locus-tag class description FG170_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FG170_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FG170_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FG170_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FG170_00025 ENOG410667J hydrolase FG170_00035 ENOG4105C7B Threonine dehydratase FG170_00045 ENOG4105D99 atp gtp-binding protein FG170_00050 ENOG4105R2A (LipO)protein FG170_00055 ENOG4108ZNX Heat shock protein FG170_00060 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) FG170_00065 ENOG4105D0C transport protein FG170_00075 ENOG41068KX affects formate dehydrogenase-N FG170_00080 ENOG4105JKW Valine--pyruvate aminotransferase FG170_00085 ENOG4107T9C Alpha amylase catalytic region FG170_00090 ENOG4105C5I Dehydrogenase FG170_00095 ENOG4105JHE Major Facilitator Superfamily FG170_00100 ENOG4105D7K pfkb domain protein FG170_00110 ENOG4108M60 Transcriptional regulator FG170_00115 ENOG4108ZG0 Ompa motb domain protein FG170_00125 ENOG4108R3E Dna-3-methyladenine glycosylase i FG170_00140 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit FG170_00145 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FG170_00150 ENOG4106JH6 (LipO)protein FG170_00155 ENOG4105CTS PTS system mannitol-specific FG170_00160 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FG170_00165 ENOG4105E61 Mannitol repressor protein FG170_00175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FG170_00180 ENOG4108YYI Protein of unknown function (DUF2810) FG170_00190 ENOG4108RPX mosc domain containing protein FG170_00195 ENOG4105C8Q Methyl-accepting chemotaxis FG170_00200 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FG170_00210 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FG170_00215 ENOG4108MG3 formate dehydrogenase FG170_00220 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FG170_00230 ENOG4108U78 Glutathione S-transferase FG170_00235 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) FG170_00240 ENOG4105EM7 Selenocysteine-specific translation elongation factor FG170_00260 ENOG4105MEV Acyl-transferase FG170_00270 ENOG4108RWI nicotinamidase FG170_00275 ENOG4105DZC cytosine deaminase FG170_00290 ENOG4107NQ8 LysR family Transcriptional regulator FG170_00295 ENOG4105DJ2 Major Facilitator Superfamily FG170_00310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FG170_00315 ENOG4105EB3 Histidine kinase FG170_00335 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FG170_00445 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FG170_00450 ENOG4105F27 Major Facilitator FG170_00460 ENOG4105EQ2 LysR family Transcriptional regulator FG170_00465 ENOG4105CHR reductase FG170_00490 ENOG4105K56 Transcriptional regulator FG170_00495 ENOG4108ZHJ Organic hydroperoxide resistance protein FG170_00500 ENOG4105DIJ Phosphoethanolamine transferase FG170_00505 ENOG4108KX4 response regulator FG170_00510 ENOG4105BZU Histidine kinase FG170_00515 ENOG4105CXY transporter FG170_00530 ENOG4105DEF Extracellular solute-binding protein, family 5 FG170_00535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FG170_00540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FG170_00545 ENOG4105C3U ABC transporter FG170_00550 ENOG4108JQ7 (ABC) transporter FG170_00555 ENOG4105D1V cellulose synthase operon protein YhjU FG170_00560 ENOG4105WQA Cellulose biosynthesis protein BcsF FG170_00565 ENOG4105U74 cellulose biosynthesis protein BcsE FG170_00580 ENOG4107QZ7 Cellulose synthase catalytic subunit FG170_00585 ENOG4107EEX Cellulose synthase regulator protein FG170_00590 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FG170_00595 ENOG4105EJG cellulose synthase FG170_00600 ENOG4105BZU Histidine kinase FG170_00605 ENOG4105CK2 sodium dicarboxylate symporter FG170_00610 ENOG4105CS0 peptidase FG170_00615 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FG170_00620 ENOG4105C4R Atp-dependent dna helicase FG170_00625 ENOG4105C9X ppx gppa phosphatase FG170_00630 ENOG4105C1J atp-dependent rna helicase FG170_00635 ENOG4105K63 Thioredoxin FG170_00645 ENOG4105ESV Glycosyl transferase, family 4 FG170_00650 ENOG4105SFE lipopolysaccharide biosynthesis protein FG170_00655 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FG170_00660 ENOG4108IJ1 Dehydrogenase FG170_00665 ENOG4105C1B dTDP-glucose 4-6-dehydratase FG170_00670 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FG170_00675 ENOG4108WJ1 acetyltransferase FG170_00680 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FG170_00685 ENOG4105EGZ biosynthesis protein FG170_00690 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FG170_00695 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) FG170_00700 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FG170_00705 ENOG4105C85 amino acid FG170_00735 ENOG410601J HemY protein FG170_00745 ENOG41076E6 Uroporphyrinogen-III Synthase FG170_00750 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FG170_00760 ENOG4105XQ6 frataxin-like protein FG170_00765 ENOG4105S7Z (LipO)protein FG170_00770 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FG170_00775 ENOG4105CT0 Protein of unknown function, DUF484 FG170_00785 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FG170_00790 ENOG4105C4R Atp-dependent dna helicase FG170_00800 ENOG4107QUT magnesium and cobalt transport protein CorA FG170_00805 ENOG4105FR1 rard protein FG170_00810 ENOG4108VUY thioesterase Superfamily protein FG170_00815 ENOG4105HDD phospholipase FG170_00820 ENOG4105C9U ATP-dependent DNA helicase RecQ FG170_00835 ENOG4108EUD Lysophospholipase FG170_00840 ENOG4105DQF Hydrolase FG170_00845 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FG170_00860 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FG170_00870 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FG170_00875 ENOG4108W1V Lipoprotein FG170_00885 ENOG4105EX9 Membrane FG170_00890 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FG170_00910 ENOG4107FS9 Membrane FG170_00920 ENOG4105MG3 Membrane FG170_00925 ENOG4106H78 methyltransferase FG170_00935 ENOG4105CAK Cell division ATP-binding protein ftsE FG170_00940 ENOG4105CRP Part of the ABC transporter FtsEX involved in FG170_00960 ENOG4105U59 -acetyltransferase FG170_00970 ENOG4105C32 Amino acid ABC transporter (Permease) FG170_00975 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FG170_00980 ENOG4105C0Z ABC transporter FG170_00985 ENOG4108IV0 ABC, transporter FG170_00990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FG170_00995 ENOG4105BZ7 extracellular solute-binding protein family 1 FG170_01000 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FG170_01010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FG170_01015 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FG170_01035 ENOG4105DZ2 Transcriptional regulator FG170_01040 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FG170_01045 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FG170_01050 ENOG4108I5U Uridine phosphorylase FG170_01065 ENOG4108KF1 Membrane FG170_01070 ENOG4105CGY Dna recombination protein FG170_01075 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FG170_01080 ENOG4105JC1 sterol-binding domain protein FG170_01085 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FG170_01105 ENOG4105F8V Hydrolase, tatD family FG170_01110 ENOG4105D52 delta-aminolevulinic acid dehydratase FG170_01115 ENOG4105MDZ Transcriptional activator rfaH FG170_01130 ENOG4107QK7 reductase FG170_01135 ENOG4105CHU acetyl-coa acetyltransferase FG170_01140 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FG170_01150 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FG170_01155 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FG170_01160 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FG170_01165 ENOG4108RR8 protoporphyrinogen oxidase FG170_01195 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FG170_01200 ENOG4105CS9 pantothenic acid kinase FG170_01235 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FG170_01240 ENOG4105PM1 preprotein translocase subunit SecE FG170_01245 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FG170_01260 ENOG4108VZM 50s ribosomal protein L10 FG170_01270 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FG170_01275 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FG170_01290 ENOG4105BZU Histidine kinase FG170_01300 ENOG4105D41 biosynthesis protein thiH FG170_01305 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FG170_01310 ENOG4105WHD thiamine biosynthesis protein ThiS FG170_01315 ENOG4105D06 uba thif-type nad fad binding protein FG170_01320 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FG170_01325 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FG170_01330 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor FG170_01335 ENOG4105E09 nadh pyrophosphatase FG170_01340 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FG170_01345 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FG170_01350 ENOG4105R2J Conserved Protein FG170_01360 ENOG4108T8B Protein of unknown function (DUF1481) FG170_01365 ENOG4105C12 Phosphoribosylglycinamide synthetase FG170_01370 ENOG4105DC1 bifunctional purine biosynthesis protein purh FG170_01400 ENOG4107QN1 sodium solute FG170_01405 ENOG41062QD Membrane FG170_01410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FG170_01415 ENOG4105CK2 sodium dicarboxylate symporter FG170_01425 ENOG4105C0W non-ribosomal peptide synthetase FG170_01430 ENOG4105C0W non-ribosomal peptide synthetase FG170_01435 ENOG4107RBR Receptor FG170_01440 ENOG4105CEY Amp-dependent synthetase and ligase FG170_01445 ENOG4108NS2 receptor FG170_01455 ENOG4105E93 esterase FG170_01480 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FG170_01485 ENOG4105WQI isochorismatase FG170_01490 ENOG4108NS2 receptor FG170_01495 ENOG4108R5S membrane FG170_01525 ENOG4106PG1 outer membrane usher protein FG170_01530 ENOG4108FZ9 Chaperone FG170_01540 ENOG4105UGQ Fimbrial FG170_01575 ENOG4108SIC Transcriptional regulator FG170_01580 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FG170_01590 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FG170_01605 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FG170_01615 ENOG4105C8Q Methyl-accepting chemotaxis FG170_01620 ENOG4108ZVF (LipO)protein FG170_01625 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FG170_01630 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FG170_01635 ENOG4106HKS Entericidin EcnA/B family FG170_01640 ENOG4106BSU Entericidin B FG170_01655 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FG170_01660 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FG170_01675 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FG170_01690 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FG170_01695 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FG170_01715 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FG170_01720 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FG170_01725 ENOG4105K8N protein family UPF0079, ATPase FG170_01730 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FG170_01735 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FG170_01740 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FG170_01745 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FG170_01750 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FG170_01755 ENOG4107QJR hflk protein FG170_01760 ENOG4105EPW hflc protein FG170_01770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FG170_01775 ENOG4105KPV Transcriptional regulator FG170_01785 ENOG4105C2N RNA methyltransferase TrmH family group 3 FG170_01790 ENOG4105CSU acyl-Coa dehydrogenase FG170_01795 ENOG4105Z6B inner membrane protein yjfl FG170_01805 ENOG4105WSB biofilm stress and motility protein A FG170_01810 ENOG4108MXZ Esterase FG170_01825 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FG170_01835 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FG170_01840 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FG170_01850 ENOG4105FHY Opacity-associated protein A FG170_01855 ENOG4108V1T peptidylprolyl cis-trans isomerase FG170_01865 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FG170_01870 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FG170_01875 ENOG4108UUE Transcriptional regulator FG170_01880 ENOG41061GZ Protein of unknown function (DUF1107) FG170_01885 ENOG4105C37 (CBS) domain FG170_01890 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FG170_01895 ENOG4105CFU surface antigen FG170_01900 ENOG4105MA0 exported protein FG170_01905 ENOG4108ZHD aig2 family FG170_01910 ENOG4105F0N pyrophosphate phospho-hydrolase FG170_01915 ENOG4105C8Q Methyl-accepting chemotaxis FG170_01920 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FG170_01925 ENOG4105DFU Cell wall formation (By similarity) FG170_01940 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FG170_01945 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FG170_01950 ENOG4105HVQ Regulatory factor of maltose metabolism FG170_01960 ENOG4105EAH synthase FG170_01965 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FG170_01970 ENOG4105K46 50S ribosomal protein l27 FG170_01975 ENOG4105QYV Membrane FG170_01995 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FG170_02000 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FG170_02005 ENOG4105HBR Rna-binding protein FG170_02010 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FG170_02015 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FG170_02020 ENOG4105EEI dihydropteroate synthase FG170_02025 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FG170_02045 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FG170_02050 ENOG4105CHV Transcription elongation factor NusA FG170_02055 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FG170_02060 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FG170_02065 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FG170_02070 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FG170_02075 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FG170_02090 ENOG4105C1J atp-dependent rna helicase FG170_02095 ENOG41066VF YeeE YedE family protein FG170_02100 ENOG4105KSU Redox protein FG170_02125 ENOG4106RZ4 Peptidase U32 FG170_02130 ENOG4105CFP Peptidase U32 FG170_02135 ENOG4105XPQ lipid carrier protein FG170_02140 ENOG4108YYD acetyltransferase FG170_02145 ENOG41082IR Excinuclease ABC C subunit domain protein FG170_02150 ENOG4105D5Q Arginine ornithine antiporter FG170_02155 ENOG4105CXN decarboxylase FG170_02165 ENOG4108ZPB UPF0306 protein FG170_02170 ENOG4105K4T epimerase FG170_02175 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FG170_02185 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FG170_02190 ENOG4105FD8 phosphonate metabolism protein PhnM FG170_02195 ENOG4105HRV phosphonate c-p lyase system protein phnl FG170_02200 ENOG4105ENV phosphonate C-P lyase system protein PhnK FG170_02205 ENOG4105FT8 Phosphonate metabolism FG170_02210 ENOG4105EKV Phosphonate metabolism protein FG170_02215 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FG170_02220 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FG170_02225 ENOG4107RJJ Transcriptional regulator FG170_02230 ENOG4107S21 permease FG170_02235 ENOG4105K5X acetyltransferase FG170_02245 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FG170_02250 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FG170_02255 ENOG410642W LysR family Transcriptional regulator FG170_02260 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FG170_02265 ENOG4105CG3 alpha amylase, catalytic region FG170_02270 ENOG4105C5Y PTS System FG170_02275 ENOG4105D4X repressor FG170_02280 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FG170_02285 ENOG4105E2D ec 3.2.1.52 FG170_02295 ENOG4105KME endoribonuclease L-psp FG170_02305 ENOG4105CXT aspartate transcarbamylase FG170_02315 ENOG4105DBV ornithine carbamoyltransferase FG170_02320 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FG170_02325 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FG170_02330 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FG170_02335 ENOG4108MJ3 acetyltransferase FG170_02345 ENOG4105MYG DNA polymerase iii, chi subunit FG170_02350 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FG170_02355 ENOG4108M8S permease YjgP YjgQ family protein FG170_02360 ENOG4108K5H permease YjgP YjgQ family protein FG170_02375 ENOG4107YC3 synthase FG170_02385 ENOG4105EDR glucose galactose transporter FG170_02395 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FG170_02420 ENOG4105DZR Type I site-specific deoxyribonuclease FG170_02445 ENOG4106H3A restriction FG170_02475 ENOG4105CKI cobalamin synthesis protein FG170_02480 ENOG4105VCD cytoplasmic protein FG170_02485 ENOG4105D22 carbon starvation protein FG170_02490 ENOG4105FBW Monooxygenase FG170_02525 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FG170_02535 ENOG4105CFQ glutamine synthetase FG170_02555 ENOG4106NZI LysR family Transcriptional regulator FG170_02560 ENOG4105D6N CoA-transferase, subunit a FG170_02570 ENOG4105CHU acetyl-coa acetyltransferase FG170_02575 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FG170_02585 ENOG4105DTD Dehydrogenase FG170_02595 ENOG4105R1U AraC Family Transcriptional Regulator FG170_02605 ENOG4105UEI Transcriptional Regulator AraC Family FG170_02610 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FG170_02660 ENOG4105C26 Dehydrogenase FG170_02665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FG170_02670 ENOG4105EVZ LysR family transcriptional regulator FG170_02675 ENOG4105C0A alcohol dehydrogenase FG170_02680 ENOG4108UDW Transcriptional regulator, luxr family FG170_02685 ENOG4105CJP fad dependent oxidoreductase FG170_02695 ENOG4105E5G Alpha beta hydrolase fold FG170_02700 ENOG4105DGU Histone deacetylase FG170_02710 ENOG4108UAJ Transcriptional regulator FG170_02715 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FG170_02725 ENOG4105C85 amino acid FG170_02745 ENOG4105CHR reductase FG170_02750 ENOG4108V8F Transcriptional regulator, MarR family FG170_02765 ENOG4105C26 Dehydrogenase FG170_02800 ENOG4105EFA 4-hydroxyphenylacetate FG170_02805 ENOG4107UWN reductase FG170_02810 ENOG4107R6D beta-lactam binding protein AmpH FG170_02820 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FG170_02825 ENOG4105ERH Fumarylacetoacetate hydrolase FG170_02830 ENOG4105DIA mandelate racemase muconate lactonizing FG170_02840 ENOG4105CHR reductase FG170_02845 ENOG4105QJH Domain of unknown function (DUF718) FG170_02855 ENOG4105F27 Major Facilitator FG170_02870 ENOG4105BZU Histidine kinase FG170_02875 ENOG4105YBH Protein of unknown function (DUF1435) FG170_02900 ENOG4105CPC Aldo Keto reductase FG170_02905 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FG170_02910 ENOG4108WPU DNA polymerase III subunit psi FG170_02915 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FG170_02930 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FG170_02935 ENOG4105K3G Periplasmic Protein FG170_02945 ENOG4105VDW Csbd family FG170_02950 ENOG4108NRW Phospholipase, patatin family FG170_02955 ENOG4105EYA deoxyribonuclease FG170_02960 ENOG4105D9N nucleoside FG170_02965 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FG170_02970 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FG170_02975 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FG170_02980 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FG170_02985 ENOG41062Z9 Membrane FG170_02990 ENOG4105EAC phosphoserine phosphatase FG170_02995 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FG170_03000 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FG170_03010 ENOG4105CIS alcohol dehydrogenase FG170_03020 ENOG4105C5H ABC transporter FG170_03025 ENOG41090EK ompa motb domain protein FG170_03030 ENOG4108KHX Diguanylate cyclase FG170_03035 ENOG4108WS1 FG170_03040 ENOG4107SC1 transglycosylase FG170_03045 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FG170_03050 