locus-tag class description DQV29_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DQV29_00015 ENOG410848D S4 domain protein YaaA DQV29_00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DQV29_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DQV29_00035 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DQV29_00065 ENOG4105DWV Homoserine O-trans-acetylase DQV29_00075 ENOG4105BZR domain protein DQV29_00085 ENOG4105CDU Replicative dna helicase DQV29_00095 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DQV29_00130 ENOG4105Q2H domain protein DQV29_00135 ENOG4105CGH 5'-nucleotidase DQV29_00200 ENOG4105C2M dna polymerase I DQV29_00240 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DQV29_00250 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DQV29_00255 ENOG4108ZMQ domain protein DQV29_00260 ENOG4107RVG penicillin-binding protein DQV29_00265 ENOG4105CCN Peptidase M56 DQV29_00290 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DQV29_00295 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DQV29_00300 ENOG4105XTG Pfam:DUF156 DQV29_00305 ENOG41087NI Sulfite exporter TauE/SafE DQV29_00315 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DQV29_00330 ENOG41071EZ rRNA adenine N-6-methyltransferase DQV29_00335 ENOG4106JUT Streptomycin 3''-adenylyltransferase DQV29_00340 ENOG4105ZX1 Transposase C DQV29_00345 ENOG4108KU9 integrase family DQV29_00350 ENOG4108FPN Integrase DQV29_00355 ENOG410826E Dna repair protein radc DQV29_00410 ENOG4105EEX Two component transcriptional regulator (Winged helix family DQV29_00415 ENOG4105C08 Histidine kinase DQV29_00425 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DQV29_00430 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DQV29_00435 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) DQV29_00490 ENOG41087NI Sulfite exporter TauE/SafE DQV29_00495 ENOG4105XTG Pfam:DUF156 DQV29_00500 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DQV29_00505 ENOG4105C5X domain protein DQV29_00525 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DQV29_00600 ENOG4105C57 major facilitator superfamily DQV29_00610 ENOG4105CCI Myosin-Cross-Reactive Antigen DQV29_00615 ENOG4107Y9U Membrane DQV29_00650 ENOG4108IHU transport system permease protein DQV29_00655 ENOG4105DQ5 transport system permease protein DQV29_00660 ENOG4108MES Periplasmic binding protein DQV29_00670 ENOG4105CIF Ornithine Cyclodeaminase DQV29_00675 ENOG4105DJU Siderophore biosynthesis protein DQV29_00680 ENOG4105C6X Major Facilitator DQV29_00685 ENOG4105DBM Siderophore biosynthesis protein DQV29_00690 ENOG4105DUU IucA IucC family protein DQV29_00700 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DQV29_00705 ENOG41067FT ParB-like nuclease domain DQV29_00720 ENOG4105CHR reductase DQV29_00730 ENOG4108IAJ Nad-dependent epimerase dehydratase DQV29_00740 ENOG4105CPK Glycosyl transferase (Group 1 DQV29_00775 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DQV29_00780 ENOG4108J8C transporter major facilitator family protein DQV29_00785 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DQV29_00820 ENOG4105CGH 5'-nucleotidase DQV29_00835 ENOG4108EKI Dehydrogenase DQV29_00860 ENOG4105C5E polysaccharide biosynthesis protein DQV29_00870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DQV29_00900 ENOG4105D3Q Sugar transferase DQV29_00915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DQV29_00925 ENOG4105WD1 Membrane DQV29_00930 ENOG4105C26 Dehydrogenase DQV29_00935 ENOG4105PGM cation diffusion facilitator family transporter DQV29_00965 ENOG4105C1G acyl-Coa dehydrogenase DQV29_00970 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DQV29_01005 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DQV29_01015 ENOG4105C8Y Acetylornithine aminotransferase DQV29_01020 ENOG4105CWM branched-chain amino acid transport system II carrier protein DQV29_01025 ENOG4105D3W isochorismatase DQV29_01030 ENOG4107RA9 decarboxylase DQV29_01060 ENOG4105QEK Transcriptional regulator DQV29_01070 ENOG4105DZR Type I site-specific deoxyribonuclease DQV29_01085 ENOG4105C19 ABC transporter DQV29_01090 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DQV29_01110 ENOG4105DA5 (ABC) transporter DQV29_01125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DQV29_01130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DQV29_01140 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DQV29_01175 ENOG4105EG2 ABC transporter, permease DQV29_01185 ENOG4105CK5 oxidoreductase DQV29_01195 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase DQV29_01200 ENOG4105CXY transporter DQV29_01250 ENOG4105CHU acetyl-coa acetyltransferase DQV29_01255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DQV29_01260 ENOG4105C1G acyl-Coa dehydrogenase DQV29_01265 ENOG4105CEY Amp-dependent synthetase and ligase DQV29_01270 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) DQV29_01280 ENOG4107RRN ABC transporter substrate-binding protein DQV29_01285 ENOG4105K78 MarR family Transcriptional regulator DQV29_01320 ENOG4105CI1 PTS System DQV29_01325 ENOG4105DU0 nucleoside hydrolase DQV29_01345 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DQV29_01350 ENOG4105DT3 PTS system, galactitol-specific IIc component DQV29_01355 ENOG4105CPQ Dehydrogenase DQV29_01365 ENOG4105CPQ Dehydrogenase DQV29_01370 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DQV29_01375 ENOG4105EJJ Dehydrogenase DQV29_01380 ENOG4107RZX Teichoic acid biosynthesis protein DQV29_01385 ENOG4107SJB teichoic acid biosynthesis DQV29_01395 ENOG4105EJJ Dehydrogenase DQV29_01400 ENOG4107RZX Teichoic acid biosynthesis protein DQV29_01445 ENOG4105CI1 PTS System DQV29_01450 ENOG4105CS2 ec 3.2.1.21 DQV29_01460 ENOG4105DVA methyltransferase DQV29_01480 ENOG4105EV1 Ribose uptake protein RbsU DQV29_01510 ENOG4105DR5 peptidase DQV29_01515 ENOG4105DA5 (ABC) transporter DQV29_01535 ENOG4105VRS hydrolase family 18 DQV29_01545 ENOG4106PAW secretion accessory protein EsaA YueB DQV29_01555 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DQV29_01565 ENOG4105EC2 ftsk spoIIIe DQV29_01665 