locus-tag	class	description
AM378_00005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM378_00010	COG1555	photosystem II stabilization
AM378_00015	COG0824	Thioesterase
AM378_00020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM378_00025	COG4533	DNA binding
AM378_00030	COG0561	phosphatase activity
AM378_00040	COG1522	sequence-specific DNA binding
AM378_00045	COG1132	(ABC) transporter
AM378_00050	COG1132	(ABC) transporter
AM378_00055	COG0347	Belongs to the P(II) protein family
AM378_00060	COG0004	ammonium transporteR
AM378_00065	COG1946	Acyl-CoA thioesterase
AM378_00070	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AM378_00075	COG3695	enzyme binding
AM378_00110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM378_00165	COG3397	chitin binding
AM378_00190	COG1121	(ABC) transporter
AM378_00195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM378_00200	COG0803	Belongs to the bacterial solute-binding protein 9 family
AM378_00205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM378_00210	COG0254	rRNA binding
AM378_00215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_00220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_00225	COG1309	transcriptional regulator
AM378_00230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM378_00245	COG2832	Protein of unknown function (DUF454)
AM378_00250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AM378_00255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AM378_00265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM378_00270	COG0326	Molecular chaperone. Has ATPase activity
AM378_00280	COG0563	adenylate kinase activity
AM378_00285	COG3835	regulator
AM378_00290	COG2610	gluconate transmembrane transporter activity
AM378_00295	COG1929	Belongs to the glycerate kinase type-1 family
AM378_00300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM378_00305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_00310	COG4651	solute:proton antiporter activity
AM378_00310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM378_00315	COG2223	nitrite transmembrane transporter activity
AM378_00320	COG0737	Belongs to the 5'-nucleotidase family
AM378_00330	COG2814	Major facilitator Superfamily
AM378_00340	COG3483	tryptophan 2,3-dioxygenase activity
AM378_00365	COG2027	D-alanyl-D-alanine carboxypeptidase
AM378_00370	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM378_00375	COG3735	TraB family
AM378_00380	COG2217	Heavy metal translocating P-type atpase
AM378_00385	COG0789	Transcriptional regulator
AM378_00390	COG1585	Membrane protein implicated in regulation of membrane protease activity
AM378_00395	COG0330	HflC and HflK could
AM378_00400	COG0583	DNA-binding transcription factor activity
AM378_00410	COG1414	Transcriptional regulator
AM378_00415	COG3960	tartronate-semialdehyde synthase activity
AM378_00420	COG3622	Belongs to the hyi family
AM378_00425	COG2084	Dehydrogenase
AM378_00430	COG2271	Major facilitator Superfamily
AM378_00435	COG1929	Belongs to the glycerate kinase type-1 family
AM378_00440	COG3257	ureidoglycine aminohydrolase activity
AM378_00450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM378_00455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AM378_00460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM378_00465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM378_00475	COG0549	Belongs to the carbamate kinase family
AM378_00480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM378_00485	COG3118	belongs to the thioredoxin family
AM378_00490	COG0300	oxidoreductase activity
AM378_00495	COG2755	lipolytic protein G-D-S-L family
AM378_00500	COG4181	ATPase activity
AM378_00505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AM378_00510	COG2814	Major facilitator Superfamily
AM378_00515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM378_00520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM378_00525	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM378_00530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM378_00535	COG0215	cysteine-tRNA ligase activity
AM378_00540	COG2501	S4 domain
AM378_00545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AM378_00575	COG2199	diguanylate cyclase activity
AM378_00580	COG1278	Cold shock
AM378_00590	COG1126	abc transporter atp-binding protein
AM378_00595	COG0765	amino acid transport
AM378_00610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM378_00620	COG1278	Cold shock
AM378_00625	COG2814	Major facilitator Superfamily
AM378_00630	COG1309	transcriptional regulator
AM378_00635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AM378_00640	COG3706	GGDEF domain
AM378_00650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM378_00655	COG0321	lipoyl(octanoyl) transferase activity
AM378_00665	COG1686	Belongs to the peptidase S11 family
AM378_00670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM378_00675	COG0772	Belongs to the SEDS family
AM378_00680	COG0768	penicillin binding
AM378_00685	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AM378_00690	COG0799	negative regulation of ribosome biogenesis
AM378_00695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AM378_00700	COG1466	dna polymerase III delta subunit
AM378_00705	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AM378_00710	COG0495	leucyl-tRNA aminoacylation
AM378_00715	COG2888	peptidyl-tyrosine sulfation
AM378_00725	COG1957	nucleoside hydrolase
AM378_00735	COG1126	abc transporter atp-binding protein
AM378_00740	COG0765	amino acid transport
AM378_00745	COG0765	amino acid transport
AM378_00755	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AM378_00760	COG4535	Mg2 and Co2 transporter CorC
AM378_00765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM378_00770	COG1702	phosphate starvation-inducible protein PhoH
AM378_00775	COG2824	Alkylphosphonate utilization operon protein PhnA
AM378_00780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM378_00785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM378_00820	COG0367	asparagine synthase
AM378_00825	COG3469	chitinase activity
AM378_00830	COG0647	UMP catabolic process
AM378_00835	COG1846	Transcriptional regulator
AM378_00835	COG1940	carbohydrate kinase activity
AM378_00840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AM378_00845	COG0363	glucosamine-6-phosphate deaminase activity
AM378_00850	COG2190	(PTS) system
AM378_00850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_00850	COG1263	PTS System
AM378_00855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM378_00875	COG0735	belongs to the Fur family
AM378_00890	COG0596	Alpha beta hydrolase
AM378_00895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AM378_00900	COG0033	Phosphoglucomutase
AM378_00905	COG1695	Transcriptional regulator
AM378_00915	COG0745	RESPONSE REGULATOR receiver
AM378_00920	COG2205	protein histidine kinase activity
AM378_00925	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AM378_00930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AM378_00935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AM378_00950	COG3272	Protein of unknown function (DUF1722)
AM378_00960	COG5212	phosphodiesterase
AM378_00965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM378_00970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AM378_00975	COG1984	allophanate hydrolase subunit 2
AM378_00980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AM378_01010	COG2009	succinate dehydrogenase
AM378_01015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM378_01020	COG1053	succinate dehydrogenase
AM378_01025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM378_01030	COG0567	Dehydrogenase, E1 component
AM378_01035	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM378_01040	COG0045	succinate-CoA ligase (ADP-forming) activity
AM378_01045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AM378_01050	COG0737	Belongs to the 5'-nucleotidase family
AM378_01055	COG1271	oxidase subunit
AM378_01060	COG1294	oxidase, subunit
AM378_01065	COG4890	Cyd operon protein YbgT
AM378_01070	COG3790	cyd operon protein YbgE
AM378_01075	COG0824	Thioesterase
AM378_01080	COG0811	peptide transport
AM378_01085	COG0848	biopolymer transport protein
AM378_01090	COG3064	Membrane
AM378_01090	COG3064	Membrane
AM378_01095	COG0823	Involved in the tonB-independent uptake of proteins
AM378_01100	COG2885	chlorophyll binding
AM378_01105	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AM378_01155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM378_01165	COG1230	cation diffusion facilitator family transporter
AM378_01170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_01170	COG2205	protein histidine kinase activity
AM378_01175	COG2197	response regulator
AM378_01180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM378_01195	COG0588	phosphoglycerate mutase activity
AM378_01205	COG2017	converts alpha-aldose to the beta-anomer
AM378_01210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AM378_01230	COG1119	ATPase activity
AM378_01235	COG2005	Transcriptional regulator
AM378_01235	COG3585	molybdate ion transport
AM378_01240	COG4774	siderophore transport
AM378_01250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AM378_01255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_01260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AM378_01270	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM378_01275	COG4149	molybdate abc transporter
AM378_01285	COG0561	phosphatase activity
AM378_01290	COG2706	6-phosphogluconolactonase activity
AM378_01295	COG1881	PFAM PEBP family protein
AM378_01335	COG0556	nucleotide-excision repair
AM378_01340	COG4628	conserved protein (DUF2132)
AM378_01345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AM378_01350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM378_01355	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM378_01360	COG0315	cyclic pyranopterin monophosphate synthase activity
AM378_01365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AM378_01370	COG0314	molybdopterin synthase activity
AM378_01375	COG0670	Belongs to the BI1 family
AM378_01380	COG0842	Transport permease protein
AM378_01385	COG0842	Transport permease protein
AM378_01390	COG1131	(ABC) transporter
AM378_01395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_01400	COG1309	transcriptional regulator
AM378_01405	COG0513	Belongs to the DEAD box helicase family
AM378_01410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM378_01415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM378_01425	COG3842	ATPase activity
AM378_01435	COG1840	ABC-type Fe3 transport system, periplasmic component
AM378_01440	COG2271	Major facilitator Superfamily
AM378_01460	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_01465	COG0583	DNA-binding transcription factor activity
AM378_01485	COG0583	DNA-binding transcription factor activity
AM378_01490	COG0586	Pfam SNARE associated Golgi protein
AM378_01500	COG4977	sequence-specific DNA binding
AM378_01505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM378_01510	COG1686	Belongs to the peptidase S11 family
AM378_01530	COG2354	Protein conserved in bacteria
AM378_01540	COG1464	Belongs to the NlpA lipoprotein family
AM378_01550	COG0456	acetyltransferase
AM378_01570	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AM378_01580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_01585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AM378_01590	COG0840	transmembrane signaling receptor activity
AM378_01595	COG0277	FAD linked oxidase domain protein
AM378_01600	COG0024	Methionine aminopeptidase
AM378_01610	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM378_01620	COG0436	Aminotransferase
AM378_01630	COG1472	Belongs to the glycosyl hydrolase 3 family
AM378_01670	COG0596	Alpha beta hydrolase
AM378_01675	COG2134	cdp-diacylglycerol pyrophosphatase
AM378_01705	COG1192	Involved in chromosome partitioning
AM378_01710	COG1403	HNH endonuclease
AM378_01715	COG0583	DNA-binding transcription factor activity
AM378_01725	COG1070	Carbohydrate kinase
AM378_01730	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM378_01735	COG0697	spore germination
AM378_01745	COG2207	Transcriptional regulator
AM378_01790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AM378_01805	COG1309	transcriptional regulator
AM378_01810	COG1464	Belongs to the NlpA lipoprotein family
AM378_01815	COG2011	ABC-type metal ion transport system permease component
AM378_01820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM378_01825	COG0519	Catalyzes the synthesis of GMP from XMP
AM378_01845	COG2084	Dehydrogenase
AM378_01860	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AM378_01875	COG4807	Protein conserved in bacteria
AM378_01895	COG1802	Transcriptional regulator
AM378_01905	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM378_01915	COG0411	ABC transporter
AM378_01955	COG0583	DNA-binding transcription factor activity
AM378_01960	COG2897	thiosulfate sulfurtransferase activity
AM378_01965	COG0494	nUDIX hydrolase
AM378_01970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM378_01980	COG0625	glutathione transferase activity
AM378_01990	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AM378_02000	COG1335	isochorismatase
AM378_02005	COG0583	DNA-binding transcription factor activity
AM378_02020	COG1732	Glycine betaine
AM378_02025	COG1174	glycine betaine transport
AM378_02030	COG1125	glycine betaine transport
AM378_02035	COG1174	glycine betaine transport
AM378_02055	COG0697	spore germination
AM378_02090	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AM378_02105	COG0625	glutathione transferase activity
AM378_02110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM378_02115	COG1942	4-Oxalocrotonate Tautomerase
AM378_02125	COG1522	sequence-specific DNA binding
AM378_02130	COG0697	spore germination
AM378_02150	COG2079	MmgE PrpD family protein
AM378_02155	COG1280	lysine exporter protein (LysE YggA)
AM378_02165	COG0477	Major facilitator Superfamily
AM378_02175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM378_02195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM378_02200	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AM378_02215	COG0668	transmembrane transport
AM378_02220	COG1126	abc transporter atp-binding protein
AM378_02225	COG0765	amino acid transport
AM378_02230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_02235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM378_02250	COG2731	YhcH YjgK YiaL family protein
AM378_02260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM378_02265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM378_02280	COG2610	gluconate transmembrane transporter activity
AM378_02285	COG3622	Belongs to the hyi family
AM378_02290	COG0235	Class ii aldolase
AM378_02295	COG3395	kinase activity
AM378_02300	COG2084	Dehydrogenase
AM378_02305	COG1349	DNA-binding transcription factor activity
AM378_02315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM378_02320	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AM378_02360	COG3188	usher protein
AM378_02375	COG5002	protein histidine kinase activity
AM378_02380	COG0745	RESPONSE REGULATOR receiver
AM378_02385	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AM378_02390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM378_02405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM378_02410	COG1309	transcriptional regulator
AM378_02415	COG1012	belongs to the aldehyde dehydrogenase family
AM378_02420	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AM378_02425	COG0069	glutamate synthase activity
AM378_02435	COG2200	EAL domain
AM378_02445	COG3121	Chaperone
AM378_02450	COG3188	usher protein
AM378_02460	COG3708	Transcriptional regulator
AM378_02460	COG2207	Transcriptional regulator
AM378_02465	COG0579	oxidoreductase
AM378_02475	COG0625	glutathione transferase activity
AM378_02480	COG0640	Transcriptional regulator
AM378_02490	COG1335	isochorismatase
AM378_02495	COG0583	DNA-binding transcription factor activity
AM378_02510	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AM378_02520	COG0583	DNA-binding transcription factor activity
AM378_02530	COG0488	(ABC) transporter
AM378_02535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM378_02540	COG0303	'Molybdopterin
AM378_02555	COG4172	Belongs to the ABC transporter superfamily
AM378_02560	COG0747	negative chemotaxis
AM378_02565	COG0601	transmembrane transport
AM378_02570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM378_02595	COG0583	DNA-binding transcription factor activity
AM378_02600	COG0477	Major facilitator Superfamily
AM378_02605	COG0302	gtp cyclohydrolase
AM378_02610	COG2311	Membrane
AM378_02615	COG1609	Transcriptional regulator
AM378_02635	COG2949	membrane
AM378_02640	COG0281	malic enzyme
AM378_02645	COG0295	cytidine deaminase activity
AM378_02650	COG1346	cytolysis
AM378_02655	COG1380	Effector of murein hydrolase LrgA
AM378_02660	COG2814	Major facilitator Superfamily
AM378_02670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM378_02670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM378_02675	COG0489	protein tyrosine kinase activity
AM378_02685	COG0572	uridine kinase
AM378_02690	COG0717	Belongs to the dCTP deaminase family
AM378_02695	COG2982	Protein involved in outer membrane biogenesis
AM378_02700	COG3069	C4-dicarboxylate transmembrane transporter activity
AM378_02705	COG1253	flavin adenine dinucleotide binding
AM378_02710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM378_02725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM378_02730	COG0489	protein tyrosine kinase activity
AM378_02730	COG3206	protein involved in exopolysaccharide biosynthesis
AM378_02735	COG1083	cytidylyl-transferase
AM378_02740	COG2089	acid synthase
AM378_02745	COG2244	polysaccharide biosynthetic process
AM378_02750	COG0110	maltose O-acetyltransferase activity
AM378_02840	COG1091	dTDP-4-dehydrorhamnose reductase activity
AM378_02880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AM378_02885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM378_02885	COG0140	phosphoribosyl-ATP diphosphatase activity
AM378_02890	COG0107	imidazoleglycerol-phosphate synthase activity
AM378_02895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AM378_02900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM378_02910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM378_02915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM378_02920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM378_02930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_02945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM378_02950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM378_02950	COG3153	acetyltransferase
AM378_02955	COG0598	Magnesium transport protein CorA
AM378_02965	COG2133	pyrroloquinoline quinone binding
AM378_02970	COG0625	glutathione transferase activity
AM378_02985	COG0626	cystathionine gamma-synthase activity
AM378_02995	COG1686	Belongs to the peptidase S11 family
AM378_03020	COG3539	Fimbrial protein
AM378_03025	COG3188	usher protein
AM378_03030	COG3121	Chaperone
AM378_03050	COG0545	Peptidyl-prolyl cis-trans isomerase
AM378_03055	COG2197	response regulator
AM378_03060	COG1760	l-serine dehydratase
AM378_03065	COG0814	amino acid
AM378_03070	COG1349	DNA-binding transcription factor activity
AM378_03075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AM378_03085	COG0671	phosphoesterase, PA-phosphatase related
AM378_03100	COG4574	serine-type endopeptidase inhibitor activity
AM378_03110	COG3395	kinase activity
AM378_03115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM378_03185	COG0569	domain protein
