locus-tag	class	description
K663_00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K663_00010	COG0424	maF-like protein
K663_00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K663_00020	COG0237	dephospho-CoA kinase activity
K663_00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K663_00030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K663_00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K663_00065	COG1999	signal sequence binding
K663_00070	COG2983	Belongs to the UPF0260 family
K663_00095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K663_00115	COG0495	leucyl-tRNA aminoacylation
K663_00130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K663_00145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K663_00150	COG0861	Integral membrane protein TerC family
K663_00170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K663_00175	COG0445	tRNA wobble uridine modification
K663_00180	COG0357	Ribosomal RNA small subunit methyltransferase G
K663_00185	COG1192	Involved in chromosome partitioning
K663_00190	COG1475	DNA binding
K663_00195	COG0308	aminopeptidase N
K663_00210	COG1127	ABC transporter
K663_00215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K663_00225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K663_00235	COG1201	RNA secondary structure unwinding
K663_00260	COG0187	DNA topoisomerase II activity
K663_00270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K663_00275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K663_00285	COG0124	histidyl-tRNA synthetase
K663_00290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K663_00295	COG2890	protein-(glutamine-N5) methyltransferase activity
K663_00310	COG1607	acyl-coa hydrolase
K663_00320	COG0517	IMP dehydrogenase activity
K663_00320	COG1125	glycine betaine transport
K663_00335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K663_00345	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K663_00355	COG0531	amino acid
K663_00360	COG2814	Major facilitator Superfamily
K663_00395	COG0784	Response regulator, receiver
K663_00405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K663_00420	COG0783	Belongs to the Dps family
K663_00425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K663_00455	COG1741	Belongs to the pirin family
K663_00465	COG2884	Cell division ATP-binding protein ftsE
K663_00485	COG0287	Prephenate dehydrogenase
K663_00490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K663_00495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K663_00500	COG2813	Specifically methylates the guanine in position
K663_00500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K663_00510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K663_00520	COG0072	phenylalanine-tRNA ligase activity
K663_00525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K663_00535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K663_00540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K663_00575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K663_00595	COG0181	hydroxymethylbilane synthase activity
K663_00600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K663_00605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K663_00615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K663_00630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K663_00635	COG4152	abc transporter atp-binding protein
K663_00645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K663_00670	COG0138	bifunctional purine biosynthesis protein purh
K663_00680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K663_00695	COG0501	Belongs to the peptidase M48B family
K663_00715	COG0629	single-stranded DNA binding
K663_00745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K663_00745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K663_00755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K663_00755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K663_00760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K663_00765	COG1902	pentaerythritol trinitrate reductase activity
K663_00770	COG2733	membrane
K663_00785	COG2261	transglycosylase associated protein
K663_00790	COG2261	transglycosylase associated protein
K663_00805	COG0482	sulfurtransferase activity
K663_00810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K663_00815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K663_00820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K663_00825	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K663_00830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
K663_00845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K663_00850	COG3590	peptidase
K663_00860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K663_00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K663_00870	COG0424	maF-like protein
K663_00880	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K663_00885	COG0582	viral genome integration into host DNA
K663_00935	COG4221	oxidoreductase activity
K663_00950	COG1968	undecaprenyl-diphosphatase activity
K663_00975	COG0246	Mannitol dehydrogenase
K663_00980	COG1904	glucuronate isomerase
K663_00985	COG2271	Major facilitator Superfamily
K663_00990	COG4948	Mandelate Racemase Muconate Lactonizing
K663_01005	COG3661	Belongs to the glycosyl hydrolase 67 family
K663_01020	COG0477	Major facilitator Superfamily
K663_01050	COG0129	dihydroxy-acid dehydratase activity
K663_01100	COG3118	belongs to the thioredoxin family
K663_01105	COG0450	alkyl hydroperoxide reductase
K663_01110	COG0640	Transcriptional regulator
K663_01115	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K663_01120	COG4988	ABC transporter
K663_01125	COG1271	oxidase subunit
K663_01130	COG1294	oxidase, subunit
K663_01140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K663_01145	COG0783	Belongs to the Dps family
K663_01160	COG0640	Transcriptional regulator
K663_01180	COG0446	pyridine nucleotide-disulphide oxidoreductase
K663_01195	COG2080	2 iron, 2 sulfur cluster binding
K663_01200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K663_01205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K663_01225	COG0006	proline dipeptidase activity
K663_01250	COG5265	(ABC) transporter
K663_01255	COG2171	N-acyltransferase activity
K663_01265	COG1611	Belongs to the LOG family
K663_01275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K663_01280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K663_01285	COG2852	Protein conserved in bacteria
K663_01290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K663_01295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K663_01310	COG1301	dicarboxylic acid transport
K663_01315	COG1301	dicarboxylic acid transport
K663_01320	COG0259	pyridoxamine-phosphate oxidase activity
K663_01325	COG0484	heat shock protein binding
K663_01330	COG1295	ribonuclease BN
K663_01335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K663_01350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K663_01370	COG0514	ATP-dependent DNA helicase (RecQ)
K663_01380	COG2081	HI0933 family
K663_01385	COG1230	cation diffusion facilitator family transporter
K663_01415	COG0004	ammonium transporteR
K663_01430	COG0312	modulator of DNA gyrase
K663_01460	COG4695	Portal protein
K663_01660	COG3750	Belongs to the UPF0335 family
K663_01685	COG0582	viral genome integration into host DNA
K663_01700	COG1573	uracil-dna glycosylase
K663_01720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K663_01725	COG0545	Peptidyl-prolyl cis-trans isomerase
K663_01730	COG0628	permease
K663_01735	COG0681	Belongs to the peptidase S26 family
K663_01740	COG0736	holo-[acyl-carrier-protein] synthase activity
K663_01745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K663_01750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K663_01760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K663_01765	COG0109	protoheme IX farnesyltransferase activity
K663_01775	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K663_01805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K663_01810	COG0799	negative regulation of ribosome biogenesis
K663_01815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K663_01825	COG0626	cystathionine gamma-synthase activity
K663_01830	COG2897	thiosulfate sulfurtransferase activity
K663_01840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K663_01860	COG1297	OPT oligopeptide transporter protein
K663_01875	COG0582	viral genome integration into host DNA
K663_01965	COG1401	restriction endodeoxyribonuclease activity
K663_01975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K663_01985	COG4584	PFAM Integrase catalytic
K663_01990	COG1484	DNA-dependent DNA replication
K663_02000	COG0420	3'-5' exonuclease activity
K663_02085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K663_02110	COG1074	ATP-dependent DNA helicase activity
K663_02290	COG1201	RNA secondary structure unwinding
K663_02320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K663_02340	COG4771	TonB-dependent receptor
K663_02350	COG1012	belongs to the aldehyde dehydrogenase family
K663_02360	COG1028	Short-chain dehydrogenase reductase Sdr
K663_02365	COG2124	cytochrome p450
K663_02375	COG1028	Short-chain dehydrogenase reductase Sdr
K663_02385	COG1028	Short-chain dehydrogenase reductase Sdr
K663_02390	COG1028	Short-chain dehydrogenase reductase Sdr
K663_02400	COG3976	FMN-binding domain protein
K663_02400	COG1053	succinate dehydrogenase
K663_02405	COG0583	DNA-binding transcription factor activity
K663_02450	COG0625	glutathione transferase activity
K663_02460	COG4771	TonB-dependent receptor
K663_02500	COG4771	TonB-dependent receptor
K663_02525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K663_02545	COG0412	Dienelactone hydrolase
K663_02550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K663_02560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K663_02595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K663_02600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K663_02635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K663_02635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K663_02645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K663_02645	COG1372	Participates in initiation and elongation during chromosome replication
K663_02670	COG1393	Belongs to the ArsC family
K663_02675	COG1959	2 iron, 2 sulfur cluster binding
K663_02680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K663_02690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K663_02695	COG0416	fatty acid biosynthetic process
K663_02700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K663_02705	COG0776	regulation of translation
K663_02725	COG1199	ATP-dependent helicase activity
K663_02725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K663_02730	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K663_02755	COG4251	negative regulation of phosphorylation
K663_02760	COG3384	dioxygenase
K663_02775	COG0436	Aminotransferase
K663_02780	COG3243	poly(R)-hydroxyalkanoic acid synthase
K663_02790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K663_02795	COG3706	GGDEF domain
K663_02805	COG1494	fructose-1,6-bisphosphatase
K663_02850	COG1132	(ABC) transporter
K663_02860	COG4948	Mandelate Racemase Muconate Lactonizing
K663_02895	COG0297	glycogen (starch) synthase activity
K663_02915	COG2932	Transcriptional regulator
K663_02925	COG2879	small protein
K663_02930	COG1966	Carbon starvation protein
K663_02940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K663_02945	COG0706	membrane insertase activity
K663_02950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K663_02955	COG0594	ribonuclease P activity