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DQV29_01675 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DQV29_01705 ENOG4105D9N nucleoside DQV29_01710 ENOG4107RJ1 sodium solute DQV29_01720 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) DQV29_01725 ENOG4106KNT transcriptional regulator DQV29_01735 ENOG4105DWD nucleoside recognition domain protein DQV29_01740 ENOG4105J1V Triacylglycerol lipase DQV29_01760 ENOG4105DEN Luciferase family DQV29_01770 ENOG4108UVJ appr-1-p processing domain protein DQV29_01785 ENOG4105CMR udp-glucose 4-epimerase DQV29_01790 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC DQV29_01800 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia DQV29_01805 ENOG4105CID antiterminator DQV29_01820 ENOG4105C3S Mate efflux family protein DQV29_01830 ENOG4105CXY transporter DQV29_01845 ENOG4107V0Z fmn reductase DQV29_01865 ENOG410650H (LipO)protein DQV29_01870 ENOG4105DBE peroxidase DQV29_01875 ENOG4107SJW iron permease, FTR1 DQV29_01880 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DQV29_01885 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DQV29_01895 ENOG4105VZ8 Transcriptional regulator DQV29_01905 ENOG4105CJ1 ABC, transporter DQV29_01920 ENOG4105CHU acetyl-coa acetyltransferase DQV29_01940 ENOG4105C28 cystathionine DQV29_01945 ENOG4105C28 cystathionine DQV29_01955 ENOG4105FA0 parb-like partition protein DQV29_01960 ENOG4105D8X mechanosensitive ion channel DQV29_01965 ENOG4105VDK protein, conserved in bacteria DQV29_01970 ENOG4105C3G gtp-binding protein DQV29_01990 ENOG4108UUM single-stranded DNA-binding protein DQV29_02060 ENOG4108JU3 Alkyl hydroperoxide reductase DQV29_02070 ENOG4108DBC nitroreductase DQV29_02075 ENOG4107R6U sodium dicarboxylate symporter DQV29_02110 ENOG4105C2W permease DQV29_02150 ENOG4105KA3 membrAne DQV29_02310 ENOG4105CKI cobalamin synthesis protein DQV29_02335 ENOG4108TWJ NADH dehydrogenase subunit 5 DQV29_02345 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DQV29_02365 ENOG4105C8J )-transporter DQV29_02375 ENOG4105C28 cystathionine DQV29_02380 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DQV29_02385 ENOG4108UMI ABC transporter, permease DQV29_02390 ENOG4105D01 (LipO)protein DQV29_02425 ENOG4105C5Q Transcriptional regulator DQV29_02430 ENOG4105CBC glutamate synthase DQV29_02435 ENOG4105BZ8 glutamate synthase DQV29_02445 ENOG4105C5Y PTS System DQV29_02450 ENOG4105CG3 alpha amylase, catalytic region DQV29_02455 ENOG4107414 GntR family transcriptional regulator DQV29_02475 ENOG4105C6E dna polymerase iii DQV29_02480 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DQV29_02515 ENOG4105CXN decarboxylase DQV29_02525 ENOG4105X0R protein from nitrogen regulatory protein P-II DQV29_02530 ENOG4105FA2 dna polymerase iii DQV29_02535 ENOG4105MA4 psp1 domain protein DQV29_02545 ENOG41060K3 Methyltransferase DQV29_02555 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DQV29_02560 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DQV29_02565 ENOG4105F8V Hydrolase, tatD family DQV29_02570 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DQV29_02580 ENOG4105W42 Veg protein DQV29_02590 ENOG4105DFT pur operon repressor DQV29_02595 ENOG4105KME endoribonuclease L-psp DQV29_02610 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DQV29_02615 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DQV29_02635 ENOG4108JA2 transcriptioN-repair coupling factor DQV29_02645 ENOG4108IY2 MazG family DQV29_02650 ENOG41082I2 s4 domain protein DQV29_02660 ENOG41060GV RNA binding s1 domain protein DQV29_02665 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DQV29_02670 ENOG4108UGV hypoxanthine phosphoribosyltransferase DQV29_02675 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DQV29_02685 ENOG4105C6T cysteine synthase DQV29_02690 ENOG4105EEI dihydropteroate synthase DQV29_02695 ENOG4105KRF dihydroneopterin aldolase DQV29_02700 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DQV29_02790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DQV29_02805 ENOG4105D9N nucleoside DQV29_02815 ENOG4108Z0C Uvrb UvrC protein DQV29_02830 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DQV29_02835 ENOG4105CTP PilT protein domain protein DQV29_02860 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DQV29_02865 ENOG4105C2N RNA methyltransferase TrmH family group 3 DQV29_02885 ENOG410683Z Preprotein translocase SecE subunit DQV29_02890 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DQV29_02920 ENOG4107Y49 methyltransferase DQV29_02930 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DQV29_02965 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DQV29_02985 ENOG4105CM2 brancheD-chain amino acid aminotransferase DQV29_02990 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DQV29_02995 ENOG4105ZMH deoxynucleoside kinase DQV29_03005 ENOG4108Z6B deaminase DQV29_03010 ENOG410667J hydrolase DQV29_03025 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein DQV29_03030 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein DQV29_03055 ENOG4107YEI lmbE family DQV29_03070 ENOG4108VA3 3-hexulose-6-phosphate synthase DQV29_03120 ENOG4105DWF phosphomethylpyrimidine kinase DQV29_03165 ENOG4108IJ2 phosphate acetyltransferase DQV29_03170 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DQV29_03175 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DQV29_03195 ENOG4107QN2 dihydrolipoyl dehydrogenase DQV29_03230 ENOG4105CPC Aldo Keto reductase DQV29_03240 ENOG4108WS4 fmn reductase DQV29_03250 ENOG4105DCI Phosphohydrolase DQV29_03255 ENOG4108XFG YwhD family DQV29_03285 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DQV29_03290 ENOG4108IU2 vtamin B12-transporter permease DQV29_03300 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DQV29_03315 ENOG4108MEZ Alpha beta hydrolase DQV29_03340 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off DQV29_03380 ENOG4105EEQ Na H antiporter DQV29_03395 ENOG4105DSE periplasmic solute binding protein DQV29_03400 ENOG4105CC5 ABC transporter DQV29_03405 ENOG4105DIK (ABC) transporter DQV29_03410 