locus-tag	class	description
SHELI_v1c00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SHELI_v1c00080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SHELI_v1c00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SHELI_v1c00140	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SHELI_v1c00230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHELI_v1c00240	COG0359	binds to the 23S rRNA
SHELI_v1c00390	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SHELI_v1c00480	COG0222	ribosome binding
SHELI_v1c00580	COG0698	ribose 5-phosphate isomerase
SHELI_v1c00740	COG1739	Uncharacterized protein family UPF0029
SHELI_v1c00800	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SHELI_v1c00820	COG0492	ferredoxin-NADP+ reductase activity
SHELI_v1c00980	COG0813	purine-nucleoside phosphorylase activity
SHELI_v1c00990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SHELI_v1c01230	COG0569	domain protein
SHELI_v1c01650	COG1214	PFAM Peptidase M22, glycoprotease
SHELI_v1c01720	COG2153	protein acetylation
SHELI_v1c01870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SHELI_v1c02040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SHELI_v1c02050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SHELI_v1c02100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHELI_v1c02180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SHELI_v1c02230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SHELI_v1c02260	COG2868	ribosomal protein
SHELI_v1c02300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SHELI_v1c02360	COG0233	cytoplasmic translational termination
SHELI_v1c02420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SHELI_v1c02430	COG1187	pseudouridine synthase activity
SHELI_v1c02450	COG0217	transcriptional regulatory protein
SHELI_v1c02540	COG1077	Cell shape determining protein MreB Mrl
SHELI_v1c02590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SHELI_v1c02600	COG0776	regulation of translation
SHELI_v1c02620	COG3331	DNA recombination
SHELI_v1c02640	COG1546	Belongs to the CinA family
SHELI_v1c02640	COG1058	Belongs to the CinA family
SHELI_v1c02780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SHELI_v1c02930	COG0335	large ribosomal subunit rRNA binding
SHELI_v1c03070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHELI_v1c03290	COG0693	protein deglycase activity
SHELI_v1c03360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SHELI_v1c03520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SHELI_v1c04820	COG1131	(ABC) transporter
SHELI_v1c04830	COG1131	(ABC) transporter
SHELI_v1c04930	COG1349	DNA-binding transcription factor activity
SHELI_v1c05960	COG2255	four-way junction helicase activity
SHELI_v1c06050	COG0673	inositol 2-dehydrogenase activity
SHELI_v1c06140	COG0572	uridine kinase
SHELI_v1c06330	COG1349	DNA-binding transcription factor activity
SHELI_v1c06400	COG1185	polyribonucleotide nucleotidyltransferase activity
SHELI_v1c06400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SHELI_v1c06400	COG0539	negative regulation of cytoplasmic translation
SHELI_v1c06680	COG1381	Involved in DNA repair and RecF pathway recombination
SHELI_v1c06990	COG0736	holo-[acyl-carrier-protein] synthase activity
SHELI_v1c07050	COG0564	pseudouridine synthase activity
SHELI_v1c07200	COG2001	Belongs to the MraZ family
SHELI_v1c07220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SHELI_v1c07330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SHELI_v1c07380	COG1098	S1 RNA binding domain
SHELI_v1c07440	COG0719	Fe-S assembly protein
SHELI_v1c07830	COG0742	ribosomal rna small subunit methyltransferase
SHELI_v1c08120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHELI_v1c08120	COG0072	phenylalanine-tRNA ligase activity
SHELI_v1c08160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHELI_v1c08290	COG1882	Formate acetyltransferase
SHELI_v1c08320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SHELI_v1c08510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SHELI_v1c08520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SHELI_v1c08570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SHELI_v1c08580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SHELI_v1c08590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SHELI_v1c08620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SHELI_v1c08690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SHELI_v1c08720	COG0089	rRNA binding
SHELI_v1c08740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SHELI_v1c08750	COG0051	transcription antitermination factor activity, RNA binding
SHELI_v1c08860	COG1119	ATPase activity
SHELI_v1c09480	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SHELI_v1c09560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHELI_v1c09600	COG1869	D-ribose catabolic process
SHELI_v1c11060	COG0254	rRNA binding
SHELI_v1c11200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SHELI_v1c11240	COG1475	DNA binding
SHELI_v1c11250	COG1192	Involved in chromosome partitioning
SHELI_v1c11320	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SHELI_v1c11350	COG0193	aminoacyl-tRNA hydrolase activity
SHELI_v1c11360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SHELI_v1c11410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SHELI_v1c11440	COG1077	Cell shape determining protein MreB Mrl
SHELI_v1c11580	COG0594	ribonuclease P activity