K663_02960	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K663_02975	COG1530	ribonuclease E activity
K663_02980	COG0860	N-Acetylmuramoyl-L-alanine amidase
K663_02985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K663_02990	COG1053	succinate dehydrogenase
K663_03035	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K663_03040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K663_03055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K663_03070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K663_03075	COG3920	Histidine kinase
K663_03105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K663_03110	COG2076	Multidrug Resistance protein
K663_03120	COG0488	(ABC) transporter
K663_03150	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K663_03190	COG0477	Major facilitator Superfamily
K663_03205	COG0798	PFAM Bile acid sodium symporter
K663_03265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K663_03270	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K663_03275	COG2080	2 iron, 2 sulfur cluster binding
K663_03300	COG1116	anion transmembrane transporter activity
K663_03305	COG0864	Transcriptional regulator
K663_03345	COG0457	Tetratricopeptide repeat
K663_03390	COG0183	Belongs to the thiolase family
K663_03395	COG1250	3-hydroxyacyl-CoA dehydrogenase
K663_03395	COG1024	Enoyl-CoA hydratase
K663_03420	COG1028	Short-chain dehydrogenase reductase Sdr
K663_03445	COG0277	FAD linked oxidase domain protein
K663_03495	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K663_03510	COG1737	Transcriptional regulator
K663_03520	COG3547	Transposase (IS116 IS110 IS902 family)
K663_03555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K663_03580	COG4372	Transposase
K663_03620	COG4774	siderophore transport
K663_03625	COG2819	hydrolase of the alpha beta superfamily
K663_03645	COG0582	viral genome integration into host DNA
K663_03650	COG0686	Belongs to the AlaDH PNT family
K663_03655	COG0730	response to heat
K663_03665	COG1758	RNA polymerase activity
K663_03680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K663_03715	COG0517	IMP dehydrogenase activity
K663_03715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K663_03720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K663_03750	COG1278	Cold shock
K663_03780	COG2814	Major facilitator Superfamily
K663_03790	COG0433	COG0433 Predicted ATPase
K663_03800	COG0330	HflC and HflK could
K663_03805	COG0330	HflC and HflK could
K663_03810	COG0489	protein tyrosine kinase activity
K663_03815	COG1832	CoA-binding protein
K663_03825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K663_03830	COG1028	Short-chain dehydrogenase reductase Sdr
K663_03840	COG4774	siderophore transport
K663_03850	COG3128	pkhd-type hydroxylase
K663_03885	COG0582	viral genome integration into host DNA
K663_03890	COG1595	DNA-templated transcription, initiation
K663_03905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K663_03920	COG4771	TonB-dependent receptor
K663_03940	COG3706	GGDEF domain
K663_03945	COG0583	DNA-binding transcription factor activity
K663_03950	COG2814	Major facilitator Superfamily
K663_03975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K663_03980	COG0085	RNA polymerase activity
K663_03985	COG0306	phosphate transporter
K663_03990	COG1392	Phosphate transport regulator
K663_04015	COG0137	argininosuccinate synthase activity
K663_04025	COG0745	RESPONSE REGULATOR receiver
K663_04030	COG2205	protein histidine kinase activity
K663_04035	COG0477	Major facilitator Superfamily
K663_04040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K663_04050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K663_04050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K663_04055	COG1660	Displays ATPase and GTPase activities
K663_04065	COG2205	protein histidine kinase activity
K663_04070	COG0745	RESPONSE REGULATOR receiver
K663_04075	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K663_04100	COG0330	HflC and HflK could
K663_04105	COG2301	Belongs to the HpcH HpaI aldolase family
K663_04115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K663_04125	COG0527	aspartate kinase activity
K663_04130	COG2070	2-Nitropropane dioxygenase
K663_04140	COG1733	regulation of RNA biosynthetic process
K663_04150	COG5507	3-demethylubiquinone-9 3-methyltransferase
K663_04170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K663_04190	COG0037	tRNA processing
K663_04210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K663_04210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K663_04220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K663_04225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K663_04240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K663_04250	COG0105	UTP biosynthetic process
K663_04260	COG0730	response to heat
K663_04270	COG1538	Outer membrane efflux protein
K663_04275	COG1566	PFAM secretion protein HlyD family protein
K663_04295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K663_04300	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K663_04305	COG2080	2 iron, 2 sulfur cluster binding
K663_04335	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K663_04355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K663_04375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K663_04390	COG0525	valine-tRNA ligase activity
K663_04395	COG0534	Mate efflux family protein
K663_04405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K663_04410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K663_04425	COG1160	GTP binding
K663_04440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K663_04445	COG4771	TonB-dependent receptor
K663_04465	COG1764	response to oxidative stress
K663_04470	COG0697	spore germination
K663_04485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K663_04490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K663_04495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K663_04500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K663_04505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K663_04515	COG2169	Transcriptional regulator
K663_04515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K663_04535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K663_04550	COG0101	tRNA pseudouridine synthase activity
K663_04555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K663_04560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K663_04565	COG0242	peptide deformylase activity
K663_04570	COG0745	RESPONSE REGULATOR receiver
K663_04575	COG0704	Plays a role in the regulation of phosphate uptake
K663_04580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K663_04590	COG0573	inorganic phosphate transmembrane transporter activity
K663_04615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K663_04635	COG1028	Short-chain dehydrogenase reductase Sdr
K663_04645	COG2321	neutral zinc metallopeptidase
K663_04660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K663_04670	COG2833	Protein of unknown function (DUF455)
K663_04675	COG0739	heme binding
K663_04680	COG0316	Belongs to the HesB IscA family
K663_04705	COG0456	acetyltransferase
K663_04735	COG2226	methyltransferase
K663_04745	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K663_04750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K663_04805	COG4993	Dehydrogenase
K663_04810	COG2172	sigma factor antagonist activity
K663_04840	COG1028	Short-chain dehydrogenase reductase Sdr
K663_04860	COG0673	inositol 2-dehydrogenase activity
K663_04865	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K663_04870	COG1260	myo-inositol-1-phosphate synthase
K663_04885	COG0406	alpha-ribazole phosphatase activity
K663_04900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K663_04925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K663_04940	COG4221	oxidoreductase activity
K663_04970	COG1136	(ABC) transporter
K663_04975	COG1136	(ABC) transporter
K663_04975	COG0577	efflux transmembrane transporter activity
K663_05005	COG0045	succinate-CoA ligase (ADP-forming) activity
K663_05005	COG1042	CoA-binding domain protein
K663_05005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K663_05020	COG4191	Histidine kinase
K663_05025	COG4566	intracellular signal transduction
K663_05030	COG4566	intracellular signal transduction
K663_05065	COG0517	IMP dehydrogenase activity
K663_05070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K663_05075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K663_05080	COG2249	NAD(P)H dehydrogenase (quinone) activity
K663_05085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K663_05090	COG0574	Belongs to the PEP-utilizing enzyme family
K663_05090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K663_05095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K663_05120	COG0071	Belongs to the small heat shock protein (HSP20) family
K663_05145	COG0438	transferase activity, transferring glycosyl groups
K663_05165	COG0659	secondary active sulfate transmembrane transporter activity
K663_05175	COG0745	RESPONSE REGULATOR receiver
K663_05180	COG2205	protein histidine kinase activity
K663_05185	COG1045	serine acetyltransferase
K663_05200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K663_05210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K663_05215	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K663_05235	COG0252	asparaginase activity
K663_05245	COG1329	Transcriptional regulator
K663_05250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K663_05265	COG0739	heme binding
K663_05285	COG2244	polysaccharide biosynthetic process
K663_05290	COG1213	nucleotidyl transferase
K663_05315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K663_05325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K663_05330	COG0039	L-malate dehydrogenase activity
K663_05335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K663_05345	COG0508	dehydrogenase complex catalyzes the overall conversion of
K663_05350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K663_05355	COG3706	GGDEF domain
K663_05365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K663_05370	COG1408	metallophosphoesterase
K663_05375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K663_05385	COG3153	acetyltransferase
K663_05385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K663_05390	COG0538	isocitrate dehydrogenase activity
K663_05395	COG0688	phosphatidylethanolamine metabolic process
K663_05400	COG1183	phosphatidylcholine synthase activity
K663_05410	COG0052	Belongs to the universal ribosomal protein uS2 family
K663_05415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K663_05420	COG0528	UMP kinase activity
K663_05425	COG0233	cytoplasmic translational termination
K663_05430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K663_05435	COG0575	Belongs to the CDS family
K663_05440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K663_05445	COG0750	zinc metalloprotease
K663_05460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K663_05465	COG0254	rRNA binding
K663_05470	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K663_05475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K663_05490	COG4974	Belongs to the 'phage' integrase family
K663_05495	COG0825	malonyl-CoA metabolic process
K663_05515	COG0494	nUDIX hydrolase
K663_05530	COG2311	Membrane
K663_05535	COG4106	trans-aconitate 2-methyltransferase activity
K663_05535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K663_05540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K663_05545	COG3152	Membrane
K663_05555	COG1722	exodeoxyribonuclease VII activity