ENOG4107R5H iron (metal) dependent repressor, dtxr family DQV29_03420 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family DQV29_03425 ENOG4105EY8 ABC transporter DQV29_03445 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase DQV29_03455 ENOG4105BZ1 (ABC) transporter DQV29_03470 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DQV29_03475 ENOG4105E0A ABC, transporter DQV29_03480 ENOG4105DQ5 transport system permease protein DQV29_03485 ENOG4105EHG Permease protein DQV29_03490 ENOG4105CMT Dihydroxyacetone kinase DQV29_03500 ENOG4105VDH Dihydroxyacetone kinase DQV29_03510 ENOG4108K88 Membrane DQV29_03550 ENOG4105C19 ABC transporter DQV29_03565 ENOG4107GRR phosphate transport regulator DQV29_03570 ENOG4105CJ3 phosphate transporter DQV29_03575 ENOG4105VRS hydrolase family 18 DQV29_03585 ENOG4105ID8 Transcriptional regulator, ARAC family DQV29_03620 ENOG4105S8Q sugar efflux transporter DQV29_03625 ENOG4105SXS Protein of unknown function (DUF456) DQV29_03650 ENOG4108YYQ gCN5-related N-acetyltransferase DQV29_03655 ENOG4108URH decarboxylase DQV29_03675 ENOG4108JJ9 ABC, transporter DQV29_03680 ENOG4108JJ8 (ABC) transporter DQV29_03685 ENOG41083AI transcriptional regulator), MarR family DQV29_03690 ENOG4105CKI cobalamin synthesis protein DQV29_03695 ENOG4107QM2 Aldo Keto reductase DQV29_03705 ENOG4107QPK )-transporter DQV29_03710 ENOG4105CVP deoxyribo-dipyrimidine photolyase DQV29_03730 ENOG4105DP8 Major facilitator superfamily MFS_1 DQV29_03740 ENOG4108Z66 YbaK ebsC protein DQV29_03745 ENOG4105E98 transcriptional regulator DeoR family DQV29_03750 ENOG4105DE4 1-phosphofructokinase DQV29_03755 ENOG4105DM4 PTS System DQV29_03760 ENOG4105CE4 GlcNAc 6-P deacetylase DQV29_03765 ENOG4105C37 (CBS) domain DQV29_03775 ENOG4105CKK Glycosyl transferase, family 2 DQV29_03805 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DQV29_03810 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DQV29_03820 ENOG4105DDQ anthranilate synthase DQV29_03825 ENOG4105CRQ synthase (Component I) DQV29_03855 ENOG4105C5H ABC transporter DQV29_03860 ENOG4105C9U ATP-dependent DNA helicase RecQ DQV29_03865 ENOG4108IJ8 ABC transporter DQV29_03870 ENOG4105E90 ABC transporter DQV29_03880 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C DQV29_03905 ENOG4105DUX Transporter DQV29_03935 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DQV29_03940 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DQV29_03950 ENOG4105DHS permease protein DQV29_03955 ENOG4105CM4 permease protein DQV29_03960 ENOG4108IPW abc transporter atp-binding protein DQV29_04020 ENOG4105ESV Glycosyl transferase, family 4 DQV29_04025 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DQV29_04040 ENOG41081UC Inherit from COG: Competence protein DQV29_04070 ENOG41068JE domain protein DQV29_04085 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DQV29_04090 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DQV29_04105 ENOG4108S4C acetyltransferase DQV29_04115 ENOG4105C3M thioredoxin reductase DQV29_04130 ENOG4105CHW UPF0052 protein DQV29_04170 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DQV29_04185 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DQV29_04200 ENOG4105XZU Preprotein translocase, subunit SecG DQV29_04210 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DQV29_04260 ENOG4106HV3 Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps DQV29_04260 ENOG4106HV3 Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps DQV29_04280 ENOG4107Y9E nuclease DQV29_04285 ENOG4105VEQ Cold shock protein DQV29_04325 ENOG4105CVJ phosphoglycerate mutase DQV29_04330 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DQV29_04355 ENOG4105SZ6 Thioredoxin DQV29_04360 ENOG41080E8 Transcriptional regulator, Spx MgsR family DQV29_04375 ENOG4108XI2 Domain of unknown function (DUF1963) DQV29_04395 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DQV29_04400 ENOG4108UMI ABC transporter, permease DQV29_04405 ENOG4105D01 (LipO)protein DQV29_04420 ENOG4105C3K feS assembly ATPase SufC DQV29_04425 ENOG4105JRK feS assembly protein SufD DQV29_04430 ENOG4105C9B Cysteine desulfurase DQV29_04435 ENOG4108UNV SUF system FeS assembly protein, NifU family DQV29_04525 ENOG4108UUM single-stranded DNA-binding protein DQV29_04545 ENOG4106CVF DNA replication protein DQV29_04600 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DQV29_04755 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis DQV29_04775 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase DQV29_04825 ENOG4105EY8 ABC transporter DQV29_04840 ENOG41067AE Membrane-bound metal-dependent hydrolase DQV29_04865 ENOG4107NBY Membrane DQV29_04875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DQV29_04880 ENOG4108M3J Dehydrogenase DQV29_04885 ENOG4105G5W regulator Fur family DQV29_05050 ENOG4105E5Q amino acid AbC transporter DQV29_05055 ENOG4105CDA abc transporter atp-binding protein DQV29_05060 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DQV29_05085 ENOG4105C9Q fumarate hydratase class II DQV29_05090 ENOG4108YBP pseudouridine synthase DQV29_05095 ENOG4105BZU Histidine kinase DQV29_05100 ENOG4105WH1 Two component transcriptional regulator luxr family DQV29_05130 ENOG4107VRP DNA repair exonuclease DQV29_05160 ENOG4105K59 histidine triad (HIT) protein DQV29_05195 ENOG4105C1Q protoporphyrinogen oxidase DQV29_05450 ENOG4105E09 nadh pyrophosphatase DQV29_05475 ENOG4105CV8 reductase DQV29_05485 ENOG4105WMR Protein CrcB homolog DQV29_05490 ENOG4106A8V Protein CrcB homolog DQV29_05500 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DQV29_05530 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis DQV29_05535 ENOG4107R3E Citrate transporter DQV29_05550 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DQV29_05555 ENOG4108R6K riboflavin synthase, subunit alpha DQV29_05560 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DQV29_05585 ENOG4105E8V Alpha Beta Hydrolase Fold protein DQV29_05600 ENOG4105N5T Radical SAM Protein DQV29_05605 ENOG410605W Major Facilitator DQV29_05625 ENOG4105CBX hi0933 family DQV29_05650 