locus-tag	class	description
EWH46_00040	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EWH46_00045	COG1518	maintenance of DNA repeat elements
EWH46_00050	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EWH46_00075	COG2894	cell division
EWH46_00115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EWH46_00120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EWH46_00190	COG1192	Involved in chromosome partitioning
EWH46_00235	COG0482	sulfurtransferase activity
EWH46_00245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EWH46_00250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EWH46_00255	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EWH46_00260	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_00290	COG3706	GGDEF domain
EWH46_00295	COG2813	Specifically methylates the guanine in position
EWH46_00295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EWH46_00300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EWH46_00310	COG0625	glutathione transferase activity
EWH46_00315	COG0402	S-adenosylhomocysteine deaminase activity
EWH46_00325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EWH46_00360	COG2733	membrane
EWH46_00365	COG1414	Transcriptional regulator
EWH46_00390	COG3320	Male sterility
EWH46_00390	COG1022	Amp-dependent synthetase and ligase
EWH46_00405	COG0559	Belongs to the binding-protein-dependent transport system permease family
EWH46_00440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EWH46_00470	COG1024	Enoyl-CoA hydratase
EWH46_00475	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWH46_00485	COG0183	Belongs to the thiolase family
EWH46_00500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWH46_00535	COG1473	amidohydrolase
EWH46_00590	COG0840	transmembrane signaling receptor activity
EWH46_00595	COG0069	glutamate synthase activity
EWH46_00600	COG2885	chlorophyll binding
EWH46_00600	COG3047	cAMP biosynthetic process
EWH46_00605	COG2199	diguanylate cyclase activity
EWH46_00615	COG2900	Belongs to the SlyX family
EWH46_00620	COG0602	queuosine metabolic process
EWH46_00625	COG0720	synthase
EWH46_00645	COG1522	sequence-specific DNA binding
EWH46_00650	COG0745	RESPONSE REGULATOR receiver
EWH46_00650	COG3706	GGDEF domain
EWH46_00655	COG3706	GGDEF domain
EWH46_00670	COG2967	ApaG domain
EWH46_00690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EWH46_00700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EWH46_00720	COG0714	Associated with various cellular activities
EWH46_00730	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EWH46_00745	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EWH46_00755	COG0174	glutamine synthetase
EWH46_00760	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EWH46_00805	COG0546	phosphoglycolate phosphatase activity
EWH46_00825	COG0512	Glutamine amidotransferase of anthranilate synthase
EWH46_00830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EWH46_00835	COG0134	indole-3-glycerol-phosphate synthase activity
EWH46_00840	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EWH46_00860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EWH46_00880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EWH46_00885	COG0081	regulation of translation
EWH46_00890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EWH46_00895	COG0222	ribosome binding
EWH46_00900	COG0085	RNA polymerase activity
EWH46_00905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EWH46_00920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EWH46_00930	COG3706	GGDEF domain
EWH46_00940	COG4181	ATPase activity
EWH46_00975	COG3706	GGDEF domain
EWH46_00980	COG5001	Diguanylate cyclase
EWH46_00980	COG3300	MHYT domain
EWH46_00985	COG3300	MHYT domain
EWH46_00985	COG5001	Diguanylate cyclase
EWH46_00990	COG1086	Polysaccharide biosynthesis protein
EWH46_00995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWH46_01000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EWH46_01015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWH46_01090	COG0673	inositol 2-dehydrogenase activity
EWH46_01095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EWH46_01100	COG2084	Dehydrogenase
EWH46_01130	COG1024	Enoyl-CoA hydratase
EWH46_01140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWH46_01145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWH46_01155	COG0012	GTP binding
EWH46_01165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EWH46_01170	COG0724	RNA recognition motif
EWH46_01175	COG2264	protein methyltransferase activity
EWH46_01210	COG1715	Restriction endonuclease
EWH46_01225	COG5433	transposase activity
EWH46_01240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EWH46_01260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWH46_01270	COG0284	orotidine-5'-phosphate decarboxylase activity
EWH46_01285	COG4269	membrane
EWH46_01290	COG0501	Belongs to the peptidase M48B family
EWH46_01295	COG4269	membrane
EWH46_01315	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EWH46_01325	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EWH46_01330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EWH46_01335	COG0088	Forms part of the polypeptide exit tunnel
EWH46_01340	COG0089	rRNA binding
EWH46_01345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EWH46_01350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EWH46_01355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EWH46_01360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EWH46_01365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EWH46_01370	COG0255	Belongs to the universal ribosomal protein uL29 family
EWH46_01375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EWH46_01380	COG0678	peroxiredoxin activity
EWH46_01390	COG2264	protein methyltransferase activity
EWH46_01395	COG0439	Biotin carboxylase
EWH46_01405	COG3118	belongs to the thioredoxin family
EWH46_01405	COG0492	ferredoxin-NADP+ reductase activity
EWH46_01415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EWH46_01420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EWH46_01430	COG0557	exoribonuclease II activity
EWH46_01435	COG0737	Belongs to the 5'-nucleotidase family
EWH46_01440	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_01450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EWH46_01455	COG0205	6-phosphofructokinase activity
EWH46_01465	COG0583	DNA-binding transcription factor activity
EWH46_01470	COG0583	DNA-binding transcription factor activity
EWH46_01505	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EWH46_01520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EWH46_01530	COG1773	rubredoxin
EWH46_01550	COG0840	transmembrane signaling receptor activity
EWH46_01560	COG3706	GGDEF domain
EWH46_01565	COG0415	Belongs to the DNA photolyase family
EWH46_01570	COG1678	Uncharacterized ACR, COG1678
EWH46_01575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EWH46_01580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EWH46_01585	COG0540	Belongs to the ATCase OTCase family
EWH46_01605	COG1881	PFAM PEBP family protein
EWH46_01615	COG2255	four-way junction helicase activity
EWH46_01620	COG0632	four-way junction helicase activity
EWH46_01625	COG2197	response regulator
EWH46_01630	COG4585	Histidine kinase
EWH46_01635	COG1702	phosphate starvation-inducible protein PhoH
EWH46_01640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EWH46_01645	COG1505	serine-type exopeptidase activity
EWH46_01650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EWH46_01660	COG0183	Belongs to the thiolase family
EWH46_01685	COG1703	isobutyryl-CoA mutase activity
EWH46_01685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EWH46_01685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EWH46_01690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EWH46_01695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EWH46_01700	COG1116	anion transmembrane transporter activity
EWH46_01710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EWH46_01720	COG5001	Diguanylate cyclase
EWH46_01720	COG3300	MHYT domain
EWH46_01725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EWH46_01730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EWH46_01740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EWH46_01750	COG0523	cobalamin synthesis protein
EWH46_01760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EWH46_01765	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EWH46_01785	COG1937	Protein conserved in bacteria
EWH46_01810	COG0640	Transcriptional regulator
EWH46_01815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EWH46_01820	COG4654	Cytochrome c, class I
EWH46_01855	COG2391	methyltransferase activity
EWH46_01860	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWH46_01880	COG4654	Cytochrome c, class I
EWH46_01905	COG0583	DNA-binding transcription factor activity
EWH46_01930	COG0577	efflux transmembrane transporter activity
EWH46_01930	COG1136	(ABC) transporter
EWH46_01935	COG1136	(ABC) transporter
EWH46_01935	COG0577	efflux transmembrane transporter activity
EWH46_01950	COG3706	GGDEF domain
EWH46_01955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EWH46_01970	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EWH46_01980	COG0675	Transposase, IS605 OrfB family
EWH46_01990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EWH46_02050	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWH46_02065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EWH46_02070	COG0425	Belongs to the sulfur carrier protein TusA family
EWH46_02080	COG0248	Ppx GppA phosphatase
EWH46_02085	COG0412	Dienelactone hydrolase
EWH46_02110	COG1058	Belongs to the CinA family
EWH46_02110	COG1546	Belongs to the CinA family
EWH46_02125	COG3852	Histidine kinase
EWH46_02145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EWH46_02150	COG0436	Aminotransferase
EWH46_02155	COG0697	spore germination
EWH46_02160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWH46_02165	COG0384	phenazine biosynthesis protein PhzF
EWH46_02195	COG0356	it plays a direct role in the translocation of protons across the membrane
EWH46_02205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EWH46_02210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EWH46_02215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EWH46_02220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EWH46_02225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EWH46_02230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EWH46_02250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EWH46_02255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EWH46_02265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EWH46_02270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWH46_02315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EWH46_02325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EWH46_02335	COG3158	transport of potassium into the cell
EWH46_02345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWH46_02350	COG0588	phosphoglycerate mutase activity
EWH46_02360	COG0739	heme binding
EWH46_02365	COG0653	protein targeting
EWH46_02385	COG0584	glycerophosphoryl diester phosphodiesterase
EWH46_02400	COG2226	methyltransferase
EWH46_02405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWH46_02420	COG0489	protein tyrosine kinase activity
EWH46_02430	COG3267	Type II secretory pathway component ExeA
EWH46_02430	COG3409	Peptidoglycan-binding domain 1 protein
EWH46_02440	COG0742	ribosomal rna small subunit methyltransferase
EWH46_02445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EWH46_02450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EWH46_02455	COG0193	aminoacyl-tRNA hydrolase activity
EWH46_02460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EWH46_02465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EWH46_02475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EWH46_02490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EWH46_02510	COG1660	Displays ATPase and GTPase activities
EWH46_02515	COG0497	DNA recombination
EWH46_02520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EWH46_02525	COG1420	regulation of RNA biosynthetic process
EWH46_02540	COG0732	type I restriction modification DNA specificity domain
EWH46_02560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EWH46_02600	COG1598	PFAM Uncharacterised protein family UPF0150
EWH46_02610	COG0582	viral genome integration into host DNA
EWH46_02625	COG0326	Molecular chaperone. Has ATPase activity
EWH46_02675	COG0629	single-stranded DNA binding
EWH46_02685	COG0514	ATP-dependent DNA helicase (RecQ)