K663_05560	COG0142	geranyltranstransferase activity
K663_05565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K663_05570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K663_05575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K663_05585	COG1960	acyl-CoA dehydrogenase activity
K663_05595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K663_05620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K663_05630	COG0149	triose-phosphate isomerase activity
K663_05640	COG0504	CTP synthase activity
K663_05645	COG2133	pyrroloquinoline quinone binding
K663_05650	COG0779	Required for maturation of 30S ribosomal subunits
K663_05660	COG1942	4-Oxalocrotonate Tautomerase
K663_05670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K663_05675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K663_05680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K663_05685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K663_05690	COG1185	polyribonucleotide nucleotidyltransferase activity
K663_05700	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K663_05710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K663_05715	COG0625	glutathione transferase activity
K663_05720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K663_05725	COG0459	protein refolding
K663_05730	COG3300	MHYT domain
K663_05730	COG5001	Diguanylate cyclase
K663_05745	COG0343	queuine tRNA-ribosyltransferase activity
K663_05760	COG0784	Response regulator, receiver
K663_05780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K663_05785	COG4191	Histidine kinase
K663_05790	COG2204	response regulator
K663_05795	COG2188	Transcriptional regulator
K663_05805	COG3104	oligopeptide transport
K663_05845	COG2132	Multicopper oxidase
K663_05865	COG1473	amidohydrolase
K663_05870	COG1522	sequence-specific DNA binding
K663_05880	COG0473	3-isopropylmalate dehydrogenase activity
K663_05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K663_05935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K663_05945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K663_05985	COG5487	UPF0391 membrane protein
K663_06000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K663_06010	COG0505	Belongs to the CarA family
K663_06025	COG2832	Protein of unknown function (DUF454)
K663_06030	COG2205	protein histidine kinase activity
K663_06035	COG0745	RESPONSE REGULATOR receiver
K663_06060	COG0386	Belongs to the glutathione peroxidase family
K663_06065	COG2860	membrane
K663_06070	COG0616	signal peptide processing
K663_06075	COG0588	phosphoglycerate mutase activity
K663_06085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K663_06095	COG0196	riboflavin kinase activity
K663_06100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K663_06105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K663_06115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K663_06125	COG2363	Small membrane protein
K663_06130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K663_06130	COG0475	glutathione-regulated potassium exporter activity
K663_06140	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K663_06160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K663_06170	COG0314	molybdopterin synthase activity
K663_06175	COG0583	DNA-binding transcription factor activity
K663_06180	COG0730	response to heat
K663_06185	COG1045	serine acetyltransferase
K663_06200	COG2267	carboxylic ester hydrolase activity
K663_06255	COG1595	DNA-templated transcription, initiation
K663_06260	COG3128	pkhd-type hydroxylase
K663_06275	COG0517	IMP dehydrogenase activity
K663_06290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K663_06295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K663_06300	COG1538	Outer membrane efflux protein
K663_06330	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K663_06350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K663_06355	COG1845	cytochrome c oxidase, subunit III
K663_06360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K663_06365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K663_06370	COG0477	Major facilitator Superfamily
K663_06380	COG0004	ammonium transporteR
K663_06395	COG3158	transport of potassium into the cell
K663_06400	COG2308	Evidence 4 Homologs of previously reported genes of
K663_06420	COG0492	ferredoxin-NADP+ reductase activity
K663_06435	COG0318	PFAM AMP-dependent synthetase and ligase
K663_06465	COG3409	Peptidoglycan-binding domain 1 protein
K663_06465	COG3267	Type II secretory pathway component ExeA
K663_06490	COG0367	asparagine synthase
K663_06495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K663_06535	COG2084	Dehydrogenase
K663_06540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K663_06545	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K663_06555	COG1956	GAF domain-containing protein
K663_06565	COG0564	pseudouridine synthase activity
K663_06575	COG0655	NAD(P)H dehydrogenase (quinone) activity
K663_06580	COG1741	Belongs to the pirin family
K663_06590	COG0745	RESPONSE REGULATOR receiver
K663_06605	COG1595	DNA-templated transcription, initiation
K663_06615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K663_06620	COG0717	Belongs to the dCTP deaminase family
K663_06625	COG0295	cytidine deaminase activity
K663_06635	COG5328	Belongs to the UPF0262 family
K663_06640	COG0305	Participates in initiation and elongation during chromosome replication
K663_06650	COG0175	sulfate reduction
K663_06670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K663_06670	COG1648	precorrin-2 dehydrogenase activity
K663_06675	COG1012	belongs to the aldehyde dehydrogenase family
K663_06680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K663_06720	COG1192	Involved in chromosome partitioning
K663_06735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K663_06745	COG2814	Major facilitator Superfamily
K663_06755	COG0582	viral genome integration into host DNA
K663_06760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K663_06765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K663_06785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K663_06805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K663_06810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K663_06840	COG0542	response to heat
K663_06850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K663_06855	COG0358	DNA primase activity
K663_06865	COG0505	Belongs to the CarA family
K663_06880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K663_06915	COG0148	phosphopyruvate hydratase activity
K663_06925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K663_06930	COG0508	dehydrogenase complex catalyzes the overall conversion of
K663_06930	COG0022	dehydrogenase e1 component
K663_06960	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K663_06965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K663_06980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K663_06995	COG0028	Belongs to the TPP enzyme family
K663_07000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K663_07005	COG0560	Phosphoserine phosphatase
K663_07005	COG3830	Belongs to the UPF0237 family
K663_07015	COG2989	Protein conserved in bacteria
K663_07030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K663_07040	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K663_07045	COG0154	amidase activity
K663_07050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K663_07065	COG4771	TonB-dependent receptor
K663_07085	COG0058	SHG alpha-glucan phosphorylase activity
K663_07090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K663_07095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K663_07100	COG0297	glycogen (starch) synthase activity
K663_07105	COG1523	belongs to the glycosyl hydrolase 13 family
K663_07115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K663_07120	COG1573	uracil-dna glycosylase
K663_07150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K663_07165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K663_07170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K663_07175	COG0698	ribose 5-phosphate isomerase
K663_07190	COG2945	thiolester hydrolase activity
K663_07200	COG1104	cysteine desulfurase activity
K663_07215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K663_07220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K663_07225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K663_07235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K663_07250	COG0281	malic enzyme
K663_07250	COG0280	phosphate acetyltransferase
K663_07255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K663_07270	COG0776	regulation of translation
K663_07275	COG0539	negative regulation of cytoplasmic translation
K663_07280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K663_07290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K663_07305	COG0210	DNA helicase
K663_07320	COG1959	2 iron, 2 sulfur cluster binding
K663_07330	COG0742	ribosomal rna small subunit methyltransferase
K663_07335	COG1187	pseudouridine synthase activity
K663_07360	COG0285	dihydrofolate synthase activity
K663_07365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K663_07370	COG0159	tryptophan synthase activity
K663_07375	COG0133	tryptophan synthase activity
K663_07380	COG0135	phosphoribosylanthranilate isomerase activity
K663_07405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K663_07420	COG1522	sequence-specific DNA binding
K663_07425	COG2205	protein histidine kinase activity
K663_07435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K663_07440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K663_07445	COG1116	anion transmembrane transporter activity
K663_07455	COG0840	transmembrane signaling receptor activity
K663_07470	COG2234	aminopeptidase activity
K663_07480	COG1254	Belongs to the acylphosphatase family
K663_07490	COG0288	reversible hydration of carbon dioxide
K663_07495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K663_07500	COG2867	negative regulation of translational initiation
K663_07510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K663_07510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K663_07535	COG2204	response regulator
K663_07540	COG1923	regulation of RNA biosynthetic process
K663_07545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K663_07550	COG3956	TIGRFAM MazG family protein
K663_07555	COG0477	Major facilitator Superfamily
K663_07570	COG0084	hydrolase, TatD family'
K663_07585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K663_07590	COG1686	Belongs to the peptidase S11 family
K663_07595	COG2951	lytic endotransglycosylase activity
K663_07610	COG0653	protein targeting
K663_07615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K663_07620	COG0483	inositol monophosphate 1-phosphatase activity
K663_07630	COG1074	ATP-dependent DNA helicase activity
K663_07640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K663_07645	COG3178	'Phosphotransferase
K663_07650	COG0802	atpase or kinase
K663_07655	COG2205	protein histidine kinase activity
K663_07660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K663_07665	COG1678	Uncharacterized ACR, COG1678
K663_07675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K663_07680	COG2267	carboxylic ester hydrolase activity
K663_07690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K663_07710	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K663_07715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K663_07725	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
K663_07740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K663_07745	COG0477	Major facilitator Superfamily
