locus-tag class description E3S63_00020 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E3S63_00070 ENOG4105DR5 peptidase E3S63_00120 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S63_00185 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family E3S63_00200 ENOG4105CJ1 ABC, transporter E3S63_00255 ENOG4105C26 Dehydrogenase E3S63_00280 ENOG4105C8P )-transporter E3S63_00290 ENOG4105CQC Prephenate dehydratase E3S63_00295 ENOG4107QN4 Catalyzes the production of nitric oxide (By similarity) E3S63_00300 ENOG4105DAP Nicotinate phosphoribosyltransferase E3S63_00325 ENOG4107DDB Cysteine protease able to E3S63_00335 ENOG4105KGF protein, YerC YecD E3S63_00345 ENOG4105C4R Atp-dependent dna helicase E3S63_00440 ENOG4108V3A UPF0421 protein E3S63_00445 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E3S63_00460 ENOG4105ENE Histidine kinase E3S63_00470 ENOG4107U9T Pfam:Ribonuclease_BN E3S63_00495 ENOG4108S4H thioesterase Superfamily protein E3S63_00510 ENOG4108Z0Z intracellular protease Pfpi family E3S63_00530 ENOG4105EY8 ABC transporter E3S63_00540 ENOG41067AE Membrane-bound metal-dependent hydrolase E3S63_00565 ENOG4107NBY Membrane E3S63_00575 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E3S63_00580 ENOG4108M3J Dehydrogenase E3S63_00755 ENOG4105E5Q amino acid AbC transporter E3S63_00760 ENOG4105CDA abc transporter atp-binding protein E3S63_00765 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E3S63_00790 ENOG4105C9Q fumarate hydratase class II E3S63_00795 ENOG4108YBP pseudouridine synthase E3S63_00800 ENOG4105BZU Histidine kinase E3S63_00805 ENOG4105WH1 Two component transcriptional regulator luxr family E3S63_00830 ENOG4107VRP DNA repair exonuclease E3S63_00860 ENOG4105K59 histidine triad (HIT) protein E3S63_00890 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) E3S63_00895 ENOG4105C1Q protoporphyrinogen oxidase E3S63_01140 ENOG4105E09 nadh pyrophosphatase E3S63_01165 ENOG4105CV8 reductase E3S63_01175 ENOG4105WMR Protein CrcB homolog E3S63_01180 ENOG4105WMR Protein CrcB homolog E3S63_01190 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E3S63_01220 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S63_01225 ENOG4107R3E Citrate transporter E3S63_01240 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E3S63_01245 ENOG4108R6K riboflavin synthase, subunit alpha E3S63_01270 ENOG4105E8V Alpha Beta Hydrolase Fold protein E3S63_01285 ENOG4105N5T Radical SAM Protein E3S63_01290 ENOG410605W Major Facilitator E3S63_01310 ENOG4105CBX hi0933 family E3S63_01335 ENOG4105F0I Aminotransferase E3S63_01340 ENOG4108V15 phosphotransferase enzyme family E3S63_01350 ENOG4105C8F Beta-lactamase domain protein E3S63_01375 ENOG4108VDD TRNA binding domain protein E3S63_01405 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase E3S63_01415 ENOG4105ETE Transcriptional regulator (LacI family E3S63_01420 ENOG4105DGU Histone deacetylase E3S63_01425 ENOG4105F1V Acetoin utilization protein E3S63_01465 ENOG4105C0H protease E3S63_01470 ENOG4105F6E Acyl-transferase E3S63_01490 ENOG4108JQ1 Dehydrogenase E3S63_01495 ENOG4105C5R Aminotransferase E3S63_01500 ENOG4108X3M OsmC Ohr family protein E3S63_01505 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E3S63_01545 ENOG4105EJ9 Membrane E3S63_01550 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) E3S63_01600 ENOG4105SFS phosphoesterase RecJ domain protein E3S63_01605 ENOG4105C0B DNA polymerase III (alpha subunit) E3S63_01610 ENOG4105C6K Malic enzyme E3S63_01635 ENOG4105C85 amino acid E3S63_01640 ENOG4105BZN citrate synthase E3S63_01645 ENOG4108HMX isocitrate dehydrogenase (NADP) E3S63_01650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E3S63_01655 ENOG4105BZU Histidine kinase E3S63_01665 ENOG4105C2M dna polymerase I E3S63_01675 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E3S63_01680 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E3S63_01710 ENOG4108IQI permease E3S63_01730 ENOG4105U6W MutT NUDIX family protein E3S63_01780 ENOG4105D52 delta-aminolevulinic acid dehydratase E3S63_01800 ENOG4108R3E Dna-3-methyladenine glycosylase i E3S63_01810 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E3S63_01815 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) E3S63_01825 ENOG4108FPN Integrase E3S63_01830 ENOG4108KU9 integrase family E3S63_01835 ENOG4105ZX1 Transposase C E3S63_01840 ENOG4106JUT Streptomycin 3''-adenylyltransferase E3S63_01845 ENOG41071EZ rRNA adenine N-6-methyltransferase E3S63_01855 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) E3S63_01900 ENOG4105X36 (ribosomal) protein E3S63_01940 ENOG4105VIE preprotein translocase, subunit YajC E3S63_01945 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E3S63_01950 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E3S63_01970 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase E3S63_01995 ENOG4105CUZ uba thif-type nad fad binding protein E3S63_02000 ENOG4105D1H recombination factor protein RarA E3S63_02010 ENOG41061M1 UPF0337 protein E3S63_02020 ENOG4105DEN Luciferase family E3S63_02025 ENOG4105C3J Cysteine desulfurase E3S63_02040 ENOG4105C7H Helicase, RecD TraA family E3S63_02070 ENOG4105XYU peptidase (U32 family) E3S63_02075 ENOG4105CFP Peptidase U32 E3S63_02090 ENOG4105P4J Allophanate hydrolase, subunit 1 E3S63_02100 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E3S63_02105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3S63_02115 ENOG4105C5A transporter E3S63_02140 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase E3S63_02145 ENOG4105CQW ribosome biogenesis GTPase YqeH E3S63_02155 