AM378_03185	COG2985	domain, Protein
AM378_03195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM378_03205	COG0189	ligase activity
AM378_03215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM378_03220	COG3842	ATPase activity
AM378_03225	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM378_03230	COG1177	transmembrane transport
AM378_03240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM378_03245	COG2026	Addiction module toxin, RelE StbE family
AM378_03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_03260	COG4160	amino acid transport
AM378_03265	COG4215	(ABC) transporter
AM378_03270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_03275	COG1126	abc transporter atp-binding protein
AM378_03285	COG0393	Putative heavy-metal-binding
AM378_03290	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM378_03295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_03300	COG0702	epimerase
AM378_03310	COG1737	Transcriptional regulator
AM378_03315	COG2190	(PTS) system
AM378_03315	COG1263	PTS System
AM378_03315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_03320	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AM378_03325	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AM378_03330	COG0028	Belongs to the TPP enzyme family
AM378_03335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM378_03340	COG1151	hydroxylamine reductase activity
AM378_03345	COG2431	L-lysine efflux transmembrane transporter activity
AM378_03350	COG3593	DNA synthesis involved in DNA repair
AM378_03355	COG2990	Protein conserved in bacteria
AM378_03360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_03370	COG1278	Cold shock
AM378_03375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM378_03380	COG0542	response to heat
AM378_03385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM378_03390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM378_03395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AM378_03405	COG0492	ferredoxin-NADP+ reductase activity
AM378_03415	COG3107	peptidoglycan biosynthetic process
AM378_03415	COG1674	ftsk spoiiie
AM378_03420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AM378_03425	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM378_03430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AM378_03440	COG2814	Major facilitator Superfamily
AM378_03445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM378_03450	COG1882	Formate acetyltransferase
AM378_03455	COG2116	formate transmembrane transporter activity
AM378_03460	COG1944	ATP diphosphatase activity
AM378_03465	COG0252	asparaginase activity
AM378_03470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AM378_03475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM378_03480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AM378_03485	COG0539	negative regulation of cytoplasmic translation
AM378_03495	COG0658	competence protein
AM378_03495	COG2333	competence protein COMEC
AM378_03500	COG1132	(ABC) transporter
AM378_03505	COG1663	tetraacyldisaccharide 4'-kinase activity
AM378_03510	COG5383	Protein conserved in bacteria
AM378_03515	COG1278	Cold shock
AM378_03520	COG1278	Cold shock
AM378_03525	COG3214	Protein conserved in bacteria
AM378_03530	COG2835	tetraacyldisaccharide 4'-kinase activity
AM378_03535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AM378_03540	COG3173	Aminoglycoside phosphotransferase
AM378_03545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM378_03550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM378_03555	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AM378_03560	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AM378_03565	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AM378_03570	COG2989	Protein conserved in bacteria
AM378_03575	COG3108	Peptidase M15
AM378_03580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM378_03585	COG1448	Aminotransferase
AM378_03600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AM378_03605	COG3706	GGDEF domain
AM378_03610	COG0308	aminopeptidase N
AM378_03620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM378_03625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM378_03630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM378_03635	COG0431	NADPH-dependent FMN reductase
AM378_03640	COG0167	dihydroorotate dehydrogenase activity
AM378_03650	COG0633	Ferredoxin
AM378_03650	COG3217	Mosc domain protein beta barrel domain protein
AM378_03655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AM378_03655	COG0116	Belongs to the methyltransferase superfamily
AM378_03660	COG0488	(ABC) transporter
AM378_03665	COG2995	paraquat-inducible protein a
AM378_03670	COG3008	intermembrane lipid transfer
AM378_03670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM378_03675	COG3009	Protein conserved in bacteria
AM378_03680	COG3130	regulation of translation
AM378_03685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM378_03695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AM378_03700	COG1067	ATP-dependent peptidase activity
AM378_03720	COG3070	regulator of competence-specific genes
AM378_03725	COG1289	transmembrane transporter activity
AM378_03730	COG3304	Inner membrane component domain
AM378_03735	COG0210	DNA helicase
AM378_03740	COG1803	Methylglyoxal synthase
AM378_03750	COG1832	CoA-binding protein
AM378_03755	COG3785	DNA binding
AM378_03760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AM378_03770	COG3594	Acyltransferase
AM378_03775	COG1254	Belongs to the acylphosphatase family
AM378_03780	COG2920	part of a sulfur-relay system
AM378_03785	COG0670	Belongs to the BI1 family
AM378_03810	COG2197	response regulator
AM378_03820	COG3121	Chaperone
AM378_03825	COG3188	usher protein
AM378_03845	COG0789	Transcriptional regulator
AM378_03855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_03860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_03870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM378_03880	COG0655	NAD(P)H dehydrogenase (quinone) activity
AM378_03895	COG1113	amino acid transport
AM378_03905	COG0586	Pfam SNARE associated Golgi protein
AM378_03910	COG2271	Major facilitator Superfamily
AM378_03935	COG2814	Major facilitator Superfamily
AM378_03940	COG0156	8-amino-7-oxononanoate synthase activity
AM378_03945	COG0183	Belongs to the thiolase family
AM378_03950	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM378_03955	COG2197	response regulator
AM378_03960	COG0589	response to stress
AM378_03975	COG0531	amino acid
AM378_03980	COG1012	belongs to the aldehyde dehydrogenase family
AM378_03985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM378_04000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM378_04000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AM378_04010	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM378_04025	COG3136	membrane protein required for alginate biosynthesis
AM378_04035	COG2197	response regulator
AM378_04040	COG0322	excinuclease ABC activity
AM378_04065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM378_04100	COG1538	Outer membrane efflux protein
AM378_04110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_04115	COG0322	excinuclease ABC activity
AM378_04155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AM378_04160	COG2943	transferase activity, transferring hexosyl groups
AM378_04165	COG5645	(Lipo)protein
AM378_04180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM378_04190	COG0640	Transcriptional regulator
AM378_04205	COG0346	lactoylglutathione lyase activity
AM378_04210	COG3104	oligopeptide transport
AM378_04215	COG2814	Major facilitator Superfamily
AM378_04225	COG1560	Kdo2-lipid A biosynthetic process
AM378_04240	COG2353	YceI-like domain
AM378_04245	COG3038	cytochrome b561
AM378_04250	COG0628	permease
AM378_04290	COG0418	dihydroorotase activity
AM378_04295	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM378_04300	COG1530	ribonuclease E activity
AM378_04310	COG0564	pseudouridine synthase activity
AM378_04320	COG1399	metal-binding, possibly nucleic acid-binding protein
AM378_04325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AM378_04330	COG0416	fatty acid biosynthetic process
AM378_04335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM378_04340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM378_04345	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_04350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM378_04355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM378_04360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM378_04365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM378_04370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM378_04375	COG0470	DNA polymerase III
AM378_04380	COG0084	hydrolase, TatD family'
AM378_04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_04385	COG1263	PTS System
AM378_04395	COG1321	iron dependent repressor
AM378_04400	COG1914	H( )-stimulated, divalent metal cation uptake system
AM378_04405	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_04410	COG1733	regulation of RNA biosynthetic process
AM378_04420	COG0537	adenosine 5'-monophosphoramidase activity
AM378_04425	COG5633	Lipoprotein
AM378_04430	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AM378_04445	COG3150	esterase
AM378_04450	COG1252	NADH dehydrogenase
AM378_04455	COG3134	Outer membrane lipoprotein
AM378_04465	COG1943	Transposase
AM378_04480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_04485	COG2207	Transcriptional regulator
AM378_04485	COG3708	Transcriptional regulator
AM378_04510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM378_04515	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AM378_04520	COG3381	protein complex oligomerization
AM378_04525	COG2979	Protein of unknown function (DUF533)
AM378_04530	COG1770	oligopeptidase
AM378_04535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM378_04540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM378_04555	COG1528	Iron-storage protein
AM378_04560	COG2372	response to copper ion
AM378_04565	COG1276	copper resistance
AM378_04590	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM378_04610	COG4565	transcriptional regulatory protein
AM378_04615	COG3290	protein histidine kinase activity
AM378_04630	COG1129	ABC transporter
AM378_04635	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_04650	COG0579	oxidoreductase
AM378_04670	COG1464	Belongs to the NlpA lipoprotein family
AM378_04680	COG0589	response to stress
AM378_04685	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AM378_04685	COG3408	Glycogen debranching enzyme
AM378_04695	COG1609	Transcriptional regulator
AM378_04700	COG3250	beta-galactosidase activity
AM378_04705	COG2731	YhcH YjgK YiaL family protein
AM378_04710	COG0531	amino acid
AM378_04715	COG0640	Transcriptional regulator
AM378_04725	COG0740	serine-type endopeptidase activity
AM378_04750	COG3121	Chaperone
AM378_04790	COG0012	GTP binding
AM378_04795	COG0659	secondary active sulfate transmembrane transporter activity
AM378_04800	COG0193	aminoacyl-tRNA hydrolase activity
AM378_04810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM378_04815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AM378_04820	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AM378_04825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AM378_04830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AM378_04835	COG2890	protein-(glutamine-N5) methyltransferase activity
AM378_04840	COG3094	Invasion gene expression up-regulator, SirB
AM378_04845	COG2912	Transglutaminase-like superfamily
AM378_04850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AM378_04855	COG0659	secondary active sulfate transmembrane transporter activity
AM378_04860	COG4702	Belongs to the UPF0303 family
AM378_04865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM378_04875	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM378_04885	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM378_04895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM378_04900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM378_04910	COG1486	melibiose metabolic process
AM378_04915	COG1263	PTS System
AM378_04915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_04920	COG1177	transmembrane transport
AM378_04925	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM378_04935	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM378_04955	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AM378_04960	COG2850	peptidyl-arginine hydroxylation
AM378_04970	COG0745	RESPONSE REGULATOR receiver
AM378_04975	COG1397	ADP-ribosylglycohydrolase
AM378_04980	COG2188	Transcriptional regulator
AM378_04995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM378_05000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM378_05005	COG2915	High frequency lysogenization protein hflD homolog
AM378_05015	COG0482	sulfurtransferase activity
AM378_05030	COG1187	pseudouridine synthase activity
AM378_05035	COG0538	isocitrate dehydrogenase activity
AM378_05040	COG0589	response to stress
AM378_05055	COG3064	Membrane
AM378_05115	COG1278	Cold shock
AM378_05125	COG1335	isochorismatase
AM378_05130	COG0589	response to stress
AM378_05135	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_05140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM378_05145	COG1012	belongs to the aldehyde dehydrogenase family
AM378_05150	COG1917	Cupin 2, conserved barrel domain protein
AM378_05150	COG1396	sequence-specific DNA binding
AM378_05155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AM378_05160	COG0174	glutamine synthetase
AM378_05170	COG0531	amino acid
AM378_05200	COG1605	Chorismate mutase
AM378_05215	COG1228	amidohydrolase
AM378_05225	COG0402	S-adenosylhomocysteine deaminase activity
AM378_05245	COG2211	Major facilitator Superfamily
AM378_05250	COG0477	Major facilitator Superfamily
AM378_05255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AM378_05260	COG3493	citrate carrier protein
AM378_05320	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AM378_05320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM378_05325	COG3008	intermembrane lipid transfer
AM378_05330	COG2995	paraquat-inducible protein a
AM378_05335	COG1956	GAF domain-containing protein
AM378_05340	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AM378_05345	COG0793	Belongs to the peptidase S41A family
AM378_05350	COG0501	Belongs to the peptidase M48B family
AM378_05360	COG2814	Major facilitator Superfamily
AM378_05365	COG1414	Transcriptional regulator
AM378_05390	COG2188	Transcriptional regulator
AM378_05410	COG1988	membrane-bound metal-dependent
AM378_05415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM378_05435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM378_05440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM378_05445	COG1121	(ABC) transporter
AM378_05450	COG0803	Belongs to the bacterial solute-binding protein 9 family
AM378_05480	COG0814	amino acid
AM378_05505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM378_05515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AM378_05520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM378_05525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AM378_05545	COG4139	cobalamin transport
AM378_05550	COG0386	Belongs to the glutathione peroxidase family
AM378_05555	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AM378_05560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM378_05565	COG1215	transferase activity, transferring glycosyl groups
AM378_05570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM378_05570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_05575	COG0726	polysaccharide deacetylase
AM378_05580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AM378_05585	COG2076	Multidrug Resistance protein
AM378_05590	COG2076	Multidrug Resistance protein
AM378_05595	COG0791	NLP P60 protein
AM378_05600	COG0095	Lipoate-protein ligase
AM378_05620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_05625	COG4558	Periplasmic binding protein
AM378_05630	COG3720	iron ion transport
AM378_05645	COG0386	Belongs to the glutathione peroxidase family
AM378_05650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM378_05655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AM378_05665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM378_05665	COG0574	Belongs to the PEP-utilizing enzyme family
AM378_05675	COG0628	permease
AM378_05680	COG0247	lactate metabolic process
AM378_05680	COG0277	FAD linked oxidase domain protein
AM378_05685	COG2050	protein possibly involved in aromatic compounds catabolism
AM378_05695	COG0316	Belongs to the HesB IscA family
AM378_05700	COG0719	Fe-S assembly protein
AM378_05705	COG0396	ATPase activity
AM378_05710	COG0719	Fe-S assembly protein
AM378_05715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM378_05720	COG2166	iron-sulfur cluster assembly
AM378_05725	COG1376	ErfK ybiS ycfS ynhG family protein
AM378_05725	COG1388	LysM domain
AM378_05735	COG0469	pyruvate kinase activity
AM378_05760	COG0534	Mate efflux family protein
AM378_05765	COG0307	riboflavin synthase, alpha
AM378_05775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AM378_05780	COG2814	Major facilitator Superfamily
AM378_05785	COG0583	DNA-binding transcription factor activity
AM378_05790	COG1609	Transcriptional regulator
AM378_05800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM378_05805	COG0791	NLP P60 protein
AM378_05810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM378_05820	COG0346	lactoylglutathione lyase activity
AM378_05825	COG1902	pentaerythritol trinitrate reductase activity
AM378_05830	COG1309	transcriptional regulator
AM378_05835	COG2194	sulfuric ester hydrolase activity
AM378_05845	COG0583	DNA-binding transcription factor activity
AM378_05850	COG3313	Fe-S protein
AM378_05855	COG4989	oxidoreductase activity
AM378_05860	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AM378_05870	COG1289	transmembrane transporter activity
AM378_05875	COG1566	PFAM secretion protein HlyD family protein
AM378_05885	COG1846	Transcriptional regulator
AM378_05890	COG3133	Outer membrane lipoprotein
AM378_05895	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AM378_05905	COG0259	pyridoxamine-phosphate oxidase activity
AM378_05910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM378_05925	COG0625	glutathione transferase activity
AM378_05940	COG1418	mRNA catabolic process
AM378_05975	COG3135	benzoate transporter
AM378_05980	COG1396	sequence-specific DNA binding
AM378_05985	COG1505	serine-type exopeptidase activity
AM378_05990	COG3104	oligopeptide transport
AM378_05995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM378_06005	COG4659	FMN binding
AM378_06015	COG2207	Transcriptional regulator
AM378_06015	COG3708	Transcriptional regulator
AM378_06020	COG4656	Part of a membrane complex involved in electron transport
AM378_06025	COG2878	Part of a membrane complex involved in electron transport
AM378_06030	COG4657	Part of a membrane complex involved in electron transport
AM378_06040	COG0673	inositol 2-dehydrogenase activity
AM378_06045	COG0385	Bile acid
AM378_06055	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM378_06060	COG1349	DNA-binding transcription factor activity
AM378_06065	COG0494	nUDIX hydrolase
AM378_06075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AM378_06080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_06080	COG1263	PTS System
AM378_06085	COG1609	Transcriptional regulator
AM378_06100	COG0583	DNA-binding transcription factor activity
AM378_06110	COG5339	Protein conserved in bacteria
AM378_06125	COG0114	fumarate hydratase activity
