locus-tag	class	description
SNE_A00230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SNE_A00240	COG0545	Peptidyl-prolyl cis-trans isomerase
SNE_A00300	COG0477	Major facilitator Superfamily
SNE_A00460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SNE_A00470	COG1192	Involved in chromosome partitioning
SNE_A00490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SNE_A00690	COG0142	geranyltranstransferase activity
SNE_A00740	COG0837	glucose binding
SNE_A00840	COG1448	Aminotransferase
SNE_A00860	COG0517	IMP dehydrogenase activity
SNE_A00860	COG1125	glycine betaine transport
SNE_A00940	COG2217	Heavy metal translocating P-type atpase
SNE_A01000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SNE_A01010	COG1459	type II secretion system
SNE_A01130	COG0742	ribosomal rna small subunit methyltransferase
SNE_A01180	COG1215	transferase activity, transferring glycosyl groups
SNE_A01220	COG0745	RESPONSE REGULATOR receiver
SNE_A01230	COG3103	Sh3 type 3 domain protein
SNE_A01230	COG1388	LysM domain
SNE_A01230	COG0791	NLP P60 protein
SNE_A01250	COG0823	Involved in the tonB-independent uptake of proteins
SNE_A01270	COG0848	biopolymer transport protein
SNE_A01290	COG0084	hydrolase, TatD family'
SNE_A01370	COG1053	succinate dehydrogenase
SNE_A01380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SNE_A01430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SNE_A01540	COG0445	tRNA wobble uridine modification
SNE_A01640	COG0305	Participates in initiation and elongation during chromosome replication
SNE_A01680	COG0494	nUDIX hydrolase
SNE_A01690	COG1164	Oligoendopeptidase f
SNE_A01700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SNE_A01730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SNE_A01780	COG5002	protein histidine kinase activity
SNE_A01890	COG1297	OPT oligopeptide transporter protein
SNE_A01960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SNE_A01980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SNE_A01990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SNE_A02070	COG0653	protein targeting
SNE_A02080	COG0688	phosphatidylethanolamine metabolic process
SNE_A02090	COG1063	alcohol dehydrogenase
SNE_A02120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SNE_A02130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SNE_A02170	COG0632	four-way junction helicase activity
SNE_A02180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SNE_A02210	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SNE_A02230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SNE_A02240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SNE_A02240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SNE_A02310	COG1596	polysaccharide export
SNE_A02340	COG0768	penicillin binding
SNE_A02380	COG0052	Belongs to the universal ribosomal protein uS2 family
SNE_A02390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SNE_A02400	COG0528	UMP kinase activity
SNE_A02410	COG0233	cytoplasmic translational termination
SNE_A02440	COG1619	proteins homologs of microcin C7 resistance protein MccF
SNE_A02450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SNE_A02460	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SNE_A02530	COG1012	belongs to the aldehyde dehydrogenase family
SNE_A02580	COG1091	dTDP-4-dehydrorhamnose reductase activity
SNE_A02600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SNE_A02650	COG0719	Fe-S assembly protein
SNE_A02660	COG0396	ATPase activity
SNE_A02670	COG0719	Fe-S assembly protein
SNE_A02680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SNE_A02890	COG4794	Type iii secretion
SNE_A03020	COG0058	SHG alpha-glucan phosphorylase activity
SNE_A03040	COG0306	phosphate transporter
SNE_A03050	COG1392	Phosphate transport regulator
SNE_A03060	COG1187	pseudouridine synthase activity
SNE_A03070	COG0588	phosphoglycerate mutase activity
SNE_A03120	COG1268	BioY protein
SNE_A03160	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SNE_A03160	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SNE_A03170	COG0772	Belongs to the SEDS family
SNE_A03260	COG0051	transcription antitermination factor activity, RNA binding
SNE_A03270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SNE_A03280	COG0049	tRNA binding
SNE_A03290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SNE_A03310	COG0793	Belongs to the peptidase S41A family
SNE_A03320	COG2815	serine threonine protein kinase
SNE_A03320	COG0515	serine threonine protein kinase
SNE_A03330	COG0789	Transcriptional regulator
SNE_A03340	COG1335	isochorismatase
SNE_A03460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SNE_A03470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SNE_A03480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SNE_A03510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SNE_A03520	COG1121	(ABC) transporter
SNE_A03550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SNE_A03560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SNE_A03570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SNE_A03600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SNE_A03600	COG0116	Belongs to the methyltransferase superfamily
SNE_A03610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SNE_A03620	COG0564	pseudouridine synthase activity
SNE_A03640	COG1301	dicarboxylic acid transport
SNE_A03650	COG0724	RNA recognition motif
SNE_A03660	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SNE_A03680	COG1301	dicarboxylic acid transport
SNE_A03690	COG0508	dehydrogenase complex catalyzes the overall conversion of
SNE_A03720	COG0473	3-isopropylmalate dehydrogenase activity
SNE_A03860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SNE_A03870	COG1862	Preprotein translocase
SNE_A03950	COG0733	neurotransmitter:sodium symporter activity
SNE_A03970	COG2871	sodium ion transport
