755 ENOG4105JKW Valine--pyruvate aminotransferase AM470_23760 ENOG4107T9C Alpha amylase catalytic region AM470_23765 ENOG4105C5I Dehydrogenase AM470_23770 ENOG4105JHE Major Facilitator Superfamily AM470_23775 ENOG4105D7K pfkb domain protein AM470_23785 ENOG4108M60 Transcriptional regulator AM470_23790 ENOG4108ZG0 Ompa motb domain protein AM470_23800 ENOG4108R3E Dna-3-methyladenine glycosylase i AM470_23810 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit AM470_23815 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AM470_23820 ENOG4106JH6 (LipO)protein AM470_23825 ENOG4105CTS PTS system mannitol-specific AM470_23830 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AM470_23835 ENOG4105E61 Mannitol repressor protein AM470_23845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM470_23850 ENOG4108YYI Protein of unknown function (DUF2810) AM470_23860 ENOG4108RPX mosc domain containing protein AM470_23865 ENOG4105C8Q Methyl-accepting chemotaxis AM470_23870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM470_23875 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AM470_23880 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AM470_23885 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM470_23890 ENOG4108MG3 formate dehydrogenase AM470_23895 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AM470_23905 ENOG4108U78 Glutathione S-transferase AM470_23910 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AM470_23915 ENOG4105EM7 Selenocysteine-specific translation elongation factor AM470_23945 ENOG4105MEV Acyl-transferase AM470_23955 ENOG4108RWI nicotinamidase AM470_23960 ENOG4105DZC cytosine deaminase AM470_23975 ENOG4107NQ8 LysR family Transcriptional regulator AM470_23980 ENOG4105DJ2 Major Facilitator Superfamily AM470_24015 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM470_24035 ENOG4105F27 Major Facilitator AM470_24055 ENOG4105TW1 Carbohydrate-selective porin OprB AM470_24065 ENOG4105K56 Transcriptional regulator AM470_24070 ENOG4108ZHJ Organic hydroperoxide resistance protein AM470_24075 ENOG4105DIJ Phosphoethanolamine transferase AM470_24080 ENOG4108KX4 response regulator AM470_24085 ENOG4105BZU Histidine kinase AM470_24090 ENOG4105CXY transporter AM470_24110 ENOG4105DEF Extracellular solute-binding protein, family 5 AM470_24115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM470_24120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM470_24125 ENOG4105C3U ABC transporter AM470_24130 ENOG4108JQ7 (ABC) transporter AM470_24135 ENOG4105D1V cellulose synthase operon protein YhjU AM470_24140 ENOG4105WQA Cellulose biosynthesis protein BcsF AM470_24145 ENOG4105U74 cellulose biosynthesis protein BcsE AM470_24160 ENOG4107QZ7 Cellulose synthase catalytic subunit AM470_24165 ENOG4107EEX Cellulose synthase regulator protein AM470_24170 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) AM470_24175 ENOG4105EJG cellulose synthase AM470_24180 ENOG4105BZU Histidine kinase AM470_24185 ENOG4105CK2 sodium dicarboxylate symporter AM470_24190 ENOG4105CS0 peptidase AM470_24195 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AM470_24200 ENOG4105C4R Atp-dependent dna helicase AM470_24205 ENOG4105C9X ppx gppa phosphatase AM470_24210 ENOG4105C1J atp-dependent rna helicase AM470_24215 ENOG4105K63 Thioredoxin AM470_24225 ENOG4105ESV Glycosyl transferase, family 4 AM470_24230 ENOG4105SFE lipopolysaccharide biosynthesis protein AM470_24235 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AM470_24240 ENOG4108IJ1 Dehydrogenase AM470_24245 ENOG4105C1B dTDP-glucose 4-6-dehydratase AM470_24250 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AM470_24255 ENOG4108WJ1 acetyltransferase AM470_24260 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AM470_24265 ENOG4105EGZ biosynthesis protein AM470_24270 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) AM470_24275 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) AM470_24280 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AM470_24285 ENOG4105C85 amino acid AM470_24310 ENOG410601J HemY protein AM470_24315 ENOG4105ECF c-methyltransferase AM470_24320 ENOG41076E6 Uroporphyrinogen-III Synthase AM470_24325 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AM470_24335 ENOG4105XQ6 frataxin-like protein AM470_24340 ENOG4105S7Z (LipO)protein AM470_24345 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AM470_24350 ENOG4105CT0 Protein of unknown function, DUF484 AM470_24360 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AM470_24365 ENOG4105C4R Atp-dependent dna helicase AM470_24380 ENOG4107QUT magnesium and cobalt transport protein CorA AM470_24385 ENOG4105FR1 rard protein AM470_24390 ENOG4108VUY thioesterase Superfamily protein AM470_24395 ENOG4105HDD phospholipase AM470_24400 ENOG4105C9U ATP-dependent DNA helicase RecQ AM470_24415 ENOG4108EUD Lysophospholipase AM470_24420 ENOG4105DQF Hydrolase AM470_24425 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AM470_24430 ENOG4105CXY transporter AM470_24440 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AM470_24450 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AM470_24455 ENOG4108W1V Lipoprotein AM470_24465 ENOG4105EX9 Membrane AM470_24470 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AM470_24475 ENOG4105C59 p-type ATPase AM470_24490 ENOG4107FS9 Membrane AM470_24500 ENOG4105MG3 Membrane AM470_24505 ENOG4106H78 methyltransferase AM470_24510 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AM470_24510 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AM470_24515 ENOG4105CAK Cell division ATP-binding protein ftsE AM470_24520 ENOG4105CRP Part of the ABC transporter FtsEX involved in AM470_24540 ENOG4105U59 -acetyltransferase AM470_24550 ENOG4105C32 Amino acid ABC transporter (Permease) AM470_24555 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM470_24560 ENOG4105C0Z ABC transporter AM470_24565 ENOG4108IV0 ABC, transporter AM470_24570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM470_24575 ENOG4105BZ7 extracellular solute-binding protein family 1 AM470_24580 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AM470_24590 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM470_24595 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AM470_24610 