EWH46_02710	COG3243	poly(R)-hydroxyalkanoic acid synthase
EWH46_02715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EWH46_02725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EWH46_02770	COG0494	nUDIX hydrolase
EWH46_02775	COG0442	prolyl-tRNA aminoacylation
EWH46_02790	COG0670	Belongs to the BI1 family
EWH46_02795	COG1215	transferase activity, transferring glycosyl groups
EWH46_02810	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EWH46_02815	COG4310	Domain of unknown function (DUF2172)
EWH46_02820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EWH46_02825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EWH46_02840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EWH46_02850	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EWH46_02855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EWH46_02865	COG0583	DNA-binding transcription factor activity
EWH46_02880	COG2205	protein histidine kinase activity
EWH46_02910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWH46_02950	COG0840	transmembrane signaling receptor activity
EWH46_02975	COG0004	ammonium transporteR
EWH46_03000	COG0543	2 iron, 2 sulfur cluster binding
EWH46_03000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EWH46_03005	COG0268	Binds directly to 16S ribosomal RNA
EWH46_03010	COG0728	peptidoglycan biosynthetic process
EWH46_03020	COG0628	permease
EWH46_03025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EWH46_03035	COG0617	tRNA 3'-terminal CCA addition
EWH46_03050	COG0306	phosphate transporter
EWH46_03065	COG0228	four-way junction DNA binding
EWH46_03070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EWH46_03075	COG0336	Belongs to the RNA methyltransferase TrmD family
EWH46_03080	COG0335	large ribosomal subunit rRNA binding
EWH46_03090	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EWH46_03105	COG1162	GTPase activity
EWH46_03110	COG0501	Belongs to the peptidase M48B family
EWH46_03115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EWH46_03130	COG1960	acyl-CoA dehydrogenase activity
EWH46_03135	COG0410	ABC transporter
EWH46_03140	COG0411	ABC transporter
EWH46_03165	COG1024	Enoyl-CoA hydratase
EWH46_03175	COG3245	cytochrome
EWH46_03185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EWH46_03195	COG1722	exodeoxyribonuclease VII activity
EWH46_03200	COG4638	Rieske (2fe-2S)
EWH46_03215	COG0589	response to stress
EWH46_03235	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_03240	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EWH46_03240	COG2273	Hydrolase Family 16
EWH46_03250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EWH46_03255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWH46_03255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EWH46_03260	COG0724	RNA recognition motif
EWH46_03270	COG1192	Involved in chromosome partitioning
EWH46_03290	COG0830	nickel cation binding
EWH46_03295	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EWH46_03305	COG0804	urea catabolic process
EWH46_03310	COG0832	Belongs to the urease beta subunit family
EWH46_03320	COG0831	urea catabolic process
EWH46_03325	COG0784	Response regulator, receiver
EWH46_03325	COG2198	Histidine kinase
EWH46_03325	COG5002	protein histidine kinase activity
EWH46_03335	COG0596	Alpha beta hydrolase
EWH46_03340	COG5001	Diguanylate cyclase
EWH46_03340	COG3447	MASE1 domain protein
EWH46_03340	COG5002	protein histidine kinase activity
EWH46_03355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EWH46_03370	COG1172	Belongs to the binding-protein-dependent transport system permease family
EWH46_03405	COG0840	transmembrane signaling receptor activity
EWH46_03445	COG1741	Belongs to the pirin family
EWH46_03450	COG0583	DNA-binding transcription factor activity
EWH46_03455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EWH46_03465	COG2852	Protein conserved in bacteria
EWH46_03475	COG1002	Type II restriction enzyme, methylase subunits
EWH46_03480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EWH46_03490	COG1595	DNA-templated transcription, initiation
EWH46_03500	COG3220	belongs to the UPF0276 family
EWH46_03520	COG0167	dihydroorotate dehydrogenase activity
EWH46_03525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EWH46_03545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EWH46_03565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EWH46_03570	COG0077	Prephenate dehydratase
EWH46_03570	COG1605	Chorismate mutase
EWH46_03575	COG0287	Prephenate dehydrogenase
EWH46_03580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EWH46_03590	COG0776	regulation of translation
EWH46_03600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EWH46_03620	COG0829	nickel cation binding
EWH46_03635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EWH46_03640	COG1116	anion transmembrane transporter activity
EWH46_03645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EWH46_03660	COG1051	belongs to the nudix hydrolase family
EWH46_03670	COG0076	glutamate decarboxylase activity
EWH46_03690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EWH46_03700	COG0586	Pfam SNARE associated Golgi protein
EWH46_03710	COG0860	N-Acetylmuramoyl-L-alanine amidase
EWH46_03715	COG0802	atpase or kinase
EWH46_03720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EWH46_03740	COG0765	amino acid transport
EWH46_03755	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EWH46_03765	COG2833	Protein of unknown function (DUF455)
EWH46_03770	COG2755	lipolytic protein G-D-S-L family
EWH46_03770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EWH46_03785	COG0277	FAD linked oxidase domain protein
EWH46_03790	COG0277	FAD linked oxidase domain protein
EWH46_03795	COG0247	lactate metabolic process
EWH46_03800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EWH46_03805	COG0148	phosphopyruvate hydratase activity
EWH46_03810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EWH46_03815	COG0504	CTP synthase activity
EWH46_03820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EWH46_03825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EWH46_03845	COG2267	carboxylic ester hydrolase activity
EWH46_03855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EWH46_03880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EWH46_03885	COG1045	serine acetyltransferase
EWH46_03900	COG0521	Mo-molybdopterin cofactor biosynthetic process
EWH46_03905	COG3028	Belongs to the UPF0307 family
EWH46_03910	COG0312	modulator of DNA gyrase
EWH46_03915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EWH46_03920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EWH46_03950	COG0697	spore germination
EWH46_04025	COG3501	Rhs element vgr protein
EWH46_04035	COG3209	COG3209 Rhs family protein
EWH46_04095	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWH46_04165	COG0631	protein serine/threonine phosphatase activity
EWH46_04205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EWH46_04220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EWH46_04225	COG0196	riboflavin kinase activity
EWH46_04230	COG1187	pseudouridine synthase activity
EWH46_04240	COG1960	acyl-CoA dehydrogenase activity
EWH46_04245	COG1960	acyl-CoA dehydrogenase activity
EWH46_04255	COG1666	GTP binding
EWH46_04260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EWH46_04265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EWH46_04285	COG0659	secondary active sulfate transmembrane transporter activity
EWH46_04310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWH46_04310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWH46_04320	COG3706	GGDEF domain
EWH46_04320	COG0745	RESPONSE REGULATOR receiver
EWH46_04325	COG0489	protein tyrosine kinase activity
EWH46_04350	COG3383	formate dehydrogenase (NAD+) activity
EWH46_04375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EWH46_04390	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_04395	COG2030	dehydratase
EWH46_04405	COG0784	Response regulator, receiver
EWH46_04405	COG2205	protein histidine kinase activity
EWH46_04410	COG4654	Cytochrome c, class I
EWH46_04415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EWH46_04430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EWH46_04450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EWH46_04465	COG1609	Transcriptional regulator
EWH46_04490	COG0204	Acyl-transferase
EWH46_04490	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_04505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EWH46_04525	COG0351	phosphomethylpyrimidine kinase
EWH46_04550	COG0516	GMP reductase activity
EWH46_04555	COG3300	MHYT domain
EWH46_04555	COG5001	Diguanylate cyclase
EWH46_04585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EWH46_04595	COG1132	(ABC) transporter
EWH46_04610	COG0745	RESPONSE REGULATOR receiver
EWH46_04610	COG3706	GGDEF domain
EWH46_04615	COG1136	(ABC) transporter
EWH46_04620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EWH46_04625	COG2814	Major facilitator Superfamily
EWH46_04635	COG0778	Nitroreductase
EWH46_04645	COG1024	Enoyl-CoA hydratase
EWH46_04650	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_04655	COG2951	lytic endotransglycosylase activity
EWH46_04660	COG0585	pseudouridine synthase activity
EWH46_04675	COG0142	geranyltranstransferase activity
EWH46_04680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EWH46_04685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EWH46_04690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EWH46_04695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EWH46_04720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWH46_04755	COG0277	FAD linked oxidase domain protein
EWH46_04760	COG0277	FAD linked oxidase domain protein
EWH46_04765	COG0247	lactate metabolic process
EWH46_04775	COG0343	queuine tRNA-ribosyltransferase activity
EWH46_04785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EWH46_04795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EWH46_04815	COG3634	alkyl hydroperoxide reductase activity
EWH46_04825	COG0735	belongs to the Fur family
EWH46_04855	COG3128	pkhd-type hydroxylase
EWH46_04890	COG0717	Belongs to the dCTP deaminase family
EWH46_04915	COG1815	bacterial-type flagellum-dependent cell motility
EWH46_04920	COG1558	bacterial-type flagellum-dependent cell motility
EWH46_04925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EWH46_04930	COG1749	Flagellar hook protein flgE
EWH46_04940	COG4786	Flagellar basal body rod
EWH46_04950	COG1706	bacterial-type flagellum-dependent cell motility
EWH46_04960	COG1256	bacterial-type flagellum assembly
EWH46_04970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EWH46_04990	COG5002	protein histidine kinase activity
EWH46_04990	COG0784	Response regulator, receiver
EWH46_04990	COG2205	protein histidine kinase activity
EWH46_05010	COG2267	carboxylic ester hydrolase activity
EWH46_05040	COG0667	Aldo Keto reductase
EWH46_05050	COG0251	oxidation-reduction process
EWH46_05055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EWH46_05065	COG0009	L-threonylcarbamoyladenylate synthase
EWH46_05070	COG0613	PHP domain protein
EWH46_05075	COG2133	pyrroloquinoline quinone binding
EWH46_05090	COG0583	DNA-binding transcription factor activity
EWH46_05095	COG1960	acyl-CoA dehydrogenase activity
EWH46_05100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EWH46_05110	COG0484	heat shock protein binding
EWH46_05115	COG0443	Heat shock 70 kDa protein
EWH46_05120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EWH46_05140	COG0642	Histidine kinase
EWH46_05175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EWH46_05195	COG0653	protein targeting
EWH46_05210	COG0745	RESPONSE REGULATOR receiver
EWH46_05210	COG3706	GGDEF domain
EWH46_05220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EWH46_05230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EWH46_05245	COG0405	Gamma-glutamyltransferase
EWH46_05255	COG0563	adenylate kinase activity
EWH46_05260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EWH46_05265	COG2835	tetraacyldisaccharide 4'-kinase activity
EWH46_05270	COG1663	tetraacyldisaccharide 4'-kinase activity
EWH46_05275	COG0848	biopolymer transport protein
EWH46_05280	COG0811	peptide transport
EWH46_05285	COG1570	exodeoxyribonuclease VII activity
EWH46_05295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EWH46_05310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWH46_05320	COG0544	peptidyl-prolyl cis-trans isomerase activity
EWH46_05325	COG0740	serine-type endopeptidase activity