ENOG4105F0I Aminotransferase DQV29_05655 ENOG4108V15 phosphotransferase enzyme family DQV29_05665 ENOG4105C8F Beta-lactamase domain protein DQV29_05690 ENOG4108VDD TRNA binding domain protein DQV29_05720 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DQV29_05730 ENOG4105ETE Transcriptional regulator (LacI family DQV29_05735 ENOG4105DGU Histone deacetylase DQV29_05740 ENOG4105F1V Acetoin utilization protein DQV29_05780 ENOG4105C0H protease DQV29_05785 ENOG4105F6E Acyl-transferase DQV29_05805 ENOG4108JQ1 Dehydrogenase DQV29_05810 ENOG4105C5R Aminotransferase DQV29_05815 ENOG4108X3M OsmC Ohr family protein DQV29_05820 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DQV29_05865 ENOG4105EJ9 Membrane DQV29_05870 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DQV29_05920 ENOG4105SFS phosphoesterase RecJ domain protein DQV29_05925 ENOG4105C0B DNA polymerase III (alpha subunit) DQV29_05930 ENOG4105C6K Malic enzyme DQV29_05955 ENOG4105C85 amino acid DQV29_05960 ENOG4105BZN citrate synthase DQV29_05965 ENOG4108HMX isocitrate dehydrogenase (NADP) DQV29_05975 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DQV29_05980 ENOG4105BZU Histidine kinase DQV29_05990 ENOG4105C2M dna polymerase I DQV29_05995 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DQV29_06005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DQV29_06035 ENOG4108IQI permease DQV29_06060 ENOG4105U6W MutT NUDIX family protein DQV29_06110 ENOG4105D52 delta-aminolevulinic acid dehydratase DQV29_06130 ENOG4108R3E Dna-3-methyladenine glycosylase i DQV29_06140 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DQV29_06150 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) DQV29_06160 ENOG4108FPN Integrase DQV29_06165 ENOG4108KU9 integrase family DQV29_06170 ENOG4105ZX1 Transposase C DQV29_06175 ENOG4106JUT Streptomycin 3''-adenylyltransferase DQV29_06180 ENOG41071EZ rRNA adenine N-6-methyltransferase DQV29_06195 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DQV29_06240 ENOG4105X36 (ribosomal) protein DQV29_06280 ENOG4105VIE preprotein translocase, subunit YajC DQV29_06285 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DQV29_06290 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DQV29_06335 ENOG4105CUZ uba thif-type nad fad binding protein DQV29_06340 ENOG4105D1H recombination factor protein RarA DQV29_06360 ENOG4105DEN Luciferase family DQV29_06365 ENOG4105C3J Cysteine desulfurase DQV29_06390 ENOG4105C7H Helicase, RecD TraA family DQV29_06420 ENOG4105XYU peptidase (U32 family) DQV29_06425 ENOG4105CFP Peptidase U32 DQV29_06440 ENOG4105P4J Allophanate hydrolase, subunit 1 DQV29_06450 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DQV29_06455 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DQV29_06465 ENOG4105C5A transporter DQV29_06505 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DQV29_06510 ENOG4105CQW ribosome biogenesis GTPase YqeH DQV29_06520 ENOG410812S Rna-binding protein DQV29_06530 ENOG4108WF2 Metal Dependent Phosphohydrolase DQV29_06535 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) DQV29_06540 ENOG4105DXX methyltransferase DQV29_06545 ENOG4105BZM domain protein DQV29_06550 ENOG4108UK2 deaminase DQV29_06555 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 DQV29_06560 ENOG4105TQK DNA polymerase iii, delta' subunit DQV29_06575 ENOG4105CSA Coproporphyrinogen iii oxidase DQV29_06605 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DQV29_06610 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DQV29_06620 ENOG4105F7J membrane-bound serine protease DQV29_06635 ENOG4105C9A Phoh family DQV29_06650 ENOG4105KG3 cytidine deaminase DQV29_06680 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DQV29_06685 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DQV29_06695 ENOG4105EGD dinuclear metal center protein, YbgI family DQV29_06700 ENOG4105C1J atp-dependent rna helicase DQV29_06710 ENOG4105FDK ABC transporter DQV29_06715 ENOG4105FAV ABC, transporter DQV29_06720 ENOG4105N80 Ferric uptake regulator, Fur family DQV29_06730 ENOG4107RF6 penicillin-binding protein DQV29_06740 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DQV29_06765 ENOG4105C5X domain protein DQV29_06775 ENOG4105D7Q type ii secretion system DQV29_06780 ENOG4106855 Competence protein DQV29_06825 ENOG4105WZW rhodanese family DQV29_06830 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DQV29_06845 ENOG4105DC7 peptidase M24 DQV29_06860 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DQV29_06865 ENOG4108ZSR alkaline shock protein DQV29_06895 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DQV29_06910 ENOG4105CPP Dehydrogenase, E1 component DQV29_06915 ENOG4105C7S Dehydrogenase DQV29_06925 ENOG4108QEG Membrane DQV29_06935 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DQV29_06940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DQV29_06975 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DQV29_06985 ENOG4105II7 pyrroline-5-carboxylate reductase DQV29_06990 ENOG4105PDP Short chain dehydrogenase DQV29_07000 ENOG4105CPC Aldo Keto reductase DQV29_07005 ENOG4108YZ4 nudix hydrolase DQV29_07010 ENOG4105I3K Ferric uptake regulator, Fur family DQV29_07015 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DQV29_07035 ENOG4105FE9 pseudouridine synthase DQV29_07040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DQV29_07045 ENOG4105BZU Histidine kinase DQV29_07265 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DQV29_07315 ENOG4108FKH Transglycosylase SLT domain DQV29_07365 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase DQV29_07420 ENOG4105C9U ATP-dependent DNA helicase RecQ DQV29_07425 ENOG4106BU8 elastin-binding protein ebpS DQV29_07435 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DQV29_07440 ENOG4105HDK L-asparaginase DQV29_07465 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DQV29_07480 ENOG4105K70 DNA-binding protein DQV29_07500 ENOG4105EAH synthase DQV29_07550 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DQV29_07555 ENOG4105CPK Glycosyl transferase (Group 1 DQV29_07585 