ENOG410812S Rna-binding protein E3S63_02165 ENOG4108WF2 Metal Dependent Phosphohydrolase E3S63_02170 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) E3S63_02175 ENOG4105DXX methyltransferase E3S63_02180 ENOG4105BZM domain protein E3S63_02185 ENOG4108UK2 deaminase E3S63_02190 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 E3S63_02195 ENOG4105TQK DNA polymerase iii, delta' subunit E3S63_02210 ENOG4105CSA Coproporphyrinogen iii oxidase E3S63_02240 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E3S63_02245 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) E3S63_02255 ENOG4105F7J membrane-bound serine protease E3S63_02270 ENOG4105C9A Phoh family E3S63_02285 ENOG4105KG3 cytidine deaminase E3S63_02315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E3S63_02320 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E3S63_02330 ENOG4105EGD dinuclear metal center protein, YbgI family E3S63_02335 ENOG4105C1J atp-dependent rna helicase E3S63_02345 ENOG4105FDK ABC transporter E3S63_02350 ENOG4105FAV ABC, transporter E3S63_02355 ENOG4105N80 Ferric uptake regulator, Fur family E3S63_02360 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E3S63_02365 ENOG4107RF6 penicillin-binding protein E3S63_02375 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E3S63_02400 ENOG4105C5X domain protein E3S63_02410 ENOG4105D7Q type ii secretion system E3S63_02415 ENOG4106855 Competence protein E3S63_02460 ENOG4105WZW rhodanese family E3S63_02465 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) E3S63_02480 ENOG4105DC7 peptidase M24 E3S63_02495 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E3S63_02500 ENOG4108ZSR alkaline shock protein E3S63_02530 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E3S63_02545 ENOG4105CPP Dehydrogenase, E1 component E3S63_02550 ENOG4105C7S Dehydrogenase E3S63_02560 ENOG4108QEG Membrane E3S63_02570 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) E3S63_02610 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase E3S63_02625 ENOG4105PDP Short chain dehydrogenase E3S63_02635 ENOG4105CPC Aldo Keto reductase E3S63_02640 ENOG4108YZ4 nudix hydrolase E3S63_02645 ENOG4105I3K Ferric uptake regulator, Fur family E3S63_02650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E3S63_02670 ENOG4105FE9 pseudouridine synthase E3S63_02675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3S63_02730 ENOG4105C9U ATP-dependent DNA helicase RecQ E3S63_02745 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase E3S63_02750 ENOG4105HDK L-asparaginase E3S63_02785 ENOG4105K70 DNA-binding protein E3S63_02800 ENOG4105EAH synthase E3S63_02850 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase E3S63_02855 ENOG4105CPK Glycosyl transferase (Group 1 E3S63_02885 ENOG4105CSM endonuclease III E3S63_02895 ENOG4105BZ4 penicillin-binding protein E3S63_02930 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) E3S63_02945 ENOG410890F Dynamin family E3S63_02955 ENOG4105DCF alanine dehydrogenase E3S63_02965 ENOG4107R7I amino acid E3S63_03015 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) E3S63_03020 ENOG4108RCR degv family E3S63_03025 ENOG4108FKN Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S63_03035 ENOG4105C5Y PTS System E3S63_03060 ENOG410841Q phosphoesterase PA-phosphatase related protein E3S63_03075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E3S63_03105 ENOG4105GMT ATPase associated with various cellular activities aaa_5 E3S63_03110 ENOG4107T89 von Willebrand factor, type A E3S63_03150 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E3S63_03155 ENOG4108XFP Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E3S63_03180 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) E3S63_03185 ENOG4105CFH Aspartokinase E3S63_03190 ENOG4105C5H ABC transporter E3S63_03210 ENOG4105C8U phosphate abc transporter E3S63_03215 ENOG4105E2Z phosphate ABC transporter (Permease E3S63_03220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E3S63_03225 ENOG4108UTW Plays a role in the regulation of phosphate uptake E3S63_03230 ENOG4105DPN Oligoendopeptidase f E3S63_03280 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) E3S63_03315 ENOG4105DDQ anthranilate synthase E3S63_03320 ENOG4105CRQ synthase (Component I) E3S63_03325 ENOG4105DER m42 family E3S63_03335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E3S63_03345 ENOG4108RCF TRANSCRIPTIONal E3S63_03350 ENOG4108FKN Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S63_03380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S63_03385 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S63_03405 ENOG4108I0Z Aconitate hydratase E3S63_03410 ENOG4105C94 Transporter E3S63_03445 ENOG4105CV1 Transketolase (EC 2.2.1.1) E3S63_03450 ENOG4105VPS UPF0291 protein E3S63_03465 ENOG4105K4I Scp-like extracellular E3S63_03495 ENOG4108IQI permease E3S63_03520 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) E3S63_03525 ENOG4105D6E homoserine dehydrogenase E3S63_03530 ENOG4105CFH Aspartokinase E3S63_03555 ENOG4108S01 response regulator E3S63_03575 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) E3S63_03645 ENOG4105C5F glutamine synthetase E3S63_03650 ENOG4105KV4 Transcriptional regulator E3S63_03655 ENOG4105CXI aluminum resistance protein E3S63_03660 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E3S63_03665 ENOG4108V06 Glutathione peroxidase E3S63_03670 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E3S63_03695 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) E3S63_03700 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator E3S63_03735 ENOG4105DQU