AM378_06130	COG2378	regulation of single-species biofilm formation
AM378_06145	COG1472	Belongs to the glycosyl hydrolase 3 family
AM378_06155	COG2814	Major facilitator Superfamily
AM378_06160	COG0583	DNA-binding transcription factor activity
AM378_06165	COG1940	carbohydrate kinase activity
AM378_06170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM378_06180	COG0789	Transcriptional regulator
AM378_06210	COG0477	Major facilitator Superfamily
AM378_06225	COG1742	UPF0060 membrane protein
AM378_06230	COG4221	oxidoreductase activity
AM378_06240	COG4772	TonB-dependent receptor
AM378_06245	COG3712	iron ion homeostasis
AM378_06250	COG1595	DNA-templated transcription, initiation
AM378_06255	COG0402	S-adenosylhomocysteine deaminase activity
AM378_06305	COG0339	signal peptide processing
AM378_06310	COG2271	Major facilitator Superfamily
AM378_06315	COG1335	isochorismatase
AM378_06320	COG3473	Maleate cis-trans isomerase
AM378_06325	COG0596	Alpha beta hydrolase
AM378_06330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM378_06335	COG2309	aminopeptidase activity
AM378_06340	COG1846	Transcriptional regulator
AM378_06345	COG2080	2 iron, 2 sulfur cluster binding
AM378_06350	COG2010	Cytochrome c
AM378_06350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM378_06360	COG0583	DNA-binding transcription factor activity
AM378_06430	COG4221	oxidoreductase activity
AM378_06435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AM378_06445	COG1280	lysine exporter protein (LysE YggA)
AM378_06450	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_06470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM378_06475	COG1957	nucleoside hydrolase
AM378_06485	COG2140	Oxalate decarboxylase
AM378_06490	COG2190	(PTS) system
AM378_06490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_06490	COG1263	PTS System
AM378_06495	COG2723	6-phospho-beta-galactosidase activity
AM378_06500	COG3711	transcriptional antiterminator
AM378_06535	COG0596	Alpha beta hydrolase
AM378_06600	COG2814	Major facilitator Superfamily
AM378_06620	COG0768	penicillin binding
AM378_06660	COG0583	DNA-binding transcription factor activity
AM378_06670	COG2814	Major facilitator Superfamily
AM378_06680	COG1349	DNA-binding transcription factor activity
AM378_06685	COG0673	inositol 2-dehydrogenase activity
AM378_06690	COG2814	Major facilitator Superfamily
AM378_06735	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM378_06745	COG3453	Protein conserved in bacteria
AM378_06745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM378_06750	COG1064	alcohol dehydrogenase
AM378_06755	COG1012	belongs to the aldehyde dehydrogenase family
AM378_06760	COG3284	Transcriptional regulator
AM378_06770	COG2814	Major facilitator Superfamily
AM378_06775	COG5001	Diguanylate cyclase
AM378_06775	COG3300	MHYT domain
AM378_06795	COG1802	Transcriptional regulator
AM378_06805	COG2267	carboxylic ester hydrolase activity
AM378_06810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM378_06815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM378_06820	COG1012	belongs to the aldehyde dehydrogenase family
AM378_06825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM378_06870	COG0583	DNA-binding transcription factor activity
AM378_06875	COG0076	glutamate decarboxylase activity
AM378_06880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM378_06885	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM378_06885	COG1902	pentaerythritol trinitrate reductase activity
AM378_06895	COG0148	phosphopyruvate hydratase activity
AM378_06905	COG1227	inorganic diphosphatase activity
AM378_06910	COG5001	Diguanylate cyclase
AM378_06910	COG5002	protein histidine kinase activity
AM378_06910	COG3447	MASE1 domain protein
AM378_06935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM378_06940	COG0702	epimerase
AM378_06945	COG0583	DNA-binding transcription factor activity
AM378_06970	COG4221	oxidoreductase activity
AM378_06975	COG4221	oxidoreductase activity
AM378_06990	COG1082	Xylose isomerase domain protein TIM barrel
AM378_06995	COG0673	inositol 2-dehydrogenase activity
AM378_07020	COG0456	acetyltransferase
AM378_07020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM378_07030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM378_07060	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM378_07065	COG1733	regulation of RNA biosynthetic process
AM378_07070	COG0477	Major facilitator Superfamily
AM378_07085	COG2382	esterase
AM378_07090	COG4774	siderophore transport
AM378_07100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM378_07105	COG0318	PFAM AMP-dependent synthetase and ligase
AM378_07110	COG0693	protein deglycase activity
AM378_07125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_07140	COG2957	Belongs to the agmatine deiminase family
AM378_07145	COG0583	DNA-binding transcription factor activity
AM378_07170	COG0778	Nitroreductase
AM378_07175	COG2010	Cytochrome c
AM378_07175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM378_07180	COG2010	Cytochrome c
AM378_07180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM378_07185	COG2080	2 iron, 2 sulfur cluster binding
AM378_07190	COG1737	Transcriptional regulator
AM378_07195	COG2723	6-phospho-beta-galactosidase activity
AM378_07205	COG2814	Major facilitator Superfamily
AM378_07210	COG3048	D-serine ammonia-lyase activity
AM378_07220	COG5507	3-demethylubiquinone-9 3-methyltransferase
AM378_07225	COG2199	diguanylate cyclase activity
AM378_07250	COG1012	belongs to the aldehyde dehydrogenase family
AM378_07255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM378_07260	COG0697	spore germination
AM378_07265	COG2271	Major facilitator Superfamily
AM378_07280	COG3264	Mechanosensitive ion channel
AM378_07280	COG1196	nuclear chromosome segregation
AM378_07285	COG0488	(ABC) transporter
AM378_07295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_07300	COG0483	inositol monophosphate 1-phosphatase activity
AM378_07305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AM378_07315	COG2239	Acts as a magnesium transporter
AM378_07340	COG0697	spore germination
AM378_07405	COG0411	ABC transporter
AM378_07445	COG0306	phosphate transporter
AM378_07465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM378_07485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AM378_07490	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AM378_07505	COG2222	sugar isomerase
AM378_07520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM378_07530	COG0589	response to stress
AM378_07535	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM378_07540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM378_07550	COG0531	amino acid
AM378_07575	COG0745	RESPONSE REGULATOR receiver
AM378_07580	COG2205	protein histidine kinase activity
AM378_07585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AM378_07590	COG2267	carboxylic ester hydrolase activity
AM378_07600	COG3591	Belongs to the peptidase S1B family
AM378_07605	COG1643	Atp-dependent helicase
AM378_07610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM378_07620	COG3784	Protein of unknown function (DUF1318)
AM378_07630	COG2911	Protein conserved in bacteria
AM378_07645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM378_07650	COG3187	Heat shock protein
AM378_07655	COG3042	response to heat
AM378_07665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AM378_07665	COG1013	pyruvate-flavodoxin oxidoreductase activity
AM378_07665	COG0674	pyruvate-flavodoxin oxidoreductase activity
AM378_07665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM378_07670	COG0037	tRNA processing
AM378_07700	COG4166	transmembrane transport
AM378_07710	COG2866	Carboxypeptidase
AM378_07715	COG4948	Mandelate Racemase Muconate Lactonizing
AM378_07720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AM378_07730	COG3768	UPF0283 membrane protein
AM378_07735	COG3106	COG3106 Predicted ATPase
AM378_07745	COG1983	PspC domain protein
AM378_07755	COG1842	Phage shock protein A
AM378_07760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AM378_07770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM378_07775	COG1469	GTP cyclohydrolase I activity
AM378_07785	COG4168	peptide transport system, permease
AM378_07790	COG4171	peptide transport system, permease
AM378_07795	COG4172	Belongs to the ABC transporter superfamily
AM378_07800	COG4172	Belongs to the ABC transporter superfamily
AM378_07810	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM378_07810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM378_07830	COG0243	molybdopterin cofactor binding
AM378_07845	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AM378_07850	COG0477	Major facilitator Superfamily
AM378_07855	COG1473	amidohydrolase
AM378_07860	COG1966	Carbon starvation protein
AM378_07880	COG3210	domain, Protein
AM378_07910	COG2831	hemolysin activation secretion protein
AM378_07915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM378_07920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM378_07930	COG1349	DNA-binding transcription factor activity
AM378_07940	COG0023	Translation Initiation Factor
AM378_07960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AM378_07965	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AM378_07970	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_07975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM378_07980	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_07985	COG1129	ABC transporter
AM378_07995	COG1879	ABC-type sugar transport system periplasmic component
AM378_08000	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_08005	COG3958	Transketolase
AM378_08010	COG3959	Transketolase, thiamine diphosphate binding domain
AM378_08015	COG1349	DNA-binding transcription factor activity
AM378_08020	COG0671	phosphoesterase, PA-phosphatase related
AM378_08030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM378_08035	COG0583	DNA-binding transcription factor activity
AM378_08040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM378_08050	COG0616	signal peptide processing
AM378_08055	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_08060	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AM378_08065	COG1187	pseudouridine synthase activity
AM378_08080	COG0009	L-threonylcarbamoyladenylate synthase
AM378_08085	COG0613	PHP domain protein
AM378_08100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM378_08110	COG0133	tryptophan synthase activity
AM378_08115	COG0159	tryptophan synthase activity
AM378_08145	COG2917	probably involved in intracellular septation
AM378_08150	COG1607	acyl-coa hydrolase
AM378_08160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM378_08165	COG2350	Protein conserved in bacteria
AM378_08175	COG0583	DNA-binding transcription factor activity
AM378_08185	COG1609	Transcriptional regulator
AM378_08205	COG1070	Carbohydrate kinase
AM378_08210	COG1129	ABC transporter
AM378_08215	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_08220	COG1879	ABC-type sugar transport system periplasmic component
AM378_08235	COG0783	Belongs to the Dps family
AM378_08245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM378_08250	COG3099	Belongs to the UPF0263 family
AM378_08260	COG0444	Belongs to the ABC transporter superfamily
AM378_08265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM378_08280	COG4166	transmembrane transport
AM378_08285	COG2095	MarC family integral membrane protein
AM378_08290	COG1012	belongs to the aldehyde dehydrogenase family
AM378_08290	COG1454	alcohol dehydrogenase
AM378_08295	COG1435	thymidine kinase activity
AM378_08315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM378_08320	COG0745	RESPONSE REGULATOR receiver
AM378_08325	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM378_08330	COG3012	SEC-C Motif Domain Protein
AM378_08335	COG0788	formyltetrahydrofolate deformylase activity
AM378_08370	COG0708	Exodeoxyribonuclease III
AM378_08375	COG0494	nUDIX hydrolase
AM378_08385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM378_08390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AM378_08400	COG0778	Nitroreductase
AM378_08405	COG0616	signal peptide processing
AM378_08410	COG0252	asparaginase activity
AM378_08415	COG1335	isochorismatase
AM378_08425	COG3139	Protein of unknown function (DUF1315)
AM378_08430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM378_08440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM378_08450	COG3713	MltA-interacting MipA family protein
AM378_08455	COG2766	serine protein kinase
AM378_08460	COG2718	Belongs to the UPF0229 family
AM378_08510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM378_08515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM378_08525	COG3443	Belongs to the bacterial solute-binding protein 9 family
AM378_08530	COG2719	SpoVR family
AM378_08535	COG2186	Transcriptional regulator
AM378_08540	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM378_08545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AM378_08550	COG2983	Belongs to the UPF0260 family
AM378_08555	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM378_08560	COG2951	lytic endotransglycosylase activity
AM378_08565	COG3100	YcgL domain-containing protein
AM378_08570	COG0850	regulation of cytokinetic process
AM378_08575	COG2894	cell division
AM378_08580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AM378_08585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AM378_08590	COG0318	PFAM AMP-dependent synthetase and ligase
AM378_08595	COG3065	identical protein binding
AM378_08605	COG1199	ATP-dependent helicase activity
AM378_08610	COG0251	oxidation-reduction process
AM378_08615	COG2076	Multidrug Resistance protein
AM378_08620	COG2076	Multidrug Resistance protein
AM378_08625	COG0800	Aldolase
AM378_08630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM378_08635	COG1737	Transcriptional regulator
AM378_08640	COG0469	pyruvate kinase activity
AM378_08650	COG1560	Kdo2-lipid A biosynthetic process
AM378_08655	COG0739	heme binding
AM378_08660	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AM378_08665	COG1121	(ABC) transporter
AM378_08670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM378_08675	COG2255	four-way junction helicase activity
AM378_08680	COG0632	four-way junction helicase activity
AM378_08685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AM378_08690	COG0217	transcriptional regulatory protein
AM378_08695	COG0494	nUDIX hydrolase
AM378_08700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM378_08710	COG1335	isochorismatase
AM378_08715	COG1801	Protein of unknown function DUF72
AM378_08720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AM378_08725	COG2226	methyltransferase
AM378_08730	COG0500	methyltransferase
AM378_08735	COG0545	Peptidyl-prolyl cis-trans isomerase
AM378_08745	COG3142	Participates in the control of copper homeostasis
AM378_08750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AM378_08755	COG3102	Protein conserved in bacteria
AM378_08760	COG0018	arginyl-trna synthetase
AM378_08770	COG0673	inositol 2-dehydrogenase activity
AM378_08775	COG3132	Protein of unknown function, DUF480
AM378_08780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM378_08785	COG0477	Major facilitator Superfamily
AM378_08795	COG2999	glutathione oxidoreductase activity
AM378_08820	COG3141	response to X-ray
AM378_08825	COG0513	Belongs to the DEAD box helicase family
AM378_08830	COG1278	Cold shock
AM378_08835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AM378_08840	COG3140	Belongs to the UPF0181 family
AM378_08845	COG1216	Glycosyl transferase, family 2
AM378_08855	COG0494	nUDIX hydrolase
AM378_08860	COG1760	l-serine dehydratase
AM378_08865	COG2200	EAL domain
AM378_08870	COG1253	flavin adenine dinucleotide binding
AM378_08875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_08875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_08880	COG3715	PTS system
AM378_08885	COG3716	PTS system mannose fructose sorbose family IID component
AM378_08890	COG4811	Protein of unknown function (DUF986)
AM378_08895	COG1971	Probably functions as a manganese efflux pump
AM378_08900	COG2226	methyltransferase
AM378_08910	COG1278	Cold shock
AM378_08930	COG1113	amino acid transport
AM378_08975	COG2207	Transcriptional regulator
AM378_08990	COG1652	LysM domain
AM378_09015	COG2988	succinylglutamate desuccinylase activity
AM378_09020	COG3724	N-succinylarginine dihydrolase activity
AM378_09025	COG1012	belongs to the aldehyde dehydrogenase family
AM378_09030	COG3138	arginine N-succinyltransferase
AM378_09035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM378_09045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM378_09050	COG1271	oxidase subunit
AM378_09055	COG1294	oxidase, subunit
AM378_09105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_09110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM378_09115	COG2181	nitrate reductase activity
AM378_09120	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AM378_09125	COG1140	nitrate reductase beta subunit
AM378_09130	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AM378_09180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM378_09185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_09190	COG3710	Transcriptional regulator
AM378_09195	COG2223	nitrite transmembrane transporter activity
AM378_09200	COG3850	Histidine kinase
AM378_09205	COG2197	response regulator
AM378_09210	COG4932	domain protein
AM378_09225	COG4608	Belongs to the ABC transporter superfamily
AM378_09230	COG0444	Belongs to the ABC transporter superfamily
AM378_09235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM378_09240	COG0601	transmembrane transport
AM378_09250	COG0583	DNA-binding transcription factor activity
AM378_09255	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AM378_09260	COG4572	Cation transport regulator
AM378_09265	COG2375	cellular response to nickel ion
AM378_09270	COG0387	Pfam Sodium calcium exchanger
AM378_09330	COG5301	cellulose 1,4-beta-cellobiosidase activity
AM378_09420	COG4695	Portal protein
AM378_09430	COG0419	ATPase involved in DNA repair
AM378_09480	COG4974	Belongs to the 'phage' integrase family
AM378_09485	COG1702	phosphate starvation-inducible protein PhoH
AM378_09510	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM378_09510	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM378_09510	COG0506	proline dehydrogenase activity
AM378_09530	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AM378_09540	COG1191	sigma factor activity
AM378_09585	COG0583	DNA-binding transcription factor activity
AM378_09600	COG1677	Flagellar hook-basal body complex protein FliE
AM378_09610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AM378_09615	COG1317	bacterial-type flagellum organization
AM378_09620	COG1157	protein secretion by the type III secretion system
AM378_09625	COG2882	bacterial-type flagellum organization
AM378_09660	COG1987	bacterial-type flagellum assembly
AM378_09680	COG1256	bacterial-type flagellum assembly
AM378_09705	COG4786	Flagellar basal body rod
AM378_09715	COG1749	Flagellar hook protein flgE
AM378_09720	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AM378_09725	COG1558	bacterial-type flagellum-dependent cell motility
AM378_09730	COG1815	bacterial-type flagellum-dependent cell motility
AM378_09740	COG2747	anti-sigma28 factor FlgM
AM378_09745	COG3418	PFAM FlgN family protein
AM378_09765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AM378_09770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AM378_09775	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AM378_09780	COG0745	RESPONSE REGULATOR receiver
AM378_09790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AM378_09795	COG0840	transmembrane signaling receptor activity