EWH46_05330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EWH46_05335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EWH46_05365	COG0305	Participates in initiation and elongation during chromosome replication
EWH46_05370	COG0505	Belongs to the CarA family
EWH46_05375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EWH46_05380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWH46_05390	COG1534	Rna-binding protein
EWH46_05395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EWH46_05400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWH46_05420	COG1960	acyl-CoA dehydrogenase activity
EWH46_05435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EWH46_05440	COG0643	Histidine kinase
EWH46_05440	COG2198	Histidine kinase
EWH46_05445	COG0840	transmembrane signaling receptor activity
EWH46_05460	COG0840	transmembrane signaling receptor activity
EWH46_05465	COG0515	serine threonine protein kinase
EWH46_05465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EWH46_05485	COG1136	(ABC) transporter
EWH46_05500	COG0303	'Molybdopterin
EWH46_05510	COG1126	abc transporter atp-binding protein
EWH46_05525	COG2414	aldehyde ferredoxin oxidoreductase
EWH46_05560	COG4772	TonB-dependent receptor
EWH46_05575	COG3300	MHYT domain
EWH46_05575	COG5001	Diguanylate cyclase
EWH46_05590	COG0302	gtp cyclohydrolase
EWH46_05595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EWH46_05605	COG4251	negative regulation of phosphorylation
EWH46_05615	COG0477	Major facilitator Superfamily
EWH46_05645	COG3437	response regulator, receiver
EWH46_05645	COG3850	Histidine kinase
EWH46_05645	COG4999	Histidine kinase
EWH46_05645	COG2205	protein histidine kinase activity
EWH46_05655	COG0492	ferredoxin-NADP+ reductase activity
EWH46_05670	COG2895	sulfate adenylyltransferase (ATP) activity
EWH46_05675	COG0175	sulfate reduction
EWH46_05680	COG0175	sulfate reduction
EWH46_05695	COG0730	response to heat
EWH46_05705	COG2217	Heavy metal translocating P-type atpase
EWH46_05715	COG3278	Belongs to the heme-copper respiratory oxidase family
EWH46_05750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWH46_05755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EWH46_05770	COG1278	Cold shock
EWH46_05775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EWH46_05780	COG0542	response to heat
EWH46_05785	COG1773	rubredoxin
EWH46_05790	COG3228	Belongs to the MtfA family
EWH46_05795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWH46_05800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EWH46_05815	COG0215	cysteine-tRNA ligase activity
EWH46_05830	COG0037	tRNA processing
EWH46_05855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EWH46_05860	COG0066	3-isopropylmalate dehydratase activity
EWH46_05865	COG0473	3-isopropylmalate dehydrogenase activity
EWH46_05870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EWH46_05880	COG0101	tRNA pseudouridine synthase activity
EWH46_05885	COG0135	phosphoribosylanthranilate isomerase activity
EWH46_05890	COG0133	tryptophan synthase activity
EWH46_05895	COG0159	tryptophan synthase activity
EWH46_05900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EWH46_05905	COG0285	dihydrofolate synthase activity
EWH46_05920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EWH46_05930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EWH46_05980	COG0859	PFAM glycosyl transferase family 9
EWH46_06000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EWH46_06010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWH46_06015	COG1309	transcriptional regulator
EWH46_06030	COG0513	Belongs to the DEAD box helicase family
EWH46_06040	COG0668	transmembrane transport
EWH46_06050	COG3706	GGDEF domain
EWH46_06060	COG2501	S4 domain
EWH46_06090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EWH46_06105	COG1215	transferase activity, transferring glycosyl groups
EWH46_06135	COG1132	(ABC) transporter
EWH46_06140	COG0850	regulation of cytokinetic process
EWH46_06150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EWH46_06155	COG2843	Capsule synthesis protein
EWH46_06160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWH46_06170	COG4335	DNA alkylation repair
EWH46_06180	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EWH46_06180	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EWH46_06185	COG2197	response regulator
EWH46_06200	COG1610	YqeY-like protein
EWH46_06205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EWH46_06210	COG2081	HI0933 family
EWH46_06235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EWH46_06240	COG1131	(ABC) transporter
EWH46_06285	COG2824	Alkylphosphonate utilization operon protein PhnA
EWH46_06290	COG1061	Type III restriction enzyme res subunit
EWH46_06295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EWH46_06305	COG0322	excinuclease ABC activity
EWH46_06310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EWH46_06320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWH46_06330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EWH46_06340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EWH46_06345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EWH46_06355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EWH46_06380	COG0811	peptide transport
EWH46_06385	COG0824	Thioesterase
EWH46_06390	COG0515	serine threonine protein kinase
EWH46_06395	COG0436	Aminotransferase
EWH46_06405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EWH46_06415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWH46_06415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EWH46_06445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EWH46_06450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EWH46_06455	COG0741	lytic transglycosylase activity
EWH46_06460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EWH46_06470	COG0259	pyridoxamine-phosphate oxidase activity
EWH46_06475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EWH46_06495	COG0800	Aldolase
EWH46_06500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EWH46_06520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EWH46_06525	COG0427	acetyl-CoA hydrolase
EWH46_06545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EWH46_06550	COG0346	lactoylglutathione lyase activity
EWH46_06565	COG0714	Associated with various cellular activities
EWH46_06570	COG0123	including yeast histone deacetylase and acetoin utilization protein
EWH46_06610	COG0488	(ABC) transporter
EWH46_06620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EWH46_06645	COG0028	Belongs to the TPP enzyme family
EWH46_06650	COG0440	acetolactate synthase activity
EWH46_06655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EWH46_06665	COG1183	phosphatidylcholine synthase activity
EWH46_06670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EWH46_06680	COG1414	Transcriptional regulator
EWH46_06690	COG0567	Dehydrogenase, E1 component
EWH46_06695	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWH46_06700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWH46_06705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EWH46_06710	COG0631	protein serine/threonine phosphatase activity
EWH46_06720	COG1199	ATP-dependent helicase activity
EWH46_06730	COG0564	pseudouridine synthase activity
EWH46_06735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EWH46_06740	COG1187	pseudouridine synthase activity
EWH46_06745	COG0105	UTP biosynthetic process
EWH46_06750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EWH46_06765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EWH46_06770	COG0124	histidyl-tRNA synthetase
EWH46_06785	COG1160	GTP binding
EWH46_06790	COG1923	regulation of RNA biosynthetic process
EWH46_06795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EWH46_06800	COG0330	HflC and HflK could
EWH46_06805	COG0330	HflC and HflK could
EWH46_06815	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EWH46_06820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EWH46_06825	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EWH46_06845	COG0557	exoribonuclease II activity
EWH46_06850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EWH46_06850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EWH46_06865	COG0052	Belongs to the universal ribosomal protein uS2 family
EWH46_06870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EWH46_06875	COG0528	UMP kinase activity
EWH46_06880	COG0233	cytoplasmic translational termination
EWH46_06890	COG0575	Belongs to the CDS family
EWH46_06895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EWH46_06900	COG0750	zinc metalloprotease
EWH46_06915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWH46_06920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EWH46_06925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWH46_06930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EWH46_06935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EWH46_06940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWH46_06945	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EWH46_06960	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWH46_06965	COG0360	Binds together with S18 to 16S ribosomal RNA
EWH46_06970	COG2965	DNA replication, synthesis of RNA primer
EWH46_06975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EWH46_06980	COG0359	binds to the 23S rRNA
EWH46_06990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EWH46_07000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EWH46_07005	COG0573	inorganic phosphate transmembrane transporter activity
EWH46_07010	COG0581	inorganic phosphate transmembrane transporter activity
EWH46_07015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EWH46_07040	COG0254	rRNA binding
EWH46_07045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EWH46_07065	COG0084	hydrolase, TatD family'
EWH46_07100	COG2814	Major facilitator Superfamily
EWH46_07160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EWH46_07175	COG1178	ABC-type Fe3 transport system permease component
EWH46_07180	COG3842	ATPase activity
EWH46_07185	COG0793	Belongs to the peptidase S41A family
EWH46_07190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EWH46_07210	COG1216	Glycosyl transferase, family 2
EWH46_07230	COG0745	RESPONSE REGULATOR receiver
EWH46_07235	COG2205	protein histidine kinase activity
EWH46_07250	COG0779	Required for maturation of 30S ribosomal subunits
EWH46_07255	COG0195	Participates in both transcription termination and antitermination
EWH46_07255	COG2251	uridine kinase activity
EWH46_07260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EWH46_07265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EWH46_07305	COG0420	3'-5' exonuclease activity
EWH46_07310	COG0419	ATPase involved in DNA repair
EWH46_07320	COG2017	converts alpha-aldose to the beta-anomer
EWH46_07325	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EWH46_07330	COG1085	galactose-1-phosphate uridylyltransferase
EWH46_07340	COG0395	ABC-type sugar transport system, permease component
EWH46_07345	COG1175	transmembrane transport
EWH46_07360	COG3842	ATPase activity
EWH46_07380	COG0577	efflux transmembrane transporter activity
EWH46_07380	COG1136	(ABC) transporter
EWH46_07385	COG0577	efflux transmembrane transporter activity
EWH46_07385	COG1136	(ABC) transporter
EWH46_07390	COG1136	(ABC) transporter
EWH46_07390	COG0577	efflux transmembrane transporter activity
EWH46_07395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EWH46_07405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EWH46_07425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EWH46_07430	COG2867	negative regulation of translational initiation
EWH46_07435	COG2914	Belongs to the UPF0125 (RnfH) family
EWH46_07455	COG0519	Catalyzes the synthesis of GMP from XMP
EWH46_07455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EWH46_07480	COG4305	rare lipoprotein A
EWH46_07505	COG4302	ethanolamine ammonia-lyase activity
EWH46_07510	COG4303	Ethanolamine ammonia lyase large subunit
EWH46_07515	COG0531	amino acid
EWH46_07535	COG0861	Integral membrane protein TerC family
EWH46_07550	COG1982	Orn Lys Arg decarboxylase major
EWH46_07555	COG1739	Uncharacterized protein family UPF0029
EWH46_07570	COG0443	Heat shock 70 kDa protein
EWH46_07575	COG0443	Heat shock 70 kDa protein
EWH46_07585	COG0688	phosphatidylethanolamine metabolic process
EWH46_07610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EWH46_07635	COG3045	CreA protein
EWH46_07655	COG0488	(ABC) transporter
EWH46_07690	COG5001	Diguanylate cyclase
EWH46_07690	COG1716	ATPase activity
EWH46_07730	COG2146	nitrite reductase [NAD(P)H] activity