oxidoreductase, subunit beta E3S63_03740 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein E3S63_03745 ENOG4105D48 metallophosphoesterase E3S63_03765 ENOG4105CEV competence damage-inducible protein E3S63_03770 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E3S63_03785 ENOG4108RKS Short-chain dehydrogenase reductase Sdr E3S63_03800 ENOG4105FDP GntR family transcriptional regulator E3S63_03805 ENOG4105CNU cell division protein FtsK E3S63_03825 ENOG4105DTN riboflavin biosynthesis protein ribF E3S63_03850 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination E3S63_03855 ENOG4105CHV Transcription elongation factor NusA E3S63_03875 ENOG4105DZP Membrane-associated zinc metalloprotease E3S63_03880 ENOG4105KNE Phosphatidate cytidylyltransferase E3S63_03885 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E3S63_03955 ENOG4108RMH femAB family E3S63_03965 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E3S63_03980 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) E3S63_04020 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E3S63_04025 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E3S63_04040 ENOG4105CHR reductase E3S63_04060 ENOG4105CB5 ATP-dependent DNA helicase recG E3S63_04070 ENOG4108ZAA Alkaline-shock protein E3S63_04085 ENOG4105DJV ribulose-phosphate 3-epimerase E3S63_04090 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E3S63_04100 ENOG4108ZF3 Phosphatase E3S63_04110 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E3S63_04120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E3S63_04125 ENOG4105YB8 TM2 domain containing protein E3S63_04135 ENOG4105C25 Primosomal protein n' E3S63_04140 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E3S63_04150 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E3S63_04170 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) E3S63_04185 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E3S63_04190 ENOG4105CD3 dihydroorotase E3S63_04210 ENOG4105C34 Pseudouridine synthase E3S63_04225 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E3S63_04240 ENOG4105DBK s4 domain protein E3S63_04245 ENOG41067XK integral membrane protein E3S63_04255 ENOG4105DFA alanine racemase domain protein E3S63_04265 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E3S63_04270 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E3S63_04275 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) E3S63_04290 ENOG4105CJN penicillin-binding protein E3S63_04295 ENOG41068DC Essential cell division protein (By similarity) E3S63_04355 ENOG4105CSX c4-dicarboxylate anaerobic carrier E3S63_04365 ENOG4105DBV ornithine carbamoyltransferase E3S63_04395 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity E3S63_04455 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) E3S63_04465 ENOG4105E33 succinate dehydrogenase E3S63_04475 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit E3S63_04490 ENOG4105K63 Thioredoxin E3S63_04500 ENOG4105DCG PHP domain protein E3S63_04520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E3S63_04530 ENOG4108RWN rrna methyltransferase E3S63_04545 ENOG4105KFN sortase, SrtB family E3S63_04600 ENOG4106H78 methyltransferase E3S63_04650 ENOG4105CNI cell division protein FtsW E3S63_04670 ENOG4105CI3 gtp-binding protein typa E3S63_04680 ENOG4105ECY inositol monophosphatase E3S63_04705 ENOG4107RUE extracellular solute-binding protein family 1 E3S63_04710 ENOG4105D38 putrescine abc transporter E3S63_04715 ENOG4105F38 ABC transporter, permease E3S63_04735 ENOG4107QN2 dihydrolipoyl dehydrogenase E3S63_04740 ENOG4105C7S Dehydrogenase E3S63_04745 ENOG4105CPP Dehydrogenase, E1 component E3S63_04750 ENOG4107RUY (E1 component), alpha subunit E3S63_04760 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E3S63_04780 ENOG4107ZYR domain protein E3S63_04795 ENOG41067VN Glutaredoxin E3S63_04805 ENOG4105KRI phosphocarrier protein (HPr E3S63_04815 ENOG4105DR4 Methyltransferase E3S63_04835 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein E3S63_04840 ENOG4108JJB ABC transporter E3S63_04845 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) E3S63_04850 ENOG4105C12 Phosphoribosylglycinamide synthetase E3S63_04860 ENOG4108V3E phosphoribosylglycinamide formyltransferase E3S63_04870 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E3S63_04880 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I E3S63_04885 ENOG4105VR9 phosphoribosylformylglycinamidine synthase E3S63_04900 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E3S63_04940 ENOG4105FQP Beta-lactamase E3S63_04945 ENOG4108KGH TRANSCRIPTIONal E3S63_04955 ENOG4108HPG -acetyltransferase E3S63_04975 ENOG4108TGC Acyltransferase E3S63_04980 ENOG4105CHM Aminotransferase E3S63_05005 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) E3S63_05015 ENOG4105E4F Isochorismate synthase E3S63_05025 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase E3S63_05030 ENOG41080E2 ribosomal-protein-alanine acetyltransferase E3S63_05035 ENOG4105YB8 TM2 domain containing protein E3S63_05045 ENOG4108HUF Transporter E3S63_05065 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E3S63_05115 ENOG4105XVF Competence transcription factor E3S63_05130 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic E3S63_05145 ENOG4107TS3 membrane protein, TerC E3S63_05185 ENOG4105BZG amino acid carrier protein E3S63_05190 ENOG4105C02 permease E3S63_05205 ENOG4105CJW magnesium transporter E3S63_05210 ENOG4105EMS pseudouridine synthase E3S63_05235 ENOG4108Z18 K06886 hemoglobin E3S63_05245 ENOG4105DPN Oligoendopeptidase f E3S63_05260 