AM378_09800	COG0840	transmembrane signaling receptor activity
AM378_09805	COG0835	chemotaxis
AM378_09810	COG0643	Histidine kinase
AM378_09810	COG2198	Histidine kinase
AM378_09845	COG0589	response to stress
AM378_09850	COG2130	NADP-dependent
AM378_09855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AM378_09865	COG3501	Rhs element vgr protein
AM378_10025	COG3501	Rhs element vgr protein
AM378_10030	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AM378_10035	COG3483	tryptophan 2,3-dioxygenase activity
AM378_10040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM378_10050	COG3059	membrane
AM378_10055	COG2207	Transcriptional regulator
AM378_10060	COG1609	Transcriptional regulator
AM378_10085	COG1335	isochorismatase
AM378_10090	COG4977	sequence-specific DNA binding
AM378_10095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM378_10105	COG3712	iron ion homeostasis
AM378_10110	COG1595	DNA-templated transcription, initiation
AM378_10115	COG1629	transport
AM378_10120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM378_10150	COG3781	membrane
AM378_10155	COG2837	iron assimilation
AM378_10165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM378_10175	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AM378_10200	COG1285	pathogenesis
AM378_10210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM378_10220	COG0076	glutamate decarboxylase activity
AM378_10245	COG1278	Cold shock
AM378_10260	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_10260	COG3321	synthase
AM378_10260	COG0604	alcohol dehydrogenase
AM378_10270	COG0583	DNA-binding transcription factor activity
AM378_10275	COG3753	Protein conserved in bacteria
AM378_10280	COG2261	transglycosylase associated protein
AM378_10290	COG1560	Kdo2-lipid A biosynthetic process
AM378_10295	COG2764	glyoxalase bleomycin resistance protein dioxygenase
AM378_10305	COG4251	negative regulation of phosphorylation
AM378_10305	COG5001	Diguanylate cyclase
AM378_10305	COG3706	GGDEF domain
AM378_10305	COG2203	Gaf domain
AM378_10315	COG2030	dehydratase
AM378_10315	COG1012	belongs to the aldehyde dehydrogenase family
AM378_10320	COG3396	Phenylacetate-CoA oxygenase
AM378_10325	COG3460	Phenylacetate-CoA oxygenase
AM378_10330	COG3396	Phenylacetate-CoA oxygenase
AM378_10335	COG2151	metal-sulfur cluster biosynthetic enzyme
AM378_10340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM378_10345	COG1024	Enoyl-CoA hydratase
AM378_10350	COG1024	Enoyl-CoA hydratase
AM378_10355	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM378_10360	COG2050	protein possibly involved in aromatic compounds catabolism
AM378_10365	COG0183	Belongs to the thiolase family
AM378_10370	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AM378_10375	COG3327	negative regulation of DNA-templated transcription, initiation
AM378_10380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM378_10385	COG1113	amino acid transport
AM378_10405	COG0583	DNA-binding transcription factor activity
AM378_10410	COG0625	glutathione transferase activity
AM378_10445	COG0667	Aldo Keto reductase
AM378_10455	COG4772	TonB-dependent receptor
AM378_10460	COG4993	Dehydrogenase
AM378_10495	COG3539	Fimbrial protein
AM378_10505	COG3121	Chaperone
AM378_10510	COG3188	usher protein
AM378_10515	COG3539	Fimbrial protein
AM378_10530	COG0534	Mate efflux family protein
AM378_10560	COG1414	Transcriptional regulator
AM378_10565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM378_10570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM378_10575	COG0183	Belongs to the thiolase family
AM378_10585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM378_10590	COG0583	DNA-binding transcription factor activity
AM378_10595	COG3485	protocatechuate 3,4-dioxygenase
AM378_10600	COG3485	protocatechuate 3,4-dioxygenase
AM378_10625	COG3228	Belongs to the MtfA family
AM378_10635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM378_10640	COG4977	sequence-specific DNA binding
AM378_10650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM378_10655	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM378_10660	COG1116	anion transmembrane transporter activity
AM378_10665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM378_10670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM378_10685	COG0656	L-ascorbic acid biosynthetic process
AM378_10700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM378_10715	COG3238	Protein conserved in bacteria
AM378_10720	COG1247	-acetyltransferase
AM378_10740	COG0583	DNA-binding transcription factor activity
AM378_10750	COG0859	PFAM glycosyl transferase family 9
AM378_10770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM378_10790	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_10795	COG1169	isochorismate synthase
AM378_10810	COG0471	metal ion transport
AM378_10815	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AM378_10825	COG3051	citrate lyase alpha subunit
AM378_10830	COG2301	Belongs to the HpcH HpaI aldolase family
AM378_10835	COG3052	prosthetic group binding
AM378_10840	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AM378_10845	COG4565	transcriptional regulatory protein
AM378_10850	COG3250	beta-galactosidase activity
AM378_10860	COG0300	oxidoreductase activity
AM378_10865	COG2207	Transcriptional regulator
AM378_10880	COG2197	response regulator
AM378_10890	COG1121	(ABC) transporter
AM378_10910	COG2814	Major facilitator Superfamily
AM378_10915	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM378_10935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AM378_10955	COG2070	2-Nitropropane dioxygenase
AM378_10975	COG2271	Major facilitator Superfamily
AM378_11000	COG0410	ABC transporter
AM378_11005	COG0411	ABC transporter
AM378_11055	COG0583	DNA-binding transcription factor activity
AM378_11065	COG0456	acetyltransferase
AM378_11080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM378_11085	COG0156	8-amino-7-oxononanoate synthase activity
AM378_11090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM378_11095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM378_11100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM378_11105	COG2244	polysaccharide biosynthetic process
AM378_11115	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AM378_11120	COG0795	lipopolysaccharide-transporting ATPase activity
AM378_11145	COG0583	DNA-binding transcription factor activity
AM378_11160	COG5290	Psort location Cytoplasmic, score
AM378_11165	COG1609	Transcriptional regulator
AM378_11175	COG3623	hexulose-6-phosphate isomerase
AM378_11180	COG1070	Carbohydrate kinase
AM378_11185	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_11195	COG1879	ABC-type sugar transport system periplasmic component
AM378_11200	COG1063	alcohol dehydrogenase
AM378_11210	COG1473	amidohydrolase
AM378_11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_11220	COG2926	Belongs to the UPF0265 family
AM378_11225	COG1289	transmembrane transporter activity
AM378_11230	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM378_11255	COG2925	Exonuclease
AM378_11260	COG0531	amino acid
AM378_11270	COG0174	glutamine synthetase
AM378_11275	COG1917	Cupin 2, conserved barrel domain protein
AM378_11275	COG1396	sequence-specific DNA binding
AM378_11280	COG1129	ABC transporter
AM378_11285	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_11290	COG4771	TonB-dependent receptor
AM378_11305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_11315	COG0833	amino acid
AM378_11320	COG0583	DNA-binding transcription factor activity
AM378_11330	COG2855	membrane
AM378_11335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AM378_11340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM378_11340	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM378_11340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM378_11345	COG1105	Belongs to the carbohydrate kinase PfkB family
AM378_11350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_11350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_11360	COG0494	nUDIX hydrolase
AM378_11365	COG3005	denitrification pathway
AM378_11370	COG0243	molybdopterin cofactor binding
AM378_11390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AM378_11395	COG1312	Catalyzes the dehydration of D-mannonate
AM378_11400	COG0246	Mannitol dehydrogenase
AM378_11410	COG0523	cobalamin synthesis protein
AM378_11415	COG0671	phosphoesterase, PA-phosphatase related
AM378_11425	COG0791	NLP P60 protein
AM378_11430	COG2200	EAL domain
AM378_11435	COG4166	transmembrane transport
AM378_11440	COG4174	ABC transporter (Permease)
AM378_11445	COG4239	(ABC) transporter, permease
AM378_11450	COG4172	Belongs to the ABC transporter superfamily
AM378_11460	COG2814	Major facilitator Superfamily
AM378_11465	COG1187	pseudouridine synthase activity
AM378_11470	COG1061	Type III restriction enzyme res subunit
AM378_11475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AM378_11480	COG3081	Nucleoid-associated protein
AM378_11485	COG3082	Protein of unknown function (DUF1414)
AM378_11490	COG3083	sulfuric ester hydrolase activity
AM378_11500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM378_11505	COG0625	glutathione transferase activity
AM378_11520	COG2271	Major facilitator Superfamily
AM378_11570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM378_11585	COG0346	lactoylglutathione lyase activity
AM378_11600	COG2223	nitrite transmembrane transporter activity
AM378_11605	COG0642	Histidine kinase
AM378_11605	COG2198	Histidine kinase
AM378_11610	COG2197	response regulator
AM378_11615	COG0784	Response regulator, receiver
AM378_11615	COG2205	protein histidine kinase activity
AM378_11625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM378_11630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM378_11640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM378_11665	COG0814	amino acid
AM378_11680	COG0318	PFAM AMP-dependent synthetase and ligase
AM378_11690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AM378_11695	COG0596	Alpha beta hydrolase
AM378_11700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AM378_11705	COG4575	ribosome binding
AM378_11710	COG1063	alcohol dehydrogenase
AM378_11715	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_11720	COG1609	Transcriptional regulator
AM378_11735	COG0583	DNA-binding transcription factor activity
AM378_11740	COG1007	ATP synthesis coupled electron transport
AM378_11745	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM378_11750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM378_11755	COG0713	ATP synthesis coupled electron transport
AM378_11760	COG0839	Belongs to the complex I subunit 6 family
AM378_11770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AM378_11775	COG1034	ATP synthesis coupled electron transport
AM378_11785	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AM378_11790	COG0649	NAD binding
AM378_11790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM378_11795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM378_11800	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM378_11805	COG0583	DNA-binding transcription factor activity
AM378_11810	COG0436	Aminotransferase
AM378_11815	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AM378_11820	COG0471	metal ion transport
AM378_11820	COG0490	domain, Protein
AM378_11825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM378_11830	COG3013	Belongs to the UPF0304 family
AM378_11835	COG3092	negative regulation of chromosome organization
AM378_11840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM378_11845	COG0280	phosphate acetyltransferase
AM378_11845	COG0857	belongs to the CobB CobQ family
AM378_11860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AM378_11865	COG3959	Transketolase, thiamine diphosphate binding domain
AM378_11870	COG3037	sugar-specific permease SgaT UlaA
AM378_11880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_11885	COG1609	Transcriptional regulator
AM378_11890	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AM378_11895	COG0622	Phosphoesterase
AM378_11900	COG0625	glutathione transferase activity
AM378_11905	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM378_11910	COG1090	epimerase
AM378_11915	COG4598	ABC transporter
AM378_11920	COG4160	amino acid transport
AM378_11925	COG4215	(ABC) transporter
AM378_11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_11935	COG0163	prenyltransferase activity
AM378_11940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AM378_11945	COG1286	toxin biosynthetic process
AM378_11950	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AM378_11955	COG0285	dihydrofolate synthase activity
AM378_11960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AM378_11965	COG0586	Pfam SNARE associated Golgi protein
AM378_11975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM378_11980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM378_11990	COG0697	spore germination
AM378_11995	COG0642	Histidine kinase
AM378_12035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM378_12040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM378_12080	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM378_12085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AM378_12100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM378_12105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM378_12105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AM378_12115	COG3101	peptidyl-lysine hydroxylation
AM378_12120	COG0730	response to heat
AM378_12130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AM378_12135	COG2890	protein-(glutamine-N5) methyltransferase activity
AM378_12140	COG2840	Smr protein MutS2
AM378_12145	COG2062	phosphohistidine phosphatase, SixA
AM378_12150	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM378_12150	COG1024	Enoyl-CoA hydratase
AM378_12155	COG0183	Belongs to the thiolase family
AM378_12160	COG3691	Protein conserved in bacteria
AM378_12175	COG4235	cytochrome complex assembly
AM378_12175	COG3088	subunit of a heme lyase
AM378_12180	COG3088	subunit of a heme lyase
AM378_12180	COG4235	cytochrome complex assembly
AM378_12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM378_12190	COG1138	Cytochrome C-type biogenesis protein
AM378_12195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AM378_12200	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM378_12205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM378_12210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM378_12220	COG2116	formate transmembrane transporter activity
AM378_12230	COG2706	6-phosphogluconolactonase activity
AM378_12235	COG3708	Transcriptional regulator
AM378_12235	COG2207	Transcriptional regulator
AM378_12250	COG2197	response regulator
AM378_12260	COG0583	DNA-binding transcription factor activity
AM378_12270	COG0697	spore germination
AM378_12285	COG2951	lytic endotransglycosylase activity
AM378_12300	COG1215	transferase activity, transferring glycosyl groups
AM378_12305	COG0726	polysaccharide deacetylase
AM378_12305	COG1649	PFAM Uncharacterised BCR, COG1649
AM378_12310	COG0457	Tetratricopeptide repeat
AM378_12315	COG1598	PFAM Uncharacterised protein family UPF0150
AM378_12325	COG3038	cytochrome b561
AM378_12330	COG0436	Aminotransferase
AM378_12345	COG3275	phosphorelay sensor kinase activity
AM378_12350	COG3279	Response regulator of the LytR AlgR family
AM378_12360	COG2223	nitrite transmembrane transporter activity
AM378_12375	COG1794	racemase activity, acting on amino acids and derivatives
AM378_12390	COG3961	Belongs to the TPP enzyme family
AM378_12395	COG0667	Aldo Keto reductase
AM378_12405	COG1914	H( )-stimulated, divalent metal cation uptake system
AM378_12410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM378_12425	COG3121	Chaperone
AM378_12430	COG3188	usher protein
AM378_12455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM378_12485	COG4592	Periplasmic binding protein
AM378_12490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_12495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_12500	COG1120	ATPase activity
AM378_12505	COG2382	esterase
AM378_12510	COG4774	siderophore transport
AM378_12515	COG0747	negative chemotaxis
AM378_12535	COG4302	ethanolamine ammonia-lyase activity
AM378_12540	COG4303	Ethanolamine ammonia lyase large subunit
AM378_12555	COG0583	DNA-binding transcription factor activity
AM378_12560	COG0385	Bile acid
AM378_12565	COG3530	Putative quorum-sensing-regulated virulence factor
AM378_12570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM378_12575	COG3115	cell septum assembly
AM378_12580	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AM378_12585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM378_12590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_12595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM378_12600	COG2190	(PTS) system
AM378_12605	COG2205	protein histidine kinase activity
AM378_12610	COG0745	RESPONSE REGULATOR receiver
AM378_12625	COG4208	sulfate ABC transporter
AM378_12630	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM378_12640	COG2837	iron assimilation
AM378_12655	COG3111	PFAM Bacterial OB fold (BOF) protein
AM378_12660	COG0456	acetyltransferase
AM378_12665	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM378_12670	COG0408	coproporphyrinogen oxidase activity
AM378_12675	COG1671	Belongs to the UPF0178 family
AM378_12685	COG1770	oligopeptidase
AM378_12700	COG0833	amino acid
AM378_12705	COG2040	homocysteine
AM378_12710	COG0281	malic enzyme
AM378_12710	COG0280	phosphate acetyltransferase
AM378_12735	COG0583	DNA-binding transcription factor activity
AM378_12740	COG3397	chitin binding
AM378_12745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM378_12750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM378_12755	COG0494	nUDIX hydrolase
AM378_12765	COG3850	Histidine kinase
AM378_12770	COG2197	response regulator
AM378_12780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_12800	COG1393	Belongs to the ArsC family
AM378_12805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AM378_12810	COG1876	peptidase activity
AM378_12820	COG0400	carboxylic ester hydrolase activity
AM378_12825	COG1444	tRNA N-acetyltransferase activity
AM378_12830	COG2321	neutral zinc metallopeptidase
AM378_12835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AM378_12840	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AM378_12845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM378_12850	COG2716	regulation of RNA biosynthetic process
AM378_12855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM378_12860	COG0628	permease
AM378_12905	COG4783	chaperone-mediated protein folding
AM378_12910	COG1393	Belongs to the ArsC family
AM378_12915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM378_12925	COG2261	transglycosylase associated protein
AM378_12935	COG2233	PERMEase
AM378_12940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AM378_12945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AM378_12950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM378_12955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM378_12985	COG3210	domain, Protein
AM378_13010	COG0573	inorganic phosphate transmembrane transporter activity
AM378_13015	COG0573	inorganic phosphate transmembrane transporter activity
AM378_13020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AM378_13025	COG0248	Ppx GppA phosphatase
AM378_13035	COG2239	Acts as a magnesium transporter
AM378_13040	COG5002	protein histidine kinase activity
AM378_13040	COG5001	Diguanylate cyclase
AM378_13040	COG3447	MASE1 domain protein
AM378_13055	COG0443	Heat shock 70 kDa protein