ENOG4105CSM endonuclease III DQV29_07595 ENOG4105BZ4 penicillin-binding protein DQV29_07635 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DQV29_07650 ENOG410890F Dynamin family DQV29_07665 ENOG4105C7B Threonine dehydratase DQV29_07670 ENOG4107R7I amino acid DQV29_07725 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DQV29_07735 ENOG4108FKN Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DQV29_07745 ENOG4105C5Y PTS System DQV29_07755 ENOG4105CN1 protease DQV29_07770 ENOG410841Q phosphoesterase PA-phosphatase related protein DQV29_07800 ENOG4105C7S Dehydrogenase DQV29_07820 ENOG4107T89 von Willebrand factor, type A DQV29_07865 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DQV29_07870 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DQV29_07895 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DQV29_07900 ENOG4105CFH Aspartokinase DQV29_07910 ENOG4105C5H ABC transporter DQV29_07930 ENOG4105C8U phosphate abc transporter DQV29_07935 ENOG4105E2Z phosphate ABC transporter (Permease DQV29_07945 ENOG4108UTW Plays a role in the regulation of phosphate uptake DQV29_07950 ENOG4105DPN Oligoendopeptidase f DQV29_07965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DQV29_07970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DQV29_07980 ENOG4108JMM (ABC) transporter DQV29_07990 ENOG4108KP7 hydrolase DQV29_08000 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) DQV29_08005 ENOG4108RMH femAB family DQV29_08035 ENOG4105DDQ anthranilate synthase DQV29_08040 ENOG4105CRQ synthase (Component I) DQV29_08045 ENOG4105DER m42 family DQV29_08050 ENOG4105EVN Prephenate dehydrogenase DQV29_08055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DQV29_08065 ENOG4108RCF TRANSCRIPTIONal DQV29_08070 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DQV29_08075 ENOG4105FF5 Membrane DQV29_08105 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DQV29_08110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DQV29_08140 ENOG4108I0Z Aconitate hydratase DQV29_08150 ENOG4105C94 Transporter DQV29_08185 ENOG4105CV1 Transketolase (EC 2.2.1.1) DQV29_08205 ENOG4105K4I Scp-like extracellular DQV29_08235 ENOG4108IQI permease DQV29_08260 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DQV29_08265 ENOG4105D6E homoserine dehydrogenase DQV29_08270 ENOG4105CFH Aspartokinase DQV29_08295 ENOG4108S01 response regulator DQV29_08310 ENOG4108M15 ABC transporter DQV29_08315 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DQV29_08390 ENOG4105C5F glutamine synthetase DQV29_08395 ENOG4105KV4 Transcriptional regulator DQV29_08400 ENOG4105CXI aluminum resistance protein DQV29_08410 ENOG4108V06 Glutathione peroxidase DQV29_08415 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DQV29_08440 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DQV29_08445 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DQV29_08480 ENOG4105DQU oxidoreductase, subunit beta DQV29_08485 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DQV29_08490 ENOG4105D48 metallophosphoesterase DQV29_08510 ENOG4105CEV competence damage-inducible protein DQV29_08515 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DQV29_08530 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DQV29_08545 ENOG4105FDP GntR family transcriptional regulator DQV29_08550 ENOG4105CNU cell division protein FtsK DQV29_08575 ENOG4105DTN riboflavin biosynthesis protein ribF DQV29_08600 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DQV29_08605 ENOG4105CHV Transcription elongation factor NusA DQV29_08635 ENOG4105KNE Phosphatidate cytidylyltransferase DQV29_08640 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DQV29_08700 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DQV29_08705 ENOG4105C79 DNA protecting protein DprA DQV29_08710 ENOG4105C79 DNA protecting protein DprA DQV29_08715 ENOG4108RMH femAB family DQV29_08725 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DQV29_08740 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DQV29_08780 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DQV29_08785 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DQV29_08805 ENOG4105CHR reductase DQV29_08810 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DQV29_08825 ENOG4105CB5 ATP-dependent DNA helicase recG DQV29_08835 ENOG4108ZAA Alkaline-shock protein DQV29_08850 ENOG4105DJV ribulose-phosphate 3-epimerase DQV29_08855 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DQV29_08865 ENOG4108ZF3 Phosphatase DQV29_08875 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DQV29_08885 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DQV29_08890 ENOG4105YB8 TM2 domain containing protein DQV29_08900 ENOG4105C25 Primosomal protein n' DQV29_08905 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DQV29_08915 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DQV29_08920 ENOG4105F23 Fibronectin-binding protein DQV29_08935 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DQV29_08950 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DQV29_08955 ENOG4105CD3 dihydroorotase DQV29_08975 ENOG4105C34 Pseudouridine synthase DQV29_08995 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DQV29_09010 ENOG4105DBK s4 domain protein DQV29_09015 ENOG41067XK integral membrane protein DQV29_09025 ENOG4105DFA alanine racemase domain protein DQV29_09030 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DQV29_09035 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DQV29_09040 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DQV29_09045 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DQV29_09060 ENOG4105CJN penicillin-binding protein DQV29_09065 ENOG41068DC Essential cell division protein (By similarity) DQV29_09125 ENOG4105CSX c4-dicarboxylate anaerobic carrier DQV29_09135 ENOG4105DBV ornithine carbamoyltransferase DQV29_09170 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity DQV29_09245 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DQV29_09255 ENOG4105E33 succinate dehydrogenase DQV29_09265 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DQV29_09290 