K663_07755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K663_07770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K663_07775	COG3800	Transcriptional regulator
K663_07775	COG1396	sequence-specific DNA binding
K663_07790	COG0166	Belongs to the GPI family
K663_07795	COG0681	Belongs to the peptidase S26 family
K663_07800	COG0571	ribonuclease III activity
K663_07805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K663_07810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K663_07810	COG1754	DNA topoisomerase type I activity
K663_07815	COG0758	DNA mediated transformation
K663_07830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K663_07835	COG0156	8-amino-7-oxononanoate synthase activity
K663_07865	COG1748	Saccharopine dehydrogenase
K663_07880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K663_07885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K663_07885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K663_07895	COG0129	dihydroxy-acid dehydratase activity
K663_07905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K663_07925	COG0741	lytic transglycosylase activity
K663_07930	COG0521	Mo-molybdopterin cofactor biosynthetic process
K663_07940	COG0587	DNA-directed DNA polymerase activity
K663_07945	COG1136	(ABC) transporter
K663_07955	COG0071	Belongs to the small heat shock protein (HSP20) family
K663_07960	COG3158	transport of potassium into the cell
K663_07970	COG3088	subunit of a heme lyase
K663_07975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K663_07980	COG1138	Cytochrome C-type biogenesis protein
K663_07985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K663_07995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K663_08000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K663_08005	COG4221	oxidoreductase activity
K663_08010	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K663_08015	COG0415	Belongs to the DNA photolyase family
K663_08020	COG1051	belongs to the nudix hydrolase family
K663_08035	COG3724	N-succinylarginine dihydrolase activity
K663_08045	COG1492	cobalamin metabolic process
K663_08055	COG0574	Belongs to the PEP-utilizing enzyme family
K663_08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K663_08060	COG0751	glycine-tRNA ligase activity
K663_08065	COG0752	glycyl-tRNA synthetase alpha subunit
K663_08080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K663_08085	COG0193	aminoacyl-tRNA hydrolase activity
K663_08090	COG0033	Phosphoglucomutase
K663_08100	COG0012	GTP binding
K663_08110	COG2030	dehydratase
K663_08120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K663_08155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K663_08160	COG1131	(ABC) transporter
K663_08165	COG0842	Transport permease protein
K663_08170	COG0842	Transport permease protein
K663_08330	COG2197	response regulator
K663_08335	COG0842	Transport permease protein
K663_08340	COG1129	ABC transporter
K663_08340	COG0842	Transport permease protein
K663_08345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K663_08360	COG1137	ATPase activity
K663_08365	COG3243	poly(R)-hydroxyalkanoic acid synthase
K663_08375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K663_08380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
K663_08400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K663_08455	COG0745	RESPONSE REGULATOR receiver
K663_08460	COG0642	Histidine kinase
K663_08505	COG2226	methyltransferase
K663_08510	COG0730	response to heat
K663_08520	COG0450	alkyl hydroperoxide reductase
K663_08525	COG3118	belongs to the thioredoxin family
K663_08530	COG0450	alkyl hydroperoxide reductase
K663_08535	COG0640	Transcriptional regulator
K663_08545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K663_08560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K663_08565	COG4988	ABC transporter
K663_08575	COG1294	oxidase, subunit
K663_08590	COG0783	Belongs to the Dps family
K663_08600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K663_08610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K663_08620	COG0659	secondary active sulfate transmembrane transporter activity
K663_08625	COG0183	Belongs to the thiolase family
K663_08635	COG2824	Alkylphosphonate utilization operon protein PhnA
K663_08640	COG3038	cytochrome b561
K663_08650	COG0640	Transcriptional regulator
K663_08670	COG0446	pyridine nucleotide-disulphide oxidoreductase
K663_08710	COG0589	response to stress
K663_08715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K663_08720	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K663_08750	COG4566	intracellular signal transduction
K663_08755	COG4191	Histidine kinase
K663_08760	COG0071	Belongs to the small heat shock protein (HSP20) family
K663_08770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K663_08780	COG3459	Glycosyltransferase 36 associated
K663_08790	COG3328	transposase activity
K663_08795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K663_08795	COG0574	Belongs to the PEP-utilizing enzyme family
K663_08955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K663_09020	COG3609	addiction module antidote protein, CC2985 family
K663_09025	COG3668	Plasmid stabilization system
K663_09085	COG1475	DNA binding
K663_09160	COG3158	transport of potassium into the cell
K663_09170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K663_09175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K663_09180	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K663_09185	COG2205	protein histidine kinase activity
K663_09195	COG3293	Transposase
K663_09270	COG1216	Glycosyl transferase, family 2
K663_09305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K663_09310	COG1546	Belongs to the CinA family
K663_09310	COG1058	Belongs to the CinA family
K663_09315	COG0024	Methionine aminopeptidase
K663_09325	COG0174	glutamine synthetase
K663_09340	COG0564	pseudouridine synthase activity
K663_09345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K663_09350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K663_09355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K663_09360	COG0740	serine-type endopeptidase activity
K663_09370	COG0544	peptidyl-prolyl cis-trans isomerase activity
K663_09390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K663_09395	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K663_09400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K663_09430	COG2815	serine threonine protein kinase
K663_09430	COG0515	serine threonine protein kinase
K663_09440	COG2826	transposase and inactivated derivatives, IS30 family
K663_09485	COG5489	Protein of unknown function (DUF736)
K663_09535	COG0739	heme binding
K663_09535	COG0741	lytic transglycosylase activity
K663_09535	COG1196	nuclear chromosome segregation
K663_09555	COG4962	Type ii secretion system protein e
K663_09570	COG3451	type IV secretory pathway VirB4
K663_09625	COG4771	TonB-dependent receptor
K663_09720	COG0583	DNA-binding transcription factor activity
K663_09725	COG0129	dihydroxy-acid dehydratase activity
K663_09740	COG0612	Peptidase, M16
K663_09745	COG0513	Belongs to the DEAD box helicase family
K663_09755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K663_09765	COG0456	acetyltransferase
K663_09770	COG4957	zinc ion binding
K663_09785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K663_09795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K663_09800	COG1253	flavin adenine dinucleotide binding
K663_09820	COG0671	phosphoesterase, PA-phosphatase related
K663_09825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K663_09830	COG1607	acyl-coa hydrolase
K663_09835	COG0508	dehydrogenase complex catalyzes the overall conversion of
K663_09845	COG0557	exoribonuclease II activity
K663_09850	COG2258	MOSC domain
K663_09860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K663_09860	COG0438	transferase activity, transferring glycosyl groups
K663_09865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K663_09875	COG1024	Enoyl-CoA hydratase
K663_09880	COG1028	Short-chain dehydrogenase reductase Sdr
K663_09885	COG0302	gtp cyclohydrolase
K663_09895	COG2814	Major facilitator Superfamily
K663_09900	COG0183	Belongs to the thiolase family
K663_09905	COG1250	3-hydroxyacyl-CoA dehydrogenase
K663_09905	COG1024	Enoyl-CoA hydratase
K663_09915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K663_09930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K663_09935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K663_09940	COG0129	dihydroxy-acid dehydratase activity
K663_09945	COG0837	glucose binding
K663_09950	COG0800	Aldolase
K663_09960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K663_09965	COG0113	porphobilinogen synthase activity
K663_09985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K663_09990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K663_10000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K663_10010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K663_10025	COG0577	efflux transmembrane transporter activity
K663_10025	COG1136	(ABC) transporter
K663_10030	COG1136	(ABC) transporter
K663_10030	COG0577	efflux transmembrane transporter activity
K663_10040	COG2200	EAL domain
K663_10045	COG0360	Binds together with S18 to 16S ribosomal RNA
K663_10050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K663_10055	COG0359	binds to the 23S rRNA
K663_10065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K663_10075	COG0194	GDP metabolic process
K663_10090	COG0114	fumarate hydratase activity
K663_10100	COG0131	Imidazoleglycerol-phosphate dehydratase
K663_10105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K663_10110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K663_10115	COG0107	imidazoleglycerol-phosphate synthase activity
K663_10120	COG0140	phosphoribosyl-ATP diphosphatase activity
K663_10130	COG0123	including yeast histone deacetylase and acetoin utilization protein
K663_10135	COG2989	Protein conserved in bacteria
K663_10160	COG0546	phosphoglycolate phosphatase activity
K663_10170	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K663_10190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K663_10220	COG2354	Protein conserved in bacteria
K663_10225	COG0534	Mate efflux family protein
K663_10235	COG0842	Transport permease protein
K663_10240	COG1131	(ABC) transporter
K663_10295	COG0617	tRNA 3'-terminal CCA addition
K663_10300	COG5001	Diguanylate cyclase
K663_10305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K663_10310	COG1877	trehalose-phosphatase activity
K663_10315	COG3387	PFAM Glycoside hydrolase 15-related
K663_10320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K663_10330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K663_10340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K663_10345	COG0047	phosphoribosylformylglycinamidine synthase activity
K663_10405	COG4964	Belongs to the GSP D family
K663_10430	COG0322	excinuclease ABC activity
K663_10435	COG1064	alcohol dehydrogenase
K663_10440	COG1064	alcohol dehydrogenase
K663_10445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K663_10450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K663_10455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K663_10460	COG0356	it plays a direct role in the translocation of protons across the membrane
K663_10485	COG2003	Belongs to the UPF0758 family
K663_10500	COG0277	FAD linked oxidase domain protein
K663_10515	COG4771	TonB-dependent receptor
K663_10530	COG1028	Short-chain dehydrogenase reductase Sdr
K663_10540	COG3335	DDE superfamily endonuclease
K663_10545	COG3273	potassium ion transport