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FG170_03055 ENOG4105CVJ phosphoglycerate mutase FG170_03060 ENOG4105UEI Transcriptional Regulator AraC Family FG170_03065 ENOG4108RH0 Crea protein FG170_03070 ENOG41065U4 response regulator FG170_03100 ENOG4105D1Q UPF0246 protein FG170_03110 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FG170_03115 ENOG4108RIR Molybdenum cofactor biosynthesis protein FG170_03125 ENOG4106HK8 GPR1 FUN34 yaaH family protein FG170_03130 ENOG4105CFG Acts as a chaperone (By similarity) FG170_03135 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FG170_03140 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FG170_03145 ENOG41063Z6 transcriptional regulator, lysR family FG170_03150 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FG170_03155 ENOG410647N response to DNA damage stimulus FG170_03160 ENOG4105DTN riboflavin biosynthesis protein ribF FG170_03165 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FG170_03170 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FG170_03175 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FG170_03180 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FG170_03185 ENOG4105HEI LysR family (Transcriptional regulator FG170_03205 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FG170_03210 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FG170_03215 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FG170_03230 ENOG4108NIW Leucine export protein LeuE FG170_03235 ENOG4105DWK Membrane FG170_03245 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FG170_03255 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FG170_03260 ENOG4105NWN ApaG protein FG170_03265 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FG170_03270 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FG170_03280 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FG170_03290 ENOG4105D3G Pseudouridine synthase FG170_03295 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FG170_03300 ENOG4105CQ2 DNA polymerase FG170_03310 ENOG4105M71 acetolactate synthase 1 regulatory subunit FG170_03315 ENOG4105C7K acetolactate synthase FG170_03330 ENOG4106SMU thiamine transporter membrane protein FG170_03335 ENOG4105DP9 ABC transporter FG170_03355 ENOG4107QPK )-transporter FG170_03360 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FG170_03365 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FG170_03370 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FG170_03375 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FG170_03385 ENOG41064T2 transcriptional regulator, lysR family FG170_03390 ENOG4108IQE Amp-dependent synthetase and ligase FG170_03395 ENOG4105C7K acetolactate synthase FG170_03400 ENOG4108ZP8 Acetolactate synthase small subunit FG170_03405 ENOG4107B7Y DNA-binding transcriptional regulator FruR FG170_03410 ENOG4108RNS Exports L-alanine (By similarity) FG170_03415 ENOG4108V6E Cell division protein mraZ FG170_03420 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FG170_03425 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FG170_03430 ENOG4105CJN penicillin-binding protein FG170_03435 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FG170_03440 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FG170_03445 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FG170_03455 ENOG4105CNI cell division protein FtsW FG170_03460 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FG170_03465 ENOG4105DFU Cell wall formation (By similarity) FG170_03475 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FG170_03480 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FG170_03485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FG170_03500 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FG170_03505 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FG170_03510 ENOG4105M6F mutator MutT protein FG170_03515 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FG170_03520 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FG170_03525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FG170_03530 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FG170_03535 ENOG4105D7Q type ii secretion system FG170_03540 ENOG4107QHF type ii secretion system protein e FG170_03545 ENOG4108ZUW Major pilin subunit FG170_03550 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FG170_03555 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FG170_03560 ENOG4106A72 regulatory protein AmpE FG170_03565 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FG170_03575 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FG170_03585 ENOG4105EN6 Membrane FG170_03595 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FG170_03600 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FG170_03605 ENOG4105C0H protease FG170_03610 ENOG4105BZU Histidine kinase FG170_03615 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FG170_03620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FG170_03625 ENOG4105DXN mazG family FG170_03630 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FG170_03655 ENOG4105C85 amino acid FG170_03665 ENOG4105CGP Urocanate hydratase FG170_03670 ENOG4105D2S major facilitator superfamily FG170_03675 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FG170_03685 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FG170_03690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FG170_03695 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FG170_03700 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FG170_03705 ENOG4108MXK alkaline phosphatase isozyme conversion FG170_03710 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FG170_03720 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FG170_03725 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) FG170_03730 ENOG4105N0Z inner membrane protein ygbE FG170_03740 ENOG4105DRP amino acid AbC transporter FG170_03745 ENOG4106PMH Extracellular solute-binding protein family 3 FG170_03750 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FG170_03755 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FG170_03760 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FG170_03770 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FG170_03775 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FG170_03780 ENOG4108K5P (LipO)protein FG170_03785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FG170_03790 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FG170_03825 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FG170_03915 ENOG4105CPC Aldo Keto reductase FG170_03920 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FG170_03925 ENOG4105EQ2 LysR family Transcriptional regulator FG170_03930 ENOG4105VZJ PTS System FG170_03935 ENOG4105CK1 PTS System FG170_03940 ENOG4105CS2 ec 3.2.1.21 FG170_03945 ENOG4105EZV Transcriptional regulator FG170_03970 ENOG4105Y3E Modulates RecA activity (By similarity) FG170_03975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FG170_03980 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FG170_04005 ENOG4107VXZ Hydrolase FG170_04010 ENOG4105W39 Membrane FG170_04015 ENOG4105D9M gamma-glutamylcysteine synthetase FG170_04030 ENOG4106KVJ cytochrome C assembly protein FG170_04040 ENOG4105K5M 30s ribosomal protein S16 FG170_04045 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FG170_04055 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FG170_04060 ENOG4105ZTC transcriptional activator, Ogr delta FG170_04075 ENOG4108NE3 Salt-induced outer membrane protein FG170_04080 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FG170_04085 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FG170_04090 ENOG4105CQC Prephenate dehydratase FG170_04100 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FG170_04105 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FG170_04115 ENOG4105C34 Pseudouridine synthase FG170_04120 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FG170_04125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FG170_04155 ENOG4105CV8 reductase FG170_04160 ENOG4105HEI LysR family (Transcriptional regulator FG170_04165 ENOG4105F27 Major Facilitator FG170_04175 ENOG4105E9H Lytic Murein transglycosylase FG170_04180 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FG170_04185 ENOG4105D1A Methyltransferase FG170_04190 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FG170_04195 ENOG4107RZZ dna polymerase iii epsilon subunit FG170_04220 ENOG4105CHM Aminotransferase FG170_04225 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FG170_04235 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FG170_04240 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FG170_04255 ENOG4107QPN acyl-Coa dehydrogenase FG170_04260 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FG170_04265 ENOG4105E7A Glutamine amidotransferase FG170_04270 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FG170_04275 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FG170_04280 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FG170_04285 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FG170_04290 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FG170_04295 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FG170_04300 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FG170_04305 ENOG4105CJ2 (LipO)protein FG170_04315 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FG170_04325 ENOG4105CIN aminoacyl-histidine dipeptidase FG170_04330 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FG170_04335 ENOG4105V1F Fermentation respiration switch protein FG170_04340 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FG170_04360 ENOG4105HVQ Regulatory factor of maltose metabolism FG170_04385 ENOG4105YB8 TM2 domain containing protein FG170_04415 ENOG4105CPW cytochrome b561 FG170_04420 ENOG4105DEF Extracellular solute-binding protein, family 5 FG170_04425 ENOG4108MEJ flavin reductase domain protein FG170_04430 ENOG4105KVH Transcriptional regulator FG170_04435 ENOG4108X0B nad(p)h dehydrogenase (quinone) FG170_04450 ENOG4108Z33 Thiol disulfide Interchange Protein FG170_04460 ENOG4108WFR AraC Family Transcriptional Regulator FG170_04465 ENOG4105C26 Dehydrogenase FG170_04475 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FG170_04495 ENOG4107QS8 (LipO)protein FG170_04500 ENOG4107RA9 decarboxylase FG170_04510 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FG170_04515 ENOG4105RI1 glycoprotein receptor FG170_04535 ENOG4105E98 transcriptional regulator DeoR family FG170_04540 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FG170_04545 ENOG4105JQN Transcriptional regulator FG170_04550 ENOG4105EUB pirin domain protein FG170_04555 ENOG4105CHJ isochorismatase hydrolase FG170_04565 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FG170_04575 ENOG41068WN FG170_04580 ENOG4105G4C Periplasmic ligand-binding sensor protein FG170_04590 ENOG4105F2W methyltransferase FG170_04595 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FG170_04640 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FG170_04655 ENOG4105SS3 FG170_04660 ENOG4108SF5 RNA Polymerase FG170_04695 ENOG4107258 Transcriptional regulator FG170_04710 ENOG4105HBA AroM protein FG170_04715 ENOG4105NBK UPF0345 protein FG170_04720 ENOG4105DH7 May be involved in recombination (By similarity) FG170_04725 ENOG4105DKQ ROK family FG170_04745 ENOG4105EYH Exonuclease FG170_04750 ENOG4107RH8 nuclease SbcCD subunit D FG170_04755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FG170_04760 ENOG4105BZU Histidine kinase FG170_04770 ENOG4105CWM branched-chain amino acid transport system II carrier protein FG170_04775 ENOG4105C85 amino acid FG170_04785 ENOG4105CUY Mechanosensitive ion channel FG170_04790 ENOG4107R28 alpha amylase, catalytic region FG170_04800 ENOG4105D3R alkyl hydroperoxide reductase FG170_04805 ENOG4108ZYK Acyl carrier protein phosphodiesterase FG170_04810 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FG170_04815 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FG170_04820 ENOG4105VIE preprotein translocase, subunit YajC FG170_04830 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FG170_04835 ENOG4108KIC (LipO)protein FG170_04840 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FG170_04845 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FG170_04850 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FG170_04855 ENOG4107YIM Involved in the transcription termination process (By similarity) FG170_04860 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FG170_04865 ENOG4108ZAI phosphatidylglycerophosphatase a FG170_04870 ENOG4105CPC Aldo Keto reductase FG170_04875 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FG170_04880 ENOG4105CTB Polyprenyl synthetase FG170_04885 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FG170_04890 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FG170_04895 ENOG4107S0N DJ-1 family FG170_04900 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FG170_04905 ENOG4108VPT UPF0234 protein FG170_04910 ENOG4107RDB Major Facilitator FG170_04915 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FG170_04920 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FG170_04925 ENOG4105CCU oxidase (Subunit III) FG170_04930 ENOG4105BZ9 Cytochrome C oxidase, subunit I FG170_04935 ENOG4105E2S oxidase) subunit II FG170_04940 ENOG4105EYM Major Facilitator superfamily FG170_04945 ENOG4105IEY (LipO)protein FG170_04950 ENOG4105M85 Bola protein FG170_04955 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FG170_04965 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FG170_04970 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FG170_04980 ENOG4105EIN peptidylprolyl cis-trans isomerase FG170_04985 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FG170_04990 ENOG4108TGP Thioesterase superfamily protein FG170_04995 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FG170_05000 ENOG4108NFA extracellular solute-binding protein FG170_05005 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) FG170_05015 ENOG4108XM1 transcriptional regulator AsnC family FG170_05020 ENOG4105BZ1 (ABC) transporter FG170_05025 ENOG4105BZ1 (ABC) transporter FG170_05030 ENOG4108YZA Nitrogen regulatory protein pii FG170_05035 ENOG4105BZU Histidine kinase FG170_05040 ENOG4105C29 acyl-CoA thioesterase FG170_05045 ENOG4108MNP Glycoprotein polysaccharide metabolism FG170_05050 ENOG41080UX Methyltransferase FG170_05060 ENOG4105KF5 hemolysin expression-modulating protein FG170_05065 ENOG4108UKR Biofilm formation regulator YbaJ FG170_05075 ENOG4105DIK (ABC) transporter FG170_05080 ENOG4105CC5 ABC transporter FG170_05085 ENOG4105DSE periplasmic solute binding protein FG170_05090 ENOG4105YK5 50S ribosomal protein L36 FG170_05095 ENOG4105NRA 50s ribosomal protein l31 type b FG170_05100 ENOG4105BZS acriflavin resistance protein FG170_05105 ENOG4105C1P efflux transporter, rnd family, mfp subunit FG170_05110 ENOG4108IG5 Transcriptional regulator FG170_05115 ENOG41090EX DsrE family FG170_05120 ENOG4105EGS Mechanosensitive ion channel FG170_05125 ENOG4106428 Protein of unknown function (DUF2496) FG170_05135 ENOG4105WD1 Membrane FG170_05140 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FG170_05150 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FG170_05155 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FG170_05160 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FG170_05165 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FG170_05170 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FG170_05175 ENOG4107QQ0 gntp family FG170_05185 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FG170_05190 ENOG4107RE1 Inosine-guanosine kinase FG170_05195 ENOG4105CKD glutathione-regulated potassium-efflux system protein FG170_05200 ENOG4105EU0 Major facilitator Superfamily FG170_05205 ENOG4105CGH 5'-nucleotidase FG170_05215 ENOG4105C2C drug resistance transporter, Bcr CflA FG170_05220 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FG170_05225 ENOG4108Z66 YbaK ebsC protein FG170_05230 ENOG4105MBR gumn family FG170_05235 ENOG4105C59 p-type ATPase FG170_05240 ENOG4108Z6Z Transcriptional regulator FG170_05245 ENOG4105G5H Membrane FG170_05250 ENOG4107QX8 SPFH domain, Band 7 family protein FG170_05255 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FG170_05260 ENOG4107QR8 Thioredoxin FG170_05265 ENOG4105E1F short-chain dehydrogenase reductase FG170_05270 ENOG4108UJV acyl-CoA thioesterase i FG170_05285 ENOG4107QNK )-transporter FG170_05290 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FG170_05295 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FG170_05300 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FG170_05305 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FG170_05310 ENOG4105C8N cysteinyl-tRNA synthetase FG170_05315 ENOG4105WQ3 Rna-binding protein FG170_05320 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FG170_05355 ENOG4105BZU Histidine kinase FG170_05360 ENOG4105VEQ Cold shock protein FG170_05370 ENOG4105CDA abc transporter atp-binding protein FG170_05375 ENOG4105DRP amino acid AbC transporter FG170_05395 ENOG4105CH2 amidohydrolase FG170_05400 ENOG4105VEQ Cold shock protein FG170_05405 ENOG4105C2C drug resistance transporter, Bcr CflA FG170_05410 ENOG41067SE Tetr family transcriptional regulator FG170_05415 ENOG4107Z6W Protein CrcB homolog FG170_05425 ENOG4105BZU Histidine kinase FG170_05430 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FG170_05435 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FG170_05440 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FG170_05445 ENOG4108Z43 UPF0250 protein FG170_05450 ENOG4105DZ1 carboxypeptidase FG170_05455 ENOG4105K6T rare lipoprotein A FG170_05460 ENOG4105CNI cell division protein FtsW FG170_05465 ENOG4105CJN penicillin-binding protein FG170_05470 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FG170_05475 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FG170_05480 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FG170_05485 ENOG4105DJF DNA polymerase III, delta' subunit FG170_05490 ENOG4108U2H Rare lipoprotein B FG170_05495 ENOG4105C8T Leucyl-tRNA synthetase FG170_05500 ENOG4107PAI alpha helical protein FG170_05515 ENOG4105CDA abc transporter atp-binding protein FG170_05520 ENOG4105DRP amino acid AbC transporter FG170_05525 ENOG4105EAD ABC transporter FG170_05530 ENOG4107RP9 extracellular solute-binding protein, family 3 FG170_05535 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FG170_05540 ENOG4108JU5 Magnesium and cobalt efflux protein FG170_05545 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FG170_05550 ENOG4105C9A Phoh family FG170_05555 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FG170_05560 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FG170_05565 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FG170_05600 ENOG4105CAQ asparagine synthetase FG170_05605 ENOG4105E03 chitinase FG170_05610 ENOG4105D4U had-superfamily hydrolase, subfamily iia FG170_05615 ENOG4105E2R ROK family FG170_05620 ENOG4105CE4 GlcNAc 6-P deacetylase FG170_05625 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FG170_05630 ENOG4105CI1 PTS System FG170_05635 ENOG4105CX6 glutaminyL-tRNA synthetase FG170_05640 ENOG4105J5J Outer membrane porin FG170_05645 ENOG4105GX6 (LipO)protein FG170_05655 ENOG41090R7 Ferric uptake FG170_05660 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FG170_05665 ENOG4105NNH LexA regulated protein FG170_05670 ENOG4105EV9 Alpha Beta Hydrolase FG170_05680 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FG170_05685 ENOG4105NTW Transcriptional regulator FG170_05695 ENOG4105EEX Two component transcriptional regulator (Winged helix family FG170_05705 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FG170_05710 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FG170_05715 