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) E3S63_05265 ENOG4105C31 Tryptophanyl-tRNA synthetase E3S63_05270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S63_05280 ENOG4108JQ7 (ABC) transporter E3S63_05290 ENOG4105DEF Extracellular solute-binding protein, family 5 E3S63_05300 ENOG4108JQ7 (ABC) transporter E3S63_05310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S63_05315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S63_05345 ENOG4105KIS phospholipid-binding protein E3S63_05385 ENOG4108KP7 hydrolase E3S63_05415 ENOG4105C3F Signal peptidase i E3S63_05445 ENOG4107VXM glycerophosphoryl diester phosphodiesterase E3S63_05450 ENOG4105D82 Glutamate dehydrogenase E3S63_05455 ENOG4105C8Y Acetylornithine aminotransferase E3S63_05460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E3S63_05465 ENOG41060GV RNA binding s1 domain protein E3S63_05520 ENOG4105KA0 thioesterase Superfamily protein E3S63_05530 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) E3S63_05540 ENOG4108YX9 iron--sulfur cluster insertion protein erpA E3S63_05560 ENOG41083MR nifu domain-containing protein E3S63_05565 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD E3S63_05575 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein E3S63_05620 ENOG4105MMD transcriptional regulator E3S63_05640 ENOG4105I3N Conserved Protein E3S63_05690 ENOG4105ZMJ n-acetylmuramoyl-l-alanine amidase E3S63_05710 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S63_05865 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) E3S63_05920 ENOG4106CVF DNA replication protein E3S63_05940 ENOG4108UUM single-stranded DNA-binding protein E3S63_06030 ENOG4108UNV SUF system FeS assembly protein, NifU family E3S63_06035 ENOG4105C9B Cysteine desulfurase E3S63_06040 ENOG4105JRK feS assembly protein SufD E3S63_06045 ENOG4105C3K feS assembly ATPase SufC E3S63_06060 ENOG4105D01 (LipO)protein E3S63_06065 ENOG4108UMI ABC transporter, permease E3S63_06085 ENOG4108XI2 Domain of unknown function (DUF1963) E3S63_06100 ENOG41080E8 Transcriptional regulator, Spx MgsR family E3S63_06105 ENOG4105SZ6 Thioredoxin E3S63_06130 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E3S63_06135 ENOG4105CVJ phosphoglycerate mutase E3S63_06175 ENOG4105VEQ Cold shock protein E3S63_06200 ENOG4106HV3 Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps E3S63_06200 ENOG4106HV3 Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps E3S63_06245 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E3S63_06255 ENOG4105XZU Preprotein translocase, subunit SecG E3S63_06270 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E3S63_06285 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E3S63_06315 ENOG4105CHW UPF0052 protein E3S63_06325 ENOG4105C3M thioredoxin reductase E3S63_06335 ENOG4108S4C acetyltransferase E3S63_06350 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E3S63_06355 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E3S63_06370 ENOG41068JE domain protein E3S63_06400 ENOG41081UC Inherit from COG: Competence protein E3S63_06410 ENOG4105EPR degv family E3S63_06415 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein E3S63_06420 ENOG4105ESV Glycosyl transferase, family 4 E3S63_06485 ENOG4108IPW abc transporter atp-binding protein E3S63_06490 ENOG4105CM4 permease protein E3S63_06495 ENOG4105DHS permease protein E3S63_06505 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3S63_06510 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E3S63_06530 ENOG4105DUX Transporter E3S63_06545 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C E3S63_06555 ENOG4105E90 ABC transporter E3S63_06560 ENOG4108IJ8 ABC transporter E3S63_06565 ENOG4105C9U ATP-dependent DNA helicase RecQ E3S63_06570 ENOG4105C5H ABC transporter E3S63_06600 ENOG4105CRQ synthase (Component I) E3S63_06605 ENOG4105DDQ anthranilate synthase E3S63_06615 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase E3S63_06620 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E3S63_06650 ENOG4105CKK Glycosyl transferase, family 2 E3S63_06660 ENOG4105C37 (CBS) domain E3S63_06665 ENOG4105CE4 GlcNAc 6-P deacetylase E3S63_06670 ENOG4105DM4 PTS System E3S63_06675 ENOG4105DE4 1-phosphofructokinase E3S63_06680 ENOG4105E98 transcriptional regulator DeoR family E3S63_06685 ENOG4108Z66 YbaK ebsC protein E3S63_06695 ENOG4105DP8 Major facilitator superfamily MFS_1 E3S63_06715 ENOG4105CVP deoxyribo-dipyrimidine photolyase E3S63_06720 ENOG4107QPK )-transporter E3S63_06730 ENOG4107QM2 Aldo Keto reductase E3S63_06735 ENOG4105CKI cobalamin synthesis protein E3S63_06740 ENOG4105K56 Transcriptional regulator E3S63_06745 ENOG4108JJ8 (ABC) transporter E3S63_06750 ENOG4108JJ9 ABC, transporter E3S63_06770 ENOG4108URH decarboxylase E3S63_06775 ENOG4108YYQ gCN5-related N-acetyltransferase E3S63_06800 ENOG4105SXS Protein of unknown function (DUF456) E3S63_06805 ENOG4105S8Q sugar efflux transporter E3S63_06840 ENOG4105ID8 Transcriptional regulator, ARAC family E3S63_06850 ENOG4105VRS hydrolase family 18 E3S63_06855 ENOG4105CJ3 phosphate transporter E3S63_06860 ENOG4107GRR phosphate transport regulator E3S63_06870 ENOG4105C19 ABC transporter E3S63_06905 ENOG4108K88 Membrane E3S63_06915 ENOG4105VDH Dihydroxyacetone kinase E3S63_06925 ENOG4105CMT Dihydroxyacetone kinase E3S63_06930 ENOG4105EHG Permease protein E3S63_06935 ENOG4105DQ5 transport system permease protein E3S63_06940 ENOG4105E0A ABC, transporter E3S63_06945 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) E3S63_06960 ENOG4105BZ1 (ABC) transporter E3S63_06970 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase E3S63_06990 ENOG4105EY8 ABC transporter E3S63_06995 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family E3S63_07005 ENOG4107R5H iron (metal) dependent repressor, dtxr family E3S63_07010 ENOG4105DIK (ABC) transporter E3S63_07015 ENOG4105CC5 ABC transporter E3S63_07020 ENOG4105DSE periplasmic solute binding protein E3S63_07030 ENOG4105EEQ Na H antiporter E3S63_07070 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off E3S63_07110 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) E3S63_07125 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) E3S63_07155 ENOG4108XFG YwhD family E3S63_07160 ENOG4105DCI Phosphohydrolase E3S63_07170 ENOG4108WS4 fmn reductase E3S63_07175 ENOG4105CPC Aldo Keto reductase E3S63_07210 ENOG4107QN2 dihydrolipoyl dehydrogenase E3S63_07230 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) E3S63_07235 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) E3S63_07240 ENOG4108IJ2 phosphate acetyltransferase E3S63_07280 ENOG4105DWF phosphomethylpyrimidine kinase E3S63_07305 ENOG4107F3J Amp-dependent synthetase and ligase E3S63_07310 ENOG4105CSH Transporter E3S63_07325 ENOG4108VA3 3-hexulose-6-phosphate synthase E3S63_07340 ENOG4107YEI lmbE family E3S63_07380 ENOG410667J hydrolase E3S63_07385 ENOG4108Z6B deaminase E3S63_07395 ENOG4105ZMH deoxynucleoside kinase E3S63_07400 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase E3S63_07405 ENOG4105CM2 brancheD-chain amino acid aminotransferase E3S63_07460 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) E3S63_07470 ENOG4107Y49 methyltransferase E3S63_07500 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E3S63_07530 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) E3S63_07550 ENOG4105CTP PilT protein domain protein E3S63_07555 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E3S63_07570 ENOG4108Z0C Uvrb UvrC protein E3S63_07580 ENOG4105D9N nucleoside E3S63_07595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E3S63_07675 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E3S63_07680 ENOG4105KRF dihydroneopterin aldolase E3S63_07685 ENOG4105EEI dihydropteroate synthase E3S63_07690 ENOG4105C6T cysteine synthase E3S63_07700 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E3S63_07705 ENOG4108UGV hypoxanthine phosphoribosyltransferase E3S63_07715 ENOG41060GV RNA binding s1 domain protein E3S63_07725 ENOG41082I2 s4 domain protein E3S63_07730 ENOG4108IY2 MazG family E3S63_07755 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E3S63_07775 ENOG4105KME endoribonuclease L-psp E3S63_07780 ENOG4105DFT pur operon repressor E3S63_07790 ENOG4105W42 Veg protein E3S63_07800 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) E3S63_07805 ENOG4105F8V Hydrolase, tatD family E3S63_07810 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E3S63_07815 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E3S63_07825 ENOG41060K3 Methyltransferase E3S63_07835 ENOG4105MA4 psp1 domain protein E3S63_07840 ENOG4105FA2 dna polymerase iii E3S63_07845 ENOG4105X0R protein from nitrogen regulatory protein P-II E3S63_07855 ENOG4105CXN decarboxylase E3S63_07890 ENOG4105C6E dna polymerase iii E3S63_07910 ENOG4107414 GntR family transcriptional regulator E3S63_07915 ENOG4105CG3 alpha amylase, catalytic region E3S63_07920 ENOG4105C5Y PTS System E3S63_07930 ENOG4105BZ8 glutamate synthase E3S63_07935 ENOG4105CBC glutamate synthase E3S63_07940 ENOG4105C5Q Transcriptional regulator E3S63_07970 ENOG41068JE domain protein E3S63_07975 ENOG4105D01 (LipO)protein E3S63_07980 ENOG4108UMI ABC transporter, permease E3S63_07990 ENOG4105C28 cystathionine E3S63_08000 ENOG4105C8J )-transporter E3S63_08020 ENOG4105GPN Uncharacterized conserved protein (DUF2294) E3S63_08030 ENOG4108TWJ NADH dehydrogenase subunit 5 E3S63_08055 ENOG4105CKI cobalamin synthesis protein E3S63_08215 ENOG4105KA3 membrAne E3S63_08245 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E3S63_08250 ENOG4105C2W permease E3S63_08280 ENOG4107R6U sodium dicarboxylate symporter E3S63_08290 ENOG4105D3R alkyl hydroperoxide reductase E3S63_08295 ENOG4108JU3 Alkyl hydroperoxide reductase E3S63_08365 ENOG4108UUM single-stranded DNA-binding protein E3S63_08380 ENOG4105C3G gtp-binding protein E3S63_08385 ENOG4105VDK protein, conserved in bacteria E3S63_08390 ENOG4105D8X mechanosensitive ion channel E3S63_08395 ENOG4105FA0 parb-like partition protein E3S63_08400 ENOG4105C28 cystathionine E3S63_08405 ENOG4105C28 cystathionine E3S63_08440 ENOG4105CJ1 ABC, transporter E3S63_08450 ENOG4105VZ8 Transcriptional regulator E3S63_08460 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) E3S63_08465 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) E3S63_08470 ENOG4107SJW iron permease, FTR1 E3S63_08480 ENOG410650H (LipO)protein E3S63_08495 ENOG4107V0Z fmn reductase E3S63_08510 ENOG4105CXY transporter E3S63_08530 ENOG4105CID antiterminator E3S63_08535 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia E3S63_08545 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC E3S63_08550 ENOG4105CMR udp-glucose 4-epimerase E3S63_08565 ENOG4108UVJ appr-1-p processing domain protein E3S63_08575 ENOG4105DEN Luciferase family E3S63_08600 ENOG4105DWD nucleoside recognition domain protein E3S63_08610 ENOG4106KNT transcriptional regulator E3S63_08625 ENOG4107RJ1 sodium solute E3S63_08630 ENOG4105D9N nucleoside E3S63_08660 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) E3S63_08665 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family E3S63_08760 ENOG4105EC2 ftsk spoIIIe E3S63_08790 ENOG4105VRS hydrolase family 18 E3S63_08810 