AM378_13070	COG0667	Aldo Keto reductase
AM378_13075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_13080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_13085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM378_13090	COG2814	Major facilitator Superfamily
AM378_13095	COG2205	protein histidine kinase activity
AM378_13100	COG0745	RESPONSE REGULATOR receiver
AM378_13115	COG3422	double-strand break repair
AM378_13125	COG1597	lipid kinase activity
AM378_13130	COG1830	Aldolase
AM378_13140	COG3730	PTS system glucitol sorbitol-specific
AM378_13155	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_13160	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_13165	COG1349	DNA-binding transcription factor activity
AM378_13180	COG0351	phosphomethylpyrimidine kinase
AM378_13185	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AM378_13200	COG2814	Major facilitator Superfamily
AM378_13220	COG1187	pseudouridine synthase activity
AM378_13240	COG0784	Response regulator, receiver
AM378_13240	COG2205	protein histidine kinase activity
AM378_13240	COG5002	protein histidine kinase activity
AM378_13250	COG1733	regulation of RNA biosynthetic process
AM378_13255	COG0519	Catalyzes the synthesis of GMP from XMP
AM378_13255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM378_13260	COG0517	IMP dehydrogenase activity
AM378_13260	COG0516	GMP reductase activity
AM378_13270	COG1570	exodeoxyribonuclease VII activity
AM378_13280	COG2271	Major facilitator Superfamily
AM378_13285	COG1609	Transcriptional regulator
AM378_13300	COG1645	bacterial-type flagellum-dependent swarming motility
AM378_13310	COG1160	GTP binding
AM378_13315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM378_13320	COG2976	Protein conserved in bacteria
AM378_13325	COG0124	histidyl-tRNA synthetase
AM378_13330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AM378_13335	COG1426	Protein conserved in bacteria
AM378_13345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AM378_13350	COG0105	UTP biosynthetic process
AM378_13360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM378_13365	COG2975	iron-sulfur cluster assembly
AM378_13370	COG0633	Ferredoxin
AM378_13375	COG0443	Heat shock 70 kDa protein
AM378_13380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AM378_13385	COG0316	Belongs to the HesB IscA family
AM378_13390	COG0822	iron-sulfur transferase activity
AM378_13395	COG1104	cysteine desulfurase activity
AM378_13400	COG1959	2 iron, 2 sulfur cluster binding
AM378_13415	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AM378_13420	COG3683	transport system, periplasmic component
AM378_13425	COG3711	transcriptional antiterminator
AM378_13430	COG2814	Major facilitator Superfamily
AM378_13435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AM378_13440	COG1017	nitric oxide dioxygenase activity
AM378_13440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM378_13450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AM378_13455	COG1012	belongs to the aldehyde dehydrogenase family
AM378_13460	COG1177	transmembrane transport
AM378_13465	COG1176	ABC-type spermidine putrescine transport system, permease component I
AM378_13470	COG3842	ATPase activity
AM378_13475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AM378_13485	COG0583	DNA-binding transcription factor activity
AM378_13500	COG0347	Belongs to the P(II) protein family
AM378_13505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AM378_13505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM378_13510	COG2204	response regulator
AM378_13515	COG3170	Tfp pilus assembly protein FimV
AM378_13520	COG2205	protein histidine kinase activity
AM378_13530	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AM378_13535	COG0590	tRNA wobble adenosine to inosine editing
AM378_13545	COG0560	Phosphoserine phosphatase
AM378_13550	COG1263	PTS System
AM378_13550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_13555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AM378_13560	COG1737	Transcriptional regulator
AM378_13565	COG2194	sulfuric ester hydrolase activity
AM378_13570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM378_13575	COG0736	holo-[acyl-carrier-protein] synthase activity
AM378_13580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM378_13585	COG1381	Involved in DNA repair and RecF pathway recombination
AM378_13590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM378_13595	COG0571	ribonuclease III activity
AM378_13600	COG0681	Belongs to the peptidase S26 family
AM378_13605	COG0481	GTPase activity
AM378_13615	COG3086	response to oxidative stress
AM378_13620	COG3026	antisigma factor binding
AM378_13635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AM378_13640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AM378_13645	COG0513	Belongs to the DEAD box helicase family
AM378_13665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AM378_13670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AM378_13675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM378_13680	COG0497	DNA recombination
AM378_13685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM378_13690	COG2914	Belongs to the UPF0125 (RnfH) family
AM378_13695	COG2867	negative regulation of translational initiation
AM378_13700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AM378_13710	COG0582	viral genome integration into host DNA
AM378_13840	COG3182	Iron-regulated membrane protein
AM378_13855	COG2264	protein methyltransferase activity
AM378_13880	COG2388	GCN5-related N-acetyl-transferase
AM378_13885	COG3592	Divergent 4Fe-4S mono-cluster
AM378_13890	COG2259	Doxx family
AM378_13895	COG2840	Smr protein MutS2
AM378_13915	COG0477	Major facilitator Superfamily
AM378_13925	COG0477	Major facilitator Superfamily
AM378_13940	COG4575	ribosome binding
AM378_13950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM378_13955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM378_13960	COG1780	Probably involved in ribonucleotide reductase function
AM378_13990	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_13995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AM378_14000	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM378_14005	COG3493	citrate carrier protein
AM378_14025	COG4176	ABC-type proline glycine betaine transport system permease component
AM378_14030	COG2113	Glycine betaine
AM378_14035	COG0583	DNA-binding transcription factor activity
AM378_14040	COG2814	Major facilitator Superfamily
AM378_14045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM378_14055	COG1846	Transcriptional regulator
AM378_14065	COG1566	PFAM secretion protein HlyD family protein
AM378_14070	COG2814	Major facilitator Superfamily
AM378_14075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM378_14080	COG3118	belongs to the thioredoxin family
AM378_14090	COG1042	CoA-binding domain protein
AM378_14090	COG0045	succinate-CoA ligase (ADP-forming) activity
AM378_14090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM378_14095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM378_14100	COG0477	Major facilitator Superfamily
AM378_14135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AM378_14145	COG2011	ABC-type metal ion transport system permease component
AM378_14160	COG1720	tRNA m6t6A37 methyltransferase activity
AM378_14165	COG0442	prolyl-tRNA aminoacylation
AM378_14170	COG3015	lipoprotein NlpE involved in copper resistance
AM378_14175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AM378_14180	COG4681	YaeQ
AM378_14190	COG4568	rho-dependent transcription termination
AM378_14200	COG0037	tRNA processing
AM378_14205	COG3104	oligopeptide transport
AM378_14210	COG1982	Orn Lys Arg decarboxylase major
AM378_14215	COG0531	amino acid
AM378_14220	COG3710	Transcriptional regulator
AM378_14225	COG0346	lactoylglutathione lyase activity
AM378_14240	COG0825	malonyl-CoA metabolic process
AM378_14245	COG0587	DNA-directed DNA polymerase activity
AM378_14250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM378_14255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM378_14260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM378_14265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AM378_14270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM378_14275	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AM378_14280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM378_14285	COG0750	zinc metalloprotease
AM378_14290	COG0575	Belongs to the CDS family
AM378_14295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM378_14300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM378_14305	COG0233	cytoplasmic translational termination
AM378_14310	COG0528	UMP kinase activity
AM378_14320	COG0052	Belongs to the universal ribosomal protein uS2 family
AM378_14325	COG0024	Methionine aminopeptidase
AM378_14330	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AM378_14350	COG0564	pseudouridine synthase activity
AM378_14355	COG4953	penicillin-binding protein 1C
AM378_14360	COG2373	Large extracellular alpha-helical protein
AM378_14365	COG3098	single-species biofilm formation
AM378_14370	COG2814	Major facilitator Superfamily
AM378_14385	COG1611	Belongs to the LOG family
AM378_14390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM378_14395	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AM378_14400	COG2363	Small membrane protein
AM378_14405	COG0583	DNA-binding transcription factor activity
AM378_14415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM378_14420	COG2166	iron-sulfur cluster assembly
AM378_14425	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM378_14430	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AM378_14450	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM378_14455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AM378_14455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM378_14460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM378_14465	COG1074	ATP-dependent DNA helicase activity
AM378_14470	COG1025	Belongs to the peptidase M16 family
AM378_14475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM378_14495	COG2165	general secretion pathway protein
AM378_14500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AM378_14505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AM378_14515	COG0494	nUDIX hydrolase
AM378_14520	COG3066	DNA modification
AM378_14525	COG0861	Integral membrane protein TerC family
AM378_14535	COG0667	Aldo Keto reductase
AM378_14540	COG0477	Major facilitator Superfamily
AM378_14545	COG0318	PFAM AMP-dependent synthetase and ligase
AM378_14545	COG0204	Acyl-transferase
AM378_14560	COG1609	Transcriptional regulator
AM378_14575	COG0019	diaminopimelate decarboxylase activity
AM378_14580	COG0583	DNA-binding transcription factor activity
AM378_14585	COG0583	DNA-binding transcription factor activity
AM378_14605	COG4178	(ABC) transporter
AM378_14615	COG3716	PTS system mannose fructose sorbose family IID component
AM378_14620	COG3715	PTS system
AM378_14625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_14635	COG1349	DNA-binding transcription factor activity
AM378_14640	COG2807	transmembrane transport
AM378_14650	COG4615	Cyclic peptide transporter
AM378_14655	COG0582	viral genome integration into host DNA
AM378_14660	COG2197	response regulator
AM378_14665	COG2197	response regulator
AM378_14670	COG3539	Fimbrial protein
AM378_14685	COG3121	Chaperone
AM378_14695	COG0582	viral genome integration into host DNA
AM378_14705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM378_14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM378_14750	COG1620	l-lactate permease
AM378_14755	COG1304	FMN binding
AM378_14775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM378_14780	COG1309	transcriptional regulator
AM378_14785	COG5265	(ABC) transporter
AM378_14790	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AM378_14795	COG4942	peptidase
AM378_14800	COG3247	response to pH
AM378_14820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM378_14830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM378_14840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AM378_14850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM378_14855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM378_14860	COG4974	Belongs to the 'phage' integrase family
AM378_14865	COG0716	FMN binding
AM378_14870	COG4452	Inner membrane protein CreD
AM378_14875	COG2205	protein histidine kinase activity
AM378_14880	COG0745	RESPONSE REGULATOR receiver
AM378_14890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM378_14895	COG0354	folic acid binding
AM378_14905	COG1272	protein, Hemolysin III
AM378_14925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_14930	COG1940	carbohydrate kinase activity
AM378_14935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM378_14940	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_14945	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_14950	COG1129	ABC transporter
AM378_14960	COG1349	DNA-binding transcription factor activity
AM378_15000	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_15015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM378_15015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM378_15020	COG0509	glycine decarboxylation via glycine cleavage system
AM378_15025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AM378_15030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM378_15035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM378_15040	COG0006	proline dipeptidase activity
AM378_15045	COG3079	Belongs to the UPF0149 family
AM378_15050	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AM378_15060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM378_15065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM378_15070	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AM378_15075	COG0583	DNA-binding transcription factor activity
AM378_15085	COG1279	arginine transmembrane transporter activity
AM378_15090	COG1414	Transcriptional regulator
AM378_15095	COG1129	ABC transporter
AM378_15100	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_15120	COG2731	YhcH YjgK YiaL family protein
AM378_15130	COG1070	Carbohydrate kinase
AM378_15135	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AM378_15140	COG3623	hexulose-6-phosphate isomerase
AM378_15145	COG0235	Class ii aldolase
AM378_15150	COG0564	pseudouridine synthase activity
AM378_15155	COG3122	Protein conserved in bacteria
AM378_15170	COG2271	Major facilitator Superfamily
AM378_15185	COG0191	fructose-bisphosphate aldolase activity
AM378_15190	COG0126	phosphoglycerate kinase activity
AM378_15195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM378_15200	COG3842	ATPase activity
AM378_15205	COG1175	transmembrane transport
AM378_15220	COG1114	Component of the transport system for branched-chain amino acids
AM378_15225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM378_15230	COG0501	Belongs to the peptidase M48B family
AM378_15245	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AM378_15250	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_15255	COG2267	carboxylic ester hydrolase activity
AM378_15280	COG1414	Transcriptional regulator
AM378_15285	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_15300	COG2146	nitrite reductase [NAD(P)H] activity
AM378_15305	COG2271	Major facilitator Superfamily
AM378_15315	COG0010	Belongs to the arginase family
AM378_15320	COG1166	arginine decarboxylase activity
AM378_15330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AM378_15345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM378_15350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM378_15355	COG1120	ATPase activity
AM378_15360	COG4774	siderophore transport
AM378_15365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM378_15370	COG1643	Atp-dependent helicase
AM378_15375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AM378_15380	COG1489	DNA binding
AM378_15390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM378_15395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM378_15400	COG0617	tRNA 3'-terminal CCA addition
AM378_15405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM378_15410	COG0642	Histidine kinase
AM378_15415	COG0745	RESPONSE REGULATOR receiver
AM378_15420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AM378_15425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AM378_15430	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AM378_15435	COG0726	polysaccharide deacetylase
AM378_15440	COG0842	Transport permease protein
AM378_15445	COG1131	(ABC) transporter
AM378_15450	COG0288	reversible hydration of carbon dioxide
AM378_15460	COG2132	Multicopper oxidase
AM378_15470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AM378_15475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AM378_15480	COG3112	Uncharacterised protein family (UPF0231)
AM378_15490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM378_15495	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM378_15500	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AM378_15505	COG2186	Transcriptional regulator
AM378_15510	COG1113	amino acid transport
AM378_15515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM378_15515	COG2010	Cytochrome c
AM378_15525	COG2010	Cytochrome c
AM378_15525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM378_15535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AM378_15540	COG3708	Transcriptional regulator
AM378_15540	COG2207	Transcriptional regulator
AM378_15550	COG3091	SprT-like family
AM378_15555	COG2356	endonuclease I
AM378_15560	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM378_15565	COG0189	ligase activity
AM378_15570	COG1678	Uncharacterized ACR, COG1678
AM378_15575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM378_15580	COG2805	Type II/IV secretion system protein
AM378_15585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AM378_15590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AM378_15595	COG0762	integral membrane protein
AM378_15600	COG1872	DUF167
AM378_15610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM378_15625	COG2066	Belongs to the glutaminase family
AM378_15630	COG3171	Protein conserved in bacteria
AM378_15635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM378_15645	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AM378_15650	COG0741	lytic transglycosylase activity
AM378_15655	COG1982	Orn Lys Arg decarboxylase major
AM378_15680	COG3539	Fimbrial protein
AM378_15690	COG3121	Chaperone
AM378_15700	COG3188	usher protein
AM378_15740	COG2819	hydrolase of the alpha beta superfamily
AM378_15745	COG0454	-acetyltransferase
AM378_15785	COG4772	TonB-dependent receptor
AM378_15790	COG0583	DNA-binding transcription factor activity
AM378_15795	COG1473	amidohydrolase
AM378_15800	COG1473	amidohydrolase
AM378_15805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AM378_15835	COG0848	biopolymer transport protein
AM378_15840	COG0811	peptide transport
AM378_15850	COG0586	Pfam SNARE associated Golgi protein
AM378_15855	COG2207	Transcriptional regulator
AM378_15860	COG1979	alcohol dehydrogenase
AM378_15865	COG0656	L-ascorbic acid biosynthetic process
AM378_15870	COG0741	lytic transglycosylase activity
AM378_15890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_15895	COG2211	Major facilitator Superfamily
AM378_15900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AM378_15905	COG0583	DNA-binding transcription factor activity
AM378_15910	COG2132	Multicopper oxidase
AM378_15915	COG0204	Acyl-transferase