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FG170_05725 ENOG4105XIQ Protein of unknown function (DUF2517) FG170_05730 ENOG4107SEY Conserved Protein FG170_05735 ENOG4105CVP deoxyribo-dipyrimidine photolyase FG170_05740 ENOG4107RF4 Phosphodiesterase FG170_05745 ENOG4107QNR UPF0135 protein FG170_05750 ENOG4105P4J Allophanate hydrolase, subunit 1 FG170_05760 ENOG4105E7W lamb ycsf family protein FG170_05785 ENOG4105BZN citrate synthase FG170_05790 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FG170_05795 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FG170_05800 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FG170_05805 ENOG4105E33 succinate dehydrogenase FG170_05810 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FG170_05815 ENOG4105C7S Dehydrogenase FG170_05820 ENOG4105CMV Succinyl-CoA synthetase subunit beta FG170_05825 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FG170_05830 ENOG4105CGH 5'-nucleotidase FG170_05835 ENOG4105C4M (Ubiquinol oxidase) subunit I FG170_05840 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FG170_05850 ENOG4105KJB cyd operon protein YbgE FG170_05855 ENOG4107YD3 Thioesterase FG170_05860 ENOG4105E02 MotA TolQ exbB proton channel FG170_05865 ENOG4105M8F Biopolymer transport protein exbD tolR FG170_05875 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FG170_05880 ENOG4105KCK Peptidoglycan-associated lipoprotein FG170_05885 ENOG4105UFD tol-pal system protein YbgF FG170_05935 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FG170_05940 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FG170_05945 ENOG4105PGM cation diffusion facilitator family transporter FG170_05950 ENOG4105BZU Histidine kinase FG170_05955 ENOG4108WQH regulatoR FG170_05960 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FG170_05975 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FG170_05985 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FG170_05995 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FG170_06010 ENOG4105DKW ABC transporter FG170_06015 ENOG4105F4R Transcriptional regulator mode FG170_06030 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FG170_06040 ENOG4105E0A ABC, transporter FG170_06045 ENOG410680R Protein of unknown function (DUF2592) FG170_06050 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FG170_06055 ENOG4105E0C molybdate abc transporter FG170_06065 ENOG4108K4B hydrolase FG170_06070 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FG170_06075 ENOG4108V1U phospholipid-binding protein FG170_06080 ENOG4105PGM cation diffusion facilitator family transporter FG170_06125 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FG170_06130 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FG170_06135 ENOG4105CHW UPF0052 protein FG170_06145 ENOG4108RIR Molybdenum cofactor biosynthesis protein FG170_06150 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FG170_06155 ENOG4105M00 molybdopterin converting factor, subunit 1 FG170_06160 ENOG4108ZAF Molybdopterin FG170_06165 ENOG4105HFZ Membrane FG170_06170 ENOG4107QWP ABC-2 type transporter FG170_06175 ENOG4107QWP ABC-2 type transporter FG170_06180 ENOG4105CJ1 ABC, transporter FG170_06190 ENOG4107MVR Transcriptional regulator FG170_06195 ENOG4105C1J atp-dependent rna helicase FG170_06200 ENOG4108JQ1 Dehydrogenase FG170_06205 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FG170_06215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FG170_06220 ENOG4107RCV ABC transporter, permease FG170_06225 ENOG4105C4Y ABC transporter FG170_06230 ENOG4105CXY transporter FG170_06240 ENOG4108KX4 response regulator FG170_06245 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FG170_06255 ENOG4108N2Y auxin Efflux FG170_06270 ENOG4105CHR reductase FG170_06280 ENOG4105W8I Transcriptional regulator FG170_06290 ENOG4105C85 amino acid FG170_06310 ENOG4105KHU inner membrane protein YohD FG170_06320 ENOG4105ECQ AraC Family Transcriptional Regulator FG170_06325 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FG170_06330 ENOG41061WM D-Alanyl-D-Alanine FG170_06350 ENOG4108MA7 Inherit from COG: YD repeat protein FG170_06380 ENOG4105CKW Inner membrane protein yedI FG170_06395 ENOG4105D01 (LipO)protein FG170_06405 ENOG4108U7W acetyltransferase FG170_06415 ENOG41069YE inner membrane protein yohC FG170_06430 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FG170_06440 ENOG4105EHG Permease protein FG170_06445 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FG170_06450 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FG170_06455 ENOG4105CXG d-lactate dehydrogenase FG170_06460 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FG170_06470 ENOG4105CPF Cell wall formation (By similarity) FG170_06475 ENOG4105E89 ABC transporter FG170_06480 ENOG4105CHM Aminotransferase FG170_06490 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FG170_06510 ENOG4105S10 periplasmic binding protein FG170_06515 ENOG4105EHG Permease protein FG170_06520 ENOG4108W0P ABC transporter FG170_06525 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein FG170_06540 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) FG170_06565 ENOG4107QJE Chromosome Partitioning Protein FG170_06570 ENOG4105N1F Hnh endonuclease FG170_06575 ENOG4105CC0 LysR family Transcriptional regulator FG170_06580 ENOG4107RTG Major Facilitator superfamily FG170_06590 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FG170_06595 ENOG4108594 Permease of the drug metabolite transporter FG170_06620 ENOG4105E5K Alpha-amylase FG170_06625 ENOG4108MJ3 acetyltransferase FG170_06635 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FG170_06640 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FG170_06645 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FG170_06650 ENOG4108IND Tetr family transcriptional regulator FG170_06655 ENOG4105D01 (LipO)protein FG170_06660 ENOG4108UMI ABC transporter, permease FG170_06665 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FG170_06670 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FG170_06690 ENOG4106KE4 Dehydrogenase FG170_06705 ENOG4105EHI Phosphonate ABC transporter, periplasmic FG170_06720 ENOG4108W15 Protein of unknown function (DUF1456) FG170_06740 ENOG4105DRR Transcriptional regulator, GntR family FG170_06750 ENOG4105C32 Amino acid ABC transporter (Permease) FG170_06755 ENOG4105CNN ABC, transporter FG170_06760 ENOG4105C0Z ABC transporter FG170_06835 ENOG4107NQ8 LysR family Transcriptional regulator FG170_06840 ENOG4105KHC sulfurtransferase FG170_06860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FG170_06870 ENOG4108TGY Glutathione S-transferase FG170_06880 ENOG4105EFZ amidohydrolase FG170_06890 ENOG4105CHJ isochorismatase hydrolase FG170_06895 ENOG4105EQ1 Transcriptional regulator FG170_06915 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FG170_06920 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FG170_06925 ENOG4108IJ8 ABC transporter FG170_06930 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FG170_06945 ENOG4105CR8 Transcriptional regulator FG170_06950 ENOG4105FDR Membrane FG170_06995 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FG170_07000 ENOG4105K5X acetyltransferase FG170_07010 ENOG4108N27 Glutathione S-transferase FG170_07020 ENOG4105MDS 4-oxalocrotonate tautomerase FG170_07040 ENOG4108JU7 Transcriptional regulator FG170_07045 ENOG4105CR4 methylisocitrate lyase FG170_07050 ENOG4105BZN citrate synthase FG170_07055 ENOG4105DXD 2-methylcitrate dehydratase FG170_07060 ENOG410829K Lysine exporter protein (Lyse ygga) FG170_07080 ENOG4108MTB glycosyl transferase family FG170_07090 ENOG4107B2H carbonic anhydrase FG170_07095 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FG170_07100 ENOG4105EW6 flavin reductase domain protein, FMN-binding FG170_07110 ENOG4107SDU Methyl-accepting chemotaxis FG170_07130 ENOG4105D8X mechanosensitive ion channel FG170_07135 ENOG4105CDA abc transporter atp-binding protein FG170_07140 ENOG4105E5Q amino acid AbC transporter FG170_07145 ENOG4107R0W ABC transporter FG170_07150 ENOG4105KSC Transcriptional regulator, TraR DksA family FG170_07165 ENOG4108R66 Conserved Protein FG170_07175 ENOG4108T1M outer membrane protein x FG170_07180 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FG170_07195 ENOG4105C6Z Gluconate FG170_07200 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FG170_07205 ENOG4105FB2 class II Aldolase FG170_07210 ENOG4105G63 Type III effector Hrp-dependent FG170_07215 ENOG4105ZXK Dehydrogenase FG170_07220 ENOG4105MVE transcriptional regulator FG170_07230 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FG170_07235 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) FG170_07255 ENOG4105BZU Histidine kinase FG170_07260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FG170_07265 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) FG170_07270 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FG170_07285 ENOG4105C94 Transporter FG170_07290 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FG170_07295 ENOG4105C26 Dehydrogenase FG170_07300 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FG170_07305 ENOG4105CBC glutamate synthase FG170_07315 ENOG4105CMB EAL domain-containing protein FG170_07320 ENOG4105X0I Fimbrial FG170_07340 ENOG4105UEI Transcriptional Regulator AraC Family FG170_07345 ENOG4105DWT malate dehydrogenase (quinone) FG170_07355 ENOG4105CYM Glutathione S-transferase FG170_07360 ENOG4108ZHR arsR family transcriptional regulator FG170_07375 ENOG4105EQ2 LysR family Transcriptional regulator FG170_07390 ENOG4105YCT UPF0386 protein FG170_07395 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FG170_07400 ENOG4107B2H carbonic anhydrase FG170_07405 ENOG4105DND Transcriptional regulator FG170_07430 ENOG4105C5H ABC transporter FG170_07435 ENOG4105D06 uba thif-type nad fad binding protein FG170_07440 ENOG4105CVM Molybdenum cofactor synthesis domain protein FG170_07455 ENOG4108JQ6 ABC transporter FG170_07460 ENOG4105DEF Extracellular solute-binding protein, family 5 FG170_07470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FG170_07495 ENOG4105EGI Transcriptional regulator FG170_07500 ENOG4105CBP Major Facilitator FG170_07505 ENOG4105EUJ GTP cyclohydrolase i FG170_07510 ENOG4105DHF Membrane FG170_07515 ENOG41060NJ transcriptional regulator FG170_07540 ENOG4107GZ4 SanA protein FG170_07555 ENOG4105PSV Polysaccharide Biosynthesis Protein FG170_07560 ENOG4107R1I NAD-dependent malic enzyme FG170_07565 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FG170_07570 ENOG41067MG lrgb family FG170_07575 ENOG4105VAW lrga family FG170_07580 ENOG4105E5W Transporter FG170_07590 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FG170_07595 ENOG4105D1F ATP-binding protein FG170_07600 ENOG4105MH5 phosphoesterase PA-phosphatase related protein FG170_07605 ENOG4105DBI uridine monophosphokinase FG170_07610 ENOG4105DHP deoxycytidine triphosphate deaminase FG170_07615 ENOG4108GAE asmA family FG170_07620 ENOG4105CEE C4-dicarboxylate transporter FG170_07625 ENOG4105EE5 Membrane protein terC FG170_07630 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FG170_07635 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FG170_07640 ENOG4105DAY polysaccharide export protein FG170_07645 ENOG4107ZF2 Phosphatase FG170_07685 ENOG4108KMV Glycosyl transferase (Group 1 FG170_07705 ENOG4108JJ6 Type I secretion system ATPase FG170_07710 ENOG4107QZV Type I secretion membrane fusion protein FG170_07720 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FG170_07725 ENOG4107QKV phosphomannomutase FG170_07740 ENOG4105CMR udp-glucose 4-epimerase FG170_07745 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FG170_07760 ENOG4105EY8 ABC transporter FG170_07795 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FG170_07800 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FG170_07805 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FG170_07810 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FG170_07815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FG170_07820 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FG170_07825 ENOG4105CIH Imidazole acetol-phosphate transaminase FG170_07830 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FG170_07835 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FG170_07845 ENOG4108535 NAD dependent epimerase/dehydratase family FG170_07850 ENOG4105CC0 LysR family Transcriptional regulator FG170_07855 ENOG4105F27 Major Facilitator FG170_07860 ENOG4105EVZ LysR family transcriptional regulator FG170_07870 ENOG4107QN1 sodium solute FG170_07875 ENOG4105ETS cytosine purines uracil thiamine allantoin FG170_07880 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FG170_07885 ENOG4105D7N magnesium and cobalt transport protein CorA FG170_07895 ENOG4105D8V Glucose sorbosone dehydrogenase FG170_07920 ENOG4105C28 cystathionine FG170_07930 ENOG4105DZ1 carboxypeptidase FG170_07955 ENOG4108RQP Major type 1 subunit fimbrin FG170_07960 ENOG4106PG1 outer membrane usher protein FG170_07965 ENOG4108FZ9 Chaperone FG170_07985 ENOG4108V1T peptidylprolyl cis-trans isomerase FG170_07990 ENOG41068CG regulatoR FG170_07995 ENOG4105EJQ L-serine dehydratase FG170_08000 ENOG4105C44 Serine transporter FG170_08010 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FG170_08020 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FG170_08030 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) FG170_08060 ENOG4108KPJ rna polymerase sigma factor FG170_08065 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FG170_08070 ENOG4105D0C transport protein FG170_08080 ENOG41090BQ Glutaredoxin FG170_08085 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FG170_08090 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FG170_08095 ENOG4108RMJ sensory transduction regulator FG170_08100 ENOG4107RUE extracellular solute-binding protein family 1 FG170_08105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FG170_08110 ENOG4105F38 ABC transporter, permease FG170_08115 ENOG4105D38 putrescine abc transporter FG170_08120 ENOG4105RBQ inner membrane protein ybjO FG170_08125 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) FG170_08130 ENOG4106TNF Periplasmic binding protein FG170_08135 ENOG4105DMR ABC, transporter FG170_08140 ENOG4105GBT ABC transporter FG170_08145 ENOG4106PMH Extracellular solute-binding protein family 3 FG170_08150 ENOG4105E5Z arginine transporter ATP-binding subunit FG170_08155 ENOG41064MM (LipO)protein FG170_08160 ENOG4105K8R UPF0145 protein FG170_08170 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FG170_08175 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FG170_08180 ENOG4105CGD Nad-dependent epimerase dehydratase FG170_08190 ENOG4105C5W Aldolase FG170_08195 ENOG4105C7K acetolactate synthase FG170_08200 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FG170_08210 ENOG4105DWU Membrane FG170_08215 ENOG4105CPB ATP-dependent endonuclease of the OLD family FG170_08220 ENOG4108MJ5 VirK protein FG170_08225 ENOG4105DJY efflux transporter, rnd family, mfp subunit FG170_08235 ENOG4105VEQ Cold shock protein FG170_08240 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FG170_08245 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FG170_08250 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FG170_08255 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FG170_08260 ENOG4108JJ8 (ABC) transporter FG170_08265 ENOG4108JJ9 ABC, transporter FG170_08270 ENOG4108K3A Glutathione S-transferase FG170_08275 ENOG4108M0I Transcriptional regulator FG170_08280 ENOG4105C3M thioredoxin reductase FG170_08285 ENOG4105EW9 transcriptional regulator AsnC family FG170_08295 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FG170_08305 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FG170_08315 ENOG4108ISG Major Facilitator FG170_08320 ENOG4105F1A Pyruvate formate-lyase FG170_08325 ENOG4105C6N Formate acetyltransferase FG170_08330 ENOG4105TMB Formate nitrite transporter FG170_08335 ENOG4105DDY UPF0142 protein ycaO FG170_08340 ENOG4105HDK L-asparaginase FG170_08345 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FG170_08350 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FG170_08355 ENOG4105CAT Cytidine monophosphate kinase FG170_08360 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FG170_08370 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FG170_08375 ENOG4105BZ1 (ABC) transporter FG170_08380 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FG170_08385 ENOG4105E32 cytoplasmic protein FG170_08390 ENOG4105VEQ Cold shock protein FG170_08395 ENOG4105VEQ Cold shock protein FG170_08400 ENOG4105T0Z Conserved Protein FG170_08405 ENOG4105W49 UPF0434 protein FG170_08410 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FG170_08415 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FG170_08420 ENOG4107S90 membrAne FG170_08425 ENOG4106371 Methyltransferase FG170_08430 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FG170_08435 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FG170_08440 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FG170_08445 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FG170_08450 ENOG4105EAQ (twin-arginine translocation) pathway signal FG170_08455 ENOG4105C5X domain protein FG170_08460 ENOG4105CGF Aromatic amino acid aminotransferase FG170_08470 ENOG4105C5S asparaginyl-tRNA synthetase FG170_08475 ENOG4107RH7 Nicotinate phosphoribosyltransferase FG170_08480 ENOG4105BZU Histidine kinase FG170_08485 ENOG4105CD8 aminopeptidase N FG170_08495 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FG170_08500 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FG170_08510 ENOG4108UZX fmn reductase FG170_08515 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FG170_08520 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FG170_08525 ENOG4105QVC MOSC domain-containing protein FG170_08530 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FG170_08535 ENOG4105C5H ABC transporter FG170_08540 ENOG4105F1S paraquat-inducible protein a FG170_08545 ENOG4105DY2 Paraquat-inducible protein b FG170_08550 ENOG4108Q2G (LipO)protein FG170_08555 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FG170_08560 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FG170_08570 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FG170_08575 ENOG4105DAN ATP-dependent protease FG170_08595 ENOG4108RZ1 DNA transformation protein FG170_08600 ENOG4105EM2 membrane FG170_08605 ENOG410901E Membrane FG170_08615 ENOG4108Z5K methylglyoxal synthase FG170_08625 ENOG4105K4P CoA-binding domain protein FG170_08630 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) FG170_08635 ENOG4105DR4 Methyltransferase FG170_08640 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FG170_08645 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FG170_08650 ENOG4108MN8 Membrane FG170_08670 ENOG4108MQF Chaperone FG170_08675 ENOG4105CW0 outer membrane usher protein FG170_08695 ENOG4108Z4X TRANSCRIPTIONal FG170_08700 ENOG4105ENT Efflux transporter rnd family, mfp subunit FG170_08705 ENOG4105BZS acriflavin resistance protein FG170_08720 ENOG4105CS1 NAD(P)H quinone oxidoreductase FG170_08730 ENOG4108MGI Transcriptional regulator FG170_08765 ENOG4105CSP Major Facilitator Superfamily FG170_08790 ENOG4105F27 Major Facilitator FG170_08795 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FG170_08805 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FG170_08815 ENOG4108U51 Universal stress protein FG170_08825 ENOG4105DG4 malate L-lactate dehydrogenase FG170_08830 ENOG4107QTZ amino acid FG170_08840 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FG170_08850 ENOG4105CTU Proline racemase FG170_08855 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FG170_08885 ENOG4105RA2 Membrane FG170_08890 ENOG4105XVG cytoplasmic protein FG170_08895 ENOG4105WH1 Two component transcriptional regulator luxr family FG170_08900 