ENOG4105DA5 (ABC) transporter E3S63_08845 ENOG4105EV1 Ribose uptake protein RbsU E3S63_08865 ENOG4105DVA methyltransferase E3S63_08870 ENOG4105CS2 ec 3.2.1.21 E3S63_08875 ENOG4105CI1 PTS System E3S63_08895 ENOG4105DY9 regulatoR E3S63_08900 ENOG4108HRK Histidine kinase E3S63_08915 ENOG4107RZX Teichoic acid biosynthesis protein E3S63_08920 ENOG4105EJJ Dehydrogenase E3S63_08930 ENOG4107SJB teichoic acid biosynthesis E3S63_08935 ENOG4107RZX Teichoic acid biosynthesis protein E3S63_08940 ENOG4105EJJ Dehydrogenase E3S63_08945 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) E3S63_08950 ENOG4105CPQ Dehydrogenase E3S63_08960 ENOG4105CPQ Dehydrogenase E3S63_08965 ENOG4105DT3 PTS system, galactitol-specific IIc component E3S63_08970 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) E3S63_08990 ENOG4105DU0 nucleoside hydrolase E3S63_08995 ENOG4105CI1 PTS System E3S63_09020 ENOG4105K78 MarR family Transcriptional regulator E3S63_09025 ENOG4107RRN ABC transporter substrate-binding protein E3S63_09035 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) E3S63_09040 ENOG4105CEY Amp-dependent synthetase and ligase E3S63_09045 ENOG4105C1G acyl-Coa dehydrogenase E3S63_09050 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E3S63_09055 ENOG4105CHU acetyl-coa acetyltransferase E3S63_09105 ENOG4105CXY transporter E3S63_09110 ENOG4108WWS isoprenylcysteine carboxyl methyltransferase E3S63_09120 ENOG4105CK5 oxidoreductase E3S63_09130 ENOG4105EG2 ABC transporter, permease E3S63_09165 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E3S63_09175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E3S63_09180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component E3S63_09195 ENOG4105DA5 (ABC) transporter E3S63_09220 ENOG4105C19 ABC transporter E3S63_09245 ENOG4105QEK Transcriptional regulator E3S63_09275 ENOG4107RA9 decarboxylase E3S63_09280 ENOG4105D3W isochorismatase E3S63_09285 ENOG4105CWM branched-chain amino acid transport system II carrier protein E3S63_09290 ENOG4105C8Y Acetylornithine aminotransferase E3S63_09300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E3S63_09335 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) E3S63_09340 ENOG4105C1G acyl-Coa dehydrogenase E3S63_09370 ENOG4105PGM cation diffusion facilitator family transporter E3S63_09380 ENOG4105WD1 Membrane E3S63_09390 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S63_09405 ENOG4105D3Q Sugar transferase E3S63_09435 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S63_09445 ENOG4105C5E polysaccharide biosynthesis protein E3S63_09470 ENOG4105C0A alcohol dehydrogenase E3S63_09485 ENOG4105CGH 5'-nucleotidase E3S63_09520 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E3S63_09525 ENOG4108J8C transporter major facilitator family protein E3S63_09530 ENOG4105D3A purine nucleoside phosphorylase DeoD-type E3S63_09545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E3S63_09560 ENOG4105CPK Glycosyl transferase (Group 1 E3S63_09570 ENOG4108IAJ Nad-dependent epimerase dehydratase E3S63_09580 ENOG4105CHR reductase E3S63_09590 ENOG41067FT ParB-like nuclease domain E3S63_09595 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E3S63_09605 ENOG4105DUU IucA IucC family protein E3S63_09610 ENOG4105DBM Siderophore biosynthesis protein E3S63_09615 ENOG4105C6X Major Facilitator E3S63_09620 ENOG4105DJU Siderophore biosynthesis protein E3S63_09625 ENOG4105CIF Ornithine Cyclodeaminase E3S63_09635 ENOG4108MES Periplasmic binding protein E3S63_09640 ENOG4105DQ5 transport system permease protein E3S63_09645 ENOG4108IHU transport system permease protein E3S63_09675 ENOG4107Y9U Membrane E3S63_09680 ENOG4105CCI Myosin-Cross-Reactive Antigen E3S63_09690 ENOG4105C57 major facilitator superfamily E3S63_09730 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C E3S63_09760 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E3S63_09775 ENOG4105C5X domain protein E3S63_09780 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase E3S63_09785 ENOG4105XTG Pfam:DUF156 E3S63_09790 ENOG41087NI Sulfite exporter TauE/SafE E3S63_09840 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) E3S63_09845 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E3S63_09850 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E3S63_09920 ENOG410826E Dna repair protein radc E3S63_09925 ENOG4108FPN Integrase E3S63_09930 ENOG4108KU9 integrase family E3S63_09935 ENOG4105ZX1 Transposase C E3S63_09940 ENOG4106JUT Streptomycin 3''-adenylyltransferase E3S63_09945 ENOG41071EZ rRNA adenine N-6-methyltransferase E3S63_09955 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) E3S63_09965 ENOG41087NI Sulfite exporter TauE/SafE E3S63_09970 ENOG4105XTG Pfam:DUF156 E3S63_09975 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase E3S63_09980 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E3S63_10005 ENOG4105CCN Peptidase M56 E3S63_10010 ENOG4107RVG penicillin-binding protein E3S63_10015 ENOG4108ZMQ domain protein E3S63_10020 ENOG4108QXE glycerophosphoryl diester phosphodiesterase E3S63_10025 ENOG4108BUD transposase E3S63_10030 ENOG4108S3A nucleotidyltransferase E3S63_10040 ENOG4106PHI plasmid recombination enzyme E3S63_10045 ENOG4105WKT Replication Protein E3S63_10050 ENOG4105WKT Replication Protein E3S63_10055 ENOG4108BUD transposase E3S63_10075 ENOG4105CGH 5'-nucleotidase E3S63_10080 ENOG4105Q2H domain protein E3S63_10115 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E3S63_10120 ENOG4105CDU Replicative dna helicase E3S63_10130 ENOG4105BZR domain protein E3S63_10140 ENOG4105DWV Homoserine O-trans-acetylase