AM378_15925	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM378_15930	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM378_15935	COG0583	DNA-binding transcription factor activity
AM378_15940	COG0187	DNA topoisomerase II activity
AM378_15945	COG3150	esterase
AM378_15950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM378_15955	COG3151	Protein conserved in bacteria
AM378_15960	COG0494	nUDIX hydrolase
AM378_15965	COG1538	Outer membrane efflux protein
AM378_15975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM378_15975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_15975	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AM378_15980	COG1461	Dihydroxyacetone kinase
AM378_15985	COG2376	Dihydroxyacetone kinase
AM378_15995	COG5463	Belongs to the UPF0441 family
AM378_16000	COG0754	glutathionylspermidine amidase activity
AM378_16005	COG3384	dioxygenase
AM378_16015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM378_16025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AM378_16025	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AM378_16030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AM378_16035	COG3025	triphosphatase activity
AM378_16040	COG4991	sh3 domain protein
AM378_16045	COG0617	tRNA 3'-terminal CCA addition
AM378_16050	COG1968	undecaprenyl-diphosphatase activity
AM378_16055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM378_16060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AM378_16065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AM378_16075	COG0358	DNA primase activity
AM378_16080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM378_16140	COG5301	cellulose 1,4-beta-cellobiosidase activity
AM378_16230	COG4695	Portal protein
AM378_16270	COG5002	protein histidine kinase activity
AM378_16270	COG2176	DNA-directed DNA polymerase activity
AM378_16315	COG4974	Belongs to the 'phage' integrase family
AM378_16330	COG0625	glutathione transferase activity
AM378_16340	COG1012	belongs to the aldehyde dehydrogenase family
AM378_16345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM378_16355	COG0488	(ABC) transporter
AM378_16360	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM378_16360	COG1902	pentaerythritol trinitrate reductase activity
AM378_16365	COG2813	Specifically methylates the guanine in position
AM378_16370	COG1451	nucleotide metabolic process
AM378_16375	COG0673	inositol 2-dehydrogenase activity
AM378_16385	COG0861	Integral membrane protein TerC family
AM378_16390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AM378_16395	COG2721	sulfolactate sulfo-lyase activity
AM378_16400	COG1904	glucuronate isomerase
AM378_16405	COG2271	Major facilitator Superfamily
AM378_16420	COG0586	Pfam SNARE associated Golgi protein
AM378_16425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM378_16435	COG4575	ribosome binding
AM378_16440	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AM378_16450	COG2259	Doxx family
AM378_16455	COG0435	Glutathione S-transferase
AM378_16460	COG0583	DNA-binding transcription factor activity
AM378_16465	COG1741	Belongs to the pirin family
AM378_16475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM378_16480	COG3107	peptidoglycan biosynthetic process
AM378_16485	COG0792	nuclease activity
AM378_16490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AM378_16495	COG2823	Periplasmic or secreted lipoprotein
AM378_16505	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AM378_16510	COG0784	Response regulator, receiver
AM378_16510	COG2198	Histidine kinase
AM378_16510	COG5002	protein histidine kinase activity
AM378_16520	COG1242	4 iron, 4 sulfur cluster binding
AM378_16530	COG0069	glutamate synthase activity
AM378_16530	COG0067	glutamate synthase
AM378_16530	COG0070	glutamate synthase
AM378_16535	COG0493	'glutamate synthase
AM378_16545	COG2969	positive regulation of protein catabolic process
AM378_16550	COG0625	glutathione transferase activity
AM378_16560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM378_16565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AM378_16570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM378_16575	COG3105	Protein conserved in bacteria
AM378_16580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM378_16585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM378_16590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM378_16595	COG5007	Belongs to the BolA IbaG family
AM378_16600	COG3113	response to antibiotic
AM378_16605	COG2854	intermembrane phospholipid transfer
AM378_16610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM378_16615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM378_16620	COG1127	ABC transporter
AM378_16625	COG0530	calcium, potassium:sodium antiporter activity
AM378_16630	COG0517	IMP dehydrogenase activity
AM378_16630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AM378_16635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM378_16640	COG3117	lipopolysaccharide transmembrane transporter activity
AM378_16645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AM378_16650	COG1137	ATPase activity
AM378_16655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AM378_16665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_16670	COG1660	Displays ATPase and GTPase activities
AM378_16675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_16680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_16680	COG3711	transcriptional antiterminator
AM378_16700	COG3964	amidohydrolase
AM378_16730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM378_16740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM378_16750	COG2207	Transcriptional regulator
AM378_16755	COG3783	Cytochrome b(562)
AM378_16760	COG0312	modulator of DNA gyrase
AM378_16775	COG3028	Belongs to the UPF0307 family
AM378_16780	COG2732	(Barnase) inhibitor
AM378_16790	COG1289	transmembrane transporter activity
AM378_16795	COG1566	PFAM secretion protein HlyD family protein
AM378_16805	COG0583	DNA-binding transcription factor activity
AM378_16830	COG2134	cdp-diacylglycerol pyrophosphatase
AM378_16835	COG0312	modulator of DNA gyrase
AM378_16840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM378_16845	COG3164	Protein of unknown function
AM378_16850	COG1530	ribonuclease E activity
AM378_16860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AM378_16865	COG1792	Involved in formation and maintenance of cell shape
AM378_16870	COG1077	Cell shape determining protein MreB Mrl
AM378_16875	COG2200	EAL domain
AM378_16875	COG2199	diguanylate cyclase activity
AM378_16880	COG0604	alcohol dehydrogenase
AM378_16885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM378_16890	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AM378_16895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AM378_16900	COG0511	ligase activity, forming carbon-carbon bonds
AM378_16905	COG0439	Biotin carboxylase
AM378_16910	COG3924	membrane
AM378_16915	COG4145	pantothenate transmembrane transporter activity
AM378_16920	COG2264	protein methyltransferase activity
AM378_16945	COG1560	Kdo2-lipid A biosynthetic process
AM378_16950	COG0504	CTP synthase activity
AM378_16965	COG1380	Effector of murein hydrolase LrgA
AM378_16970	COG0583	DNA-binding transcription factor activity
AM378_16975	COG0025	NhaP-type Na H and K H
AM378_16980	COG2252	PERMEase
AM378_16990	COG0625	glutathione transferase activity
AM378_17005	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_17020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM378_17025	COG1064	alcohol dehydrogenase
AM378_17030	COG0110	maltose O-acetyltransferase activity
AM378_17035	COG2315	Protein conserved in bacteria
AM378_17040	COG0432	Pfam Uncharacterised protein family UPF0047
AM378_17045	COG1448	Aminotransferase
AM378_17050	COG1522	sequence-specific DNA binding
AM378_17060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM378_17065	COG0305	Participates in initiation and elongation during chromosome replication
AM378_17070	COG0604	alcohol dehydrogenase
AM378_17080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM378_17090	COG0735	belongs to the Fur family
AM378_17095	COG3237	CsbD-like
AM378_17100	COG0534	Mate efflux family protein
AM378_17105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM378_17110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AM378_17115	COG2937	Belongs to the GPAT DAPAT family
AM378_17120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM378_17125	COG3161	chorismate lyase activity
AM378_17130	COG0477	Major facilitator Superfamily
AM378_17135	COG1609	Transcriptional regulator
AM378_17150	COG4580	involved in the transport of maltose and maltodextrins
AM378_17160	COG0366	Alpha amylase catalytic
AM378_17165	COG2182	Extracellular solute-binding protein
AM378_17170	COG1175	transmembrane transport
AM378_17175	COG3833	ABC-type maltose transport systems, permease component
AM378_17180	COG3223	Belongs to the PsiE family
AM378_17190	COG0166	Belongs to the GPI family
AM378_17200	COG0527	aspartate kinase activity
AM378_17220	COG1283	sodium-dependent phosphate transmembrane transporter activity
AM378_17225	COG3842	ATPase activity
AM378_17250	COG2188	Transcriptional regulator
AM378_17255	COG1410	methionine synthase
AM378_17255	COG0646	methionine synthase
AM378_17260	COG1414	Transcriptional regulator
AM378_17265	COG3265	gluconokinase activity
AM378_17270	COG2610	gluconate transmembrane transporter activity
AM378_17275	COG0129	dihydroxy-acid dehydratase activity
AM378_17280	COG0800	Aldolase
AM378_17285	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AM378_17295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM378_17300	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AM378_17335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM378_17340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AM378_17345	COG0009	L-threonylcarbamoyladenylate synthase
AM378_17350	COG0551	DNA topoisomerase type I activity
AM378_17355	COG2922	Belongs to the Smg family
AM378_17360	COG0758	DNA mediated transformation
AM378_17365	COG0242	peptide deformylase activity
AM378_17370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM378_17375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM378_17375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM378_17380	COG0569	domain protein
AM378_17385	COG1970	mechanosensitive ion channel activity
AM378_17390	COG3036	rescue of stalled ribosome
AM378_17395	COG0789	Transcriptional regulator
AM378_17405	COG0203	ribosomal protein L17
AM378_17410	COG0202	RNA polymerase activity
AM378_17415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AM378_17420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM378_17425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AM378_17430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM378_17435	COG0201	protein transport
AM378_17445	COG1841	ribosomal large subunit assembly
AM378_17450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AM378_17455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AM378_17460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AM378_17485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AM378_17500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM378_17505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM378_17515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM378_17525	COG0089	rRNA binding
AM378_17530	COG0088	Forms part of the polypeptide exit tunnel
AM378_17535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AM378_17540	COG0051	transcription antitermination factor activity, RNA binding
AM378_17555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM378_17565	COG0049	tRNA binding
AM378_17570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AM378_17575	COG2168	tRNA wobble position uridine thiolation
AM378_17580	COG2923	Belongs to the DsrF TusC family
AM378_17585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM378_17590	COG2964	Protein conserved in bacteria
AM378_17595	COG0545	Peptidyl-prolyl cis-trans isomerase
AM378_17600	COG2900	Belongs to the SlyX family
AM378_17605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AM378_17610	COG1757	Na H antiporter
AM378_17615	COG1609	Transcriptional regulator
AM378_17620	COG1047	Peptidyl-prolyl cis-trans
AM378_17625	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AM378_17635	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM378_17640	COG0488	(ABC) transporter
AM378_17645	COG2175	clavaminate synthase activity
AM378_17650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM378_17660	COG4521	taurine ABC transporter
AM378_17675	COG0429	hydrolase of the alpha beta-hydrolase fold
AM378_17680	COG3089	Belongs to the UPF0270 family
AM378_17685	COG3954	Phosphoribulokinase
AM378_17690	COG1765	OsmC-like protein
AM378_17695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM378_17700	COG1289	transmembrane transporter activity
AM378_17715	COG0433	COG0433 Predicted ATPase
AM378_17735	COG3275	phosphorelay sensor kinase activity
AM378_17740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM378_17750	COG1447	Phosphotransferase system cellobiose-specific component IIA
AM378_17755	COG1486	melibiose metabolic process
AM378_17760	COG1609	Transcriptional regulator
AM378_17765	COG0738	Major facilitator superfamily
AM378_17770	COG0402	S-adenosylhomocysteine deaminase activity
AM378_17775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM378_17780	COG2146	nitrite reductase [NAD(P)H] activity
AM378_17790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM378_17790	COG1648	precorrin-2 dehydrogenase activity
AM378_17795	COG0180	Tryptophanyl-tRNA synthetase
AM378_17800	COG0546	phosphoglycolate phosphatase activity
AM378_17820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AM378_17825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM378_17830	COG4796	Type ii and iii secretion system protein
AM378_17855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AM378_17860	COG0494	nUDIX hydrolase
AM378_17870	COG1011	Hydrolase
AM378_17875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM378_17880	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AM378_17905	COG0745	RESPONSE REGULATOR receiver
AM378_17915	COG0484	heat shock protein binding
AM378_17920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM378_17925	COG2183	response to ionizing radiation
AM378_17930	COG1918	ferrous iron import across plasma membrane
AM378_17955	COG1040	competence protein
AM378_17960	COG0316	Belongs to the HesB IscA family
AM378_17960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AM378_17965	COG1640	4-alpha-glucanotransferase
AM378_17970	COG0058	SHG alpha-glucan phosphorylase activity
AM378_17975	COG2909	trisaccharide binding
AM378_18000	COG3414	Phosphotransferase system galactitol-specific IIB component
AM378_18020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM378_18025	COG0705	Rhomboid family
AM378_18030	COG1349	DNA-binding transcription factor activity
AM378_18035	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM378_18040	COG0058	SHG alpha-glucan phosphorylase activity
AM378_18045	COG0297	glycogen (starch) synthase activity
AM378_18050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AM378_18055	COG1523	belongs to the glycosyl hydrolase 13 family
AM378_18060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AM378_18065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM378_18070	COG2095	MarC family integral membrane protein
AM378_18075	COG3265	gluconokinase activity
AM378_18080	COG2610	gluconate transmembrane transporter activity
AM378_18085	COG1609	Transcriptional regulator
AM378_18090	COG1741	Belongs to the pirin family
AM378_18095	COG1247	-acetyltransferase
AM378_18100	COG3191	aminopeptidase activity
AM378_18105	COG1082	Xylose isomerase domain protein TIM barrel
AM378_18110	COG1082	Xylose isomerase domain protein TIM barrel
AM378_18115	COG0673	inositol 2-dehydrogenase activity
AM378_18120	COG3962	Belongs to the TPP enzyme family
AM378_18125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_18145	COG3718	enzyme involved in inositol metabolism
AM378_18155	COG0477	Major facilitator Superfamily
AM378_18155	COG2814	Major facilitator Superfamily
AM378_18165	COG0390	transport system, permease component
AM378_18170	COG4619	ABC transporter
AM378_18190	COG3188	usher protein
AM378_18215	COG2197	response regulator
AM378_18225	COG2130	NADP-dependent
AM378_18250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM378_18265	COG0697	spore germination
AM378_18285	COG0346	lactoylglutathione lyase activity
AM378_18290	COG2081	HI0933 family
AM378_18295	COG0306	phosphate transporter
AM378_18315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM378_18315	COG0475	glutathione-regulated potassium exporter activity
AM378_18325	COG0583	DNA-binding transcription factor activity
AM378_18330	COG0589	response to stress
AM378_18345	COG1129	ABC transporter
AM378_18350	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_18355	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_18370	COG0742	ribosomal rna small subunit methyltransferase
AM378_18375	COG0339	signal peptide processing
AM378_18400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AM378_18405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM378_18415	COG0784	Response regulator, receiver
AM378_18415	COG2205	protein histidine kinase activity
AM378_18440	COG5441	Belongs to the UPF0261 family
AM378_18445	COG3678	ATP-independent chaperone mediated protein folding
AM378_18450	COG5001	Diguanylate cyclase
AM378_18455	COG1024	Enoyl-CoA hydratase
AM378_18460	COG1295	ribonuclease BN
AM378_18465	COG0477	Major facilitator Superfamily
AM378_18470	COG2134	cdp-diacylglycerol pyrophosphatase
AM378_18475	COG2982	Protein involved in outer membrane biogenesis
AM378_18480	COG2200	EAL domain
AM378_18485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_18495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AM378_18500	COG0583	DNA-binding transcription factor activity
AM378_18515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM378_18520	COG0129	dihydroxy-acid dehydratase activity
AM378_18525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM378_18530	COG3978	acetolactate synthase activity
AM378_18555	COG3085	chromosome segregation
AM378_18560	COG0583	DNA-binding transcription factor activity
AM378_18600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM378_18605	COG4206	TonB-dependent receptor
AM378_18610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM378_18625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM378_18635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM378_18635	COG0678	peroxiredoxin activity
AM378_18640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM378_18650	COG0165	Argininosuccinate lyase
AM378_18655	COG0137	argininosuccinate synthase activity
AM378_18660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM378_18665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AM378_18675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AM378_18680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM378_18685	COG0460	homoserine dehydrogenase
AM378_18685	COG0527	aspartate kinase activity
AM378_18690	COG0626	cystathionine gamma-synthase activity
AM378_18695	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AM378_18700	COG0254	rRNA binding
AM378_18705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM378_18710	COG1609	Transcriptional regulator
AM378_18715	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM378_18720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AM378_18725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AM378_18730	COG1575	Belongs to the MenA family. Type 1 subfamily