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FG170_08920 ENOG4105EZR dyp-type peroxidase family protein FG170_08935 ENOG4106NZI LysR family Transcriptional regulator FG170_08945 ENOG4107RSM transcriptional regulator FG170_08960 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FG170_09005 ENOG4105C4W S-formylglutathione hydrolase FG170_09015 ENOG4105D1H recombination factor protein RarA FG170_09020 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FG170_09080 ENOG4105W5Q DNA repair protein (RadC FG170_09280 ENOG4105NI8 Cytosine-specific methyltransferase FG170_09285 ENOG4108IYH Dna topoisomerase FG170_09290 ENOG4107YH6 single-stranded DNA-binding protein FG170_09325 ENOG4107QJE Chromosome Partitioning Protein FG170_09345 ENOG4105EMU Dehydrogenase FG170_09375 ENOG4105ZTC transcriptional activator, Ogr delta FG170_09465 ENOG4105KUS lysozyme FG170_09505 ENOG4105ED4 portal protein FG170_09520 ENOG4105VZ1 Replication Protein FG170_09585 ENOG4108IMY Transcriptional regulator FG170_09595 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FG170_09600 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FG170_09635 ENOG4105CR8 Transcriptional regulator FG170_09640 ENOG4105CSH Transporter FG170_09645 ENOG4105ETP RND efflux system, outer membrane lipoprotein FG170_09655 ENOG4105DJY efflux transporter, rnd family, mfp subunit FG170_09660 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FG170_09675 ENOG4105GSJ Inner membrane protein ylaC FG170_09695 ENOG4105DJ9 glucan biosynthesis protein FG170_09700 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FG170_09705 ENOG4105NAC (LipO)protein FG170_09715 ENOG4108W47 Acidic protein msyB FG170_09720 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FG170_09730 ENOG41080HT Transcriptional regulator, arsr family FG170_09745 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FG170_09750 ENOG4105DUX Transporter FG170_09755 ENOG4105C6X Major Facilitator FG170_09765 ENOG4105D1S lipid A biosynthesis FG170_09775 ENOG4105C72 UPF0176 protein FG170_09780 ENOG4108YYC ycei family FG170_09785 ENOG4105DS1 cytochrome b561 FG170_09790 ENOG4105DSF transport protein FG170_09815 ENOG4105PVA Biofilm formation regulatory protein BssS FG170_09830 ENOG4105EKE dihydroorotase FG170_09835 ENOG41067V3 Antibiotic biosynthesis monooxygenase FG170_09845 ENOG4105EI2 Pseudouridine synthase FG170_09855 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FG170_09860 ENOG4105VGS 50s ribosomal protein l32 FG170_09865 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FG170_09870 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FG170_09875 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FG170_09880 ENOG4105CHR reductase FG170_09885 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FG170_09890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FG170_09895 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FG170_09900 ENOG4105HHA aminodeoxychorismate lyase FG170_09905 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FG170_09910 ENOG4107QRG dna polymerase iii FG170_09915 ENOG4105F8V Hydrolase, tatD family FG170_09920 ENOG4105CI1 PTS System FG170_09930 ENOG4105KST dependent repressor FG170_09935 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FG170_09950 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FG170_09955 ENOG4105KVH Transcriptional regulator FG170_09965 ENOG4105K59 histidine triad (HIT) protein FG170_09970 ENOG41090DQ Lipoprotein FG170_09975 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FG170_09990 ENOG4105D0Y UPF0227 protein FG170_09995 ENOG4105CEP NADH dehydrogenase FG170_10000 ENOG4107MBR 17 kDa surface antigen FG170_10015 ENOG4105C1P efflux transporter, rnd family, mfp subunit FG170_10020 ENOG4105UEI Transcriptional Regulator AraC Family FG170_10050 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FG170_10055 ENOG4107SSZ Phosphatase FG170_10060 ENOG4107XHZ cytoplasmic chaperone TorD family protein FG170_10065 ENOG4108Q2J Inner membrane protein YebE FG170_10070 ENOG4105CUG Oligopeptidase b FG170_10075 ENOG4105UMD exodeoxyribonuclease X FG170_10085 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FG170_10090 ENOG4105HEI LysR family (Transcriptional regulator FG170_10105 ENOG4105MPK DNA polymerase III subunit theta FG170_10110 ENOG41090A1 ferritin FG170_10115 ENOG4105FXM Copper resistance protein FG170_10120 ENOG4108PNC copper resistance FG170_10125 ENOG4105NKT exported protein FG170_10155 ENOG4105VMP Transcriptional regulator FG170_10180 ENOG4108MRH transcriptional regulatory protein FG170_10185 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FG170_10200 ENOG4105C2J ABC transporter FG170_10205 ENOG4105CNN ABC, transporter FG170_10220 ENOG4105D01 (LipO)protein FG170_10235 ENOG41082SX arsR family transcriptional regulator FG170_10245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FG170_10260 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FG170_10270 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FG170_10275 ENOG4105C6X Major Facilitator FG170_10280 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FG170_10285 ENOG4105CGP Urocanate hydratase FG170_10345 ENOG4108IA2 Sodium pantothenate symporter FG170_10360 ENOG4105DYB Isoaspartyl dipeptidase FG170_10395 ENOG4105C3G gtp-binding protein FG170_10400 ENOG4105CHH sulfate transporter FG170_10405 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FG170_10410 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FG170_10415 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FG170_10420 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FG170_10425 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FG170_10440 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FG170_10450 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FG170_10455 ENOG4108YY7 Invasion gene expression up-regulator SirB FG170_10460 ENOG41063JG Transcriptional regulator FG170_10470 ENOG4105CHH sulfate transporter FG170_10475 ENOG41090KN UPF0303 protein FG170_10480 ENOG4105BZU Histidine kinase FG170_10485 ENOG4108JA2 transcriptioN-repair coupling factor FG170_10495 ENOG4105D60 lipoprotein releasing system transmembrane protein FG170_10505 ENOG4105D60 lipoprotein releasing system transmembrane protein FG170_10515 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FG170_10520 ENOG4107RUE extracellular solute-binding protein family 1 FG170_10535 ENOG4105CI1 PTS System FG170_10540 ENOG4105D38 putrescine abc transporter FG170_10545 ENOG4105F38 ABC transporter, permease FG170_10560 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FG170_10585 ENOG4105EZE Cupin 4 family protein FG170_10595 ENOG4105XJC Two component transcriptional regulator (Winged helix family FG170_10600 ENOG4108KD5 ADP-ribosylation crystallin J1 FG170_10605 ENOG4105FDP GntR family transcriptional regulator FG170_10620 ENOG4105D9U N-acetyltransferase FG170_10625 ENOG4107QTF adenylosuccinate lyase FG170_10630 ENOG41075W9 High frequency lysogenization protein HflD homolog FG170_10640 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FG170_10655 ENOG4108R99 pseudouridine synthase FG170_10660 ENOG4108HMX isocitrate dehydrogenase (NADP) FG170_10670 ENOG4108RW8 Universal stress protein F FG170_10675 ENOG4105M5B (LipO)protein FG170_10680 ENOG4105M5B (LipO)protein FG170_10685 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FG170_10745 ENOG4105CIB oxidoreductase Domain protein FG170_10775 ENOG4105VEQ Cold shock protein FG170_10785 ENOG4105CHJ isochorismatase hydrolase FG170_10790 ENOG4108M6U Universal stress protein A FG170_10795 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FG170_10805 ENOG4105C26 Dehydrogenase FG170_10810 ENOG4107VRI Transcriptional regulator FG170_10815 ENOG4108Z86 Glutamine amidotransferase FG170_10820 ENOG4105CFQ glutamine synthetase FG170_10830 ENOG4105CUB amino acid FG170_10855 ENOG4105DRB nucleoside-specific channel-forming protein FG170_10870 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) FG170_10880 ENOG4105CI2 imidazolone-5-propionate hydrolase FG170_10885 ENOG4105CZE histidine utilization repressor FG170_10890 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FG170_10900 ENOG4106NDP Transcriptional regulator FG170_10910 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FG170_10915 ENOG4105CSH Transporter FG170_10935 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FG170_10970 ENOG4105WT8 Protein of unknown function (DUF1480) FG170_11015 ENOG4105DY2 Paraquat-inducible protein b FG170_11020 ENOG4105H2K paraquat-inducible protein a FG170_11025 ENOG4108ZGC gaf domain protein FG170_11030 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FG170_11035 ENOG4105CN1 protease FG170_11040 ENOG4105D0M Protease HtpX homolog FG170_11060 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FG170_11075 ENOG4105CY5 solute-binding protein FG170_11080 ENOG4106S9K Transcriptional regulator FG170_11095 ENOG4108ETY sodium dicarboxylate symporter FG170_11100 ENOG4107K5X Membrane-bound metal-dependent hydrolase FG170_11105 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FG170_11115 ENOG4107PN8 YfeABCD locus regulator FG170_11120 ENOG4105FGM Fructosamine kinase FG170_11125 ENOG4105CC5 ABC transporter FG170_11130 ENOG4105CC5 ABC transporter FG170_11140 ENOG4105DSE periplasmic solute binding protein FG170_11145 ENOG4105P10 Uncharacterized protein ydiZ FG170_11150 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FG170_11170 ENOG4105C44 Serine transporter FG170_11180 ENOG41082NP Multiple antibiotic resistance FG170_11200 ENOG4105C22 threonyL-tRNA synthetase FG170_11210 ENOG41082NX 50s ribosomal protein l35 FG170_11215 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FG170_11225 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FG170_11245 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) FG170_11250 ENOG4108V06 Glutathione peroxidase FG170_11255 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FG170_11265 ENOG4105CKK Glycosyl transferase, family 2 FG170_11275 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FG170_11280 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FG170_11285 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FG170_11290 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FG170_11295 ENOG4108QBX (LipO)protein FG170_11300 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FG170_11320 ENOG4105EHG Permease protein FG170_11335 ENOG4107ENK receptor FG170_11340 ENOG4107F3C Hemin uptake protein FG170_11345 ENOG4108V06 Glutathione peroxidase FG170_11350 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FG170_11355 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FG170_11375 ENOG4105IPI Membrane FG170_11380 ENOG4105CQB FAD linked oxidase domain protein FG170_11385 ENOG4105KA0 thioesterase Superfamily protein FG170_11395 ENOG4108Z4V iron-sulfur cluster assembly FG170_11400 ENOG4105DIW FeS assembly protein SUFB FG170_11405 ENOG4105C3K feS assembly ATPase SufC FG170_11410 ENOG4105JRK feS assembly protein SufD FG170_11415 ENOG4105C9B Cysteine desulfurase FG170_11420 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FG170_11425 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FG170_11435 ENOG4105CA9 Pyruvate kinase FG170_11465 ENOG4108R6K riboflavin synthase, subunit alpha FG170_11475 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FG170_11485 ENOG4105F52 Transcriptional regulator FG170_11490 ENOG4105ETE Transcriptional regulator (LacI family FG170_11500 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FG170_11510 ENOG4105M2J Glutaredoxin FG170_11520 ENOG4108UYE Lactoylglutathione lyase FG170_11525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FG170_11530 ENOG4108WUH Transcriptional regulator, TetR family FG170_11535 ENOG4105DIJ Phosphoethanolamine transferase FG170_11550 ENOG4105XZD Fe-S protein FG170_11555 ENOG4107RGM aldo keto reductase FG170_11565 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FG170_11570 ENOG4105DSW Fusaric acid resistance protein FG170_11575 ENOG4105Y49 secretion protein, HlyD family FG170_11585 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) FG170_11590 ENOG4108XTF Outer Membrane Lipoprotein FG170_11595 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FG170_11605 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FG170_11610 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FG170_11620 ENOG4108K3A Glutathione S-transferase FG170_11630 ENOG4108ZR5 Conserved Protein FG170_11655 ENOG4105KME endoribonuclease L-psp FG170_11670 ENOG4105DKK Benzoate FG170_11675 ENOG4108JCI Transcriptional regulator FG170_11685 ENOG4105DUX Transporter FG170_11690 ENOG4105CSM endonuclease III FG170_11700 ENOG4108UQQ Electron transport complex FG170_11710 ENOG4105UEI Transcriptional Regulator AraC Family FG170_11720 ENOG4108R3D Electron transport complex FG170_11725 ENOG4105DGN Electron transport complex FG170_11730 ENOG4105M9B inner membrane protein ydgK FG170_11735 ENOG4105D9R oxidoreductase FG170_11740 ENOG4105DHU Bile acid FG170_11750 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FG170_11760 ENOG4107VIJ nudix hydrolase FG170_11770 ENOG4105C87 Aminotransferase class I and II FG170_11775 ENOG4105CI1 PTS System FG170_11780 ENOG4107P2S Transcriptional regulator FG170_11785 ENOG4105ETT transcriptional Regulator, LysR family FG170_11795 ENOG410642W LysR family Transcriptional regulator FG170_11805 ENOG4106J39 exported protein FG170_11810 ENOG4105EIP mannose-6-phosphate isomerase FG170_11820 ENOG4105C9Q fumarate hydratase class II FG170_11830 ENOG4108MP6 LysR family Transcriptional regulator FG170_11835 ENOG4105D29 Helix-turn-helix type 11 domain protein FG170_11845 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) FG170_11850 ENOG4105D17 glycoside hydrolase, family 3 domain protein FG170_11855 ENOG4105F32 YngK protein FG170_11860 ENOG4105D94 Major Facilitator Superfamily FG170_11865 ENOG4106NZI LysR family Transcriptional regulator FG170_11870 ENOG4105DAG ROK family FG170_11875 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FG170_11885 ENOG4108Z4X TRANSCRIPTIONal FG170_11895 ENOG4108IJ8 ABC transporter FG170_11900 ENOG4108IJ8 ABC transporter FG170_11905 ENOG4108IJ8 ABC transporter FG170_11910 ENOG4105E90 ABC transporter FG170_11915 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FG170_11920 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component FG170_11925 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_11930 ENOG4105KBG Protein of unknown function (DUF1161) FG170_11935 ENOG4105M5Q UPF0482 protein FG170_11940 ENOG4105KK4 UPF0060 membrane protein FG170_11945 ENOG4105EMU Dehydrogenase FG170_11960 ENOG4108S3W Anti-feci sigma factor, fecr FG170_11965 ENOG4108SF5 RNA Polymerase FG170_11975 ENOG4107QUY Guanine deaminase FG170_11985 ENOG4105EXG Transcriptional regulator FG170_11990 ENOG4108MBX Secretion Protein FG170_11995 ENOG4108JJA ABC, transporter FG170_12015 ENOG4105CEY Amp-dependent synthetase and ligase FG170_12020 ENOG4105CEY Amp-dependent synthetase and ligase FG170_12040 ENOG4105DGW oligopeptidase A FG170_12045 ENOG410642W LysR family Transcriptional regulator FG170_12055 ENOG4105CSP Major Facilitator Superfamily FG170_12060 ENOG4108UAU isochorismatase FG170_12065 ENOG4105RE0 Asp Glu hydantoin racemase FG170_12075 ENOG4105MSY salicylate hydroxylase FG170_12085 ENOG4108VHT MarR family transcriptional regulator FG170_12090 ENOG4108XHQ (2Fe-2S)-binding domain protein FG170_12150 ENOG4105C5Y PTS System FG170_12155 ENOG4105CS2 ec 3.2.1.21 FG170_12160 ENOG4105CID antiterminator FG170_12195 ENOG4105CPT Alpha beta hydrolase FG170_12220 ENOG4107TV1 YD repeat protein FG170_12240 ENOG4105JAB phenazine biosynthesis protein, phzf family FG170_12250 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FG170_12270 ENOG4105C6X Major Facilitator FG170_12280 ENOG4105PMV Membrane FG170_12290 ENOG4105CJN penicillin-binding protein FG170_12305 ENOG4105C8Q Methyl-accepting chemotaxis FG170_12310 ENOG41061RM osmotically inducible lipoprotein FG170_12325 ENOG410680R Protein of unknown function (DUF2592) FG170_12330 ENOG4105CDA abc transporter atp-binding protein FG170_12335 ENOG4105EAD ABC transporter FG170_12345 ENOG4105CPU Monooxygenase FG170_12350 ENOG4108PGP mmge prpd family protein FG170_12360 ENOG4107S1E Beta-lactamase FG170_12365 ENOG4105F27 Major Facilitator FG170_12375 ENOG4105E98 transcriptional regulator DeoR family FG170_12380 ENOG4105D9R oxidoreductase FG170_12385 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_12410 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FG170_12415 ENOG4108TEB UPF0114 protein FG170_12420 ENOG4105EQ0 Major Facilitator superfamily FG170_12425 ENOG4105HEI LysR family (Transcriptional regulator FG170_12455 ENOG4105DQ4 alcohol dehydrogenase FG170_12460 ENOG4105C26 Dehydrogenase FG170_12465 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FG170_12480 ENOG4105BZU Histidine kinase FG170_12495 ENOG4105DRR Transcriptional regulator, GntR family FG170_12505 ENOG4108MXF Alpha Beta Hydrolase FG170_12525 ENOG4105ETS cytosine purines uracil thiamine allantoin FG170_12545 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) FG170_12550 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FG170_12560 ENOG4108IGT Dipeptidase FG170_12565 ENOG41090VV Protein of unknown function (DUF2846) FG170_12570 ENOG4108PTX LysR family Transcriptional regulator FG170_12590 ENOG4105DY8 decarboxylase FG170_12595 ENOG4108JPW Aminotransferase FG170_12600 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FG170_12605 ENOG4105W1Y Transcriptional regulator FG170_12620 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FG170_12625 ENOG4105BZU Histidine kinase FG170_12640 ENOG4105ETT transcriptional Regulator, LysR family FG170_12685 ENOG4107RZC phospholipase d FG170_12690 ENOG4105K63 Thioredoxin FG170_12700 ENOG41080HT Transcriptional regulator, arsr family FG170_12710 ENOG4105CPQ Dehydrogenase FG170_12720 ENOG4105CIB oxidoreductase Domain protein FG170_12745 ENOG4105RHY Pfam:UPF0157 FG170_12755 ENOG4108UIN ybak prolyl-trna synthetase associated region FG170_12785 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF FG170_12790 ENOG410829K Lysine exporter protein (Lyse ygga) FG170_12795 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FG170_12800 ENOG4105KVH Transcriptional regulator FG170_12825 ENOG4105E0K tonB-dependent siderophore receptor FG170_12830 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FG170_12840 ENOG4108SGR YheO domain-containing protein FG170_12850 ENOG4105D82 Glutamate dehydrogenase FG170_12860 ENOG4108Z0Z intracellular protease Pfpi family FG170_12905 ENOG4105BZS acriflavin resistance protein FG170_12910 ENOG4105C1P efflux transporter, rnd family, mfp subunit FG170_12925 ENOG4105DWY Agmatine deiminase FG170_12930 ENOG4105ETT transcriptional Regulator, LysR family FG170_12945 ENOG410804X Transcriptional regulator FG170_12960 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FG170_12965 ENOG4105ENY Ethanolamine utilization protein eutH FG170_12995 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FG170_13000 ENOG4108XHQ (2Fe-2S)-binding domain protein FG170_13020 ENOG4108Q3X Transcriptional regulator FG170_13025 ENOG4105CS2 ec 3.2.1.21 FG170_13045 ENOG4105KCV RNA signal recognition particle 4.5S RNA FG170_13050 ENOG4105BZU Histidine kinase FG170_13070 ENOG4105EGS Mechanosensitive ion channel FG170_13075 ENOG4105C5H ABC transporter FG170_13085 ENOG4105ECY inositol monophosphatase FG170_13090 ENOG41076HS cation diffusion facilitator family transporter FG170_13105 ENOG4105CJW magnesium transporter FG170_13110 ENOG4107QSI ABC, transporter FG170_13280 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FG170_13290 ENOG4108ZG0 Ompa motb domain protein FG170_13320 ENOG4105DXC membrane FG170_13370 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FG170_13375 ENOG4105C0Z ABC transporter FG170_13380 ENOG4108IV0 ABC, transporter