SNE_A03980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SNE_A03980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SNE_A04050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SNE_A04090	COG0733	neurotransmitter:sodium symporter activity
SNE_A04100	COG0733	neurotransmitter:sodium symporter activity
SNE_A04130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SNE_A04180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SNE_A04200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SNE_A04300	COG2814	Major facilitator Superfamily
SNE_A04320	COG0156	8-amino-7-oxononanoate synthase activity
SNE_A04350	COG0571	ribonuclease III activity
SNE_A04360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SNE_A04370	COG0181	hydroxymethylbilane synthase activity
SNE_A04380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SNE_A04390	COG0756	dUTP diphosphatase activity
SNE_A04400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SNE_A04400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SNE_A04400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SNE_A04500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SNE_A04520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SNE_A04520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SNE_A04520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SNE_A04540	COG0542	response to heat
SNE_A04550	COG0095	Lipoate-protein ligase
SNE_A04620	COG0442	prolyl-tRNA aminoacylation
SNE_A04640	COG2814	Major facilitator Superfamily
SNE_A04670	COG0509	glycine decarboxylation via glycine cleavage system
SNE_A04720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SNE_A04730	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SNE_A04750	COG1805	sodium ion transport
SNE_A04850	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SNE_A04860	COG2814	Major facilitator Superfamily
SNE_A04880	COG0702	epimerase
SNE_A04940	COG2001	Belongs to the MraZ family
SNE_A04950	COG0275	rRNA processing
SNE_A04960	COG0275	rRNA processing
SNE_A04990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SNE_A05000	COG0860	N-Acetylmuramoyl-L-alanine amidase
SNE_A05030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SNE_A05050	COG0481	GTPase activity
SNE_A05060	COG3202	ADP transmembrane transporter activity
SNE_A05100	COG0489	protein tyrosine kinase activity
SNE_A05120	COG0803	Belongs to the bacterial solute-binding protein 9 family
SNE_A05130	COG1121	(ABC) transporter
SNE_A05140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SNE_A05140	COG1321	iron dependent repressor
SNE_A05160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SNE_A05170	COG0750	zinc metalloprotease
SNE_A05230	COG1435	thymidine kinase activity
SNE_A05240	COG2814	Major facilitator Superfamily
SNE_A05290	COG0443	Heat shock 70 kDa protein
SNE_A05320	COG1472	Belongs to the glycosyl hydrolase 3 family
SNE_A05330	COG0443	Heat shock 70 kDa protein
SNE_A05340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SNE_A05350	COG1420	regulation of RNA biosynthetic process
SNE_A05400	COG1362	aminopeptidase activity
SNE_A05450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SNE_A05470	COG0022	dehydrogenase e1 component
SNE_A05550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SNE_A05570	COG1674	ftsk spoiiie
SNE_A05580	COG0658	competence protein
SNE_A05580	COG2333	competence protein COMEC
SNE_A05640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SNE_A05660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SNE_A05690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SNE_A05700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SNE_A05720	COG1480	7TM receptor with intracellular HD hydrolase
SNE_A05730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SNE_A05780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SNE_A05870	COG0459	protein refolding
SNE_A05950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SNE_A05960	COG2814	Major facilitator Superfamily
SNE_A05990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SNE_A06000	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SNE_A06010	COG0037	tRNA processing
SNE_A06020	COG0653	protein targeting
SNE_A06110	COG1166	arginine decarboxylase activity
SNE_A06120	COG0010	Belongs to the arginase family
SNE_A06130	COG1899	peptidyl-lysine modification to peptidyl-hypusine
SNE_A06210	COG2304	oxidoreductase activity
SNE_A06240	COG2155	Conserved Protein
SNE_A06300	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
SNE_A06410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SNE_A06420	COG0659	secondary active sulfate transmembrane transporter activity
SNE_A06440	COG1268	BioY protein
SNE_A06480	COG4285	Biotin-protein ligase, N terminal
SNE_A06500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SNE_A06520	COG2259	Doxx family
SNE_A06530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SNE_A06570	COG0339	signal peptide processing
SNE_A06600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SNE_A06750	COG1252	NADH dehydrogenase
SNE_A06790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SNE_A06800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SNE_A06800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SNE_A06810	COG0534	Mate efflux family protein
SNE_A06820	COG0534	Mate efflux family protein
SNE_A06840	COG2723	6-phospho-beta-galactosidase activity
SNE_A06900	COG0343	queuine tRNA-ribosyltransferase activity
SNE_A06920	COG0668	transmembrane transport
SNE_A06930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SNE_A06940	COG5007	Belongs to the BolA IbaG family
SNE_A07010	COG0039	L-malate dehydrogenase activity
SNE_A07020	COG0372	Belongs to the citrate synthase family
SNE_A07070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SNE_A07070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SNE_A07080	COG0321	lipoyl(octanoyl) transferase activity