K663_10545	COG0471	metal ion transport
K663_10575	COG3156	type II secretion system protein K
K663_10655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K663_10660	COG0134	indole-3-glycerol-phosphate synthase activity
K663_10665	COG0315	cyclic pyranopterin monophosphate synthase activity
K663_10675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K663_10680	COG2333	competence protein COMEC
K663_10680	COG0658	competence protein
K663_10685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K663_10690	COG0372	Belongs to the citrate synthase family
K663_10695	COG2205	protein histidine kinase activity
K663_10695	COG0784	Response regulator, receiver
K663_10695	COG5002	protein histidine kinase activity
K663_10725	COG0024	Methionine aminopeptidase
K663_10730	COG0489	protein tyrosine kinase activity
K663_10730	COG3206	protein involved in exopolysaccharide biosynthesis
K663_10740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K663_10750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K663_10755	COG0842	Transport permease protein
K663_10765	COG0187	DNA topoisomerase II activity
K663_10790	COG1538	Outer membrane efflux protein
K663_10810	COG0583	DNA-binding transcription factor activity
K663_10815	COG2967	ApaG domain
K663_10825	COG0473	3-isopropylmalate dehydrogenase activity
K663_10830	COG1381	Involved in DNA repair and RecF pathway recombination
K663_10840	COG2197	response regulator
K663_10855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K663_10865	COG1007	ATP synthesis coupled electron transport
K663_10880	COG0713	ATP synthesis coupled electron transport
K663_10890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K663_10895	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K663_10905	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K663_10910	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K663_10915	COG0649	NAD binding
K663_10920	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K663_10925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K663_10930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K663_10935	COG0483	inositol monophosphate 1-phosphatase activity
K663_10940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K663_10945	COG4942	peptidase
K663_10950	COG1376	ErfK ybiS ycfS ynhG family protein
K663_10955	COG0352	thiamine-phosphate diphosphorylase activity
K663_10970	COG3588	fructose-bisphosphate aldolase
K663_10975	COG0126	phosphoglycerate kinase activity
K663_10980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K663_11000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K663_11010	COG0628	permease
K663_11040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K663_11050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K663_11065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K663_11075	COG0284	orotidine-5'-phosphate decarboxylase activity
K663_11090	COG0729	surface antigen
K663_11115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K663_11130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K663_11135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K663_11140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K663_11145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K663_11160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K663_11175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K663_11200	COG0009	L-threonylcarbamoyladenylate synthase
K663_11210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K663_11215	COG0318	PFAM AMP-dependent synthetase and ligase
K663_11255	COG0670	Belongs to the BI1 family
K663_11260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K663_11265	COG2032	superoxide dismutase activity
K663_11270	COG2885	chlorophyll binding
K663_11270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K663_11355	COG4695	Portal protein
K663_11400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K663_11405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K663_11410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K663_11415	COG1028	Short-chain dehydrogenase reductase Sdr
K663_11440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K663_11470	COG1278	Cold shock
K663_11495	COG2086	electron transfer activity
K663_11500	COG0045	succinate-CoA ligase (ADP-forming) activity
K663_11515	COG1215	transferase activity, transferring glycosyl groups
K663_11675	COG0358	DNA primase activity
K663_11700	COG0592	DNA-directed DNA polymerase activity
K663_11810	COG1215	transferase activity, transferring glycosyl groups
K663_11835	COG0540	Belongs to the ATCase OTCase family
K663_11840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K663_11855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K663_11860	COG0081	regulation of translation
K663_11870	COG4651	solute:proton antiporter activity
K663_11870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K663_11875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K663_11880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K663_11890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K663_11895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K663_11920	COG1752	Esterase of the alpha-beta hydrolase superfamily
K663_11920	COG1752	Esterase of the alpha-beta hydrolase superfamily
K663_11940	COG4133	protoheme IX ABC transporter activity
K663_11945	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K663_11955	COG1605	Chorismate mutase
K663_11955	COG0287	Prephenate dehydrogenase
K663_11960	COG0142	geranyltranstransferase activity
K663_11970	COG1643	Atp-dependent helicase
K663_11985	COG0156	8-amino-7-oxononanoate synthase activity
K663_12005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K663_12010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K663_12015	COG0509	glycine decarboxylation via glycine cleavage system
K663_12020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K663_12025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K663_12035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K663_12040	COG0849	cell division
K663_12045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K663_12050	COG1181	Belongs to the D-alanine--D-alanine ligase family
K663_12055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K663_12060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K663_12065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K663_12075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K663_12080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K663_12090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K663_12105	COG0275	rRNA processing
K663_12125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K663_12140	COG0805	protein transport
K663_12145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K663_12150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K663_12155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K663_12160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K663_12175	COG0018	arginyl-trna synthetase
K663_12185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K663_12190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K663_12195	COG0328	RNA-DNA hybrid ribonuclease activity
K663_12225	COG4964	Belongs to the GSP D family
K663_12265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K663_12275	COG2204	response regulator
K663_12285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K663_12290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
K663_12295	COG0640	Transcriptional regulator
K663_12300	COG1309	transcriptional regulator
K663_12305	COG0450	alkyl hydroperoxide reductase
K663_12320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K663_12325	COG0352	thiamine-phosphate diphosphorylase activity
K663_12325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K663_12325	COG0351	phosphomethylpyrimidine kinase
K663_12330	COG3813	Protein conserved in bacteria
K663_12335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K663_12340	COG1115	amino acid carrier protein
K663_12350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K663_12355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K663_12360	COG1612	heme a metabolic process
K663_12365	COG0784	Response regulator, receiver
K663_12365	COG4191	Histidine kinase
K663_12405	COG3177	Filamentation induced by cAMP protein fic
K663_12445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K663_12465	COG0028	Belongs to the TPP enzyme family
K663_12470	COG0546	phosphoglycolate phosphatase activity
K663_12480	COG0463	Glycosyl transferase, family 2
K663_12490	COG2813	Specifically methylates the guanine in position
K663_12525	COG5489	Protein of unknown function (DUF736)
K663_12530	COG1475	DNA binding
K663_12550	COG4227	nucleotidyltransferase activity
K663_12565	COG4974	Belongs to the 'phage' integrase family
K663_12570	COG4974	Belongs to the 'phage' integrase family
K663_12575	COG4974	Belongs to the 'phage' integrase family
K663_12600	COG1476	TRANSCRIPTIONal
K663_12625	COG3916	Acyl-homoserine-lactone synthase
K663_12640	COG0302	gtp cyclohydrolase
K663_12665	COG4962	Type ii secretion system protein e
K663_12680	COG3451	type IV secretory pathway VirB4
K663_12690	COG3846	protein secretion by the type IV secretion system
K663_12695	COG3701	Conjugal transfer protein
K663_12705	COG2948	multi-organism process
K663_12730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K663_12730	COG0517	IMP dehydrogenase activity
K663_12735	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K663_12750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K663_12755	COG0438	transferase activity, transferring glycosyl groups
K663_12755	COG1216	Glycosyl transferase, family 2
K663_12780	COG2801	Transposase and inactivated derivatives
K663_12785	COG3012	SEC-C Motif Domain Protein
K663_12790	COG4372	Transposase
K663_12795	COG3436	PFAM IS66 Orf2 family protein
K663_12820	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K663_12870	COG1216	Glycosyl transferase, family 2
K663_12870	COG0438	transferase activity, transferring glycosyl groups
K663_12900	COG0438	transferase activity, transferring glycosyl groups
K663_12900	COG1216	Glycosyl transferase, family 2
K663_12945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K663_12950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K663_12975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K663_12980	COG0408	coproporphyrinogen oxidase activity
K663_12995	COG0321	lipoyl(octanoyl) transferase activity
K663_13010	COG0602	queuosine metabolic process
K663_13015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K663_13025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K663_13030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K663_13035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K663_13055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K663_13060	COG1684	flagellar biosynthetic protein fliR
K663_13065	COG1987	bacterial-type flagellum assembly
K663_13115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K663_13125	COG1677	Flagellar hook-basal body complex protein FliE
K663_13140	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
K663_13155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K663_13190	COG1815	bacterial-type flagellum-dependent cell motility
K663_13195	COG1558	bacterial-type flagellum-dependent cell motility
K663_13200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K663_13205	COG4786	Flagellar basal body rod
K663_13215	COG4786	Flagellar basal body rod
K663_13220	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K663_13225	COG1706	bacterial-type flagellum-dependent cell motility