AM378_18735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM378_18740	COG3074	FtsZ-dependent cytokinesis
AM378_18755	COG1494	fructose-1,6-bisphosphatase
AM378_18760	COG2814	Major facilitator Superfamily
AM378_18775	COG3152	Membrane
AM378_18785	COG0149	triose-phosphate isomerase activity
AM378_18790	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM378_18795	COG0205	6-phosphofructokinase activity
AM378_18800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AM378_18805	COG3678	ATP-independent chaperone mediated protein folding
AM378_18810	COG0745	RESPONSE REGULATOR receiver
AM378_18815	COG2205	protein histidine kinase activity
AM378_18820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM378_18835	COG1045	serine acetyltransferase
AM378_18850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM378_18855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM378_18860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AM378_18865	COG4942	peptidase
AM378_18870	COG2861	carbohydrate metabolic process
AM378_18875	COG1063	alcohol dehydrogenase
AM378_18880	COG0156	8-amino-7-oxononanoate synthase activity
AM378_18885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_18890	COG0859	PFAM glycosyl transferase family 9
AM378_18895	COG0859	PFAM glycosyl transferase family 9
AM378_18900	COG0438	transferase activity, transferring glycosyl groups
AM378_18905	COG3307	-O-antigen
AM378_18910	COG1442	glycosyl transferase family 8
AM378_18910	COG1216	Glycosyl transferase, family 2
AM378_18925	COG0859	PFAM glycosyl transferase family 9
AM378_18930	COG0438	transferase activity, transferring glycosyl groups
AM378_18935	COG0438	transferase activity, transferring glycosyl groups
AM378_18945	COG1519	Transferase
AM378_18965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM378_18970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM378_18975	COG2003	Belongs to the UPF0758 family
AM378_18980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM378_18985	COG0756	dUTP diphosphatase activity
AM378_18990	COG1309	transcriptional regulator
AM378_18995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM378_19000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AM378_19005	COG1561	YicC-like family, N-terminal region
AM378_19015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM378_19025	COG2860	membrane
AM378_19030	COG0194	GDP metabolic process
AM378_19035	COG1758	RNA polymerase activity
AM378_19040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM378_19045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM378_19050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM378_19055	COG0786	glutamate:sodium symporter activity
AM378_19060	COG2233	PERMEase
AM378_19065	COG2982	Protein involved in outer membrane biogenesis
AM378_19070	COG0456	acetyltransferase
AM378_19075	COG1490	D-aminoacyl-tRNA deacylase activity
AM378_19080	COG1295	ribonuclease BN
AM378_19085	COG1011	Hydrolase
AM378_19095	COG0174	glutamine synthetase
AM378_19100	COG3852	Histidine kinase
AM378_19110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM378_19120	COG3078	GTPase activator activity
AM378_19130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AM378_19135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM378_19135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM378_19140	COG0204	Acyl-transferase
AM378_19145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM378_19150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM378_19155	COG3084	Protein conserved in bacteria
AM378_19160	COG0746	molybdenum cofactor guanylyltransferase activity
AM378_19165	COG1763	Mo-molybdopterin cofactor biosynthetic process
AM378_19190	COG2186	Transcriptional regulator
AM378_19195	COG0477	Major facilitator Superfamily
AM378_19200	COG1609	Transcriptional regulator
AM378_19205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_19210	COG1879	ABC-type sugar transport system periplasmic component
AM378_19215	COG1172	Belongs to the binding-protein-dependent transport system permease family
AM378_19220	COG1129	ABC transporter
AM378_19225	COG1869	D-ribose catabolic process
AM378_19230	COG3158	transport of potassium into the cell
AM378_19235	COG0714	Associated with various cellular activities
AM378_19240	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AM378_19245	COG2502	aspartate--ammonia ligase
AM378_19250	COG1522	sequence-specific DNA binding
AM378_19255	COG0716	FMN binding
AM378_19260	COG0445	tRNA wobble uridine modification
AM378_19265	COG0357	Ribosomal RNA small subunit methyltransferase G
AM378_19270	COG3312	ion transport
AM378_19285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM378_19290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM378_19295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AM378_19300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM378_19305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AM378_19310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM378_19315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM378_19320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM378_19325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM378_19330	COG0573	inorganic phosphate transmembrane transporter activity
AM378_19335	COG0581	inorganic phosphate transmembrane transporter activity
AM378_19345	COG0704	Plays a role in the regulation of phosphate uptake
AM378_19350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM378_19355	COG0765	amino acid transport
AM378_19360	COG0765	amino acid transport
AM378_19365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM378_19370	COG0494	nUDIX hydrolase
AM378_19375	COG2252	PERMEase
AM378_19385	COG0431	NADPH-dependent FMN reductase
AM378_19390	COG2091	lysine biosynthetic process via aminoadipic acid
AM378_19400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AM378_19405	COG0706	membrane insertase activity
AM378_19410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM378_19415	COG0594	ribonuclease P activity
AM378_19425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM378_19430	COG0592	DNA-directed DNA polymerase activity
AM378_19435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM378_19440	COG0187	DNA topoisomerase II activity
AM378_19445	COG0561	phosphatase activity
AM378_19450	COG2423	ornithine cyclodeaminase activity
AM378_19465	COG0823	Involved in the tonB-independent uptake of proteins
AM378_19470	COG5645	(Lipo)protein
AM378_19475	COG0071	Belongs to the small heat shock protein (HSP20) family
AM378_19480	COG0071	Belongs to the small heat shock protein (HSP20) family
AM378_19485	COG2985	domain, Protein
AM378_19500	COG3977	Valine--pyruvate aminotransferase
AM378_19505	COG0366	Alpha amylase catalytic
AM378_19510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM378_19515	COG2814	Major facilitator Superfamily
AM378_19520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM378_19530	COG1609	Transcriptional regulator
AM378_19535	COG2885	chlorophyll binding
AM378_19545	COG2818	Glycosylase
AM378_19555	COG0752	glycyl-tRNA synthetase alpha subunit
AM378_19560	COG0751	glycine-tRNA ligase activity
AM378_19585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM378_19585	COG2213	PTS system mannitol-specific
AM378_19590	COG0246	Mannitol dehydrogenase
AM378_19595	COG3722	fumarate hydratase activity
AM378_19605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM378_19620	COG2258	MOSC domain
AM378_19625	COG0840	transmembrane signaling receptor activity
AM378_19630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM378_19635	COG0243	molybdopterin cofactor binding
AM378_19635	COG3383	formate dehydrogenase (NAD+) activity
AM378_19640	COG0243	molybdopterin cofactor binding
AM378_19640	COG3383	formate dehydrogenase (NAD+) activity
AM378_19645	COG0437	4 iron, 4 sulfur cluster binding
AM378_19650	COG2864	formate dehydrogenase
AM378_19655	COG3058	Necessary for formate dehydrogenase activity
AM378_19665	COG0625	glutathione transferase activity
AM378_19670	COG1921	L-seryl-tRNASec selenium transferase activity
AM378_19675	COG3276	selenocysteine insertion sequence binding
AM378_19690	COG0583	DNA-binding transcription factor activity
AM378_19705	COG3274	enterobacterial common antigen metabolic process
AM378_19715	COG1335	isochorismatase
AM378_19720	COG0402	S-adenosylhomocysteine deaminase activity
AM378_19735	COG0583	DNA-binding transcription factor activity
AM378_19740	COG2807	transmembrane transport
AM378_19795	COG2814	Major facilitator Superfamily
AM378_19825	COG1846	Transcriptional regulator
AM378_19830	COG1764	response to oxidative stress
AM378_19835	COG2194	sulfuric ester hydrolase activity
AM378_19840	COG2197	response regulator
AM378_19850	COG2271	Major facilitator Superfamily
AM378_19880	COG0747	negative chemotaxis
AM378_19885	COG0601	transmembrane transport
AM378_19890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM378_19895	COG0444	Belongs to the ABC transporter superfamily
AM378_19900	COG4608	Belongs to the ABC transporter superfamily
AM378_19905	COG2194	sulfuric ester hydrolase activity
AM378_19935	COG1215	transferase activity, transferring glycosyl groups
AM378_19940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AM378_19945	COG0457	Tetratricopeptide repeat
AM378_19945	COG3118	belongs to the thioredoxin family
AM378_19950	COG2200	EAL domain
AM378_19950	COG2199	diguanylate cyclase activity
AM378_19955	COG1301	dicarboxylic acid transport
AM378_19960	COG0612	Peptidase, M16
AM378_19965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM378_19975	COG0248	Ppx GppA phosphatase
AM378_19985	COG3118	belongs to the thioredoxin family
AM378_19990	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AM378_19995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM378_20005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AM378_20010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM378_20015	COG1088	dTDP-glucose 4,6-dehydratase activity
AM378_20020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AM378_20025	COG0456	acetyltransferase
AM378_20030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM378_20035	COG2244	polysaccharide biosynthetic process
AM378_20040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM378_20050	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AM378_20055	COG1113	amino acid transport
AM378_20090	COG3071	HemY protein
AM378_20095	COG2959	enzyme of heme biosynthesis
AM378_20105	COG0181	hydroxymethylbilane synthase activity
AM378_20110	COG3072	Adenylate cyclase
AM378_20115	COG1965	Belongs to the frataxin family
AM378_20120	COG5567	small periplasmic lipoprotein
AM378_20125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AM378_20130	COG3159	Protein conserved in bacteria
AM378_20140	COG1011	Hydrolase
AM378_20145	COG0210	DNA helicase
AM378_20160	COG0598	Magnesium transport protein CorA
AM378_20170	COG2050	protein possibly involved in aromatic compounds catabolism
AM378_20175	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AM378_20180	COG0514	ATP-dependent DNA helicase (RecQ)
AM378_20185	COG1280	lysine exporter protein (LysE YggA)
AM378_20190	COG1280	lysine exporter protein (LysE YggA)
AM378_20195	COG2267	carboxylic ester hydrolase activity
AM378_20200	COG0561	phosphatase activity
AM378_20205	COG0584	glycerophosphoryl diester phosphodiesterase
AM378_20210	COG2271	Major facilitator Superfamily
AM378_20220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM378_20230	COG0247	lactate metabolic process
AM378_20245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AM378_20250	COG0425	Belongs to the sulfur carrier protein TusA family
AM378_20265	COG2217	Heavy metal translocating P-type atpase
AM378_20280	COG3714	YhhN family
AM378_20290	COG3776	membrane
AM378_20295	COG0742	ribosomal rna small subunit methyltransferase
AM378_20300	COG0552	protein localization to endoplasmic reticulum
AM378_20300	COG0552	protein localization to endoplasmic reticulum
AM378_20305	COG2884	Cell division ATP-binding protein ftsE
AM378_20310	COG2177	Part of the ABC transporter FtsEX involved in
AM378_20330	COG0456	acetyltransferase
AM378_20340	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM378_20345	COG4177	L-phenylalanine transmembrane transporter activity
AM378_20350	COG0411	ABC transporter
AM378_20355	COG0410	ABC transporter
AM378_20360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM378_20365	COG1653	transport
AM378_20370	COG1175	transmembrane transport
AM378_20380	COG3842	ATPase activity
AM378_20385	COG0584	glycerophosphoryl diester phosphodiesterase
AM378_20405	COG0583	DNA-binding transcription factor activity
AM378_20410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM378_20415	COG0412	Dienelactone hydrolase
AM378_20420	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AM378_20430	COG0586	Pfam SNARE associated Golgi protein
AM378_20435	COG1322	Protein conserved in bacteria
AM378_20440	COG2226	methyltransferase
AM378_20445	COG3165	ubiquinone biosynthetic process from chorismate
AM378_20450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM378_20455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM378_20465	COG0805	protein transport
AM378_20470	COG0084	hydrolase, TatD family'
AM378_20500	COG0183	Belongs to the thiolase family
AM378_20505	COG1024	Enoyl-CoA hydratase
AM378_20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM378_20510	COG0006	proline dipeptidase activity
AM378_20515	COG1739	Uncharacterized protein family UPF0029
AM378_20520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM378_20550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM378_20555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AM378_20555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AM378_20560	COG1072	(Pantothenic acid kinase))
AM378_20595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM378_20600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM378_20605	COG0250	Participates in transcription elongation, termination and antitermination
AM378_20620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AM378_20630	COG0085	RNA polymerase activity
AM378_20635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM378_20650	COG5002	protein histidine kinase activity
AM378_20670	COG2022	thiamine diphosphate biosynthetic process
AM378_20675	COG2104	thiamine diphosphate biosynthetic process
AM378_20680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM378_20685	COG0352	thiamine-phosphate diphosphorylase activity
AM378_20690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AM378_20695	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AM378_20700	COG2816	NAD+ diphosphatase activity
AM378_20705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AM378_20710	COG1515	deoxyribonuclease V activity
AM378_20715	COG3068	Protein conserved in bacteria
AM378_20730	COG0151	Belongs to the GarS family
AM378_20735	COG0138	bifunctional purine biosynthesis protein purh
AM378_20765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM378_20770	COG3162	membrane
AM378_20775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM378_20780	COG1301	dicarboxylic acid transport
AM378_20785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM378_20785	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AM378_20790	COG2226	methyltransferase
AM378_20790	COG3433	isochorismatase activity
AM378_20790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM378_20795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM378_20800	COG4774	siderophore transport
AM378_20800	COG1629	transport
AM378_20805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM378_20810	COG3391	amine dehydrogenase activity
AM378_20815	COG4771	TonB-dependent receptor
AM378_20820	COG2382	esterase
AM378_20830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM378_20830	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AM378_20840	COG1169	isochorismate synthase
AM378_20845	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM378_20850	COG3433	isochorismatase activity
AM378_20850	COG1535	isochorismatase
AM378_20860	COG3647	Membrane
AM378_20875	COG1309	transcriptional regulator
AM378_20880	COG4232	protein-disulfide reductase activity
AM378_20890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AM378_20905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM378_20920	COG1509	lysine 2,3-aminomutase activity
AM378_20925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AM378_20930	COG5510	response to toxic substance
AM378_20935	COG5510	response to toxic substance
AM378_20950	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AM378_20955	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AM378_20960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM378_20965	COG1053	succinate dehydrogenase
AM378_20970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AM378_20975	COG3264	Mechanosensitive ion channel
AM378_20975	COG1511	domain protein
AM378_20980	COG0688	phosphatidylethanolamine metabolic process
AM378_20985	COG1162	GTPase activity
AM378_20990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AM378_21010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM378_21015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM378_21015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM378_21020	COG0802	atpase or kinase
AM378_21025	COG0860	N-Acetylmuramoyl-L-alanine amidase
AM378_21030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM378_21035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AM378_21045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM378_21050	COG0330	HflC and HflK could
AM378_21055	COG0330	HflC and HflK could
AM378_21060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AM378_21065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM378_21070	COG1959	2 iron, 2 sulfur cluster binding
AM378_21075	COG0557	exoribonuclease II activity
AM378_21080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM378_21085	COG1960	acyl-CoA dehydrogenase activity
AM378_21090	COG3766	membrane
AM378_21100	COG3650	response to hydrogen peroxide
AM378_21105	COG1073	alpha beta
AM378_21120	COG0360	Binds together with S18 to 16S ribosomal RNA
AM378_21135	COG0359	binds to the 23S rRNA
AM378_21145	COG3061	Opacity-associated protein A
AM378_21150	COG0545	Peptidyl-prolyl cis-trans isomerase
AM378_21160	COG0737	Belongs to the 5'-nucleotidase family
AM378_21170	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AM378_21180	COG1253	flavin adenine dinucleotide binding
AM378_21185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM378_21190	COG0729	surface antigen
AM378_21195	COG2911	Protein conserved in bacteria
AM378_21200	COG2105	PFAM AIG2 family protein
AM378_21205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM378_21215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AM378_21220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM378_21235	COG1438	arginine binding
AM378_21240	COG0039	L-malate dehydrogenase activity
AM378_21245	COG3423	Transcriptional regulator
AM378_21255	COG0142	geranyltranstransferase activity
AM378_21260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AM378_21265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AM378_21270	COG0697	spore germination
AM378_21275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AM378_21280	COG0642	Histidine kinase
AM378_21285	COG0745	RESPONSE REGULATOR receiver
AM378_21290	COG2027	D-alanyl-D-alanine carboxypeptidase
AM378_21295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM378_21300	COG1534	Rna-binding protein