SNE_A07080	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SNE_A07090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SNE_A07100	COG2003	Belongs to the UPF0758 family
SNE_A07110	COG2095	MarC family integral membrane protein
SNE_A07120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SNE_A07160	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SNE_A07170	COG1597	lipid kinase activity
SNE_A07190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SNE_A07200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SNE_A07240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SNE_A07260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SNE_A07310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SNE_A07320	COG0671	phosphoesterase, PA-phosphatase related
SNE_A07350	COG0037	tRNA processing
SNE_A07360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SNE_A07490	COG1185	polyribonucleotide nucleotidyltransferase activity
SNE_A07500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SNE_A07530	COG0254	rRNA binding
SNE_A07540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SNE_A07550	COG2890	protein-(glutamine-N5) methyltransferase activity
SNE_A07570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SNE_A07580	COG0228	four-way junction DNA binding
SNE_A07590	COG0336	Belongs to the RNA methyltransferase TrmD family
SNE_A07600	COG0335	large ribosomal subunit rRNA binding
SNE_A07610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SNE_A07640	COG1561	YicC-like family, N-terminal region
SNE_A07650	COG0194	GDP metabolic process
SNE_A07670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SNE_A07670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SNE_A07690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SNE_A07720	COG3153	acetyltransferase
SNE_A07720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SNE_A07830	COG1028	Short-chain dehydrogenase reductase Sdr
SNE_A07850	COG0459	protein refolding
SNE_A07860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SNE_A07870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SNE_A07880	COG1164	Oligoendopeptidase f
SNE_A07890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SNE_A07910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SNE_A07970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SNE_A07980	COG0776	regulation of translation
SNE_A08010	COG0825	malonyl-CoA metabolic process
SNE_A08020	COG1132	(ABC) transporter
SNE_A08100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SNE_A08110	COG0022	dehydrogenase e1 component
SNE_A08110	COG0508	dehydrogenase complex catalyzes the overall conversion of
SNE_A08120	COG0508	dehydrogenase complex catalyzes the overall conversion of
SNE_A08150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SNE_A08170	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SNE_A08180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SNE_A08220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SNE_A08230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SNE_A08240	COG1028	Short-chain dehydrogenase reductase Sdr
SNE_A08250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SNE_A08270	COG2814	Major facilitator Superfamily
SNE_A08300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SNE_A08310	COG1177	transmembrane transport
SNE_A08320	COG1176	ABC-type spermidine putrescine transport system, permease component I
SNE_A08330	COG3842	ATPase activity
SNE_A08340	COG0492	ferredoxin-NADP+ reductase activity
SNE_A08400	COG0736	holo-[acyl-carrier-protein] synthase activity
SNE_A08410	COG4956	integral membrane protein (PIN domain superfamily)
SNE_A08430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SNE_A08440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SNE_A08520	COG0629	single-stranded DNA binding
SNE_A08530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SNE_A08540	COG0564	pseudouridine synthase activity
SNE_A08550	COG3104	oligopeptide transport
SNE_A08560	COG0859	PFAM glycosyl transferase family 9
SNE_A08580	COG0494	nUDIX hydrolase
SNE_A08610	COG3956	TIGRFAM MazG family protein
SNE_A08660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SNE_A08720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SNE_A08720	COG0574	Belongs to the PEP-utilizing enzyme family
SNE_A08730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SNE_A08770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SNE_A08800	COG1271	oxidase subunit
SNE_A08810	COG1294	oxidase, subunit
SNE_A08870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SNE_A08880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SNE_A08890	COG1722	exodeoxyribonuclease VII activity
SNE_A08900	COG1570	exodeoxyribonuclease VII activity
SNE_A08910	COG0149	triose-phosphate isomerase activity
SNE_A08920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SNE_A08930	COG0242	peptide deformylase activity
SNE_A08980	COG0424	maF-like protein
SNE_A09040	COG4692	amylo-alpha-1,6-glucosidase activity
SNE_A09050	COG4535	Mg2 and Co2 transporter CorC
SNE_A09070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SNE_A09100	COG2155	Conserved Protein
SNE_A09110	COG0415	Belongs to the DNA photolyase family
SNE_A09170	COG2094	Belongs to the DNA glycosylase MPG family
SNE_A09180	COG0557	exoribonuclease II activity
SNE_A09210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SNE_A09290	COG1132	(ABC) transporter
SNE_A09300	COG1132	(ABC) transporter
SNE_A09340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SNE_A09350	COG0483	inositol monophosphate 1-phosphatase activity
SNE_A09370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SNE_A09450	COG1136	(ABC) transporter
SNE_A09460	COG4591	ABC-type transport system involved in lipoprotein release permease component
SNE_A09470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SNE_A09480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SNE_A09490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SNE_A09530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SNE_A09550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SNE_A09560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SNE_A09570	COG0504	CTP synthase activity
SNE_A09650	COG1760	l-serine dehydratase
SNE_A09660	COG0205	6-phosphofructokinase activity
SNE_A09700	COG2154	pterin-4-alpha-carbinolamine dehydratase
SNE_A09710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SNE_A09750	COG1473	amidohydrolase
SNE_A09800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SNE_A09810	COG0531	amino acid
SNE_A09830	COG0488	(ABC) transporter
SNE_A09860	COG0778	Nitroreductase
SNE_A09880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SNE_A09900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SNE_A09910	COG0432	Pfam Uncharacterised protein family UPF0047
SNE_A09930	COG0009	L-threonylcarbamoyladenylate synthase
SNE_A09950	COG0406	alpha-ribazole phosphatase activity
SNE_A10070	COG0681	Belongs to the peptidase S26 family
SNE_A10140	COG0402	S-adenosylhomocysteine deaminase activity
SNE_A10150	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
SNE_A10170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SNE_A10170	COG0512	Glutamine amidotransferase of anthranilate synthase
SNE_A10180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SNE_A10210	COG0133	tryptophan synthase activity
SNE_A10230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SNE_A10260	COG0189	ligase activity
SNE_A10270	COG0121	glutamine amidotransferase
SNE_A10310	COG1301	dicarboxylic acid transport
SNE_A10330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SNE_A10340	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SNE_A10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SNE_A10360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SNE_A10370	COG0436	Aminotransferase
SNE_A10400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SNE_A10440	COG1181	Belongs to the D-alanine--D-alanine ligase family
SNE_A10450	COG4166	transmembrane transport
SNE_A10470	COG0534	Mate efflux family protein
SNE_A10480	COG4166	transmembrane transport
SNE_A10490	COG4166	transmembrane transport
SNE_A10520	COG1566	PFAM secretion protein HlyD family protein
SNE_A10530	COG2814	Major facilitator Superfamily
SNE_A10570	COG0515	serine threonine protein kinase
SNE_A10600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SNE_A10610	COG0842	Transport permease protein
SNE_A10620	COG1131	(ABC) transporter
SNE_A10700	COG4166	transmembrane transport
SNE_A10710	COG4166	transmembrane transport
SNE_A10740	COG0477	Major facilitator Superfamily
SNE_A10790	COG1678	Uncharacterized ACR, COG1678
SNE_A10810	COG1127	ABC transporter
SNE_A10820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SNE_A10830	COG3265	gluconokinase activity
SNE_A10860	COG0457	Tetratricopeptide repeat
SNE_A10880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SNE_A10890	COG1030	water channel activity
SNE_A10910	COG4864	UPF0365 protein
SNE_A10950	COG3190	flagellar
SNE_A10950	COG1338	Plays a role in the flagellum-specific transport system
SNE_A10990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SNE_A11000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SNE_A11030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SNE_A11040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SNE_A11050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SNE_A11080	COG0567	Dehydrogenase, E1 component
SNE_A11090	COG0508	dehydrogenase complex catalyzes the overall conversion of
SNE_A11100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SNE_A11180	COG0563	adenylate kinase activity
SNE_A11200	COG4974	Belongs to the 'phage' integrase family
SNE_A11220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SNE_A11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SNE_A11300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SNE_A11310	COG0154	amidase activity
SNE_A11320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SNE_A11350	COG2155	Conserved Protein
SNE_A11360	COG1090	epimerase
SNE_A11390	COG1114	Component of the transport system for branched-chain amino acids
SNE_A11450	COG0251	oxidation-reduction process
SNE_A11480	COG0497	DNA recombination
SNE_A11490	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SNE_A11520	COG1331	Highly conserved protein containing a thioredoxin domain
SNE_A11530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SNE_A11530	COG0515	serine threonine protein kinase
SNE_A11540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SNE_A11560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SNE_A11570	COG0531	amino acid
SNE_A11580	COG1051	belongs to the nudix hydrolase family
SNE_A11600	COG4608	Belongs to the ABC transporter superfamily
SNE_A11610	COG0444	Belongs to the ABC transporter superfamily
SNE_A11620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SNE_A11630	COG0601	transmembrane transport
SNE_A11650	COG1830	Aldolase
SNE_A11720	COG1573	uracil-dna glycosylase
SNE_A11740	COG0564	pseudouridine synthase activity
SNE_A11760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SNE_A11770	COG0693	protein deglycase activity
SNE_A11870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SNE_A11880	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SNE_A11900	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SNE_A11930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SNE_A11940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SNE_A11970	COG1605	Chorismate mutase
SNE_A11970	COG0287	Prephenate dehydrogenase
SNE_A11980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SNE_A12030	COG0471	metal ion transport
SNE_A12060	COG1690	Belongs to the RtcB family
SNE_A12090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SNE_A12100	COG1950	PFAM Membrane protein of
SNE_A12200	COG0730	response to heat
SNE_A12230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SNE_A12240	COG0281	malic enzyme
SNE_A12260	COG0501	Belongs to the peptidase M48B family
SNE_A12270	COG1078	dGTPase activity
SNE_A12280	COG0531	amino acid
SNE_A12290	COG0531	amino acid
SNE_A12320	COG3177	Filamentation induced by cAMP protein fic
SNE_A12350	COG0463	Glycosyl transferase, family 2
SNE_A12440	COG4983	Phage plasmid primase, P4 family domain protein
SNE_A12520	COG0582	viral genome integration into host DNA
SNE_A12540	COG0495	leucyl-tRNA aminoacylation
SNE_A12560	COG0861	Integral membrane protein TerC family
SNE_A12600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SNE_A12610	COG0592	DNA-directed DNA polymerase activity
SNE_A12620	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SNE_A12640	COG0697	spore germination
SNE_A12650	COG0697	spore germination
SNE_A12670	COG0166	Belongs to the GPI family
SNE_A12680	COG0488	(ABC) transporter
SNE_A12720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SNE_A12730	COG0811	peptide transport
SNE_A12780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SNE_A12790	COG2274	protein secretion by the type I secretion system
SNE_A12840	COG3285	dna ligase
SNE_A12840	COG1793	dna ligase
SNE_A12900	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SNE_A12910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SNE_A12950	COG3177	Filamentation induced by cAMP protein fic
SNE_A12980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SNE_A13060	COG3202	ADP transmembrane transporter activity
SNE_A13110	COG0733	neurotransmitter:sodium symporter activity
SNE_A13160	COG1368	sulfuric ester hydrolase activity
SNE_A13180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SNE_A13190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SNE_A13250	COG2239	Acts as a magnesium transporter
SNE_A13260	COG2264	protein methyltransferase activity
SNE_A13270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SNE_A13360	COG2271	Major facilitator Superfamily
SNE_A13380	COG2271	Major facilitator Superfamily
SNE_A13400	COG0482	sulfurtransferase activity
SNE_A13480	COG0728	peptidoglycan biosynthetic process
SNE_A13530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SNE_A13540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SNE_A13550	COG3527	Alpha-acetolactate decarboxylase
SNE_A13560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SNE_A13720	COG2814	Major facilitator Superfamily
SNE_A13730	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SNE_A13750	COG0517	IMP dehydrogenase activity
SNE_A13880	COG1309	transcriptional regulator
SNE_A13890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SNE_A13900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SNE_A13920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SNE_A13940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SNE_A13950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SNE_A13980	COG0613	PHP domain protein
SNE_A13990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SNE_A14000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SNE_A14020	COG0783	Belongs to the Dps family
SNE_A14060	COG2226	methyltransferase
SNE_A14080	COG0470	DNA polymerase III
SNE_A14090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SNE_A14100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SNE_A14110	COG0187	DNA topoisomerase II activity
SNE_A14190	COG2226	methyltransferase
SNE_A14200	COG1169	isochorismate synthase
SNE_A14210	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SNE_A14260	COG1575	Belongs to the MenA family. Type 1 subfamily
SNE_A14280	COG0318	PFAM AMP-dependent synthetase and ligase
SNE_A14330	COG0706	membrane insertase activity
SNE_A14340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SNE_A14440	COG1104	cysteine desulfurase activity
SNE_A14480	COG1253	flavin adenine dinucleotide binding
SNE_A14500	COG0717	Belongs to the dCTP deaminase family
SNE_A14510	COG2255	four-way junction helicase activity
SNE_A14520	COG2385	sporulation resulting in formation of a cellular spore
SNE_A14680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SNE_A14690	COG0180	Tryptophanyl-tRNA synthetase
SNE_A14700	COG0515	serine threonine protein kinase
SNE_A14700	COG0457	Tetratricopeptide repeat
SNE_A14710	COG0525	valine-tRNA ligase activity
SNE_A14750	COG1115	amino acid carrier protein
SNE_A14760	COG1115	amino acid carrier protein
SNE_A14780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SNE_A14790	COG2271	Major facilitator Superfamily
SNE_A14810	COG0494	nUDIX hydrolase
SNE_A14840	COG0114	fumarate hydratase activity
SNE_A14890	COG1269	ATP hydrolysis coupled proton transport
SNE_A14900	COG1394	ATPase activity, coupled to movement of substances
SNE_A14910	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SNE_A14920	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SNE_A14940	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
SNE_A15010	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SNE_A15040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SNE_A15110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SNE_A15120	COG0085	RNA polymerase activity
SNE_A15130	COG0222	ribosome binding
SNE_A15140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SNE_A15150	COG0081	regulation of translation
SNE_A15160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SNE_A15170	COG0250	Participates in transcription elongation, termination and antitermination
SNE_A15190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SNE_A15200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SNE_A15250	COG0006	proline dipeptidase activity
SNE_A15280	COG4286	Uncharacterised protein family (UPF0160)
SNE_A15320	COG0814	amino acid
SNE_A15400	COG2814	Major facilitator Superfamily
SNE_A15410	COG2271	Major facilitator Superfamily
SNE_A15440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SNE_A15450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SNE_A15500	COG1132	(ABC) transporter
SNE_A15530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SNE_A15530	COG0456	acetyltransferase
SNE_A15540	COG0277	FAD linked oxidase domain protein
SNE_A15550	COG0823	Involved in the tonB-independent uptake of proteins
SNE_A15550	COG1506	peptidase
SNE_A15580	COG1673	EVE domain
SNE_A15670	COG0477	Major facilitator Superfamily
SNE_A15780	COG0814	amino acid
SNE_A15790	COG1872	DUF167
SNE_A15850	COG1335	isochorismatase
SNE_A15860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SNE_A15890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SNE_A15990	COG1619	proteins homologs of microcin C7 resistance protein MccF
SNE_A16000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SNE_A16080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SNE_A16090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SNE_A16100	COG2824	Alkylphosphonate utilization operon protein PhnA
SNE_A16120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SNE_A16150	COG2081	HI0933 family
SNE_A16180	COG1309	transcriptional regulator
SNE_A16200	COG0519	Catalyzes the synthesis of GMP from XMP
SNE_A16210	COG2169	Transcriptional regulator
SNE_A16210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SNE_A16230	COG0513	Belongs to the DEAD box helicase family
SNE_A16240	COG0288	reversible hydration of carbon dioxide
SNE_A16250	COG3002	Belongs to the UPF0753 family
SNE_A16260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SNE_A16270	COG0583	DNA-binding transcription factor activity
SNE_A16280	COG0109	protoheme IX farnesyltransferase activity
SNE_A16320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SNE_A16330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SNE_A16390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SNE_A16420	COG3264	Mechanosensitive ion channel
SNE_A16420	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SNE_A16440	COG0789	Transcriptional regulator
SNE_A16450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SNE_A16520	COG1322	Protein conserved in bacteria
SNE_A16540	COG1183	phosphatidylcholine synthase activity
SNE_A16560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SNE_A16560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SNE_A16640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SNE_A16650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SNE_A16720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SNE_A16730	COG0022	dehydrogenase e1 component
SNE_A16790	COG0517	IMP dehydrogenase activity
SNE_A16790	COG1994	Peptidase M50
SNE_A16800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SNE_A16810	COG0045	succinate-CoA ligase (ADP-forming) activity
SNE_A16820	COG0552	protein localization to endoplasmic reticulum
SNE_A16860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SNE_A16900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SNE_A16920	COG0280	phosphate acetyltransferase
SNE_A16920	COG0857	belongs to the CobB CobQ family
SNE_A16930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SNE_A17000	COG0215	cysteine-tRNA ligase activity
SNE_A17070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SNE_A17080	COG0799	negative regulation of ribosome biogenesis
SNE_A17090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SNE_A17140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SNE_A17150	COG1366	Belongs to the anti-sigma-factor antagonist family
SNE_A17160	COG1837	Belongs to the UPF0109 family
SNE_A17200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SNE_A17210	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SNE_A17220	COG2267	carboxylic ester hydrolase activity
SNE_A17250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SNE_A17260	COG0772	Belongs to the SEDS family
SNE_A17280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SNE_A17290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SNE_A17300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SNE_A17380	COG1028	Short-chain dehydrogenase reductase Sdr
SNE_A17400	COG0784	Response regulator, receiver
SNE_A17400	COG2198	Histidine kinase
SNE_A17400	COG5002	protein histidine kinase activity
SNE_A17410	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SNE_A17430	COG0439	Biotin carboxylase
SNE_A17440	COG0511	ligase activity, forming carbon-carbon bonds
SNE_A17450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SNE_A17470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SNE_A17480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SNE_A17500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SNE_A17550	COG0539	negative regulation of cytoplasmic translation
SNE_A17550	COG2183	response to ionizing radiation
SNE_A17560	COG0195	Participates in both transcription termination and antitermination
SNE_A17570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SNE_A17580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SNE_A17590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SNE_A17600	COG0196	riboflavin kinase activity
SNE_A17610	COG0012	GTP binding
SNE_A17640	COG4792	protein secretion
SNE_A17690	COG1640	4-alpha-glucanotransferase
SNE_A17760	COG0542	response to heat
SNE_A17770	COG0542	response to heat
SNE_A17800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SNE_A17810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SNE_A17830	COG0531	amino acid
SNE_A17840	COG2211	Major facilitator Superfamily
SNE_A17880	COG1640	4-alpha-glucanotransferase
SNE_A17910	COG2095	MarC family integral membrane protein
SNE_A17920	COG0101	tRNA pseudouridine synthase activity
SNE_A17930	COG0024	Methionine aminopeptidase
SNE_A17980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SNE_A18030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SNE_A18030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SNE_A18040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SNE_A18050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SNE_A18060	COG0359	binds to the 23S rRNA
SNE_A18070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SNE_A18080	COG0360	Binds together with S18 to 16S ribosomal RNA
SNE_A18090	COG0193	aminoacyl-tRNA hydrolase activity
SNE_A18100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SNE_A18110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SNE_A18140	COG0297	glycogen (starch) synthase activity
SNE_A18150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SNE_A18180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SNE_A18190	COG0751	glycine-tRNA ligase activity
SNE_A18190	COG0752	glycyl-tRNA synthetase alpha subunit
SNE_A18220	COG0358	DNA primase activity
SNE_A18240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SNE_A18280	COG0322	excinuclease ABC activity
SNE_A18340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SNE_A18350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SNE_A18370	COG0594	ribonuclease P activity
SNE_A18380	COG0210	DNA helicase
SNE_A18430	COG3012	SEC-C Motif Domain Protein
SNE_A18440	COG0814	amino acid
SNE_A18450	COG0617	tRNA 3'-terminal CCA addition
SNE_A18470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SNE_A18470	COG3952	Lipid A Biosynthesis
SNE_A18530	COG0416	fatty acid biosynthetic process
SNE_A18540	COG1530	ribonuclease E activity
SNE_A18690	COG0398	Pfam SNARE associated Golgi protein
SNE_A18750	COG0217	transcriptional regulatory protein
SNE_A18780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SNE_A18880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SNE_A18890	COG0101	tRNA pseudouridine synthase activity
SNE_A18910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SNE_A18930	COG2204	response regulator
SNE_A18960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SNE_A19000	COG2604	Protein of unknown function DUF115
SNE_A19090	COG1381	Involved in DNA repair and RecF pathway recombination
SNE_A19150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SNE_A19150	COG0072	phenylalanine-tRNA ligase activity
SNE_A19180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SNE_A19220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SNE_A19230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SNE_A19240	COG0017	Asparaginyl-tRNA synthetase
SNE_A19260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SNE_A19310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SNE_A19320	COG0584	glycerophosphoryl diester phosphodiesterase
SNE_A19370	COG0564	pseudouridine synthase activity
SNE_A19380	COG1837	Belongs to the UPF0109 family
SNE_A19430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SNE_A19460	COG0859	PFAM glycosyl transferase family 9
SNE_A19480	COG0105	UTP biosynthetic process
SNE_A19540	COG1490	D-aminoacyl-tRNA deacylase activity
SNE_A19570	COG1077	Cell shape determining protein MreB Mrl
SNE_A19580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SNE_A19590	COG0544	peptidyl-prolyl cis-trans isomerase activity
SNE_A19600	COG0740	serine-type endopeptidase activity
SNE_A19610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SNE_A20050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SNE_A20060	COG0515	serine threonine protein kinase
SNE_A20060	COG2815	serine threonine protein kinase
SNE_A20150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SNE_A20180	COG1160	GTP binding
SNE_A20210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SNE_A20230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SNE_A20240	COG0686	Belongs to the AlaDH PNT family
SNE_A20250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SNE_A20260	COG0740	serine-type endopeptidase activity
SNE_A20270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SNE_A20280	COG1605	Chorismate mutase
SNE_A20280	COG0077	Prephenate dehydratase
SNE_A20420	COG4974	Belongs to the 'phage' integrase family
SNE_A20430	COG0488	(ABC) transporter
SNE_A20490	COG1234	tRNA 3'-trailer cleavage
SNE_A20530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SNE_A20530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SNE_A20540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SNE_A20550	COG1214	PFAM Peptidase M22, glycoprotease
SNE_A20560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SNE_A20570	COG0484	heat shock protein binding
SNE_A20610	COG0789	Transcriptional regulator
SNE_A20630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SNE_A20660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SNE_A20720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SNE_A20720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SNE_A20780	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
SNE_A20780	COG3264	Mechanosensitive ion channel
SNE_A21020	COG2132	Multicopper oxidase
SNE_A21050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SNE_A21060	COG0203	ribosomal protein L17
SNE_A21070	COG0202	RNA polymerase activity
SNE_A21080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SNE_A21090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SNE_A21110	COG0200	Binds to the 23S rRNA
SNE_A21120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SNE_A21130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SNE_A21140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SNE_A21150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SNE_A21160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SNE_A21170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SNE_A21180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SNE_A21190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SNE_A21200	COG0255	Belongs to the universal ribosomal protein uL29 family
SNE_A21210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SNE_A21220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SNE_A21230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SNE_A21240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SNE_A21250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SNE_A21260	COG0089	rRNA binding
SNE_A21280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SNE_A21380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SNE_A21390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SNE_A21400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SNE_A21410	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
SNE_A21420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SNE_A21440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SNE_A21440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SNE_A21460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SNE_A21500	COG1686	Belongs to the peptidase S11 family
SNE_A21600	COG0587	DNA-directed DNA polymerase activity
SNE_A21650	COG0124	histidyl-tRNA synthetase
SNE_A21660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SNE_A21710	COG3118	belongs to the thioredoxin family
SNE_A21720	COG1564	THIamine pyrophosphokinase
SNE_A21740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SNE_A21750	COG0575	Belongs to the CDS family
SNE_A21770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SNE_A21850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SNE_A21860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SNE_A21860	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SNE_A21870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SNE_A21890	COG0793	Belongs to the peptidase S41A family
SNE_A21940	COG3152	Membrane
SNE_A21950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SNE_A21970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SNE_A21980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SNE_A22000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SNE_A22020	COG1509	lysine 2,3-aminomutase activity
SNE_A22030	COG0018	arginyl-trna synthetase
SNE_A22070	COG0802	atpase or kinase
SNE_A22080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SNE_A22090	COG2176	DNA-directed DNA polymerase activity
SNE_A22100	COG0126	phosphoglycerate kinase activity
SNE_A22110	COG3202	ADP transmembrane transporter activity
SNE_A22140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SNE_A22160	COG1823	symporter activity
SNE_A22190	COG0616	signal peptide processing
SNE_A22200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SNE_A22200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SNE_A22210	COG0237	dephospho-CoA kinase activity
SNE_A22300	COG1482	cell wall glycoprotein biosynthetic process
SNE_A22370	COG0617	tRNA 3'-terminal CCA addition
SNE_A22460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SNE_A22470	COG1162	GTPase activity
SNE_A22490	COG0148	phosphopyruvate hydratase activity
SNE_A22560	COG0450	alkyl hydroperoxide reductase
SNE_A22580	COG2264	protein methyltransferase activity
SNE_A22590	COG0459	protein refolding
SNE_A22610	COG3876	Protein conserved in bacteria
SNE_A22620	COG1012	belongs to the aldehyde dehydrogenase family
SNE_A22680	COG0210	DNA helicase
SNE_A22720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SNE_A22780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SNE_A22820	COG0438	transferase activity, transferring glycosyl groups
SNE_A22840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SNE_A22850	COG0022	dehydrogenase e1 component
SNE_A22940	COG0556	nucleotide-excision repair
SNE_A22950	COG0814	amino acid
SNE_A22990	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SNE_A23010	COG0113	porphobilinogen synthase activity
SNE_A23020	COG1047	Peptidyl-prolyl cis-trans
SNE_A23030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SNE_A23090	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
SNE_A23130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SNE_A23130	COG1747	RNA polymerase binding
SNE_A23140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SNE_A23170	COG4166	transmembrane transport
SNE_A23310	COG0762	integral membrane protein
SNE_A23320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SNE_A23430	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SNE_A23480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SNE_A23510	COG0268	Binds directly to 16S ribosomal RNA
SNE_A23600	COG2027	D-alanyl-D-alanine carboxypeptidase
SNE_A23610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SNE_A23680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SNE_A23720	COG3209	COG3209 Rhs family protein
SNE_B24020	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
SNE_B24240	COG3344	reverse transcriptase
SNE_B24280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SNE_B24370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SNE_B24390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SNE_B24400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SNE_B24410	COG0058	SHG alpha-glucan phosphorylase activity
SNE_B24460	COG2226	methyltransferase
SNE_B24520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SNE_B24530	COG4644	lycopene metabolic process
SNE_B24870	COG0776	regulation of translation
SNE_B24960	COG0305	Participates in initiation and elongation during chromosome replication
SNE_B25030	COG0545	Peptidyl-prolyl cis-trans isomerase
SNE_B25040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SNE_B25090	COG1028	Short-chain dehydrogenase reductase Sdr