K663_13300	COG2866	Carboxypeptidase
K663_13310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K663_13320	COG0469	pyruvate kinase activity
K663_13340	COG0393	Putative heavy-metal-binding
K663_13345	COG0217	transcriptional regulatory protein
K663_13350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K663_13360	COG1695	Transcriptional regulator
K663_13370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K663_13375	COG1420	regulation of RNA biosynthetic process
K663_13385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K663_13390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K663_13400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K663_13405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K663_13420	COG0066	3-isopropylmalate dehydratase activity
K663_13425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K663_13445	COG4166	transmembrane transport
K663_13480	COG0586	Pfam SNARE associated Golgi protein
K663_13485	COG0189	ligase activity
K663_13490	COG0792	nuclease activity
K663_13495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K663_13505	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K663_13510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K663_13525	COG0746	molybdenum cofactor guanylyltransferase activity
K663_13530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K663_13530	COG1648	precorrin-2 dehydrogenase activity
K663_13535	COG0243	molybdopterin cofactor binding
K663_13545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K663_13550	COG2223	nitrite transmembrane transporter activity
K663_13555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K663_13565	COG0488	(ABC) transporter
K663_13570	COG2814	Major facilitator Superfamily
K663_13580	COG1538	Outer membrane efflux protein
K663_13585	COG1309	transcriptional regulator
K663_13590	COG0745	RESPONSE REGULATOR receiver
K663_13600	COG1648	precorrin-2 dehydrogenase activity
K663_13600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K663_13605	COG0019	diaminopimelate decarboxylase activity
K663_13615	COG0165	Argininosuccinate lyase
K663_13620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K663_13630	COG2835	tetraacyldisaccharide 4'-kinase activity
K663_13635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K663_13640	COG3118	belongs to the thioredoxin family
K663_13660	COG0077	Prephenate dehydratase
K663_13660	COG1605	Chorismate mutase
K663_13665	COG3474	cytochrome
K663_13670	COG1253	flavin adenine dinucleotide binding
K663_13680	COG1309	transcriptional regulator
K663_13690	COG2095	MarC family integral membrane protein
K663_13700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K663_13705	COG1872	DUF167
K663_13715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K663_13720	COG0248	Ppx GppA phosphatase
K663_13725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K663_13740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K663_13745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K663_13750	COG1131	(ABC) transporter
K663_13765	COG2267	carboxylic ester hydrolase activity
K663_13775	COG0646	methionine synthase
K663_13775	COG1410	methionine synthase
K663_13810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K663_13820	COG0590	tRNA wobble adenosine to inosine editing
K663_13835	COG3279	Response regulator of the LytR AlgR family
K663_13840	COG3275	phosphorelay sensor kinase activity
K663_13845	COG1733	regulation of RNA biosynthetic process
K663_13855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K663_13860	COG0222	ribosome binding
K663_13880	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K663_13900	COG1960	acyl-CoA dehydrogenase activity
K663_13905	COG0335	large ribosomal subunit rRNA binding
K663_13910	COG0336	Belongs to the RNA methyltransferase TrmD family
K663_13920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K663_13925	COG0228	four-way junction DNA binding
K663_13930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K663_13935	COG0386	Belongs to the glutathione peroxidase family
K663_13940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K663_13945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K663_13950	COG0552	protein localization to endoplasmic reticulum
K663_13955	COG2917	probably involved in intracellular septation
K663_13980	COG0484	heat shock protein binding
K663_13985	COG3023	N-Acetylmuramoyl-L-alanine amidase
K663_13990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K663_14010	COG2198	Histidine kinase
K663_14010	COG0643	Histidine kinase
K663_14020	COG1970	mechanosensitive ion channel activity
K663_14030	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K663_14040	COG0494	nUDIX hydrolase
K663_14060	COG0243	molybdopterin cofactor binding
K663_14090	COG0537	adenosine 5'-monophosphoramidase activity
K663_14105	COG2022	thiamine diphosphate biosynthetic process
K663_14110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K663_14120	COG0439	Biotin carboxylase
K663_14145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K663_14145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K663_14150	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K663_14150	COG0662	Cupin 2, conserved barrel domain protein
K663_14160	COG0670	Belongs to the BI1 family
K663_14165	COG0215	cysteine-tRNA ligase activity
K663_14175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
K663_14190	COG5001	Diguanylate cyclase
K663_14195	COG0318	PFAM AMP-dependent synthetase and ligase
K663_14220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K663_14225	COG0484	heat shock protein binding
K663_14230	COG0443	Heat shock 70 kDa protein
K663_14250	COG1619	proteins homologs of microcin C7 resistance protein MccF
K663_14260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K663_14275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K663_14280	COG4395	Tim44
K663_14285	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K663_14295	COG0180	Tryptophanyl-tRNA synthetase
K663_14310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K663_14315	COG0268	Binds directly to 16S ribosomal RNA
K663_14320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K663_14325	COG2226	methyltransferase
K663_14330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K663_14335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K663_14340	COG0756	dUTP diphosphatase activity
K663_14345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K663_14355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K663_14360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K663_14365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K663_14380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K663_14405	COG0628	permease
K663_14420	COG0438	transferase activity, transferring glycosyl groups
K663_14425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K663_14430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K663_14460	COG0438	transferase activity, transferring glycosyl groups
K663_14470	COG0438	transferase activity, transferring glycosyl groups
K663_14475	COG0438	transferase activity, transferring glycosyl groups
K663_14490	COG1596	polysaccharide export
K663_14490	COG1596	polysaccharide export
K663_14500	COG1086	Polysaccharide biosynthesis protein
K663_14505	COG2197	response regulator
K663_14545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K663_14550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K663_14560	COG1845	cytochrome c oxidase, subunit III
K663_14570	COG3474	cytochrome
K663_14580	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K663_14630	COG0556	nucleotide-excision repair
K663_14665	COG5001	Diguanylate cyclase
K663_14665	COG3300	MHYT domain
K663_14670	COG0592	DNA-directed DNA polymerase activity
K663_14680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K663_14685	COG1285	pathogenesis
K663_14690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K663_14695	COG0406	alpha-ribazole phosphatase activity
K663_14695	COG0328	RNA-DNA hybrid ribonuclease activity
K663_14835	COG0358	DNA primase activity
K663_14845	COG0592	DNA-directed DNA polymerase activity
K663_14915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K663_14975	COG0587	DNA-directed DNA polymerase activity
K663_14980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K663_14995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K663_15015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K663_15020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K663_15025	COG0741	lytic transglycosylase activity
K663_15035	COG0793	Belongs to the peptidase S41A family
K663_15045	COG0840	transmembrane signaling receptor activity
K663_15050	COG2326	polyphosphate kinase activity
K663_15060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K663_15065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K663_15085	COG0481	GTPase activity
K663_15100	COG0563	adenylate kinase activity
K663_15105	COG0201	protein transport
K663_15110	COG0200	Binds to the 23S rRNA
K663_15115	COG1841	ribosomal large subunit assembly
K663_15120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K663_15125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K663_15130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K663_15135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K663_15140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K663_15145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K663_15150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K663_15155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K663_15160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K663_15165	COG0255	Belongs to the universal ribosomal protein uL29 family
K663_15170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K663_15175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K663_15180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K663_15185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K663_15190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K663_15195	COG0089	rRNA binding
K663_15200	COG0088	Forms part of the polypeptide exit tunnel
K663_15205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K663_15210	COG0051	transcription antitermination factor activity, RNA binding
K663_15215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K663_15220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K663_15225	COG0049	tRNA binding
K663_15230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K663_15235	COG5001	Diguanylate cyclase
K663_15235	COG3300	MHYT domain
K663_15240	COG0739	heme binding
K663_15250	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K663_15265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K663_15290	COG2824	Alkylphosphonate utilization operon protein PhnA
K663_15295	COG0659	secondary active sulfate transmembrane transporter activity
K663_15320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K663_15320	COG1017	nitric oxide dioxygenase activity
K663_15340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K663_15345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K663_15350	COG0202	RNA polymerase activity
K663_15355	COG0203	ribosomal protein L17
K663_15360	COG1505	serine-type exopeptidase activity
K663_15375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K663_15375	COG0519	Catalyzes the synthesis of GMP from XMP
K663_15385	COG1322	Protein conserved in bacteria
K663_15390	COG2119	membrane
K663_15400	COG1968	undecaprenyl-diphosphatase activity
K663_15420	COG0459	protein refolding
K663_15450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K663_15465	COG4106	trans-aconitate 2-methyltransferase activity