E3S63_10165 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E3S63_10170 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S63_10175 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E3S63_10185 ENOG410848D S4 domain protein YaaA E3S63_10190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E3S63_10225 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E3S63_10245 ENOG4105VEQ Cold shock protein E3S63_10260 ENOG4105C19 ABC transporter E3S63_10275 ENOG4105D9G High-affinity E3S63_10285 ENOG4105FR1 rard protein E3S63_10290 ENOG4107QPK )-transporter E3S63_10370 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E3S63_10375 ENOG4105CIH Imidazole acetol-phosphate transaminase E3S63_10385 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E3S63_10400 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E3S63_10410 ENOG4105J1V Triacylglycerol lipase E3S63_10430 ENOG4107QJZ Glycosyl transferase, family 2 E3S63_10440 ENOG4105HTX biosynthesis protein E3S63_10460 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) E3S63_10465 ENOG4107XC4 flavin reductase domain protein, FMN-binding E3S63_10485 ENOG4105EW6 flavin reductase domain protein, FMN-binding E3S63_10500 ENOG4108XJK accessory Sec system protein Asp1 E3S63_10505 ENOG41089G2 accessory Sec system protein Asp2 E3S63_10510 ENOG4106E62 Accessory Sec system protein Asp3 E3S63_10535 ENOG4105WQI isochorismatase E3S63_10540 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase E3S63_10550 ENOG4105DG6 mannose-6-phosphate isomerase E3S63_10555 ENOG4105DM4 PTS System E3S63_10595 ENOG4105DBV ornithine carbamoyltransferase E3S63_10605 ENOG4105C5B carbamate kinase E3S63_10625 ENOG4108U05 Transcriptional regulator E3S63_10635 ENOG4105G6Z alkaline phosphatase E3S63_10685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E3S63_10690 ENOG4108Z73 Siroheme synthase E3S63_10700 ENOG4105D4T Citrate transporter E3S63_10705 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase E3S63_10710 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) E3S63_10725 ENOG4105C94 Transporter E3S63_10730 ENOG4105TRT Transcriptional regulator E3S63_10760 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E3S63_10770 ENOG4105DWT malate dehydrogenase (quinone) E3S63_10785 ENOG4108JPW Aminotransferase E3S63_10790 ENOG4105CUB amino acid E3S63_10800 ENOG4107FQX Alpha-acetolactate decarboxylase E3S63_10805 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3S63_10865 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) E3S63_10890 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase E3S63_10940 ENOG4105VPS UPF0291 protein E3S63_10975 ENOG4105EXC Acyl-transferase E3S63_10980 ENOG41068JE domain protein E3S63_11035 ENOG4108UW5 maltose o-acetyltransferase E3S63_11055 ENOG4105EYF MMPL domain protein E3S63_11080 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E3S63_11085 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase E3S63_11095 ENOG41068JE domain protein E3S63_11105 ENOG4105CMU LysR family (Transcriptional regulator E3S63_11115 ENOG41067MG lrgb family E3S63_11145 ENOG4108UZ3 Transporter E3S63_11165 ENOG4105EJQ L-serine dehydratase E3S63_11180 ENOG4108Z7F N-acetyltransferase E3S63_11185 ENOG4108Z6X (sortase) family E3S63_11190 ENOG4106KKU E3S63_11195 ENOG4108Z15 abc transporter atp-binding protein E3S63_11200 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) E3S63_11205 ENOG4105C5I Dehydrogenase E3S63_11215 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase E3S63_11225 ENOG41090MY MarR family Transcriptional regulator E3S63_11235 ENOG4105FBA Phospholipase Carboxylesterase E3S63_11255 ENOG4105CJ1 ABC, transporter E3S63_11265 ENOG4107T5V SNARE associated Golgi E3S63_11270 ENOG4105DJB Major Facilitator Superfamily E3S63_11280 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) E3S63_11295 ENOG4105G3Z GntR family transcriptional regulator E3S63_11300 ENOG4105CMG Carbohydrate kinase E3S63_11375 ENOG4105M6F mutator MutT protein E3S63_11465 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) E3S63_11470 ENOG4105CFC Transporter E3S63_11475 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E3S63_11480 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein E3S63_11535 ENOG4105CBC glutamate synthase E3S63_11540 ENOG4105PQ4 (LipO)protein E3S63_11555 ENOG4105CN9 Peptidase m42 family protein E3S63_11560 ENOG41083J0 (ABC) transporter E3S63_11565 ENOG4105C4B ABC transporter, permease E3S63_11570 ENOG4105F27 Major Facilitator E3S63_11575 ENOG4105EBR Carboxylesterase E3S63_11580 ENOG4107QTZ amino acid E3S63_11585 ENOG4105CZ9 Domain of unknown function (DU1801) E3S63_11605 ENOG4105E90 ABC transporter E3S63_11615 ENOG4105R40 Glycine betaine carnitine choline E3S63_11620 ENOG4105C57 major facilitator superfamily E3S63_11625 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) E3S63_11640 ENOG4105C0X amino acid E3S63_11645 ENOG4105EEQ Na H antiporter E3S63_11650 ENOG4105C85 amino acid E3S63_11670 ENOG4105C2C drug resistance transporter, Bcr CflA E3S63_11680 ENOG4105BZW Glycerate kinase E3S63_11700 ENOG4105BZ1 (ABC) transporter E3S63_11710 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) E3S63_11715 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E3S63_11725 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E3S63_11785 ENOG4105EAB amino acid AbC transporter E3S63_11790 ENOG4105DRP amino acid AbC transporter E3S63_11795 ENOG4105CDA abc transporter atp-binding protein E3S63_11835 ENOG4105DSE periplasmic solute binding protein E3S63_11850 ENOG4105TMB Formate nitrite transporter E3S63_11855 ENOG4108XSB acetyltransferase, (GNAT) family E3S63_11865 ENOG4108IFG nitrite reductase, (NAD(P)H) E3S63_11870 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit E3S63_11875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E3S63_11885 ENOG4108IUE nitrate reductase beta subunit E3S63_11915 ENOG4107TXC Transcriptional regulator E3S63_11955 ENOG410606W general stress protein E3S63_11985 ENOG4105ECB domain protein E3S63_12035 ENOG4105DWT malate dehydrogenase (quinone) E3S63_12100 ENOG4105CW7 secretion protein, HlyD family E3S63_12105 ENOG4105C0R drug resistance transporter emrb qaca subfamily E3S63_12130 ENOG4105D7N magnesium and cobalt transport protein CorA E3S63_12140 ENOG4105D6U Sodium Glutamate Symporter E3S63_12150 ENOG4105KAF membrAne E3S63_12155 ENOG4108IUX (ABC) transporter E3S63_12160 ENOG4105RHA ABC transporter, permease E3S63_12180 ENOG4108RPX mosc domain containing protein E3S63_12185 ENOG4105E66 phosphoriboisomerase A E3S63_12205 ENOG4105C5Q Transcriptional regulator E3S63_12220 ENOG4105CH2 amidohydrolase E3S63_12225 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E3S63_12245 ENOG4108Q3X Transcriptional regulator E3S63_12250 ENOG4105CI1 PTS System E3S63_12260 ENOG4105C09 Bile acid E3S63_12265 ENOG4107YBY Hydrolase E3S63_12335 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis E3S63_12365 ENOG4105DFD Na H antiporter E3S63_12375 ENOG41068JE domain protein E3S63_12440 ENOG4105FDT acyl-CoA dehydrogenase E3S63_12455 ENOG4107ZYJ bioY protein E3S63_12470 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E3S63_12475 ENOG4105E0C molybdate abc transporter E3S63_12480 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) E3S63_12485 ENOG4105D06 uba thif-type nad fad binding protein E3S63_12490 ENOG4105EPU Molybdenum cofactor synthesis domain protein E3S63_12500 ENOG4105CVM Molybdenum cofactor synthesis domain protein E3S63_12505 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein E3S63_12510 ENOG4108ZAF Molybdopterin E3S63_12545 ENOG41065XD Transcriptional regulator E3S63_12560 ENOG4108TV1 Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) E3S63_12590 ENOG4105CSC Glucose uptake protein E3S63_12610 ENOG4105C7N Xanthine uracil vitamin C permease E3S63_12725 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E3S63_12730 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) E3S63_12820 ENOG4107RRE RNA-directed DNA polymerase E3S63_12835 ENOG4107FQX Alpha-acetolactate decarboxylase E3S63_12855 ENOG4106AM8 polysaccharide lyase family 8 E3S63_12865 ENOG4105VUF Transcriptional regulator E3S63_12885 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E3S63_12890 ENOG4105E98 transcriptional regulator DeoR family E3S63_12915 ENOG4105VCP PTS System E3S63_12920 ENOG4105CK1 PTS System E3S63_12935 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E3S63_12940 ENOG4105CIS alcohol dehydrogenase E3S63_12945 ENOG4105C94 Transporter E3S63_12960 ENOG4105VBF alkaline shock protein E3S63_12970 ENOG4107SFI Major Facilitator superfamily E3S63_12980 ENOG4106M28 alanine racemase domain protein E3S63_12990 ENOG4108HUF Transporter E3S63_12995 ENOG4105DQ5 transport system permease protein E3S63_13000 ENOG4108U1V ABC transporter, permease E3S63_13005 ENOG4105DWD nucleoside recognition domain protein E3S63_13015 ENOG4107K5X Membrane-bound metal-dependent hydrolase E3S63_13025 ENOG4108UT2 hemolysin iii E3S63_13045 ENOG4105D1F ATP-binding protein E3S63_13105 ENOG4105CYW agmatinase E3S63_13110 ENOG4105C8B TIGR00159 family E3S63_13135 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein E3S63_13140 ENOG4105ETD TRANSCRIPTIONal E3S63_13150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E3S63_13155 ENOG4105DKW ABC transporter E3S63_13180 ENOG4105PGM cation diffusion facilitator family transporter E3S63_13195 ENOG4105DG6 mannose-6-phosphate isomerase E3S63_13215 ENOG4108RMU ferritin dps family protein E3S63_13220 ENOG4105D3A purine nucleoside phosphorylase DeoD-type E3S63_13225 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) E3S63_13285 ENOG4105D2N Aldolase E3S63_13290 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) E3S63_13305 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E3S63_13315 ENOG4107104 thymidine kinase E3S63_13325 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E3S63_13330 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) E3S63_13335 ENOG4107WAU Protein tyrosine phosphatase E3S63_13355 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E3S63_13445 ENOG4105DWF phosphomethylpyrimidine kinase E3S63_13485 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) E3S63_13490 ENOG4105VPX protein, conserved in bacteria E3S63_13515 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) E3S63_13550 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E3S63_13565 ENOG4105CKV Membrane E3S63_13580 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E3S63_13595 ENOG4107SGM protein serine threonine phosphatase E3S63_13600 ENOG4105WN5 stage II sporulation protein E3S63_13665 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E3S63_13685 ENOG4105C7K acetolactate synthase E3S63_13700 ENOG4105K8N protein family UPF0079, ATPase E3S63_13705 ENOG41072GX Peptidase M22 Glycoprotease E3S63_13710 ENOG410801F ribosomal-protein-alanine acetyltransferase E3S63_13720 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) E3S63_13730 ENOG4105C5H ABC transporter E3S63_13740 ENOG4105CUC YeeE YedE family protein E3S63_13750 ENOG4105BZU Histidine kinase E3S63_13830 ENOG4105CZN Potassium uptake protein E3S63_13885 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)