FG170_13415 ENOG4105CJ3 phosphate transporter FG170_13420 ENOG4105CSR polyphosphate kinase 2 FG170_13430 ENOG41061WM D-Alanyl-D-Alanine FG170_13450 ENOG41089BK Glutamine amido-transferase FG170_13460 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) FG170_13485 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FG170_13490 ENOG4105DRS transport system, permease FG170_13495 ENOG4108IJ9 (ABC) transporter FG170_13500 ENOG4105DDC Oxidoreductase domain protein FG170_13515 ENOG4105E70 isomerase FG170_13520 ENOG4105D2N Aldolase FG170_13530 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FG170_13540 ENOG4105Q9Y Universal stress protein FG170_13555 ENOG4105C5D exported protein FG170_13565 ENOG4105D5Q Arginine ornithine antiporter FG170_13585 ENOG410642E Short chain dehydrogenase FG170_13590 ENOG4107EXC regulatoR FG170_13595 ENOG4105JJR Histidine kinase FG170_13600 ENOG4105CTD carboxy-peptidase FG170_13615 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FG170_13625 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FG170_13635 ENOG4105WXT Conserved Protein FG170_13640 ENOG410689M (LipO)protein FG170_13650 ENOG4107YNJ LysR family Transcriptional regulator FG170_13660 ENOG4105C5I Dehydrogenase FG170_13665 ENOG41090X5 Heat shock protein hslJ FG170_13680 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FG170_13690 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FG170_13720 ENOG4107QSI ABC, transporter FG170_13730 ENOG4105KXI murein peptide amidase A FG170_13735 ENOG4107S8C mandelate racemase muconate lactonizing FG170_13740 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FG170_13760 ENOG4105NNG Peripheral inner membrane phage-shock protein FG170_13765 ENOG4105FM1 phage shock protein C FG170_13770 ENOG4105YYT phage shock protein B FG170_13800 ENOG4107UHU Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FG170_13805 ENOG4108J59 Extracellular solute-binding protein, family 5 FG170_13810 ENOG4108I5W peptide transport system, permease protein FG170_13815 ENOG4108EU3 peptide transport system, permease FG170_13820 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FG170_13825 ENOG4108JQ2 peptide transport system atp-binding protein FG170_13835 ENOG4105Q4T oxidoreductase FG170_13840 ENOG4105DUM transcriptional regulator, lysR family FG170_13845 ENOG4105DZ1 carboxypeptidase FG170_13850 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FG170_13855 ENOG4105EGI Transcriptional regulator FG170_13865 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FG170_13875 ENOG4105CH2 amidohydrolase FG170_13880 ENOG4105D22 carbon starvation protein FG170_13885 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FG170_13890 ENOG4105F1A Pyruvate formate-lyase FG170_13900 ENOG4105N2W Transcriptional regulator FG170_13915 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FG170_13930 ENOG4105CFV Tetratricopeptide repeat protein FG170_13935 ENOG4105Q4A inner membrane protein yciS FG170_13940 ENOG4105CHR reductase FG170_13945 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FG170_13950 ENOG4105CNN ABC, transporter FG170_13955 ENOG4105C2J ABC transporter FG170_13965 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FG170_13970 ENOG4108R85 Short chain dehydrogenase FG170_13975 ENOG4108IUS Transketolase FG170_13980 ENOG4108HHA Transketolase FG170_13990 ENOG4105EYK Phosphatidylglycerophosphatase B FG170_14000 ENOG4107QM5 aconitate hydratase FG170_14015 ENOG4107R11 Transcriptional regulator FG170_14025 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FG170_14030 ENOG4105RKX Protein of unknown function (DUF2498) FG170_14035 ENOG4105ERU peptidase FG170_14040 ENOG4105UBK short-chain dehydrogenase reductase FG170_14045 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FG170_14050 ENOG4105FE9 pseudouridine synthase FG170_14065 ENOG4107RTD sua5 ycio yrdc ywlc family protein FG170_14070 ENOG4105DB7 PHP domain protein FG170_14085 ENOG4107QYG anthranilate phosphoribosyltransferase FG170_14090 ENOG4105DK0 Indole-3-glycerol phosphate synthase FG170_14095 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FG170_14100 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FG170_14110 ENOG4105EIF outer membrane protein W FG170_14115 ENOG4105PI0 Ferredoxin FG170_14120 ENOG4108S3I UPF0259 membrane protein FG170_14130 ENOG4107835 probably involved in intracellular septation (By similarity) FG170_14135 ENOG4105NAU thioesterase Superfamily protein FG170_14140 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FG170_14150 ENOG4105WPN DNA integration recombination invertion protein FG170_14155 ENOG4105K9H YciI-like protein FG170_14160 ENOG4107NQ8 LysR family Transcriptional regulator FG170_14170 ENOG4105ETE Transcriptional regulator (LacI family FG170_14185 ENOG4105CMG Carbohydrate kinase FG170_14190 ENOG4105C2J ABC transporter FG170_14195 ENOG4105CNN ABC, transporter FG170_14200 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FG170_14215 ENOG4108RMU ferritin dps family protein FG170_14225 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FG170_14230 ENOG4108W5H UPF0263 protein FG170_14235 ENOG4108JQ7 (ABC) transporter FG170_14240 ENOG4105C3U ABC transporter FG170_14245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FG170_14250 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FG170_14255 ENOG4107QSI ABC, transporter FG170_14260 ENOG4108J59 Extracellular solute-binding protein, family 5 FG170_14265 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FG170_14270 ENOG4108EKI Dehydrogenase FG170_14275 ENOG4107104 thymidine kinase FG170_14290 ENOG4105C6Y Udp-glucose 6-dehydrogenase FG170_14295 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FG170_14300 ENOG4105I93 response regulator FG170_14310 ENOG4105K5B UPF0225 protein FG170_14315 ENOG4105CIY formyltetrahydrofolate deformylase FG170_14330 ENOG4108URH decarboxylase FG170_14335 ENOG4105CGK Exodeoxyribonuclease III FG170_14340 ENOG4105M6F mutator MutT protein FG170_14345 ENOG4105MTM Protein of unknown function (DUF1496) FG170_14365 ENOG41069NU Nitroreductase FG170_14375 ENOG4105HDK L-asparaginase FG170_14380 ENOG4108RWI nicotinamidase FG170_14390 ENOG4105VUT cytoplasmic protein FG170_14395 ENOG4105E0X reductase FG170_14400 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FG170_14405 ENOG4105DSB aldose 1-epimerase FG170_14410 ENOG4105GNX MltA-interacting MipA family protein FG170_14420 ENOG4105CYN Serine protein kinase FG170_14425 ENOG4106AKX UPF0229 protein FG170_14465 ENOG4105CNH Multidrug resistance protein MdtL FG170_14470 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FG170_14485 ENOG4108MEK Metal-binding protein YodA FG170_14490 ENOG4105ED1 spovr family FG170_14495 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FG170_14500 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FG170_14505 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FG170_14515 ENOG4108ZZ3 UPF0260 protein FG170_14520 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FG170_14525 ENOG4105CVE Lytic murein transglycosylase FG170_14530 ENOG4105VNG YcgL domain-containing protein FG170_14535 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FG170_14540 ENOG4107QMS site-determining protein FG170_14545 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FG170_14550 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FG170_14555 ENOG4105CEY Amp-dependent synthetase and ligase FG170_14560 ENOG4105Y4Z Outer Membrane Lipoprotein FG170_14570 ENOG4105DVT helicase FG170_14575 ENOG4105M4H endoribonuclease L-psp FG170_14580 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) FG170_14585 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FG170_14590 ENOG4108UHU Aldolase FG170_14595 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FG170_14600 ENOG4106KNT transcriptional regulator FG170_14605 ENOG4105CA9 Pyruvate kinase FG170_14615 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FG170_14620 ENOG4105DR5 peptidase FG170_14625 ENOG4105NXV High-affinity zinc uptake system protein FG170_14630 ENOG4105FDK ABC transporter FG170_14635 ENOG4105FAV ABC, transporter FG170_14640 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FG170_14645 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FG170_14650 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FG170_14655 ENOG4105CDY transcriptional regulatory protein FG170_14660 ENOG4108TIT dATP pyrophosphohydrolase FG170_14665 ENOG4105C9M aspartyl-trna synthetase FG170_14675 ENOG4105D3W isochorismatase FG170_14685 ENOG4105WJG Glutathione FG170_14690 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FG170_14695 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FG170_14720 ENOG4106N3A copper homeostasis protein cutc FG170_14725 ENOG4105C87 Aminotransferase class I and II FG170_14730 ENOG4106ZCM YecM protein FG170_14740 ENOG4105CJR Integral membrane protein (MviN FG170_14745 ENOG4105EP9 oxidoreductase FG170_14750 ENOG4108YXG UPF0502 protein FG170_14755 ENOG4105D9U N-acetyltransferase FG170_14770 ENOG4105E9S glutaredoxin 2 FG170_14780 ENOG4105F3T (LipO)protein FG170_14790 ENOG4105N5Z UPF0267 protein FG170_14795 ENOG4105X2V dna damage-inducible protein FG170_14800 ENOG4105C1J atp-dependent rna helicase FG170_14805 ENOG4105VEQ Cold shock protein FG170_14810 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FG170_14815 ENOG4105X5C UPF0181 protein FG170_14820 ENOG4105K64 Glycosyl transferase, family 2 FG170_14830 ENOG4105P8F nudix hydrolase FG170_14835 ENOG4105EJQ L-serine dehydratase FG170_14840 ENOG4107XTP (EAL) domain protein FG170_14845 ENOG4105EE5 Membrane protein terC FG170_14855 ENOG4105ETZ PTS System FG170_14860 ENOG4105F3R pts system mannose fructose sorbose family iid FG170_14865 ENOG4108NK4 UPF0266 membrane protein FG170_14870 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FG170_14875 ENOG4105DHI Methyltransferase FG170_14880 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FG170_14885 ENOG4105VEQ Cold shock protein FG170_14890 ENOG410610J Protein of unknown function (DUF2627) FG170_14905 ENOG4105C85 amino acid FG170_14925 ENOG41064PC FG170_14935 ENOG4105TIK FG170_14940 ENOG4105N4N Protein of unknown function (DUF2766) FG170_14945 ENOG4105XH3 FG170_14960 ENOG4105EUB pirin domain protein FG170_14965 ENOG4109066 lysm domain bon superfamily protein FG170_14970 ENOG4105UVW uncharacterized protein yebW FG170_14990 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FG170_14995 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FG170_15005 ENOG4105F4X arginine FG170_15010 ENOG4105C8Y Acetylornithine aminotransferase FG170_15020 ENOG4108JQ7 (ABC) transporter FG170_15025 ENOG4105C3U ABC transporter FG170_15045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FG170_15050 ENOG4105C4M (Ubiquinol oxidase) subunit I FG170_15055 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FG170_15105 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FG170_15110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FG170_15115 ENOG41076YT nitrate reductase, gamma subunit FG170_15120 ENOG4105R3A Nitrate reductase FG170_15125 ENOG4108IUE nitrate reductase beta subunit FG170_15170 ENOG4105D75 Capsular exopolysaccharide family FG170_15175 ENOG4105DAY polysaccharide export protein FG170_15180 ENOG4105ESV Glycosyl transferase, family 4 FG170_15185 ENOG4105DMT epimerase dehydratase FG170_15190 ENOG4108M3R transcriptional activator CadC FG170_15195 ENOG4105DQQ Major facilitator superfamily MFS_1 FG170_15200 ENOG4105BZU Histidine kinase FG170_15205 ENOG4105WH1 Two component transcriptional regulator luxr family FG170_15215 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FG170_15230 ENOG4108JQ7 (ABC) transporter FG170_15235 ENOG4105C3U ABC transporter FG170_15240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FG170_15245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FG170_15255 ENOG4107R11 Transcriptional regulator FG170_15260 ENOG4108NH8 Cation transport protein FG170_15265 ENOG4105WS7 Cation transport regulator FG170_15275 ENOG4105EWV Sodium calcium exchanger membrane region FG170_15285 ENOG4105D5M phosphate starvation-inducible protein FG170_15305 ENOG4105CK7 Sodium proline symporter FG170_15310 ENOG4105C26 Dehydrogenase FG170_15320 ENOG4105CDA abc transporter atp-binding protein FG170_15325 ENOG4105E5Q amino acid AbC transporter FG170_15330 ENOG4105EAB amino acid AbC transporter FG170_15335 ENOG4105K6H D-cysteine desulfhydrase FG170_15340 ENOG4108M9K flagella biosynthesis protein FliZ FG170_15360 ENOG4105DTS flagellar hook-associated FG170_15365 ENOG4105MQ3 flagellar protein FliS FG170_15370 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) FG170_15380 ENOG4105CC0 LysR family Transcriptional regulator FG170_15395 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FG170_15400 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FG170_15415 ENOG4108JIR Flagellum-specific ATP synthase FG170_15420 ENOG4105GSA Flagellar export protein flij FG170_15425 ENOG4105WF4 Flagellar hook-length control protein FG170_15430 ENOG4107ZI8 flagellar basal body-associated protein flil FG170_15435 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FG170_15440 ENOG4105DD5 Flagellar motor switch protein FG170_15450 ENOG4105CN7 Flagellar biosynthetic protein FliP FG170_15455 ENOG4105VS8 Flagellar biosynthetic protein fliq FG170_15460 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FG170_15465 ENOG4105DTJ flagellar hook-associated protein FG170_15490 ENOG4105CGA flagellar basal-body rod protein FlgG FG170_15495 ENOG4108KPB Flagellar basal-body rod protein FlgF FG170_15500 ENOG4105BZE flagellar hook protein, FlgE FG170_15505 ENOG4105W00 Flagellar hook capping protein FG170_15510 ENOG4108ZC9 flagellar basal-body rod protein flgc FG170_15520 ENOG4105CKS Flagella basal body P-ring formation protein flgA FG170_15525 ENOG4105M9M anti-sigma28 factor FlgM FG170_15530 ENOG4105QVD Flagella synthesis protein FlgN FG170_15550 ENOG4105D7B Flagellar biosynthesis protein flha FG170_15555 ENOG4105D00 flagellar biosynthetic protein flhB FG170_15560 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FG170_15565 ENOG4108VYJ response regulator receiver protein FG170_15580 ENOG4105C8Q Methyl-accepting chemotaxis FG170_15585 ENOG4106IKR FG170_15605 ENOG4108T86 baseplate J family protein FG170_15615 ENOG4105PZ7 Baseplate assembly protein FG170_15635 ENOG41062PQ Mu-like prophage FluMu protein gp41 FG170_15645 ENOG4105TKZ Tail Sheath FG170_15675 ENOG4105EFV Major head subunit FG170_15695 ENOG4105CF2 Mu-like prophage FluMu protein GP28 FG170_15700 ENOG4108Z6H mu-like prophage Flumu protein gp27 FG170_15755 ENOG41065S5 FG170_15785 ENOG4108WTW DNA transposition protein FG170_15790 ENOG4106YXT transposase FG170_15795 ENOG4105HVQ Regulatory factor of maltose metabolism FG170_15805 ENOG4105C8Q Methyl-accepting chemotaxis FG170_15810 ENOG4105C8Q Methyl-accepting chemotaxis FG170_15815 ENOG4108V3W Chemotaxis protein, CheW FG170_15820 ENOG4105CBS Chea signal transduction histidine kinase FG170_15825 ENOG4105ER2 Ompa motb domain protein FG170_15830 ENOG4107RD7 Flagellar Motor Protein, MotA FG170_15845 ENOG4105QZ5 OriC-binding nucleoid-associated protein FG170_15850 ENOG4108VA4 Universal stress protein FG170_15855 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FG170_15920 ENOG4106VK6 Flagellar motor protein FG170_15950 ENOG4108WC9 type VI secretion system effector, hcp1 family FG170_16005 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FG170_16015 ENOG4105CS6 Rhs element vgr protein FG170_16020 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FG170_16025 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FG170_16080 ENOG4105C2C drug resistance transporter, Bcr CflA FG170_16100 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FG170_16105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FG170_16115 ENOG4108S3W Anti-feci sigma factor, fecr FG170_16120 ENOG4108SF5 RNA Polymerase FG170_16125 ENOG4105X58 receptor FG170_16130 ENOG4105KT5 UmuD protein FG170_16170 ENOG4105CBN LysR family transcriptional regulator FG170_16185 ENOG4105FFC UPF0187 protein FG170_16190 ENOG4105EZR dyp-type peroxidase family protein FG170_16195 ENOG4105K89 arsenate reductase FG170_16210 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FG170_16230 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FG170_16235 ENOG4105KT7 mgtC SapB transporter FG170_16245 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F FG170_16250 ENOG4108MGI Transcriptional regulator FG170_16255 ENOG4105DY8 decarboxylase FG170_16270 ENOG4105VZF DsrB protein FG170_16275 ENOG4105VEQ Cold shock protein FG170_16300 ENOG410642W LysR family Transcriptional regulator FG170_16305 ENOG4105VP5 Bacterial protein of unknown function (DUF937) FG170_16310 ENOG4105Y3U Transglycosylase-associated protein FG170_16320 ENOG4105D1S lipid A biosynthesis FG170_16325 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FG170_16345 ENOG4105DXM phenylacetic acid degradation protein FG170_16350 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FG170_16355 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FG170_16360 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FG170_16365 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FG170_16370 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FG170_16375 ENOG4105E39 Enoyl-CoA hydratase FG170_16380 ENOG4108UKI Enoyl-CoA hydratase FG170_16385 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FG170_16390 ENOG4108ZJI phenylacetic acid degradation protein FG170_16395 ENOG4105CHU acetyl-coa acetyltransferase FG170_16400 ENOG4105DZS Phenylacetate-CoA ligase FG170_16405 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FG170_16410 ENOG4108Z0R Transferase FG170_16415 ENOG4105C85 amino acid FG170_16435 ENOG4105CC0 LysR family Transcriptional regulator FG170_16455 ENOG4105C26 Dehydrogenase FG170_16475 ENOG4105EQ2 LysR family Transcriptional regulator FG170_16480 ENOG4105CPC Aldo Keto reductase FG170_16485 ENOG4105CHB tonB-dependent Receptor FG170_16490 ENOG4105DZG Dehydrogenase FG170_16505 ENOG4105UQX Mate efflux family protein FG170_16510 ENOG4105XQF Lipoprotein FG170_16535 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FG170_16545 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FG170_16575 ENOG4105ETU transcriptional activator (TenA FG170_16580 ENOG4108YI8 ABC transporter FG170_16585 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FG170_16590 ENOG4107Z6I Thiamine biosynthesis protein FG170_16600 ENOG4107RES phosphoglycerol transferase I FG170_16605 ENOG4105FYV Amp nucleosidase FG170_16635 ENOG4108T9Y Inner membrane protein ydcZ FG170_16640 ENOG4108Z7F N-acetyltransferase FG170_16650 ENOG410900S Protein of unknown function (DUF2623) FG170_16660 ENOG4105W8I Transcriptional regulator FG170_16670 ENOG4107T8P acyl-Coa dehydrogenase FG170_16675 ENOG4107QNK )-transporter FG170_16685 ENOG4108UMI ABC transporter, permease FG170_16705 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FG170_16710 ENOG4108JU7 Transcriptional regulator FG170_16715 ENOG4107XBN GntR Family Transcriptional Regulator FG170_16735 ENOG4105CHR reductase FG170_16740 ENOG4105CHR reductase FG170_16760 ENOG4105DKP glycosyl transferase, family 9 FG170_16785 ENOG4108JQ6 ABC transporter FG170_16815 ENOG4105EXG Transcriptional regulator FG170_16820 ENOG4105CF1 Alkylated DNA repair protein FG170_16825 ENOG4105DTR rard protein FG170_16830 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FG170_16835 ENOG4105E4F Isochorismate synthase FG170_16855 ENOG4105D6F Phosphatase FG170_16860 ENOG4107QPK )-transporter FG170_16865 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FG170_16875 ENOG4105CHY citrate lyase, alpha FG170_16880 ENOG4105CI0 Citrate lyase FG170_16885 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) FG170_16890 ENOG4105DUA (citrate (pro-3S)-lyase ligase FG170_16895 ENOG4106YYS transcriptional regulatory