K663_15485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K663_15490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K663_15500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K663_15505	COG0583	DNA-binding transcription factor activity
K663_15510	COG3706	GGDEF domain
K663_15510	COG0745	RESPONSE REGULATOR receiver
K663_15520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K663_15525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K663_15530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K663_15555	COG0316	Belongs to the HesB IscA family
K663_15560	COG2151	metal-sulfur cluster biosynthetic enzyme
K663_15565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K663_15570	COG0719	Fe-S assembly protein
K663_15575	COG0396	ATPase activity
K663_15585	COG0719	Fe-S assembly protein
K663_15600	COG0167	dihydroorotate dehydrogenase activity
K663_15605	COG0405	Gamma-glutamyltransferase
K663_15635	COG1842	Phage shock protein A
K663_15640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K663_15645	COG1250	3-hydroxyacyl-CoA dehydrogenase
K663_15650	COG0824	Thioesterase
K663_15670	COG0823	Involved in the tonB-independent uptake of proteins
K663_15675	COG2885	chlorophyll binding
K663_15680	COG1846	Transcriptional regulator
K663_15690	COG0612	Peptidase, M16
K663_15700	COG0542	response to heat
K663_15705	COG4771	TonB-dependent receptor
K663_15715	COG1570	exodeoxyribonuclease VII activity
K663_15720	COG0151	Belongs to the GarS family
K663_15725	COG3743	rRNA binding
K663_15725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K663_15735	COG0483	inositol monophosphate 1-phosphatase activity
K663_15740	COG0312	modulator of DNA gyrase
K663_15750	COG1194	a g-specific adenine glycosylase
K663_15770	COG1196	nuclear chromosome segregation
K663_15775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K663_15790	COG3572	ergothioneine biosynthetic process
K663_15800	COG0632	four-way junction helicase activity
K663_15805	COG2255	four-way junction helicase activity
K663_15820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K663_15825	COG3033	Beta-eliminating lyase
K663_15840	COG2267	carboxylic ester hydrolase activity
K663_15845	COG0582	viral genome integration into host DNA
K663_15860	COG2948	multi-organism process
K663_15875	COG3846	protein secretion by the type IV secretion system
K663_15885	COG3451	type IV secretory pathway VirB4
K663_15895	COG3838	Conjugal transfer protein Trbc
K663_15900	COG4962	Type ii secretion system protein e
K663_15925	COG3012	SEC-C Motif Domain Protein
K663_15930	COG4372	Transposase
K663_15935	COG3436	PFAM IS66 Orf2 family protein
K663_15950	COG2801	Transposase and inactivated derivatives
K663_15955	COG4771	TonB-dependent receptor
K663_15960	COG1028	Short-chain dehydrogenase reductase Sdr
K663_15990	COG0179	Fumarylacetoacetate (FAA) hydrolase
K663_16000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K663_16015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K663_16020	COG1028	Short-chain dehydrogenase reductase Sdr
K663_16050	COG1028	Short-chain dehydrogenase reductase Sdr
K663_16055	COG1028	Short-chain dehydrogenase reductase Sdr
K663_16060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K663_16065	COG1960	acyl-CoA dehydrogenase activity
K663_16070	COG1250	3-hydroxyacyl-CoA dehydrogenase
K663_16070	COG1024	Enoyl-CoA hydratase
K663_16075	COG0183	Belongs to the thiolase family
K663_16085	COG0508	dehydrogenase complex catalyzes the overall conversion of
K663_16095	COG1028	Short-chain dehydrogenase reductase Sdr
K663_16115	COG3916	Acyl-homoserine-lactone synthase
K663_16145	COG4974	Belongs to the 'phage' integrase family
K663_16150	COG4974	Belongs to the 'phage' integrase family
K663_16155	COG4974	Belongs to the 'phage' integrase family
K663_16180	COG4227	nucleotidyltransferase activity
K663_16200	COG1475	DNA binding
K663_16220	COG5489	Protein of unknown function (DUF736)
K663_16235	COG0741	lytic transglycosylase activity
K663_16270	COG0326	Molecular chaperone. Has ATPase activity
K663_16275	COG0582	viral genome integration into host DNA
K663_16295	COG0583	DNA-binding transcription factor activity
K663_16315	COG4771	TonB-dependent receptor
K663_16325	COG1028	Short-chain dehydrogenase reductase Sdr
K663_16330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K663_16345	COG4771	TonB-dependent receptor
K663_16350	COG2365	Tyrosine phosphatase family
K663_16360	COG2197	response regulator
K663_16400	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
K663_16400	COG0778	Nitroreductase
K663_16415	COG0281	malic enzyme
K663_16415	COG0280	phosphate acetyltransferase
K663_16420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K663_16425	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K663_16450	COG1674	ftsk spoiiie
K663_16460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K663_16465	COG2067	long-chain fatty acid transport protein
K663_16480	COG1192	Involved in chromosome partitioning
K663_16485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K663_16495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K663_16606	COG0326	Molecular chaperone. Has ATPase activity
K663_16621	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
K663_16626	COG0784	Response regulator, receiver
K663_16626	COG4191	Histidine kinase
K663_16636	COG0753	catalase activity
K663_16651	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
K663_16716	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
K663_16721	COG4235	cytochrome complex assembly
K663_16726	COG2827	Endonuclease containing a URI domain
K663_16781	COG4191	Histidine kinase
K663_16781	COG0784	Response regulator, receiver
K663_16801	COG0583	DNA-binding transcription factor activity
K663_16811	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K663_16821	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K663_16836	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K663_16841	COG2239	Acts as a magnesium transporter
K663_16851	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K663_16856	COG1137	ATPase activity
K663_16861	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K663_16881	COG1024	Enoyl-CoA hydratase
K663_16891	COG1546	Belongs to the CinA family
K663_16891	COG1058	Belongs to the CinA family
K663_16896	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K663_16896	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K663_16906	COG1295	ribonuclease BN
K663_16916	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K663_16921	COG3047	cAMP biosynthetic process
K663_16936	COG4191	Histidine kinase
K663_16941	COG4566	intracellular signal transduction
K663_16946	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K663_16966	COG2010	Cytochrome c
K663_17011	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K663_17026	COG0644	oxidoreductase
K663_17051	COG1024	Enoyl-CoA hydratase
K663_17071	COG0667	Aldo Keto reductase
K663_17076	COG0243	molybdopterin cofactor binding
K663_17091	COG0277	FAD linked oxidase domain protein
K663_17146	COG4771	TonB-dependent receptor
K663_17151	COG1024	Enoyl-CoA hydratase
K663_17161	COG1846	Transcriptional regulator
K663_17171	COG1024	Enoyl-CoA hydratase
K663_17186	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17191	COG1902	pentaerythritol trinitrate reductase activity
K663_17201	COG1063	alcohol dehydrogenase
K663_17211	COG2146	nitrite reductase [NAD(P)H] activity
K663_17236	COG1960	acyl-CoA dehydrogenase activity
K663_17251	COG2124	cytochrome p450
K663_17256	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K663_17266	COG0183	Belongs to the thiolase family
K663_17271	COG1960	acyl-CoA dehydrogenase activity
K663_17286	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K663_17296	COG1309	transcriptional regulator
K663_17301	COG2124	cytochrome p450
K663_17306	COG4638	Rieske (2fe-2S)
K663_17326	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K663_17351	COG1024	Enoyl-CoA hydratase
K663_17406	COG4638	Rieske (2fe-2S)
K663_17411	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17431	COG0318	PFAM AMP-dependent synthetase and ligase
K663_17446	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17481	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K663_17486	COG1053	succinate dehydrogenase
K663_17501	COG1960	acyl-CoA dehydrogenase activity
K663_17506	COG1960	acyl-CoA dehydrogenase activity
K663_17511	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17526	COG1309	transcriptional regulator
K663_17536	COG0508	dehydrogenase complex catalyzes the overall conversion of
K663_17561	COG2365	Tyrosine phosphatase family
K663_17576	COG4638	Rieske (2fe-2S)
K663_17581	COG2130	NADP-dependent
K663_17621	COG0596	Alpha beta hydrolase
K663_17636	COG4638	Rieske (2fe-2S)
K663_17666	COG0300	oxidoreductase activity
K663_17671	COG4771	TonB-dependent receptor
K663_17676	COG1960	acyl-CoA dehydrogenase activity
K663_17681	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K663_17686	COG0022	dehydrogenase e1 component
K663_17696	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K663_17706	COG1053	succinate dehydrogenase
K663_17731	COG0625	glutathione transferase activity
K663_17761	COG0596	Alpha beta hydrolase
K663_17771	COG0673	inositol 2-dehydrogenase activity
K663_17781	COG4771	TonB-dependent receptor
K663_17791	COG4771	TonB-dependent receptor
K663_17801	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K663_17806	COG1228	amidohydrolase
K663_17811	COG4771	TonB-dependent receptor
K663_17816	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17851	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17861	COG0243	molybdopterin cofactor binding
K663_17866	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K663_17896	COG0243	molybdopterin cofactor binding
K663_17926	COG4638	Rieske (2fe-2S)
K663_17931	COG1053	succinate dehydrogenase
K663_17961	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17971	COG1028	Short-chain dehydrogenase reductase Sdr
K663_17986	COG2072	flavoprotein involved in K transport
K663_17991	COG4771	TonB-dependent receptor
K663_18001	COG1845	cytochrome c oxidase, subunit III
K663_18011	COG4771	TonB-dependent receptor
K663_18016	COG4638	Rieske (2fe-2S)
K663_18026	COG0446	pyridine nucleotide-disulphide oxidoreductase
K663_18026	COG1902	pentaerythritol trinitrate reductase activity
K663_18036	COG1028	Short-chain dehydrogenase reductase Sdr
K663_18056	COG2124	cytochrome p450
K663_18081	COG1028	Short-chain dehydrogenase reductase Sdr
K663_18091	COG1028	Short-chain dehydrogenase reductase Sdr
K663_18096	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K663_18101	COG0022	dehydrogenase e1 component
K663_18116	COG1028	Short-chain dehydrogenase reductase Sdr
K663_18121	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K663_18126	COG1028	Short-chain dehydrogenase reductase Sdr
K663_18146	COG4771	TonB-dependent receptor
K663_18161	COG2814	Major facilitator Superfamily
K663_18171	COG4221	oxidoreductase activity
K663_18201	COG0861	Integral membrane protein TerC family
K663_18206	COG2205	protein histidine kinase activity
K663_18206	COG5002	protein histidine kinase activity
K663_18206	COG0784	Response regulator, receiver
K663_18211	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K663_18216	COG3920	Histidine kinase
K663_18226	COG2912	Transglutaminase-like superfamily
K663_18236	COG1846	Transcriptional regulator
K663_18246	COG1218	3'(2'),5'-bisphosphate nucleotidase
K663_18256	COG0175	sulfate reduction
K663_18271	COG1024	Enoyl-CoA hydratase
K663_18286	COG0776	regulation of translation
K663_18291	COG4957	zinc ion binding
K663_18306	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K663_18311	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K663_18331	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K663_18341	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K663_18351	COG0366	Alpha amylase catalytic
K663_18356	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K663_18366	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K663_18386	COG0778	Nitroreductase
K663_18411	COG2099	Precorrin-6x reductase
K663_18426	COG2875	Belongs to the precorrin methyltransferase family
K663_18431	COG1797	cobyrinic acid a,c-diamide synthase activity
K663_18446	COG2719	SpoVR family
K663_18451	COG2718	Belongs to the UPF0229 family
K663_18456	COG2766	serine protein kinase
K663_18471	COG4964	Belongs to the GSP D family
K663_18546	COG3186	Phenylalanine-4-hydroxylase
K663_18551	COG1522	sequence-specific DNA binding
K663_18571	COG2850	peptidyl-arginine hydroxylation
K663_18596	COG0443	Heat shock 70 kDa protein
K663_18651	COG1278	Cold shock
K663_18676	COG1396	sequence-specific DNA binding
K663_18676	COG3800	Transcriptional regulator
K663_18691	COG0300	oxidoreductase activity
K663_18696	COG4774	siderophore transport
K663_18716	COG2204	response regulator
K663_18721	COG4191	Histidine kinase
K663_18726	COG1301	dicarboxylic acid transport
K663_18746	COG3022	response to hydroperoxide
K663_18766	COG0702	epimerase
K663_18791	COG0725	ABC transporter, periplasmic molybdate-binding protein
K663_18796	COG4149	molybdate abc transporter
K663_18811	COG0745	RESPONSE REGULATOR receiver
K663_18821	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K663_18826	COG1538	Outer membrane efflux protein
K663_18861	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
K663_18881	COG4181	ATPase activity
K663_18886	COG2755	lipolytic protein G-D-S-L family
K663_18891	COG1671	Belongs to the UPF0178 family
K663_18911	COG3383	formate dehydrogenase (NAD+) activity
K663_18936	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K663_18941	COG1917	Cupin 2, conserved barrel domain protein
K663_18946	COG5285	phytanoyl-CoA dioxygenase
K663_18951	COG0527	aspartate kinase activity
K663_18966	COG0668	transmembrane transport
K663_19001	COG0745	RESPONSE REGULATOR receiver
K663_19016	COG0659	secondary active sulfate transmembrane transporter activity
K663_19041	COG0730	response to heat
K663_19046	COG1271	oxidase subunit
K663_19051	COG1294	oxidase, subunit
K663_19056	COG2111	Na H antiporter
K663_19056	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K663_19061	COG1006	Multisubunit Na H antiporter MnhC subunit
K663_19066	COG0651	ATP synthesis coupled electron transport
K663_19076	COG2212	antiporter activity
K663_19086	COG0589	response to stress
K663_19091	COG0772	Belongs to the SEDS family
K663_19111	COG0589	response to stress
K663_19131	COG2365	Tyrosine phosphatase family
K663_19151	COG3335	DDE superfamily endonuclease
K663_19161	COG0667	Aldo Keto reductase
K663_19166	COG1192	Involved in chromosome partitioning
K663_19171	COG1475	DNA binding
K663_19243	COG0789	Transcriptional regulator
K663_19253	COG2226	methyltransferase
K663_19263	COG0672	)-iron permease
K663_19338	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K663_19383	COG1012	belongs to the aldehyde dehydrogenase family
K663_19393	COG2132	Multicopper oxidase
K663_19413	COG4566	intracellular signal transduction
K663_19418	COG4191	Histidine kinase
K663_19433	COG2132	Multicopper oxidase
K663_19488	COG4644	lycopene metabolic process
K663_19498	COG1252	NADH dehydrogenase
K663_19518	COG0784	Response regulator, receiver
K663_19518	COG2205	protein histidine kinase activity
K663_19533	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K663_19583	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K663_19598	COG3794	PFAM blue (type 1) copper domain protein
K663_19613	COG3022	response to hydroperoxide
K663_19618	COG4957	zinc ion binding
K663_19638	COG2850	peptidyl-arginine hydroxylation
K663_19698	COG0475	glutathione-regulated potassium exporter activity
K663_19698	COG0569	domain protein
K663_19713	COG1414	Transcriptional regulator
K663_19718	COG0183	Belongs to the thiolase family
K663_19733	COG2130	NADP-dependent
K663_19753	COG4771	TonB-dependent receptor
K663_19788	COG4771	TonB-dependent receptor
K663_19848	COG1902	pentaerythritol trinitrate reductase activity
K663_19863	COG0435	Glutathione S-transferase
K663_19873	COG0569	domain protein
K663_19873	COG0475	glutathione-regulated potassium exporter activity
K663_19893	COG0583	DNA-binding transcription factor activity
K663_19898	COG1454	alcohol dehydrogenase
K663_19913	COG0625	glutathione transferase activity
K663_19938	COG2267	carboxylic ester hydrolase activity
K663_19953	COG4771	TonB-dependent receptor
K663_19973	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_19993	COG4771	TonB-dependent receptor
K663_20003	COG0625	glutathione transferase activity
K663_20018	COG1454	alcohol dehydrogenase
K663_20088	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_20098	COG0596	Alpha beta hydrolase
K663_20123	COG0587	DNA-directed DNA polymerase activity
K663_20143	COG1024	Enoyl-CoA hydratase
K663_20148	COG1024	Enoyl-CoA hydratase
K663_20153	COG1960	acyl-CoA dehydrogenase activity
K663_20203	COG0776	regulation of translation
K663_20208	COG1196	nuclear chromosome segregation
K663_20208	COG0741	lytic transglycosylase activity
K663_20208	COG0739	heme binding
K663_20413	COG3547	Transposase (IS116 IS110 IS902 family)
K663_20418	COG4638	Rieske (2fe-2S)
K663_20438	COG1028	Short-chain dehydrogenase reductase Sdr
K663_20443	COG1028	Short-chain dehydrogenase reductase Sdr
K663_20453	COG1024	Enoyl-CoA hydratase
K663_20468	COG1024	Enoyl-CoA hydratase
K663_20478	COG1028	Short-chain dehydrogenase reductase Sdr
K663_20488	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K663_20493	COG2146	nitrite reductase [NAD(P)H] activity
K663_20528	COG0066	3-isopropylmalate dehydratase activity
K663_20533	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K663_20543	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K663_20553	COG0673	inositol 2-dehydrogenase activity
K663_20558	COG2124	cytochrome p450
K663_20593	COG4771	TonB-dependent receptor
K663_20613	COG1484	DNA-dependent DNA replication
K663_20638	COG1253	flavin adenine dinucleotide binding
K663_20683	COG1192	Involved in chromosome partitioning
K663_20758	COG3077	Addiction module antitoxin, RelB DinJ family
K663_20783	COG3328	transposase activity
K663_20788	COG4584	PFAM Integrase catalytic
K663_20793	COG1484	DNA-dependent DNA replication
K663_20823	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
K663_20863	COG4957	zinc ion binding
K663_20868	COG2003	Belongs to the UPF0758 family
K663_20883	COG2197	response regulator
K663_20888	COG4774	siderophore transport
K663_20888	COG1629	transport
K663_20928	COG3041	Addiction module toxin RelE StbE family
K663_20933	COG3077	Addiction module antitoxin, RelB DinJ family
K663_21078	COG0459	protein refolding
K663_21083	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K663_21093	COG5425	PFAM Usg family protein
K663_21103	COG0071	Belongs to the small heat shock protein (HSP20) family
K663_21108	COG0071	Belongs to the small heat shock protein (HSP20) family
K663_21273	COG4584	PFAM Integrase catalytic
K663_21278	COG1484	DNA-dependent DNA replication
K663_21283	COG2259	Doxx family
K663_21288	COG0583	DNA-binding transcription factor activity
K663_21293	COG0655	NAD(P)H dehydrogenase (quinone) activity
K663_21338	COG4584	PFAM Integrase catalytic
K663_21343	COG1484	DNA-dependent DNA replication
K663_21349	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K663_21388	COG4974	Belongs to the 'phage' integrase family
K663_21428	COG0798	PFAM Bile acid sodium symporter
K663_21448	COG1309	transcriptional regulator
K663_21453	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K663_21458	COG1131	(ABC) transporter
K663_21463	COG0842	Transport permease protein
K663_21468	COG0842	Transport permease protein
K663_21503	COG0642	Histidine kinase
K663_21508	COG0745	RESPONSE REGULATOR receiver
K663_21618	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K663_21633	COG4227	nucleotidyltransferase activity
K663_21648	COG4974	Belongs to the 'phage' integrase family
K663_21653	COG4974	Belongs to the 'phage' integrase family
K663_21658	COG4974	Belongs to the 'phage' integrase family
K663_21673	COG4227	nucleotidyltransferase activity
K663_21698	COG0420	3'-5' exonuclease activity
K663_21703	COG4717	serine-type aminopeptidase activity
K663_21733	COG1192	Involved in chromosome partitioning
K663_21778	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_21783	COG0300	oxidoreductase activity
K663_21863	COG2963	transposase activity
K663_21873	COG3436	PFAM IS66 Orf2 family protein
K663_21883	COG4372	Transposase
K663_21888	COG2433	Pfam Transposase IS66
K663_21893	COG4372	Transposase
K663_21923	COG2267	carboxylic ester hydrolase activity
K663_21958	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_21973	COG0625	glutathione transferase activity
K663_21983	COG0625	glutathione transferase activity
K663_21988	COG0625	glutathione transferase activity
K663_22013	COG0412	Dienelactone hydrolase
K663_22023	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K663_22043	COG0625	glutathione transferase activity
K663_22053	COG1309	transcriptional regulator
K663_22058	COG0625	glutathione transferase activity
K663_22068	COG2963	transposase activity
K663_22083	COG4644	lycopene metabolic process
K663_22148	COG4644	lycopene metabolic process
K663_22153	COG3547	Transposase (IS116 IS110 IS902 family)
K663_22158	COG4644	lycopene metabolic process
K663_22173	COG1053	succinate dehydrogenase
K663_22208	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K663_22223	COG0022	dehydrogenase e1 component
K663_22228	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K663_22233	COG0318	PFAM AMP-dependent synthetase and ligase
K663_22238	COG1309	transcriptional regulator
K663_22248	COG1028	Short-chain dehydrogenase reductase Sdr
K663_22263	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K663_22333	COG4227	nucleotidyltransferase activity
K663_22368	COG4644	lycopene metabolic process
K663_22408	COG1454	alcohol dehydrogenase
K663_22423	COG0625	glutathione transferase activity
K663_22433	COG4771	TonB-dependent receptor
K663_22458	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_22473	COG1192	Involved in chromosome partitioning
K663_22553	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_22598	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_22613	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K663_22623	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K663_22628	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K663_22633	COG1196	nuclear chromosome segregation
K663_22648	COG3093	addiction module antidote protein HigA
K663_22693	COG0629	single-stranded DNA binding
K663_22708	COG1192	Involved in chromosome partitioning
K663_22713	COG1475	DNA binding
K663_22743	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
K663_22748	COG2948	multi-organism process
K663_22753	COG3504	Conjugal transfer protein
K663_22758	COG3736	Type IV secretory pathway, component VirB8
K663_22778	COG3451	type IV secretory pathway VirB4
K663_22783	COG3702	type iv secretory pathway
K663_22823	COG1192	Involved in chromosome partitioning
K663_22833	COG3077	Addiction module antitoxin, RelB DinJ family
K663_22968	COG1192	Involved in chromosome partitioning
K663_22978	COG4771	TonB-dependent receptor
K663_23003	COG2267	carboxylic ester hydrolase activity