AM378_21305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AM378_21310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM378_21315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM378_21320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM378_21325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM378_21340	COG0779	Required for maturation of 30S ribosomal subunits
AM378_21345	COG0195	Participates in both transcription termination and antitermination
AM378_21350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM378_21355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AM378_21360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM378_21365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AM378_21375	COG1185	polyribonucleotide nucleotidyltransferase activity
AM378_21390	COG0513	Belongs to the DEAD box helicase family
AM378_21395	COG2391	methyltransferase activity
AM378_21400	COG0425	Belongs to the sulfur carrier protein TusA family
AM378_21405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM378_21445	COG3153	acetyltransferase
AM378_21450	COG2827	Endonuclease containing a URI domain
AM378_21455	COG0531	amino acid
AM378_21460	COG1982	Orn Lys Arg decarboxylase major
AM378_21470	COG3787	Belongs to the UPF0306 family
AM378_21475	COG0702	epimerase
AM378_21480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AM378_21490	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AM378_21495	COG3454	Phosphonate metabolism
AM378_21500	COG4778	phosphonate C-P lyase system protein PhnL
AM378_21505	COG4107	phosphonate C-P lyase system protein PhnK
AM378_21510	COG3627	carbon phosphorus lyase activity
AM378_21515	COG3626	phosphonate metabolism
AM378_21520	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AM378_21525	COG3624	Phosphonate C-P lyase system protein PhnG
AM378_21530	COG2188	Transcriptional regulator
AM378_21535	COG0701	Predicted permease
AM378_21545	COG2207	Transcriptional regulator
AM378_21555	COG0602	queuosine metabolic process
AM378_21570	COG0583	DNA-binding transcription factor activity
AM378_21575	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM378_21580	COG0366	Alpha amylase catalytic
AM378_21585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AM378_21585	COG1263	PTS System
AM378_21595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM378_21600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AM378_21615	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AM378_21620	COG0540	Belongs to the ATCase OTCase family
AM378_21630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AM378_21635	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AM378_21645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AM378_21650	COG0456	acetyltransferase
AM378_21660	COG2927	DNA polymerase III (CHI subunit)
AM378_21665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM378_21670	COG0795	lipopolysaccharide-transporting ATPase activity
AM378_21675	COG0795	lipopolysaccharide-transporting ATPase activity
AM378_21700	COG0738	Major facilitator superfamily
AM378_21720	COG2610	gluconate transmembrane transporter activity
AM378_21725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM378_21730	COG1349	DNA-binding transcription factor activity
AM378_21740	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AM378_21765	COG1196	nuclear chromosome segregation
AM378_21805	COG2723	6-phospho-beta-galactosidase activity
AM378_21825	COG0523	cobalamin synthesis protein
AM378_21830	COG2879	small protein
AM378_21835	COG1966	Carbon starvation protein
AM378_21840	COG0583	DNA-binding transcription factor activity
AM378_21860	COG1116	anion transmembrane transporter activity
AM378_21870	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AM378_21880	COG0174	glutamine synthetase
AM378_21900	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AM378_21910	COG0583	DNA-binding transcription factor activity
AM378_21915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM378_21930	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM378_21935	COG2610	gluconate transmembrane transporter activity
AM378_21940	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_21950	COG2207	Transcriptional regulator
AM378_21960	COG3708	Transcriptional regulator
AM378_21960	COG2207	Transcriptional regulator
AM378_21965	COG1376	ErfK ybiS ycfS ynhG family protein
AM378_22000	COG0811	peptide transport
AM378_22035	COG1454	alcohol dehydrogenase
AM378_22045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM378_22055	COG2267	carboxylic ester hydrolase activity
AM378_22085	COG1113	amino acid transport
AM378_22105	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_22110	COG1846	Transcriptional regulator
AM378_22130	COG1012	belongs to the aldehyde dehydrogenase family
AM378_22145	COG3971	2-oxopent-4-enoate hydratase activity
AM378_22165	COG2368	4-hydroxyphenylacetate
AM378_22170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM378_22175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AM378_22180	COG2186	Transcriptional regulator
AM378_22185	COG1028	Short-chain dehydrogenase reductase Sdr
AM378_22190	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM378_22195	COG4948	Mandelate Racemase Muconate Lactonizing
AM378_22200	COG3618	amidohydrolase
AM378_22210	COG3254	rhamnose metabolic process
AM378_22215	COG0738	Major facilitator superfamily
AM378_22235	COG1309	transcriptional regulator
AM378_22240	COG3706	GGDEF domain
AM378_22270	COG0667	Aldo Keto reductase
AM378_22275	COG2813	Specifically methylates the guanine in position
AM378_22280	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AM378_22290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM378_22295	COG2823	Periplasmic or secreted lipoprotein
AM378_22300	COG5487	UPF0391 membrane protein
AM378_22305	COG3237	CsbD-like
AM378_22310	COG4667	esterase of the alpha-beta hydrolase superfamily
AM378_22315	COG0084	hydrolase, TatD family'
AM378_22320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AM378_22325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AM378_22335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AM378_22340	COG0813	purine-nucleoside phosphorylase activity
AM378_22345	COG3550	peptidyl-serine autophosphorylation
AM378_22350	COG3726	membrane protein affecting hemolysin expression
AM378_22355	COG0560	Phosphoserine phosphatase
AM378_22385	COG2130	NADP-dependent
AM378_22400	COG0488	(ABC) transporter
AM378_22405	COG2885	chlorophyll binding
AM378_22410	COG2199	diguanylate cyclase activity
AM378_22420	COG0741	lytic transglycosylase activity
AM378_22425	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AM378_22430	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AM378_22435	COG0406	alpha-ribazole phosphatase activity
AM378_22440	COG3708	Transcriptional regulator
AM378_22440	COG2207	Transcriptional regulator
AM378_22445	COG3045	CreA protein
AM378_22450	COG0745	RESPONSE REGULATOR receiver
AM378_22480	COG3022	response to hydroperoxide
AM378_22485	COG1115	amino acid carrier protein
AM378_22490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM378_22495	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM378_22505	COG1584	GPR1 FUN34 yaaH family protein
AM378_22510	COG0443	Heat shock 70 kDa protein
AM378_22515	COG0484	heat shock protein binding
AM378_22520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM378_22525	COG0583	DNA-binding transcription factor activity
AM378_22530	COG0268	Binds directly to 16S ribosomal RNA
AM378_22540	COG0196	riboflavin kinase activity
AM378_22545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM378_22550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AM378_22555	COG1047	Peptidyl-prolyl cis-trans
AM378_22560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AM378_22585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AM378_22590	COG0505	Belongs to the CarA family
AM378_22595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AM378_22615	COG2966	Psort location CytoplasmicMembrane, score
AM378_22625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AM378_22635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM378_22640	COG2967	ApaG domain
AM378_22645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM378_22650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM378_22655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM378_22660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AM378_22670	COG0564	pseudouridine synthase activity
AM378_22675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM378_22680	COG0417	DNA replication proofreading
AM378_22685	COG0586	Pfam SNARE associated Golgi protein
AM378_22690	COG0440	acetolactate synthase activity
AM378_22695	COG0028	Belongs to the TPP enzyme family
AM378_22710	COG1178	ABC-type Fe3 transport system permease component
AM378_22715	COG4143	(ABC) transporter
AM378_22730	COG2814	Major facilitator Superfamily
AM378_22735	COG0471	metal ion transport
AM378_22740	COG0066	3-isopropylmalate dehydratase activity
AM378_22745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AM378_22750	COG0473	3-isopropylmalate dehydrogenase activity
AM378_22755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM378_22765	COG0583	DNA-binding transcription factor activity
AM378_22770	COG1022	Amp-dependent synthetase and ligase
AM378_22775	COG0028	Belongs to the TPP enzyme family
AM378_22785	COG1609	Transcriptional regulator
AM378_22795	COG2001	Belongs to the MraZ family
AM378_22800	COG0275	rRNA processing
AM378_22805	COG3116	cell division
AM378_22810	COG0768	penicillin binding
AM378_22815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM378_22820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM378_22825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM378_22835	COG0772	Belongs to the SEDS family
AM378_22840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AM378_22845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM378_22855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AM378_22860	COG0849	cell division
AM378_22865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM378_22885	COG0653	protein targeting
AM378_22890	COG0494	nUDIX hydrolase
AM378_22895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AM378_22900	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AM378_22905	COG0237	dephospho-CoA kinase activity
AM378_22910	COG0516	GMP reductase activity
AM378_22915	COG1459	type II secretion system
AM378_22920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM378_22925	COG4969	Belongs to the N-Me-Phe pilin family
AM378_22935	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM378_22940	COG3725	Membrane protein required for beta-lactamase induction
AM378_22945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AM378_22955	COG0316	Belongs to the HesB IscA family
AM378_22965	COG2860	membrane
AM378_22975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM378_22980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AM378_22985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM378_22995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM378_23000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM378_23005	COG3956	TIGRFAM MazG family protein
AM378_23010	COG0504	CTP synthase activity
AM378_23040	COG2986	histidine ammonia-lyase
AM378_23045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AM378_23050	COG2271	Major facilitator Superfamily
AM378_23055	COG0602	queuosine metabolic process
AM378_23060	COG0720	synthase
AM378_23065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AM378_23070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM378_23075	COG0175	sulfate reduction
AM378_23080	COG2234	aminopeptidase activity
AM378_23085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM378_23085	COG1648	precorrin-2 dehydrogenase activity
AM378_23090	COG0175	sulfate reduction
AM378_23095	COG2895	sulfate adenylyltransferase (ATP) activity
AM378_23115	COG0765	amino acid transport
AM378_23125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AM378_23130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AM378_23135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AM378_23140	COG0585	pseudouridine synthase activity
AM378_23145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM378_23150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM378_23155	COG4942	peptidase
AM378_23155	COG1388	LysM domain
AM378_23160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM378_23165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AM378_23185	COG0667	Aldo Keto reductase
AM378_23200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM378_23205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AM378_23210	COG2723	6-phospho-beta-galactosidase activity
AM378_23215	COG2169	Transcriptional regulator
AM378_23215	COG1917	Cupin 2, conserved barrel domain protein
AM378_23240	COG2137	regulation of response to DNA damage stimulus
AM378_23245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM378_23250	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AM378_23275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM378_23280	COG1238	metal cluster binding
AM378_23285	COG2918	glutathione biosynthetic process
AM378_23295	COG4536	flavin adenine dinucleotide binding
AM378_23300	COG4137	Cytochrome C assembly protein
AM378_23305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM378_23310	COG0228	four-way junction DNA binding
AM378_23315	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM378_23325	COG0335	large ribosomal subunit rRNA binding
AM378_23345	COG3137	Salt-induced outer membrane protein
AM378_23350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM378_23355	COG0287	Prephenate dehydrogenase
AM378_23355	COG1605	Chorismate mutase
AM378_23360	COG1605	Chorismate mutase
AM378_23360	COG0077	Prephenate dehydratase
AM378_23370	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM378_23375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM378_23385	COG0564	pseudouridine synthase activity
AM378_23395	COG0542	response to heat
AM378_23425	COG0656	L-ascorbic acid biosynthetic process
AM378_23430	COG0583	DNA-binding transcription factor activity
AM378_23435	COG3021	interspecies interaction between organisms
AM378_23440	COG0741	lytic transglycosylase activity
AM378_23440	COG1388	LysM domain
AM378_23445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM378_23450	COG2226	methyltransferase
AM378_23455	COG0328	RNA-DNA hybrid ribonuclease activity
AM378_23460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM378_23485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM378_23500	COG0436	Aminotransferase
AM378_23505	COG0235	Class ii aldolase
AM378_23510	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AM378_23515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AM378_23520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AM378_23525	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AM378_23535	COG1960	acyl-CoA dehydrogenase activity
AM378_23540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AM378_23545	COG0121	glutamine amidotransferase
AM378_23550	COG3034	peptidoglycan biosynthetic process
AM378_23555	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM378_23560	COG1805	sodium ion transport
AM378_23565	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM378_23570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM378_23575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AM378_23580	COG2871	sodium ion transport
AM378_23585	COG1477	protein flavinylation
AM378_23590	COG2991	Protein conserved in bacteria
AM378_23615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM378_23620	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM378_23625	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AM378_23655	COG0582	viral genome integration into host DNA
AM378_23730	COG3539	Fimbrial protein
AM378_23735	COG3188	usher protein
AM378_23740	COG3121	Chaperone
AM378_23790	COG0583	DNA-binding transcription factor activity
AM378_23795	COG2314	TM2 domain
AM378_23825	COG3038	cytochrome b561
AM378_23830	COG0747	negative chemotaxis
AM378_23835	COG1733	regulation of RNA biosynthetic process
AM378_23840	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM378_23855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM378_23860	COG2207	Transcriptional regulator
AM378_23865	COG1012	belongs to the aldehyde dehydrogenase family
AM378_23875	COG2169	Transcriptional regulator
AM378_23875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM378_23895	COG3961	Belongs to the TPP enzyme family
AM378_23925	COG1349	DNA-binding transcription factor activity
AM378_23930	COG0346	lactoylglutathione lyase activity
AM378_23945	COG1335	isochorismatase
AM378_23960	COG3011	Protein conserved in bacteria
AM378_23970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM378_23975	COG3416	Protein conserved in bacteria
AM378_23985	COG2226	methyltransferase
AM378_23990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AM378_24030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM378_24050	COG1595	DNA-templated transcription, initiation
AM378_24100	COG4126	flavin adenine dinucleotide binding
AM378_24105	COG3123	guanosine phosphorylase activity
AM378_24110	COG2974	May be involved in recombination
AM378_24115	COG1940	carbohydrate kinase activity
AM378_24135	COG0419	ATPase involved in DNA repair
AM378_24140	COG0420	3'-5' exonuclease activity
AM378_24145	COG0745	RESPONSE REGULATOR receiver
AM378_24150	COG5002	protein histidine kinase activity
AM378_24160	COG1114	Component of the transport system for branched-chain amino acids
AM378_24175	COG0668	transmembrane transport
AM378_24180	COG0366	Alpha amylase catalytic
AM378_24190	COG0450	alkyl hydroperoxide reductase
AM378_24195	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AM378_24200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AM378_24205	COG0343	queuine tRNA-ribosyltransferase activity
AM378_24210	COG1862	Preprotein translocase
AM378_24220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM378_24225	COG4238	major outer membrane lipoprotein
AM378_24230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM378_24235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM378_24235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM378_24240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AM378_24245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM378_24250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM378_24255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AM378_24260	COG0667	Aldo Keto reductase
AM378_24265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AM378_24270	COG0142	geranyltranstransferase activity
AM378_24275	COG1722	exodeoxyribonuclease VII activity
AM378_24280	COG0301	tRNA thio-modification
AM378_24280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AM378_24285	COG3210	domain, Protein
AM378_24290	COG2831	hemolysin activation secretion protein
AM378_24295	COG0693	protein deglycase activity
AM378_24300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AM378_24305	COG1666	GTP binding
AM378_24310	COG2814	Major facilitator Superfamily
AM378_24315	COG0109	protoheme IX farnesyltransferase activity
AM378_24320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM378_24325	COG1845	cytochrome c oxidase, subunit III
AM378_24330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM378_24335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM378_24340	COG2223	nitrite transmembrane transporter activity
AM378_24345	COG3056	Lipoprotein
AM378_24350	COG0271	Belongs to the BolA IbaG family
AM378_24355	COG0544	peptidyl-prolyl cis-trans isomerase activity
AM378_24365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AM378_24370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner