locus-tag	class	description
EWH46_00040	ENOG41084EC	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
EWH46_00045	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
EWH46_00050	ENOG41063ZP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
EWH46_00075	ENOG4107QMS	site-determining protein
EWH46_00115	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EWH46_00120	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EWH46_00235	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
EWH46_00245	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
EWH46_00250	ENOG4105W8H	transhydrogenase (subunit alpha
EWH46_00255	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
EWH46_00260	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_00290	ENOG4105BZU	Histidine kinase
EWH46_00295	ENOG4105DWV	Homoserine O-trans-acetylase
EWH46_00300	ENOG4105DWV	Homoserine O-trans-acetylase
EWH46_00310	ENOG4108U78	Glutathione S-transferase
EWH46_00315	ENOG4105DZC	cytosine deaminase
EWH46_00325	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
EWH46_00360	ENOG4106BRA	Membrane
EWH46_00365	ENOG4107HP6	Transcriptional regulator
EWH46_00370	ENOG41072AC	4-hydroxybenzoate 3-monooxygenase
EWH46_00390	ENOG4105E4E	Thioester reductase domain-containing protein
EWH46_00395	ENOG4108IV0	ABC, transporter
EWH46_00400	ENOG4105C0Z	ABC transporter
EWH46_00405	ENOG4105C32	Amino acid ABC transporter (Permease)
EWH46_00410	ENOG4105C32	Amino acid ABC transporter (Permease)
EWH46_00440	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
EWH46_00470	ENOG41060WC	Enoyl-CoA hydratase
EWH46_00475	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EWH46_00485	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_00500	ENOG4105MSY	salicylate hydroxylase
EWH46_00535	ENOG4105CH2	amidohydrolase
EWH46_00590	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_00595	ENOG4105CBC	glutamate synthase
EWH46_00605	ENOG4108KHX	Diguanylate cyclase
EWH46_00620	ENOG4107RJX	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
EWH46_00625	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
EWH46_00630	ENOG410908U	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
EWH46_00645	ENOG4105EW9	transcriptional regulator AsnC family
EWH46_00650	ENOG4105BZU	Histidine kinase
EWH46_00655	ENOG4105BZU	Histidine kinase
EWH46_00670	ENOG4105NWN	ApaG protein
EWH46_00690	ENOG4105DJV	ribulose-phosphate 3-epimerase
EWH46_00700	ENOG410846T	CoA-transferase family III
EWH46_00720	ENOG4105KKX	ATPase associated with various cellular activities aaa_5
EWH46_00730	ENOG4105DEG	Vwa containing coxe family protein
EWH46_00745	ENOG4107RH7	Nicotinate phosphoribosyltransferase
EWH46_00755	ENOG4105CFQ	glutamine synthetase
EWH46_00760	ENOG4105DZ0	fad dependent oxidoreductase
EWH46_00805	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EWH46_00810	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EWH46_00815	ENOG4105EVZ	LysR family transcriptional regulator
EWH46_00825	ENOG4105DDQ	anthranilate synthase
EWH46_00830	ENOG4107QYG	anthranilate phosphoribosyltransferase
EWH46_00835	ENOG4105DK0	Indole-3-glycerol phosphate synthase
EWH46_00840	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
EWH46_00860	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EWH46_00880	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
EWH46_00885	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
EWH46_00890	ENOG4108VZM	50s ribosomal protein L10
EWH46_00895	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
EWH46_00900	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EWH46_00905	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EWH46_00915	ENOG4105DIK	(ABC) transporter
EWH46_00920	ENOG4105CC5	ABC transporter
EWH46_00930	ENOG4105BZU	Histidine kinase
EWH46_00940	ENOG4108I0Y	(ABC) transporter
EWH46_00975	ENOG4106TD9	Diguanylate cyclase
EWH46_00980	ENOG4105BZU	Histidine kinase
EWH46_00985	ENOG4105BZU	Histidine kinase
EWH46_00995	ENOG4105D3Q	Sugar transferase
EWH46_01000	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EWH46_01055	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EWH46_01085	ENOG4105J5G	Transferase hexapeptide repeat containing protein
EWH46_01095	ENOG4105CRK	lysyL-tRNA synthetase
EWH46_01130	ENOG4105E39	Enoyl-CoA hydratase
EWH46_01140	ENOG4105T95	Thiol disulfide interChange protein
EWH46_01145	ENOG4105D0A	hydroxylase
EWH46_01155	ENOG4105C3G	gtp-binding protein
EWH46_01165	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
EWH46_01170	ENOG4105VFU	Rna-binding protein
EWH46_01175	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
EWH46_01190	ENOG4105WH9	RNA polymerase
EWH46_01210	ENOG4106H3A	restriction
EWH46_01215	ENOG4105D9P	serine threonine protein kinase
EWH46_01225	ENOG410600T	transposase
EWH46_01240	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
EWH46_01260	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EWH46_01270	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
EWH46_01275	ENOG4107QTF	adenylosuccinate lyase
EWH46_01285	ENOG4108M3P	Membrane
EWH46_01290	ENOG4105D0M	Protease HtpX homolog
EWH46_01295	ENOG4108M3P	Membrane
EWH46_01325	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
EWH46_01330	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
EWH46_01335	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
EWH46_01340	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
EWH46_01345	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EWH46_01350	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
EWH46_01355	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
EWH46_01360	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
EWH46_01365	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
EWH46_01370	ENOG41084PQ	50s ribosomal protein l29
EWH46_01375	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
EWH46_01390	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
EWH46_01395	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
EWH46_01400	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
EWH46_01405	ENOG4105C3M	thioredoxin reductase
EWH46_01415	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
EWH46_01420	ENOG4105E2X	shikimate dehydrogenase
EWH46_01435	ENOG4105CGH	5'-nucleotidase
EWH46_01440	ENOG4105CHR	reductase
EWH46_01450	ENOG4105DFU	Cell wall formation (By similarity)
EWH46_01455	ENOG4105CTQ	phosphohexokinase
EWH46_01465	ENOG4105CC0	LysR family Transcriptional regulator
EWH46_01470	ENOG4108R4R	Iron-regulated virulence regulatory protein
EWH46_01505	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
EWH46_01530	ENOG4105VCQ	rubredoxin
EWH46_01535	ENOG4108UNF	response regulator
EWH46_01540	ENOG4105M3Z	response regulator
EWH46_01550	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_01555	ENOG4105CBS	Chea signal transduction histidine kinase
EWH46_01560	ENOG4105BZU	Histidine kinase
EWH46_01570	ENOG4108UJU	UPF0301 protein
EWH46_01575	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
EWH46_01580	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
EWH46_01585	ENOG4105CXT	aspartate transcarbamylase
EWH46_01590	ENOG4105CD3	dihydroorotase
EWH46_01595	ENOG4108Z20	Acyl-transferase
EWH46_01605	ENOG4108V1U	phospholipid-binding protein
EWH46_01610	ENOG4105CVJ	phosphoglycerate mutase
EWH46_01615	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
EWH46_01620	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
EWH46_01625	ENOG4105WH1	Two component transcriptional regulator luxr family
EWH46_01630	ENOG4105BZU	Histidine kinase
EWH46_01635	ENOG4105C9A	Phoh family
EWH46_01640	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
EWH46_01650	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
EWH46_01660	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_01685	ENOG4105D5P	Methylmalonyl-coA mutase
EWH46_01690	ENOG4105I5W	Transporter
EWH46_01700	ENOG4105D7T	ABC transporter
EWH46_01710	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
EWH46_01720	ENOG4105BZU	Histidine kinase
EWH46_01725	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
EWH46_01730	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
EWH46_01740	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EWH46_01750	ENOG4105CKI	cobalamin synthesis protein
EWH46_01755	ENOG4108JU5	Magnesium and cobalt efflux protein
EWH46_01760	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
EWH46_01765	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
EWH46_01775	ENOG4105C5H	ABC transporter
EWH46_01785	ENOG4105VPX	protein, conserved in bacteria
EWH46_01810	ENOG41080HT	Transcriptional regulator, arsr family
EWH46_01815	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
EWH46_01820	ENOG4105W2Z	cytochrome C, class I
EWH46_01855	ENOG4105CUC	YeeE YedE family protein
EWH46_01860	ENOG4107S7U	Sulfide dehydrogenase
EWH46_01880	ENOG4105W2Z	cytochrome C, class I
EWH46_01895	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
EWH46_01905	ENOG4105CBN	LysR family transcriptional regulator
EWH46_01930	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_01935	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_01945	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
EWH46_01950	ENOG4105BZU	Histidine kinase
EWH46_01955	ENOG4105FYV	Amp nucleosidase
EWH46_01970	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
EWH46_01980	ENOG4105D7V	transposase
EWH46_01990	ENOG4105DZR	Type I site-specific deoxyribonuclease
EWH46_02040	ENOG4108JJA	ABC, transporter
EWH46_02050	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EWH46_02055	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
EWH46_02065	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
EWH46_02070	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
EWH46_02080	ENOG4105C9X	ppx gppa phosphatase
EWH46_02085	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
EWH46_02110	ENOG4105CEV	competence damage-inducible protein
EWH46_02115	ENOG4105C5F	glutamine synthetase
EWH46_02125	ENOG4105CUX	Signal transduction histidine kinase
EWH46_02130	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EWH46_02145	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EWH46_02150	ENOG4105CHM	Aminotransferase
EWH46_02155	ENOG4105T38	integral membrane protein
EWH46_02160	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EWH46_02165	ENOG4105JAB	phenazine biosynthesis protein, phzf family
EWH46_02180	ENOG4105KY5	gCN5-related N-acetyltransferase
EWH46_02195	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
EWH46_02200	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EWH46_02205	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EWH46_02210	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
EWH46_02215	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
EWH46_02220	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
EWH46_02225	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
EWH46_02230	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
EWH46_02250	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
EWH46_02255	ENOG4105C25	Primosomal protein n'
EWH46_02265	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EWH46_02270	ENOG4105D0A	hydroxylase
EWH46_02305	ENOG4105EQR	Transposase IS116 IS110 IS902
EWH46_02325	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
EWH46_02335	ENOG4105DFH	Transport of potassium into the cell (By similarity)
EWH46_02350	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EWH46_02360	ENOG4105DR5	peptidase
EWH46_02365	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EWH46_02375	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
EWH46_02385	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
EWH46_02400	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EWH46_02420	ENOG4108QV3	biosynthesis protein
EWH46_02440	ENOG4106H78	methyltransferase
EWH46_02445	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
EWH46_02450	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
EWH46_02455	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
EWH46_02460	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
EWH46_02465	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
EWH46_02475	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
EWH46_02490	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
EWH46_02500	ENOG4105CEN	a g-specific adenine glycosylase
EWH46_02510	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
EWH46_02515	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
EWH46_02520	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
EWH46_02525	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
EWH46_02540	ENOG4105EKX	Restriction modification system DNA (Specificity
EWH46_02560	ENOG4105DZR	Type I site-specific deoxyribonuclease
EWH46_02600	ENOG4105PF0	Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin
EWH46_02610	ENOG41067CV	Integrase
EWH46_02620	ENOG4107QHF	type ii secretion system protein e
EWH46_02625	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
EWH46_02675	ENOG4108UUM	single-stranded DNA-binding protein
EWH46_02685	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EWH46_02710	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
EWH46_02715	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
EWH46_02725	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
EWH46_02730	ENOG4105DIH	basic membrane
EWH46_02735	ENOG4108JQ9	ABC transporter
EWH46_02770	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
EWH46_02775	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
EWH46_02790	ENOG4108MN8	Membrane
EWH46_02795	ENOG4108SHN	Glycosyl transferase, family 2
EWH46_02805	ENOG4105FAW	cDP-glucose 4,6-dehydratase
EWH46_02815	ENOG4105EQQ	protein containing aminopeptidase domain
EWH46_02820	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
EWH46_02825	ENOG4107W19	lmbE family
EWH46_02835	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
EWH46_02850	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
EWH46_02855	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
EWH46_02865	ENOG4106NZI	LysR family Transcriptional regulator
EWH46_02880	ENOG4105BZU	Histidine kinase
EWH46_02910	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
EWH46_02950	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EWH46_02980	ENOG4105C6T	cysteine synthase
EWH46_03000	ENOG4108EX3	reductase
EWH46_03005	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
EWH46_03010	ENOG4105CJR	Integral membrane protein (MviN
EWH46_03020	ENOG4105C02	permease
EWH46_03025	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EWH46_03035	ENOG4105DJ0	Poly(A) Polymerase
EWH46_03050	ENOG4107QXV	Phosphate transporter
EWH46_03065	ENOG4105K5M	30s ribosomal protein S16
EWH46_03070	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
EWH46_03075	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
EWH46_03080	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
EWH46_03090	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
EWH46_03100	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
EWH46_03105	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
EWH46_03110	ENOG4105D0M	Protease HtpX homolog
EWH46_03115	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
EWH46_03130	ENOG4105CSU	acyl-Coa dehydrogenase
EWH46_03135	ENOG4108IV0	ABC, transporter
EWH46_03140	ENOG4105C0Z	ABC transporter
EWH46_03165	ENOG4105E9F	Enoyl-CoA hydratase
EWH46_03175	ENOG4105MPD	Cytochrome
EWH46_03180	ENOG4105DP0	ferredoxin-NADP reductase
EWH46_03185	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
EWH46_03195	ENOG41086K9	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EWH46_03200	ENOG4105FUY	alpha subunit
EWH46_03210	ENOG4105KHC	sulfurtransferase
EWH46_03215	ENOG4107YZX	Universal stress protein
EWH46_03235	ENOG410904N	short-chain dehydrogenase reductase
EWH46_03250	ENOG4105CUV	Homoserine Kinase
EWH46_03255	ENOG4105C2M	dna polymerase I
EWH46_03260	ENOG4105VFU	Rna-binding protein
EWH46_03270	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
EWH46_03290	ENOG4108WKG	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
EWH46_03295	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
EWH46_03305	ENOG4105CQM	Urea amidohydrolase subunit alpha
EWH46_03310	ENOG4105KI2	Urea amidohydrolase subunit beta
EWH46_03320	ENOG4108YZ9	Urea amidohydrolase subunit gamma
EWH46_03325	ENOG4105BZU	Histidine kinase
EWH46_03330	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EWH46_03335	ENOG4107R6F	Alpha Beta Hydrolase Fold protein
EWH46_03340	ENOG4105BZU	Histidine kinase
EWH46_03355	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
EWH46_03360	ENOG4107TSX	ABC branched chain amino acid family transporter periplasmic ligand binding protein
EWH46_03365	ENOG4105C32	Amino acid ABC transporter (Permease)
EWH46_03370	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
EWH46_03375	ENOG4105C0Z	ABC transporter
EWH46_03380	ENOG4108IV0	ABC, transporter
EWH46_03405	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_03425	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
EWH46_03450	ENOG4105CWB	LysR family transcriptional Regulator
EWH46_03455	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
EWH46_03460	ENOG4108V1T	peptidylprolyl cis-trans isomerase
EWH46_03465	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
EWH46_03475	ENOG4105D85	methylase
EWH46_03480	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
EWH46_03490	ENOG4108WQI	RNA Polymerase
EWH46_03500	ENOG4105E18	UPF0276 protein
EWH46_03520	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
EWH46_03525	ENOG4105E66	phosphoriboisomerase A
EWH46_03540	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EWH46_03545	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
EWH46_03550	ENOG4105UYK	outer membrane protein a
EWH46_03555	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EWH46_03565	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
EWH46_03575	ENOG4105EVN	Prephenate dehydrogenase
EWH46_03580	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
EWH46_03585	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
EWH46_03590	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
EWH46_03600	ENOG4105CFV	Tetratricopeptide repeat protein
EWH46_03620	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
EWH46_03635	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
EWH46_03640	ENOG4105D7T	ABC transporter
EWH46_03645	ENOG4107Z6I	Thiamine biosynthesis protein
EWH46_03660	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
EWH46_03665	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
EWH46_03670	ENOG4105DY8	decarboxylase
EWH46_03685	ENOG4107QHF	type ii secretion system protein e
EWH46_03690	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
EWH46_03700	ENOG4105DQR	SNARE associated Golgi
EWH46_03710	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
EWH46_03715	ENOG4105K8N	protein family UPF0079, ATPase
EWH46_03720	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
EWH46_03735	ENOG4108Z9W	Outer membrane porin
EWH46_03740	ENOG4105E5Q	amino acid AbC transporter
EWH46_03745	ENOG4105BZU	Histidine kinase
EWH46_03750	ENOG4106PMH	Extracellular solute-binding protein family 3
EWH46_03755	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
EWH46_03760	ENOG4108Z0R	Transferase
EWH46_03765	ENOG4105ED9	Protein of unknown function (DUF455)
EWH46_03770	ENOG4105EXC	Acyl-transferase
EWH46_03785	ENOG4105CQB	FAD linked oxidase domain protein
EWH46_03790	ENOG4105EU8	FAD linked oxidase domain protein
EWH46_03795	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EWH46_03800	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
EWH46_03805	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
EWH46_03810	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
EWH46_03815	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
EWH46_03820	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
EWH46_03825	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
EWH46_03845	ENOG4108MUZ	hydrolase
EWH46_03855	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
EWH46_03880	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
EWH46_03885	ENOG4105D7W	serine acetyltransferase
EWH46_03900	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
EWH46_03905	ENOG4105N42	UPF0307 protein
EWH46_03910	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
EWH46_03915	ENOG4105CH5	extracellular solute-binding protein, family 7
EWH46_03920	ENOG4105CH5	extracellular solute-binding protein, family 7
EWH46_03950	ENOG4108IPJ	Membrane
EWH46_04010	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EWH46_04025	ENOG4105CS6	Rhs element vgr protein
EWH46_04035	ENOG4105CNA	YD repeat protein
EWH46_04095	ENOG4108IJF	Heavy metal efflux pump, CzcA
EWH46_04150	ENOG4108V5V	Serine Threonine protein kinase
EWH46_04165	ENOG4108ZF3	Phosphatase
EWH46_04180	ENOG4105UYK	outer membrane protein a
EWH46_04195	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
EWH46_04205	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
EWH46_04220	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
EWH46_04225	ENOG4105DTN	riboflavin biosynthesis protein ribF
EWH46_04230	ENOG4105I08	Pseudouridine synthase
EWH46_04240	ENOG4105X7H	acyl-CoA dehydrogenase
EWH46_04245	ENOG4105X7H	acyl-CoA dehydrogenase
EWH46_04255	ENOG4108VPT	UPF0234 protein
EWH46_04260	ENOG4105D4A	Cell wall formation (By similarity)
EWH46_04265	ENOG4105K6T	rare lipoprotein A
EWH46_04285	ENOG4105CHH	sulfate transporter
EWH46_04300	ENOG4108QCI	YvbH-like oligomerisation region
EWH46_04310	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
EWH46_04320	ENOG4105BZU	Histidine kinase
EWH46_04350	ENOG4108IEG	Formate dehydrogenase Alpha subunit
EWH46_04375	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
EWH46_04380	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EWH46_04390	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_04395	ENOG4108Z7G	MaoC domain protein dehydratase
EWH46_04405	ENOG4105BZU	Histidine kinase
EWH46_04410	ENOG4105W2Z	cytochrome C, class I
EWH46_04415	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
EWH46_04430	ENOG4105CB5	ATP-dependent DNA helicase recG
EWH46_04450	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
EWH46_04460	ENOG4105EUB	pirin domain protein
EWH46_04465	ENOG4105DDV	Transcriptional regulator (LacI family
EWH46_04490	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_04505	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
EWH46_04550	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
EWH46_04555	ENOG4105BZU	Histidine kinase
EWH46_04585	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
EWH46_04595	ENOG4105BZ1	(ABC) transporter
EWH46_04610	ENOG4105BZU	Histidine kinase
EWH46_04615	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EWH46_04620	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
EWH46_04625	ENOG4105C2C	drug resistance transporter, Bcr CflA
EWH46_04635	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
EWH46_04645	ENOG41060WC	Enoyl-CoA hydratase
EWH46_04650	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_04655	ENOG4105CVE	Lytic murein transglycosylase
EWH46_04660	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
EWH46_04675	ENOG4105EAH	synthase
EWH46_04680	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
EWH46_04685	ENOG4105K46	50S ribosomal protein l27
EWH46_04690	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EWH46_04695	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
EWH46_04705	ENOG4105C3R	Methionine synthase
EWH46_04710	ENOG4105C3R	Methionine synthase
EWH46_04720	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EWH46_04755	ENOG4105CQB	FAD linked oxidase domain protein
EWH46_04760	ENOG4105EU8	FAD linked oxidase domain protein
EWH46_04765	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EWH46_04775	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
EWH46_04785	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
EWH46_04795	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
EWH46_04815	ENOG4108JU3	Alkyl hydroperoxide reductase
EWH46_04825	ENOG41090R7	Ferric uptake
EWH46_04855	ENOG4107E2E	PKHD-type hydroxylase
EWH46_04890	ENOG4105DHP	deoxycytidine triphosphate deaminase
EWH46_04915	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
EWH46_04920	ENOG4108ZC9	flagellar basal-body rod protein flgc
EWH46_04925	ENOG4105W00	Flagellar hook capping protein
EWH46_04930	ENOG4105BZE	flagellar hook protein, FlgE
EWH46_04935	ENOG4108KPB	Flagellar basal-body rod protein FlgF
EWH46_04940	ENOG4105CGA	flagellar basal-body rod protein FlgG
EWH46_04950	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
EWH46_04955	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
EWH46_04960	ENOG4105E1Q	flagellar hook-associated protein
EWH46_04970	ENOG4105D58	Diguanylate phosphodiesterase
EWH46_04990	ENOG4105BZU	Histidine kinase
EWH46_04995	ENOG4105BZU	Histidine kinase
EWH46_05005	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
EWH46_05010	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
EWH46_05040	ENOG4105CPC	Aldo Keto reductase
EWH46_05050	ENOG4105M4H	endoribonuclease L-psp
EWH46_05055	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
EWH46_05060	ENOG4108Z66	YbaK ebsC protein
EWH46_05065	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
EWH46_05070	ENOG4105DB7	PHP domain protein
EWH46_05075	ENOG4105D8V	Glucose sorbosone dehydrogenase
EWH46_05080	ENOG4105BZU	Histidine kinase
EWH46_05090	ENOG4105ETT	transcriptional Regulator, LysR family
EWH46_05095	ENOG4105C1G	acyl-Coa dehydrogenase
EWH46_05100	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
EWH46_05110	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EWH46_05115	ENOG4105CFG	Acts as a chaperone (By similarity)
EWH46_05120	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EWH46_05135	ENOG4105VEJ	Heat shock protein
EWH46_05140	ENOG4105DHQ	Histidine kinase
EWH46_05175	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
EWH46_05195	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EWH46_05210	ENOG4105BZU	Histidine kinase
EWH46_05220	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EWH46_05230	ENOG4107R3E	Citrate transporter
EWH46_05235	ENOG4105CB5	ATP-dependent DNA helicase recG
EWH46_05245	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
EWH46_05255	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
EWH46_05260	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
EWH46_05265	ENOG4105W49	UPF0434 protein
EWH46_05270	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
EWH46_05275	ENOG4105M15	transport protein ExbD
EWH46_05285	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
EWH46_05290	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
EWH46_05295	ENOG4107S11	squalene-associated FAD-dependent desaturase
EWH46_05310	ENOG4105BZS	acriflavin resistance protein
EWH46_05320	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
EWH46_05325	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
EWH46_05330	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
EWH46_05335	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EWH46_05365	ENOG4105CDU	Replicative dna helicase
EWH46_05375	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
EWH46_05380	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EWH46_05390	ENOG4105HBR	Rna-binding protein
EWH46_05395	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
EWH46_05400	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EWH46_05410	ENOG4105BZJ	Electron transfer flavoprotein
EWH46_05415	ENOG4105C10	Electron transfer flavoprotein
EWH46_05420	ENOG4105CSU	acyl-Coa dehydrogenase
EWH46_05430	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EWH46_05435	ENOG4105BZU	Histidine kinase
EWH46_05440	ENOG4105CBS	Chea signal transduction histidine kinase
EWH46_05460	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_05465	ENOG4105E6M	Sulphatase-modifying factor protein
EWH46_05470	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
EWH46_05485	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
EWH46_05495	ENOG4105DZG	Dehydrogenase
EWH46_05500	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EWH46_05510	ENOG4105CDA	abc transporter atp-binding protein
EWH46_05520	ENOG4105BZ8	glutamate synthase
EWH46_05525	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
EWH46_05560	ENOG4105CHB	tonB-dependent Receptor
EWH46_05565	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
EWH46_05575	ENOG4105BZU	Histidine kinase
EWH46_05590	ENOG4105EUJ	GTP cyclohydrolase i
EWH46_05595	ENOG4108Z86	Glutamine amidotransferase
EWH46_05600	ENOG4105BZU	Histidine kinase
EWH46_05605	ENOG4105BZU	Histidine kinase
EWH46_05615	ENOG4105CSH	Transporter
EWH46_05645	ENOG4105BZU	Histidine kinase
EWH46_05655	ENOG4105CAY	ferredoxin--nadp reductase
EWH46_05660	ENOG4108Z4U	Ferredoxin
EWH46_05665	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
EWH46_05670	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
EWH46_05675	ENOG4105C11	sulfate adenylyltransferase), subunit 2
EWH46_05680	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
EWH46_05695	ENOG4107TSN	permease
EWH46_05705	ENOG4105C59	p-type ATPase
EWH46_05715	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
EWH46_05750	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
EWH46_05755	ENOG4105D4P	Coproporphyrinogen iii oxidase
EWH46_05770	ENOG4105VEQ	Cold shock protein
EWH46_05775	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
EWH46_05780	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EWH46_05785	ENOG4105VCQ	rubredoxin
EWH46_05790	ENOG4105EXZ	Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity)
EWH46_05795	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
EWH46_05800	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
EWH46_05815	ENOG4105C8N	cysteinyl-tRNA synthetase
EWH46_05830	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
EWH46_05835	ENOG4105CFH	Aspartokinase
EWH46_05855	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EWH46_05860	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
EWH46_05865	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
EWH46_05870	ENOG4107QJH	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
EWH46_05880	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
EWH46_05885	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
EWH46_05890	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
EWH46_05895	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
EWH46_05900	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
EWH46_05905	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
EWH46_05920	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
EWH46_05925	ENOG4105C28	cystathionine
EWH46_05930	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
EWH46_05980	ENOG4105D16	lipopolysaccharide heptosyltransferase i
EWH46_05990	ENOG4105DFG	type I secretion outer membrane protein
EWH46_06000	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
EWH46_06010	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
EWH46_06015	ENOG4105YA8	Transcriptional regulator
EWH46_06030	ENOG4105C1J	atp-dependent rna helicase
EWH46_06040	ENOG4105D64	Mechanosensitive ion channel
EWH46_06050	ENOG4105BZU	Histidine kinase
EWH46_06060	ENOG4105WQ3	Rna-binding protein
EWH46_06110	ENOG4105BZU	Histidine kinase
EWH46_06125	ENOG4105CCT	upf0313 protein
EWH46_06135	ENOG4105BZ1	(ABC) transporter
EWH46_06140	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
EWH46_06145	ENOG4107QMS	site-determining protein
EWH46_06150	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
EWH46_06155	ENOG4105PNM	synthesis protein
EWH46_06160	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
EWH46_06165	ENOG4108JQC	penicillin-binding protein 1A
EWH46_06170	ENOG4105F1N	DNA alkylation repair
EWH46_06180	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
EWH46_06185	ENOG4105WH1	Two component transcriptional regulator luxr family
EWH46_06200	ENOG4105KTH	gatB Yqey
EWH46_06205	ENOG4105VCC	30S ribosomal protein S21
EWH46_06210	ENOG4105CBX	hi0933 family
EWH46_06235	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
EWH46_06240	ENOG4105CJ1	ABC, transporter
EWH46_06280	ENOG4105JN3	extra-cytoplasmic solute receptor family protein
EWH46_06285	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
EWH46_06290	ENOG4105CFI	type iii restriction protein res subunit
EWH46_06295	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
EWH46_06305	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
EWH46_06310	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
EWH46_06320	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
EWH46_06330	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
EWH46_06340	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
EWH46_06345	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
EWH46_06350	ENOG4108K5P	(LipO)protein
EWH46_06355	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
EWH46_06375	ENOG4105M8F	Biopolymer transport protein exbD tolR
EWH46_06380	ENOG4105E02	MotA TolQ exbB proton channel
EWH46_06385	ENOG4107YD3	Thioesterase
EWH46_06395	ENOG4105CHM	Aminotransferase
EWH46_06400	ENOG4107YIM	Involved in the transcription termination process (By similarity)
EWH46_06405	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
EWH46_06410	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
EWH46_06415	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
EWH46_06445	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
EWH46_06450	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
EWH46_06455	ENOG4105E4C	Lytic transglycosylase catalytic
EWH46_06460	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
EWH46_06470	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
EWH46_06475	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EWH46_06490	ENOG4105C01	Dihydroxy-acid dehydratase
EWH46_06495	ENOG4108UHU	Aldolase
EWH46_06520	ENOG4105D6S	protein involved in catabolism of external DNA
EWH46_06525	ENOG4105CYC	Transferase
EWH46_06530	ENOG4107SDU	Methyl-accepting chemotaxis
EWH46_06535	ENOG4107SDU	Methyl-accepting chemotaxis
EWH46_06540	ENOG4108V3W	Chemotaxis protein, CheW
EWH46_06545	ENOG4105C0D	helicase
EWH46_06550	ENOG4108UYE	Lactoylglutathione lyase
EWH46_06555	ENOG4105F8C	transglutaminase domain-containing protein
EWH46_06565	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
EWH46_06610	ENOG4105C5H	ABC transporter
EWH46_06615	ENOG4108YZA	Nitrogen regulatory protein pii
EWH46_06620	ENOG41080IJ	Diacylglycerol kinase
EWH46_06645	ENOG4105C7K	acetolactate synthase
EWH46_06650	ENOG4108ZP8	Acetolactate synthase small subunit
EWH46_06655	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
EWH46_06665	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
EWH46_06670	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
EWH46_06675	ENOG41061WM	D-Alanyl-D-Alanine
EWH46_06680	ENOG4108N16	Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region
EWH46_06690	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
EWH46_06695	ENOG4105C7S	Dehydrogenase
EWH46_06700	ENOG4107QN2	dihydrolipoyl dehydrogenase
EWH46_06705	ENOG4105D6Z	AFG1 family ATPase
EWH46_06710	ENOG4108ZF3	Phosphatase
EWH46_06720	ENOG4105DVT	helicase
EWH46_06730	ENOG4105C34	Pseudouridine synthase
EWH46_06735	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
EWH46_06740	ENOG4105FE9	pseudouridine synthase
EWH46_06745	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
EWH46_06750	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
EWH46_06765	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
EWH46_06770	ENOG4105CUT	histidyl-tRNA synthetase
EWH46_06785	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
EWH46_06790	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
EWH46_06795	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
EWH46_06800	ENOG4107QJR	hflk protein
EWH46_06805	ENOG4105EPW	hflc protein
EWH46_06815	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
EWH46_06820	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
EWH46_06825	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
EWH46_06845	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
EWH46_06850	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
EWH46_06865	ENOG4105CE9	30S ribosomal protein S2
EWH46_06870	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
EWH46_06875	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
EWH46_06880	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
EWH46_06890	ENOG4105KNE	Phosphatidate cytidylyltransferase
EWH46_06895	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
EWH46_06900	ENOG4105DZP	Membrane-associated zinc metalloprotease
EWH46_06905	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWH46_06915	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EWH46_06920	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
EWH46_06925	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EWH46_06930	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EWH46_06935	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EWH46_06945	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
EWH46_06960	ENOG4107QN1	sodium solute
EWH46_06965	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
EWH46_06975	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
EWH46_06980	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
EWH46_06985	ENOG4105EEI	dihydropteroate synthase
EWH46_06990	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
EWH46_07000	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
EWH46_07005	ENOG4105C8U	phosphate abc transporter
EWH46_07010	ENOG4105E2Z	phosphate ABC transporter (Permease
EWH46_07015	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
EWH46_07025	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EWH46_07030	ENOG4105BZU	Histidine kinase
EWH46_07040	ENOG4105NRA	50s ribosomal protein l31 type b
EWH46_07045	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
EWH46_07055	ENOG4105K63	Thioredoxin
EWH46_07065	ENOG4105EYA	deoxyribonuclease
EWH46_07080	ENOG4107QHF	type ii secretion system protein e
EWH46_07100	ENOG4107SFI	Major Facilitator superfamily
EWH46_07115	ENOG4105EQR	Transposase IS116 IS110 IS902
EWH46_07125	ENOG4105EQR	Transposase IS116 IS110 IS902
EWH46_07160	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EWH46_07175	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
EWH46_07180	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_07185	ENOG4105CN1	protease
EWH46_07190	ENOG4105D06	uba thif-type nad fad binding protein
EWH46_07210	ENOG4105K64	Glycosyl transferase, family 2
EWH46_07230	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EWH46_07235	ENOG4105BZU	Histidine kinase
EWH46_07250	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
EWH46_07255	ENOG4105CHV	Transcription elongation factor NusA
EWH46_07260	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
EWH46_07265	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
EWH46_07270	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
EWH46_07275	ENOG4105CI3	gtp-binding protein typa
EWH46_07295	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
EWH46_07305	ENOG4107VRP	DNA repair exonuclease
EWH46_07310	ENOG4107WZZ	SMC domain protein
EWH46_07320	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
EWH46_07325	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
EWH46_07330	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
EWH46_07340	ENOG4105DRS	transport system, permease
EWH46_07360	ENOG4108IJ9	(ABC) transporter
EWH46_07380	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_07385	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_07390	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_07395	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
EWH46_07405	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
EWH46_07425	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
EWH46_07430	ENOG4108Z1B	Cyclase dehydrase
EWH46_07435	ENOG4105VDB	UPF0125 protein
EWH46_07445	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
EWH46_07455	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
EWH46_07470	ENOG4105EQR	Transposase IS116 IS110 IS902
EWH46_07480	ENOG4108YQE	rare lipoprotein a
EWH46_07490	ENOG4108YZN	class I peptide chain release factor
EWH46_07505	ENOG4107FQ9	ethanolamine ammonia-lyase
EWH46_07510	ENOG4105CPD	ethanolamine ammonia-lyase
EWH46_07515	ENOG4105CUB	amino acid
EWH46_07535	ENOG4108ZCF	integral membrane protein
EWH46_07550	ENOG4105CXN	decarboxylase
EWH46_07555	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
EWH46_07570	ENOG4105CFG	Acts as a chaperone (By similarity)
EWH46_07575	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
EWH46_07585	ENOG4105DJ4	phosphatidylserine decarboxylase
EWH46_07590	ENOG4105BZU	Histidine kinase
EWH46_07610	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
EWH46_07635	ENOG4108RH0	Crea protein
EWH46_07660	ENOG4105BZU	Histidine kinase
EWH46_07695	ENOG4105BZU	Histidine kinase
EWH46_07710	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EWH46_07730	ENOG4105WZK	nitrite reductase NADPH small subunit
EWH46_07735	ENOG4107QZF	nitrite reductase NADPH large subunit
EWH46_07770	ENOG4108IAB	Phoh family
EWH46_07775	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EWH46_07785	ENOG4105CHM	Aminotransferase
EWH46_07790	ENOG4105D6E	homoserine dehydrogenase
EWH46_07810	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
EWH46_07815	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
EWH46_07825	ENOG4108ZAF	Molybdopterin
EWH46_07835	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
EWH46_07840	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
EWH46_07845	ENOG4108YZY	peptidylprolyl cis-trans isomerase
EWH46_07850	ENOG4105EZE	Cupin 4 family protein
EWH46_07860	ENOG4105GJM	(LipO)protein
EWH46_07865	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
EWH46_07870	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EWH46_07880	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EWH46_07885	ENOG4105WH1	Two component transcriptional regulator luxr family
EWH46_07905	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EWH46_07910	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
EWH46_07915	ENOG4105DHQ	Histidine kinase
EWH46_07940	ENOG4108EC8	DNA internalization-related competence protein ComEC
EWH46_07960	ENOG4105NPQ	Pfam:DUF403
EWH46_07985	ENOG4105IJJ	transcriptional regulator, crp fnr family
EWH46_07995	ENOG4105CHM	Aminotransferase
EWH46_08000	ENOG4107R11	Transcriptional regulator
EWH46_08020	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
EWH46_08045	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EWH46_08050	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_08060	ENOG4105BZU	Histidine kinase
EWH46_08065	ENOG4105D7V	transposase
EWH46_08085	ENOG4105C5H	ABC transporter
EWH46_08090	ENOG4105CVE	Lytic murein transglycosylase
EWH46_08105	ENOG4105BZU	Histidine kinase
EWH46_08110	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
EWH46_08120	ENOG4105CHR	reductase
EWH46_08125	ENOG4108YXG	UPF0502 protein
EWH46_08130	ENOG4107QSV	RmuC domain protein
EWH46_08135	ENOG4108EPX	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
EWH46_08145	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
EWH46_08150	ENOG4105C28	cystathionine
EWH46_08160	ENOG4105BZU	Histidine kinase
EWH46_08165	ENOG4105CQ7	ATP-dependent helicase
EWH46_08180	ENOG4105NWF	RbsD or FucU transport
EWH46_08185	ENOG4105C2J	ABC transporter
EWH46_08190	ENOG4105CNN	ABC, transporter
EWH46_08195	ENOG4107R5G	Periplasmic binding protein LacI transcriptional regulator
EWH46_08210	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_08280	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EWH46_08285	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
EWH46_08290	ENOG4105C4M	(Ubiquinol oxidase) subunit I
EWH46_08315	ENOG4105CYW	agmatinase
EWH46_08320	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
EWH46_08325	ENOG4108I9X	Isocitrate lyase
EWH46_08330	ENOG4105C22	threonyL-tRNA synthetase
EWH46_08335	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
EWH46_08340	ENOG4105VJV	50s ribosomal protein L35
EWH46_08345	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
EWH46_08350	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
EWH46_08355	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
EWH46_08360	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
EWH46_08405	ENOG4108IYU	L-aspartate oxidase
EWH46_08420	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
EWH46_08435	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
EWH46_08440	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
EWH46_08450	ENOG4105EAC	phosphoserine phosphatase
EWH46_08460	ENOG4106P55	Transcriptional regulator
EWH46_08465	ENOG4105BZU	Histidine kinase
EWH46_08470	ENOG4108UXN	response regulator
EWH46_08485	ENOG4105C1G	acyl-Coa dehydrogenase
EWH46_08490	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
EWH46_08495	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EWH46_08500	ENOG4105C26	Dehydrogenase
EWH46_08535	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EWH46_08550	ENOG4105CXN	decarboxylase
EWH46_08555	ENOG4105UEI	Transcriptional Regulator AraC Family
EWH46_08560	ENOG4105DXC	membrane
EWH46_08575	ENOG4105CG3	alpha amylase, catalytic region
EWH46_08585	ENOG4108IUM	Glycogen debranching enzyme
EWH46_08590	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
EWH46_08595	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
EWH46_08600	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
EWH46_08605	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
EWH46_08615	ENOG4108SHN	Glycosyl transferase, family 2
EWH46_08620	ENOG4108VUY	thioesterase Superfamily protein
EWH46_08625	ENOG4105E5K	Alpha-amylase
EWH46_08670	ENOG4105C5I	Dehydrogenase
EWH46_08675	ENOG4105F27	Major Facilitator
EWH46_08695	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
EWH46_08700	ENOG4105C2N	RNA methyltransferase TrmH family group 3
EWH46_08705	ENOG4108I0Y	(ABC) transporter
EWH46_08710	ENOG4108UJV	acyl-CoA thioesterase i
EWH46_08735	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EWH46_08740	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
EWH46_08745	ENOG4105DTD	Dehydrogenase
EWH46_08755	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EWH46_08760	ENOG4105E0F	Histidine kinase
EWH46_08765	ENOG4105BZU	Histidine kinase
EWH46_08775	ENOG4105CFP	Peptidase U32
EWH46_08785	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
EWH46_08790	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EWH46_08795	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
EWH46_08800	ENOG4105E9H	Lytic Murein transglycosylase
EWH46_08805	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
EWH46_08810	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
EWH46_08815	ENOG4107QMP	dna polymerase iii subunits gamma and tau
EWH46_08820	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
EWH46_08825	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
EWH46_08830	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
EWH46_08835	ENOG4107QNJ	CoA-transferase subunit B
EWH46_08845	ENOG4108ZXC	Two component transcriptional regulator, luxr family
EWH46_08850	ENOG4105F8V	Hydrolase, tatD family
EWH46_08860	ENOG4107QRG	dna polymerase iii
EWH46_08865	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
EWH46_08870	ENOG4105HHA	aminodeoxychorismate lyase
EWH46_08875	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
EWH46_08895	ENOG4105DJ9	glucan biosynthesis protein
EWH46_08920	ENOG4105DGU	Histone deacetylase
EWH46_08925	ENOG4108WFY	phasin family
EWH46_08940	ENOG4108WFY	phasin family
EWH46_08945	ENOG4105DP8	Major facilitator superfamily MFS_1
EWH46_08975	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
EWH46_08980	ENOG4105BZM	domain protein
EWH46_08985	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_09000	ENOG4105CAU	Arsenical resistance protein, ArsH
EWH46_09005	ENOG4105DTD	Dehydrogenase
EWH46_09010	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
EWH46_09025	ENOG4105CHR	reductase
EWH46_09030	ENOG4105CSU	acyl-Coa dehydrogenase
EWH46_09035	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_09040	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EWH46_09060	ENOG4108IV0	ABC, transporter
EWH46_09065	ENOG4105C0Z	ABC transporter
EWH46_09075	ENOG4105C32	Amino acid ABC transporter (Permease)
EWH46_09090	ENOG4105CNG	UPF0061 protein
EWH46_09095	ENOG4107835	probably involved in intracellular septation (By similarity)
EWH46_09105	ENOG4107TF3	peptidylprolyl cis-trans isomerase
EWH46_09110	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
EWH46_09120	ENOG4108JPW	Aminotransferase
EWH46_09125	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_09135	ENOG4105F38	ABC transporter, permease
EWH46_09140	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
EWH46_09145	ENOG4105CYW	agmatinase
EWH46_09185	ENOG4105CVR	type I restriction-modification system
EWH46_09205	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EWH46_09220	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
EWH46_09230	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
EWH46_09235	ENOG4105BZS	acriflavin resistance protein
EWH46_09240	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
EWH46_09250	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EWH46_09255	ENOG4105CQZ	Histidine kinase
EWH46_09260	ENOG4105CDA	abc transporter atp-binding protein
EWH46_09265	ENOG4105DRP	amino acid AbC transporter
EWH46_09270	ENOG4105EAD	ABC transporter
EWH46_09275	ENOG4107RP9	extracellular solute-binding protein, family 3
EWH46_09280	ENOG4107RP9	extracellular solute-binding protein, family 3
EWH46_09300	ENOG4108QDE	fad dependent oxidoreductase
EWH46_09305	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
EWH46_09310	ENOG4105CHR	reductase
EWH46_09355	ENOG4108EKC	n-acetylglutamate synthase
EWH46_09360	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
EWH46_09370	ENOG4107M1U	Histone family protein nucleoid-structuring protein H-NS
EWH46_09375	ENOG4105K4H	Nlp p60 protein
EWH46_09380	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EWH46_09385	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
EWH46_09395	ENOG4108ECM	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity)
EWH46_09405	ENOG4108JA2	transcriptioN-repair coupling factor
EWH46_09415	ENOG4105DXM	phenylacetic acid degradation protein
EWH46_09430	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
EWH46_09435	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
EWH46_09440	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
EWH46_09445	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
EWH46_09450	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
EWH46_09460	ENOG4108ZJI	phenylacetic acid degradation protein
EWH46_09465	ENOG4108UKI	Enoyl-CoA hydratase
EWH46_09475	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
EWH46_09480	ENOG4108Z6B	deaminase
EWH46_09495	ENOG4105CJP	fad dependent oxidoreductase
EWH46_09500	ENOG4108Z86	Glutamine amidotransferase
EWH46_09505	ENOG4105CFQ	glutamine synthetase
EWH46_09510	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EWH46_09515	ENOG4105EQR	Transposase IS116 IS110 IS902
EWH46_09530	ENOG4105C26	Dehydrogenase
EWH46_09535	ENOG4107RUE	extracellular solute-binding protein family 1
EWH46_09540	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_09545	ENOG4105F38	ABC transporter, permease
EWH46_09550	ENOG4105D38	putrescine abc transporter
EWH46_09555	ENOG4108PCN	EamA-like transporter family
EWH46_09560	ENOG4105K56	Transcriptional regulator
EWH46_09565	ENOG4108ZHJ	Organic hydroperoxide resistance protein
EWH46_09575	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
EWH46_09585	ENOG4105CHR	reductase
EWH46_09590	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_09595	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
EWH46_09605	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
EWH46_09620	ENOG4108JJA	ABC, transporter
EWH46_09685	ENOG4105CUZ	uba thif-type nad fad binding protein
EWH46_09695	ENOG4105KCK	Peptidoglycan-associated lipoprotein
EWH46_09700	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
EWH46_09740	ENOG4105C03	ribonuclease
EWH46_09745	ENOG4108Z03	MAF-like protein
EWH46_09750	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
EWH46_09755	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
EWH46_09760	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
EWH46_09765	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
EWH46_09770	ENOG4105C12	Phosphoribosylglycinamide synthetase
EWH46_09775	ENOG4105DIJ	Phosphoethanolamine transferase
EWH46_09780	ENOG4105CDY	transcriptional regulatory protein
EWH46_09790	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
EWH46_09810	ENOG4108HRK	Histidine kinase
EWH46_09815	ENOG4108VAC	response regulator
EWH46_09820	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EWH46_09835	ENOG4105VT2	5-hydroxyisourate hydrolase
EWH46_09845	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
EWH46_09865	ENOG4108R6K	riboflavin synthase, subunit alpha
EWH46_09880	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
EWH46_09890	ENOG41060WC	Enoyl-CoA hydratase
EWH46_09895	ENOG4107QX3	carboxylase
EWH46_09900	ENOG4105C1G	acyl-Coa dehydrogenase
EWH46_09905	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_09915	ENOG4105CK2	sodium dicarboxylate symporter
EWH46_09945	ENOG4108ZZF	transport protein (ExbD)
EWH46_09950	ENOG4105SG9	biopolymer transport protein, ExbD
EWH46_09960	ENOG4108JQ5	ABC transporter
EWH46_09965	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
EWH46_09985	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
EWH46_09990	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
EWH46_09995	ENOG4105D05	Receptor
EWH46_10005	ENOG4105EVD	ribosomal RNA large subunit methyltransferase N
EWH46_10015	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
EWH46_10020	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
EWH46_10050	ENOG41062QD	Membrane
EWH46_10055	ENOG4107QN1	sodium solute
EWH46_10060	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
EWH46_10075	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
EWH46_10080	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EWH46_10085	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
EWH46_10095	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
EWH46_10100	ENOG4105CKW	Inner membrane protein yedI
EWH46_10110	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EWH46_10120	ENOG4105CX6	glutaminyL-tRNA synthetase
EWH46_10125	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
EWH46_10135	ENOG4105DHQ	Histidine kinase
EWH46_10160	ENOG4105CHC	glucokinase (EC 2.7.1.2)
EWH46_10175	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
EWH46_10185	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
EWH46_10190	ENOG4105CHM	Aminotransferase
EWH46_10195	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
EWH46_10200	ENOG4105CZX	twitching motility protein
EWH46_10205	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
EWH46_10210	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
EWH46_10215	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_10235	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
EWH46_10240	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
EWH46_10245	ENOG4105FE9	pseudouridine synthase
EWH46_10250	ENOG4108IG5	Transcriptional regulator
EWH46_10255	ENOG4108ETH	Formylglycinamide ribotide synthetase
EWH46_10260	ENOG4105D5U	fad dependent oxidoreductase
EWH46_10265	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
EWH46_10270	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
EWH46_10285	ENOG4105FR1	rard protein
EWH46_10305	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_10325	ENOG4107QS8	(LipO)protein
EWH46_10345	ENOG4105F04	LysR family Transcriptional regulator
EWH46_10350	ENOG4105C7F	AcnD-accessory protein PrpF
EWH46_10360	ENOG4106P55	Transcriptional regulator
EWH46_10370	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
EWH46_10375	ENOG41079YP	Citrate utilization protein b
EWH46_10380	ENOG4105CQ0	ABC transporter
EWH46_10385	ENOG4105F0N	pyrophosphate phospho-hydrolase
EWH46_10395	ENOG4108R3D	Electron transport complex
EWH46_10510	ENOG4105DPX	Hydrogenase, large subunit
EWH46_10515	ENOG4105BZU	Histidine kinase
EWH46_10625	ENOG4105DVT	helicase
EWH46_10640	ENOG4105E3S	small subunit
EWH46_10655	ENOG4105C10	Electron transfer flavoprotein
EWH46_10660	ENOG4105BZJ	Electron transfer flavoprotein
EWH46_10670	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
EWH46_10675	ENOG4105C1G	acyl-Coa dehydrogenase
EWH46_10680	ENOG4105X7H	acyl-CoA dehydrogenase
EWH46_10685	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_10690	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
EWH46_10695	ENOG4107V2S	Transcriptional regulator
EWH46_10705	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
EWH46_10710	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWH46_10715	ENOG4105C5W	Aldolase
EWH46_10720	ENOG4106KED	esterase YpfH
EWH46_10730	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EWH46_10740	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_10745	ENOG4108V3W	Chemotaxis protein, CheW
EWH46_10750	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
EWH46_10755	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
EWH46_10760	ENOG4108V3W	Chemotaxis protein, CheW
EWH46_10775	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
EWH46_10780	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
EWH46_10785	ENOG4107S2Z	UPF0761 membrane protein
EWH46_10795	ENOG4105CQB	FAD linked oxidase domain protein
EWH46_10815	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EWH46_10820	ENOG4105C8S	subunit m
EWH46_10830	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EWH46_10835	ENOG4105DF2	NADH dehydrogenase subunit j
EWH46_10840	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EWH46_10845	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
EWH46_10850	ENOG4108IEH	NADH dehydrogenase subunit g
EWH46_10860	ENOG4105GKE	subunit e
EWH46_10865	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EWH46_10870	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EWH46_10875	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
EWH46_10880	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EWH46_10895	ENOG4105CP7	Triose-phosphate isomerase
EWH46_10905	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
EWH46_10910	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
EWH46_10915	ENOG4105CHM	Aminotransferase
EWH46_10920	ENOG4105ES9	amino acid
EWH46_10925	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EWH46_10930	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
EWH46_10940	ENOG4105W2Z	cytochrome C, class I
EWH46_10950	ENOG4108TEB	UPF0114 protein
EWH46_10970	ENOG4105BZU	Histidine kinase
EWH46_10975	ENOG4108VAU	general secretion pathway protein G
EWH46_10980	ENOG4105BZU	Histidine kinase
EWH46_10985	ENOG4105BZU	Histidine kinase
EWH46_10990	ENOG4105D8X	mechanosensitive ion channel
EWH46_10995	ENOG4105D3G	Pseudouridine synthase
EWH46_11005	ENOG4105D7W	serine acetyltransferase
EWH46_11040	ENOG4105C1J	atp-dependent rna helicase
EWH46_11045	ENOG4105EB3	Histidine kinase
EWH46_11050	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EWH46_11060	ENOG4105BZS	acriflavin resistance protein
EWH46_11065	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
EWH46_11080	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EWH46_11100	ENOG4108NEV	two component transcriptional regulator, LytTR family
EWH46_11105	ENOG4108HRK	Histidine kinase
EWH46_11110	ENOG4105CH7	arginosuccinase
EWH46_11115	ENOG4105PI0	Ferredoxin
EWH46_11125	ENOG4108MEJ	flavin reductase domain protein
EWH46_11130	ENOG4105EN6	Membrane
EWH46_11135	ENOG4105NSG	hemerythrin hhe cation binding domain protein
EWH46_11150	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EWH46_11155	ENOG4106855	Competence protein
EWH46_11190	ENOG4105CFU	surface antigen
EWH46_11245	ENOG4105C4R	Atp-dependent dna helicase
EWH46_11265	ENOG4105KHS	type IV fimbrial pilin protein
EWH46_11315	ENOG4105CFP	Peptidase U32
EWH46_11335	ENOG4105E7W	lamb ycsf family protein
EWH46_11345	ENOG4105P4J	Allophanate hydrolase, subunit 1
EWH46_11350	ENOG4107QIJ	Aconitate hydratase 2
EWH46_11365	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
EWH46_11370	ENOG4105FDP	GntR family transcriptional regulator
EWH46_11390	ENOG4105E33	succinate dehydrogenase
EWH46_11395	ENOG41060IS	Flavinator of succinate dehydrogenase
EWH46_11400	ENOG4105BZN	citrate synthase
EWH46_11410	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_11415	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EWH46_11425	ENOG4105FZW	flagellar biosynthesis regulator FlhF
EWH46_11430	ENOG4105D7B	Flagellar biosynthesis protein flha
EWH46_11435	ENOG4105D00	flagellar biosynthetic protein flhB
EWH46_11445	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
EWH46_11460	ENOG4105DFW	ABC transporter
EWH46_11470	ENOG4108HWW	ABC transporter
EWH46_11480	ENOG4106RE7	Cytochrome
EWH46_11485	ENOG4105C5Q	Transcriptional regulator
EWH46_11495	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
EWH46_11500	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
EWH46_11505	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
EWH46_11510	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
EWH46_11515	ENOG4105K59	histidine triad (HIT) protein
EWH46_11525	ENOG4107Z6S	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
EWH46_11530	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
EWH46_11535	ENOG4105C0H	protease
EWH46_11540	ENOG4107QNR	UPF0135 protein
EWH46_11550	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
EWH46_11555	ENOG4105CV6	ABC transporter, permease
EWH46_11575	ENOG4105D9P	serine threonine protein kinase
EWH46_11580	ENOG4108IFG	nitrite reductase, (NAD(P)H)
EWH46_11590	ENOG4108MTB	glycosyl transferase family
EWH46_11605	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
EWH46_11610	ENOG4106A3M	Cytochrome p-450
EWH46_11615	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
EWH46_11625	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
EWH46_11630	ENOG4107QX3	carboxylase
EWH46_11635	ENOG4105DJT	lAO AO transport system ATPase
EWH46_11650	ENOG4105DRR	Transcriptional regulator, GntR family
EWH46_11655	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
EWH46_11660	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
EWH46_11675	ENOG4108V1U	phospholipid-binding protein
EWH46_11705	ENOG4107QN2	dihydrolipoyl dehydrogenase
EWH46_11710	ENOG4107QSN	dihydrolipoamide acetyltransferase
EWH46_11715	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
EWH46_11720	ENOG4105BZU	Histidine kinase
EWH46_11725	ENOG4108ZXC	Two component transcriptional regulator, luxr family
EWH46_11730	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
EWH46_11740	ENOG4105DGW	oligopeptidase A
EWH46_11750	ENOG4107RA4	Glycosyl transferase (Group 1
EWH46_11765	ENOG4105BZU	Histidine kinase
EWH46_11780	ENOG41082RQ	UPF0102 protein
EWH46_11785	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
EWH46_11790	ENOG4105W4M	Transport-associated protein
EWH46_11795	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
EWH46_11800	ENOG4105CZX	twitching motility protein
EWH46_11805	ENOG4105CZX	twitching motility protein
EWH46_11810	ENOG4105DFA	alanine racemase domain protein
EWH46_11820	ENOG4105EW9	transcriptional regulator AsnC family
EWH46_11825	ENOG4105C26	Dehydrogenase
EWH46_11840	ENOG4105II7	pyrroline-5-carboxylate reductase
EWH46_11880	ENOG4105DUM	transcriptional regulator, lysR family
EWH46_11890	ENOG4105D82	Glutamate dehydrogenase
EWH46_11910	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
EWH46_11920	ENOG4105CJB	Exodeoxyribonuclease I
EWH46_11925	ENOG4107QIM	DNA ligase
EWH46_11940	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
EWH46_11945	ENOG4105CD8	aminopeptidase N
EWH46_11950	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EWH46_11965	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
EWH46_11970	ENOG4105CA0	peroxidase
EWH46_11975	ENOG4105CA0	peroxidase
EWH46_11980	ENOG4107QYX	exodeoxyribonuclease v alpha
EWH46_11985	ENOG4107QKA	exodeoxyribonuclease V beta
EWH46_11990	ENOG4105DSY	exodeoxyribonuclease V, gamma
EWH46_12000	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
EWH46_12015	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
EWH46_12030	ENOG4105BZU	Histidine kinase
EWH46_12050	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
EWH46_12080	ENOG4108SHN	Glycosyl transferase, family 2
EWH46_12085	ENOG4105CPK	Glycosyl transferase (Group 1
EWH46_12140	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
EWH46_12145	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
EWH46_12150	ENOG4105EXC	Acyl-transferase
EWH46_12160	ENOG4108IAJ	Nad-dependent epimerase dehydratase
EWH46_12165	ENOG4105D3Q	Sugar transferase
EWH46_12170	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
EWH46_12175	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
EWH46_12180	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
EWH46_12195	ENOG41090RK	glycosyl transferase
EWH46_12220	ENOG4107SBE	Glycosyl transferase (Group 1
EWH46_12235	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
EWH46_12240	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
EWH46_12250	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
EWH46_12255	ENOG4105C30	Nad-dependent epimerase dehydratase
EWH46_12270	ENOG4105D75	Capsular exopolysaccharide family
EWH46_12275	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
EWH46_12290	ENOG4105D7V	transposase
EWH46_12300	ENOG4105C1J	atp-dependent rna helicase
EWH46_12315	ENOG4105D1Q	UPF0246 protein
EWH46_12330	ENOG4105CSM	endonuclease III
EWH46_12335	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
EWH46_12340	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
EWH46_12350	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
EWH46_12355	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
EWH46_12365	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
EWH46_12370	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
EWH46_12375	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
EWH46_12380	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EWH46_12385	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
EWH46_12390	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
EWH46_12395	ENOG4105E0A	ABC, transporter
EWH46_12400	ENOG4105EHG	Permease protein
EWH46_12405	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
EWH46_12410	ENOG4108YZT	Adenosylcobinamide kinase
EWH46_12415	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
EWH46_12430	ENOG4105HF0	Membrane
EWH46_12435	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_12440	ENOG4105CBS	Chea signal transduction histidine kinase
EWH46_12445	ENOG4108VYJ	response regulator receiver protein
EWH46_12450	ENOG4105BZU	Histidine kinase
EWH46_12470	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
EWH46_12480	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
EWH46_12485	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
EWH46_12490	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
EWH46_12495	ENOG4105CIH	Imidazole acetol-phosphate transaminase
EWH46_12500	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
EWH46_12505	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
EWH46_12510	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
EWH46_12520	ENOG4105E3A	(ABC) transporter
EWH46_12525	ENOG4105DA5	(ABC) transporter
EWH46_12530	ENOG4105CYM	Glutathione S-transferase
EWH46_12540	ENOG4109066	lysm domain bon superfamily protein
EWH46_12565	ENOG4105DNZ	Alpha Beta Hydrolase
EWH46_12580	ENOG4105XA0	heptosyltransferase ii
EWH46_12590	ENOG4105CM2	brancheD-chain amino acid aminotransferase
EWH46_12595	ENOG4105BZU	Histidine kinase
EWH46_12615	ENOG4107QZ7	Cellulose synthase catalytic subunit
EWH46_12620	ENOG4107EEX	Cellulose synthase regulator protein
EWH46_12625	ENOG4105K2Z	endo-1,4-d-glucanase (EC 3.2.1.4)
EWH46_12630	ENOG4105EJG	cellulose synthase
EWH46_12640	ENOG4105D9R	oxidoreductase
EWH46_12655	ENOG4105CG3	alpha amylase, catalytic region
EWH46_12665	ENOG4105CG3	alpha amylase, catalytic region
EWH46_12680	ENOG4107T3P	ABC, transporter
EWH46_12690	ENOG4105F4R	Transcriptional regulator mode
EWH46_12695	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
EWH46_12700	ENOG4105E0C	molybdate abc transporter
EWH46_12705	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
EWH46_12735	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
EWH46_12745	ENOG4105W8I	Transcriptional regulator
EWH46_12750	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_12755	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_12765	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
EWH46_12770	ENOG4105C26	Dehydrogenase
EWH46_12775	ENOG4105EXG	Transcriptional regulator
EWH46_12780	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
EWH46_12785	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
EWH46_12790	ENOG4105DGI	Alkaline phosphatase
EWH46_12810	ENOG4108WBT	adenosyltransferase
EWH46_12820	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
EWH46_12825	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
EWH46_12830	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
EWH46_12835	ENOG4105WD1	Membrane
EWH46_12845	ENOG4105KB2	stringent starvation protein b
EWH46_12850	ENOG4107MKT	Stringent starvation protein a
EWH46_12855	ENOG4105EIX	cytochrome c1
EWH46_12860	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EWH46_12865	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
EWH46_12870	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
EWH46_12875	ENOG4105BZU	Histidine kinase
EWH46_12880	ENOG4105CGF	Aromatic amino acid aminotransferase
EWH46_12895	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
EWH46_12915	ENOG410829K	Lysine exporter protein (Lyse ygga)
EWH46_12920	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
EWH46_12930	ENOG4105BZU	Histidine kinase
EWH46_12940	ENOG4105NBK	UPF0345 protein
EWH46_12945	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_12955	ENOG4105D9P	serine threonine protein kinase
EWH46_12980	ENOG4105DBV	ornithine carbamoyltransferase
EWH46_12985	ENOG4105C8Y	Acetylornithine aminotransferase
EWH46_13040	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
EWH46_13045	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
EWH46_13060	ENOG4105WJ3	XRE family Transcriptional regulator
EWH46_13075	ENOG41067B5	Histone deacetylase superfamily protein
EWH46_13080	ENOG4108IV0	ABC, transporter
EWH46_13085	ENOG4105C0Z	ABC transporter
EWH46_13090	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
EWH46_13095	ENOG4105C32	Amino acid ABC transporter (Permease)
EWH46_13100	ENOG4105D1H	recombination factor protein RarA
EWH46_13105	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
EWH46_13120	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
EWH46_13125	ENOG4105C3M	thioredoxin reductase
EWH46_13130	ENOG4105KDC	50s ribosomal protein l28
EWH46_13135	ENOG4105W0E	50S ribosomal protein L33
EWH46_13150	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
EWH46_13155	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
EWH46_13160	ENOG4105VP5	Bacterial protein of unknown function (DUF937)
EWH46_13170	ENOG4105E0F	Histidine kinase
EWH46_13195	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
EWH46_13200	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
EWH46_13205	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
EWH46_13210	ENOG4105DSJ	YicC domain protein
EWH46_13225	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
EWH46_13230	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
EWH46_13235	ENOG4105CSA	Coproporphyrinogen iii oxidase
EWH46_13240	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EWH46_13245	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
EWH46_13250	ENOG4105BZU	Histidine kinase
EWH46_13265	ENOG4108DG9	Smr protein MutS2
EWH46_13270	ENOG4105W5Q	DNA repair protein (RadC
EWH46_13275	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
EWH46_13280	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
EWH46_13285	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
EWH46_13345	ENOG4107QMH	DNA methylase
EWH46_13355	ENOG4105C0D	helicase
EWH46_13395	ENOG4107RZZ	dna polymerase iii epsilon subunit
EWH46_13400	ENOG4108ZIT	Ferredoxin, 2FE-2S
EWH46_13405	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
EWH46_13410	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
EWH46_13420	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
EWH46_13425	ENOG4105C3J	Cysteine desulfurase
EWH46_13430	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
EWH46_13440	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
EWH46_13445	ENOG4105CGF	Aromatic amino acid aminotransferase
EWH46_13475	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
EWH46_13485	ENOG41080Z8	PHOSPHOCARRIER protein
EWH46_13500	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
EWH46_13505	ENOG4105VS8	Flagellar biosynthetic protein fliq
EWH46_13510	ENOG4105CN7	Flagellar biosynthetic protein FliP
EWH46_13520	ENOG4105DD5	Flagellar motor switch protein
EWH46_13525	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
EWH46_13545	ENOG4108JIR	Flagellum-specific ATP synthase
EWH46_13550	ENOG4105W2B	Flagellar assembly protein
EWH46_13555	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
EWH46_13560	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
EWH46_13565	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
EWH46_13570	ENOG4108REP	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity)
EWH46_13580	ENOG4105MQ3	flagellar protein FliS
EWH46_13590	ENOG4105DTS	flagellar hook-associated
EWH46_13595	ENOG4105I03	Flagellin
EWH46_13595	ENOG4105I03	Flagellin
EWH46_13610	ENOG4105GEH	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity)
EWH46_13615	ENOG4106CIA	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region
EWH46_13635	ENOG4107RD7	Flagellar Motor Protein, MotA
EWH46_13640	ENOG4105ER2	Ompa motb domain protein
EWH46_13645	ENOG4108VYJ	response regulator receiver protein
EWH46_13650	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
EWH46_13665	ENOG4108J2R	molybdopterin oxidoreductase
EWH46_13670	ENOG4105CH2	amidohydrolase
EWH46_13685	ENOG4107QP8	phosphohexose isomerase
EWH46_13690	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EWH46_13700	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
EWH46_13705	ENOG4105CHC	glucokinase (EC 2.7.1.2)
EWH46_13725	ENOG4107PE3	Mammalian cell entry related domain protein
EWH46_13730	ENOG4105CY3	ABC transporter, permease
EWH46_13735	ENOG4105DHJ	ABC, transporter
EWH46_13740	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
EWH46_13795	ENOG4105D49	3-dehydroquinate synthase
EWH46_13800	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
EWH46_13810	ENOG4105E4G	Type IV pilus
EWH46_13835	ENOG4108JQC	penicillin-binding protein 1A
EWH46_13840	ENOG4105XQ6	frataxin-like protein
EWH46_13860	ENOG4108Z9W	Outer membrane porin
EWH46_13865	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
EWH46_13880	ENOG4108UKZ	OsmC family
EWH46_13885	ENOG4105C7B	Threonine dehydratase
EWH46_13890	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
EWH46_13900	ENOG4108VAU	general secretion pathway protein G
EWH46_13905	ENOG41069X0	general secretion pathway protein h
EWH46_13910	ENOG4105X5Z	General secretion pathway protein I
EWH46_13915	ENOG4108WWZ	General secretion pathway protein J
EWH46_13940	ENOG4105GVR	general secretion pathway protein D
EWH46_13945	ENOG4107QHF	type ii secretion system protein e
EWH46_13950	ENOG4105D7Q	type ii secretion system
EWH46_13955	ENOG4105BZU	Histidine kinase
EWH46_13960	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EWH46_13970	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
EWH46_13980	ENOG4105C0Z	ABC transporter
EWH46_14000	ENOG4108IV0	ABC, transporter
EWH46_14005	ENOG4105DZS	Phenylacetate-CoA ligase
EWH46_14015	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
EWH46_14020	ENOG4108K5P	(LipO)protein
EWH46_14025	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
EWH46_14030	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
EWH46_14045	ENOG4108UJD	30S ribosomal protein S9
EWH46_14050	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
EWH46_14060	ENOG410600T	transposase
EWH46_14085	ENOG4105UIB	(ABC) transporter
EWH46_14090	ENOG4108JQ9	ABC transporter
EWH46_14095	ENOG4107QUY	Guanine deaminase
EWH46_14110	ENOG4105C7W	Xanthine dehydrogenase
EWH46_14120	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
EWH46_14125	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
EWH46_14130	ENOG4105ESV	Glycosyl transferase, family 4
EWH46_14145	ENOG4107RJ7	Glycosyl transferase (Group 1
EWH46_14175	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
EWH46_14180	ENOG4105C30	Nad-dependent epimerase dehydratase
EWH46_14195	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
EWH46_14200	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
EWH46_14205	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
EWH46_14210	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
EWH46_14220	ENOG4105C1J	atp-dependent rna helicase
EWH46_14225	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
EWH46_14230	ENOG4108UHJ	MAF-like protein
EWH46_14240	ENOG4105VGS	50s ribosomal protein l32
EWH46_14245	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
EWH46_14250	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
EWH46_14255	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
EWH46_14260	ENOG4105CHR	reductase
EWH46_14265	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
EWH46_14270	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
EWH46_14280	ENOG4105EMN	RNA polymerase sigma factor
EWH46_14295	ENOG4105C0H	protease
EWH46_14300	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
EWH46_14305	ENOG4105C3F	Signal peptidase i
EWH46_14315	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
EWH46_14320	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
EWH46_14325	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
EWH46_14330	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
EWH46_14335	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
EWH46_14340	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
EWH46_14355	ENOG4105C03	ribonuclease
EWH46_14360	ENOG4105EI2	Pseudouridine synthase
EWH46_14375	ENOG4108E8C	) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
EWH46_14380	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
EWH46_14385	ENOG4105RQF	LysR family Transcriptional regulator
EWH46_14390	ENOG4108UQY	Iron-storage protein
EWH46_14400	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
EWH46_14410	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_14420	ENOG4105ETT	transcriptional Regulator, LysR family
EWH46_14435	ENOG4107TVC	Glycosyl transferase, family 2
EWH46_14450	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
EWH46_14455	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
EWH46_14460	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
EWH46_14465	ENOG4105M6F	mutator MutT protein
EWH46_14475	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
EWH46_14485	ENOG4105CAS	nag kinase
EWH46_14505	ENOG4107R16	Multicopper oxidase
EWH46_14535	ENOG4107QN1	sodium solute
EWH46_14540	ENOG41062QD	Membrane
EWH46_14545	ENOG4105CTD	carboxy-peptidase
EWH46_14555	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EWH46_14560	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
EWH46_14580	ENOG4105QAX	Iron-sulfur
EWH46_14585	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EWH46_14615	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
EWH46_14625	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
EWH46_14630	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
EWH46_14635	ENOG4105DC1	bifunctional purine biosynthesis protein purh
EWH46_14640	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
EWH46_14650	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
EWH46_14670	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
EWH46_14675	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
EWH46_14680	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
EWH46_14685	ENOG4105BZU	Histidine kinase
EWH46_14700	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
EWH46_14705	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
EWH46_14710	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
EWH46_14715	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
EWH46_14720	ENOG4105CPF	Cell wall formation (By similarity)
EWH46_14725	ENOG4105DFU	Cell wall formation (By similarity)
EWH46_14730	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
EWH46_14745	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
EWH46_14750	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
EWH46_14755	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
EWH46_14760	ENOG4105CJN	penicillin-binding protein
EWH46_14770	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
EWH46_14780	ENOG4105R8A	Heat shock protein
EWH46_14790	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
EWH46_14795	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EWH46_14800	ENOG4105DFF	Rod shape-determining protein mreb
EWH46_14805	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
EWH46_14815	ENOG4105CJN	penicillin-binding protein
EWH46_14820	ENOG4105CNI	cell division protein FtsW
EWH46_14825	ENOG4105DHQ	Histidine kinase
EWH46_14835	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
EWH46_14840	ENOG4108004	Modulates RecA activity (By similarity)
EWH46_14845	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
EWH46_14850	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
EWH46_14855	ENOG4105DU1	integral membrane protein, terc
EWH46_14860	ENOG41086DT	Membrane protein of unknown function
EWH46_14865	ENOG4105ERG	peptidase m48, ste24p
EWH46_14870	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
EWH46_14875	ENOG4108YSG	O-Antigen polymerase
EWH46_14885	ENOG4105KHS	type IV fimbrial pilin protein
EWH46_14890	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
EWH46_14895	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
EWH46_14925	ENOG4105CSU	acyl-Coa dehydrogenase
EWH46_14940	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_14945	ENOG4105CGU	Enoyl-CoA hydratase
EWH46_14955	ENOG4105NAU	thioesterase Superfamily protein
EWH46_14960	ENOG4108JJ7	ABC transporter
EWH46_14970	ENOG4107YNJ	LysR family Transcriptional regulator
EWH46_14975	ENOG4105EKE	dihydroorotase
EWH46_14980	ENOG4105D0M	Protease HtpX homolog
EWH46_14985	ENOG4105DZQ	phospholipase D Transphosphatidylase
EWH46_14995	ENOG4108TIT	dATP pyrophosphohydrolase
EWH46_15010	ENOG4105C9M	aspartyl-trna synthetase
EWH46_15025	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
EWH46_15035	ENOG4105CMR	udp-glucose 4-epimerase
EWH46_15050	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
EWH46_15055	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
EWH46_15070	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
EWH46_15080	ENOG4105ES5	Histidine kinase
EWH46_15110	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
EWH46_15115	ENOG4105D64	Mechanosensitive ion channel
EWH46_15120	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_15140	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
EWH46_15165	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
EWH46_15170	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
EWH46_15175	ENOG4105C6F	GntR Family Transcriptional Regulator
EWH46_15190	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
EWH46_15195	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
EWH46_15200	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
EWH46_15205	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
EWH46_15210	ENOG4105MJ2	Competence protein
EWH46_15215	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
EWH46_15220	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
EWH46_15230	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
EWH46_15240	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
EWH46_15260	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
EWH46_15265	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
EWH46_15270	ENOG4108ZX6	Electron transport protein SCO1 SenC
EWH46_15275	ENOG4105D2N	Aldolase
EWH46_15280	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
EWH46_15285	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
EWH46_15290	ENOG4105CV1	Transketolase (EC 2.2.1.1)
EWH46_15295	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
EWH46_15300	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EWH46_15305	ENOG4106F1P	AAA ATPase, central domain protein
EWH46_15310	ENOG4108VFZ	ribulose bisphosphate carboxylase, small
EWH46_15315	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
EWH46_15320	ENOG4105DUM	transcriptional regulator, lysR family
EWH46_15325	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_15345	ENOG4107V1M	polysaccharide export protein
EWH46_15355	ENOG4105C2X	Arabinose 5-phosphate isomerase
EWH46_15365	ENOG41084CK	capsule polysaccharide
EWH46_15370	ENOG4105DMF	Dehydrogenase
EWH46_15375	ENOG4105DMF	Dehydrogenase
EWH46_15380	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
EWH46_15385	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
EWH46_15390	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
EWH46_15395	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
EWH46_15400	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
EWH46_15410	ENOG4105F27	Major Facilitator
EWH46_15435	ENOG4105BZU	Histidine kinase
EWH46_15450	ENOG4108ZT0	50S ribosomal protein l17
EWH46_15455	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
EWH46_15460	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
EWH46_15465	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
EWH46_15470	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EWH46_15475	ENOG41067V7	50S ribosomal protein L36
EWH46_15485	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
EWH46_15490	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
EWH46_15495	ENOG4105VPB	50S ribosomal protein L30
EWH46_15500	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
EWH46_15505	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
EWH46_15510	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
EWH46_15515	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
EWH46_15520	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
EWH46_15525	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EWH46_15530	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
EWH46_15535	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
EWH46_15545	ENOG4105BZU	Histidine kinase
EWH46_15550	ENOG4108YZA	Nitrogen regulatory protein pii
EWH46_15555	ENOG4105C0P	Mg chelatase subunit ChlI
EWH46_15560	ENOG4107Z67	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
EWH46_15565	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
EWH46_15575	ENOG4105DH7	May be involved in recombination (By similarity)
EWH46_15580	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
EWH46_15585	ENOG41061CK	Antibiotic biosynthesis monooxygenase
EWH46_15590	ENOG4108VWS	Yaeq family
EWH46_15595	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
EWH46_15605	ENOG4107QM2	Aldo Keto reductase
EWH46_15610	ENOG4105BZU	Histidine kinase
EWH46_15620	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
EWH46_15645	ENOG4105C5X	domain protein
EWH46_15655	ENOG4105IJJ	transcriptional regulator, crp fnr family
EWH46_15660	ENOG4105ERG	peptidase m48, ste24p
EWH46_15665	ENOG4105EYM	Major Facilitator superfamily
EWH46_15675	ENOG4105K63	Thioredoxin
EWH46_15690	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_15695	ENOG4107S45	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EWH46_15710	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
EWH46_15715	ENOG4105FFC	UPF0187 protein
EWH46_15720	ENOG4108JQB	penicillin-binding protein 1C
EWH46_15740	ENOG4105BZU	Histidine kinase
EWH46_15745	ENOG4105BZU	Histidine kinase
EWH46_15750	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
EWH46_15755	ENOG4105WF7	pyrroloquinoline quinone biosynthesis protein d
EWH46_15765	ENOG4105JIE	May be involved in the transport of PQQ or its precursor to the periplasm (By similarity)
EWH46_15770	ENOG4105BZU	Histidine kinase
EWH46_15795	ENOG4108IRC	dna polymerase iii
EWH46_15800	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
EWH46_15805	ENOG4105BZU	Histidine kinase
EWH46_15820	ENOG4107QN1	sodium solute
EWH46_15840	ENOG4105C9U	ATP-dependent DNA helicase RecQ
EWH46_15850	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
EWH46_15860	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
EWH46_15865	ENOG4105CV1	Transketolase (EC 2.2.1.1)
EWH46_15905	ENOG4108S0S	Nucleotidyl transferase
EWH46_15910	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
EWH46_15915	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
EWH46_15920	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
EWH46_15925	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
EWH46_15935	ENOG4105DXI	Major Facilitator superfamily
EWH46_15940	ENOG4105EA8	2-Nitropropane dioxygenase
EWH46_15945	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
EWH46_15955	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_15965	ENOG4105F38	ABC transporter, permease
EWH46_15970	ENOG4105EG2	ABC transporter, permease
EWH46_15975	ENOG4108PVQ	transcriptional regulator
EWH46_15985	ENOG4105CQB	FAD linked oxidase domain protein
EWH46_15990	ENOG4105ED1	spovr family
EWH46_15995	ENOG4106AKX	UPF0229 protein
EWH46_16000	ENOG4105CYN	Serine protein kinase
EWH46_16015	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
EWH46_16035	ENOG4105D9P	serine threonine protein kinase
EWH46_16040	ENOG4108ZF3	Phosphatase
EWH46_16050	ENOG4107YM4	Beta-lactamase domain-containing protein
EWH46_16055	ENOG4105EJ9	Membrane
EWH46_16060	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
EWH46_16065	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
EWH46_16070	ENOG4105VFU	Rna-binding protein
EWH46_16075	ENOG4105EMU	Dehydrogenase
EWH46_16085	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
EWH46_16090	ENOG4105C2X	Arabinose 5-phosphate isomerase
EWH46_16105	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
EWH46_16110	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
EWH46_16115	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
EWH46_16125	ENOG4105VG0	50S ribosomal protein l34
EWH46_16130	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
EWH46_16135	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
EWH46_16140	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
EWH46_16145	ENOG41062MS	nucleotidyltransferase substrate binding protein
EWH46_16150	ENOG41060A7	DNA polymerase beta domain protein region
EWH46_16160	ENOG4105C4R	Atp-dependent dna helicase
EWH46_16185	ENOG4105FD8	phosphonate metabolism protein PhnM
EWH46_16200	ENOG4105CBD	Diacylglycerol kinase
EWH46_16205	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
EWH46_16210	ENOG4105E2V	Glycosyltransferase 36
EWH46_16235	ENOG4105WH1	Two component transcriptional regulator luxr family
EWH46_16240	ENOG4105D7Z	glutathione synthase
EWH46_16245	ENOG4105DKK	Benzoate
EWH46_16250	ENOG4105EHM	Aminoglycoside phosphotransferase
EWH46_16255	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
EWH46_16260	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
EWH46_16265	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
EWH46_16285	ENOG4105C6K	Malic enzyme
EWH46_16290	ENOG4105BZU	Histidine kinase
EWH46_16295	ENOG4108ZXC	Two component transcriptional regulator, luxr family
EWH46_16300	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
EWH46_16305	ENOG4108ZAI	phosphatidylglycerophosphatase a
EWH46_16310	ENOG4107TH8	cina domain protein
EWH46_16315	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
EWH46_16320	ENOG4105BZU	Histidine kinase
EWH46_16340	ENOG4105C8T	Leucyl-tRNA synthetase
EWH46_16345	ENOG4105M8F	Biopolymer transport protein exbD tolR
EWH46_16360	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
EWH46_16365	ENOG41090R7	Ferric uptake
EWH46_16370	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
EWH46_16375	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
EWH46_16380	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
EWH46_16385	ENOG4107QUT	magnesium and cobalt transport protein CorA
EWH46_16395	ENOG4105EMU	Dehydrogenase
EWH46_16415	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
EWH46_16435	ENOG4108XDN	Transcriptional regulator
EWH46_16440	ENOG4105DS1	cytochrome b561
EWH46_16460	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
EWH46_16470	ENOG4105DY2	Paraquat-inducible protein b
EWH46_16475	ENOG4105DHJ	ABC, transporter
EWH46_16480	ENOG4105CY3	ABC transporter, permease
EWH46_16500	ENOG4105K3G	Periplasmic Protein
EWH46_16505	ENOG4107S2Z	UPF0761 membrane protein
EWH46_16525	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
EWH46_16530	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
EWH46_16550	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
EWH46_16555	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
EWH46_16565	ENOG4105CRE	cytochrome C
EWH46_16575	ENOG4106RE7	Cytochrome
EWH46_16580	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
EWH46_16585	ENOG4105ETE	Transcriptional regulator (LacI family
EWH46_16590	ENOG4105D78	K07001 NTE family protein
EWH46_16605	ENOG4105P52	geranylgeranyl reductase
EWH46_16610	ENOG4105BZU	Histidine kinase
EWH46_16620	ENOG4105E7A	Glutamine amidotransferase
EWH46_16635	ENOG4108JQ6	ABC transporter
EWH46_16645	ENOG4108RVA	ribokinase
EWH46_16665	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
EWH46_16675	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
EWH46_16680	ENOG4107TUY	Histidine kinase
EWH46_16695	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EWH46_16705	ENOG4105D52	delta-aminolevulinic acid dehydratase
EWH46_16710	ENOG4105D7N	magnesium and cobalt transport protein CorA
EWH46_16715	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
EWH46_16725	ENOG41072GX	Peptidase M22 Glycoprotease
EWH46_16735	ENOG4105W3H	MtN3 and saliva related transmembrane protein
EWH46_16745	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
EWH46_16750	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
EWH46_16755	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
EWH46_16770	ENOG4105C8V	SAICAR synthetase
EWH46_16775	ENOG4105D2N	Aldolase
EWH46_16780	ENOG4105CA9	Pyruvate kinase
EWH46_16785	ENOG4105C6K	Malic enzyme
EWH46_16790	ENOG4105BZA	Phosphoglycerate kinase
EWH46_16810	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
EWH46_16815	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
EWH46_16825	ENOG4105C79	DNA protecting protein DprA
EWH46_16830	ENOG4108RPN	Protein smg homolog
EWH46_16840	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EWH46_16845	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
EWH46_16850	ENOG4105VIE	preprotein translocase, subunit YajC