ENOG4105DCG PHP domain protein DQV29_09325 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DQV29_09335 ENOG4108RWN rrna methyltransferase DQV29_09350 ENOG4105KFN sortase, SrtB family DQV29_09410 ENOG4106H78 methyltransferase DQV29_09460 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DQV29_09465 ENOG4105CNI cell division protein FtsW DQV29_09485 ENOG4105CI3 gtp-binding protein typa DQV29_09495 ENOG4105ECY inositol monophosphatase DQV29_09520 ENOG4107RUE extracellular solute-binding protein family 1 DQV29_09525 ENOG4105D38 putrescine abc transporter DQV29_09530 ENOG4105F38 ABC transporter, permease DQV29_09550 ENOG4107QN2 dihydrolipoyl dehydrogenase DQV29_09555 ENOG4105C7S Dehydrogenase DQV29_09560 ENOG4105CPP Dehydrogenase, E1 component DQV29_09565 ENOG4107RUY (E1 component), alpha subunit DQV29_09575 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DQV29_09595 ENOG4107ZYR domain protein DQV29_09610 ENOG41067VN Glutaredoxin DQV29_09620 ENOG4105KRI phosphocarrier protein (HPr DQV29_09630 ENOG4105DR4 Methyltransferase DQV29_09655 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DQV29_09660 ENOG4108JJB ABC transporter DQV29_09665 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DQV29_09670 ENOG4105C12 Phosphoribosylglycinamide synthetase DQV29_09680 ENOG4108V3E phosphoribosylglycinamide formyltransferase DQV29_09690 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DQV29_09700 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DQV29_09705 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DQV29_09715 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DQV29_09720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DQV29_09760 ENOG4108A04 Beta-lactamase DQV29_09765 ENOG4108KGH TRANSCRIPTIONal DQV29_09775 ENOG41082BV acetyltransferase DQV29_09795 ENOG4108TGC Acyltransferase DQV29_09800 ENOG4105CHM Aminotransferase DQV29_09805 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases DQV29_09820 ENOG4108IPT Naphthoate synthase DQV29_09825 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DQV29_09835 ENOG4105E4F Isochorismate synthase DQV29_09845 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DQV29_09850 ENOG41080E2 ribosomal-protein-alanine acetyltransferase DQV29_09855 ENOG4105YB8 TM2 domain containing protein DQV29_09865 ENOG4108HUF Transporter DQV29_09885 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DQV29_09935 ENOG4105XVF Competence transcription factor DQV29_09950 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic DQV29_09960 ENOG4105C0H protease DQV29_09965 ENOG4107TS3 membrane protein, TerC DQV29_09990 ENOG4108PK2 permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence DQV29_10005 ENOG4105BZG amino acid carrier protein DQV29_10010 ENOG4105C02 permease DQV29_10025 ENOG4105CJW magnesium transporter DQV29_10030 ENOG4105EMS pseudouridine synthase DQV29_10055 ENOG4108Z18 K06886 hemoglobin DQV29_10060 ENOG4105T58 Dithiol-disulfide isomerase DQV29_10065 ENOG4105DPN Oligoendopeptidase f DQV29_10080 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DQV29_10085 ENOG4105C31 Tryptophanyl-tRNA synthetase DQV29_10090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DQV29_10100 ENOG4108JQ7 (ABC) transporter DQV29_10110 ENOG4105DEF Extracellular solute-binding protein, family 5 DQV29_10120 ENOG4108JQ7 (ABC) transporter DQV29_10130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DQV29_10135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DQV29_10145 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DQV29_10165 ENOG4105KIS phospholipid-binding protein DQV29_10180 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DQV29_10195 ENOG4105EXC Acyl-transferase DQV29_10205 ENOG4108KP7 hydrolase DQV29_10235 ENOG4105C3F Signal peptidase i DQV29_10265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DQV29_10270 ENOG4105D82 Glutamate dehydrogenase DQV29_10275 ENOG4105C8Y Acetylornithine aminotransferase DQV29_10280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DQV29_10285 ENOG41060GV RNA binding s1 domain protein DQV29_10340 ENOG4105KA0 thioesterase Superfamily protein DQV29_10350 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DQV29_10360 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DQV29_10380 ENOG41083MR nifu domain-containing protein DQV29_10385 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DQV29_10395 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DQV29_10445 ENOG4105MMD transcriptional regulator DQV29_10465 ENOG4105I3N Conserved Protein DQV29_10520 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase DQV29_10540 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis DQV29_10650 ENOG4105IG6 Phage terminase, large subunit DQV29_10695 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DQV29_10805 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DQV29_10815 ENOG4108S4H thioesterase Superfamily protein DQV29_10840 ENOG4107U9T Pfam:Ribonuclease_BN DQV29_10850 ENOG4105ENE Histidine kinase DQV29_10970 ENOG4105C4R Atp-dependent dna helicase DQV29_10980 ENOG4105KGF protein, YerC YecD DQV29_10995 ENOG4107DDB Cysteine protease able to DQV29_11020 ENOG4105DAP Nicotinate phosphoribosyltransferase DQV29_11025 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) DQV29_11030 ENOG4105CQC Prephenate dehydratase DQV29_11040 ENOG4105C8P )-transporter DQV29_11065 ENOG4105C26 Dehydrogenase DQV29_11120 ENOG4105CJ1 ABC, transporter DQV29_11135 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DQV29_11165 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DQV29_11215 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase DQV29_11265 ENOG4105DR5 peptidase DQV29_11315 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DQV29_11485 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DQV29_11540 ENOG4105CZN Potassium uptake protein DQV29_11600 ENOG4108WCX response regulator DQV29_11625 ENOG4105BZU Histidine kinase DQV29_11635 ENOG4105CUC YeeE YedE family protein DQV29_11645 ENOG4105C5H ABC transporter DQV29_11655 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DQV29_11665 ENOG410801F ribosomal-protein-alanine acetyltransferase DQV29_11670 ENOG41072GX Peptidase M22 Glycoprotease DQV29_11675 ENOG4105K8N protein family UPF0079, ATPase DQV29_11690 ENOG4105C7K acetolactate synthase DQV29_11710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DQV29_11790 ENOG4105WN5 stage II sporulation protein DQV29_11795 ENOG4107SGM protein serine threonine phosphatase DQV29_11815 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DQV29_11830 ENOG4105CKV Membrane DQV29_11840 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) DQV29_11845 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DQV29_11850 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DQV29_11860 ENOG4105C08 Histidine kinase DQV29_11865 ENOG4105EEX Two component transcriptional regulator (Winged helix family DQV29_11885 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DQV29_11910 ENOG4105VPX protein, conserved in bacteria DQV29_11915 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DQV29_11960 ENOG4105DWF phosphomethylpyrimidine kinase DQV29_11990 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DQV29_12050 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DQV29_12075 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DQV29_12080 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DQV29_12090 ENOG4107104 thymidine kinase DQV29_12105 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DQV29_12125 ENOG4105D2N Aldolase DQV29_12150 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DQV29_12180 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DQV29_12190 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DQV29_12195 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DQV29_12200 ENOG4108RMU ferritin dps family protein DQV29_12235 ENOG4105PGM cation diffusion facilitator family transporter DQV29_12270 ENOG4105DKW ABC transporter DQV29_12275 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DQV29_12280 ENOG4105CTS PTS system mannitol-specific DQV29_12285 ENOG4105ETD TRANSCRIPTIONal DQV29_12290 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein DQV29_12315 ENOG4105C8B TIGR00159 family DQV29_12320 ENOG4105CYW agmatinase DQV29_12375 ENOG4105D1F ATP-binding protein DQV29_12395 ENOG4108UT2 hemolysin iii DQV29_12400 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase DQV29_12405 ENOG4107K5X Membrane-bound metal-dependent hydrolase DQV29_12415 ENOG4105DWD nucleoside recognition domain protein DQV29_12420 ENOG4108U1V ABC transporter, permease DQV29_12425 ENOG4105DQ5 transport system permease protein DQV29_12430 ENOG4108HUF Transporter DQV29_12440 ENOG4106M28 alanine racemase domain protein DQV29_12450 ENOG4107SFI Major Facilitator superfamily DQV29_12475 ENOG4105C94 Transporter DQV29_12480 ENOG4105CIS alcohol dehydrogenase DQV29_12485 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DQV29_12500 ENOG4105CK1 PTS System DQV29_12505 ENOG4105VCP PTS System DQV29_12530 ENOG4105E98 transcriptional regulator DeoR family DQV29_12535 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DQV29_12555 ENOG4105VUF Transcriptional regulator DQV29_12565 ENOG4106AM8 polysaccharide lyase family 8 DQV29_12585 ENOG4107FQX Alpha-acetolactate decarboxylase DQV29_12600 ENOG4107RRE RNA-directed DNA polymerase DQV29_12665 ENOG4108JJB ABC transporter DQV29_12700 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DQV29_12705 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DQV29_12820 ENOG4105C7N Xanthine uracil vitamin C permease DQV29_12840 ENOG4105CSC Glucose uptake protein DQV29_12875 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) DQV29_12935 ENOG4108ZAF Molybdopterin DQV29_12940 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DQV29_12945 ENOG4105CVM Molybdenum cofactor synthesis domain protein DQV29_12955 ENOG4105EPU Molybdenum cofactor synthesis domain protein DQV29_12960 ENOG4105D06 uba thif-type nad fad binding protein DQV29_12965 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DQV29_12970 ENOG4105E0C molybdate abc transporter DQV29_12975 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DQV29_12990 ENOG4107ZYJ bioY protein DQV29_13005 ENOG4105FDT acyl-CoA dehydrogenase DQV29_13075 ENOG41068JE domain protein DQV29_13085 ENOG4105DFD Na H antiporter DQV29_13120 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis DQV29_13190 ENOG4107YBY Hydrolase DQV29_13195 ENOG4105C09 Bile acid DQV29_13205 ENOG4105CI1 PTS System DQV29_13210 ENOG4108Q3X Transcriptional regulator DQV29_13230 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DQV29_13235 ENOG4105CH2 amidohydrolase DQV29_13245 ENOG4105CGP Urocanate hydratase DQV29_13250 ENOG4105C5Q Transcriptional regulator DQV29_13270 ENOG4105E66 phosphoriboisomerase A DQV29_13275 ENOG4108RPX mosc domain containing protein DQV29_13295 ENOG4105RHA ABC transporter, permease DQV29_13300 ENOG4108IUX (ABC) transporter DQV29_13305 ENOG4105KAF membrAne DQV29_13325 ENOG4105D6U Sodium Glutamate Symporter DQV29_13335 ENOG4105D7N magnesium and cobalt transport protein CorA DQV29_13360 ENOG4105C0R drug resistance transporter emrb qaca subfamily DQV29_13365 ENOG4105CW7 secretion protein, HlyD family DQV29_13395 ENOG41062A4 Transcriptional regulator DQV29_13405 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DQV29_13435 ENOG4105DWT malate dehydrogenase (quinone) DQV29_13490 ENOG4105ECB domain protein DQV29_13520 ENOG410606W general stress protein DQV29_13560 ENOG4107TXC Transcriptional regulator DQV29_13590 ENOG4108IUE nitrate reductase beta subunit DQV29_13600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DQV29_13605 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DQV29_13610 ENOG4108IFG nitrite reductase, (NAD(P)H) DQV29_13620 ENOG4108XSB acetyltransferase, (GNAT) family DQV29_13625 ENOG4105TMB Formate nitrite transporter DQV29_13640 ENOG4105DSE periplasmic solute binding protein DQV29_13680 ENOG4105CDA abc transporter atp-binding protein DQV29_13685 ENOG4105DRP amino acid AbC transporter DQV29_13690 ENOG4105EAB amino acid