protein FG170_16900 ENOG4105CNT hydrolase family 2 FG170_16910 ENOG4105E1F short-chain dehydrogenase reductase FG170_16915 ENOG4105CF7 AraC family transcriptional regulator FG170_16925 ENOG4105ETT transcriptional Regulator, LysR family FG170_16930 ENOG4107WYG Transcriptional regulator, luxr family FG170_16940 ENOG4105DIK (ABC) transporter FG170_16945 ENOG4105EHG Permease protein FG170_16960 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_16965 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FG170_16990 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FG170_17010 ENOG4105EA8 2-Nitropropane dioxygenase FG170_17055 ENOG4108IV0 ABC, transporter FG170_17060 ENOG4105C0Z ABC transporter FG170_17065 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FG170_17070 ENOG4105C32 Amino acid ABC transporter (Permease) FG170_17100 ENOG4105CSH Transporter FG170_17110 ENOG4105F04 LysR family Transcriptional regulator FG170_17115 ENOG41080IJ Diacylglycerol kinase FG170_17135 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FG170_17140 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FG170_17150 ENOG4108NDC ATP-binding protein yghS FG170_17155 ENOG4106FPV ATP-binding protein YghR FG170_17160 ENOG4108S55 polysaccharide biosynthesis protein FG170_17170 ENOG4108UUE Transcriptional regulator FG170_17175 ENOG4108M8S permease YjgP YjgQ family protein FG170_17230 ENOG4105FKQ transcriptional regulator FG170_17235 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FG170_17240 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FG170_17245 ENOG4105CMG Carbohydrate kinase FG170_17250 ENOG4105CNN ABC, transporter FG170_17260 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FG170_17265 ENOG4105CPQ Dehydrogenase FG170_17270 ENOG41090HJ UPF0265 protein FG170_17275 ENOG4105DR8 Membrane FG170_17280 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FG170_17305 ENOG4105CJB Exodeoxyribonuclease I FG170_17310 ENOG4105CUB amino acid FG170_17320 ENOG4105CFQ glutamine synthetase FG170_17325 ENOG4107VRI Transcriptional regulator FG170_17330 ENOG4105C2J ABC transporter FG170_17335 ENOG4105CNN ABC, transporter FG170_17340 ENOG4105D05 Receptor FG170_17355 ENOG4105EHG Permease protein FG170_17360 ENOG4105BZU Histidine kinase FG170_17365 ENOG4108IQI permease FG170_17370 ENOG4105DUM transcriptional regulator, lysR family FG170_17380 ENOG4105HMI Membrane FG170_17385 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FG170_17395 ENOG4105DM4 PTS System FG170_17400 ENOG4105DE4 1-phosphofructokinase FG170_17410 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FG170_17415 ENOG4105CUW cytochrome C-TYPE protein FG170_17420 ENOG4107QY8 reductase FG170_17430 ENOG4105KRS Proteinase inhibitor FG170_17440 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FG170_17445 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FG170_17450 ENOG4105DEI Mannitol dehydrogenase FG170_17460 ENOG4105CKI cobalamin synthesis protein FG170_17465 ENOG41076MN Phosphoesterase, PA-phosphatase related FG170_17475 ENOG4107TT5 NLP P60 protein FG170_17480 ENOG4105CXC rtn protein FG170_17485 ENOG4105E43 Extracellular solute-binding protein, family 5 FG170_17490 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FG170_17495 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FG170_17500 ENOG4108JQ5 ABC transporter FG170_17505 ENOG4105HG6 FG170_17510 ENOG4105C2C drug resistance transporter, Bcr CflA FG170_17515 ENOG4105I08 Pseudouridine synthase FG170_17520 ENOG4105CFI type iii restriction protein res subunit FG170_17525 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FG170_17530 ENOG4106V8H Nucleoid-associated protein FG170_17535 ENOG4105PAN UPF0352 protein FG170_17540 ENOG4105E68 Sulfatase FG170_17560 ENOG4105MSY salicylate hydroxylase FG170_17565 ENOG4108RXX maleylacetoacetate isomerase FG170_17590 ENOG4105DB1 molybdopterin oxidoreductase FG170_17595 ENOG4106WHD Tetrathionate reductase FG170_17605 ENOG4106AFQ Histidine kinase FG170_17610 ENOG4108ZXC Two component transcriptional regulator, luxr family FG170_17620 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FG170_17635 ENOG4105Y50 Virulence Protein FG170_17655 ENOG4105KKI DNA-binding transcriptional activator OsmE FG170_17670 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FG170_17680 ENOG4105M0C cytoplasmic protein FG170_17685 ENOG4106UW1 Major Facilitator superfamily FG170_17690 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FG170_17700 ENOG4105BZU Histidine kinase FG170_17705 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FG170_17710 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FG170_17715 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FG170_17720 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FG170_17725 ENOG4105XPH Ferredoxin FG170_17750 ENOG4105E0U tyrosine-specific transport protein FG170_17755 ENOG4108UII YfaZ family FG170_17760 ENOG4105CH6 catalase FG170_17775 ENOG4108IPT Naphthoate synthase FG170_17780 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FG170_17785 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FG170_17790 ENOG4105TNS Conserved Protein FG170_17795 ENOG4105CPQ Dehydrogenase FG170_17800 ENOG4105CHR reductase FG170_17805 ENOG4108UQ5 membrane protein YcdZ FG170_17815 ENOG4105HEI LysR family (Transcriptional regulator FG170_17820 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FG170_17825 ENOG4105C8S subunit m FG170_17830 ENOG4105D65 subunit l FG170_17835 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FG170_17840 ENOG4107UFS subunit j FG170_17875 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FG170_17880 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FG170_17890 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FG170_17920 ENOG4105XWI UPF0304 protein FG170_17935 ENOG4105C6K Malic enzyme FG170_17950 ENOG4108IUS Transketolase FG170_17955 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FG170_17985 ENOG4105PTV Nudix Hydrolase FG170_18000 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FG170_18010 ENOG4108JEH abc transporter atp-binding protein FG170_18015 ENOG4106YG3 ABC transporter FG170_18020 ENOG4105DSP amino acid AbC transporter FG170_18025 ENOG4105E89 ABC transporter FG170_18030 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FG170_18060 ENOG4105DQR SNARE associated Golgi FG170_18070 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FG170_18085 ENOG410631K Membrane FG170_18125 ENOG4105EQK -acetyltransferase FG170_18140 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FG170_18195 ENOG4105XCM membrane LIPOPROTEIN FG170_18200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FG170_18210 ENOG4105MH2 YfcL protein FG170_18215 ENOG4108BPE -transporting atpase FG170_18220 ENOG4105EJ9 Membrane FG170_18230 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FG170_18235 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FG170_18240 ENOG4108DG9 Smr protein MutS2 FG170_18245 ENOG4108BY2 phosphohistidine phosphatase FG170_18250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FG170_18255 ENOG4105CHU acetyl-coa acetyltransferase FG170_18260 ENOG4105KZW UPF0381 protein FG170_18265 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FG170_18270 ENOG410903C (LipO)protein FG170_18275 ENOG4105KWW Biogenesis protein FG170_18280 ENOG4105KWW Biogenesis protein FG170_18285 ENOG4107QX9 Thiol disulfide interChange protein FG170_18290 ENOG4105DA4 cytochrome c-type biogenesis protein FG170_18295 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FG170_18300 ENOG4105X3C heme exporter protein FG170_18305 ENOG41060IM Heme exporter protein FG170_18310 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FG170_18320 ENOG4105S64 Formate nitrite transporter FG170_18330 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FG170_18335 ENOG4105UEI Transcriptional Regulator AraC Family FG170_18355 ENOG4105WH1 Two component transcriptional regulator luxr family FG170_18365 ENOG4105W8I Transcriptional regulator FG170_18375 ENOG4108Q5Y Membrane FG170_18390 ENOG4105CVE Lytic murein transglycosylase FG170_18400 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin FG170_18410 ENOG4108VKM cytochrome b561 FG170_18415 ENOG4105CHM Aminotransferase FG170_18425 ENOG41072TH Protein of unknown function (DUF1479) FG170_18430 ENOG4108HRK Histidine kinase FG170_18435 ENOG4105DY9 regulatoR FG170_18440 ENOG41062C6 Protein of unknown function (DUF2502) FG170_18445 ENOG4105FCD Major Facilitator FG170_18470 ENOG4105C5Q Transcriptional regulator FG170_18475 ENOG4107RA9 decarboxylase FG170_18480 ENOG4105CPC Aldo Keto reductase FG170_18490 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FG170_18495 ENOG4105D9N nucleoside FG170_18510 ENOG4105TMB Formate nitrite transporter FG170_18515 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FG170_18550 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FG170_18555 ENOG4105DQ5 transport system permease protein FG170_18560 ENOG4105TVJ transport system, permease FG170_18565 ENOG4105E0A ABC, transporter FG170_18570 ENOG4105DEF Extracellular solute-binding protein, family 5 FG170_18575 ENOG4105C7K acetolactate synthase FG170_18590 ENOG4107FQ9 ethanolamine ammonia-lyase FG170_18595 ENOG4105CPD ethanolamine ammonia-lyase FG170_18610 ENOG4108M0I Transcriptional regulator FG170_18615 ENOG4105DHU Bile acid FG170_18620 ENOG4105VRT cytoplasmic protein FG170_18625 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FG170_18630 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FG170_18635 ENOG4105EXN Sulfate transport protein CysZ FG170_18640 ENOG4105C6T cysteine synthase FG170_18645 ENOG4105KZ7 phosphocarrier protein hpr FG170_18650 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FG170_18655 ENOG4105C5Y PTS System FG170_18660 ENOG4105E0F Histidine kinase FG170_18665 ENOG4105E3W Two component transcriptional regulator (Winged helix family FG170_18670 ENOG4105C6T cysteine synthase FG170_18680 ENOG4105ECW sulfate abc transporter FG170_18685 ENOG4108I5D sulfate abc transporter FG170_18690 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FG170_18695 ENOG4105EZR dyp-type peroxidase family protein FG170_18700 ENOG4105E7K (LipO)protein FG170_18705 ENOG4105QZU Inner membrane protein YfeZ FG170_18710 ENOG4105H4F exported protein FG170_18715 ENOG4108R6G acetyltransferase FG170_18720 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FG170_18725 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FG170_18730 ENOG4108UPT UPF0178 protein FG170_18755 ENOG41063SR receptor FG170_18760 ENOG4105CUG Oligopeptidase b FG170_18775 ENOG4108IQI permease FG170_18780 ENOG4107QK5 Homocysteine s-methyltransferase FG170_18795 ENOG4105C6K Malic enzyme FG170_18820 ENOG4105EQ1 Transcriptional regulator FG170_18825 ENOG4108M1A Chitin-binding protein FG170_18830 ENOG4105DKT Transcriptional regulator FG170_18840 ENOG4105CMT Dihydroxyacetone kinase FG170_18845 ENOG4108R85 Short chain dehydrogenase FG170_18850 ENOG4105IE8 Alpha-ketoglutarate permease FG170_18855 ENOG4105CPQ Dehydrogenase FG170_18860 ENOG4108YZG isomerase FG170_18865 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FG170_18875 ENOG4107VIJ nudix hydrolase FG170_18880 ENOG4105BZU Histidine kinase FG170_18885 ENOG4105WH1 Two component transcriptional regulator luxr family FG170_18895 ENOG4105BZS acriflavin resistance protein FG170_18910 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FG170_18915 ENOG4105VEV -acetyltransferase FG170_18925 ENOG4105KUZ arsenate reductase FG170_18930 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FG170_18940 ENOG4105XYK UPF0370 protein FG170_18945 ENOG4106KED esterase YpfH FG170_18955 ENOG4105CGZ zinc metallopeptidase FG170_18960 ENOG4105C8V SAICAR synthetase FG170_18965 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FG170_18970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FG170_18975 ENOG4105RH4 Glycine cleavage system transcriptional repressor FG170_18980 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FG170_18985 ENOG4105C02 permease FG170_19015 ENOG4105EW9 transcriptional regulator AsnC family FG170_19030 ENOG4105ERG peptidase m48, ste24p FG170_19050 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FG170_19065 ENOG4105Y3U Transglycosylase-associated protein FG170_19070 ENOG4105C2W permease FG170_19075 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FG170_19080 ENOG4105CXB phosphoribosylaminoimidazole synthetase FG170_19085 ENOG4108V3E phosphoribosylglycinamide formyltransferase FG170_19090 ENOG4108MK9 spermidine N(1)-acetyltransferase FG170_19130 ENOG4105D5K Hemolysin activator protein FG170_19150 ENOG4105C8U phosphate abc transporter FG170_19155 ENOG4105C8U phosphate abc transporter FG170_19165 ENOG4105C9X ppx gppa phosphatase FG170_19175 ENOG4105CJW magnesium transporter FG170_19180 ENOG4105BZU Histidine kinase FG170_19195 ENOG4105R8A Heat shock protein FG170_19210 ENOG4105CPC Aldo Keto reductase FG170_19215 ENOG4105ENT Efflux transporter rnd family, mfp subunit FG170_19220 ENOG4105BZS acriflavin resistance protein FG170_19225 ENOG4105BZS acriflavin resistance protein FG170_19230 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_19235 ENOG4105EB3 Histidine kinase FG170_19240 ENOG4105E3W Two component transcriptional regulator (Winged helix family FG170_19255 ENOG4105KWI UPF0339 protein FG170_19260 ENOG4105CFP Peptidase U32 FG170_19270 ENOG4107TE5 Lipid kinase FG170_19280 ENOG4105CPQ Dehydrogenase FG170_19285 ENOG4108I5G Major Facilitator superfamily FG170_19300 ENOG4107XBN GntR Family Transcriptional Regulator FG170_19305 ENOG4105EIE fructose-bisphosphate aldolase FG170_19315 ENOG410787A Pts system, glucitol sorbitol-specific FG170_19320 ENOG4105DZY Pts system, glucitol sorbitol-specific FG170_19325 ENOG4105VI0 Pts system, glucitol sorbitol-specific FG170_19330 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FG170_19335 ENOG4105J92 DNA-binding transcriptional activator GutM FG170_19340 ENOG410804X Transcriptional regulator FG170_19350 ENOG4108ZGU inhibitor of vertebrate lysozyme FG170_19355 ENOG4105DWF phosphomethylpyrimidine kinase FG170_19360 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FG170_19375 ENOG4105J12 Multidrug resistance protein mdtN FG170_19380 ENOG4108MI0 Resistance protein FG170_19400 ENOG4105FE9 pseudouridine synthase FG170_19420 ENOG4105BZU Histidine kinase FG170_19430 ENOG4105KVH Transcriptional regulator FG170_19450 ENOG4108RS6 transposase FG170_19455 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FG170_19460 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FG170_19480 ENOG4105DPW Major facilitator superfamily MFS_1 FG170_19485 ENOG4105ETE Transcriptional regulator (LacI family FG170_19490 ENOG4105D4Y metalloprotease FG170_19500 ENOG4105VPD cellular component movement FG170_19510 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FG170_19515 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FG170_19520 ENOG4105N21 Membrane FG170_19525 ENOG4105CUT histidyl-tRNA synthetase FG170_19530 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FG170_19535 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FG170_19545 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FG170_19550 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FG170_19555 ENOG4105YYA enhanced serine sensitivity protein SseB FG170_19565 ENOG4105WVQ Fe-S assembly protein IscX FG170_19570 ENOG4108ZIT Ferredoxin, 2FE-2S FG170_19575 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FG170_19580 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FG170_19585 ENOG4108Z4V iron-sulfur cluster assembly FG170_19590 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FG170_19595 ENOG4105C3J Cysteine desulfurase FG170_19600 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FG170_19610 ENOG4105ECY inositol monophosphatase FG170_19615 ENOG4105D7X high-affinity nickel-transporter FG170_19620 ENOG41065CD Exported protein FG170_19625 ENOG4108MN2 Stationary phase inducible protein CsiE FG170_19630 ENOG4105D8G Major Facilitator superfamily FG170_19635 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FG170_19640 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FG170_19655 ENOG4105C26 Dehydrogenase FG170_19660 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FG170_19665 ENOG4105D81 ABC transporter, permease FG170_19670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FG170_19675 ENOG4107TYH extracellular solute-binding protein family 1 FG170_19685 ENOG4107RSM transcriptional regulator FG170_19690 ENOG4108YZA Nitrogen regulatory protein pii FG170_19695 ENOG4105C4K Nad synthetase FG170_19700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FG170_19705 ENOG4108SKK alpha helix protein FG170_19710 ENOG4107WP9 Histidine kinase FG170_19720 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FG170_19725 ENOG4108Z6B deaminase FG170_19735 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FG170_19745 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FG170_19750 ENOG4106G6Q Transcriptional regulator FG170_19755 ENOG4108I6E Sulfatase FG170_19760 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FG170_19765 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FG170_19770 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FG170_19775 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FG170_19780 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FG170_19785 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FG170_19790 ENOG4105C3F Signal peptidase i FG170_19795 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FG170_19805 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FG170_19810 ENOG4105VQK sigma E regulatory protein, MucB RseB FG170_19825 ENOG4108IYU L-aspartate oxidase FG170_19830 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FG170_19835 ENOG4105C1J atp-dependent rna helicase FG170_19855 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FG170_19865 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FG170_19870 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FG170_19875 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FG170_19880 ENOG4105VDB UPF0125 protein FG170_19885 ENOG4108Z1B Cyclase dehydrase FG170_19890 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FG170_19935 ENOG4105S5I Membrane FG170_19950 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FG170_19975 ENOG410830R acetyltransferase FG170_19980 ENOG4105VR1 Pfam:DUF1271 FG170_19985 ENOG4108SB3 DoxX Family FG170_19990 ENOG4108DG9 Smr protein MutS2 FG170_20000 ENOG4108SAJ Protein of unknown function (DUF1198) FG170_20005 ENOG4108WMJ Protein of unknown function (DUF2002) FG170_20010 ENOG4105F9N Major Facilitator Superfamily FG170_20015 ENOG4105JQN Transcriptional regulator FG170_20020 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_20035 ENOG4105TNS Conserved Protein FG170_20045 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FG170_20050 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FG170_20055 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FG170_20065 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FG170_20085 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FG170_20090 ENOG4105Q2H domain protein FG170_20100 ENOG4105D2K citrate carrier protein FG170_20105 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FG170_20110 ENOG4106YYS transcriptional regulatory protein FG170_20115 ENOG4108IJ7 Glycine betaine FG170_20120 ENOG4108HQS Glycine betaine FG170_20125 ENOG4105GIJ Glycine betaine FG170_20130 ENOG4106NZI LysR family Transcriptional regulator FG170_20140 ENOG4108UMN azlc family FG170_20145 ENOG4105ZED uncharacterized protein ygaH FG170_20150 ENOG4105NTK Transcriptional repressor Mpra FG170_20160 ENOG4105CW7 secretion protein, HlyD family FG170_20165 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_20170 ENOG4105EIB trna rrna methyltransferase FG170_20175 ENOG4105K63 