EWH46_16855	ENOG4105BZU	Histidine kinase
EWH46_16860	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
EWH46_16865	ENOG4105C4R	Atp-dependent dna helicase
EWH46_16870	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
EWH46_16885	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
EWH46_16890	ENOG4108JJB	ABC transporter
EWH46_16900	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
EWH46_16905	ENOG4105F7P	transcriptional regulator AsnC family
EWH46_16915	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
EWH46_16930	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
EWH46_16935	ENOG4105CSR	polyphosphate kinase 2
EWH46_16955	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
EWH46_16970	ENOG4105E4C	Lytic transglycosylase catalytic
EWH46_16985	ENOG4105SYT	Methylenetetrahydrofolate reductase
EWH46_16990	ENOG4105DX0	Hemolysin A
EWH46_16995	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
EWH46_17020	ENOG4108Z43	UPF0250 protein
EWH46_17025	ENOG4105DZ1	carboxypeptidase
EWH46_17030	ENOG4105DHZ	alpha beta
EWH46_17045	ENOG4108YXA	Membrane
EWH46_17050	ENOG4105D9P	serine threonine protein kinase
EWH46_17055	ENOG4105C75	arginyL-tRNA synthetase
EWH46_17075	ENOG4108IUZ	ABC transporter
EWH46_17080	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
EWH46_17110	ENOG4105FGF	GDP-mannose mannosyl hydrolase
EWH46_17120	ENOG4105D75	Capsular exopolysaccharide family
EWH46_17130	ENOG4108SHN	Glycosyl transferase, family 2
EWH46_17150	ENOG4105D75	Capsular exopolysaccharide family
EWH46_17155	ENOG4105D3Q	Sugar transferase
EWH46_17165	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_17180	ENOG4105JN3	extra-cytoplasmic solute receptor family protein
EWH46_17185	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
EWH46_17195	ENOG4105BZU	Histidine kinase
EWH46_17205	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
EWH46_17225	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
EWH46_17240	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
EWH46_17255	ENOG4105DR4	Methyltransferase
EWH46_17270	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
EWH46_17275	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_17285	ENOG4105DEI	Mannitol dehydrogenase
EWH46_17290	ENOG41075H3	AraC family transcriptional regulator
EWH46_17295	ENOG4105CMG	Carbohydrate kinase
EWH46_17310	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
EWH46_17325	ENOG4105D1S	lipid A biosynthesis
EWH46_17335	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
EWH46_17340	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_17355	ENOG4107SPG	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
EWH46_17360	ENOG4105CSR	polyphosphate kinase 2
EWH46_17365	ENOG4105EW9	transcriptional regulator AsnC family
EWH46_17375	ENOG4105CEY	Amp-dependent synthetase and ligase
EWH46_17390	ENOG4105CD5	CoA-binding domain protein
EWH46_17415	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
EWH46_17440	ENOG4105BZU	Histidine kinase
EWH46_17450	ENOG4105CGZ	zinc metallopeptidase
EWH46_17455	ENOG4105EJC	lysr family transcriptional regulator
EWH46_17480	ENOG4107QP3	malate synthase g
EWH46_17485	ENOG4105C2C	drug resistance transporter, Bcr CflA
EWH46_17500	ENOG41067RQ	csbd family
EWH46_17515	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
EWH46_17525	ENOG4108Z9W	Outer membrane porin
EWH46_17535	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
EWH46_17540	ENOG41060NJ	transcriptional regulator
EWH46_17545	ENOG4105DFW	ABC transporter
EWH46_17550	ENOG4108HWW	ABC transporter
EWH46_17560	ENOG4105CMG	Carbohydrate kinase
EWH46_17585	ENOG4107R7Y	intracellular protease Pfpi family
EWH46_17590	ENOG4105C31	Tryptophanyl-tRNA synthetase
EWH46_17600	ENOG4105DEN	Luciferase family
EWH46_17615	ENOG4105BZU	Histidine kinase
EWH46_17620	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
EWH46_17635	ENOG4108XM1	transcriptional regulator AsnC family
EWH46_17640	ENOG4107P2S	Transcriptional regulator
EWH46_17645	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
EWH46_17650	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
EWH46_17655	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EWH46_17660	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
EWH46_17670	ENOG4108Z6Z	Transcriptional regulator
EWH46_17680	ENOG4107QJE	Chromosome Partitioning Protein
EWH46_17685	ENOG4108NIW	Leucine export protein LeuE
EWH46_17690	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
EWH46_17695	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
EWH46_17710	ENOG4105KRS	Proteinase inhibitor
EWH46_17720	ENOG4105CF7	AraC family transcriptional regulator
EWH46_17725	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
EWH46_17740	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
EWH46_17745	ENOG4105J0Q	Transcriptional regulator
EWH46_17780	ENOG4107QWB	Ornithine cyclodeaminase
EWH46_17790	ENOG4105CY0	Metallo-Beta-Lactamase
EWH46_17800	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
EWH46_17805	ENOG4105DIJ	Phosphoethanolamine transferase
EWH46_17830	ENOG4108J5H	Homocysteine s-methyltransferase
EWH46_17845	ENOG4105CPC	Aldo Keto reductase
EWH46_17850	ENOG4108WFY	phasin family
EWH46_17855	ENOG4105C4R	Atp-dependent dna helicase
EWH46_17860	ENOG41080XP	Cbs domain
EWH46_17870	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
EWH46_17875	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
EWH46_17910	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
EWH46_17915	ENOG4105C1A	potassium transporter peripheral membrane
EWH46_17935	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
EWH46_17940	ENOG4107S74	Lysophospholipid transporter LplT
EWH46_17945	ENOG4105C1G	acyl-Coa dehydrogenase
EWH46_17950	ENOG410829K	Lysine exporter protein (Lyse ygga)
EWH46_17955	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_17960	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
EWH46_17965	ENOG41077A9	carbonic anhydrase
EWH46_17970	ENOG4105EJQ	L-serine dehydratase
EWH46_17980	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
EWH46_17995	ENOG4105CHM	Aminotransferase
EWH46_18005	ENOG4106UW1	Major Facilitator superfamily
EWH46_18035	ENOG4105CAF	HipA N-terminal domain protein
EWH46_18050	ENOG4105BZ1	(ABC) transporter
EWH46_18055	ENOG4105D9M	gamma-glutamylcysteine synthetase
EWH46_18060	ENOG4105D9M	gamma-glutamylcysteine synthetase
EWH46_18165	ENOG4105DZR	Type I site-specific deoxyribonuclease
EWH46_18170	ENOG4105DFS	Conserved Protein
EWH46_18255	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EWH46_18340	ENOG4108IJF	Heavy metal efflux pump, CzcA
EWH46_18345	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
EWH46_18365	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
EWH46_18380	ENOG4108Z33	Thiol disulfide Interchange Protein
EWH46_18395	ENOG4105KK4	UPF0060 membrane protein
EWH46_18410	ENOG4107ZQN	disulfide bond
EWH46_18460	ENOG4108C33	Resolvase
EWH46_18465	ENOG4105KT5	UmuD protein
EWH46_18520	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
EWH46_18540	ENOG410600T	transposase
EWH46_18550	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_18565	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
EWH46_18570	ENOG4105D7K	pfkb domain protein
EWH46_18585	ENOG4105CNN	ABC, transporter
EWH46_18590	ENOG4108VYJ	response regulator receiver protein
EWH46_18595	ENOG4105C8Q	Methyl-accepting chemotaxis
EWH46_18600	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
EWH46_18610	ENOG4105CBS	Chea signal transduction histidine kinase
EWH46_18615	ENOG4105CBS	Chea signal transduction histidine kinase
EWH46_18620	ENOG4105BZU	Histidine kinase
EWH46_18630	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
EWH46_18635	ENOG4108V3W	Chemotaxis protein, CheW
EWH46_18640	ENOG4107SDU	Methyl-accepting chemotaxis
EWH46_18645	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
EWH46_18655	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
EWH46_18665	ENOG41081F0	Precorrin-8x methylmutase
EWH46_18670	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
EWH46_18675	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
EWH46_18685	ENOG4108P62	biosynthesis protein (CbiG)
EWH46_18695	ENOG4105E4R	Precorrin-3B C17-methyltransferase
EWH46_18700	ENOG4105NZG	Ferredoxin
EWH46_18710	ENOG4108YYH	Nadph-dependent fmn reductase
EWH46_18715	ENOG4105C1V	Peptidase, M16
EWH46_18725	ENOG4105KHM	amidohydrolase 2
EWH46_18745	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
EWH46_18750	ENOG4108BGM	Quinol dehydrogenase periplasmic component
EWH46_18755	ENOG4105GXZ	Ferredoxin-type protein NapH
EWH46_18765	ENOG4105CUW	cytochrome C-TYPE protein
EWH46_18775	ENOG4108VKQ	nitriC oxide reductase
EWH46_18785	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
EWH46_18795	ENOG4105FAE	von Willebrand factor, type A
EWH46_18800	ENOG4105EYW	Ion transport protein
EWH46_18805	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
EWH46_18810	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
EWH46_18815	ENOG41060IM	Heme exporter protein
EWH46_18825	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
EWH46_18830	ENOG4105DA4	cytochrome c-type biogenesis protein
EWH46_18835	ENOG4107QX9	Thiol disulfide interChange protein
EWH46_18840	ENOG4105KWW	Biogenesis protein
EWH46_18890	ENOG4108KX4	response regulator
EWH46_18895	ENOG4105BZU	Histidine kinase
EWH46_18900	ENOG4105WH1	Two component transcriptional regulator luxr family
EWH46_18935	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
EWH46_18940	ENOG4105ERH	Fumarylacetoacetate hydrolase
EWH46_19030	ENOG4106QJH	hemin transport protein
EWH46_19035	ENOG4107R4I	Periplasmic binding protein
EWH46_19040	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
EWH46_19060	ENOG4105C1J	atp-dependent rna helicase
EWH46_19065	ENOG4105C4R	Atp-dependent dna helicase
EWH46_19080	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
EWH46_19090	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_19095	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
EWH46_19100	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
EWH46_19105	ENOG4105E98	transcriptional regulator DeoR family
EWH46_19110	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
EWH46_19120	ENOG4105E9K	Isocitrate dehydrogenase
EWH46_19135	ENOG4105GAK	amidohydrolase 2
EWH46_19155	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
EWH46_19170	ENOG4105BZS	acriflavin resistance protein
EWH46_19175	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
EWH46_19180	ENOG4105E3J	oxidoreductase
EWH46_19185	ENOG4105EB3	Histidine kinase
EWH46_19190	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
EWH46_19195	ENOG4105CTX	dehydratase
EWH46_19200	ENOG4105UVJ	5-dehydro-4-deoxyglucarate dehydratase
EWH46_19210	ENOG4105EQX	glucarate dehydratase
EWH46_19235	ENOG4105BZC	d-serine deaminase
EWH46_19310	ENOG4105DF3	Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity)
EWH46_19315	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
EWH46_19345	ENOG4105ECQ	AraC Family Transcriptional Regulator
EWH46_19355	ENOG4105C10	Electron transfer flavoprotein
EWH46_19360	ENOG4105DF6	Fe-S oxidoreductase
EWH46_19375	ENOG4108IGT	Dipeptidase
EWH46_19385	ENOG4105DVW	rieske (2Fe-2S)
EWH46_19395	ENOG4108IJ7	Glycine betaine
EWH46_19400	ENOG4108HQS	Glycine betaine
EWH46_19420	ENOG4105C26	Dehydrogenase
EWH46_19425	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
EWH46_19450	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
EWH46_19470	ENOG4105EJQ	L-serine dehydratase
EWH46_19495	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
EWH46_19500	ENOG4107QVI	Methyltransferase, type 11
EWH46_19510	ENOG4107T9Q	phosphonate abc transporter
EWH46_19515	ENOG4105S7S	phosphonate abc transporter
EWH46_19520	ENOG4105D5T	phosphonate abc transporter
EWH46_19525	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
EWH46_19535	ENOG4105E39	Enoyl-CoA hydratase
EWH46_19540	ENOG4105E39	Enoyl-CoA hydratase
EWH46_19545	ENOG4105CHU	acetyl-coa acetyltransferase
EWH46_19565	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
EWH46_19580	ENOG4108ZJF	Glcg protein
EWH46_19600	ENOG4107WAU	Protein tyrosine phosphatase
EWH46_19605	ENOG4107WAU	Protein tyrosine phosphatase
EWH46_19620	ENOG4108YZG	isomerase
EWH46_19625	ENOG4105CMT	Dihydroxyacetone kinase
EWH46_19635	ENOG4108PZW	LysR family Transcriptional regulator
EWH46_19680	ENOG4105NTW	Transcriptional regulator
EWH46_19685	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
EWH46_19700	ENOG4105C0A	alcohol dehydrogenase
EWH46_19720	ENOG4105DR9	pseudouridine synthase
EWH46_19725	ENOG4105F0H	myo-inositol catabolism protein
EWH46_19730	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
EWH46_19735	ENOG4105CIB	oxidoreductase Domain protein
EWH46_19745	ENOG4105FKQ	transcriptional regulator
EWH46_19755	ENOG4105FKQ	transcriptional regulator
EWH46_19770	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
EWH46_19780	ENOG4105CHR	reductase
EWH46_19785	ENOG4105CQB	FAD linked oxidase domain protein
EWH46_19790	ENOG4105ECR	NmrA family
EWH46_19795	ENOG4105KVH	Transcriptional regulator
EWH46_19825	ENOG4105CPC	Aldo Keto reductase
EWH46_19830	ENOG4105KK4	UPF0060 membrane protein
EWH46_19835	ENOG4105C01	Dihydroxy-acid dehydratase
EWH46_19870	ENOG4105E9Z	Nad-dependent epimerase dehydratase
EWH46_19875	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
EWH46_19885	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
EWH46_19890	ENOG4105ETE	Transcriptional regulator (LacI family
EWH46_19895	ENOG4105FDP	GntR family transcriptional regulator
EWH46_19905	ENOG41080T7	secreted protein
EWH46_19950	ENOG4105BZU	Histidine kinase
EWH46_19955	ENOG4105BZU	Histidine kinase