EWH46_07735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EWH46_07745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWH46_07770	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EWH46_07775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EWH46_07785	COG0436	Aminotransferase
EWH46_07810	COG1763	Mo-molybdopterin cofactor biosynthetic process
EWH46_07815	COG0303	'Molybdopterin
EWH46_07825	COG0314	molybdopterin synthase activity
EWH46_07845	COG1047	Peptidyl-prolyl cis-trans
EWH46_07850	COG2850	peptidyl-arginine hydroxylation
EWH46_07860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EWH46_07865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EWH46_07870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EWH46_07880	COG0187	DNA topoisomerase II activity
EWH46_07885	COG2197	response regulator
EWH46_07910	COG0745	RESPONSE REGULATOR receiver
EWH46_07915	COG0642	Histidine kinase
EWH46_07945	COG2308	Evidence 4 Homologs of previously reported genes of
EWH46_07960	COG2308	Evidence 4 Homologs of previously reported genes of
EWH46_07960	COG2307	Protein conserved in bacteria
EWH46_07965	COG1305	Transglutaminase-like
EWH46_07985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWH46_07995	COG0436	Aminotransferase
EWH46_08000	COG0583	DNA-binding transcription factor activity
EWH46_08020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EWH46_08045	COG0745	RESPONSE REGULATOR receiver
EWH46_08050	COG0840	transmembrane signaling receptor activity
EWH46_08065	COG0675	Transposase, IS605 OrfB family
EWH46_08085	COG0488	(ABC) transporter
EWH46_08090	COG2951	lytic endotransglycosylase activity
EWH46_08105	COG2200	EAL domain
EWH46_08120	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_08125	COG3132	Protein of unknown function, DUF480
EWH46_08130	COG1322	Protein conserved in bacteria
EWH46_08135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EWH46_08135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EWH46_08145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EWH46_08150	COG0626	cystathionine gamma-synthase activity
EWH46_08160	COG2205	protein histidine kinase activity
EWH46_08165	COG1643	Atp-dependent helicase
EWH46_08210	COG0840	transmembrane signaling receptor activity
EWH46_08280	COG0723	plastoquinol--plastocyanin reductase activity
EWH46_08285	COG1294	oxidase, subunit
EWH46_08300	COG3604	Transcriptional regulator
EWH46_08315	COG0010	Belongs to the arginase family
EWH46_08320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EWH46_08325	COG2224	Isocitrate lyase
EWH46_08330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EWH46_08335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EWH46_08340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EWH46_08345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EWH46_08350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EWH46_08355	COG0072	phenylalanine-tRNA ligase activity
EWH46_08355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EWH46_08360	COG0776	regulation of translation
EWH46_08405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EWH46_08420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EWH46_08435	COG4232	protein-disulfide reductase activity
EWH46_08440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EWH46_08450	COG0560	Phosphoserine phosphatase
EWH46_08460	COG0583	DNA-binding transcription factor activity
EWH46_08465	COG4251	negative regulation of phosphorylation
EWH46_08470	COG0784	Response regulator, receiver
EWH46_08485	COG1960	acyl-CoA dehydrogenase activity
EWH46_08490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EWH46_08490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EWH46_08500	COG1012	belongs to the aldehyde dehydrogenase family
EWH46_08535	COG0242	peptide deformylase activity
EWH46_08550	COG1982	Orn Lys Arg decarboxylase major
EWH46_08555	COG2207	Transcriptional regulator
EWH46_08555	COG3708	Transcriptional regulator
EWH46_08560	COG0697	spore germination
EWH46_08575	COG0366	Alpha amylase catalytic
EWH46_08585	COG1523	belongs to the glycosyl hydrolase 13 family
EWH46_08590	COG0033	Phosphoglucomutase
EWH46_08595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EWH46_08600	COG0297	glycogen (starch) synthase activity
EWH46_08605	COG0058	SHG alpha-glucan phosphorylase activity
EWH46_08615	COG1215	transferase activity, transferring glycosyl groups
EWH46_08620	COG2050	protein possibly involved in aromatic compounds catabolism
EWH46_08670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EWH46_08675	COG2814	Major facilitator Superfamily
EWH46_08695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EWH46_08700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EWH46_08705	COG4181	ATPase activity
EWH46_08735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EWH46_08740	COG2267	carboxylic ester hydrolase activity
EWH46_08745	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_08755	COG0745	RESPONSE REGULATOR receiver
EWH46_08760	COG2205	protein histidine kinase activity
EWH46_08765	COG4251	negative regulation of phosphorylation
EWH46_08775	COG0826	peptidase U32
EWH46_08785	COG0328	RNA-DNA hybrid ribonuclease activity
EWH46_08790	COG2226	methyltransferase
EWH46_08795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWH46_08800	COG1388	LysM domain
EWH46_08800	COG0741	lytic transglycosylase activity
EWH46_08805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EWH46_08810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EWH46_08815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EWH46_08820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EWH46_08825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EWH46_08830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EWH46_08835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EWH46_08845	COG4566	intracellular signal transduction
EWH46_08850	COG0084	hydrolase, TatD family'
EWH46_08865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EWH46_08870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EWH46_08895	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EWH46_08920	COG0123	including yeast histone deacetylase and acetoin utilization protein
EWH46_08975	COG2032	superoxide dismutase activity
EWH46_08980	COG2183	response to ionizing radiation
EWH46_08985	COG1136	(ABC) transporter
EWH46_09000	COG0431	NADPH-dependent FMN reductase
EWH46_09005	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_09010	COG2130	NADP-dependent
EWH46_09030	COG1960	acyl-CoA dehydrogenase activity
EWH46_09035	COG0183	Belongs to the thiolase family
EWH46_09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWH46_09040	COG1024	Enoyl-CoA hydratase
EWH46_09075	COG0559	Belongs to the binding-protein-dependent transport system permease family
EWH46_09095	COG2917	probably involved in intracellular septation
EWH46_09105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWH46_09110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EWH46_09120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EWH46_09125	COG3842	ATPase activity
EWH46_09135	COG1176	ABC-type spermidine putrescine transport system, permease component I
EWH46_09140	COG1177	transmembrane transport
EWH46_09185	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EWH46_09205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWH46_09215	COG0753	catalase activity
EWH46_09220	COG0542	response to heat
EWH46_09230	COG1538	Outer membrane efflux protein
EWH46_09235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWH46_09240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWH46_09260	COG1126	abc transporter atp-binding protein
EWH46_09265	COG0765	amino acid transport
EWH46_09270	COG0765	amino acid transport
EWH46_09275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWH46_09280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWH46_09285	COG2119	membrane
EWH46_09290	COG3422	double-strand break repair
EWH46_09300	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EWH46_09310	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_09355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EWH46_09355	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EWH46_09360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EWH46_09365	COG1840	ABC-type Fe3 transport system, periplasmic component
EWH46_09370	COG2916	Histone family protein nucleoid-structuring protein H-NS
EWH46_09375	COG0791	NLP P60 protein
EWH46_09380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EWH46_09385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EWH46_09395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EWH46_09395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EWH46_09405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EWH46_09415	COG2030	dehydratase
EWH46_09415	COG1012	belongs to the aldehyde dehydrogenase family
EWH46_09430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EWH46_09435	COG2151	metal-sulfur cluster biosynthetic enzyme
EWH46_09440	COG3396	Phenylacetate-CoA oxygenase
EWH46_09445	COG3460	Phenylacetate-CoA oxygenase
EWH46_09450	COG3396	Phenylacetate-CoA oxygenase
EWH46_09460	COG2050	protein possibly involved in aromatic compounds catabolism
EWH46_09465	COG1024	Enoyl-CoA hydratase
EWH46_09475	COG1619	proteins homologs of microcin C7 resistance protein MccF
EWH46_09480	COG0590	tRNA wobble adenosine to inosine editing
EWH46_09485	COG0745	RESPONSE REGULATOR receiver
EWH46_09495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EWH46_09500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EWH46_09505	COG0174	glutamine synthetase
EWH46_09530	COG1012	belongs to the aldehyde dehydrogenase family
EWH46_09535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EWH46_09540	COG3842	ATPase activity
EWH46_09545	COG1176	ABC-type spermidine putrescine transport system, permease component I
EWH46_09550	COG1177	transmembrane transport
EWH46_09555	COG0697	spore germination
EWH46_09560	COG1846	Transcriptional regulator
EWH46_09565	COG1764	response to oxidative stress
EWH46_09575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EWH46_09585	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_09590	COG0183	Belongs to the thiolase family
EWH46_09595	COG3243	poly(R)-hydroxyalkanoic acid synthase
EWH46_09620	COG2274	protein secretion by the type I secretion system
EWH46_09625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWH46_09685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EWH46_09700	COG0823	Involved in the tonB-independent uptake of proteins
EWH46_09730	COG0438	transferase activity, transferring glycosyl groups
EWH46_09730	COG1216	Glycosyl transferase, family 2
EWH46_09740	COG1530	ribonuclease E activity
EWH46_09745	COG0424	maF-like protein
EWH46_09750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EWH46_09755	COG0799	negative regulation of ribosome biogenesis
EWH46_09760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EWH46_09765	COG0408	coproporphyrinogen oxidase activity
EWH46_09770	COG0151	Belongs to the GarS family
EWH46_09775	COG2194	sulfuric ester hydrolase activity
EWH46_09780	COG0217	transcriptional regulatory protein
EWH46_09790	COG1136	(ABC) transporter
EWH46_09790	COG0577	efflux transmembrane transporter activity
EWH46_09810	COG3275	phosphorelay sensor kinase activity
EWH46_09835	COG2351	hydroxyisourate hydrolase activity
EWH46_09845	COG0484	heat shock protein binding
EWH46_09865	COG0307	riboflavin synthase, alpha
EWH46_09875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EWH46_09890	COG1024	Enoyl-CoA hydratase
EWH46_09895	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EWH46_09900	COG1960	acyl-CoA dehydrogenase activity
EWH46_09905	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_09915	COG1301	dicarboxylic acid transport
EWH46_09945	COG0848	biopolymer transport protein
EWH46_09960	COG4172	Belongs to the ABC transporter superfamily
EWH46_09965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EWH46_09985	COG4206	TonB-dependent receptor
EWH46_09990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EWH46_09995	COG4771	TonB-dependent receptor
EWH46_10005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EWH46_10015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EWH46_10020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EWH46_10050	COG3162	membrane
EWH46_10055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWH46_10060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EWH46_10075	COG0653	protein targeting
EWH46_10080	COG0745	RESPONSE REGULATOR receiver
EWH46_10095	COG3622	Belongs to the hyi family
EWH46_10100	COG2354	Protein conserved in bacteria