Thioredoxin FG170_20180 ENOG4106IUH DTW domain containing protein FG170_20185 ENOG4105CD5 CoA-binding domain protein FG170_20190 ENOG4105JIM Phosphatidylserine synthase FG170_20195 ENOG4105CSH Transporter FG170_20225 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FG170_20235 ENOG4108UMI ABC transporter, permease FG170_20240 ENOG4105D01 (LipO)protein FG170_20245 ENOG4108R8X outer membrane lipoprotein FG170_20250 ENOG4108R96 Methyltransferase, YaeB family FG170_20260 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FG170_20265 ENOG4108YZN class I peptide chain release factor FG170_20270 ENOG4108VWS Yaeq family FG170_20280 ENOG4105M1T rho-binding antiterminator FG170_20285 ENOG4105N7H Cytochrome FG170_20290 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FG170_20295 ENOG4105DUX Transporter FG170_20300 ENOG4105CXN decarboxylase FG170_20305 ENOG4105D5Q Arginine ornithine antiporter FG170_20310 ENOG4108M3R transcriptional activator CadC FG170_20315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FG170_20335 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FG170_20340 ENOG4105C0B DNA polymerase III (alpha subunit) FG170_20345 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FG170_20350 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FG170_20355 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FG170_20360 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FG170_20365 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FG170_20370 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FG170_20375 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FG170_20380 ENOG4105DZP Membrane-associated zinc metalloprotease FG170_20385 ENOG4105KNE Phosphatidate cytidylyltransferase FG170_20390 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FG170_20395 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FG170_20400 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FG170_20405 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FG170_20410 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FG170_20415 ENOG4105CE9 30S ribosomal protein S2 FG170_20420 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FG170_20425 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FG170_20435 ENOG4108T8E UPF0325 protein FG170_20440 ENOG4105QDK Flavodoxin FG170_20445 ENOG4105DR9 pseudouridine synthase FG170_20450 ENOG4108JQB penicillin-binding protein 1C FG170_20455 ENOG4105DN3 alpha-2-macroglobulin domain protein FG170_20460 ENOG4105WP7 tRNA pseudouridine synthase C FG170_20465 ENOG4107RGD Major Facilitator superfamily FG170_20480 ENOG4105EWT decarboxylase family FG170_20485 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FG170_20490 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FG170_20495 ENOG4105M08 Membrane FG170_20500 ENOG4105ETT transcriptional Regulator, LysR family FG170_20505 ENOG4105M5B (LipO)protein FG170_20515 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FG170_20525 ENOG4105CA3 membrane-bound lytic murein transglycosylase FG170_20545 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FG170_20550 ENOG4107QZM n-acetylglutamate synthase FG170_20555 ENOG4107QYX exodeoxyribonuclease v alpha FG170_20560 ENOG4107QKA exodeoxyribonuclease V beta FG170_20565 ENOG4107QXK peptidase FG170_20570 ENOG4105DSY exodeoxyribonuclease V, gamma FG170_20590 ENOG4105IPU prepilin peptidase dependent protein A FG170_20595 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FG170_20600 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FG170_20605 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FG170_20610 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FG170_20615 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FG170_20620 ENOG4105EE5 Membrane protein terC FG170_20625 ENOG4105SUV lipoprotein YgdR FG170_20630 ENOG4105CPC Aldo Keto reductase FG170_20635 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FG170_20640 ENOG4105CEY Amp-dependent synthetase and ligase FG170_20650 ENOG4105GQR Chaperone FG170_20655 ENOG4108D1K outer membrane usher protein FG170_20670 ENOG41060NJ transcriptional regulator FG170_20685 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FG170_20690 ENOG4105RQF LysR family Transcriptional regulator FG170_20695 ENOG4105EJC lysr family transcriptional regulator FG170_20715 ENOG4105CQ0 ABC transporter FG170_20725 ENOG4105F3R pts system mannose fructose sorbose family iid FG170_20730 ENOG4105ETZ PTS System FG170_20735 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB FG170_20740 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of FG170_20750 ENOG4105DJ2 Major Facilitator Superfamily FG170_20765 ENOG4105JQN Transcriptional regulator FG170_20770 ENOG4105DAA L-lactate FG170_20785 ENOG4107RGD Major Facilitator superfamily FG170_20800 ENOG4105C94 Transporter FG170_20805 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FG170_20810 ENOG4108JJ7 ABC transporter FG170_20815 ENOG4105F4I Transcriptional regulator FG170_20820 ENOG4108K5P (LipO)protein FG170_20825 ENOG4105CHJ isochorismatase hydrolase FG170_20830 ENOG4105CR8 Transcriptional regulator FG170_20835 ENOG4108YK4 Acid-resistance membrane protein FG170_20845 ENOG4105UYK outer membrane protein a FG170_20860 ENOG4105C9B Cysteine desulfurase FG170_20865 ENOG4105K2J Transcriptional regulator FG170_20885 ENOG4108R66 Conserved Protein FG170_20890 ENOG4105C5I Dehydrogenase FG170_20895 ENOG4105DJB Major Facilitator Superfamily FG170_20965 ENOG4105E4C Lytic transglycosylase catalytic FG170_21020 ENOG4105XB7 anti-repressor protein FG170_21040 ENOG4105DFP Integrase FG170_21050 ENOG4105CRK lysyL-tRNA synthetase FG170_21075 ENOG4105T95 Thiol disulfide interChange protein FG170_21080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FG170_21085 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FG170_21090 ENOG4105CT7 inner membrane cred family protein FG170_21095 ENOG4105EB3 Histidine kinase FG170_21100 ENOG4105E3W Two component transcriptional regulator (Winged helix family FG170_21110 ENOG4105Y75 tpr repeat protein FG170_21115 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FG170_21125 ENOG4108UT2 hemolysin iii FG170_21135 ENOG4108RVA ribokinase FG170_21140 ENOG4107TFG D-allose kinase FG170_21155 ENOG4105CNN ABC, transporter FG170_21160 ENOG4105C2J ABC transporter FG170_21170 ENOG4105E98 transcriptional regulator DeoR family FG170_21210 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FG170_21240 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FG170_21245 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FG170_21250 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FG170_21255 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FG170_21260 ENOG4105D0A hydroxylase FG170_21265 ENOG4107RAQ aminopeptidase FG170_21270 ENOG4105E07 UPF0149 protein FG170_21285 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FG170_21290 ENOG4108JQ1 Dehydrogenase FG170_21295 ENOG4105E66 phosphoriboisomerase A FG170_21300 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FG170_21305 ENOG4105MPN Membrane FG170_21310 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FG170_21315 ENOG4105J4Q Transcriptional regulator FG170_21320 ENOG4105C2J ABC transporter FG170_21325 ENOG4105CNN ABC, transporter FG170_21345 ENOG4108R66 Conserved Protein FG170_21355 ENOG4105CMG Carbohydrate kinase FG170_21360 ENOG4105H6Q decarboxylase FG170_21365 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FG170_21370 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FG170_21375 ENOG4105D3G Pseudouridine synthase FG170_21380 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FG170_21400 ENOG4105D64 Mechanosensitive ion channel FG170_21410 ENOG4105D2N Aldolase FG170_21420 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FG170_21425 ENOG4105EJC lysr family transcriptional regulator FG170_21430 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FG170_21435 ENOG4105C94 Transporter FG170_21440 ENOG4105DVW rieske (2Fe-2S) FG170_21445 ENOG4105C26 Dehydrogenase FG170_21450 ENOG4105E3J oxidoreductase FG170_21455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FG170_21460 ENOG4107Z33 ABC transporter, permease FG170_21475 ENOG4108Z7R Chaperone CsaA FG170_21485 ENOG4105CWM branched-chain amino acid transport system II carrier protein FG170_21490 ENOG4105CV1 Transketolase (EC 2.2.1.1) FG170_21495 ENOG4108K0D peptidase, M48 FG170_21510 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) FG170_21515 ENOG4105CHR reductase FG170_21545 ENOG4108FUF Transcriptional regulator, IclR family FG170_21550 ENOG4105CHR reductase FG170_21570 ENOG4105DJB Major Facilitator Superfamily FG170_21575 ENOG4105WI6 cell killing protein encoded within cryptic prophage FG170_21580 ENOG4105CYW agmatinase FG170_21590 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FG170_21600 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FG170_21605 ENOG4105WI6 cell killing protein encoded within cryptic prophage FG170_21615 ENOG4105J76 Periplasmic binding protein FG170_21620 ENOG4105E0A ABC, transporter FG170_21625 ENOG4105E0K tonB-dependent siderophore receptor FG170_21630 ENOG4105BZ4 penicillin-binding protein FG170_21635 ENOG4105CQ7 ATP-dependent helicase FG170_21640 ENOG4107XID 2'-5' rna ligase FG170_21645 ENOG4105PW4 Sugar fermentation stimulation protein homolog FG170_21650 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FG170_21655 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FG170_21660 ENOG4105DJ0 Poly(A) Polymerase FG170_21665 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FG170_21670 ENOG4105DHQ Histidine kinase FG170_21675 ENOG4105XJC Two component transcriptional regulator (Winged helix family FG170_21680 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FG170_21685 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FG170_21690 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FG170_21695 ENOG4107BJW polysaccharide deacetylase FG170_21700 ENOG4105E3A (ABC) transporter FG170_21705 ENOG4105DA5 (ABC) transporter FG170_21710 ENOG41077A9 carbonic anhydrase FG170_21715 ENOG4108UGV hypoxanthine phosphoribosyltransferase FG170_21720 ENOG4105E3B Multicopper oxidase FG170_21725 ENOG4108ZRK uncharacterized protein yacC FG170_21730 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FG170_21735 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FG170_21740 ENOG4108ZIG UPF0231 protein FG170_21745 ENOG4107QIJ Aconitate hydratase 2 FG170_21750 ENOG4107QN2 dihydrolipoyl dehydrogenase FG170_21760 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FG170_21765 ENOG41073TP transcriptional regulator FG170_21770 ENOG4105C85 amino acid FG170_21775 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FG170_21785 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FG170_21795 ENOG4105XRQ Xanthine dehydrogenase accessory factor FG170_21800 ENOG4105UEI Transcriptional Regulator AraC Family FG170_21805 ENOG4107GFK fumarate FG170_21810 ENOG4105GPY SprT protein FG170_21815 ENOG4105RWS endonuclease I FG170_21820 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FG170_21825 ENOG4105D7Z glutathione synthase FG170_21830 ENOG4108UJU UPF0301 protein FG170_21835 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FG170_21845 ENOG4105DFA alanine racemase domain protein FG170_21850 ENOG4105II7 pyrroline-5-carboxylate reductase FG170_21855 ENOG4108VIA integral membrane protein FG170_21860 ENOG4105VZ9 UPF0235 protein FG170_21870 ENOG4105CSA Coproporphyrinogen iii oxidase FG170_21885 ENOG4105K33 Periplasmic Protein FG170_21890 ENOG4105CSV Glutaminase FG170_21895 ENOG41090ED Protein with unknown function (DUF469) FG170_21900 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FG170_21905 ENOG4105CEN a g-specific adenine glycosylase FG170_21910 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FG170_21915 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FG170_21920 ENOG4105CXN decarboxylase FG170_21950 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FG170_22095 ENOG4105R1U AraC Family Transcriptional Regulator FG170_22110 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FG170_22215 ENOG4108MIB FG170_22220 ENOG4108UUM single-stranded DNA-binding protein FG170_22270 ENOG4105CDU Replicative dna helicase FG170_22300 ENOG4105ZS6 Protein of unknown function (DUF987) FG170_22305 ENOG4108WC9 type VI secretion system effector, hcp1 family FG170_22310 ENOG4108WC9 type VI secretion system effector, hcp1 family FG170_22320 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FG170_22330 ENOG4105NIV Esterase FG170_22335 ENOG4105VEV -acetyltransferase FG170_22360 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FG170_22365 ENOG4105HSS phospholipase C FG170_22375 ENOG4105GAV receptor FG170_22380 ENOG4106KR7 LysR family Transcriptional regulator FG170_22385 ENOG4105CH2 amidohydrolase FG170_22390 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FG170_22400 ENOG4105D7K pfkb domain protein FG170_22420 ENOG4105WBN Transcriptional regulator (LacI family FG170_22425 ENOG4108ZZF transport protein (ExbD) FG170_22430 ENOG4105CWK Biopolymer transport protein, ExbB FG170_22435 ENOG4105C28 cystathionine FG170_22440 ENOG4108K81 inner membrane protein YghB FG170_22445 ENOG4105CC0 LysR family Transcriptional regulator FG170_22455 ENOG4105CF7 AraC family transcriptional regulator FG170_22460 ENOG4108I6A alcohol dehydrogenase FG170_22465 ENOG4105CV8 reductase FG170_22470 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FG170_22480 ENOG4105C6F GntR Family Transcriptional Regulator FG170_22490 ENOG4108TFM Kinase, PfkB family FG170_22495 ENOG4105EAA nucleoside FG170_22500 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FG170_22505 ENOG4105CN8 Transcriptional regulator FG170_22510 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FG170_22515 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FG170_22525 ENOG4105NF4 modulator of drug activity FG170_22530 ENOG4105VRH Antibiotic biosynthesis monooxygenase FG170_22535 ENOG4105HEI LysR family (Transcriptional regulator FG170_22540 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FG170_22545 ENOG4105IPS esterase FG170_22550 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FG170_22555 ENOG4108SX3 cytoplasmic protein FG170_22560 ENOG41087AY ADP-Ribose pyrophosphatase FG170_22565 ENOG4105DFG type I secretion outer membrane protein FG170_22575 ENOG4105VDH Dihydroxyacetone kinase FG170_22580 ENOG4108UTZ Dihydroxyacetone kinase FG170_22585 ENOG4105CMT Dihydroxyacetone kinase FG170_22595 ENOG4105F1G UPF0441 protein FG170_22600 ENOG4106032 Glutathionylspermidine synthase FG170_22605 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FG170_22615 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FG170_22620 ENOG4105W0Z cytoplasmic protein FG170_22625 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FG170_22630 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FG170_22635 ENOG4105I7R Adenylate cyclase FG170_22640 ENOG4106MWK domain protein FG170_22650 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FG170_22655 ENOG4107ZVW dihydroneopterin aldolase FG170_22660 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FG170_22665 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FG170_22670 ENOG4105VCC 30S ribosomal protein S21 FG170_22675 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FG170_22680 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FG170_22735 ENOG4108SHQ Glutathione S-transferase FG170_22745 ENOG4105C26 Dehydrogenase FG170_22750 ENOG4108JPW Aminotransferase FG170_22760 ENOG4105C5H ABC transporter FG170_22765 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FG170_22770 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FG170_22775 ENOG4108VKG metal-dependent hydrolase FG170_22780 ENOG4105EE0 oxidoreductase FG170_22785 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FG170_22790 ENOG4105DU1 integral membrane protein, terc FG170_22795 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FG170_22800 ENOG4105CTX dehydratase FG170_22805 ENOG4105D2H Uronic isomerase FG170_22810 ENOG4105DPW Major facilitator superfamily MFS_1 FG170_22825 ENOG4106W5V Membrane FG170_22830 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FG170_22840 ENOG4105NE1 Conserved Protein FG170_22845 ENOG41090KG Inner membrane protein YqjE FG170_22850 ENOG4105YJD FG170_22855 ENOG4108VBZ doxx family FG170_22860 ENOG4105CHF Glutathione S-transferase FG170_22865 ENOG4105CWB LysR family transcriptional Regulator FG170_22870 ENOG4108CNN domain protein FG170_22880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FG170_22885 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FG170_22890 ENOG41082RQ UPF0102 protein FG170_22895 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FG170_22900 ENOG4105W4M Transport-associated protein FG170_22910 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FG170_22915 ENOG4105BZU Histidine kinase FG170_22920 ENOG4105N5T Radical SAM Protein FG170_22925 ENOG4105CBC glutamate synthase FG170_22930 ENOG4105BZ8 glutamate synthase FG170_22940 ENOG4105KB2 stringent starvation protein b FG170_22945 ENOG4107MKT Stringent starvation protein a FG170_22950 ENOG4108UJD 30S ribosomal protein S9 FG170_22955 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FG170_22960 ENOG4105D6Z AFG1 family ATPase FG170_22965 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FG170_22970 ENOG4105C0H protease FG170_22975 ENOG4105C0H protease FG170_22980 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FG170_22985 ENOG4105VFK BolA family FG170_22990 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FG170_22995 ENOG4105E3I toluene tolerance FG170_23000 ENOG4107PE3 Mammalian cell entry related domain protein FG170_23005 ENOG4105CY3 ABC transporter, permease FG170_23010 ENOG4105DHJ ABC, transporter FG170_23015 ENOG4105FEU K -dependent Na -Ca exchanger FG170_23020 ENOG4105C2X Arabinose 5-phosphate isomerase FG170_23025 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FG170_23030 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FG170_23035 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FG170_23040 ENOG4108IUZ ABC transporter FG170_23045 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FG170_23050 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FG170_23055 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FG170_23060 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FG170_23065 ENOG41080Z8 PHOSPHOCARRIER protein FG170_23070 ENOG4105EMD TRANSCRIPTIONal FG170_23090 ENOG41069H0 dihydroorotase EC 3.5.2.3 FG170_23120 ENOG4105NXH GreA GreB family elongation factor FG170_23130 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FG170_23140 ENOG4105R1U AraC Family Transcriptional Regulator FG170_23145 ENOG4108XVM Cytochrome b(562) FG170_23150 ENOG4105CMS peptidase U62, modulator of DNA gyrase FG170_23155 ENOG4105N42 UPF0307 protein FG170_23160 ENOG4105UNR (Barnase) inhibitor FG170_23170 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) FG170_23175 ENOG4105Y49 secretion protein, HlyD family FG170_23185 ENOG4105CR8 Transcriptional regulator FG170_23200 ENOG4105DU0 nucleoside hydrolase FG170_23210 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) FG170_23215 ENOG4105D1U peptidase U62 modulator of DNA gyrase FG170_23230 ENOG4105C03 ribonuclease FG170_23240 ENOG4105VQ7 Rod shape-determining protein MreD FG170_23245 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FG170_23250 ENOG4105DFF Rod shape-determining protein mreb FG170_23255 ENOG41062P1 Diguanylate cyclase phosphodiesterase FG170_23260 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FG170_23265 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FG170_23270 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FG170_23275 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FG170_23280 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FG170_23285 