locus-tag class description CSC52_0001 ENOG41067FT ParB-like nuclease domain CSC52_0002 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CSC52_0004 ENOG4105DUU IucA IucC family protein CSC52_0005 ENOG4105DBM Siderophore biosynthesis protein CSC52_0006 ENOG4105C6X Major Facilitator CSC52_0007 ENOG4105DJU Siderophore biosynthesis protein CSC52_0008 ENOG4105CIF Ornithine Cyclodeaminase CSC52_0010 ENOG4108MES Periplasmic binding protein CSC52_0011 ENOG4105DQ5 transport system permease protein CSC52_0012 ENOG4108IHU transport system permease protein CSC52_0017 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSC52_0018 ENOG4107Y9U Membrane CSC52_0019 ENOG4105CCI Myosin-Cross-Reactive Antigen CSC52_0022 ENOG4105C57 major facilitator superfamily CSC52_0030 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CSC52_0036 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CSC52_0038 ENOG4105C5X domain protein CSC52_0039 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CSC52_0040 ENOG4105XTG Pfam:DUF156 CSC52_0041 ENOG41087NI Sulfite exporter TauE/SafE CSC52_0049 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CSC52_0050 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CSC52_0051 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CSC52_0052 ENOG4105C08 Histidine kinase CSC52_0053 ENOG4105EEX Two component transcriptional regulator (Winged helix family CSC52_0055 ENOG4105CSX c4-dicarboxylate anaerobic carrier CSC52_0059 ENOG4105DQ6 Transposase CSC52_0068 ENOG410826E Dna repair protein radc CSC52_0069 ENOG4108FPN Integrase CSC52_0070 ENOG4108KU9 integrase family CSC52_0071 ENOG4108KU9 integrase family CSC52_0072 ENOG4105ZX1 Transposase C CSC52_0073 ENOG4106JUT Streptomycin 3''-adenylyltransferase CSC52_0074 ENOG41071EZ rRNA adenine N-6-methyltransferase CSC52_0076 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CSC52_0077 ENOG41087NI Sulfite exporter TauE/SafE CSC52_0078 ENOG4105XTG Pfam:DUF156 CSC52_0079 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CSC52_0080 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CSC52_0084 ENOG4105CCN Peptidase M56 CSC52_0085 ENOG4107RVG penicillin-binding protein CSC52_0086 ENOG4108ZMQ domain protein CSC52_0087 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CSC52_0089 ENOG4108S3A nucleotidyltransferase CSC52_0091 ENOG4106PHI plasmid recombination enzyme CSC52_0099 ENOG4105CGH 5'-nucleotidase CSC52_0100 ENOG4105Q2H domain protein CSC52_0107 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CSC52_0108 ENOG4105CDU Replicative dna helicase CSC52_0110 ENOG4105BZR domain protein CSC52_0112 ENOG4105DWV Homoserine O-trans-acetylase CSC52_0117 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CSC52_0118 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC52_0119 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC52_0121 ENOG410848D S4 domain protein YaaA CSC52_0122 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CSC52_0129 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CSC52_0136 ENOG4105C19 ABC transporter CSC52_0139 ENOG4105D9G High-affinity CSC52_0141 ENOG4105FR1 rard protein CSC52_0142 ENOG4107QPK )-transporter CSC52_0158 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CSC52_0159 ENOG4105CIH Imidazole acetol-phosphate transaminase CSC52_0161 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CSC52_0164 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CSC52_0166 ENOG4105J1V Triacylglycerol lipase CSC52_0168 ENOG4107UVV polysaccharide deacetylase CSC52_0170 ENOG4107QJZ Glycosyl transferase, family 2 CSC52_0171 ENOG4108IG5 Transcriptional regulator CSC52_0172 ENOG4105HTX biosynthesis protein CSC52_0176 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CSC52_0177 ENOG4107XC4 flavin reductase domain protein, FMN-binding CSC52_0181 ENOG4105EW6 flavin reductase domain protein, FMN-binding CSC52_0185 ENOG4108XJK accessory Sec system protein Asp1 CSC52_0186 ENOG41089G2 accessory Sec system protein Asp2 CSC52_0187 ENOG4106E62 Accessory Sec system protein Asp3 CSC52_0192 ENOG4105WQI isochorismatase CSC52_0193 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase CSC52_0195 ENOG4105DG6 mannose-6-phosphate isomerase CSC52_0196 ENOG4105DM4 PTS System CSC52_0203 ENOG4105DBV ornithine carbamoyltransferase CSC52_0204 ENOG4105D5Q Arginine ornithine antiporter CSC52_0206 ENOG4105C5B carbamate kinase CSC52_0208 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps CSC52_0210 ENOG4108U05 Transcriptional regulator CSC52_0211 ENOG4105G6Z alkaline phosphatase CSC52_0219 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CSC52_0220 ENOG4108Z73 Siroheme synthase CSC52_0221 ENOG4105D4T Citrate transporter CSC52_0222 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CSC52_0223 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CSC52_0224 ENOG4105C94 Transporter CSC52_0225 ENOG4105TRT Transcriptional regulator CSC52_0226 ENOG4105C26 Dehydrogenase CSC52_0230 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CSC52_0232 ENOG4105DWT malate dehydrogenase (quinone) CSC52_0235 ENOG4108JPW Aminotransferase CSC52_0236 ENOG4105CUB amino acid CSC52_0238 ENOG4107FQX Alpha-acetolactate decarboxylase CSC52_0239 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CSC52_0250 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CSC52_0251 ENOG4105FGM Fructosamine kinase CSC52_0255 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase CSC52_0260 ENOG4105CHR reductase CSC52_0272 ENOG4105EXC Acyl-transferase CSC52_0273 ENOG41068JE domain protein CSC52_0275 ENOG4105EWK phytoene CSC52_0276 ENOG41076QQ Glycosyl transferase, family 2 CSC52_0277 ENOG4105FE1 phytoene synthase CSC52_0288 ENOG4105EYF MMPL domain protein CSC52_0290 ENOG4105CE1 Ferrous iron transport protein b CSC52_0292 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSC52_0293 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSC52_0294 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CSC52_0296 ENOG41068JE domain protein CSC52_0298 ENOG4105CMU LysR family (Transcriptional regulator CSC52_0300 ENOG41067MG lrgb family CSC52_0306 ENOG4108UZ3 Transporter CSC52_0309 ENOG4105EJQ L-serine dehydratase CSC52_0310 ENOG4108Z7F N-acetyltransferase CSC52_0311 ENOG4108Z6X (sortase) family CSC52_0312 ENOG4106KKU CSC52_0313 ENOG4108Z15 abc transporter atp-binding protein CSC52_0314 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CSC52_0315 ENOG4105C5I Dehydrogenase CSC52_0317 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CSC52_0319 ENOG41090MY MarR family Transcriptional regulator CSC52_0321 ENOG4105FBA Phospholipase Carboxylesterase CSC52_0322 ENOG4108K88 Membrane CSC52_0325 ENOG4105CJ1 ABC, transporter CSC52_0326 ENOG4107T5V SNARE associated Golgi CSC52_0327 ENOG4105DJB Major Facilitator Superfamily CSC52_0329 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CSC52_0332 ENOG4105G3Z GntR family transcriptional regulator CSC52_0333 ENOG4105CMG Carbohydrate kinase CSC52_0344 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CSC52_0346 ENOG4105M6F mutator MutT protein CSC52_0362 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CSC52_0363 ENOG4105CFC Transporter CSC52_0364 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CSC52_0365 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein CSC52_0377 ENOG4105CBC glutamate synthase CSC52_0378 ENOG4105PQ4 (LipO)protein CSC52_0381 ENOG4105CN9 Peptidase m42 family protein CSC52_0382 ENOG41083J0 (ABC) transporter CSC52_0383 ENOG4105C4B ABC transporter, permease CSC52_0384 ENOG4105F27 Major Facilitator CSC52_0385 ENOG4105EBR Carboxylesterase CSC52_0387 ENOG4107QTZ amino acid CSC52_0388 ENOG4105CZ9 Domain of unknown function (DU1801) CSC52_0390 ENOG4105E90 ABC transporter CSC52_0392 ENOG4105R40 Glycine betaine carnitine choline CSC52_0393 ENOG4105C57 major facilitator superfamily CSC52_0394 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CSC52_0396 ENOG4105ED2 Beta-lactamase CSC52_0397 ENOG4105C0X amino acid CSC52_0398 ENOG4105EEQ Na H antiporter CSC52_0399 ENOG4105C85 amino acid CSC52_0403 ENOG4105C2C drug resistance transporter, Bcr CflA CSC52_0405 ENOG4105BZW Glycerate kinase CSC52_0408 ENOG4105BZ1 (ABC) transporter CSC52_0409 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CSC52_0410 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSC52_0412 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CSC52_0415 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CSC52_0422 ENOG4105EAB amino acid AbC transporter CSC52_0423 ENOG4105DRP amino acid AbC transporter CSC52_0424 ENOG4105CDA abc transporter atp-binding protein CSC52_0430 ENOG4105DSE periplasmic solute binding protein CSC52_0433 ENOG4105TMB Formate nitrite transporter CSC52_0434 ENOG4108XSB acetyltransferase, (GNAT) family CSC52_0436 ENOG4108IFG nitrite reductase, (NAD(P)H) CSC52_0437 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CSC52_0438 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CSC52_0440 ENOG4108IUE nitrate reductase beta subunit CSC52_0446 ENOG4107TXC Transcriptional regulator CSC52_0454 ENOG410606W general stress protein CSC52_0460 ENOG4105ECB domain protein CSC52_0471 ENOG4105DWT malate dehydrogenase (quinone) CSC52_0477 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CSC52_0479 ENOG41062A4 Transcriptional regulator CSC52_0483 ENOG4105CW7 secretion protein, HlyD family CSC52_0484 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSC52_0489 ENOG4105D7N magnesium and cobalt transport protein CorA CSC52_0491 ENOG4105D6U Sodium Glutamate Symporter CSC52_0493 ENOG4105KAF membrAne CSC52_0494 ENOG4108IUX (ABC) transporter CSC52_0495 ENOG4105RHA ABC transporter, permease CSC52_0499 ENOG4108RPX mosc domain containing protein CSC52_0500 ENOG4105E66 phosphoriboisomerase A CSC52_0505 ENOG4105C5Q Transcriptional regulator CSC52_0506 ENOG4105CGP Urocanate hydratase CSC52_0508 ENOG4105CH2 amidohydrolase CSC52_0509 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CSC52_0514 ENOG4108Q3X Transcriptional regulator CSC52_0515 ENOG4105CI1 PTS System CSC52_0516 ENOG4105CI1 PTS System CSC52_0518 ENOG4105C09 Bile acid CSC52_0519 ENOG4107YBY Hydrolase CSC52_0533 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CSC52_0539 ENOG4105DFD Na H antiporter CSC52_0540 ENOG41068JE domain protein CSC52_0553 ENOG4105FDT acyl-CoA dehydrogenase CSC52_0556 ENOG4107ZYJ bioY protein CSC52_0559 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CSC52_0560 ENOG4105E0C molybdate abc transporter CSC52_0561 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CSC52_0562 ENOG4105D06 uba thif-type nad fad binding protein CSC52_0563 ENOG4105EPU Molybdenum cofactor synthesis domain protein CSC52_0565 ENOG4105CVM Molybdenum cofactor synthesis domain protein CSC52_0566 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CSC52_0567 ENOG4108ZAF Molybdopterin CSC52_0575 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) CSC52_0581 ENOG4105CSC Glucose uptake protein CSC52_0584 ENOG4105C7N Xanthine uracil vitamin C permease CSC52_0607 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CSC52_0608 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CSC52_0615 ENOG4108JJB ABC transporter CSC52_0627 ENOG4107RRE RNA-directed DNA polymerase CSC52_0629 ENOG4107FQX Alpha-acetolactate decarboxylase CSC52_0633 ENOG4106AM8 polysaccharide lyase family 8 CSC52_0635 ENOG4105VUF Transcriptional regulator CSC52_0638 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CSC52_0639 ENOG4105E98 transcriptional regulator DeoR family CSC52_0644 ENOG4105VCP PTS System CSC52_0645 ENOG4105CK1 PTS System CSC52_0654 ENOG41067QW Transcriptional regulator CSC52_0708 ENOG4108FKH Transglycosylase SLT domain CSC52_0721 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CSC52_0724 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CSC52_0725 ENOG4105CIS alcohol dehydrogenase CSC52_0726 ENOG4105C94 Transporter CSC52_0731 ENOG4107SFI Major Facilitator superfamily CSC52_0733 ENOG4106M28 alanine racemase domain protein CSC52_0734 ENOG4108HUF Transporter CSC52_0735 ENOG4105DQ5 transport system permease protein CSC52_0736 ENOG4108U1V ABC transporter, permease CSC52_0737 ENOG4105DWD nucleoside recognition domain protein CSC52_0739 ENOG4107K5X Membrane-bound metal-dependent hydrolase CSC52_0740 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase CSC52_0741 ENOG4108UT2 hemolysin iii CSC52_0745 ENOG4105D1F ATP-binding protein CSC52_0755 ENOG4105CYW agmatinase CSC52_0756 ENOG4105C8B TIGR00159 family CSC52_0761 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CSC52_0762 ENOG4105ETD TRANSCRIPTIONal CSC52_0763 ENOG4105CTS PTS system mannitol-specific CSC52_0764 ENOG4105CTS PTS system mannitol-specific CSC52_0765 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CSC52_0766 ENOG4105DKW ABC transporter CSC52_0771 ENOG4105PGM cation diffusion facilitator family transporter CSC52_0774 ENOG4105DG6 mannose-6-phosphate isomerase CSC52_0778 ENOG4108RMU ferritin dps family protein CSC52_0779 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CSC52_0780 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CSC52_0781 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CSC52_0787 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CSC52_0792 ENOG4105D2N Aldolase CSC52_0796 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CSC52_0798 ENOG4107104 thymidine kinase CSC52_0800 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CSC52_0801 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSC52_0806 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CSC52_0817 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CSC52_0824 ENOG4105DWF phosphomethylpyrimidine kinase CSC52_0829 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSC52_0830 ENOG4105VPX protein, conserved in bacteria CSC52_0833 ENOG4105CNI cell division protein FtsW CSC52_0836 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CSC52_0840 ENOG4105EEX Two component transcriptional regulator (Winged helix family CSC52_0841 ENOG4105C08 Histidine kinase CSC52_0842 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CSC52_0843 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CSC52_0844 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CSC52_0846 ENOG4105CKV Membrane CSC52_0849 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSC52_0852 ENOG4107SGM protein serine threonine phosphatase CSC52_0853 ENOG4105WN5 stage II sporulation protein CSC52_0866 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CSC52_0870 ENOG4105C7K acetolactate synthase CSC52_0872 ENOG4105K8N protein family UPF0079, ATPase CSC52_0873 ENOG41072GX Peptidase M22 Glycoprotease CSC52_0874 ENOG410801F ribosomal-protein-alanine acetyltransferase CSC52_0876 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CSC52_0878 ENOG4105C5H ABC transporter CSC52_0880 ENOG4105CUC YeeE YedE family protein CSC52_0882 ENOG4105BZU Histidine kinase CSC52_0886 ENOG4108WCX response regulator CSC52_0897 ENOG4105CZN Potassium uptake protein CSC52_0901 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CSC52_0941 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CSC52_0952 ENOG4105DR5 peptidase CSC52_0960 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CSC52_0962 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CSC52_0966 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CSC52_0971 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CSC52_0974 ENOG4105CJ1 ABC, transporter CSC52_0984 ENOG4105C26 Dehydrogenase CSC52_0989 ENOG4105C8P )-transporter CSC52_0990 ENOG4105CQC Prephenate dehydratase CSC52_0991 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) CSC52_0992 ENOG4105DAP Nicotinate phosphoribosyltransferase CSC52_0997 ENOG4107DDB Cysteine protease able to CSC52_0999 ENOG4105KGF protein, YerC YecD CSC52_1001 ENOG4105C4R Atp-dependent dna helicase CSC52_1023 ENOG4105ENE Histidine kinase CSC52_1025 ENOG4107U9T Pfam:Ribonuclease_BN CSC52_1030 ENOG4108S4H thioesterase Superfamily protein CSC52_1037 ENOG4105EY8 ABC transporter CSC52_1039 ENOG41067AE Membrane-bound metal-dependent hydrolase CSC52_1043 ENOG4107NBY Membrane CSC52_1045 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSC52_1046 ENOG4108M3J Dehydrogenase CSC52_1047 ENOG4105G5W regulator Fur family CSC52_1083 ENOG4105E5Q amino acid AbC transporter CSC52_1084 ENOG4105CDA abc transporter atp-binding protein CSC52_1085 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CSC52_1090 ENOG4105C9Q fumarate hydratase class II CSC52_1091 ENOG4108YBP pseudouridine synthase CSC52_1092 ENOG4105BZU Histidine kinase CSC52_1093 ENOG4105WH1 Two component transcriptional regulator luxr family CSC52_1097 ENOG4107VRP DNA repair exonuclease CSC52_1103 ENOG4105K59 histidine triad (HIT) protein CSC52_1109 ENOG4105C1Q protoporphyrinogen oxidase CSC52_1158 ENOG4105E09 nadh pyrophosphatase CSC52_1164 ENOG4105CV8 reductase CSC52_1167 ENOG4105WMR Protein CrcB homolog CSC52_1168 ENOG4106A8V Protein CrcB homolog CSC52_1170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CSC52_1176 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CSC52_1177 ENOG4107R3E Citrate transporter CSC52_1179 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CSC52_1180 ENOG4108R6K riboflavin synthase, subunit alpha CSC52_1181 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CSC52_1184 ENOG4105E8V Alpha Beta Hydrolase Fold protein CSC52_1190 ENOG4105N5T Radical SAM Protein CSC52_1191 ENOG410605W Major Facilitator CSC52_1195 ENOG4105CBX hi0933 family CSC52_1200 ENOG4105F0I Aminotransferase CSC52_1201 ENOG4108V15 phosphotransferase enzyme family CSC52_1203 ENOG4105C8F Beta-lactamase domain protein CSC52_1208 ENOG4108VDD TRNA binding domain protein CSC52_1213 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CSC52_1214 ENOG4105ETE Transcriptional regulator (LacI family CSC52_1215 ENOG4105DGU Histone deacetylase CSC52_1222 ENOG4105C0H protease CSC52_1223 ENOG4105F6E Acyl-transferase CSC52_1226 ENOG4108JQ1 Dehydrogenase CSC52_1227 ENOG4105C5R Aminotransferase CSC52_1228 ENOG4108X3M OsmC Ohr family protein CSC52_1229 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CSC52_1237 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CSC52_1246 ENOG4105SFS phosphoesterase RecJ domain protein CSC52_1247 ENOG4105C0B DNA polymerase III (alpha subunit) CSC52_1248 ENOG4105C6K Malic enzyme CSC52_1253 ENOG4105C85 amino acid CSC52_1254 ENOG4105BZN citrate synthase CSC52_1255 ENOG4108HMX isocitrate dehydrogenase (NADP) CSC52_1256 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSC52_1257 ENOG4105BZU Histidine kinase CSC52_1260 ENOG4105C2M dna polymerase I CSC52_1261 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CSC52_1263 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSC52_1268 ENOG4108IQI permease CSC52_1272 ENOG4105U6W MutT NUDIX family protein CSC52_1281 ENOG4105D52 delta-aminolevulinic acid dehydratase CSC52_1285 ENOG4108R3E Dna-3-methyladenine glycosylase i CSC52_1287 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CSC52_1288 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) CSC52_1290 ENOG4108FPN Integrase CSC52_1291 ENOG4108FPN Integrase CSC52_1292 ENOG4108KU9 integrase family CSC52_1293 ENOG4108KU9 integrase family CSC52_1295 ENOG4106JUT Streptomycin 3''-adenylyltransferase CSC52_1296 ENOG4106JUT Streptomycin 3''-adenylyltransferase CSC52_1297 ENOG41071EZ rRNA adenine N-6-methyltransferase CSC52_1298 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CSC52_1305 ENOG4105X36 (ribosomal) protein CSC52_1313 ENOG4105VIE preprotein translocase, subunit YajC CSC52_1314 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CSC52_1315 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CSC52_1322 ENOG4105CUZ uba thif-type nad fad binding protein CSC52_1323 ENOG4105D1H recombination factor protein RarA CSC52_1326 ENOG4105DEN Luciferase family CSC52_1327 ENOG4105C3J Cysteine desulfurase CSC52_1330 ENOG4105C7H Helicase, RecD TraA family CSC52_1336 ENOG4105XYU peptidase (U32 family) CSC52_1337 ENOG4105CFP Peptidase U32 CSC52_1340 ENOG4105P4J Allophanate hydrolase, subunit 1 CSC52_1342 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CSC52_1343 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSC52_1345 ENOG4105C5A transporter CSC52_1354 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CSC52_1355 ENOG4105CQW ribosome biogenesis GTPase YqeH CSC52_1357 ENOG410812S Rna-binding protein CSC52_1359 ENOG4108WF2 Metal Dependent Phosphohydrolase CSC52_1360 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CSC52_1361 ENOG4105DXX methyltransferase CSC52_1362 ENOG4105BZM domain protein CSC52_1363 ENOG4108UK2 deaminase CSC52_1364 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CSC52_1365 ENOG4105TQK DNA polymerase iii, delta' subunit CSC52_1368 ENOG4105CSA Coproporphyrinogen iii oxidase CSC52_1374 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CSC52_1375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CSC52_1377 ENOG4105F7J membrane-bound serine protease CSC52_1380 ENOG4105C9A Phoh family CSC52_1383 ENOG4105KG3 cytidine deaminase CSC52_1389 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CSC52_1390 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSC52_1392 ENOG4105EGD dinuclear metal center protein, YbgI family CSC52_1393 ENOG4105C1J atp-dependent rna helicase CSC52_1395 ENOG4105FDK ABC transporter CSC52_1396 ENOG4105FAV ABC, transporter CSC52_1397 ENOG4105N80 Ferric uptake regulator, Fur family CSC52_1399 ENOG4107RF6 penicillin-binding protein CSC52_1401 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CSC52_1406 ENOG4105C5X domain protein CSC52_1408 ENOG4105D7Q type ii secretion system CSC52_1409 ENOG4106855 Competence protein CSC52_1417 ENOG4105WZW rhodanese family CSC52_1418 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CSC52_1421 ENOG4105DC7 peptidase M24 CSC52_1424 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSC52_1425 ENOG4108ZSR alkaline shock protein CSC52_1431 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CSC52_1434 ENOG4105CPP Dehydrogenase, E1 component CSC52_1435 ENOG4105C7S Dehydrogenase CSC52_1437 ENOG4108QEG Membrane CSC52_1439 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CSC52_1440 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CSC52_1446 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CSC52_1449 ENOG4105II7 pyrroline-5-carboxylate reductase CSC52_1450 ENOG4105PDP Short chain dehydrogenase CSC52_1452 ENOG4105CPC Aldo Keto reductase CSC52_1453 ENOG4108YZ4 nudix hydrolase CSC52_1454 ENOG4105I3K Ferric uptake regulator, Fur family CSC52_1455 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSC52_1459 ENOG4105FE9 pseudouridine synthase CSC52_1460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSC52_1461 ENOG4105BZU Histidine kinase CSC52_1470 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CSC52_1471 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CSC52_1513 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CSC52_1527 ENOG4108FKH Transglycosylase SLT domain CSC52_1542 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CSC52_1543 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CSC52_1553 ENOG4105C9U ATP-dependent DNA helicase RecQ CSC52_1554 ENOG4106BU8 elastin-binding protein ebpS CSC52_1555 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CSC52_1556 ENOG4105HDK L-asparaginase CSC52_1558 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CSC52_1561 ENOG4105K70 DNA-binding protein CSC52_1564 ENOG4105EAH synthase CSC52_1574 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CSC52_1575 ENOG4105CPK Glycosyl transferase (Group 1 CSC52_1581 ENOG4105CSM endonuclease III CSC52_1583 ENOG4105BZ4 penicillin-binding protein CSC52_1589 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CSC52_1592 ENOG410890F Dynamin family CSC52_1595 ENOG4105C7B Threonine dehydratase CSC52_1596 ENOG4107R7I amino acid CSC52_1605 ENOG4106QQ5 PBS lyase HEAT domain protein repeat-containing protein CSC52_1609 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CSC52_1611 ENOG4108FKN Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CSC52_1613 ENOG4105C5Y PTS System CSC52_1615 ENOG4105CN1 protease CSC52_1618 ENOG410841Q phosphoesterase PA-phosphatase related protein CSC52_1622 ENOG4105C7S Dehydrogenase CSC52_1626 ENOG4107T89 von Willebrand factor, type A CSC52_1634 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CSC52_1635 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSC52_1640 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSC52_1641 ENOG4105CFH Aspartokinase CSC52_1642 ENOG4105C5H ABC transporter CSC52_1646 ENOG4105C8U phosphate abc transporter CSC52_1647 ENOG4105E2Z phosphate ABC transporter (Permease CSC52_1649 ENOG4108UTW Plays a role in the regulation of phosphate uptake CSC52_1650 ENOG4105DPN Oligoendopeptidase f CSC52_1652 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC52_1653 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC52_1655 ENOG4108JMM (ABC) transporter CSC52_1657 ENOG4108KP7 hydrolase CSC52_1659 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) CSC52_1660 ENOG4108RMH femAB family CSC52_1666 ENOG4105DDQ anthranilate synthase CSC52_1667 ENOG4105CRQ synthase (Component I) CSC52_1668 ENOG4105DER m42 family CSC52_1669 ENOG4105EVN Prephenate dehydrogenase CSC52_1670 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSC52_1672 ENOG4108RCF TRANSCRIPTIONal CSC52_1673 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CSC52_1674 ENOG4105FF5 Membrane CSC52_1678 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC52_1679 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSC52_1683 ENOG4108I0Z Aconitate hydratase CSC52_1685 ENOG4105C94 Transporter CSC52_1691 ENOG4105CV1 Transketolase (EC 2.2.1.1) CSC52_1695 ENOG4105K4I Scp-like extracellular CSC52_1701 ENOG4108IQI permease CSC52_1705 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CSC52_1706 ENOG4105D6E homoserine dehydrogenase CSC52_1707 ENOG4105CFH Aspartokinase CSC52_1712 ENOG4108S01 response regulator CSC52_1715 ENOG4108M15 ABC transporter CSC52_1716 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSC52_1726 ENOG4105C5F glutamine synthetase CSC52_1727 ENOG4105KV4 Transcriptional regulator CSC52_1728 ENOG4105CXI aluminum resistance protein CSC52_1729 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CSC52_1730 ENOG4108V06 Glutathione peroxidase CSC52_1731 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CSC52_1736 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSC52_1738 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CSC52_1745 ENOG4105DQU oxidoreductase, subunit beta CSC52_1746 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CSC52_1747 ENOG4105D48 metallophosphoesterase CSC52_1751 ENOG4105CEV competence damage-inducible protein CSC52_1752 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CSC52_1755 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CSC52_1758 ENOG4105FDP GntR family transcriptional regulator CSC52_1759 ENOG4105CNU cell division protein FtsK CSC52_1763 ENOG4105DTN riboflavin biosynthesis protein ribF CSC52_1768 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CSC52_1769 ENOG4105CHV Transcription elongation factor NusA CSC52_1774 ENOG4105KNE Phosphatidate cytidylyltransferase CSC52_1775 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CSC52_1786 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CSC52_1787 ENOG4105C79 DNA protecting protein DprA CSC52_1788 ENOG4105C79 DNA protecting protein DprA CSC52_1789 ENOG4108RMH femAB family CSC52_1791 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CSC52_1794 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CSC52_1802 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CSC52_1803 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CSC52_1806 ENOG4105CHR reductase CSC52_1807 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CSC52_1810 ENOG4105CB5 ATP-dependent DNA helicase recG CSC52_1812 ENOG4108ZAA Alkaline-shock protein CSC52_1815 ENOG4105DJV ribulose-phosphate 3-epimerase CSC52_1816 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CSC52_1818 ENOG4108ZF3 Phosphatase CSC52_1820 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CSC52_1822 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CSC52_1823 ENOG4105YB8 TM2 domain containing protein CSC52_1825 ENOG4105C25 Primosomal protein n' CSC52_1826 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CSC52_1828 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CSC52_1829 ENOG4105F23 Fibronectin-binding protein CSC52_1832 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CSC52_1835 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CSC52_1836 ENOG4105CD3 dihydroorotase CSC52_1840 ENOG4105C34 Pseudouridine synthase CSC52_1842 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CSC52_1846 ENOG4105DBK s4 domain protein CSC52_1847 ENOG41067XK integral membrane protein CSC52_1849 ENOG4105DFA alanine racemase domain protein CSC52_1850 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CSC52_1851 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CSC52_1852 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CSC52_1853 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CSC52_1856 ENOG4105CJN penicillin-binding protein CSC52_1857 ENOG41068DC Essential cell division protein (By similarity) CSC52_1868 ENOG4105CSX c4-dicarboxylate anaerobic carrier CSC52_1870 ENOG4105DBV ornithine carbamoyltransferase CSC52_1877 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity CSC52_1892 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CSC52_1894 ENOG4105E33 succinate dehydrogenase CSC52_1896 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CSC52_1900 ENOG4105DCG PHP domain protein CSC52_1904 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CSC52_1906 ENOG4108RWN rrna methyltransferase CSC52_1908 ENOG4105KFN sortase, SrtB family CSC52_1919 ENOG4106H78 methyltransferase CSC52_1928 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CSC52_1929 ENOG4105CNI cell division protein FtsW CSC52_1933 ENOG4105CI3 gtp-binding protein typa CSC52_1935 ENOG4105ECY inositol monophosphatase CSC52_1940 ENOG4107RUE extracellular solute-binding protein family 1 CSC52_1941 ENOG4105D38 putrescine abc transporter CSC52_1942 ENOG4105F38 ABC transporter, permease CSC52_1946 ENOG4107QN2 dihydrolipoyl dehydrogenase CSC52_1947 ENOG4105C7S Dehydrogenase CSC52_1948 ENOG4105CPP Dehydrogenase, E1 component CSC52_1949 ENOG4107RUY (E1 component), alpha subunit CSC52_1951 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CSC52_1954 ENOG4107ZYR domain protein CSC52_1957 ENOG41067VN Glutaredoxin CSC52_1959 ENOG4105KRI phosphocarrier protein (HPr CSC52_1961 ENOG4105DR4 Methyltransferase CSC52_1964 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CSC52_1965 ENOG4108JJB ABC transporter CSC52_1966 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CSC52_1967 ENOG4105C12 Phosphoribosylglycinamide synthetase CSC52_1969 ENOG4108V3E phosphoribosylglycinamide formyltransferase CSC52_1971 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CSC52_1973 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CSC52_1974 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CSC52_1976 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CSC52_1977 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CSC52_1985 ENOG4108A04 Beta-lactamase CSC52_1986 ENOG4108KGH TRANSCRIPTIONal CSC52_1988 ENOG41082BV acetyltransferase CSC52_1991 ENOG4108TGC Acyltransferase CSC52_1992 ENOG4105CHM Aminotransferase CSC52_1993 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases CSC52_1996 ENOG4108IPT Naphthoate synthase CSC52_1997 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CSC52_1999 ENOG4105E4F Isochorismate synthase CSC52_2000 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CSC52_2001 ENOG41080E2 ribosomal-protein-alanine acetyltransferase CSC52_2002 ENOG4105YB8 TM2 domain containing protein CSC52_2004 ENOG4108HUF Transporter CSC52_2008 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CSC52_2015 ENOG4105XVF Competence transcription factor CSC52_2018 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CSC52_2020 ENOG4105C0H protease CSC52_2021 ENOG4107TS3 membrane protein, TerC CSC52_2027 ENOG4108PK2 permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence CSC52_2030 ENOG4105BZG amino acid carrier protein CSC52_2031 ENOG4105C02 permease CSC52_2034 ENOG4105CJW magnesium transporter CSC52_2035 ENOG4105EMS pseudouridine synthase CSC52_2040 ENOG4108Z18 K06886 hemoglobin CSC52_2041 ENOG4105T58 Dithiol-disulfide isomerase CSC52_2042 ENOG4105DPN Oligoendopeptidase f CSC52_2045 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CSC52_2046 ENOG4105C31 Tryptophanyl-tRNA synthetase CSC52_2047 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC52_2049 ENOG4108JQ7 (ABC) transporter CSC52_2051 ENOG4105DEF Extracellular solute-binding protein, family 5 CSC52_2053 ENOG4108JQ7 (ABC) transporter CSC52_2055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC52_2056 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC52_2058 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSC52_2062 ENOG4105KIS phospholipid-binding protein CSC52_2065 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CSC52_2067 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSC52_2068 ENOG4105EXC Acyl-transferase CSC52_2070 ENOG4108KP7 hydrolase CSC52_2076 ENOG4105C3F Signal peptidase i CSC52_2082 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CSC52_2083 ENOG4105D82 Glutamate dehydrogenase CSC52_2084 ENOG4105C8Y Acetylornithine aminotransferase CSC52_2085 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSC52_2086 ENOG41060GV RNA binding s1 domain protein CSC52_2097 ENOG4105KA0 thioesterase Superfamily protein CSC52_2099 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CSC52_2101 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CSC52_2105 ENOG41083MR nifu domain-containing protein CSC52_2106 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CSC52_2108 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CSC52_2117 ENOG4105MMD transcriptional regulator CSC52_2122 ENOG4105I3N Conserved Protein CSC52_2129 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase CSC52_2133 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CSC52_2162 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CSC52_2173 ENOG4106CVF DNA replication protein CSC52_2177 ENOG4108UUM single-stranded DNA-binding protein CSC52_2194 ENOG4108UNV SUF system FeS assembly protein, NifU family CSC52_2195 ENOG4105C9B Cysteine desulfurase CSC52_2196 ENOG4105JRK feS assembly protein SufD CSC52_2197 ENOG4105C3K feS assembly ATPase SufC CSC52_2200 ENOG4105D01 (LipO)protein CSC52_2201 ENOG4108UMI ABC transporter, permease CSC52_2202 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSC52_2205 ENOG4108XI2 Domain of unknown function (DUF1963) CSC52_2208 ENOG41080E8 Transcriptional regulator, Spx MgsR family CSC52_2209 ENOG4105SZ6 Thioredoxin CSC52_2214 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CSC52_2215 ENOG4105CVJ phosphoglycerate mutase CSC52_2222 ENOG4105VEQ Cold shock protein CSC52_2223 ENOG4107Y9E nuclease CSC52_2227 ENOG4106HV3 Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps CSC52_2227 ENOG4106HV3 Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps CSC52_2235 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CSC52_2237 ENOG4105XZU Preprotein translocase, subunit SecG CSC52_2240 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CSC52_2243 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSC52_2250 ENOG4105CHW UPF0052 protein CSC52_2253 ENOG4105C3M thioredoxin reductase CSC52_2255 ENOG4108S4C acetyltransferase CSC52_2258 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CSC52_2259 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CSC52_2262 ENOG41068JE domain protein CSC52_2266 ENOG41081UC Inherit from COG: Competence protein CSC52_2269 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CSC52_2270 ENOG4105ESV Glycosyl transferase, family 4 CSC52_2282 ENOG4108IPW abc transporter atp-binding protein CSC52_2283 ENOG4105CM4 permease protein CSC52_2284 ENOG4105DHS permease protein CSC52_2285 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSC52_2286 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSC52_2290 ENOG4105DUX Transporter CSC52_2292 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C CSC52_2294 ENOG4105E90 ABC transporter CSC52_2295 ENOG4108IJ8 ABC transporter CSC52_2296 ENOG4105C9U ATP-dependent DNA helicase RecQ CSC52_2297 ENOG4105C5H ABC transporter CSC52_2302 ENOG4105CRQ synthase (Component I) CSC52_2303 ENOG4105DDQ anthranilate synthase CSC52_2305 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CSC52_2306 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CSC52_2312 ENOG4105CKK Glycosyl transferase, family 2 CSC52_2314 ENOG4105C37 (CBS) domain CSC52_2315 ENOG4105CE4 GlcNAc 6-P deacetylase CSC52_2316 ENOG4105DM4 PTS System CSC52_2317 ENOG4105DE4 1-phosphofructokinase CSC52_2318 ENOG4105E98 transcriptional regulator DeoR family CSC52_2319 ENOG4108Z66 YbaK ebsC protein CSC52_2321 ENOG4105DP8 Major facilitator superfamily MFS_1 CSC52_2324 ENOG4105CVP deoxyribo-dipyrimidine photolyase CSC52_2325 ENOG4107QPK )-transporter CSC52_2327 ENOG4107QM2 Aldo Keto reductase CSC52_2328 ENOG4105CKI cobalamin synthesis protein CSC52_2329 ENOG41083AI transcriptional regulator), MarR family CSC52_2330 ENOG4108JJ8 (ABC) transporter CSC52_2331 ENOG4108JJ9 ABC, transporter CSC52_2335 ENOG4108URH decarboxylase CSC52_2336 ENOG4108YYQ gCN5-related N-acetyltransferase CSC52_2341 ENOG4105SXS Protein of unknown function (DUF456) CSC52_2342 ENOG4105S8Q sugar efflux transporter CSC52_2349 ENOG4105ID8 Transcriptional regulator, ARAC family CSC52_2351 ENOG4105VRS hydrolase family 18 CSC52_2352 ENOG4105CJ3 phosphate transporter CSC52_2353 ENOG4107GRR phosphate transport regulator CSC52_2355 ENOG4105C19 ABC transporter CSC52_2362 ENOG4108K88 Membrane CSC52_2364 ENOG4105VDH Dihydroxyacetone kinase CSC52_2366 ENOG4105CMT Dihydroxyacetone kinase CSC52_2367 ENOG4105EHG Permease protein CSC52_2368 ENOG4105DQ5 transport system permease protein CSC52_2369 ENOG4105E0A ABC, transporter CSC52_2370 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CSC52_2372 ENOG4105BZ1 (ABC) transporter CSC52_2374 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase CSC52_2378 ENOG4105EY8 ABC transporter CSC52_2379 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family CSC52_2381 ENOG4107R5H iron (metal) dependent repressor, dtxr family CSC52_2382 ENOG4105DIK (ABC) transporter CSC52_2383 ENOG4105CC5 ABC transporter CSC52_2384 ENOG4105DSE periplasmic solute binding protein CSC52_2388 ENOG4105EEQ Na H antiporter CSC52_2396 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off CSC52_2404 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CSC52_2406 ENOG4108IU2 vtamin B12-transporter permease CSC52_2407 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CSC52_2412 ENOG4108XFG YwhD family CSC52_2413 ENOG4105DCI Phosphohydrolase CSC52_2415 ENOG4108WS4 fmn reductase CSC52_2416 ENOG4105CPC Aldo Keto reductase CSC52_2421 ENOG4107QN2 dihydrolipoyl dehydrogenase CSC52_2425 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CSC52_2426 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CSC52_2427 ENOG4108IJ2 phosphate acetyltransferase CSC52_2435 ENOG4105DWF phosphomethylpyrimidine kinase CSC52_2444 ENOG4108VA3 3-hexulose-6-phosphate synthase CSC52_2447 ENOG4107YEI lmbE family CSC52_2452 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CSC52_2453 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CSC52_2455 ENOG410667J hydrolase CSC52_2456 ENOG4108Z6B deaminase CSC52_2458 ENOG4105ZMH deoxynucleoside kinase CSC52_2459 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CSC52_2460 ENOG4105CM2 brancheD-chain amino acid aminotransferase CSC52_2464 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CSC52_2471 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSC52_2473 ENOG4107Y49 methyltransferase CSC52_2478 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CSC52_2479 ENOG410683Z Preprotein translocase SecE subunit CSC52_2483 ENOG4105C2N RNA methyltransferase TrmH family group 3 CSC52_2484 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CSC52_2486 ENOG4105D7W serine acetyltransferase CSC52_2488 ENOG4105CTP PilT protein domain protein CSC52_2489 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CSC52_2492 ENOG4108Z0C Uvrb UvrC protein CSC52_2494 ENOG4105D9N nucleoside CSC52_2498 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSC52_2516 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CSC52_2517 ENOG4105KRF dihydroneopterin aldolase CSC52_2518 ENOG4105EEI dihydropteroate synthase CSC52_2519 ENOG4105C6T cysteine synthase CSC52_2521 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CSC52_2522 ENOG4108UGV hypoxanthine phosphoribosyltransferase CSC52_2523 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CSC52_2524 ENOG41060GV RNA binding s1 domain protein CSC52_2526 ENOG41082I2 s4 domain protein CSC52_2527 ENOG4108IY2 MazG family CSC52_2529 ENOG4108JA2 transcriptioN-repair coupling factor CSC52_2532 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CSC52_2533 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CSC52_2536 ENOG4105KME endoribonuclease L-psp CSC52_2537 ENOG4105DFT pur operon repressor CSC52_2539 ENOG4105W42 Veg protein CSC52_2541 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CSC52_2542 ENOG4105F8V Hydrolase, tatD family CSC52_2543 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CSC52_2544 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CSC52_2546 ENOG41060K3 Methyltransferase CSC52_2548 ENOG4105MA4 psp1 domain protein CSC52_2549 ENOG4105FA2 dna polymerase iii CSC52_2550 ENOG4105X0R protein from nitrogen regulatory protein P-II CSC52_2552 ENOG4105CXN decarboxylase CSC52_2557 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CSC52_2558 ENOG4105C6E dna polymerase iii CSC52_2560 ENOG4107414 GntR family transcriptional regulator CSC52_2561 ENOG4105CG3 alpha amylase, catalytic region CSC52_2562 ENOG4105C5Y PTS System CSC52_2564 ENOG4105BZ8 glutamate synthase CSC52_2565 ENOG4105CBC glutamate synthase CSC52_2566 ENOG4105C5Q Transcriptional regulator CSC52_2573 ENOG4105D01 (LipO)protein CSC52_2574 ENOG4108UMI ABC transporter, permease CSC52_2575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSC52_2576 ENOG4105C28 cystathionine CSC52_2578 ENOG4105C8J )-transporter CSC52_2582 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CSC52_2584 ENOG4108TWJ NADH dehydrogenase subunit 5 CSC52_2585 ENOG4105CKI cobalamin synthesis protein CSC52_2615 ENOG4105KA3 membrAne CSC52_2622 ENOG4105C2W permease CSC52_2627 ENOG4107R6U sodium dicarboxylate symporter CSC52_2628 ENOG4108DBC nitroreductase CSC52_2630 ENOG4108JU3 Alkyl hydroperoxide reductase CSC52_2644 ENOG4108UUM single-stranded DNA-binding protein CSC52_2647 ENOG4105C3G gtp-binding protein CSC52_2648 ENOG4105VDK protein, conserved in bacteria CSC52_2649 ENOG4105D8X mechanosensitive ion channel CSC52_2650 ENOG4105FA0 parb-like partition protein CSC52_2651 ENOG4105C28 cystathionine CSC52_2652 ENOG4105C28 cystathionine CSC52_2656 ENOG4105CHU acetyl-coa acetyltransferase CSC52_2659 ENOG4105CJ1 ABC, transporter CSC52_2661 ENOG4105VZ8 Transcriptional regulator CSC52_2663 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CSC52_2665 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CSC52_2666 ENOG4107SJW iron permease, FTR1 CSC52_2667 ENOG4105DBE peroxidase CSC52_2668 ENOG410650H (LipO)protein CSC52_2672 ENOG4107V0Z fmn reductase CSC52_2675 ENOG4105CXY transporter CSC52_2677 ENOG4105C3S Mate efflux family protein CSC52_2679 ENOG4105CID antiterminator CSC52_2680 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CSC52_2682 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CSC52_2683 ENOG4105CMR udp-glucose 4-epimerase CSC52_2686 ENOG4108UVJ appr-1-p processing domain protein CSC52_2688 ENOG4105DEN Luciferase family CSC52_2691 ENOG4105J1V Triacylglycerol lipase CSC52_2692 ENOG4105DWD nucleoside recognition domain protein CSC52_2694 ENOG4106KNT transcriptional regulator CSC52_2695 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) CSC52_2697 ENOG4107RJ1 sodium solute CSC52_2698 ENOG4105D9N nucleoside CSC52_2703 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CSC52_2704 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CSC52_2723 ENOG4105EC2 ftsk spoIIIe CSC52_2725 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) CSC52_2727 ENOG4106PAW secretion accessory protein EsaA YueB CSC52_2729 ENOG4105VRS hydrolase family 18 CSC52_2733 ENOG4105DA5 (ABC) transporter CSC52_2734 ENOG4105DR5 peptidase CSC52_2740 ENOG4105EV1 Ribose uptake protein RbsU CSC52_2743 ENOG4105DVA methyltransferase CSC52_2744 ENOG4105CS2 ec 3.2.1.21 CSC52_2745 ENOG4105CI1 PTS System CSC52_2753 ENOG4107RZX Teichoic acid biosynthesis protein CSC52_2754 ENOG4105EJJ Dehydrogenase CSC52_2756 ENOG4107SJB teichoic acid biosynthesis CSC52_2758 ENOG4107RZX Teichoic acid biosynthesis protein CSC52_2759 ENOG4105EJJ Dehydrogenase CSC52_2760 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CSC52_2761 ENOG4105CPQ Dehydrogenase CSC52_2763 ENOG4105CPQ Dehydrogenase CSC52_2764 ENOG4105DT3 PTS system, galactitol-specific IIc component CSC52_2765 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) CSC52_2768 ENOG4105DU0 nucleoside hydrolase CSC52_2769 ENOG4105CI1 PTS System CSC52_2774 ENOG4105K78 MarR family Transcriptional regulator CSC52_2775 ENOG4107RRN ABC transporter substrate-binding protein CSC52_2777 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) CSC52_2778 ENOG4105CEY Amp-dependent synthetase and ligase CSC52_2779 ENOG4105C1G acyl-Coa dehydrogenase CSC52_2780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CSC52_2781 ENOG4105CHU acetyl-coa acetyltransferase CSC52_2791 ENOG4105CXY transporter CSC52_2792 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase CSC52_2794 ENOG4105CK5 oxidoreductase CSC52_2796 ENOG4105EG2 ABC transporter, permease CSC52_2803 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CSC52_2805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSC52_2806 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSC52_2808 ENOG4105DA5 (ABC) transporter CSC52_2812 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CSC52_2813 ENOG4105C19 ABC transporter CSC52_2816 ENOG4105DZR Type I site-specific deoxyribonuclease CSC52_2817 ENOG4105QEK Transcriptional regulator CSC52_2822 ENOG4107RA9 decarboxylase CSC52_2823 ENOG4105D3W isochorismatase CSC52_2824 ENOG4105CWM branched-chain amino acid transport system II carrier protein CSC52_2825 ENOG4105C8Y Acetylornithine aminotransferase CSC52_2827 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CSC52_2834 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CSC52_2835 ENOG4105C1G acyl-Coa dehydrogenase CSC52_2841 ENOG4105PGM cation diffusion facilitator family transporter CSC52_2842 ENOG4105C26 Dehydrogenase CSC52_2843 ENOG4105WD1 Membrane CSC52_2845 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CSC52_2848 ENOG4105D3Q Sugar transferase CSC52_2854 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CSC52_2856 ENOG4105C5E polysaccharide biosynthesis protein CSC52_2861 ENOG4108EKI Dehydrogenase CSC52_2864 ENOG4105CGH 5'-nucleotidase CSC52_2871 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CSC52_2872 ENOG4108J8C transporter major facilitator family protein CSC52_2873 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CSC52_2879 ENOG4105CPK Glycosyl transferase (Group 1 CSC52_2881 ENOG4108IAJ Nad-dependent epimerase dehydratase CSC52_2883 ENOG4105CHR reductase