EWH46_10110	COG0745	RESPONSE REGULATOR receiver
EWH46_10120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EWH46_10135	COG0642	Histidine kinase
EWH46_10145	COG1175	transmembrane transport
EWH46_10160	COG0837	glucose binding
EWH46_10175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EWH46_10185	COG1196	nuclear chromosome segregation
EWH46_10190	COG0436	Aminotransferase
EWH46_10195	COG2171	N-acyltransferase activity
EWH46_10205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EWH46_10210	COG2890	protein-(glutamine-N5) methyltransferase activity
EWH46_10215	COG0840	transmembrane signaling receptor activity
EWH46_10235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EWH46_10240	COG1968	undecaprenyl-diphosphatase activity
EWH46_10245	COG1187	pseudouridine synthase activity
EWH46_10250	COG1309	transcriptional regulator
EWH46_10255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EWH46_10255	COG0047	phosphoribosylformylglycinamidine synthase activity
EWH46_10260	COG0579	oxidoreductase
EWH46_10265	COG0024	Methionine aminopeptidase
EWH46_10280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWH46_10305	COG0840	transmembrane signaling receptor activity
EWH46_10345	COG0583	DNA-binding transcription factor activity
EWH46_10350	COG2828	Protein conserved in bacteria
EWH46_10360	COG0583	DNA-binding transcription factor activity
EWH46_10365	COG3181	Tripartite tricarboxylate transporter family receptor
EWH46_10370	COG3976	FMN-binding domain protein
EWH46_10370	COG0431	NADPH-dependent FMN reductase
EWH46_10370	COG1053	succinate dehydrogenase
EWH46_10380	COG4178	(ABC) transporter
EWH46_10385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EWH46_10395	COG2878	Part of a membrane complex involved in electron transport
EWH46_10405	COG0582	viral genome integration into host DNA
EWH46_10515	COG0745	RESPONSE REGULATOR receiver
EWH46_10515	COG2205	protein histidine kinase activity
EWH46_10515	COG4191	Histidine kinase
EWH46_10525	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EWH46_10540	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
EWH46_10550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EWH46_10555	COG0298	carbon dioxide binding
EWH46_10560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EWH46_10565	COG1773	rubredoxin
EWH46_10570	COG1773	rubredoxin
EWH46_10575	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EWH46_10580	COG0375	protein maturation
EWH46_10585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EWH46_10590	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EWH46_10595	COG0298	carbon dioxide binding
EWH46_10600	COG0409	Hydrogenase expression formation protein
EWH46_10605	COG0309	Hydrogenase expression formation protein (HypE)
EWH46_10625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EWH46_10625	COG1199	ATP-dependent helicase activity
EWH46_10635	COG2204	response regulator
EWH46_10640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EWH46_10670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EWH46_10675	COG1960	acyl-CoA dehydrogenase activity
EWH46_10680	COG1960	acyl-CoA dehydrogenase activity
EWH46_10685	COG0183	Belongs to the thiolase family
EWH46_10690	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWH46_10690	COG1024	Enoyl-CoA hydratase
EWH46_10695	COG0583	DNA-binding transcription factor activity
EWH46_10710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWH46_10710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EWH46_10720	COG0400	carboxylic ester hydrolase activity
EWH46_10730	COG0745	RESPONSE REGULATOR receiver
EWH46_10740	COG0840	transmembrane signaling receptor activity
EWH46_10745	COG0835	chemotaxis
EWH46_10750	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EWH46_10755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EWH46_10760	COG0835	chemotaxis
EWH46_10775	COG2226	methyltransferase
EWH46_10775	COG1073	alpha beta
EWH46_10780	COG0840	transmembrane signaling receptor activity
EWH46_10785	COG1295	ribonuclease BN
EWH46_10795	COG0277	FAD linked oxidase domain protein
EWH46_10815	COG1007	ATP synthesis coupled electron transport
EWH46_10830	COG0713	ATP synthesis coupled electron transport
EWH46_10840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EWH46_10845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EWH46_10850	COG1034	ATP synthesis coupled electron transport
EWH46_10860	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EWH46_10865	COG0649	NAD binding
EWH46_10870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EWH46_10875	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EWH46_10880	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EWH46_10890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EWH46_10895	COG0149	triose-phosphate isomerase activity
EWH46_10900	COG0604	alcohol dehydrogenase
EWH46_10900	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_10900	COG3321	synthase
EWH46_10905	COG1185	polyribonucleotide nucleotidyltransferase activity
EWH46_10910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EWH46_10920	COG0683	leucine binding
EWH46_10925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EWH46_10930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EWH46_10985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EWH46_10985	COG4191	Histidine kinase
EWH46_10990	COG0668	transmembrane transport
EWH46_10995	COG0564	pseudouridine synthase activity
EWH46_11005	COG1045	serine acetyltransferase
EWH46_11040	COG0513	Belongs to the DEAD box helicase family
EWH46_11045	COG2205	protein histidine kinase activity
EWH46_11050	COG0745	RESPONSE REGULATOR receiver
EWH46_11060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWH46_11080	COG0438	transferase activity, transferring glycosyl groups
EWH46_11105	COG3275	phosphorelay sensor kinase activity
EWH46_11110	COG0165	Argininosuccinate lyase
EWH46_11125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EWH46_11130	COG2860	membrane
EWH46_11135	COG3945	hemerythrin HHE cation binding domain
EWH46_11150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWH46_11155	COG4968	Prepilin-type N-terminal cleavage methylation domain
EWH46_11190	COG0729	surface antigen
EWH46_11215	COG5001	Diguanylate cyclase
EWH46_11215	COG4251	negative regulation of phosphorylation
EWH46_11215	COG2203	Gaf domain
EWH46_11215	COG3706	GGDEF domain
EWH46_11225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EWH46_11225	COG2885	chlorophyll binding
EWH46_11245	COG0210	DNA helicase
EWH46_11265	COG4969	Belongs to the N-Me-Phe pilin family
EWH46_11335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EWH46_11340	COG1984	allophanate hydrolase subunit 2
EWH46_11345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EWH46_11350	COG1049	propionate catabolic process, 2-methylcitrate cycle
EWH46_11365	COG0039	L-malate dehydrogenase activity
EWH46_11370	COG2188	Transcriptional regulator
EWH46_11385	COG1053	succinate dehydrogenase
EWH46_11390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EWH46_11395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EWH46_11400	COG0372	Belongs to the citrate synthase family
EWH46_11415	COG1191	sigma factor activity
EWH46_11430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EWH46_11435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EWH46_11440	COG2217	Heavy metal translocating P-type atpase
EWH46_11445	COG2160	L-arabinose isomerase activity
EWH46_11460	COG4213	ABC transporter substrate-binding protein
EWH46_11470	COG4214	carbohydrate transport
EWH46_11490	COG5001	Diguanylate cyclase
EWH46_11495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EWH46_11500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EWH46_11505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EWH46_11510	COG0140	phosphoribosyl-ATP diphosphatase activity
EWH46_11520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWH46_11525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EWH46_11530	COG0805	protein transport
EWH46_11535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWH46_11540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EWH46_11550	COG3384	dioxygenase
EWH46_11555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EWH46_11570	COG2223	nitrite transmembrane transporter activity
EWH46_11580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EWH46_11585	COG0243	molybdopterin cofactor binding
EWH46_11590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EWH46_11605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EWH46_11610	COG2124	cytochrome p450
EWH46_11615	COG0156	8-amino-7-oxononanoate synthase activity
EWH46_11625	COG0439	Biotin carboxylase
EWH46_11630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EWH46_11635	COG1703	isobutyryl-CoA mutase activity
EWH46_11650	COG1802	Transcriptional regulator
EWH46_11655	COG0045	succinate-CoA ligase (ADP-forming) activity
EWH46_11660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EWH46_11675	COG1881	PFAM PEBP family protein
EWH46_11705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EWH46_11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
EWH46_11725	COG4566	intracellular signal transduction
EWH46_11730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EWH46_11750	COG0297	glycogen (starch) synthase activity
EWH46_11750	COG0438	transferase activity, transferring glycosyl groups
EWH46_11780	COG0792	nuclease activity
EWH46_11785	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EWH46_11790	COG2823	Periplasmic or secreted lipoprotein
EWH46_11795	COG2084	Dehydrogenase
EWH46_11880	COG0583	DNA-binding transcription factor activity
EWH46_11890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EWH46_11910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EWH46_11920	COG2925	Exonuclease
EWH46_11925	COG1793	dna ligase
EWH46_11940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWH46_11945	COG0308	aminopeptidase N
EWH46_11950	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EWH46_11965	COG1404	Belongs to the peptidase S8 family
EWH46_11970	COG1858	cytochrome C peroxidase
EWH46_11975	COG1858	cytochrome C peroxidase
EWH46_11980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EWH46_11985	COG1074	ATP-dependent DNA helicase activity
EWH46_11990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EWH46_12000	COG1404	Belongs to the peptidase S8 family
EWH46_12010	COG1253	flavin adenine dinucleotide binding
EWH46_12015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EWH46_12030	COG5001	Diguanylate cyclase
EWH46_12030	COG5002	protein histidine kinase activity
EWH46_12030	COG3447	MASE1 domain protein
EWH46_12040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWH46_12080	COG1215	transferase activity, transferring glycosyl groups
EWH46_12085	COG0438	transferase activity, transferring glycosyl groups
EWH46_12120	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EWH46_12140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EWH46_12145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EWH46_12150	COG2755	lipolytic protein G-D-S-L family
EWH46_12150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EWH46_12160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWH46_12165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EWH46_12195	COG0463	Glycosyl transferase, family 2
EWH46_12220	COG0438	transferase activity, transferring glycosyl groups
EWH46_12235	COG1091	dTDP-4-dehydrorhamnose reductase activity
EWH46_12240	COG1088	dTDP-glucose 4,6-dehydratase activity
EWH46_12250	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EWH46_12255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWH46_12270	COG3206	protein involved in exopolysaccharide biosynthesis
EWH46_12270	COG0489	protein tyrosine kinase activity
EWH46_12275	COG4464	protein tyrosine phosphatase activity
EWH46_12290	COG0675	Transposase, IS605 OrfB family
EWH46_12295	COG0004	ammonium transporteR
EWH46_12300	COG0513	Belongs to the DEAD box helicase family
EWH46_12315	COG3022	response to hydroperoxide
EWH46_12330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EWH46_12335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWH46_12340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EWH46_12350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EWH46_12355	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EWH46_12365	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EWH46_12370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EWH46_12375	COG1492	cobalamin metabolic process