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FG170_23290 ENOG4105RG0 Membrane FG170_23295 ENOG4108IA2 Sodium pantothenate symporter FG170_23300 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FG170_23310 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FG170_23325 ENOG4105D1S lipid A biosynthesis FG170_23330 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FG170_23355 ENOG4105CMU LysR family (Transcriptional regulator FG170_23360 ENOG4105EEQ Na H antiporter FG170_23365 ENOG4105C7N Xanthine uracil vitamin C permease FG170_23375 ENOG4108RXX maleylacetoacetate isomerase FG170_23390 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FG170_23415 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FG170_23420 ENOG4105DQ4 alcohol dehydrogenase FG170_23425 ENOG4108UW5 maltose o-acetyltransferase FG170_23430 ENOG4105MSB protein, conserved in bacteria FG170_23435 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FG170_23440 ENOG4105CGF Aromatic amino acid aminotransferase FG170_23445 ENOG4108XM1 transcriptional regulator AsnC family FG170_23450 ENOG4105F87 Dehydratase FG170_23455 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FG170_23460 ENOG4105CDU Replicative dna helicase FG170_23465 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FG170_23470 ENOG4105P4Z Phage shock protein G FG170_23475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FG170_23495 ENOG4105MYN Zinc uptake regulation protein FG170_23500 ENOG4105VDW Csbd family FG170_23505 ENOG4107R73 Mate efflux family protein FG170_23510 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FG170_23515 ENOG41080IJ Diacylglycerol kinase FG170_23520 ENOG4105E55 glycerol-3-phosphate acyltransferase FG170_23525 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FG170_23530 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FG170_23540 ENOG4105ETE Transcriptional regulator (LacI family FG170_23550 ENOG4107W52 maltose operon periplasmic protein FG170_23555 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FG170_23570 ENOG4107FKK extracellular solute-binding protein family 1 FG170_23575 ENOG4105D56 permease protein FG170_23580 ENOG4105EG2 ABC transporter, permease FG170_23585 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FG170_23590 ENOG4108MRJ FG170_23595 ENOG4107QP8 phosphohexose isomerase FG170_23605 ENOG4105CFH Aspartokinase FG170_23610 ENOG4105C09 Bile acid FG170_23625 ENOG4105EAM Na Pi-cotransporter FG170_23630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FG170_23645 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FG170_23655 ENOG4106S9K Transcriptional regulator FG170_23660 ENOG4105C3R Methionine synthase FG170_23665 ENOG41069M3 Transcriptional regulator FG170_23670 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FG170_23675 ENOG4105C6Z Gluconate FG170_23680 ENOG4105C01 Dihydroxy-acid dehydratase FG170_23685 ENOG4108UHU Aldolase FG170_23690 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FG170_23695 ENOG4108I9X Isocitrate lyase FG170_23700 ENOG4107QP3 malate synthase g FG170_23705 ENOG4105CVG Homoserine O-transsuccinylase FG170_23740 ENOG4108Z0R Transferase FG170_23745 ENOG4105E2X shikimate dehydrogenase FG170_23750 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FG170_23755 ENOG4108WI1 Dna topoisomerase FG170_23760 ENOG4108RPN Protein smg homolog FG170_23765 ENOG4105C79 DNA protecting protein DprA FG170_23770 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FG170_23775 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FG170_23780 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FG170_23785 ENOG4105C1A potassium transporter peripheral membrane FG170_23790 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FG170_23795 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FG170_23800 ENOG4105W1Y Transcriptional regulator FG170_23805 ENOG4105VTS DnaJ-like, subfamily C FG170_23810 ENOG4108ZT0 50S ribosomal protein l17 FG170_23815 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FG170_23820 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FG170_23825 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FG170_23830 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FG170_23835 ENOG41067V7 50S ribosomal protein L36 FG170_23840 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FG170_23850 ENOG4105VPB 50S ribosomal protein L30 FG170_23855 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FG170_23860 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FG170_23865 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FG170_23870 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FG170_23885 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FG170_23890 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FG170_23895 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FG170_23905 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FG170_23910 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FG170_23920 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FG170_23930 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FG170_23935 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FG170_23940 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FG170_23965 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FG170_23970 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FG170_23980 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FG170_23985 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FG170_23990 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FG170_23995 ENOG4105WWK YheO domain protein FG170_24000 ENOG4108V1T peptidylprolyl cis-trans isomerase FG170_24010 ENOG4105C87 Aminotransferase class I and II FG170_24015 ENOG4105DFD Na H antiporter FG170_24020 ENOG41060NJ transcriptional regulator FG170_24025 ENOG4108YZY peptidylprolyl cis-trans isomerase FG170_24030 ENOG4105VKU nucleicacid-binding protein FG170_24040 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FG170_24045 ENOG4105C5H ABC transporter FG170_24050 ENOG4105E2B Taurine dioxygenase FG170_24055 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FG170_24065 ENOG4106FTQ Taurine ABC transporter, periplasmic FG170_24070 ENOG4105JAB phenazine biosynthesis protein, phzf family FG170_24080 ENOG4105DNZ Alpha Beta Hydrolase FG170_24085 ENOG4105YP7 UPF0270 protein FG170_24090 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FG170_24095 ENOG4108UKZ OsmC family FG170_24100 ENOG4107RYR Transcriptional regulator, Crp Fnr family FG170_24105 ENOG410613R integral membrane protein, YccS YhfK family FG170_24110 ENOG4105C8Y Acetylornithine aminotransferase FG170_24120 ENOG4105D7A ATP-binding protein FG170_24125 ENOG4108NEV two component transcriptional regulator, LytTR family FG170_24130 ENOG4108HRK Histidine kinase FG170_24135 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FG170_24145 ENOG4105VCP PTS System FG170_24150 ENOG4105F8D glycoside hydrolase family 4 FG170_24155 ENOG41060NJ transcriptional regulator FG170_24160 ENOG4106DTQ Protein TsgA homolog FG170_24165 ENOG4105DZC cytosine deaminase FG170_24175 ENOG4107QZF nitrite reductase NADPH large subunit FG170_24180 ENOG4105WZK nitrite reductase NADPH small subunit FG170_24185 ENOG4107V9H nitrite transporter FG170_24190 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FG170_24195 ENOG4105C31 Tryptophanyl-tRNA synthetase FG170_24200 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FG170_24220 ENOG4105D49 3-dehydroquinate synthase FG170_24225 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FG170_24230 ENOG4105E4G Type IV pilus FG170_24255 ENOG4108JQC penicillin-binding protein 1A FG170_24260 ENOG4107RK2 ADP-ribose diphosphatase NudE FG170_24265 ENOG4105DQY intracellular growth attenuator FG170_24270 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FG170_24275 ENOG4105VEJ Heat shock protein FG170_24280 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FG170_24300 ENOG4105E0F Histidine kinase FG170_24305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FG170_24310 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) FG170_24315 ENOG4105DVC DnaJ domain protein FG170_24320 ENOG4108RRZ Transcription elongation factor GreB FG170_24325 ENOG4105BZM domain protein FG170_24330 ENOG4105XFK Ferrous iron transport protein A FG170_24340 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) FG170_24355 ENOG4105MJ2 Competence protein FG170_24360 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FG170_24365 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FG170_24370 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FG170_24375 ENOG41061ZR Transcriptional regulator FG170_24380 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FG170_24385 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FG170_24390 ENOG4105E98 transcriptional regulator DeoR family FG170_24395 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FG170_24400 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FG170_24410 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FG170_24415 ENOG4108ESZ Glycogen debranching enzyme FG170_24420 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FG170_24430 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FG170_24435 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FG170_24440 ENOG4105C6Z Gluconate FG170_24445 ENOG4105DIQ Transcriptional regulator FG170_24450 ENOG4105C2I pirin domain protein FG170_24455 ENOG4105WCN acetyltransferase FG170_24460 ENOG4105KXX peptidase s58 dmpa FG170_24465 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FG170_24470 ENOG4105F0H myo-inositol catabolism protein FG170_24475 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FG170_24480 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FG170_24485 ENOG4105D7K pfkb domain protein FG170_24495 ENOG4105DH8 myo-inositol catabolism FG170_24500 ENOG4105C26 Dehydrogenase FG170_24505 ENOG4107QNK )-transporter FG170_24515 ENOG4105C4B ABC transporter, permease FG170_24520 ENOG41083J0 (ABC) transporter FG170_24540 ENOG4106PG1 outer membrane usher protein FG170_24545 ENOG4106P2F Pfam:Pili_assembly_C FG170_24565 ENOG4108N8T regulatoR FG170_24575 ENOG4105T38 integral membrane protein FG170_24595 ENOG4107RSM transcriptional regulator FG170_24605 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FG170_24615 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FG170_24625 ENOG4105CBX hi0933 family FG170_24630 ENOG4105CJ3 phosphate transporter FG170_24645 ENOG4105CBN LysR family transcriptional regulator FG170_24650 ENOG4108M6U Universal stress protein A FG170_24665 ENOG4105C2J ABC transporter FG170_24670 ENOG4105CNN ABC, transporter FG170_24675 ENOG4105CNN ABC, transporter FG170_24690 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FG170_24715 ENOG4105DC8 reductase FG170_24725 ENOG4105JAB phenazine biosynthesis protein, phzf family FG170_24735 ENOG4107SQD Transcriptional regulator, GntR family FG170_24745 ENOG4105BZU Histidine kinase FG170_24770 ENOG4105EQN UPF0261 protein FG170_24775 ENOG4108SPG Periplasmic Protein FG170_24780 ENOG4105BZU Histidine kinase FG170_24785 ENOG4105E39 Enoyl-CoA hydratase FG170_24795 ENOG4105CSH Transporter FG170_24800 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) FG170_24805 ENOG41066T0 asmA family FG170_24810 ENOG4105CMB EAL domain-containing protein FG170_24815 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FG170_24825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FG170_24830 ENOG4105EMY transcriptional regulator FG170_24850 ENOG4105C7B Threonine dehydratase FG170_24855 ENOG4105C01 Dihydroxy-acid dehydratase FG170_24860 ENOG4105CM2 brancheD-chain amino acid aminotransferase FG170_24865 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FG170_24880 ENOG4107RGD Major Facilitator superfamily FG170_24885 ENOG4105C0P Mg chelatase subunit ChlI FG170_24890 ENOG4108WFC UPF0438 protein yifE FG170_24895 ENOG4105CVI Transcriptional regulator FG170_24935 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FG170_24940 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FG170_24945 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FG170_24950 ENOG4108Y73 Membrane FG170_24960 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FG170_24965 ENOG4105C5Q Transcriptional regulator FG170_24970 ENOG4105EHV domain protein FG170_24975 ENOG4107QN2 dihydrolipoyl dehydrogenase FG170_24990 ENOG4105CH7 arginosuccinase FG170_24995 ENOG4105CDH Citrulline--aspartate ligase FG170_25000 ENOG4105CAS nag kinase FG170_25005 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FG170_25015 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FG170_25020 ENOG4105SYT Methylenetetrahydrofolate reductase FG170_25025 ENOG4105CFH Aspartokinase FG170_25030 ENOG4105C28 cystathionine FG170_25035 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FG170_25040 ENOG4105VFB Binds the 23S rRNA (By similarity) FG170_25045 ENOG4105C25 Primosomal protein n' FG170_25050 ENOG4105ETE Transcriptional regulator (LacI family FG170_25055 ENOG41063M6 Cell Division Protein FG170_25060 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FG170_25065 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FG170_25070 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FG170_25075 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FG170_25080 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FG170_25085 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FG170_25095 ENOG4105CBT Fructose-1,6-bisphosphatase FG170_25100 ENOG4105E5M Multidrug resistance protein D FG170_25110 ENOG4105DP0 ferredoxin-NADP reductase FG170_25115 ENOG4108VTS Membrane FG170_25125 ENOG4105CP7 Triose-phosphate isomerase FG170_25130 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FG170_25145 ENOG4105FMW periplasmic FG170_25150 ENOG4105E3W Two component transcriptional regulator (Winged helix family FG170_25155 ENOG4105E0F Histidine kinase FG170_25160 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FG170_25170 ENOG4108KKZ (LipO)protein FG170_25175 ENOG4105D7W serine acetyltransferase FG170_25190 ENOG4105VW4 glutaredoxin 3 FG170_25195 ENOG4107YZP Rhodanese domain protein FG170_25200 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FG170_25205 ENOG41063SB peptidase FG170_25215 ENOG4105CPQ Dehydrogenase FG170_25220 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FG170_25225 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FG170_25230 ENOG4105XA0 heptosyltransferase ii FG170_25235 ENOG4105D16 lipopolysaccharide heptosyltransferase i FG170_25240 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FG170_25245 ENOG41068PG O-Antigen polymerase FG170_25265 ENOG4105DKP glycosyl transferase, family 9 FG170_25270 ENOG4107RJ7 Glycosyl transferase (Group 1 FG170_25275 ENOG4105CPK Glycosyl transferase (Group 1 FG170_25285 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FG170_25305 ENOG4105W0E 50S ribosomal protein L33 FG170_25310 ENOG4105KDC 50s ribosomal protein l28 FG170_25315 ENOG4105W5Q DNA repair protein (RadC FG170_25325 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FG170_25330 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FG170_25335 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FG170_25340 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FG170_25345 ENOG4105DSJ YicC domain protein FG170_25355 ENOG4105D9N nucleoside FG170_25365 ENOG4105EN6 Membrane FG170_25370 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FG170_25375 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FG170_25380 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FG170_25385 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FG170_25390 ENOG4105CB5 ATP-dependent DNA helicase recG FG170_25395 ENOG4105D6U Sodium Glutamate Symporter FG170_25400 ENOG4105C2W permease FG170_25405 ENOG4105JV1 AsmA family FG170_25410 ENOG4105SUU thioesterase domain FG170_25415 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FG170_25420 ENOG4107S2Z UPF0761 membrane protein FG170_25425 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FG170_25440 ENOG4105C5F glutamine synthetase FG170_25445 ENOG4105CUX Signal transduction histidine kinase FG170_25450 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FG170_25455 ENOG4106FIY FG170_25460 ENOG4105D4P Coproporphyrinogen iii oxidase FG170_25470 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FG170_25480 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FG170_25485 ENOG4105C2M dna polymerase I FG170_25490 ENOG4106HNH Acyl-transferase FG170_25495 ENOG4108Z33 Thiol disulfide Interchange Protein FG170_25500 ENOG4105E27 serine threonine protein kinase FG170_25505 ENOG4105PC1 Conserved Protein FG170_25510 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FG170_25515 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FG170_25540 ENOG4107EJG GntR family transcriptional regulator FG170_25545 ENOG4105C0R drug resistance transporter emrb qaca subfamily FG170_25550 ENOG4105ETE Transcriptional regulator (LacI family FG170_25555 ENOG4108RVA ribokinase FG170_25560 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FG170_25565 ENOG4105CNN ABC, transporter FG170_25575 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FG170_25585 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) FG170_25590 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FG170_25595 ENOG4105CU9 asparagine synthetase A FG170_25600 ENOG4108VVK transcriptional Regulator, AsnC FG170_25605 ENOG4105QTB Flavodoxin FG170_25615 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FG170_25620 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FG170_25625 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FG170_25630 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FG170_25635 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FG170_25640 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FG170_25645 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FG170_25650 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FG170_25655 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FG170_25660 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FG170_25665 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FG170_25670 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FG170_25680 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FG170_25685 ENOG4105C8U phosphate abc transporter FG170_25690 ENOG4105E2Z phosphate ABC transporter (Permease FG170_25705 ENOG4106PMH Extracellular solute-binding protein family 3 FG170_25710 ENOG4105EAD ABC transporter FG170_25715 ENOG4105E5Q amino acid AbC transporter FG170_25720 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FG170_25725 ENOG4105M6F mutator MutT protein FG170_25730 ENOG4105C7N Xanthine uracil vitamin C permease FG170_25740 ENOG4108YYH Nadph-dependent fmn reductase FG170_25745 ENOG4107YAK holo-(acyl carrier protein) synthase 2 FG170_25750 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FG170_25755 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FG170_25760 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FG170_25765 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FG170_25770 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FG170_25805 ENOG4105ESI atpase involved in dna repair FG170_25835 ENOG4108RAV Conserved protein FG170_25885 ENOG4108C33 Resolvase FG170_25975 ENOG4107QHF type ii secretion system protein e FG170_25990 ENOG4105K5T PilT protein FG170_26020 ENOG4105CZX twitching motility protein FG170_26145 ENOG4106H6R UPF0380 protein FG170_26155 ENOG4108Z3N Transcriptional regulator FG170_26160 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) FG170_26230 ENOG4107QJE Chromosome Partitioning Protein FG170_26335 ENOG4107QJE Chromosome Partitioning Protein FG170_26405 ENOG41067QW Transcriptional regulator FG170_26585 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FG170_26590 ENOG4105KT5 UmuD protein