ENOG4105EMK carboxylate amino acid amine transporter AM470_24615 ENOG4105DZ2 Transcriptional regulator AM470_24620 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AM470_24625 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AM470_24630 ENOG4108I5U Uridine phosphorylase AM470_24640 ENOG4108KF1 Membrane AM470_24645 ENOG4105CGY Dna recombination protein AM470_24650 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AM470_24655 ENOG4105JC1 sterol-binding domain protein AM470_24660 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AM470_24665 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AM470_24675 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AM470_24680 ENOG4105F8V Hydrolase, tatD family AM470_24685 ENOG4105D52 delta-aminolevulinic acid dehydratase AM470_24690 ENOG4105MDZ Transcriptional activator rfaH AM470_24695 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) AM470_24705 ENOG4107QK7 reductase AM470_24710 ENOG4105CHU acetyl-coa acetyltransferase AM470_24715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM470_24720 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) AM470_24725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AM470_24730 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AM470_24735 ENOG4108RR8 protoporphyrinogen oxidase AM470_24760 ENOG4105D4A Cell wall formation (By similarity) AM470_24765 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AM470_24770 ENOG4105CS9 pantothenic acid kinase AM470_24805 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AM470_24810 ENOG4105PM1 preprotein translocase subunit SecE AM470_24815 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AM470_24830 ENOG4108VZM 50s ribosomal protein L10 AM470_24840 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM470_24845 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM470_24860 ENOG4105US7 Histidine kinase AM470_24875 ENOG4105D41 biosynthesis protein thiH AM470_24880 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AM470_24885 ENOG4105WHD thiamine biosynthesis protein ThiS AM470_24890 ENOG4105D06 uba thif-type nad fad binding protein AM470_24895 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AM470_24900 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AM470_24905 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor AM470_24910 ENOG4105E09 nadh pyrophosphatase AM470_24915 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AM470_24920 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) AM470_24925 ENOG4105R2J Conserved Protein AM470_24935 ENOG4108T8B Protein of unknown function (DUF1481) AM470_24940 ENOG4105C12 Phosphoribosylglycinamide synthetase AM470_24945 ENOG4105DC1 bifunctional purine biosynthesis protein purh AM470_24975 ENOG4107QN1 sodium solute AM470_24980 ENOG41062QD Membrane AM470_24985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AM470_24990 ENOG4105CK2 sodium dicarboxylate symporter AM470_24995 ENOG4105C0W non-ribosomal peptide synthetase AM470_25000 ENOG4105C0W non-ribosomal peptide synthetase AM470_25005 ENOG4105C0W non-ribosomal peptide synthetase AM470_25010 ENOG4107RBR Receptor AM470_25015 ENOG4105CEY Amp-dependent synthetase and ligase AM470_25020 ENOG4108NS2 receptor AM470_25025 ENOG4107RNH Outer membrane receptor FepA AM470_25030 ENOG4105E93 esterase AM470_25040 ENOG4105C0W non-ribosomal peptide synthetase AM470_25050 ENOG4105E4F Isochorismate synthase AM470_25055 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AM470_25060 ENOG4105WQI isochorismatase AM470_25065 ENOG4108NS2 receptor AM470_25070 ENOG4108R5S membrane AM470_25085 ENOG4108SIC Transcriptional regulator AM470_25090 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AM470_25100 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AM470_25115 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AM470_25125 ENOG4108ZVF (LipO)protein AM470_25130 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AM470_25135 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AM470_25140 ENOG4106HKS Entericidin EcnA/B family AM470_25145 ENOG4106BSU Entericidin B AM470_25160 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AM470_25165 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AM470_25180 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AM470_25185 ENOG4105EGS Mechanosensitive ion channel AM470_25190 ENOG4105DJ4 phosphatidylserine decarboxylase AM470_25195 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AM470_25200 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) AM470_25220 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AM470_25225 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AM470_25230 ENOG4105K8N protein family UPF0079, ATPase AM470_25235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AM470_25240 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AM470_25245 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AM470_25250 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AM470_25255 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AM470_25260 ENOG4107QJR hflk protein AM470_25265 ENOG4105EPW hflc protein AM470_25275 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AM470_25280 ENOG4105KPV Transcriptional regulator AM470_25285 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AM470_25290 ENOG4105C2N RNA methyltransferase TrmH family group 3 AM470_25295 ENOG4105CSU acyl-Coa dehydrogenase AM470_25300 ENOG4105Z6B inner membrane protein yjfl AM470_25310 ENOG4105WSB biofilm stress and motility protein A AM470_25315 ENOG4108MXZ Esterase AM470_25330 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AM470_25340 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AM470_25345 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AM470_25355 ENOG4105FHY Opacity-associated protein A AM470_25360 ENOG4108V1T peptidylprolyl cis-trans isomerase AM470_25370 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AM470_25375 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AM470_25380 ENOG4108UUE Transcriptional regulator AM470_25385 ENOG41061GZ Protein of unknown function (DUF1107) AM470_25390 ENOG4105C37 (CBS) domain AM470_25395 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AM470_25400 ENOG4105CFU surface antigen