EWH46_12380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EWH46_12385	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EWH46_12390	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EWH46_12395	COG1120	ATPase activity
EWH46_12400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EWH46_12405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EWH46_12415	COG4206	TonB-dependent receptor
EWH46_12430	COG0730	response to heat
EWH46_12435	COG0840	transmembrane signaling receptor activity
EWH46_12440	COG0643	Histidine kinase
EWH46_12440	COG2198	Histidine kinase
EWH46_12455	COG2197	response regulator
EWH46_12470	COG0107	imidazoleglycerol-phosphate synthase activity
EWH46_12480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EWH46_12485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EWH46_12490	COG0131	Imidazoleglycerol-phosphate dehydratase
EWH46_12495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EWH46_12505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EWH46_12510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EWH46_12520	COG0842	Transport permease protein
EWH46_12525	COG1131	(ABC) transporter
EWH46_12530	COG0625	glutathione transferase activity
EWH46_12540	COG1652	LysM domain
EWH46_12565	COG0429	hydrolase of the alpha beta-hydrolase fold
EWH46_12580	COG0859	PFAM glycosyl transferase family 9
EWH46_12595	COG0784	Response regulator, receiver
EWH46_12595	COG2205	protein histidine kinase activity
EWH46_12615	COG1215	transferase activity, transferring glycosyl groups
EWH46_12620	COG1215	transferase activity, transferring glycosyl groups
EWH46_12625	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EWH46_12630	COG0457	Tetratricopeptide repeat
EWH46_12640	COG0673	inositol 2-dehydrogenase activity
EWH46_12665	COG0366	Alpha amylase catalytic
EWH46_12680	COG1653	transport
EWH46_12695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EWH46_12720	COG0386	Belongs to the glutathione peroxidase family
EWH46_12735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EWH46_12745	COG0583	DNA-binding transcription factor activity
EWH46_12750	COG0840	transmembrane signaling receptor activity
EWH46_12755	COG0840	transmembrane signaling receptor activity
EWH46_12765	COG0778	Nitroreductase
EWH46_12780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EWH46_12790	COG3540	Alkaline phosphatase
EWH46_12810	COG2096	Adenosyltransferase
EWH46_12820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWH46_12825	COG0312	modulator of DNA gyrase
EWH46_12835	COG2832	Protein of unknown function (DUF454)
EWH46_12845	COG2969	positive regulation of protein catabolic process
EWH46_12850	COG0625	glutathione transferase activity
EWH46_12855	COG2857	Cytochrome c1
EWH46_12860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EWH46_12865	COG0723	plastoquinol--plastocyanin reductase activity
EWH46_12870	COG1970	mechanosensitive ion channel activity
EWH46_12875	COG5001	Diguanylate cyclase
EWH46_12875	COG3300	MHYT domain
EWH46_12880	COG1448	Aminotransferase
EWH46_12895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EWH46_12905	COG1607	acyl-coa hydrolase
EWH46_12940	COG3123	guanosine phosphorylase activity
EWH46_12945	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_12955	COG0515	serine threonine protein kinase
EWH46_12955	COG2815	serine threonine protein kinase
EWH46_12980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EWH46_12985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EWH46_13040	COG0181	hydroxymethylbilane synthase activity
EWH46_13045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EWH46_13060	COG2944	sequence-specific DNA binding
EWH46_13085	COG0411	ABC transporter
EWH46_13100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EWH46_13105	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EWH46_13125	COG0492	ferredoxin-NADP+ reductase activity
EWH46_13130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EWH46_13135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EWH46_13150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EWH46_13150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EWH46_13155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EWH46_13160	COG3753	Protein conserved in bacteria
EWH46_13170	COG2205	protein histidine kinase activity
EWH46_13195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EWH46_13200	COG1758	RNA polymerase activity
EWH46_13205	COG0194	GDP metabolic process
EWH46_13210	COG1561	YicC-like family, N-terminal region
EWH46_13225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EWH46_13230	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EWH46_13235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EWH46_13240	COG2201	protein-glutamate methylesterase activity
EWH46_13245	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EWH46_13250	COG3706	GGDEF domain
EWH46_13255	COG0455	bacterial-type flagellum organization
EWH46_13265	COG2840	Smr protein MutS2
EWH46_13270	COG2003	Belongs to the UPF0758 family
EWH46_13275	COG1047	Peptidyl-prolyl cis-trans
EWH46_13280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EWH46_13285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EWH46_13355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EWH46_13395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EWH46_13400	COG0633	Ferredoxin
EWH46_13405	COG0443	Heat shock 70 kDa protein
EWH46_13410	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EWH46_13420	COG0822	iron-sulfur transferase activity
EWH46_13425	COG1104	cysteine desulfurase activity
EWH46_13430	COG1959	2 iron, 2 sulfur cluster binding
EWH46_13435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWH46_13475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EWH46_13485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EWH46_13505	COG1987	bacterial-type flagellum assembly
EWH46_13520	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EWH46_13555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EWH46_13560	COG1766	The M ring may be actively involved in energy transduction
EWH46_13565	COG1677	Flagellar hook-basal body complex protein FliE
EWH46_13570	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EWH46_13590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EWH46_13635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EWH46_13645	COG0745	RESPONSE REGULATOR receiver
EWH46_13665	COG0243	molybdopterin cofactor binding
EWH46_13670	COG1473	amidohydrolase
EWH46_13685	COG0166	Belongs to the GPI family
EWH46_13690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EWH46_13700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EWH46_13705	COG1737	Transcriptional regulator
EWH46_13705	COG0837	glucose binding
EWH46_13725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EWH46_13730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EWH46_13735	COG1127	ABC transporter
EWH46_13750	COG0067	glutamate synthase
EWH46_13750	COG0069	glutamate synthase activity
EWH46_13750	COG0070	glutamate synthase
EWH46_13790	COG1595	DNA-templated transcription, initiation
EWH46_13795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EWH46_13800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EWH46_13840	COG1965	Belongs to the frataxin family
EWH46_13865	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EWH46_13880	COG1765	OsmC-like protein
EWH46_13885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EWH46_13890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EWH46_13905	COG2165	general secretion pathway protein
EWH46_13955	COG5001	Diguanylate cyclase
EWH46_13960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EWH46_13970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWH46_14020	COG4942	peptidase
EWH46_14025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EWH46_14030	COG0316	Belongs to the HesB IscA family
EWH46_14045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EWH46_14050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EWH46_14060	COG5433	transposase activity
EWH46_14095	COG0402	S-adenosylhomocysteine deaminase activity
EWH46_14110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EWH46_14120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWH46_14125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EWH46_14130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EWH46_14145	COG0438	transferase activity, transferring glycosyl groups
EWH46_14170	COG2244	polysaccharide biosynthetic process
EWH46_14175	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EWH46_14180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWH46_14200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EWH46_14205	COG1091	dTDP-4-dehydrorhamnose reductase activity
EWH46_14210	COG1088	dTDP-glucose 4,6-dehydratase activity
EWH46_14220	COG0513	Belongs to the DEAD box helicase family
EWH46_14225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EWH46_14230	COG0424	maF-like protein
EWH46_14240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EWH46_14245	COG0416	fatty acid biosynthetic process
EWH46_14250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EWH46_14255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EWH46_14265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EWH46_14270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EWH46_14295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EWH46_14300	COG0481	GTPase activity
EWH46_14315	COG0571	ribonuclease III activity
EWH46_14320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EWH46_14325	COG1381	Involved in DNA repair and RecF pathway recombination
EWH46_14330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EWH46_14335	COG0736	holo-[acyl-carrier-protein] synthase activity
EWH46_14340	COG1472	Belongs to the glycosyl hydrolase 3 family
EWH46_14350	COG0512	Glutamine amidotransferase of anthranilate synthase
EWH46_14350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EWH46_14355	COG1530	ribonuclease E activity
EWH46_14375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EWH46_14375	COG0616	signal peptide processing
EWH46_14380	COG0019	diaminopimelate decarboxylase activity
EWH46_14385	COG0583	DNA-binding transcription factor activity
EWH46_14400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EWH46_14410	COG0840	transmembrane signaling receptor activity
EWH46_14420	COG0583	DNA-binding transcription factor activity
EWH46_14435	COG0463	Glycosyl transferase, family 2
EWH46_14435	COG0457	Tetratricopeptide repeat
EWH46_14445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EWH46_14450	COG0237	dephospho-CoA kinase activity
EWH46_14455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EWH46_14460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EWH46_14465	COG0494	nUDIX hydrolase
EWH46_14475	COG1309	transcriptional regulator
EWH46_14485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EWH46_14505	COG2132	Multicopper oxidase
EWH46_14535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWH46_14540	COG3162	membrane
EWH46_14545	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EWH46_14550	COG4191	Histidine kinase
EWH46_14560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EWH46_14580	COG0437	4 iron, 4 sulfur cluster binding
EWH46_14585	COG3383	formate dehydrogenase (NAD+) activity
EWH46_14585	COG0243	molybdopterin cofactor binding
EWH46_14615	COG0746	molybdenum cofactor guanylyltransferase activity
EWH46_14630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EWH46_14635	COG0138	bifunctional purine biosynthesis protein purh
EWH46_14640	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EWH46_14650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EWH46_14670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EWH46_14675	COG3844	kynureninase activity
EWH46_14680	COG3483	tryptophan 2,3-dioxygenase activity
EWH46_14700	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EWH46_14715	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EWH46_14720	COG1181	Belongs to the D-alanine--D-alanine ligase family
EWH46_14725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EWH46_14730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EWH46_14745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EWH46_14750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EWH46_14755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EWH46_14770	COG0275	rRNA processing
EWH46_14780	COG0443	Heat shock 70 kDa protein
EWH46_14785	COG3181	Tripartite tricarboxylate transporter family receptor
EWH46_14790	COG0154	amidase activity
EWH46_14795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EWH46_14800	COG1077	Cell shape determining protein MreB Mrl