AbC transporter DQV29_13750 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DQV29_13765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DQV29_13775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DQV29_13780 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DQV29_13795 ENOG4105BZ1 (ABC) transporter DQV29_13820 ENOG4105BZW Glycerate kinase DQV29_13830 ENOG4105C2C drug resistance transporter, Bcr CflA DQV29_13850 ENOG4105C85 amino acid DQV29_13855 ENOG4105EEQ Na H antiporter DQV29_13865 ENOG4105C0X amino acid DQV29_13875 ENOG4105ED2 Beta-lactamase DQV29_13890 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DQV29_13895 ENOG4105C57 major facilitator superfamily DQV29_13900 ENOG4105R40 Glycine betaine carnitine choline DQV29_13910 ENOG4105E90 ABC transporter DQV29_13930 ENOG4105CZ9 Domain of unknown function (DU1801) DQV29_13940 ENOG4107QTZ amino acid DQV29_13945 ENOG4105EBR Carboxylesterase DQV29_13950 ENOG4105F27 Major Facilitator DQV29_13955 ENOG4105C4B ABC transporter, permease DQV29_13960 ENOG41083J0 (ABC) transporter DQV29_13965 ENOG4105CN9 Peptidase m42 family protein DQV29_13985 ENOG4105PQ4 (LipO)protein DQV29_13990 ENOG4105CBC glutamate synthase DQV29_14045 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein DQV29_14050 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DQV29_14055 ENOG4105CFC Transporter DQV29_14060 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DQV29_14155 ENOG4105M6F mutator MutT protein DQV29_14160 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain DQV29_14235 ENOG4105CMG Carbohydrate kinase DQV29_14240 ENOG4105G3Z GntR family transcriptional regulator DQV29_14255 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DQV29_14265 ENOG4105DJB Major Facilitator Superfamily DQV29_14270 ENOG4107T5V SNARE associated Golgi DQV29_14290 ENOG4105CJ1 ABC, transporter DQV29_14310 ENOG4105FBA Phospholipase Carboxylesterase DQV29_14320 ENOG41090MY MarR family Transcriptional regulator DQV29_14330 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DQV29_14340 ENOG4105C5I Dehydrogenase DQV29_14345 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) DQV29_14350 ENOG4108Z15 abc transporter atp-binding protein DQV29_14355 ENOG4106KKU DQV29_14360 ENOG4108Z6X (sortase) family DQV29_14365 ENOG4108Z7F N-acetyltransferase DQV29_14380 ENOG4105EJQ L-serine dehydratase DQV29_14400 ENOG4108UZ3 Transporter DQV29_14430 ENOG41067MG lrgb family DQV29_14440 ENOG4105CMU LysR family (Transcriptional regulator DQV29_14450 ENOG41068JE domain protein DQV29_14460 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DQV29_14465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DQV29_14470 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DQV29_14480 ENOG4105CE1 Ferrous iron transport protein b DQV29_14490 ENOG4105EYF MMPL domain protein DQV29_14545 ENOG4105FE1 phytoene synthase DQV29_14550 ENOG41076QQ Glycosyl transferase, family 2 DQV29_14555 ENOG4105EWK phytoene DQV29_14565 ENOG41068JE domain protein DQV29_14570 ENOG4105EXC Acyl-transferase DQV29_14630 ENOG4105CHR reductase DQV29_14655 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase DQV29_14680 ENOG4105FGM Fructosamine kinase DQV29_14685 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) DQV29_14740 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DQV29_14745 ENOG4107FQX Alpha-acetolactate decarboxylase DQV29_14760 ENOG4105CUB amino acid DQV29_14765 ENOG4108JPW Aminotransferase DQV29_14780 ENOG4105DWT malate dehydrogenase (quinone) DQV29_14790 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DQV29_14810 ENOG4105C26 Dehydrogenase DQV29_14820 ENOG4105TRT Transcriptional regulator DQV29_14825 ENOG4105C94 Transporter DQV29_14840 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) DQV29_14845 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DQV29_14850 ENOG4105D4T Citrate transporter DQV29_14860 ENOG4108Z73 Siroheme synthase DQV29_14865 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DQV29_14920 ENOG4105G6Z alkaline phosphatase DQV29_14930 ENOG4108U05 Transcriptional regulator DQV29_14940 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps DQV29_14950 ENOG4105C5B carbamate kinase DQV29_14960 ENOG4105DBV ornithine carbamoyltransferase DQV29_15000 ENOG4105DM4 PTS System DQV29_15005 ENOG4105DG6 mannose-6-phosphate isomerase DQV29_15015 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase DQV29_15020 ENOG4105WQI isochorismatase DQV29_15045 ENOG4106E62 Accessory Sec system protein Asp3 DQV29_15050 ENOG41089G2 accessory Sec system protein Asp2 DQV29_15055 ENOG4108XJK accessory Sec system protein Asp1 DQV29_15070 ENOG4105EW6 flavin reductase domain protein, FMN-binding DQV29_15090 ENOG4107XC4 flavin reductase domain protein, FMN-binding DQV29_15095 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DQV29_15115 ENOG4105HTX biosynthesis protein DQV29_15120 ENOG4108IG5 Transcriptional regulator DQV29_15125 ENOG4107QJZ Glycosyl transferase, family 2 DQV29_15135 ENOG4107UVV polysaccharide deacetylase DQV29_15150 ENOG4105J1V Triacylglycerol lipase DQV29_15160 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DQV29_15175 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DQV29_15185 ENOG4105CIH Imidazole acetol-phosphate transaminase DQV29_15190 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DQV29_15270 ENOG4107QPK )-transporter DQV29_15275 ENOG4105FR1 rard protein DQV29_15285 ENOG4105D9G High-affinity DQV29_15300 ENOG4105C19 ABC transporter DQV29_15335 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) DQV29_15375 ENOG4108UUM single-stranded DNA-binding protein DQV29_15410 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DQV29_15515 ENOG4108BUD transposase DQV29_15520 ENOG4108S3A nucleotidyltransferase DQV29_15530 ENOG4108BUD transposase DQV29_15550 ENOG4108BUD transposase DQV29_15590 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase DQV29_15600 ENOG4105C9U ATP-dependent DNA helicase RecQ DQV29_15695 ENOG4108U7W acetyltransferase DQV29_15710 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)