EWH46_14815	COG0768	penicillin binding
EWH46_14820	COG0772	Belongs to the SEDS family
EWH46_14825	COG0642	Histidine kinase
EWH46_14835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EWH46_14840	COG2137	regulation of response to DNA damage stimulus
EWH46_14845	COG0045	succinate-CoA ligase (ADP-forming) activity
EWH46_14850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EWH46_14855	COG0861	Integral membrane protein TerC family
EWH46_14860	COG1950	PFAM Membrane protein of
EWH46_14865	COG4783	chaperone-mediated protein folding
EWH46_14870	COG0315	cyclic pyranopterin monophosphate synthase activity
EWH46_14875	COG3307	-O-antigen
EWH46_14885	COG4969	Belongs to the N-Me-Phe pilin family
EWH46_14890	COG0459	protein refolding
EWH46_14895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EWH46_14925	COG1960	acyl-CoA dehydrogenase activity
EWH46_14935	COG1024	Enoyl-CoA hydratase
EWH46_14935	COG1250	3-hydroxyacyl-CoA dehydrogenase
EWH46_14940	COG0183	Belongs to the thiolase family
EWH46_14945	COG1024	Enoyl-CoA hydratase
EWH46_14955	COG1607	acyl-coa hydrolase
EWH46_14960	COG5265	(ABC) transporter
EWH46_14970	COG0583	DNA-binding transcription factor activity
EWH46_14975	COG0418	dihydroorotase activity
EWH46_14980	COG0501	Belongs to the peptidase M48B family
EWH46_14985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EWH46_14995	COG0494	nUDIX hydrolase
EWH46_15010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EWH46_15025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EWH46_15035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EWH46_15040	COG0469	pyruvate kinase activity
EWH46_15040	COG0469	pyruvate kinase activity
EWH46_15050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EWH46_15055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EWH46_15080	COG5000	phosphorelay sensor kinase activity
EWH46_15085	COG2204	response regulator
EWH46_15110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EWH46_15115	COG0668	transmembrane transport
EWH46_15120	COG0840	transmembrane signaling receptor activity
EWH46_15140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EWH46_15160	COG1139	Iron-sulfur cluster binding protein
EWH46_15175	COG2186	Transcriptional regulator
EWH46_15190	COG0588	phosphoglycerate mutase activity
EWH46_15195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EWH46_15200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EWH46_15205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EWH46_15215	COG2226	methyltransferase
EWH46_15230	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EWH46_15260	COG1612	heme a metabolic process
EWH46_15265	COG0109	protoheme IX farnesyltransferase activity
EWH46_15270	COG1999	signal sequence binding
EWH46_15275	COG0191	fructose-bisphosphate aldolase activity
EWH46_15280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EWH46_15285	COG0546	phosphoglycolate phosphatase activity
EWH46_15290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EWH46_15295	COG3954	Phosphoribulokinase
EWH46_15300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EWH46_15305	COG0464	growth
EWH46_15310	COG4451	ribulose bisphosphate carboxylase, small
EWH46_15315	COG1850	ribulose-bisphosphate carboxylase activity
EWH46_15320	COG0583	DNA-binding transcription factor activity
EWH46_15325	COG0840	transmembrane signaling receptor activity
EWH46_15355	COG0517	IMP dehydrogenase activity
EWH46_15355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EWH46_15370	COG1304	FMN binding
EWH46_15375	COG1304	FMN binding
EWH46_15380	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EWH46_15385	COG0049	tRNA binding
EWH46_15390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EWH46_15395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EWH46_15400	COG0051	transcription antitermination factor activity, RNA binding
EWH46_15410	COG2814	Major facilitator Superfamily
EWH46_15435	COG3706	GGDEF domain
EWH46_15450	COG0203	ribosomal protein L17
EWH46_15455	COG0202	RNA polymerase activity
EWH46_15460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EWH46_15465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EWH46_15470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EWH46_15475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EWH46_15485	COG0201	protein transport
EWH46_15490	COG0200	Binds to the 23S rRNA
EWH46_15495	COG1841	ribosomal large subunit assembly
EWH46_15500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EWH46_15505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EWH46_15510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EWH46_15515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EWH46_15520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EWH46_15525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EWH46_15530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EWH46_15535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EWH46_15545	COG0004	ammonium transporteR
EWH46_15560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EWH46_15565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EWH46_15580	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EWH46_15585	COG2329	Antibiotic biosynthesis monooxygenase
EWH46_15590	COG4681	YaeQ
EWH46_15595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EWH46_15605	COG4989	oxidoreductase activity
EWH46_15610	COG3706	GGDEF domain
EWH46_15620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EWH46_15645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EWH46_15655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWH46_15660	COG4783	chaperone-mediated protein folding
EWH46_15665	COG2223	nitrite transmembrane transporter activity
EWH46_15670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EWH46_15675	COG3118	belongs to the thioredoxin family
EWH46_15690	COG0840	transmembrane signaling receptor activity
EWH46_15695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EWH46_15695	COG1372	Participates in initiation and elongation during chromosome replication
EWH46_15710	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_15715	COG3781	membrane
EWH46_15720	COG4953	penicillin-binding protein 1C
EWH46_15745	COG5001	Diguanylate cyclase
EWH46_15745	COG5002	protein histidine kinase activity
EWH46_15750	COG0535	radical SAM domain protein
EWH46_15765	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EWH46_15770	COG3850	Histidine kinase
EWH46_15775	COG2197	response regulator
EWH46_15795	COG2176	DNA-directed DNA polymerase activity
EWH46_15795	COG5002	protein histidine kinase activity
EWH46_15800	COG0745	RESPONSE REGULATOR receiver
EWH46_15805	COG5002	protein histidine kinase activity
EWH46_15820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EWH46_15850	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EWH46_15850	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EWH46_15860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EWH46_15865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EWH46_15905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EWH46_15910	COG0752	glycyl-tRNA synthetase alpha subunit
EWH46_15915	COG0751	glycine-tRNA ligase activity
EWH46_15920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EWH46_15925	COG0204	Acyl-transferase
EWH46_15935	COG2814	Major facilitator Superfamily
EWH46_15940	COG2070	2-Nitropropane dioxygenase
EWH46_15945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EWH46_15955	COG3842	ATPase activity
EWH46_15965	COG1176	ABC-type spermidine putrescine transport system, permease component I
EWH46_15970	COG3833	ABC-type maltose transport systems, permease component
EWH46_15975	COG1802	Transcriptional regulator
EWH46_15985	COG0277	FAD linked oxidase domain protein
EWH46_15990	COG2719	SpoVR family
EWH46_15995	COG2718	Belongs to the UPF0229 family
EWH46_16000	COG2766	serine protein kinase
EWH46_16015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EWH46_16040	COG0631	protein serine/threonine phosphatase activity
EWH46_16050	COG1234	tRNA 3'-trailer cleavage
EWH46_16055	COG0730	response to heat
EWH46_16065	COG2095	MarC family integral membrane protein
EWH46_16070	COG0724	RNA recognition motif
EWH46_16075	COG4221	oxidoreductase activity
EWH46_16105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EWH46_16110	COG0706	membrane insertase activity
EWH46_16115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EWH46_16125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EWH46_16130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EWH46_16145	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EWH46_16150	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EWH46_16185	COG3454	Phosphonate metabolism
EWH46_16200	COG1597	lipid kinase activity
EWH46_16205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EWH46_16210	COG3459	Glycosyltransferase 36 associated
EWH46_16235	COG2197	response regulator
EWH46_16240	COG0189	ligase activity
EWH46_16245	COG3135	benzoate transporter
EWH46_16255	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EWH46_16260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EWH46_16265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EWH46_16285	COG0281	malic enzyme
EWH46_16285	COG0280	phosphate acetyltransferase
EWH46_16305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EWH46_16310	COG1058	Belongs to the CinA family
EWH46_16310	COG1546	Belongs to the CinA family
EWH46_16340	COG0495	leucyl-tRNA aminoacylation
EWH46_16360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EWH46_16365	COG0735	belongs to the Fur family
EWH46_16370	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EWH46_16380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EWH46_16395	COG4221	oxidoreductase activity
EWH46_16415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EWH46_16440	COG3038	cytochrome b561
EWH46_16460	COG1902	pentaerythritol trinitrate reductase activity
EWH46_16470	COG3008	intermembrane lipid transfer
EWH46_16470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EWH46_16475	COG1127	ABC transporter
EWH46_16480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EWH46_16500	COG2823	Periplasmic or secreted lipoprotein
EWH46_16505	COG1295	ribonuclease BN
EWH46_16520	COG4178	(ABC) transporter
EWH46_16525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EWH46_16530	COG0321	lipoyl(octanoyl) transferase activity
EWH46_16550	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EWH46_16555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EWH46_16565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWH46_16570	COG1333	cytochrome c biogenesis protein
EWH46_16580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EWH46_16590	COG1752	Esterase of the alpha-beta hydrolase superfamily
EWH46_16605	COG0644	oxidoreductase
EWH46_16610	COG3300	MHYT domain
EWH46_16610	COG5001	Diguanylate cyclase
EWH46_16620	COG0121	glutamine amidotransferase
EWH46_16635	COG4172	Belongs to the ABC transporter superfamily
EWH46_16645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWH46_16695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EWH46_16710	COG0598	Magnesium transport protein CorA
EWH46_16715	COG1573	uracil-dna glycosylase
EWH46_16725	COG1214	PFAM Peptidase M22, glycoprotease
EWH46_16745	COG0009	L-threonylcarbamoyladenylate synthase
EWH46_16750	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EWH46_16770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EWH46_16780	COG0469	pyruvate kinase activity
EWH46_16785	COG0281	malic enzyme
EWH46_16785	COG0280	phosphate acetyltransferase
EWH46_16790	COG0126	phosphoglycerate kinase activity
EWH46_16810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EWH46_16815	COG0242	peptide deformylase activity
EWH46_16825	COG0758	DNA mediated transformation
EWH46_16830	COG2922	Belongs to the Smg family
EWH46_16840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWH46_16845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EWH46_16850	COG1862	Preprotein translocase
EWH46_16855	COG2199	diguanylate cyclase activity
EWH46_16855	COG2200	EAL domain
EWH46_16855	COG2202	Pas domain
EWH46_16860	COG1404	Belongs to the peptidase S8 family
EWH46_16865	COG0210	DNA helicase
EWH46_16870	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EWH46_16875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EWH46_16885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EWH46_16890	COG1122	ATPase activity
EWH46_16900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EWH46_16905	COG1522	sequence-specific DNA binding
EWH46_16915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EWH46_16930	COG0037	tRNA processing
EWH46_16955	COG0617	tRNA 3'-terminal CCA addition
EWH46_16970	COG1196	nuclear chromosome segregation
EWH46_16970	COG0741	lytic transglycosylase activity
EWH46_16970	COG0739	heme binding
EWH46_16980	COG3047	cAMP biosynthetic process
EWH46_16990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EWH46_16995	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EWH46_17020	COG2921	Belongs to the UPF0250 family
EWH46_17025	COG1686	Belongs to the peptidase S11 family
EWH46_17030	COG2945	thiolester hydrolase activity
EWH46_17050	COG0515	serine threonine protein kinase
EWH46_17050	COG2815	serine threonine protein kinase
EWH46_17055	COG0018	arginyl-trna synthetase
EWH46_17065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWH46_17075	COG1137	ATPase activity
EWH46_17080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EWH46_17095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EWH46_17120	COG0489	protein tyrosine kinase activity
EWH46_17120	COG3206	protein involved in exopolysaccharide biosynthesis
EWH46_17130	COG1215	transferase activity, transferring glycosyl groups
EWH46_17165	COG0840	transmembrane signaling receptor activity
EWH46_17205	COG0346	lactoylglutathione lyase activity
EWH46_17225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EWH46_17240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EWH46_17265	COG1175	transmembrane transport
EWH46_17270	COG0395	ABC-type sugar transport system, permease component
EWH46_17285	COG0246	Mannitol dehydrogenase
EWH46_17290	COG2207	Transcriptional regulator
EWH46_17295	COG1070	Carbohydrate kinase
EWH46_17310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EWH46_17325	COG1560	Kdo2-lipid A biosynthetic process
EWH46_17335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EWH46_17340	COG0840	transmembrane signaling receptor activity
EWH46_17355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EWH46_17360	COG2326	polyphosphate kinase activity
EWH46_17365	COG1522	sequence-specific DNA binding
EWH46_17375	COG0318	PFAM AMP-dependent synthetase and ligase
EWH46_17390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EWH46_17390	COG0045	succinate-CoA ligase (ADP-forming) activity
EWH46_17390	COG1042	CoA-binding domain protein
EWH46_17415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EWH46_17425	COG0564	pseudouridine synthase activity
EWH46_17450	COG2321	neutral zinc metallopeptidase
EWH46_17455	COG0583	DNA-binding transcription factor activity
EWH46_17480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EWH46_17485	COG2814	Major facilitator Superfamily
EWH46_17500	COG3237	CsbD-like
EWH46_17515	COG0116	Belongs to the methyltransferase superfamily
EWH46_17515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EWH46_17535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EWH46_17540	COG1609	Transcriptional regulator
EWH46_17545	COG4213	ABC transporter substrate-binding protein
EWH46_17550	COG4214	carbohydrate transport
EWH46_17560	COG1070	Carbohydrate kinase
EWH46_17585	COG0693	protein deglycase activity
EWH46_17600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EWH46_17615	COG5001	Diguanylate cyclase
EWH46_17615	COG5002	protein histidine kinase activity
EWH46_17620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EWH46_17635	COG1522	sequence-specific DNA binding
EWH46_17640	COG1609	Transcriptional regulator
EWH46_17645	COG3265	gluconokinase activity
EWH46_17650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EWH46_17655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EWH46_17660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EWH46_17680	COG1192	Involved in chromosome partitioning
EWH46_17685	COG1280	lysine exporter protein (LysE YggA)
EWH46_17690	COG0357	Ribosomal RNA small subunit methyltransferase G
EWH46_17695	COG0445	tRNA wobble uridine modification
EWH46_17720	COG2207	Transcriptional regulator
EWH46_17725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EWH46_17740	COG0584	glycerophosphoryl diester phosphodiesterase
EWH46_17750	COG1280	lysine exporter protein (LysE YggA)
EWH46_17780	COG2423	ornithine cyclodeaminase activity
EWH46_17790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EWH46_17800	COG0745	RESPONSE REGULATOR receiver
EWH46_17805	COG2194	sulfuric ester hydrolase activity
EWH46_17830	COG2040	homocysteine
EWH46_17840	COG1522	sequence-specific DNA binding
EWH46_17845	COG0667	Aldo Keto reductase
EWH46_17855	COG0210	DNA helicase
EWH46_17860	COG0517	IMP dehydrogenase activity
EWH46_17870	COG0473	3-isopropylmalate dehydrogenase activity
EWH46_17875	COG4651	solute:proton antiporter activity
EWH46_17875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EWH46_17915	COG0569	domain protein
EWH46_17935	COG0438	transferase activity, transferring glycosyl groups
EWH46_17945	COG1960	acyl-CoA dehydrogenase activity
EWH46_17950	COG1280	lysine exporter protein (LysE YggA)
EWH46_17955	COG0183	Belongs to the thiolase family
EWH46_17960	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EWH46_17965	COG0288	reversible hydration of carbon dioxide
EWH46_17970	COG1760	l-serine dehydratase
EWH46_17980	COG3284	Transcriptional regulator
EWH46_17995	COG0436	Aminotransferase
EWH46_18005	COG2223	nitrite transmembrane transporter activity
EWH46_18035	COG3550	peptidyl-serine autophosphorylation
EWH46_18050	COG1132	(ABC) transporter
EWH46_18165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EWH46_18170	COG4804	nuclease activity
EWH46_18210	COG4372	Transposase
EWH46_18255	COG4974	Belongs to the 'phage' integrase family
EWH46_18340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWH46_18345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EWH46_18365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EWH46_18375	COG1999	signal sequence binding
EWH46_18395	COG1742	UPF0060 membrane protein
EWH46_18410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EWH46_18460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EWH46_18540	COG5433	transposase activity
EWH46_18550	COG0840	transmembrane signaling receptor activity
EWH46_18555	COG3718	enzyme involved in inositol metabolism
EWH46_18565	COG3962	Belongs to the TPP enzyme family
EWH46_18570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EWH46_18585	COG1172	Belongs to the binding-protein-dependent transport system permease family
EWH46_18595	COG0840	transmembrane signaling receptor activity
EWH46_18600	COG0745	RESPONSE REGULATOR receiver
EWH46_18610	COG2198	Histidine kinase
EWH46_18610	COG0643	Histidine kinase
EWH46_18620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EWH46_18630	COG2201	protein-glutamate methylesterase activity
EWH46_18635	COG0835	chemotaxis
EWH46_18645	COG1797	cobyrinic acid a,c-diamide synthase activity
EWH46_18670	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EWH46_18700	COG3411	Ferredoxin
EWH46_18710	COG0431	NADPH-dependent FMN reductase
EWH46_18715	COG0612	Peptidase, M16
EWH46_18725	COG2159	amidohydrolase
EWH46_18735	COG3339	Conserved Protein
EWH46_18745	COG0243	molybdopterin cofactor binding
EWH46_18750	COG0437	4 iron, 4 sulfur cluster binding
EWH46_18755	COG0348	domain, Protein
EWH46_18765	COG3005	denitrification pathway
EWH46_18775	COG2010	Cytochrome c
EWH46_18780	COG3256	nitric oxide reductase
EWH46_18800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EWH46_18805	COG4133	protoheme IX ABC transporter activity
EWH46_18815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EWH46_18825	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EWH46_18830	COG1138	Cytochrome C-type biogenesis protein
EWH46_18840	COG3088	subunit of a heme lyase
EWH46_18855	COG0778	Nitroreductase
EWH46_18895	COG3851	Histidine kinase
EWH46_18900	COG2197	response regulator
EWH46_18925	COG1192	Involved in chromosome partitioning
EWH46_18930	COG1475	DNA binding
EWH46_18935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EWH46_18940	COG0179	Fumarylacetoacetate (FAA) hydrolase
EWH46_19025	COG4771	TonB-dependent receptor
EWH46_19025	COG1629	transport
EWH46_19030	COG3720	iron ion transport
EWH46_19035	COG4558	Periplasmic binding protein
EWH46_19045	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EWH46_19060	COG0513	Belongs to the DEAD box helicase family
EWH46_19065	COG0210	DNA helicase
EWH46_19080	COG0395	ABC-type sugar transport system, permease component
EWH46_19090	COG3842	ATPase activity
EWH46_19095	COG3842	ATPase activity
EWH46_19110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EWH46_19155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EWH46_19170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EWH46_19185	COG2205	protein histidine kinase activity
EWH46_19190	COG0745	RESPONSE REGULATOR receiver
EWH46_19195	COG2721	sulfolactate sulfo-lyase activity
EWH46_19200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EWH46_19210	COG4948	Mandelate Racemase Muconate Lactonizing
EWH46_19225	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EWH46_19235	COG3048	D-serine ammonia-lyase activity
EWH46_19310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EWH46_19315	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EWH46_19355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EWH46_19360	COG2181	nitrate reductase activity
EWH46_19360	COG0247	lactate metabolic process
EWH46_19365	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWH46_19365	COG1902	pentaerythritol trinitrate reductase activity
EWH46_19385	COG4638	Rieske (2fe-2S)
EWH46_19395	COG4175	Glycine betaine
EWH46_19400	COG4176	ABC-type proline glycine betaine transport system permease component
EWH46_19425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EWH46_19435	COG2113	Glycine betaine
EWH46_19450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EWH46_19450	COG0446	pyridine nucleotide-disulphide oxidoreductase
EWH46_19470	COG1760	l-serine dehydratase
EWH46_19480	COG0697	spore germination
EWH46_19485	COG2207	Transcriptional regulator
EWH46_19495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EWH46_19510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EWH46_19515	COG3639	organic phosphonate transmembrane transporter activity
EWH46_19520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EWH46_19520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EWH46_19525	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EWH46_19530	COG0412	Dienelactone hydrolase
EWH46_19535	COG1024	Enoyl-CoA hydratase
EWH46_19540	COG1024	Enoyl-CoA hydratase
EWH46_19565	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_19570	COG3181	Tripartite tricarboxylate transporter family receptor
EWH46_19580	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EWH46_19595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EWH46_19600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWH46_19605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EWH46_19615	COG2390	Transcriptional regulator
EWH46_19620	COG0698	ribose 5-phosphate isomerase
EWH46_19625	COG2376	Dihydroxyacetone kinase
EWH46_19635	COG0583	DNA-binding transcription factor activity
EWH46_19640	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_19645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EWH46_19655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EWH46_19665	COG3959	Transketolase, thiamine diphosphate binding domain
EWH46_19670	COG3958	Transketolase
EWH46_19680	COG1695	Transcriptional regulator
EWH46_19685	COG4974	Belongs to the 'phage' integrase family
EWH46_19700	COG1454	alcohol dehydrogenase
EWH46_19720	COG0564	pseudouridine synthase activity
EWH46_19725	COG1082	Xylose isomerase domain protein TIM barrel
EWH46_19730	COG0673	inositol 2-dehydrogenase activity
EWH46_19735	COG0673	inositol 2-dehydrogenase activity
EWH46_19745	COG1609	Transcriptional regulator
EWH46_19755	COG1609	Transcriptional regulator
EWH46_19765	COG0673	inositol 2-dehydrogenase activity
EWH46_19770	COG0673	inositol 2-dehydrogenase activity
EWH46_19780	COG1028	Short-chain dehydrogenase reductase Sdr
EWH46_19785	COG0277	FAD linked oxidase domain protein
EWH46_19790	COG0702	epimerase
EWH46_19795	COG1733	regulation of RNA biosynthetic process
EWH46_19825	COG0667	Aldo Keto reductase
EWH46_19830	COG1742	UPF0060 membrane protein
EWH46_19835	COG0129	dihydroxy-acid dehydratase activity
EWH46_19870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EWH46_19890	COG1609	Transcriptional regulator
EWH46_19895	COG2188	Transcriptional regulator
EWH46_19905	COG2847	Copper chaperone PCu(A)C
EWH46_19945	COG5001	Diguanylate cyclase